calcium channel blockers

Summary

Summary: A class of drugs that act by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. Since they are inducers of vascular and other smooth muscle relaxation, they are used in the drug therapy of hypertension and cerebrovascular spasms, as myocardial protective agents, and in the relaxation of uterine spasms.

Top Publications

  1. ncbi The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report
    Aram V Chobanian
    Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    JAMA 289:2560-72. 2003
  2. ncbi International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels
    William A Catterall
    Department of Pharmacology, University of Washington, Mailstop 357280, Seattle, WA 98195 7280, USA
    Pharmacol Rev 57:411-25. 2005
  3. ncbi Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    E J Lewis
    Department of Medicine, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL 60612, USA
    N Engl J Med 345:851-60. 2001
  4. ncbi Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in Ca(v)2.1 knockin migraine mice
    Angelita Tottene
    Department of Biomedical Sciences, University of Padova and CNR Institute of Neuroscience, Viale G Colombo 3, Padua, Italy
    Neuron 61:762-73. 2009
  5. ncbi Benidipine reduces albuminuria and plasma aldosterone in mild-to-moderate stage chronic kidney disease with albuminuria
    Masanori Abe
    Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Hypertens Res 34:268-73. 2011
  6. ncbi Reversal of experimental neuropathic pain by T-type calcium channel blockers
    Ahmet Dogrul
    Department of Pharmacology, Faculty of Medicine, Gulhane Medical Military Academy, Ankara, Turkey
    Pain 105:159-68. 2003
  7. pmc K+ channels as targets for specific immunomodulation
    K George Chandy
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    Trends Pharmacol Sci 25:280-9. 2004
  8. ncbi Effects of beta blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    Lancet Neurol 9:469-80. 2010
  9. ncbi Differential effects between a calcium channel blocker and a diuretic when used in combination with angiotensin II receptor blocker on central aortic pressure in hypertensive patients
    Yoshio Matsui
    Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, 3311 1 Yakushiji, Shimotsuke, Tochigi, Japan
    Hypertension 54:716-23. 2009
  10. ncbi 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release
    Martin D Bootman
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    FASEB J 16:1145-50. 2002

Detail Information

Publications371 found, 100 shown here

  1. ncbi The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report
    Aram V Chobanian
    Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    JAMA 289:2560-72. 2003
    ..drug classes (angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, beta-blockers, calcium channel blockers); (5) Most patients with hypertension will require 2 or more antihypertensive medications to achieve goal ..
  2. ncbi International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels
    William A Catterall
    Department of Pharmacology, University of Washington, Mailstop 357280, Seattle, WA 98195 7280, USA
    Pharmacol Rev 57:411-25. 2005
    ..This article presents the molecular relationships and physiological functions of these calcium channel proteins and provides comprehensive information on their molecular, genetic, physiological, and pharmacological properties...
  3. ncbi Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    E J Lewis
    Department of Medicine, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL 60612, USA
    N Engl J Med 345:851-60. 2001
    ..CONCLUSIONS: The angiotensin-II-receptor blocker irbesartan is effective in protecting against the progression of nephropathy due to type 2 diabetes. This protection is independent of the reduction in blood pressure it causes...
  4. ncbi Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in Ca(v)2.1 knockin migraine mice
    Angelita Tottene
    Department of Biomedical Sciences, University of Padova and CNR Institute of Neuroscience, Viale G Colombo 3, Padua, Italy
    Neuron 61:762-73. 2009
    ..The synapse-specific effect of FHM1 mutations points to disruption of excitation-inhibition balance and neuronal hyperactivity as the basis for episodic vulnerability to CSD ignition in migraine...
  5. ncbi Benidipine reduces albuminuria and plasma aldosterone in mild-to-moderate stage chronic kidney disease with albuminuria
    Masanori Abe
    Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Hypertens Res 34:268-73. 2011
    ..It may be concluded that benidipine results in a greater reduction of plasma aldosterone and albuminuria than amlodipine, and that these effects are independent of BP reduction...
  6. ncbi Reversal of experimental neuropathic pain by T-type calcium channel blockers
    Ahmet Dogrul
    Department of Pharmacology, Faculty of Medicine, Gulhane Medical Military Academy, Ankara, Turkey
    Pain 105:159-68. 2003
    ..The data support the view that selective T-type calcium channel blockers may have significant potential in the treatment of neuropathic pain states.
  7. pmc K+ channels as targets for specific immunomodulation
    K George Chandy
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    Trends Pharmacol Sci 25:280-9. 2004
    ..3 and IKCa1 channels, and provide a rationale for the potential therapeutic use of these inhibitors in immunological disorders...
  8. ncbi Effects of beta blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    Lancet Neurol 9:469-80. 2010
    ..We aimed to investigate whether the effects of these drugs on variability in blood pressure might explain these disparities in effect on stroke risk...
  9. ncbi Differential effects between a calcium channel blocker and a diuretic when used in combination with angiotensin II receptor blocker on central aortic pressure in hypertensive patients
    Yoshio Matsui
    Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, 3311 1 Yakushiji, Shimotsuke, Tochigi, Japan
    Hypertension 54:716-23. 2009
    The aim of this study was to compare the effects between calcium channel blockers and diuretics when used in combination with angiotensin II receptor blocker on aortic systolic blood pressure (BP) and brachial ambulatory systolic BP...
  10. ncbi 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release
    Martin D Bootman
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    FASEB J 16:1145-50. 2002
    ..These data indicate that although it must be used with caution, 2-APB can be useful in probing certain aspects of Ca2+ signaling...
  11. ncbi Antiproteinuric effect of the calcium channel blocker cilnidipine added to renin-angiotensin inhibition in hypertensive patients with chronic renal disease
    T Fujita
    Department of Nephrology and Endocrinology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Kidney Int 72:1543-9. 2007
    ..This study suggests that cilnidipine is superior to amlodipine in preventing the progression of proteinuria in hypertensive patients when coupled with a renin-angiotensin system inhibitor...
  12. ncbi Memory reconsolidation and extinction have distinct temporal and biochemical signatures
    Akinobu Suzuki
    Department of Agricultural Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo 156 8502, Japan
    J Neurosci 24:4787-95. 2004
    ..These studies demonstrate the dynamic nature of memory processing after retrieval and represent a first step toward a molecular dissection of underlying mechanisms...
  13. ncbi Combination therapy versus monotherapy in reducing blood pressure: meta-analysis on 11,000 participants from 42 trials
    David S Wald
    Wolfson Institute of Preventive Medicine at Barts and The London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, United Kingdom
    Am J Med 122:290-300. 2009
    ..blood pressure-lowering drugs from any 2 classes of thiazides, beta-blockers, angiotensin-converting enzyme inhibitors, and calcium channel blockers over 1 drug alone and to compare the effects of combining drugs with doubling dose.
  14. ncbi Visual function and perfusion of the optic nerve head after application of centrally acting calcium-channel blockers
    Andreas G Boehm
    Department of OphthalmologyUniversity of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Graefes Arch Clin Exp Ophthalmol 241:34-8. 2003
    ..To understand the mechanism of action of nimodipine on the visual system, the aim of this study was to examine the influence of nimodipine on different hemodynamic parameters and contrast sensitivity in healthy subjects...
  15. ncbi Renal and vascular protective effects of cilnidipine in patients with essential hypertension
    Satoshi Morimoto
    Department of Internal Medicine, Ohmihachiman City Hospital, Japan
    J Hypertens 25:2178-83. 2007
    Cilnidipine is a calcium channel blocker that blocks both L and N-type calcium channels. L/N-type calcium channel blockers exhibit sympatholytic action and a renal protective effect via dilation of afferent and efferent arterioles of the ..
  16. ncbi Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials
    Fiona Turnbull
    Blood Pressure Lowering Treatment Trialists Collaboration, The George Institute for International Health, University of Sydney, PO Box 576, Newtown, Sydney, New South Wales 2042, Australia
    Lancet 362:1527-35. 2003
    ....
  17. ncbi Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines
    W Xu
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 21:5944-51. 2001
    ..Our results suggest that functional and pharmacological criteria used commonly to distinguish among different Ca currents greatly underestimate the biological importance of L-type channels in cells expressing Ca(v)1.3alpha(1)...
  18. pmc Comparative effect of angiotensin II type I receptor blockers and calcium channel blockers on laboratory parameters in hypertensive patients with type 2 diabetes
    Yayoi Nishida
    Division of Genomic Epidemiology and Clinical Trials, Advanced MedicalResearch Center, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo 173 8610, Japan
    Cardiovasc Diabetol 11:53. 2012
    Both angiotensin II type I receptor blockers (ARBs) and calcium channel blockers (CCBs) are widely used antihypertensive drugs...
  19. pmc L-type calcium channel blockers exert an antiinflammatory effect by suppressing expression of plasminogen receptors on macrophages
    Riku Das
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave NB50, Cleveland, OH 44195, USA
    Circ Res 105:167-75. 2009
    ..These findings demonstrate that Plg-R expression on macrophages is dependent on Ca(v)1.2 LTCC subunit expression. Suppression of Plg-Rs may contribute to the antiinflammatory effects of the widely used LTCC blockers...
  20. pmc Combined therapy with renin-angiotensin system and calcium channel blockers in type 2 diabetic hypertensive patients with proteinuria: effects on soluble TWEAK, PTX3, and flow-mediated dilation
    Mahmut Ilker Yilmaz
    Department of Nephrology, Gulhane School of Medicine, Ankara, Turkey
    Clin J Am Soc Nephrol 5:1174-81. 2010
    ....
  21. pmc L-type calcium channel blockers and Parkinson disease in Denmark
    Beate Ritz
    Department of Epidemiology, University of California at Los Angeles School of Public Health, Los Angeles, CA, USA
    Ann Neurol 67:600-6. 2010
    This study was undertaken to investigate L-type calcium channel blockers of the dihydropyridine class for association with Parkinson disease (PD), because some of these drugs traverse the blood-brain barrier, are potentially ..
  22. ncbi Structure-function relationships of omega-conotoxin GVIA. Synthesis, structure, calcium channel binding, and functional assay of alanine-substituted analogues
    M J Lew
    Department of Pharmacology, University of Melbourne, Parkville 3052, Victoria, Australia
    J Biol Chem 272:12014-23. 1997
    ....
  23. pmc Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I(T)window
    Fanny M Dreyfus
    Université Pierre et Marie Curie Paris, 6, Paris F 75005, France
    J Neurosci 30:99-109. 2010
    ....
  24. ncbi Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker
    Slobodan M Todorovic
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Brain Res 951:336-40. 2002
    ..This suggests that peripherally acting T-type Ca(2+) channel blockers can be useful antinociceptive agents...
  25. ncbi Meta-analysis: effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal disease
    Regina Kunz
    Basel Institute for Clinical Epidemiology and Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Ann Intern Med 148:30-48. 2008
    ..Reports suggest that angiotensin-receptor blockers (ARBs) reduce proteinuria, but results are variable. The relative effect of ARBs and angiotensin-converting enzyme (ACE) inhibitors, and their combined administration, remains uncertain...
  26. ncbi Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients
    Kenneth Jamerson
    Division of Cardiovascular Medicine, University of Michigan Health System, 24 Frank Lloyd Wright Dr, Lobby M, Ann Arbor, MI 48106, USA
    N Engl J Med 359:2417-28. 2008
    ....
  27. ncbi Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-B
    Bjorn Dahlof
    Department of Medicine, Sahlgrenska University Hospital Ostra, SE 416 85 Goteborg, Sweden
    Lancet 366:895-906. 2005
    ..Our aim, therefore, was to compare the effect on non-fatal myocardial infarction and fatal CHD of combinations of atenolol with a thiazide versus amlodipine with perindopril...
  28. ncbi Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial
    George L Bakris
    Hypertensive Diseases Unit, Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Lancet 375:1173-81. 2010
    ..We assessed the effects of these drug combinations on progression of chronic kidney disease...
  29. ncbi Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial
    Peter S Staats
    Division of Pain Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    JAMA 291:63-70. 2004
    ..Ziconotide (formerly SNX-111) selectively blocks N-type voltage-sensitive calcium channels and may be effective in patients with pain that is refractory to opioid therapy or those with intolerable opioid-related adverse effects...
  30. ncbi N-type Ca2+ channels carry the largest current: implications for nanodomains and transmitter release
    Alexander M Weber
    Laboratory of Synaptic Transmission, Toronto Western Research Institute, Toronto, Ontario, Canada
    Nat Neurosci 13:1348-50. 2010
    ..Mathematical modeling predicts that the Ca(V)2.2 Ca(2+) nanodomain, which is ∼25% more extensive than that generated by Ca(V)1, can activate a calcium-fusion sensor located on the proximal face of the synaptic vesicle...
  31. ncbi CaV1.3 channels are essential for development and presynaptic activity of cochlear inner hair cells
    Andreas Brandt
    Department of Otolaryngology, Goettingen University Medical School, 37075 Goettingen, Germany
    J Neurosci 23:10832-40. 2003
    ..We conclude that CaV1.3 channels are essential for normal hair cell development and synaptic transmission...
  32. ncbi Expression of N-type calcium channels in human adrenocortical cells and their contribution to corticosteroid synthesis
    Shizuka Aritomi
    Research Center, Ajinomoto Pharmaceuticals, Kanagawa, Japan
    Hypertens Res 34:193-201. 2011
    ..We also investigated the inhibitory activities of some types of dihydropyridine calcium channel blockers (CCBs; cilnidipine: L-/N-type CCB, efonidipine: L-/T-type CCB, and nifedipine: L-type CCB), and these ..
  33. pmc Rem, a member of the RGK GTPases, inhibits recombinant CaV1.2 channels using multiple mechanisms that require distinct conformations of the GTPase
    Tingting Yang
    Department of Physiology and Cellular Biophysics, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    J Physiol 588:1665-81. 2010
    ....
  34. pmc Atrial cellular electrophysiological changes in patients with ventricular dysfunction may predispose to AF
    Antony J Workman
    British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, UK
    Heart Rhythm 6:445-51. 2009
    ..Left ventricular systolic dysfunction (LVSD) is a risk factor for atrial fibrillation (AF), but the atrial cellular electrophysiological mechanisms in humans are unclear...
  35. ncbi Long-term depression of synaptic transmission in the adult mouse insular cortex in vitro
    Ming Gang Liu
    Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Eur J Neurosci 38:3128-45. 2013
    ..Our studies have characterised the basic mechanisms of LTD in the IC at the network level, and suggest that two different forms of LTD may co-exist in the same population of IC synapses. ..
  36. ncbi omega-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn
    Leonid Motin
    Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia
    Neuropharmacology 55:860-4. 2008
    ....
  37. ncbi Peripheral edema associated with calcium channel blockers: incidence and withdrawal rate--a meta-analysis of randomized trials
    Harikrishna Makani
    Division of Cardiology, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    J Hypertens 29:1270-80. 2011
    Peripheral edema is considered to be a common and annoying adverse effect of calcium channel blockers (CCBs). It has been thought to occur secondary to arteriolar dilatation causing intracapillary hypertension and fluid extravasation...
  38. pmc CRACM/Orai ion channel expression and function in human lung mast cells
    Ian Ashmole
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 129:1628-35.e2. 2012
    ..However, the identity of the ion channels underlying this Ca(2+) influx is unknown. The recently discovered members of the CRACM/Orai ion channel family that carries the Ca(2+) release-activated Ca(2+) current are candidates...
  39. pmc Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrier
    Daniel Paris
    The Roskamp Institute, Sarasota, Florida 34243, United States of America
    Mol Med 17:149-62. 2011
    ..large population-based or clinical trial studies have suggested that certain dihydropyridine (DHP) L-type calcium channel blockers (CCBs) used for the treatment of hypertension may confer protection against the development of Alzheimer ..
  40. pmc Long-acting dihydropyridine calcium-channel blockers and sympathetic nervous system activity in hypertension: a literature review comparing amlodipine and nifedipine GITS
    Corey B Toal
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Blood Press 21:3-10. 2012
    ..There are small differences between the drugs in the extent to which each activates the sympathetic nervous system with an overall non-significant trend in favour of nifedipine GITS...
  41. ncbi Comparison between cilnidipine and amlodipine besilate with respect to proteinuria in hypertensive patients with renal diseases
    Shunichi Kojima
    Division of Internal Medicine, National Hospital Organization Shizuoka Medical Center, Japan
    Hypertens Res 27:379-85. 2004
    Unlike other dihydropyridine calcium channel blockers (CCBs), cilnidipine has been reported to exert an N-type calcium-channel-blocking activity and to reduce sympathetic hyperactivity...
  42. ncbi Effects of candesartan compared with amlodipine in hypertensive patients with high cardiovascular risks: candesartan antihypertensive survival evaluation in Japan trial
    Toshio Ogihara
    Osaka University Graduate School of Medicine, Osaka, Japan
    Hypertension 51:393-8. 2008
    ..We disclosed that candesartan-based and amlodipine-based regimens produced no statistical differences in terms of the primary cardiovascular end point, whereas candesartan prevented new-onset diabetes more effectively than amlodipine...
  43. ncbi Combination therapy in hypertension
    Alan H Gradman
    The Western Pennsylvania Hospital, Pittsburgh, Pennsylvania and Temple University School of Medicine, Philadelphia, PA 15224, USA
    J Am Soc Hypertens 4:42-50. 2010
    ..The advantages and disadvantages of single pill (fixed) drug combinations, and the implications of recent clinical trials involving specific combination strategies will also be discussed...
  44. ncbi The Felodipine Event Reduction (FEVER) Study: a randomized long-term placebo-controlled trial in Chinese hypertensive patients
    Lisheng Liu
    Division of Hypertension, Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, Beijing, China
    J Hypertens 23:2157-72. 2005
    ....
  45. ncbi Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels
    G Berecki
    Department of Physiology and Pharmacology, University of Calgary, Alberta, T2N4N1 Canada
    Mol Pharmacol 77:139-48. 2010
    ..These N-type Ca(2+) channel-selective omega-conotoxins are therefore useful as neurophysiological tools and as potential therapeutic agents to inhibit nociceptive pain pathways...
  46. ncbi Voltage-dependent calcium channels
    L Lacinova
    Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlarska 5, 833 34 Bratislava 37, Slovakia
    Gen Physiol Biophys 24:1-78. 2005
    ..Transfer of 30 % of charge correlates with activation of 70 % of measurable macroscopic current. Prolonged depolarization does not immobilize charge movement of the Ca(v)3.1 channel...
  47. pmc Nanomolar potency and selectivity of a Ca²⁺ release-activated Ca²⁺ channel inhibitor against store-operated Ca²⁺ entry and migration of vascular smooth muscle cells
    Jing Li
    Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Br J Pharmacol 164:382-93. 2011
    ..The aim was to advance the understanding of Orai proteins and identify a specific inhibitor of the associated calcium entry mechanism in vascular smooth muscle cells (VSMCs)...
  48. pmc Functional, morphological and molecular characterization of bladder dysfunction in streptozotocin-induced diabetic mice: evidence of a role for L-type voltage-operated Ca2+ channels
    L O S Leiria
    Department of Pharmacology, Faculty of Medical Sciences, University of Campinas UNICAMP, Campinas, SP, Brazil
    Br J Pharmacol 163:1276-88. 2011
    ....
  49. pmc Long-term efficacy of a combination of amlodipine and olmesartan medoxomil ± hydrochlorothiazide in patients with hypertension stratified by age, race and diabetes status: a substudy of the COACH trial
    S Oparil
    Division of Cardiovascular Diseases, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294 0007, USA
    J Hum Hypertens 24:831-8. 2010
    ..3% of Blacks, 67.8% of non-Blacks, 26.9% of patients with diabetes and 72.9% of patients without diabetes. The combination of AML + OM ± HCTZ was efficacious, safe and well tolerated by these subgroups...
  50. ncbi A titrate-to-goal study of switching patients uncontrolled on antihypertensive monotherapy to fixed-dose combinations of amlodipine and olmesartan medoxomil ± hydrochlorothiazide
    Matthew R Weir
    University of Maryland School of Medicine, Baltimore, MD, USA
    J Clin Hypertens (Greenwich) 13:404-12. 2011
    ....
  51. ncbi The roles of T-type calcium channel in the development of neuropathic pain following chronic compression of rat dorsal root ganglia
    Xian jie Wen
    Department of Anesthesiology, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou, China
    Pharmacology 85:295-300. 2010
    ..05). These data support the view that spinal T-type calcium (Cav3.2 and Cav3.3 but not Cav3.1) channels may play an important role in the pathogenesis of neuropathic pain...
  52. ncbi Hydrogen sulphide is an inhibitor of L-type calcium channels and mechanical contraction in rat cardiomyocytes
    Ying Gang Sun
    Key Laboratory of Molecular Medicine, The Ministry of Education, Department of Physiology and Pathophysiology, Fudan University Shanghai Medical College, 138 Yi Xue Yuan Road, Shanghai 200032, P R China
    Cardiovasc Res 79:632-41. 2008
    ..The present study aims to examine the hypothesis that H(2)S is a novel inhibitor of the L-type calcium channel current (I(Ca,L))...
  53. ncbi Amlodipine increases endothelial nitric oxide release by modulating binding of native eNOS protein complex to caveolin-1
    Arpeeta Sharma
    Providence Heart Lung Institute at St Paul s Hospital, The James Hogg Research Centre, University of British Columbia, Canada
    Eur J Pharmacol 659:206-12. 2011
    Amongst calcium channel blockers, amlodipine is known to have unique cardioprotective activities likely attributable to its capacity to increase nitric oxide (NO) release from endothelial cells (EC)...
  54. ncbi Verapamil inhibits L-type calcium channel mediated apoptosis in human colon cancer cells
    Antoni Zawadzki
    Department of Surgery, Malmo University Hospital, Lund University, Malmo, Sweden
    Dis Colon Rectum 51:1696-702. 2008
    Treatment with calcium channel blockers have been associated with increased colon cancer mortality in epidemiologic studies. We examined the potential expression and function of calcium channels in two human colon cancer cell lines.
  55. ncbi Small-molecule inhibitors of store-operated calcium entry
    Zachary K Sweeney
    Department of Medicinal Chemistry, Genentech, Inc 1 DNA Way, South San Francisco, CA 94080, USA
    ChemMedChem 4:706-18. 2009
    ..Where possible, methods that were used to characterize the mechanism of action of the inhibitors are also described...
  56. ncbi Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial
    Henry R Black
    Rush Medical College of Rush University, Chicago, IL 60612, USA
    JAMA 289:2073-82. 2003
    ..Hypertensive patients are often given a calcium antagonist to reduce cardiovascular disease risk, but the benefit compared with other drug classes is controversial...
  57. pmc Do calcium channel blockers rescue dying photoreceptors in the Pde6b ( rd1 ) mouse?
    Peter Barabas
    Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Adv Exp Med Biol 664:491-9. 2010
    ..We also discuss potential involvement of recently identified Ca(2+)-dependent mechanisms that include protective calcium ATPase mechanisms, ryanodine and IP3 calcium stores, and store operated channels in Pde6b ( rd1 ) neurodegeneration...
  58. ncbi The influence of one-year treatment by angiotensin converting enzyme inhibitor on baroreflex sensitivity and flow-mediated vasodilation of the brachial artery in essential hypertension--comparison with calcium channel blockers
    Masanori Munakata
    Division of Hypertension and Cardiology, Tohoku Rosai Hospital, Sendai, Japan
    Clin Exp Hypertens 25:169-81. 2003
    ..Both baroreflex sensitivity and flow-mediated vasodilator function have been recognized to have prognostic significance in cardiovascular diseases. Long-term antihypertensive treatment effects on these parameters, however, remain unclear...
  59. pmc T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome
    Fabrice Marger
    Departement de Physiologie, Institut de Genomique Fonctionnelle, 34094 Montpellier, France
    Proc Natl Acad Sci U S A 108:11268-73. 2011
    ..2 as a promising target for the development of efficient analgesics for the visceral discomfort and pain associated with IBS...
  60. pmc TRPC1 and STIM1 mediate capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells
    Lih Chyuan Ng
    Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
    J Physiol 587:2429-42. 2009
    ..Taken together, store depletion causes activation of voltage-operated Ca(2+) entry and CCE. These data provide direct evidence that CCE is mediated by TRPC1 channel through activation of STIM1 in mouse PASMCs...
  61. ncbi Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease
    Antonio Di Sabatino
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    J Immunol 183:3454-62. 2009
    ....
  62. ncbi Ziconotide, an intrathecally administered N-type calcium channel antagonist for the treatment of chronic pain
    Daniel P Wermeling
    Department of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA
    Pharmacotherapy 25:1084-94. 2005
    ..A low initial infusion rate of 0.1 microg/hour and limiting infusion rate increases to 2-3 times/week are now recommended. Patients responsive to intrathecal ziconotide require an implanted infusion system to receive long-term therapy...
  63. pmc A caveolae-targeted L-type Ca²+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility
    Catherine A Makarewich
    Cardiovascular Research Center and Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Circ Res 110:669-74. 2012
    ..However, some LTCCs are housed in caveolin-3 (Cav-3)-enriched signaling microdomains and are not directly involved in contraction. The function of these LTCCs is unknown...
  64. ncbi A meta-analysis of the effects of treatment on left ventricular mass in essential hypertension
    Arnfried U Klingbeil
    Department of Medicine IV, University of Erlangen Nurnberg, Nuremberg, Germany
    Am J Med 115:41-6. 2003
    ..Antihypertensive medications have different effects on left ventricular mass. We conducted a meta-analysis of double-blind trials that measured the effects of antihypertensive therapy on left ventricular mass...
  65. ncbi Calcium channel blockers inhibit galvanotaxis in human keratinocytes
    Donna R Trollinger
    Section of Molecular and Cellular Biology, University of California, Davis 95616, USA
    J Cell Physiol 193:1-9. 2002
    ..These findings suggest that calcium influx through Ca(2+) channels is required for directed migration of keratinocytes during galvanotaxis and that directional migration and migration speed are probably controlled by separate mechanisms...
  66. ncbi Comparison between valsartan and valsartan plus cilnidipine in type II diabetics with normo- and microalbuminuria
    K Katayama
    First Department of Internal Medicine, Mie University, Mie, Japan
    Kidney Int 70:151-6. 2006
    ..391). There were also no significant differences in the side effects between the two groups. Cilnidipine was thus found to show an additive effect with valsartan and thereby caused a reduction in albuminuria in type II diabetics...
  67. ncbi L-type calcium channels
    David J Triggle
    School of Pharmacy and Pharmaceutical Sciences, 126 Cooke Hall, State University of New York, Buffalo NY 14260 1200, USA
    Curr Pharm Des 12:443-57. 2006
    ..Limitations to these approaches are discussed...
  68. ncbi Loss of Cav1.3 channels reveals the critical role of L-type and BK channel coupling in pacemaking mouse adrenal chromaffin cells
    Andrea Marcantoni
    Department of Neuroscience, Nanostructured Interfaces and Surfaces Centre of Excellence, Consorzio Nazionale Interuniversitario per le Scienze Fisiche della Materia, 10125 Torino, Italy
    J Neurosci 30:491-504. 2010
    ..2, as subthreshold pacemaker channels in MCCs and open new interesting features about their role in the control of firing and catecholamine secretion at rest and during sustained stimulations matching acute stress...
  69. ncbi Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396
    Ming Li
    Department of Pharmacology SL 83, Tulane University Health Science Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Cardiovasc Drug Rev 23:173-96. 2005
    ..We conclude that NNC 55-0396, by virtue of its modified structure, does not produce the metabolite that causes inhibition of L-type Ca2+ channel channels, thus rendering it more selective to T-type Ca2+ channels...
  70. ncbi Adherence and persistence of single-pill ARB/CCB combination therapy compared to multiple-pill ARB/CCB regimens
    F Zeng
    MedImpact Healthcare Systems, Inc, San Diego, CA, USA
    Curr Med Res Opin 26:2877-87. 2010
    To evaluate the impact of angiotensin receptor blocker (ARBs)/dihydropyridine calcium channel blockers (CCBs) single-pill combination (SPC) on adherence to antihypertensive treatment in comparison to free combination of ARBs and CCBs.
  71. ncbi Omega-conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels
    Leonid Motin
    School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    Eur J Neurosci 25:435-44. 2007
    ..Omega-conotoxins CVIB and CVID may be useful as antagonists of N- and P/Q-type VGCCs, particularly in sensory neurons involved in processing primary nociceptive information...
  72. ncbi Antisympathetic and hemodynamic property of a dual L/N-type Ca(2+) channel blocker cilnidipine in rats
    Akira Takahara
    Pharmaceutical Research Laboratories, Ajinomoto Co, Inc, 1 1 Suzuki cho, Kawasaki ku, Kawasaki 210 8681, Japan
    Eur J Pharmacol 434:43-7. 2002
    ..The antisympathetic activity of cilnidipine is not excessive for an antihypertensive drug in comparison with that of omega-conotoxin MVIIA...
  73. pmc The skeletal L-type Ca(2+) current is a major contributor to excitation-coupled Ca(2+) entry
    Roger A Bannister
    Department of Physiology and Biophysics, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    J Gen Physiol 133:79-91. 2009
    ..Collectively, these results indicate that the skeletal muscle L-type channel is a major contributor to the Ca(2+) entry attributed to ECCE...
  74. ncbi Age-related working memory impairment is correlated with increases in the L-type calcium channel protein alpha1D (Cav1.3) in area CA1 of the hippocampus and both are ameliorated by chronic nimodipine treatment
    Lone M Veng
    Neuroscience Training Program, University of Colorado Health Sciences Center, Denver, CO, USA
    Brain Res Mol Brain Res 110:193-202. 2003
    ..These findings may have implications for patients with Alzheimer's disease, who show increased L-VSCC protein expression in the hippocampus, and for patients receiving chronic treatment with L-VSCC antagonists...
  75. ncbi A functional comparison of the venom of three Australian jellyfish--Chironex fleckeri, Chiropsalmus sp., and Carybdea xaymacana--on cytosolic Ca2+, haemolysis and Artemia sp. lethality
    Paul M Bailey
    Department of Biochemistry and Molecular Biology, School of Biomedical and Chemical Sciences, The University of Western Australia, Perth, WA 6009, Australia
    Toxicon 45:233-42. 2005
    ..This suggests that the observed lytic effects may not underlie the lethal effects of the venom, and raises the question of how such potent activities are dealt with by envenomed humans...
  76. ncbi Function and solution structure of Huwentoxin-X, a specific blocker of N-type calcium channels, from the Chinese bird spider Ornithoctonus huwena
    Zhonghua Liu
    College of Life Sciences, Peking University, Beijing 100087, China
    J Biol Chem 281:8628-35. 2006
    ..However, the dissimilarities of their binding surfaces provide some insights into their different selectivities for isoforms of N-type Ca2+ channels...
  77. ncbi Antinociceptive action of amlodipine blocking N-type Ca2+ channels at the primary afferent neurons in mice
    M Murakami
    Department of Molecular Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Eur J Pharmacol 419:175-81. 2001
    ..Furthermore, it is suggested that some N-type Ca2+ channel blockers might have therapeutic potential as analgesics when applied directly into the subarachnoidal space...
  78. pmc Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass
    Fredrick A Hilliard
    Division of Clinical Pharmacology, Oates Institute for Experimental Therapeutics, Vanderbilt University School of Medicine, Nashville, TN 37232 0575, USA
    J Mol Cell Cardiol 48:293-301. 2010
    ..Our results indicate that inhibition of the RyR2 open state provides a new therapeutic strategy to prevent diastolic Ca(2+) waves resulting in triggered arrhythmias, such as CPVT...
  79. ncbi The presence of cholinomimetic and calcium channel antagonist constituents in Piper betle Linn
    A H Gilani
    Department of Physiology and Pharmacology, The Aga Khan University Medical College, Karachi, Pakistan
    Phytother Res 14:436-42. 2000
    ..It is suggested that some of the traditional uses of this plant may be explained on the basis of these activities...
  80. ncbi Efficacy of various antihypertensive agents as evaluated by indices of vascular stiffness in elderly hypertensive patients
    Takeshi Takami
    Clinic Jinguumae, Kashihara, Japan
    Hypertens Res 26:609-14. 2003
    ....
  81. ncbi A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat
    Daniel A Clayton
    Medical Scientist Training Program, Neuroscience Program, and Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurosci 22:3628-37. 2002
    ..These data demonstrate the important role of NR2B in LTP and learning and memory and suggest a role for reduced NR2B expression in age-related cognitive decline...
  82. ncbi Peptides targeting voltage-gated calcium channels
    Raymond S Norton
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    Curr Pharm Des 14:2480-91. 2008
    ....
  83. pmc Recruitment of N-Type Ca(2+) channels during LTP enhances low release efficacy of hippocampal CA1 perforant path synapses
    Mohsin S Ahmed
    Department of Neuroscience, Columbia University, New York, NY 10032, USA
    Neuron 63:372-85. 2009
    ....
  84. ncbi Calcium channel blockers and cardiovascular outcomes: a meta-analysis of 175,634 patients
    Pierluigi Costanzo
    Department of Internal Medicine, Cardiovascular Sciences and Immunology, Federico II University, Via S Pansini, Naples, Italy
    J Hypertens 27:1136-51. 2009
    ....
  85. ncbi The role of T-type calcium channels in epilepsy and pain
    M T Nelson
    Department of Anesthesiology, University of Virginia, Charlottesville, VA 22908, USA
    Curr Pharm Des 12:2189-97. 2006
    ..Considering the important role T-channels play in the thalamus, it is likely that T-channel mutations also contribute to a wider range of disorders characterized by thalamocortical dysrhythmia...
  86. ncbi Systemic administration of nilvadipine delays photoreceptor degeneration of heterozygous retinal degeneration slow (rds) mouse
    Kimio Takeuchi
    Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Exp Eye Res 86:60-9. 2008
    ....
  87. ncbi Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors
    C C Felder
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Mol Pharmacol 48:443-50. 1995
    ..Except for its inability to couple to the modulation of Q-type calcium channels or inwardly rectifying potassium channels, the CB1 and CB2 receptors display similar pharmacological and biochemical properties...
  88. ncbi Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial
    Stevo Julius
    University of Michigan, Ann Arbor, USA
    Lancet 363:2022-31. 2004
    ....
  89. pmc Interaction of SNX482 with domains III and IV inhibits activation gating of alpha(1E) (Ca(V)2.3) calcium channels
    E Bourinet
    Physiopathologie des Canaux Ioniques, Institut de Genetique Humaine, CNRS UPR1142, 34396 Montpellier Cedex 5, France
    Biophys J 81:79-88. 2001
    ..We conclude that SNX482 does not exhibit unequivocal specificity for R-type channels, but highly effectively antagonizes their activation...
  90. ncbi Evaluation of tracer kinetic models for quantification of P-glycoprotein function using (R)-[11C]verapamil and PET
    Mark Lubberink
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:424-33. 2007
    ....
  91. ncbi Role of L-type Ca2+ channels in neural stem/progenitor cell differentiation
    Marcello D'Ascenzo
    Institute of Human Physiology, Medical School, Catholic University S Cuore, Largo F Vito 1, I 00168 Rome, Italy
    Eur J Neurosci 23:935-44. 2006
    ....
  92. ncbi The utility of hERG and repolarization assays in evaluating delayed cardiac repolarization: influence of multi-channel block
    Ruth L Martin
    Department of Integrative Pharmacology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6119, USA
    J Cardiovasc Pharmacol 43:369-79. 2004
    ....
  93. ncbi Cellular mechanisms of the slow (<1 Hz) oscillation in thalamocortical neurons in vitro
    Stuart W Hughes
    School of Biosciences, Cardiff University, Museum Avenue, CF10 3US, Cardiff, United Kingdom
    Neuron 33:947-58. 2002
    ..These results suggest an active role for the thalamus in shaping the slow (<1 Hz) sleep rhythm...
  94. ncbi TRPC6 is a candidate channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells
    Silke Jung
    Institut fur Pharmakologie, Freie Universitat Berlin, 14195 Berlin, Germany
    Am J Physiol Cell Physiol 282:C347-59. 2002
    ..Northern hybridization revealed mRNA coding for TRPC1 and TRPC6. We therefore suggest that TRPC6 is a molecular component of receptor-stimulated Ca(2+)-permeable cation channels in A7r5 smooth muscle cells...
  95. ncbi Long-term effects of calcium antagonists on augmentation index in hypertensive patients with chronic kidney disease: a randomized controlled study
    Tsuneo Takenaka
    Department of Nephrology, Saitama Medical University, Faculty of Medicine, Moroyama, Japan takenaka saitama med ac jp
    Am J Nephrol 35:416-23. 2012
    ..Our previous retrospective study showed that benidipine was superior to amlodipine (AM) for reducing proteinuria and preserving the augmentation index (AI) in patients with chronic kidney disease (CKD)...
  96. ncbi Scaffold-based design and synthesis of potent N-type calcium channel blockers
    Gerald W Zamponi
    Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
    Bioorg Med Chem Lett 19:6467-72. 2009
    ..We have optimized their scaffolds to obtain more selective N-type calcium channel blockers. During this optimization, we discovered NP118809 and NP078585, two potent N-type calcium channel ..
  97. ncbi Sex-related differences in pharmacokinetics and pharmacodynamics of anti-hypertensive drugs
    Koichi Ueno
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chuo Ku, Chiba, Japan
    Hypertens Res 35:245-50. 2012
    ..There are still large gaps in our knowledge of sex-specific differences in clinical pharmacology and much more research is needed...
  98. ncbi Targeting Ca2+ release-activated Ca2+ channel channels and leukotriene receptors provides a novel combination strategy for treating nasal polyposis
    Joseph Di Capite
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    J Allergy Clin Immunol 124:1014-21.e1-3. 2009
    ..Polyps are rich in mast cells and eosinophils, resulting in high levels of the proinflammatory cysteinyl leukotrienes...
  99. ncbi A high-throughput assay for evaluating state dependence and subtype selectivity of Cav2 calcium channel inhibitors
    Ge Dai
    Merck Research Laboratories, Rahway, NJ 07065, USA
    Assay Drug Dev Technol 6:195-212. 2008
    ....
  100. pmc Intraretinal calcium channels and retinal morbidity in experimental retinopathy of prematurity
    Bruce A Berkowitz
    Department of Anatomy and Cell Biology, Wayne State University, Detroit, MI, USA
    Mol Vis 17:2516-26. 2011
    ..To test the hypothesis that intraretinal calcium channels participate in retinal morbidity in a variable oxygen (VO) model of retinopathy of prematurity...
  101. pmc INVEST revisited: review of findings from the International Verapamil SR-Trandolapril Study
    Rhonda M Cooper-Dehoff
    University of Florida College of Pharmacy, Department of Pharmacotherapy and Translational Research, 1600 SW Archer Road, Box 100486, Gainesville, FL 32610 0486, USA
    Expert Rev Cardiovasc Ther 7:1329-40. 2009
    ..g., risk for diabetes) and not necessarily that any one drug be given to all...

Research Grants62

  1. Mechanisms and translation of lipid resuscitation
    Guy L Weinberg; Fiscal Year: 2013
    ..for a geriatric population to adhere to instructions for such prescription drugs as long acting calcium channel blockers that can be potentially fatal in overdose...
  2. Comparative safety &effectiveness of antihypertensive medications in pregnancy
    BRIAN THOMAS BATEMAN; Fiscal Year: 2013
    ..pregnancy outcomes compared to other classes of agents including alpha-beta blockers, beta blockers, and calcium channel blockers. Yet, for each of these other classes, important fetal safety concerns have been raised...
  3. Udall Parkinson's Disease Center at Emory University: Circuitry to Therapy
    THOMAS N WICHMANN; Fiscal Year: 2013
    ..thalamic cellular properties (M1 and M4 muscarinic receptor agonists or antagonists or selective Cav3 calcium channel blockers) can be used to reduce the transmission of pathological activity from the basal ganglia through thalamus ..
  4. Molecular Biology of Marfan Syndrome
    Harry C Dietz; Fiscal Year: 2013
    ..Aim 2 will exploit our recent observation that calcium channel blockers (CCBs) rapidly accelerate vascular disease in MFS mice...
  5. Longitudinal Impact of Antihypertensive Polypharmacy on Geriatric Syndromes
    Joseph T Hanlon; Fiscal Year: 2012
    ..defined as medications from the following eight classes: 1) beta blockers;2) peripheral alpha blockers;3) calcium channel blockers;4) angiotensin converting enzyme inhibitors;5) angiotensin receptor blockers;6) direct vasodilators;7) ..
  6. MicroRNA to decrease vascular CaV1.2 in hypertension
    Philip T Palade; Fiscal Year: 2013
    ..While there are numerous short-acting medications (including calcium channel blockers) to treat hypertension, most patients do not take their medications faithfully and consequently less than ..
  7. Manganese-Enhanced MRI Studies of Vision Loss with Aging
    DAVID PHILIP BISSIG; Fiscal Year: 2013
    ..group would support previous findings of neuroprotective effects of dihydropyridine L-type calcium channel blockers. These experiments will clarify the hypothesized link between age-related changes in neuronal ion ..
  8. Longitudinal Impact of Antihypertensive Polypharmacy on Geriatric Syndromes
    Joseph T Hanlon; Fiscal Year: 2010
    ..use of 2 or more medications from any of seven medication classes: 1) beta blockers;2) alpha blockers;3) calcium channel blockers;4) angiotensin converting enzyme inhibitors;5) angiotensin receptor blockers;6) direct vasodilators;and 7)..
  9. Calcium-related Neurotoxicity of Cocaine
    Yingtian Pan; Fiscal Year: 2013
    ..In addition, we will examine the efficacy of calcium channel blockers in preventing cocaine-induced increases in intracellular Ca2+ content, as a potential therapeutic ..
  10. TRP Channel Mediated Pain Circuitry
    Clifford J Woolf; Fiscal Year: 2013
    ..ion channels can be used to silence primary sensory neurons, but by using delivery of cationic calcium channel blockers to disrupt vesicle release in the periphery to reduce neurogenic inflammation and in the spinal cord to ..
  11. Pharmaconeuropathology of Brain Aging and Dementia
    Joshua A Sonnen; Fiscal Year: 2013
    ..therapy in women, two subclasses of antihypertensive drugs with proposed neuroprotective actions (calcium channel blockers and angiotensin-converting enzyme inhibitors), and level of physical exercise...
  12. Comparative Effectiveness of ACE Inhibitors for African Americans
    GBENGA GODWIN OGEDEGBE; Fiscal Year: 2011
    ..often in African Americans compared to Caucasians;2) more often than !-blockers, thiazide diuretics, or calcium channel blockers among nondiabetic African Americans;and 3) the incremental cost-effectiveness of ACE inhibitors will be ..
  13. MVPS: Health Concerns, Role function, Health Service Use
    KRISTINE SCORDO; Fiscal Year: 2002
    ..symptoms, anxiety, social support, diet (magnesium, sodium, water and caffeine), and treatment (beta and calcium channel blockers; anxiolytics; mediation/relaxation therapy; fluid; exercise; activity limitation)? (3) What is the ..
  14. CALCIUM CHANNEL BLOCKERS--KINETICS, ACTION & METABOLISM
    STEPHEN BAI; Fiscal Year: 1992
    Over the past decade there has been a tremendous increase in the use of the calcium channel blockers in the treatment of a variety of cardiovascular diseases...
  15. ISCHEMIA-REPERFUSION INJURY AFTER LUNG TRANSPLANTATION
    Joel Cooper; Fiscal Year: 1991
    ..Significant extension of preservation time (to say 12 hrs) would increase the number of possible transplants for patients with otherwise fatal pulmonary illnesses...
  16. MOLECULAR MODE OF ACTION OF BACTERIAL ENTEROTOXINS
    JOHNNY PETERSON; Fiscal Year: 1999
    ..in the mechanism of action of CT have also been proposed, because CT-induced secretion is diminished by calcium channel blockers and CT elicits the synthesis of LTC4, a Ca++ channel activator...
  17. Cardiac Channels: Targets of Drugs that Affect Kinetics
    Dorothy A Hanck; Fiscal Year: 2010
    ..Drugs that affect blood pressure are important therapeutic agents, and calcium channel blockers have been validated in a number of large clinical trials as effective in not only lowering blood pressure ..
  18. EFFECTS OF DIFFERENTIAL COST SHARING IN THE ELDERLY
    Stephen Soumerai; Fiscal Year: 1999
    ..of DCS for blood pressure lower drugs, specifically angiotensin converting enzyme inhibitors (ACEI) and calcium channel blockers (CCB), on drug utilization and drug switching in elderly recipients of these drugs (N approximately 160,..
  19. BIOACTIVE COMPOUNDS AND MEMBRANE PROTEINS
    Koji Nakanishi; Fiscal Year: 2000
    ..While different calcium channel blockers have been described in past years, a true blocker for the main calcium-dependent action potential in ..
  20. BASIS OF SYNAPTIC PATHOLOGY IN ALZHEIMERS DISEASE
    Eliezer Masliah; Fiscal Year: 2001
    ..line (HNT) after treatment with APP, LRP blockers, protein kinase C (PKC) inhibitors and stimulators, and calcium channel blockers. They hypothesize that APP binding to LRP triggers, in addition to the internalization of the ligand, the ..
  21. EVALUATION OF RISK FACTORS FOR BARRETT'S ESOPHAGUS
    Douglas Corley; Fiscal Year: 2001
    ..g. calcium channel blockers, beta-agonists, anticholinergic agents) than do controls. B...
  22. CELLULAR CONCOMITANTS OF VINCRISTINE RESISTANCE
    JUNE BIEDLER; Fiscal Year: 1992
    ..3) Calcium channel blockers have been shown to override multidrug resistance and, in the case of verapamil, to displace vinblastine- ..
  23. MOLECULAR GENETIC ANALYSIS OF CALCIUM CHANNELS
    Linda Hall; Fiscal Year: 2005
    ..addressed is: "What is the molecular nature of binding domains for the therapeutically important organic calcium channel blockers?" This question will be addressed by defining the pharmacological profile for the newly cloned Drosophila ..
  24. PROTEIN KINASE C & CELL CYCLE IN VASCULAR INJURY
    Carolyn Smith; Fiscal Year: 1999
    ..Protein kinase C (PKC) inhibitors and calcium channel blockers are known to modulate SMC proliferation in vitro, and the latter compounds reduce proliferation following ..
  25. ION CHANNELS AND AIRWAY SMOOTH MUSCLE ACTIVATION
    Cornelis van Breemen; Fiscal Year: 1991
    ....
  26. CALCIUM CHANNEL BLOCKERS IN BREAST CANCER ETIOLOGY
    Janet Daling; Fiscal Year: 2001
    ..Women of this age also commonly suffer from hypertension or coronary disease, and calcium channel blockers (CCBs) are often used to treat either of these conditions...
  27. HYPOTHERMIC CARDIAC ARREST AND PERINATAL BRAIN DAMAGE
    ROBERT VANNUCCI; Fiscal Year: 1992
    ..extent of brain damage during hypothermic cardiac arrest will include barbiturates (thiopental sodium), calcium channel blockers (flunarazne and/or nimodipin) and the xanthine oxidase inhibitor allopurinol...
  28. MODULATION OF CALCIUM CHANNELS BY ETHANOL
    John Woodward; Fiscal Year: 1993
    ..types (L,N,T) of calcium channels in brain which exhibit different sensitivities to blockade by organic calcium channel blockers. An unequal distribution of multiple calcium channel subtypes throughout the brain may account for brain ..
  29. ETIOLOGY OF CATARACT
    NANCY RAFFERTY; Fiscal Year: 1993
    ..Antibodies against spectrin, ankyrin, vinculin, tubulin and vimentin will be used in these studies. Animals: Rabbits...
  30. ROLE OF EXTRACELLULAR K+ AND CA2+ CHANNELS IN LTP
    TIMOTHY TEYLER; Fiscal Year: 1993
    ..influx appears to be unaffected by the NMDA antagonist APV, but is abolished by specific dihydropyridine calcium channel blockers. Thus, our preliminary results indicate that postsynaptic depolarization can promote a non-NMDA, voltage-..
  31. CA CHANNELS IN THALAMIC & HIPPOCAMPAL RHYTHMIC ACTIVITY
    Matthew Anderson; Fiscal Year: 2004
    ..Yet, the lack of specific T-type calcium channel blockers has prevented direct tests of this hypothesis...
  32. VOLTAGE SENSITIVE CALCIUM CHANNELS IN BRAIN INJURY
    Robert Berman; Fiscal Year: 2002
    ..b>Calcium channel blockers are already in development for various forms of brain injury...
  33. PATHOPHYSIOLOGY AND METABOLISM OF THE LEUKOCYTE
    David Bass; Fiscal Year: 1992
    ..Specificity will be examined by the use of calcium channel blockers and the intracellular calcium chelator, TMB-8...
  34. CALCIUM CHANNEL BLOCKERS AND BREAST CANCER
    Richard Kronmal; Fiscal Year: 1999
    DESCRIPTION: Approximately seven million Americans are currently using calcium channel blockers primarily for treatment of hypertension or angina...
  35. GENETIC BASIS OF DRUG RESISTANCE IN P FALCIPARUM
    Dyann Wirth; Fiscal Year: 1991
    ..drug efflux and that this efflux can be reversed by simultaneous incubation with verapamil and other calcium channel blockers. These observations are reminiscent of a similar phenomenon in mammalian cells, namely the multi-drug ..
  36. CALCIUM AND EPITHELIAL TRANSPORT
    Wadi Suki; Fiscal Year: 1990
    ..These studies should provide a better understanding of the role of calcium on various transport processes in the mammalian nephron...
  37. FUNCTIONAL ROLE OF GP150-180 IN MULTIDRUG RESISTANCE
    AHMAD SAFA; Fiscal Year: 1991
    ..examine the role of gp150-180 in multidrug resistance (MDR) and its role in the circumvention of MDR by calcium channel blockers. A major 150-180 kDa Vinca alkaloid (gp150-180) was identified in purified plasma membranes from MDR ..
  38. RENAL GROWTH/DURING URETERAL OBSTRUCTION
    Ihor Sawczuk; Fiscal Year: 1993
    ..In either case, it is a fascinating marker of tissue degeneration and atrophy. Antibodies will be produced in order to determine its cellular localization and other physical characteristics of the TRPM-2 protein product...
  39. CELLULAR MECHANISMS OF ALCOHOL INJURY OF GASTRIC MUCOSA
    Andrzej Tarnawski; Fiscal Year: 1991
    ..05-4 mM) plus alcohol with and without calcium ionophore and/or calcium channel blockers or calmodulin antagonists...
  40. Exploring the Mechanisms of Photoreceptor Degeneration
    Alaron Lewis; Fiscal Year: 2009
    ..Indicators include the GCaMP family of probes and the TN-XXL FRET-based indicator. Calcium channel blockers and mutants will be tested for their ability to prevent calcium accumulation and apoptosis...
  41. Development and Testing of a Neuroprotective Solution
    Yanming Wang; Fiscal Year: 2003
    ..compounds with disparate mechanisms of action have been considered, from oxygen free radical scavengers, calcium channel blockers, glutamate receptor antagonists to monoclonal antibodies that attempt to curtail inflammatory cascades ..
  42. CALCIUM & ESTROGEN ACTION IN HUMAN BREAST CANCER
    Jeannine Strobl; Fiscal Year: 1991
    ..Sp. Aim 2 is to determine the effects of calmodulin inhibitors, calcium channel blockers, and a protein kinase C inhibitor on MCF-7 estrogen receptor,levels and binding affinities, to determine ..
  43. REGULATION OF INTRACELLULAR CALCIUM IN RENAL CELLS
    ROGER O NEIL; Fiscal Year: 2002
    ..states are known to activate Ca+ influx through purported Ca+ channels as the influx can be abolished by calcium channel blockers (e.g. Dihydropyridines (DHP), L-type Ca+ channel blocker)...
  44. STURGE WEBER SYNDROME CONSENSUS CONFERENCE
    Harry Chugani; Fiscal Year: 1999
    ..b>Calcium channel blockers, aspirin and excitatory aminoacid receptor antagonists have all been suggested as promising agents in ..
  45. IONIC CURRENTS AND (CA++)I IN CORONARY SMOOTH MUSCLE
    James Johns; Fiscal Year: 1992
    ..b>Calcium channel blockers are widely used for the treatment of angina, hypertension, arrhythmias, and other diseases, and yet many ..
  46. INITIATING MECHANISMS OF LIGHT DAMAGE IN THE RETINA
    Barry Winkler; Fiscal Year: 1992
    ..in the intracellular concentration of calcium and to determine the mechanism of this increase using calcium channel blockers, ionophores, and divalent ion substitutes; and 4) To determine whether rhodopsin bleaching is associated ..
  47. Dendritic Role in Dopamine Neuron Firing
    Joseph Callaway; Fiscal Year: 2004
    ..b>Calcium channel blockers will be used in conjunction with calcium imaging to establish the types and distribution of calcium ..
  48. REDUCTION OF INFARCT SIZE AFTER SURGICAL REPURFUSION
    Lawrence Cohn; Fiscal Year: 1990
    ..mechanisms of their action, 2) thromboxane synthetase inhibitors in both the acute and chronic model, 3) calcium channel blockers and 4) agents that increase oxygen delivery to the ischemic myocardium, oxygenated crystalloid ..
  49. RCT to Reduce Prescribing Errors in Hypertension
    Stephen Soumerai; Fiscal Year: 2003
    ..Prescribing calcium channel blockers for hypertension, for example, instead of firstline, evidence-based agents such as diuretics and beta ..
  50. Sixth International Marfan Syndrome Symposium
    Peter Byers; Fiscal Year: 2001
    ..The fourth will be devoted to issues in medical therapy, including the use of P-blockers, calcium channel blockers, and inhibitors of matrix degradation to slow the rate of aortic enlargement, the major risk factor for ..
  51. DEVELOPMENT OF ANTIMETASTATIC THERAPY AND MODELS
    Ralph Bernacki; Fiscal Year: 1992
    ..includes testing a series of synthetic sugar analogs, oligosaccharides, nucleotide-sugar derivatives, calcium channel blockers and calmodulin inhibitors for their effects on tumor cell attachment and growth...
  52. VARIANT CELLS RESISTANT TO DIVERSE CYTOTOXIC AGENTS
    Susan Wright; Fiscal Year: 1991
    ..The mechanism of drug resistance will be examined by testing for reversal of resistance with calcium channel blockers and calmodulin inhibitors and measuring drug uptake and efflux...
  53. MOLECULAR ARCHITECTURE OF AN ACTIVE ZONE OF EXOCYTOSIS
    JULIO FERNANDEZ; Fiscal Year: 1999
    ..By combining immunocytochemistry, PCR cloning, pulse laser imaging, patch clamp recording and specific calcium channel blockers, the investigator will attempt to determine which calcium channel type is specifically localized at the ..
  54. NSAIDS and Other Medications in Prostate Cancer Etiology
    Janet Stanford; Fiscal Year: 2005
    ..Results of the study may provide unique insights on the pathogenesis of this complex disease and lead to innovative strategies for prostate cancer prevention. ..
  55. GLUCOCORTICOID REGULATION OF MEMORY IN AGING HUMANS
    John Newcomer; Fiscal Year: 2003
    ..g., GC receptor antagonists, calcium channel blockers) for preventing this adverse effect on memory.
  56. NEUROPROTECTIVE DRUGS IN GLAUCOMA
    Thomas Mittag; Fiscal Year: 2001
    ..The PI will evaluate receptor antagonists, calcium channel blockers, anti-apoptosis agents, antioxidants and oxyradical traps, antiproteases, and nitric oxide synthase ..
  57. MAGNETIC FIELDS, MEDICATIONS, AND BREAST CANCER
    Scott Davis; Fiscal Year: 2000
    ..cancer in women who have regularly taken selected types of prescription medications (beta blockers, calcium channel blockers, psychotropics) in the ten years prior to diagnosis (or reference date for controls)...
  58. ROLE OF CALCIUM IN PLATELET ACTIVATING FACTOR ACTION
    RAMADAN SHA AFI; Fiscal Year: 1991
    ..Third, we plan to characterize the effects of calcium channel blockers on binding of platelet-activating factor and the biochemical changes it produces.
  59. Ca2+ activated K+ channels regulate Purkinje cell firing
    JEREMY EDGERTON; Fiscal Year: 2003
    ..Electrophysiological methods will be used to examine the consequences of calcium channel blockers on Purkinje cell Kca activity.
  60. EPILEPSY RESEARCH: STUDIES OF CHRONIC EPILEPTIC FOCI
    PHILIP SCHWARTZKROIN; Fiscal Year: 1991
    ..to seek functional correlates of the calcium channel studies will carry out electromicroscopic examination of intracellular calcium distribution; and will examine the effects of organic calcium channel blockers as anticonvulsant agents.
  61. A GENETIC APPROACH TO DRUG FUNCTION
    MARK CADDLE; Fiscal Year: 2002
    ..I proposal they have taken advantage of the inhibition of cellular proliferation by anti-hypertensive calcium channel blockers to isolate gene products that are important to the action of these drugs...
  62. GENETIC APPROACH TO DRUG FUNCTION
    DOUGLAS CONKLIN; Fiscal Year: 1999
    ..Investigator will take advantage of the inhibition of cellular proliferation by anti-hypertensive calcium channel blockers to isolate gene products that are important to the action of these drugs...