anticarcinogenic agents

Summary

Summary: Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved. They differ from antineoplastic agents in that they prevent neoplasms from forming. The anticarcinogenic substances can be divided into three categories. The first consists of compounds that prevent the formation of carcinogens from precursor substances. The second group consists of "blocking agents" which inhibit carcinogenesis by preventing carcinogenic agents from reaching or reacting with critical target sites in the tissues. The third group is the "suppressor agents" which act by suppression of expression of neoplasia in cells previously exposed to carcinogens that would otherwise cause neoplasms.

Top Publications

  1. ncbi Cancer chemoprevention with dietary phytochemicals
    Young Joon Surh
    College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Nat Rev Cancer 3:768-80. 2003
  2. ncbi Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines
    Ming Zhu Fang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Cancer Res 63:7563-70. 2003
  3. pmc BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer
    Shahana Majid
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, CA 94121, USA
    Carcinogenesis 30:662-70. 2009
  4. pmc Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression
    Nam Joo Kang
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Carcinogenesis 30:321-30. 2009
  5. ncbi Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium
    D Z Chen
    North Shore-Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    J Nutr 131:3294-302. 2001
  6. ncbi A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase
    Melinda C Myzak
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Cancer Res 64:5767-74. 2004
  7. pmc Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms
    Mohammad Athar
    Departments of Dermatology, Columbia University Medical Center, Irving Cancer Research Center, New York, NY 10032, USA
    Arch Biochem Biophys 486:95-102. 2009
  8. ncbi Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models
    K P Bhat
    Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Cancer Res 61:7456-63. 2001
  9. ncbi Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells
    Anna Herman-Antosiewicz
    Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Res 66:5828-35. 2006
  10. ncbi Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway
    Yiwei Li
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Cancer Res 8:2369-77. 2002

Research Grants

Detail Information

Publications339 found, 100 shown here

  1. ncbi Cancer chemoprevention with dietary phytochemicals
    Young Joon Surh
    College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Nat Rev Cancer 3:768-80. 2003
    ....
  2. ncbi Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines
    Ming Zhu Fang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Cancer Res 63:7563-70. 2003
    ....
  3. pmc BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer
    Shahana Majid
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, CA 94121, USA
    Carcinogenesis 30:662-70. 2009
    ..Genistein being a natural, non-toxic, dietary isoflavone is effective in retarding the growth of RCC cells, making it a promising candidate for epigenetic therapy in renal carcinoma...
  4. pmc Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression
    Nam Joo Kang
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Carcinogenesis 30:321-30. 2009
    ..These results suggested that this compound could act as a potent chemopreventive agent against skin cancer...
  5. ncbi Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium
    D Z Chen
    North Shore-Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    J Nutr 131:3294-302. 2001
    ....
  6. ncbi A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase
    Melinda C Myzak
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Cancer Res 64:5767-74. 2004
    ..Collectively, these findings suggest that SFN may be effective as a tumor-suppressing agent and as a chemotherapeutic agent, alone or in combination with other HDAC inhibitors currently undergoing clinical trials...
  7. pmc Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms
    Mohammad Athar
    Departments of Dermatology, Columbia University Medical Center, Irving Cancer Research Center, New York, NY 10032, USA
    Arch Biochem Biophys 486:95-102. 2009
    ..This review summarizes in vitro mechanistic data available for resveratrol and discusses new potential anti-cancer targets and the antiproliferative mechanisms of resveratrol...
  8. ncbi Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models
    K P Bhat
    Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Cancer Res 61:7456-63. 2001
    ..In rodent models, carcinogen-induced preneoplastic lesions and mammary tumors are inhibited. These data suggest that resveratrol may have beneficial effects if used as a chemopreventive agent for breast cancer...
  9. ncbi Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells
    Anna Herman-Antosiewicz
    Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Res 66:5828-35. 2006
    ..To the best of our knowledge, the present study is the first published report to convincingly document induction of autophagy by an isothiocyanate class of dietary chemopreventive agent...
  10. ncbi Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway
    Yiwei Li
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Cancer Res 8:2369-77. 2002
    ....
  11. pmc Resveratrol: a review of preclinical studies for human cancer prevention
    Mohammad Athar
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street VC15 204, New York, NY 10032, USA
    Toxicol Appl Pharmacol 224:274-83. 2007
    ..This review discusses the current preclinical and mechanistic data available and assesses resveratrol's anticancer effects to support its potential as an anticancer agent in human populations...
  12. ncbi Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancer cells in vitro and inhibits tumor growth in vivo
    Yu Bai
    Department of Urology, First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, China
    Cancer Sci 101:488-93. 2010
    ..These findings suggest that reveratrol could be an important chemoprevention agent for bladder cancer...
  13. ncbi Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9
    Sanjeev Banerjee
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 62:4945-54. 2002
    ..Overall, our results suggest that resveratrol suppresses DMBA-induced mammary carcinogenesis, which correlates with down-regulation of NF-kappaB, cyclooxygenase-2, and matrix metalloprotease-9 expression...
  14. pmc Multi-targeted prevention of cancer by sulforaphane
    John D Clarke
    Department of Nutrition and Exercise Sciences, 117 Milam Hall, Oregon State University, Corvallis, OR 97331, USA
    Cancer Lett 269:291-304. 2008
    ..The current status of SFN in human clinical trials also is included, with consideration of the chemistry, metabolism, absorption and factors influencing SFN bioavailability...
  15. pmc Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis
    Jane V Higdon
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Pharmacol Res 55:224-36. 2007
    ....
  16. pmc Introducing nanochemoprevention as a novel approach for cancer control: proof of principle with green tea polyphenol epigallocatechin-3-gallate
    Imtiaz A Siddiqui
    Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Cancer Res 69:1712-6. 2009
    ..Thus, this study could serve as a basis for the use of nanoparticle-mediated delivery to enhance bioavailability and limit any unwanted toxicity of chemopreventive agents, such as EGCG...
  17. ncbi Genistein attenuates WNT signaling by up-regulating sFRP2 in a human colon cancer cell line
    Yukun Zhang
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Exp Biol Med (Maywood) 236:714-22. 2011
    ..Genistein inhibits β-catenin-mediated WNT signaling through increasing sFRP2 gene expression by demethylating its silenced promoter in colon cancer cell line DLD-1...
  18. ncbi Dietary genistein inhibits metastasis of human prostate cancer in mice
    Minalini Lakshman
    Division of Hematology Oncology, Department of Medicine, Northwestern University Medical School and Robert H Lurie Cancer Center of Northwestern University, Chicago, Illinois, USA
    Cancer Res 68:2024-32. 2008
    ..Increases in promotility proteins support the notion of cellular compensatory responses to antimotility effects induced by therapy. Studies of antimetastatic efficacy in man are warranted and are under way...
  19. ncbi Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans
    C Clifford Conaway
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, NY 10595, USA
    Curr Drug Metab 3:233-55. 2002
    ..Finally, based on recent epidemiological studies, the role of dietary consumption of vegetables containing ITCs in prevention of human cancers and human cancer susceptibility is discussed...
  20. ncbi Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials
    Bernard F Cole
    Department of Mathematics and Statistics, University of Vermont, Burlington, VT 05401, USA
    J Natl Cancer Inst 101:256-66. 2009
    ..A meta-analysis of these trials will provide more precise estimates of the aspirin effect, both overall and in subgroups...
  21. ncbi Resveratrol addiction: to die or not to die
    Mehdi Shakibaei
    Institute of Anatomy, Ludwig Maximilian University Munich, Munich, Germany
    Mol Nutr Food Res 53:115-28. 2009
    ..These attributes of resveratrol are discussed in detail in this review...
  22. ncbi The cancer chemopreventive actions of phytochemicals derived from glucosinolates
    John D Hayes
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Eur J Nutr 47:73-88. 2008
    ..Certain indoles act as ligands for AhR. Isothiocyanates and indoles are also capable of affecting cell cycle arrest and stimulating apoptosis. The mechanisms responsible for these anti-proliferative responses are discussed...
  23. ncbi Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion
    Huawei Zeng
    United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, P O Box 9034, Grand Forks, ND 58202 9034, USA
    J Nutr Biochem 19:1-7. 2008
    ..This article reviews the status of knowledge concerning selenium metabolism and its anticancer effects with particular reference to the modulation of cell proliferation and the inhibition of tumor cell invasion...
  24. pmc Superior in vivo inhibitory efficacy of methylseleninic acid against human prostate cancer over selenomethionine or selenite
    Guang Xun Li
    Hormel Institute, University of Minnesota, 801 16th Avenue Northeast, Austin, MN 55912, USA
    Carcinogenesis 29:1005-12. 2008
    ..In summary, our data demonstrated superior in vivo growth inhibitory efficacy of MSeA over SeMet and selenite, against two human PCa xenograft models without the genotoxic property of selenite...
  25. ncbi Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells
    Sayaka Kanematsu
    Department of Pathology II, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    Anticancer Res 30:3381-90. 2010
    ..The involvement of autophagy in the SFN-induced apoptotic death of human breast cancer cells was investigated...
  26. ncbi Cancer preventive properties of ginger: a brief review
    Yogeshwer Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226 001, Uttar Pradesh, India
    Food Chem Toxicol 45:683-90. 2007
    ..A number of mechanisms that may be involved in the chemopreventive effects of ginger and its components have been reported from the laboratory studies in a wide range of experimental models...
  27. ncbi Molecular targets of dietary agents for prevention and therapy of cancer
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Box 143, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Biochem Pharmacol 71:1397-421. 2006
    ..This work reaffirms what Hippocrates said 25 centuries ago, let food be thy medicine and medicine be thy food...
  28. ncbi Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis
    T Fotsis
    Division of Hematology and Oncology, Children s Hospital, Ruprecht Karls University, Heidelberg, Germany
    Cancer Res 57:2916-21. 1997
    ....
  29. ncbi Pinostrobin from honey and Thai ginger (Boesenbergia pandurata): a potent flavonoid inducer of mammalian phase 2 chemoprotective and antioxidant enzymes
    Jed W Fahey
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Agric Food Chem 50:7472-6. 2002
    ..110,000 units/g) is even higher than that of broccoli and the potencies of fingerroot oil and powdered rhizome (ca. 500,000 units/g) rival that of broccoli sprouts...
  30. ncbi Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea
    Jihyeung Ju
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Cancer Res 65:10623-31. 2005
    ....
  31. ncbi Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene
    Ariel Revel
    Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Toronto, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 21X5, Canada
    J Appl Toxicol 23:255-61. 2003
    ..All BaP-induced effects could be prevented by resveratrol, suggesting a possible chemopreventive role for this natural phytoalexin against the development of lung cancer...
  32. ncbi Targeting the beta-catenin/APC pathway: a novel mechanism to explain the cyclooxygenase-2-independent anticarcinogenic effects of celecoxib in human colon carcinoma cells
    Thorsten Jürgen Maier
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Frankfurt, Germany
    FASEB J 19:1353-5. 2005
    ..These findings indicate that the anticarcinogenic effects of celecoxib can be explained, at least partly, by an extensive degradation of beta-catenin in human colon carcinoma cells...
  33. ncbi 5-fluorouracil increases the chemopreventive potentials of resveratrol through DNA damage and MAPK signaling pathway in human colorectal cancer cells
    Purusottam Mohapatra
    KIIT School of Biotechnology, KIIT University, Orissa, India
    Oncol Res 19:311-21. 2011
    ..Expression levels of p-JNK and p-p38 were increased without affecting pERK. 5-FU could be used as a therapeutic modality to improve efficacy of Res-based chemotherapy against colon cancer...
  34. ncbi Regulation of p53 and cell proliferation by resveratrol and its derivatives in breast cancer cells: an in silico and biochemical approach targeting integrin αvβ3
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Int J Cancer 129:2732-43. 2011
    ....
  35. ncbi Benzo[A]pyrene-induced oral carcinogenesis and chemoprevention: studies in bioengineered human tissue
    Thomas Walle
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 173 Ashley Avenue, P O Box 250505, Charleston, SC 29425, USA
    Drug Metab Dispos 34:346-50. 2006
    ..Thus, this bioengineered oral tissue construct opens up improved ways of understanding and preventing/treating smoking-induced oral cancer...
  36. pmc Chemoprevention in familial adenomatous polyposis
    Brian Kim
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Best Pract Res Clin Gastroenterol 25:607-22. 2011
    ..Curcumin and eicosapentaenoic acid show efficacy in small clinical trials of FAP chemoprevention. This article will review the concept of chemoprevention and the current clinical literature in FAP chemoprevention...
  37. ncbi Silybin and silymarin--new and emerging applications in medicine
    Radek Gažák
    Laboratory of Biotransformation, Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídezská 1083, CZ 142 20 Prague, Czech Republic
    Curr Med Chem 14:315-38. 2007
    ..Significance of silymarin and its components in the medicine is clearly indicated by an exponential growth of publications on this topic--over 800 papers in the last 5 years...
  38. ncbi Ospemifene inhibits the growth of dimethylbenzanthracene-induced mammary tumors in Sencar mice
    Gregory T Wurz
    University of California, Davis, Department of Internal Medicine, Division of Hematology and Oncology, Cancer Center, Sacramento, 95817, USA
    J Steroid Biochem Mol Biol 97:230-40. 2005
    ..The results of these two studies suggest that women taking ospemifene for osteoporosis and/or urogenital atrophy may further benefit from ospemifene's breast cancer chemopreventive effects...
  39. pmc Enhanced anti-tumor activity by the combination of the natural compounds (-)-epigallocatechin-3-gallate and luteolin: potential role of p53
    A R M Ruhul Amin
    Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 285:34557-65. 2010
    ....
  40. ncbi Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway
    Woo Sik Jeong
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Pharm Res 21:661-70. 2004
    ..To study and compare effects of selected natural chemopreventive agents on the transcription activation of nuclear factor-kappa B (NF-kappaB) in human HT-29 colon cancer cells...
  41. ncbi Cyclooxygenase-2 (COX-2)-dependent and -independent anticarcinogenic effects of celecoxib in human colon carcinoma cells
    Thorsten Jürgen Maier
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, Frankfurt Main 60590, Germany
    Biochem Pharmacol 67:1469-78. 2004
    ..Thus, the anticarinogenic effects of celecoxib can be explained by both COX-2-dependent and -independent mechanisms...
  42. ncbi Soy, isoflavones, and prostate cancer
    Le Jian
    School of Public Health, Health Innovation Research Institute, Curtin University of Technology, Kent Street, Bentley 6102, Perth, Australia
    Mol Nutr Food Res 53:217-26. 2009
    ..In this article, epidemiological and laboratory studies on the relationship between soybeans, isoflavones and prostate cancer are reviewed and large scale multiethnic epidemiological studies are recommended...
  43. ncbi Alteration of hepatic proinflammatory cytokines is involved in the resveratrol-mediated chemoprevention of chemically-induced hepatocarcinogenesis
    Thomas Mbimba
    Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA
    Curr Pharm Biotechnol 13:229-34. 2012
    ..From the current results in conjunction with our previous findings, it can be concluded that resveratrol-mediated chemoprevention of rat liver carcinogenesis is related to alteration of proinflammatory cytokines...
  44. ncbi Daily aspirin use and cancer mortality in a large US cohort
    Eric J Jacobs
    Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303 1002, USA
    J Natl Cancer Inst 104:1208-17. 2012
    ..49 to 0.82) in overall cancer mortality during follow-up occurring after 5 years on aspirin. However, the magnitude of the effect of daily aspirin use, particularly long-term use, on cancer mortality is uncertain...
  45. pmc Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells in vitro and in vivo
    Masayuki Fukui
    Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Eur J Cancer 46:1882-91. 2010
    ..Given the widespread use of resveratrol among cancer patients, this study calls for more preclinical and clinical testing of the potential benefits and harms of using resveratrol as a dietary adjuvant in cancer patients...
  46. ncbi Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms
    E Heiss
    Deutsches Krebsforschungszentrum Heidelberg, Division of Toxicology and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 276:32008-15. 2001
    ..Our data provide novel evidence that anti-inflammatory mechanisms contribute to sulforaphane-mediated cancer chemoprevention...
  47. ncbi Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling
    G Kallifatidis
    Molecular OncoSurgery Group, University of Heidelberg and German Cancer Research Center, Heidelberg, Germany
    Gut 58:949-63. 2009
    ..The aim of the study was to identify TICs in pancreatic carcinoma for analysis of resistance mechanisms and for definition of sensitising agents...
  48. ncbi Biological activity of piceatannol: leaving the shadow of resveratrol
    Hanna Piotrowska
    Department of Toxicology, Poznan University of Medical Sciences, ul Dojazd 30, 60 631 Poznan, Poland
    Mutat Res 750:60-82. 2012
    ....
  49. ncbi COX-2: a target for colon cancer prevention
    Lawrence J Marnett
    A B Hancock Jr Memorial Laboratory for Cancer Research, Center in Molecular Toxicology, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Annu Rev Pharmacol Toxicol 42:55-80. 2002
    ..It is hoped that, as the genome sequence is understood more clearly, other targets will emerge that will provide even more effective drugs for future cancer prevention...
  50. ncbi Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues
    Michael J Thun
    Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, GA 30329 4251, USA
    J Natl Cancer Inst 94:252-66. 2002
    ..Finally, we suggest research opportunities that may help to accelerate the future clinical application of NSAIDs for cancer prevention or treatment...
  51. pmc Nanochemoprevention by bioactive food components: a perspective
    Imtiaz A Siddiqui
    Department of Dermatology, University of Wisconsin, Medical Sciences Center B 25, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Pharm Res 27:1054-60. 2010
    ....
  52. ncbi Genistein sensitizes TRAIL-resistant human gastric adenocarcinoma AGS cells through activation of caspase-3
    Cheng Yun Jin
    Department of Biological Sciences, Pusan National University, Busan 609 735, Republic of Korea
    Cancer Lett 257:56-64. 2007
    ..These results indicate that caspase-3 is a key regulator of apoptosis in response to combined genistein and TRAIL in human gastric adenocarcinoma AGS cells through the activation of DR5 and mitochondrial dysfunction...
  53. ncbi Enzyme induction and dietary chemicals as approaches to cancer chemoprevention: the Seventh DeWitt S. Goodman Lecture
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    Cancer Res 63:7005-31. 2003
    ....
  54. ncbi Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors
    Sabine Grosch
    Pharmazentrum Frankfurt, ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe, Universitat Frankfurt, Theodor Stern Kai 7, Frankfurt Main, Germany
    J Natl Cancer Inst 98:736-47. 2006
    ..We also compare the concentrations of these inhibitors used in in vitro and in vivo experiments and discuss the implications of the in vitro studies for clinical management of cancer with these drugs...
  55. ncbi Differential inhibitory effects of the polyphenol ellagic acid on inflammatory mediators NF-kappaB, iNOS, COX-2, TNF-alpha, and IL-6 in 1,2-dimethylhydrazine-induced rat colon carcinogenesis
    Syed Umesalma
    Department of Biochemistry, University of Madras, Guindy Campus, Tamil Nadu, India
    Basic Clin Pharmacol Toxicol 107:650-5. 2010
    ..In conclusion, ellagic acid demonstrates anti-inflammatory property by iNOS, COX-2, TNF-alpha and IL-6 down-regulation due to inhibition of NF-kappaB and exerts its chemopreventive effect on colon carcinogenesis...
  56. ncbi Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis
    Nicholas J West
    Section of Molecular Gastroenterology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    Gut 59:918-25. 2010
    ....
  57. ncbi Combination of curcumin and green tea catechins prevents dimethylhydrazine-induced colon carcinogenesis
    Gang Xu
    Department of Gastroenterology, 456 Hospital of PLA, 25 Wuyingshan Road, Jinan 250031, Shandong, China
    Food Chem Toxicol 48:390-5. 2010
    ..Our findings suggest that the combination of curcumin and catechins may produce a synergistic colon cancer-preventative effect that would be more potent than each of the compounds alone...
  58. ncbi Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol
    Agnes M Rimando
    Natural Products Utilization Research Unit, Agricultural Research Service, U S Department of Agriculture, P O Box 8048, University, Mississippi 38677, USA
    J Agric Food Chem 50:3453-7. 2002
    ..8 microM), suggesting antioxidant activity plays an important role in this process...
  59. ncbi Chemopreventive potential of resveratrol in mouse skin tumors through regulation of mitochondrial and PI3K/AKT signaling pathways
    Preeti Roy
    Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific and Industrial Research, India, P O Box 80, M G Marg, Lucknow, 226001, India
    Pharm Res 26:211-7. 2009
    ..To investigate the chemopreventive potential of resveratrol, a phytoalexin found in seeds and skin of grapes, berries and peanuts in 7,12 dimethyl benz(a)anthracene (DMBA) induced mouse skin tumorigenesis...
  60. ncbi Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer
    Dominique Delmas
    Laboratory of Cell and Molecular Biology, University of Burgundy, UPRES EA 2978 GDR CNRS 2583, 6 Bd Gabriel, 21000 Dijon, France
    Curr Drug Targets 7:423-42. 2006
    ..By these properties, resveratrol appears to be a good candidate in chemopreventive or chemotherapeutic strategies and is believed to be a novel weapon for new therapeutic strategies...
  61. pmc Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention
    Ka Lung Cheung
    Graduate Program in Pharmaceutical Science, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    AAPS J 12:87-97. 2010
    ..Furthermore, we will also discuss the similarities and their potential differences in the regulation of these molecular targets by PEITC and SFN...
  62. ncbi Role of chemopreventive agents in cancer therapy
    Thambi Dorai
    Comprehensive Cancer Center, Our Lady of Mercy Medical Center, New York Medical College, Bronx, NY 10466, USA
    Cancer Lett 215:129-40. 2004
    ..Thus, these chemopreventive agents have potential to be used as adjuncts to current cancer therapies...
  63. ncbi Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells
    Nobuyuki Kikuno
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, CA 94121, USA
    Int J Cancer 123:552-60. 2008
    ..These findings strengthen the understanding of how genistein may be chemoprotective in prostate cancer...
  64. ncbi Overview of mechanisms of cancer chemopreventive agents
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 591:8-15. 2005
    ..It is also possible to affect cell-adhesion molecules, to activate antimetastasis genes, and to inhibit proteases involved in basement membrane degradation...
  65. ncbi Green tea polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer cells in vitro and in vivo
    Rajesh L Thangapazham
    Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Cancer Lett 245:232-41. 2007
    ..Our results suggest that GTP and EGCG treatment inhibits proliferation and induce apoptosis of MDA-MB-231 cells in-vitro and in-vivo. All together, these data sustain our contention that GTP and EGCG have anti-tumor properties...
  66. ncbi Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration
    Xavier Vitrac
    Laboratoire de Mycologie et Biotechnologie Végétale, EA 491, Universite de Bordeaux 2, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France
    Life Sci 72:2219-33. 2003
    ..The results also suggest a wide range of target organs for cancer chemoprevention by wine polyphenols in humans...
  67. ncbi Cancer chemoprevention by resveratrol: in vitro and in vivo studies and the underlying mechanisms (review)
    Moammir H Aziz
    Department of Dermatology, University of Wisconsin Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA
    Int J Oncol 23:17-28. 2003
    ..This should be followed by human clinical trials in appropriate cancer types in suitable populations...
  68. ncbi Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop
    Clarissa Gerhauser
    Deutsches Krebstforschungszentrum, Abteilung Toxikologie und Krebsrisikofaktoren, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mol Cancer Ther 1:959-69. 2002
    ..Together, our data provide evidence for the potential application of XN as a novel, readily available chemopreventive agent, and clinical investigations are warranted once efficacy and safety in animal models have been established...
  69. ncbi Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells
    Dong Xiao
    Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Mol Cancer Ther 3:567-75. 2004
    ..Furthermore, the results of the present study point toward involvement of both caspase-8- and caspase-9-mediated pathways in apoptosis induction by PEITC...
  70. pmc Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells
    Ajay Bommareddy
    Department of Pharmacology and Chemical Biology, and University of Pittsburgh Cancer Institute, Pennsylvania, USA
    Cancer Res 69:3704-12. 2009
    ..In conclusion, the present study indicates that Atg5 plays an important role in regulation of PEITC-induced autophagic and apoptotic cell death...
  71. ncbi Anticarcinogenic effects of selenium
    G N Schrauzer
    Biological Trace Element Research Institute, San Diego, California 92121, USA
    Cell Mol Life Sci 57:1864-73. 2000
    ..In addition, exposure to Se antagonists and carcinogenic risk factors should be minimized by appropriate dietary and lifestyle changes...
  72. pmc Genistein and resveratrol, alone and in combination, suppress prostate cancer in SV-40 tag rats
    Curt E Harper
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Prostate 69:1668-82. 2009
    ....
  73. ncbi Ins and outs of dietary phytochemicals in cancer chemoprevention
    Gian Luigi Russo
    Institute of Food Sciences, National Research Council, 83100 Avellino, Italy
    Biochem Pharmacol 74:533-44. 2007
    ..Single molecules may evolve in perfect chemopreventive agents, as in the case of tamoxifen, or generate ambiguity. Resveratrol and quercetin represent two paradoxes, discussed here...
  74. ncbi Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice
    Y Kimura
    Second Department of Medical Biochemistry, School of Medicine, Ehime University, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    J Nutr 131:1844-9. 2001
    ..that the antitumor and antimetastatic activities of resveratrol might be due to the inhibition of DNA synthesis in LLC cells and the inhibition of LLC-induced neovascularization and tube formation (angiogensis) of HUVEC by resveratrol..
  75. ncbi Epigallocatechin-3-gallate inhibits the invasion of human oral cancer cells and decreases the productions of matrix metalloproteinases and urokinase-plasminogen activator
    Yung Chuan Ho
    School of Applied Chemistry, Chung Shan Medical University, Taichung, Taiwan
    J Oral Pathol Med 36:588-93. 2007
    ..Epigallocatechin- 3-gallate (EGCG), the most abundant polyphenol in green tea, has been proven to suppress colonic tumorigenesis in animal and epidemiological studies, whereas its role in the oral carcinogenesis remains to be elucidated...
  76. ncbi Green tea and cancer prevention
    Chung S Yang
    Department of Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Nutr Cancer 62:931-7. 2010
    ..This article reviews data on the cancer preventive activities of green tea polyphenols, possible mechanisms involved, and the relationship between green tea consumption and human cancer risk...
  77. ncbi Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells
    Changjiang Xu
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Oncogene 24:4486-95. 2005
    ....
  78. pmc Are isothiocyanates potential anti-cancer drugs?
    Xiang Wu
    Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenviroment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China
    Acta Pharmacol Sin 30:501-12. 2009
    ..This review summarizes the current knowledge on isothiocyanates and focuses on their role as potential anti-cancer agents...
  79. ncbi Downregulation of the cyclin D1/Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines
    F Wolter
    2nd Department of Medicine, J. W. Goethe University, 60590 Frankfurt/Main, Germany
    J Nutr 131:2197-203. 2001
    ..These findings suggest that resveratrol exerts chemopreventive effects on colonic cancer cells by inhibition of the cell cycle...
  80. pmc Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    J Biol Chem 283:22136-46. 2008
    ..This is the first study directly linking tubulin-ITC adduct formation to cell growth inhibition...
  81. ncbi Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic
    Ivana Vucenik
    Department of Medical and Research Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Nutr 133:3778S-3784S. 2003
    ..However, the effectiveness and safety of IP6 plus inositol at therapeutic doses needs to be determined in phase I and phase II clinical trials in humans...
  82. ncbi Keap1 eye on the target: chemoprevention of liver cancer
    Melinda Sue Yates
    Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Acta Pharmacol Sin 28:1331-42. 2007
    ..However, appropriately designed clinical trials will aid in this process, which can have profound impact on the incidence of HCC...
  83. ncbi Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate
    Naghma Khan
    Department of Dermatology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Cancer Res 66:2500-5. 2006
    ..This review discusses the modulations of important signaling events by EGCG and their implications in cancer management...
  84. ncbi Soy food consumption and risk of prostate cancer: a meta-analysis of observational studies
    Ye Won Hwang
    Graduate School of Public Health, Yonsei University, Seoul, Korea
    Nutr Cancer 61:598-606. 2009
    ..This systematic review suggests that soy food consumption could lower the risk of prostate cancer. This conclusion, however, should be interpreted with caution because various biases can affect the results of a meta-analysis...
  85. ncbi Activation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor alpha expression reversing invasive phenotype of breast cancer cells
    Karine Belguise
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Cancer Res 67:5763-70. 2007
    ..These results identify, for the first time, a role for FOXO3a in the inhibition of invasive phenotype in breast cancer cells with active ERalpha signaling and elucidate a novel mechanism whereby EGCG represses EMT of breast cancer cells...
  86. ncbi Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Scott M Lippman
    The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Natl Cancer Inst 97:94-102. 2005
    ....
  87. ncbi Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin
    Jung Hwan Kim
    Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 27:475-82. 2006
    ....
  88. ncbi Heating decreases epithiospecifier protein activity and increases sulforaphane formation in broccoli
    Nathan V Matusheski
    Department of Food Science and Human Nutrition, University of Illinois, 499 Bevier Hall, 905 South Goodwin Avenue, Urbana, IL 61801, USA
    Phytochemistry 65:1273-81. 2004
    ..Heating to 70 degrees C and above decreased the formation of both products in broccoli florets, but not in broccoli sprouts. The induction of QR in cultured mouse hepatoma Hepa lclc7 cells paralleled increases in sulforaphane formation...
  89. ncbi Chemoprevention by isothiocyanates: molecular basis of apoptosis induction
    Yoshimasa Nakamura
    Department of Biofunctional Chemistry, Okayama University, Okayama, Japan
    Forum Nutr 61:170-81. 2009
    ..This review addresses the biological impact of cell death induction by BITC as well as other ITCs and the involved molecules regulating signal pathways...
  90. ncbi Resveratrol arrests the cell division cycle at S/G2 phase transition
    F D Ragione
    Medical School, Second University of Naples, Naples, Italy
    Biochem Biophys Res Commun 250:53-8. 1998
    ..These data demonstrate that resveratrol causes a complete and reversible cell cycle arrest at the S phase checkpoint...
  91. pmc Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis
    L Hilakivi Clarke
    Lombardi Cancer Center, Department of Psychiatry, Georgetown University, Washington, DC 20007, USA
    Br J Cancer 80:1682-8. 1999
    ....
  92. ncbi Nrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis
    Joydeb Kumar Kundu
    College of Pharmacy, Seoul National University, 599 kwanak Ro, Kwanak Ku, Seoul 151 742, South Korea
    Pharm Res 27:999-1013. 2010
    ..Thus, Nrf2-mediated cytoprotective gene induction is an effective strategy for the chemoprevention of inflammation-associated carcinogenesis...
  93. ncbi Recent advances in chemoprevention of cancer
    W K Hong
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 80, Houston, TX 77030, USA
    Science 278:1073-7. 1997
    ....
  94. ncbi Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase
    Esperanza J Carcache-Blanco
    Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Nat Prod 66:1197-202. 2003
    ..The absolute stereochemistry of compounds 1-4 was determined from their CD data and by Mosher ester determination. All isolates obtained were evaluated in the quinone reductase induction assay...
  95. pmc Dietary cooked navy beans and their fractions attenuate colon carcinogenesis in azoxymethane-induced ob/ob mice
    Gerd Bobe
    Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    Nutr Cancer 60:373-81. 2008
    ..04; bean residue 67%, P=0.01; bean extract 87%, P=0.0003. These results suggest that both the soluble and the insoluble fraction of the extract contribute to the cancer-protective effect of cooked navy beans...
  96. pmc Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells
    Sujit Nair
    Department of Pharmaceutics, The State University of New Jersey, Piscataway, 08854, USA
    Acta Pharmacol Sin 31:1223-40. 2010
    ....
  97. ncbi The chemopreventive agent development research program in the Division of Cancer Prevention of the US National Cancer Institute: an overview
    James A Crowell
    Division of Cancer Prevention, National Cancer Institute, DHHS, Bethesda, MD 20892, USA
    Eur J Cancer 41:1889-910. 2005
    ..Continued commitment to cancer prevention will significantly reduce the economic and medical burden of cancer...
  98. pmc Sarcophine-diol, a skin cancer chemopreventive agent, inhibits proliferation and stimulates apoptosis in mouse melanoma B₁₆F₁₀ cell line
    Pawel T Szymanski
    Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD 57007, USA
    Mar Drugs 10:1-19. 2012
    ..Finally, these studies demonstrate that SD shows a very promising chemopreventive effect in melanoma B₁₆F₁₀ tumor cells...
  99. pmc Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells
    Xiang Lin Tan
    Division of Pulmonary Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    J Nutr 140:1404-10. 2010
    ..We conclude that modulation of lung cell phase II metabolism by chemopreventive agents requires cell- and agent-specific discovery and testing...
  100. ncbi Detection bias due to the effect of finasteride on prostate volume: a modeling approach for analysis of the Prostate Cancer Prevention Trial
    Yael C Cohen
    Gamida Cell Ltd, Cell Therapy Technologies, Jerusalem, Israel
    J Natl Cancer Inst 99:1366-74. 2007
    ..This possibility was investigated in an observational reanalysis of the PCPT data, with adjustment for sampling density...
  101. ncbi Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumption
    Susanne M Henning
    Department of Pathology, VA West Los Angeles, CA 90073, USA
    J Nutr 136:1839-43. 2006
    ..001) and GT (P = 0.025) consumption relative to baseline serum This is the first human study to show that tea polyphenols and theaflavins are bioavailable in the prostate where they may be active in the prevention of prostate cancer...

Research Grants62

  1. Colon and liver anticarcinogenicity by acetaminophen
    Gary Williams; Fiscal Year: 2004
    ..In addition, these experiments will provide support for the epidemiological observations of reduced cancer risk associated with the use of APAP. ..
  2. Molecular Mechanisms of Chemoprevention: NRF2 Signaling
    Thomas W Kensler; Fiscal Year: 2013
    ..Inhibition of the development of cancer by the administration of anticarcinogenic agents may offer practical alternatives for reducing human cancer burden...
  3. FAT SOLUBLE MICRONUTRIENTS IN HUMAN PLASMA AND TISSUES
    NORMAN KRINSKY; Fiscal Year: 1993
    ..We will follow the subjects over the course of time to see if there are time-dependent variations in any of the tissue pools of these micronutrients...
  4. GENE-ENVIRONMENT EFFECTS AND COLON ADENOMAS
    Henry Lin; Fiscal Year: 2000
    ..Completion of the molecular analyses is intended to provide information on the mechanism of risk due to meat and the mechanisms of protection due to cruciferous vegetables and aspirin. ..
  5. PHARMACOKINETICS OF SOYBEAN ANTICARCINOGENS
    LEE JANE LU; Fiscal Year: 1999
    ..The purpose of the studies is to determine the most efficient timing of phytoestrogen administration and the minimum effective dose for future studies of the effects of soya phytoestrogens on endogenous markers for cancer risk in women. ..
  6. SEMI-RIGID CONJUGATED POLYENES AS MODEL ANTICARCINOGENS
    William Doering; Fiscal Year: 1991
    ..and, depending on the outcome, an alert to investigate the question of which isomer or isomers are in fact the active anticarcinogenic agents. A second goal is to facilitate the testing of the known cis isomers of beta-carotene.
  7. b Carotene Isomers and Retinol as Anticarcinogens
    Chariklia Sotiriou Leventis; Fiscal Year: 2001
    ....
  8. NATURAL & SYNTHETIC COUMARINS AS ANTICARCINOGENIC AGENTS
    John DiGiovanni; Fiscal Year: 2002
    ....
  9. GENES, ANTICARCINOGENS AND COLON NEOPLASMS
    Henry Lin; Fiscal Year: 2006
    ..Results may lead to better understanding of protective mechanisms involving aspirin and nonsteroidal anti-inflammatory drugs. ..
  10. Mechanism of Anticarcinigenic Effects of Myristicin
    HASSAN AHMAD; Fiscal Year: 2004
    ..The results are expected to help us understand the Phase-II enzyme induction by myristicin and its potential in developing pharmacologically effective dietary strategies for cancer chemoprevention. ..
  11. Rapid in Vivo Assay for Oral Cancer Chemoprevention
    DENNIS SOLT; Fiscal Year: 2002
    ..abstract_text> ..
  12. Basal Cell Carcinoma:Molecular Pathogenesis & Prevention
    David Bickers; Fiscal Year: 2006
    ..It is likely that novel anti-carcinogenic agents potentially suitable for testing in the human population could be identified as a result of the studies in this proposal. ..
  13. Targeting Akt/NF-kappa beta for Pancreatic Cancer Therapy
    Fazlul Sarkar; Fiscal Year: 2007
    ..These results will provide mechanistic as well as pre-clinical data in support of our hypotheses and may open new and novel avenues for the treatment of human pancreatic cancer. ..
  14. Isothiocyanates in the Chemoprevention of Bladder Cancer
    Yuesheng Zhang; Fiscal Year: 2007
    ..Aim 5 will determine the efficacy of an orally administered ITC in inhibiting N-butyl-N- (4-hydroxybutyl)-nitrosamine-induced bladder tumorigenesis in F344 rats. ..
  15. ESOPHAGEAL ADENOCARCINOGENESIS AND ITS PREVENTION
    Chung Yang; Fiscal Year: 2007
    ..These studies are expected to fully elucidate the roles of oxidative stress and aberrant AA metabolism in the formation of EAC and help develop effective agents for its prevention. ..
  16. INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTS
    Chung Yang; Fiscal Year: 2005
    ..Jointly, we intend to make major contributions to the use of tea for the I chemoprevention of cancer. ..
  17. MECHANISTIC STUDIES ON TEA AND CARCINOGENESIS
    Chung Yang; Fiscal Year: 2005
    ..The applicant and colleagues will address key issues concerning the bioavailability and bioactivities of O-methyl, glucuronide, and sulfate derivatives and two ring-fission metabolites of tea catechins. ..
  18. Reactivation Methylation-Silenced Genes by Polyphenols
    Chung Yang; Fiscal Year: 2007
    ..5. To determine whether EGCG, alone or in combination with other agents, can prevent hypermethylation of genes and tumor development in the intestinal tumorigenesis model in the Min mice. ..
  19. Prevention of Photocarcinogenesis by antioxidant
    Santosh Katiyar; Fiscal Year: 2003
    ..abstract_text> ..
  20. Prevention of skin cancer by green tea polyphenols
    Santosh Katiyar; Fiscal Year: 2009
    ..Importantly, worldwide interest in green tea as a cancer chemopreventive agent for humans is increasing because it is non-toxic, affordable, popular beverage and is effective in a wide range of organs. ..
  21. Prevention of UV-carcinogenesis by antioxidant
    Santosh Katiyar; Fiscal Year: 2004
    ..abstract_text> ..
  22. Proanthocyanidins: Novel Skin Cancer Preventive Agent
    Santosh Katiyar; Fiscal Year: 2006
    ..Prevention of skin cancer risk will result to protect and prolong the human health and lives. ..
  23. Chemopreventive Efficacy of Broccoli Sprouts in Humans
    Thomas Kensler; Fiscal Year: 2004
    ..abstract_text> ..
  24. Chemoprevention of Esophageal Squamous Cell Carcinoma
    Gary Stoner; Fiscal Year: 2004
    ..abstract_text> ..
  25. FLAVONOID BIOAVAILABILITY IN HUMANS-CELLULAR STUDIES
    Thomas Walle; Fiscal Year: 2005
    ..The findings from the proposed studies should help us understand the bioavailability of the flavonoids, facilitating optimization of the chemopreventive utility of these natural or synthetic compounds. ..
  26. Breast Cancer Prevention by Letrozole in High Risk Women
    Carol J Fabian; Fiscal Year: 2010
    ....
  27. CHEMOPREVENTION FOR WOMEN AT HIGH RISK OF BREAST CANCER
    CAROL FABIAN; Fiscal Year: 2003
    ..The answer impacts on the entire future of breast cancer chemoprevention development efforts. ..
  28. Breast Cancer Risk Biomarkers and Energy Balance
    CAROL FABIAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. The Proteasome as Molecular Target of Grape Polyphenols
    QING PING DOU; Fiscal Year: 2005
    ..abstract_text> ..
  30. Roles of polymorphic COMT, tea polyphenols and proteasome in cancer prevention
    QING PING DOU; Fiscal Year: 2010
    ..abstract_text> ..
  31. TEA TARGETING PROTEASOME--A ROLE IN CANCER PREVENTION
    QING DOU; Fiscal Year: 2002
    ..A Future Aim is to determine whether in vivo proteasome-inhibitory ability of tea polyphenols is related to their antitumor activity using nude mice bearing human prostate tumors. ..
  32. FlaxSeed Lignan for Breast Cancer Chemoprevention
    CAROL FABIAN; Fiscal Year: 2007
    ..If positive, the results of this study will be critical to the design and implementation of a placebo-controlled Phase II prevention trial with Brevail and/or commercial flaxseed. [unreadable] [unreadable]..
  33. Protection by Induction of Ubiquitin-Proteasome Systems
    Thomas Kensler; Fiscal Year: 2005
    ....
  34. HPLC time-of-flight mass spectrometer for accurate mass measurements
    Richard van Breemen; Fiscal Year: 2007
    ..to natural product chemists and synthetic organic chemists in the user community who rely upon rapid analyses of their compounds in order to advance with their NIH-funded research programs [unreadable] [unreadable] [unreadable]..
  35. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen S Hecht; Fiscal Year: 2010
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  36. Mechanisms of prostate cancer prevention by lycopene
    Richard van Breemen; Fiscal Year: 2007
    ..These human studies will provide vital information for the design of future clinical trials investigating the chemoprevention of prostate cancer by lycopene. [unreadable] [unreadable] [unreadable]..
  37. PREVENTION OF COLORECTAL CANCER BY iNOS AND COX-2 SELECTIVE INHIBITORS
    CHINTHALAPALLY RAO; Fiscal Year: 2008
    ..abstract_text> ..
  38. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2008
    ..abstract_text> ..
  39. RARbeta in Melanoma: Epigenetic Regulation by Nutrients
    Richard Niles; Fiscal Year: 2007
    ..Depending on results obtained, this investigation can be translated into nutritional studies with animal models of melanoma. [unreadable] [unreadable] [unreadable]..
  40. Efficacy of 25-hydroxyvitamin D3 in colon cancer chemoprevention
    Rajendra G Mehta; Fiscal Year: 2010
    ..The studies will provide a rationale for using 25(OH)D3 for the prevention of colon carcinogenesis. ..
  41. Vitamin D5 in Prevention of Mammary Carcinogenesis
    Rajendra Mehta; Fiscal Year: 2006
    ..Whether prohibitin plays a role in cell transformation and chemopreventive efficacy in these cells? 3. How is 1alpha(OH)D5 metabolized in normal and neoplastic mammary epithelial cells and tissues? ..
  42. MATRIX-ASSISTED LASER DESORPTION TOF MASS SPECTROMETER
    Richard van Breemen; Fiscal Year: 2001
    ..abstract_text> ..
  43. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
    ..abstract_text> ..
  44. Chemoprevention in Mice after Tobacco Smoke Exposure
    Hanspeter Witschi; Fiscal Year: 2004
    ..Eventually, these preclinical studies in an animal model of "former smokers" will help to evaluate the potential usefulness and also possible dosage regimens of chemopreventive agents characterized by their suppressing action. ..
  45. Resveratrol and Human Melanoma
    Richard Niles; Fiscal Year: 2004
    ..Also the information derived from the metabolism and molecular mechanism studies could provide insights into improving/maximizing the biological activity of resveratrol. ..
  46. The Bioavilaibility of Folate in Humans
    Richard van Breemen; Fiscal Year: 2004
    ..Our new LC-MS-MS assay and the use of 13C-labeled folate species will provide new and more detailed information on the uptake, metabolism, and bioavailability of folates than has been possible previously. ..
  47. 2D-HPLC-Tandem Mass Spectrometer for Proteomics
    Richard van Breemen; Fiscal Year: 2005
    ..Overall, the proposed 2D mu LC-MS/MS instrument will complement the existing proteomics resources on campus and will enhance the current research of NIH-funded users by providing analytical capabilities currently unavailable on campus. ..
  48. Cohort Study of Risks for Benign Prostatic Hyperplasia
    Alan Kristal; Fiscal Year: 2005
    ..Results from this study will enhance our understanding of the etiology of symptomatic BPH and could potentially be used to develop new strategies for prevention and control of this very common disease. ..
  49. MECHANISMS FOR CHEMOPREVENTION OF COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2004
    ..Tissue distribution and comparative metabolism studies of curcumin and PEMC will be studied with synthetic [3H] curcumin and [3H]-PEMC in vivo in male F-344 rats. ..
  50. Tobacco Carcinogenesis
    Stephen Hecht; Fiscal Year: 2005
    ..Steven Tannenbaum (MIT), Dr. Jack Henningfield (Johns Hopkins and Pinney Associates), Drs. Jeffrey Seeman and Anthony Tricker (Philip Morris), and Dr. John Lauterbach (an independent consultant, formerly with Brown and Williamson). ..