local anti infective agents

Summary

Summary: Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.

Top Publications

  1. ncbi Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Infection Control Programme
    D Pittet
    Department of Internal Medicine, University of Geneva Hospitals, and Institute of Social and Preventive Medicine, University of Geneva, Switzerland
    Lancet 356:1307-12. 2000
  2. ncbi Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America/Association for Prof
    John M Boyce
    Hospital of Saint Raphael, New Haven, Connecticut, USA
    MMWR Recomm Rep 51:1-45, quiz CE1-4. 2002
  3. pmc Epidemiologic background of hand hygiene and evaluation of the most important agents for scrubs and rubs
    Gunter Kampf
    Bode Chemie GmbH and Co, Scientific Affairs, Melanchthonstrasse 27, 22525 Hamburg, Germany
    Clin Microbiol Rev 17:863-93, table of contents. 2004
  4. ncbi Consumer antibacterial soaps: effective or just risky?
    Allison E Aiello
    Department of Epidemiology and Center for Social Epidemiology and Population Health, University of Michigan, Ann Arbor, Ann Arbor, MI 48104 2548, USA
    Clin Infect Dis 45:S137-47. 2007
  5. ncbi Triclosan: a review of effectiveness and safety in health care settings
    R D Jones
    Scientific and Regulatory Consultants, Inc, Columbia City, IN 46725, USA
    Am J Infect Control 28:184-96. 2000
  6. ncbi A comparison of two antimicrobial-impregnated central venous catheters. Catheter Study Group
    R O Darouiche
    Department of Medicine, Baylor College of Medicine and Veterans Affairs Medical Center, Houston, TX 77030, USA
    N Engl J Med 340:1-8. 1999
  7. ncbi Biocompatibility index of antiseptic agents by parallel assessment of antimicrobial activity and cellular cytotoxicity
    Gerald Müller
    Institute of Hygiene and Environmental Medicine, University of Greifswald, W Rathenau Str 49a, D 17487 Greifswald, Germany
    J Antimicrob Chemother 61:1281-7. 2008
  8. ncbi Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump
    Edward W Yu
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3202, USA
    Science 300:976-80. 2003
  9. ncbi Hand-rubbing with an aqueous alcoholic solution vs traditional surgical hand-scrubbing and 30-day surgical site infection rates: a randomized equivalence study
    Jean Jacques Parienti
    Departments of Infectious Diseases and Intensive Care Unit, Côte de Nacre University Hospital Centre, 14 033 Caen Cedex, France
    JAMA 288:722-7. 2002
  10. ncbi Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products
    Mats Allmyr
    Institute of Odontology, Karolinska Institutet, PO Box 4064, SE 141 04 Huddinge, Sweden
    Sci Total Environ 372:87-93. 2006

Detail Information

Publications253 found, 100 shown here

  1. ncbi Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Infection Control Programme
    D Pittet
    Department of Internal Medicine, University of Geneva Hospitals, and Institute of Social and Preventive Medicine, University of Geneva, Switzerland
    Lancet 356:1307-12. 2000
    ..We attempted to promote hand hygiene by implementing a hospital-wide programme, with special emphasis on bedside, alcohol-based hand disinfection. We measured nosocomial infections in parallel...
  2. ncbi Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America/Association for Prof
    John M Boyce
    Hospital of Saint Raphael, New Haven, Connecticut, USA
    MMWR Recomm Rep 51:1-45, quiz CE1-4. 2002
    ..Recommendations concerning related issues (e.g., the use of surgical hand antiseptics, hand lotions or creams, and wearing of artificial fingernails) are also included...
  3. pmc Epidemiologic background of hand hygiene and evaluation of the most important agents for scrubs and rubs
    Gunter Kampf
    Bode Chemie GmbH and Co, Scientific Affairs, Melanchthonstrasse 27, 22525 Hamburg, Germany
    Clin Microbiol Rev 17:863-93, table of contents. 2004
    ....
  4. ncbi Consumer antibacterial soaps: effective or just risky?
    Allison E Aiello
    Department of Epidemiology and Center for Social Epidemiology and Population Health, University of Michigan, Ann Arbor, Ann Arbor, MI 48104 2548, USA
    Clin Infect Dis 45:S137-47. 2007
    ....
  5. ncbi Triclosan: a review of effectiveness and safety in health care settings
    R D Jones
    Scientific and Regulatory Consultants, Inc, Columbia City, IN 46725, USA
    Am J Infect Control 28:184-96. 2000
    ..This review highlights the utility and effectiveness of a 1% triclosan formulation for use in high-risk, high-frequency handwashing...
  6. ncbi A comparison of two antimicrobial-impregnated central venous catheters. Catheter Study Group
    R O Darouiche
    Department of Medicine, Baylor College of Medicine and Veterans Affairs Medical Center, Houston, TX 77030, USA
    N Engl J Med 340:1-8. 1999
    ..We compared the rates of catheter colonization and catheter-related bloodstream infection associated with these two kinds of antiinfective catheters...
  7. ncbi Biocompatibility index of antiseptic agents by parallel assessment of antimicrobial activity and cellular cytotoxicity
    Gerald Müller
    Institute of Hygiene and Environmental Medicine, University of Greifswald, W Rathenau Str 49a, D 17487 Greifswald, Germany
    J Antimicrob Chemother 61:1281-7. 2008
    ..To assess the suitability of an antiseptic agent, both the microbicidal activity and the cytotoxic effect must be taken into consideration to derive biocompatible antibacterial agents...
  8. ncbi Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump
    Edward W Yu
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3202, USA
    Science 300:976-80. 2003
    ..Each ligand uses a slightly different subset of AcrB residues for binding. The bound ligand molecules often interact with each other, stabilizing the binding...
  9. ncbi Hand-rubbing with an aqueous alcoholic solution vs traditional surgical hand-scrubbing and 30-day surgical site infection rates: a randomized equivalence study
    Jean Jacques Parienti
    Departments of Infectious Diseases and Intensive Care Unit, Côte de Nacre University Hospital Centre, 14 033 Caen Cedex, France
    JAMA 288:722-7. 2002
    ..Clinical studies comparing the risk of nosocomial infection after different hand antisepsis protocols are scarce...
  10. ncbi Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products
    Mats Allmyr
    Institute of Odontology, Karolinska Institutet, PO Box 4064, SE 141 04 Huddinge, Sweden
    Sci Total Environ 372:87-93. 2006
    ..The concentrations were significantly higher in plasma than in milk, indicating that infant exposure to triclosan via breast milk is much less than the dose in the mother...
  11. ncbi In vitro evaluation of the risk of developing bacterial resistance to antiseptics and antibiotics used in medical devices
    S M Tambe
    Department of Surgery, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, BB 1734, New York, NY 10032, USA
    J Antimicrob Chemother 47:589-98. 2001
    ..Although this study indicates that antibiotic catheters may be at a higher risk of being colonized by antibiotic-resistant bacteria, the implications of these results in clinical settings need to be determined...
  12. ncbi High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux
    Rungtip Chuanchuen
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, USA
    Am J Infect Control 31:124-7. 2003
    ..Pseudomonas aeruginosa is intrinsically resistant to high levels of triclosan...
  13. pmc Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide
    A Robert Neurath
    Biochemical Virology Laboratory, Lindsley F, Kimball Research Institute, New York Blood Center, New York, USA
    BMC Infect Dis 4:41. 2004
    ..Already marketed pharmaceutical excipients or foods, with established safety records and adequate anti-HIV-1 activity, may provide this option...
  14. pmc Liquid versus gel handrub formulation: a prospective intervention study
    Ousmane Traore
    Infection Control Programme, University of Geneva Hospitals, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Crit Care 11:R52. 2007
    ..Alcohol-based handrub is the new standard for hand hygiene action worldwide and usually requires a system change for its successful introduction in routine care. Product acceptability by HCWs is a crucial step in this process...
  15. ncbi Triclosan: applications and safety
    H N Bhargava
    Division of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Allied Health Sciences, Boston 02115, USA
    Am J Infect Control 24:209-18. 1996
    ..A new application for triclosan is in oral dentifrices for plaque control. Currently under investigation in the United States, it is approved for oral care application in Canada and many European countries...
  16. ncbi Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives
    R N Fichorova
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Reprod 71:761-9. 2004
    ..The described evaluation system is a valuable tool in identifying novel vaginal contraceptive microbicides, selecting out candidates that may enhance, rather than decrease, HIV transmission...
  17. ncbi In vitro antiseptic susceptibility of clinical isolates from nosocomial infections
    M Shimizu
    Pharmaceutical Research Center, Meiji Seika Kaisha Ltd, Yokohama, Japan
    Dermatology 204:21-7. 2002
    ..Among the 4 antiseptics tested, PVP-I and BAC showed a consistently high activity against all isolates, confirming PVP-I and BAC to be clinically useful antiseptics...
  18. ncbi Microbicides--aids to safer sex
    Robin Shattock
    St George s Hospital Medical School, London SW17 ORE, UK
    Lancet 363:1002-3. 2004
  19. ncbi Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis
    Nathorn Chaiyakunapruk
    Department of Pharmacy Practice, School of Pharmacy, Naresuan University, Pitsanuloak 65000, Thailand
    Ann Intern Med 136:792-801. 2002
    ..This study evaluated the efficacy of skin disinfection with chlorhexidine gluconate compared with povidone-iodine solution in preventing catheter-related bloodstream infection...
  20. ncbi Introducing alcohol-based hand rub for hand hygiene: the critical need for training
    Andreas F Widmer
    Division of Infection Control and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    Infect Control Hosp Epidemiol 28:50-4. 2007
    ..However, the proper technique for using hand rub has not been well described and is not routinely taught in hospitals...
  21. pmc Relationship between triclosan and susceptibilities of bacteria isolated from hands in the community
    Allison E Aiello
    Center for Social Epidemiology and Public Health, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104 2548, USA
    Antimicrob Agents Chemother 48:2973-9. 2004
    ..Still, a relationship may emerge after longer-term or higher-dose exposure of bacteria to triclosan in the community setting...
  22. ncbi Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-center, double-blind placebo-controlled study
    E G Winkel
    Clinic for Periodontology Amsterdam, de Boelelaan 589, 1082 RM Amsterdam, The Netherlands
    J Clin Periodontol 30:300-6. 2003
    ..The aim of this double-blind, parallel study was to test the clinical efficacy of a newly developed mouthrinse in the treatment of oral halitosis in patients without periodontitis...
  23. ncbi Pharmacokinetics of triclosan following oral ingestion in humans
    Gunilla Sandborgh-Englund
    Institute of Odontology, Karolinska Institutet, Huddinge, Sweden
    J Toxicol Environ Health A 69:1861-73. 2006
    ..The findings of the present study form a basis for greater understanding of the toxicokinetic properties of triclosan in humans...
  24. ncbi Effect of two new chlorhexidine mouthrinses on the development of dental plaque, gingivitis, and discolouration. A randomized, investigator-blind, placebo-controlled, 3-week experimental gingivitis study
    K Lorenz
    Department of Conservative Dentistry Medical Faculty, Dresden University of Technology, Dresden, Germany
    J Clin Periodontol 33:561-7. 2006
    ..The aim of this experimental gingivitis study was to assess the efficacy and safety of two new chlorhexidine (CHX) mouthrinses...
  25. ncbi Chlorhexidine substantivity in root canal dentin
    Sidney Rosenthal
    Department of Endodontology, University of Connecticut School of Dental Medicine, Farmington, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:488-92. 2004
    ..The purpose of this investigation was to evaluate the substantivity of chlorhexidine (CHX) within a root canal system and to assess how long the CHX remains antimicrobially effective...
  26. pmc Reduced triclosan susceptibility in methicillin-resistant Staphylococcus epidermidis
    Molly B Schmid
    Affinium Pharmaceuticals, Inc, Toronto, Ontario M5J 1V6, Canada
    Antimicrob Agents Chemother 48:1397-9. 2004
    ..12 microg/ml and a MIC(90) of 8 microg/ml. Decreased susceptibility to triclosan was more prevalent among methicillin-resistant S. epidermidis than among methicillin-sensitive S. epidermidis isolates...
  27. ncbi Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5
    Michael M Lederman
    Department of Medicine, Case Western Reserve University, University Hospitals, 2061 Cornell Road, Cleveland, OH 44106, USA
    Science 306:485-7. 2004
    ..These experimental findings have potentially important implications for understanding vaginal transmission of HIV and the design of strategies for its prevention...
  28. ncbi Triclosan, a commonly used bactericide found in human milk and in the aquatic environment in Sweden
    Margaretha Adolfsson-Erici
    Institute of Applied Environmental Research, Stockholm University, Sweden
    Chemosphere 46:1485-9. 2002
    ..It was also found in the bile of fish exposed to municipal wastewater and in wild living fish from the receiving waters of the three wastewater treatment plants...
  29. ncbi Hand hygiene with soap and water is superior to alcohol rub and antiseptic wipes for removal of Clostridium difficile
    Matthew T Oughton
    Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Infect Control Hosp Epidemiol 30:939-44. 2009
    ..To evaluate common hand hygiene methods for efficacy in removing Clostridium difficile...
  30. ncbi Rectal applications of nonoxynol-9 cause tissue disruption in a monkey model
    Dorothy L Patton
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Sex Transm Dis 29:581-7. 2002
    ..Efforts to develop topical microbicide products have all but ignored evaluation for rectal use...
  31. pmc Eradication of resident bacteria of normal human skin by antimicrobial ointment
    J Owen Hendley
    Department of Pediatrics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Antimicrob Agents Chemother 47:1988-90. 2003
    ..Through 15 layers, mupirocin had some effect, whereas a double-antibiotic ointment had none. The reservoir of resident bacteria in the sebaceous glands is not affected by a topical antibiotic...
  32. pmc Comparative safety evaluation of the candidate vaginal microbicide C31G
    Bradley J Catalone
    Department of Microbiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Antimicrob Agents Chemother 49:1509-20. 2005
    ..The Swiss Webster animal model may be a highly valuable tool for preclinical evaluation of candidate vaginal microbicides...
  33. ncbi Is skin disinfection with 10% povidone iodine sufficient to prevent epidural needle and catheter contamination?
    E Alp Yentur
    Celal Bayar University, School of Medicine, Manisa, Turkey
    Reg Anesth Pain Med 28:389-93. 2003
    ..Epidural space infection is a potential complication of epidural catheter placement. In this study, we investigated the incidence of epidural needle and catheter contamination after skin surface disinfection with 10% povidone-iodine (PI)...
  34. ncbi In vitro study on the influence of N-chlorotaurine on the ciliary beat frequency of nasal mucosa
    Edmund Hofer
    Department of Otorhinolaryngology, University Hospital of Innsbruck, Austria
    Am J Rhinol 17:149-52. 2003
    ..The aim of this study was to investigate the in vitro effects of N-chlorotaurine (NCT), a new endogenous antimicrobial agent, on the nasal ciliary beat frequency (CBF) in nasal mucosa samples of 10 adult patients who underwent conchotomy...
  35. ncbi Silver-coated dressing acticoat caused raised liver enzymes and argyria-like symptoms in burn patient
    Marija Trop
    Department of Paediatrics, Children s Burns Unit, and the Institute of Chemistry, Analytical Chemistry, Medical University of Graz, Graz, Austria
    J Trauma 60:648-52. 2006
    ..Numerous adverse reactions and side effects have been reported and an increasing resistance to SSD, especially in Pseudomonas strains, have motivated researchers to search for an alternative wound dressing...
  36. ncbi Hand hygiene rates unaffected by installation of dispensers of a rapidly acting hand antiseptic
    C A Muto
    University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Infect Control 28:273-6. 2000
    ..Compliance with handwashing after half of all patient contacts was a result of perfect compliance by some and total noncompliance by others being observed...
  37. ncbi Antibacterial cleaning and hygiene products as an emerging risk factor for antibiotic resistance in the community
    Allison E Aiello
    Department of Epidemiology, Joseph Mailman School of Public Health, Columbia University, New York 10032, USA
    Lancet Infect Dis 3:501-6. 2003
    ....
  38. ncbi A review of the toxicity of Melaleuca alternifolia (tea tree) oil
    K A Hammer
    Microbiology and Immunology M502, School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, WA 6009, Australia
    Food Chem Toxicol 44:616-25. 2006
    ..The limited ecotoxicity data available indicate that TTO is toxic to some insect species but more studies are required...
  39. ncbi Guidelines for the prevention of intravascular catheter-related infections. Centers for Disease Control and Prevention
    NAOMI P O'GRADY
    National Institutes of Health, Bethesda, Maryland, USA
    MMWR Recomm Rep 51:1-29. 2002
    ..These guidelines also identify performance indicators that can be used locally by health-care institutions or organizations to monitor their success in implementing these evidence-based recommendations...
  40. pmc In vitro comparison of topical microbicides for prevention of human immunodeficiency virus type 1 transmission
    Charlene S Dezzutti
    Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Mailstop G19, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 48:3834-44. 2004
    ..Moreover, our systematic anti-HIV-1 testing provides a rational basis for making better informed decisions about which products to consider for clinical trials...
  41. pmc Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis
    Ee Yuee Chan
    Department of Nursing Services, Tan Tock Seng Hospital, Singapore
    BMJ 334:889. 2007
    ..To evaluate the effect of oral decontamination on the incidence of ventilator associated pneumonia and mortality in mechanically ventilated adults...
  42. ncbi Antimicrobials in future caries control? A review with special reference to chlorhexidine treatment
    Svante Twetman
    Department of Odontology, Pediatric Dentistry, Umea University, Umea, Sweden
    Caries Res 38:223-9. 2004
    ..In conclusion, the evidence from the recent literature was inconclusive for the use of CHX varnishes for caries prevention in risk groups...
  43. ncbi Chlorhexidine-impregnated sponges and less frequent dressing changes for prevention of catheter-related infections in critically ill adults: a randomized controlled trial
    Jean Francois Timsit
    INSERM U823, University Joseph Fourier, Albert Boniot Institute, 38076, Grenoble Cedex, France
    JAMA 301:1231-41. 2009
    ..Use of a chlorhexidine gluconate-impregnated sponge (CHGIS) in intravascular catheter dressings may reduce catheter-related infections (CRIs). Changing catheter dressings every 3 days may be more frequent than necessary...
  44. ncbi Triclosan: a widely used biocide and its link to antibiotics
    H P Schweizer
    Department of Microbiology, Colorado State University, Fort Collins, CO 80523 1677, USA
    FEMS Microbiol Lett 202:1-7. 2001
    ....
  45. ncbi Prevention of irritant contact dermatitis among health care workers by using evidence-based hand hygiene practices: a review
    Gunter Kampf
    BODE Chemie GmbH and Co KG, Scientific Affairs, Hamburg, Germany
    Ind Health 45:645-52. 2007
    ..Adhering to evidence-based hand hygiene protocols and following international guidelines on hand hygiene practices therefore, can help prevent irritant contact dermatitis among healthcare workers...
  46. pmc Antibacterial household products: cause for concern
    S B Levy
    Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Emerg Infect Dis 7:512-5. 2001
    ..As with antibiotics, prudent use of these products is urged. Their designated purpose is to protect vulnerable patients...
  47. ncbi Comparative testing of liposomal and aqueous formulations of povidone-iodine for their angioirritative potential at the chorioallantoic membrane of ex ovo cultivated chick embryos
    P Wutzler
    Institute for Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
    Dermatology 207:43-7. 2003
    ..Previous studies have shown that liposomal PVP-I formulations are less cytotoxic and that a special liposomal PVP-I hydrogel provides wound healing efficacy...
  48. ncbi The impact of topical antiseptics on skin microcirculation
    S Langer
    Department of Plastic and Hand Surgery, Burn Center, BG University Hospital, Ruhr Universitat Bochum, Buerkle de la Camp Platz 1, D 44789 Bochum, Germany
    Eur J Med Res 9:449-54. 2004
    ..However, topical antiseptics are assumed to have an influence on skin microcirculation, per se. Thus, the aim of the study was to analyse the influence of topically applied antiseptics on the microcirculation of intact skin in vivo...
  49. ncbi Short- and long-term effects of handwashing with antimicrobial or plain soap in the community
    Elaine Larson
    Schools of Nursing and Public Health, Columbia University, New York, NY 10032, USA
    J Community Health 28:139-50. 2003
    ..In the absence of more definitive evidence, the risk-benefit ratio argues in favor of targeted rather than ubiquitous, general household use of antimicrobial soap...
  50. ncbi The antimicrobial effect of acetic acid--an alternative to common local antiseptics?
    H Ryssel
    Department of Hand, Plastic and Reconstructive Surgery and Burn Center, BG Trauma Center Ludwigshafen, Ludwigshafen, Germany
    Burns 35:695-700. 2009
    ..It can be concluded that acetic acid in a concentration of 3% has excellent bactericidal effect and, therefore, seems to be suitable as a local antiseptic agent, but further clinical studies are necessary...
  51. ncbi [Tissue toxicity of antiseptics]
    T Kalteis
    Orthopädische Universitätsklinik Regensburg
    Z Orthop Ihre Grenzgeb 141:233-8. 2003
    ..The aim of this study was to determine the tissue toxicity of different antiseptics and to measure the irritation score (IS) and the irritation threshold (IT) for each substance...
  52. ncbi Tolerability and efficacy of N-chlorotaurine in comparison with chloramine T for the treatment of chronic leg ulcers with a purulent coating: a randomized phase II study
    M Nagl
    Institute of Hygiene and Social Medicine, Leopold Franzens University of Innsbruck, Fritz Pregl Str 3, A 6010 Innsbruck, Austria
    Br J Dermatol 149:590-7. 2003
    ..The tolerability of the less aggressive N-chlorotaurine (NCT), an endogenous compound also produced in vivo by stimulated human granulocytes, could be superior...
  53. pmc Mechanism of action of Melaleuca alternifolia (tea tree) oil on Staphylococcus aureus determined by time-kill, lysis, leakage, and salt tolerance assays and electron microscopy
    Christine F Carson
    Department of Microbiology, The University of Western Australia, Crawley
    Antimicrob Agents Chemother 46:1914-20. 2002
    ....
  54. pmc Antiseptic technology: access, affordability, and acceptance
    J M Boyce
    Hospital of St Raphael, New Haven, Connecticut, USA
    Emerg Infect Dis 7:231-3. 2001
    ....
  55. ncbi Effect of different mouthrinses on morning breath
    D van Steenberghe
    Department of Periodontology, Oral Pathology and Maxillo-Facial Surgery, Faculty of Medicine, Catholic University of Leuven, Belgium
    J Periodontol 72:1183-91. 2001
    ..CHX-Alc and CHX-CPC-Zn mouthrinses result in a significant reduction of the microbial load of tongue and saliva...
  56. ncbi Phase 1 trial of the topical microbicide BufferGel: safety results from four international sites
    J van De Wijgert
    University of Zimbabwe University of California San Francisco Women s Health Program, Harare, Zimbabwe
    J Acquir Immune Defic Syndr 26:21-7. 2001
    ..To evaluate the safety of BufferGel (ReProtect LLC, Baltimore, MD), a spermicidal microbicide that acidifies semen and maintains the protective acidity of the vagina, in a high-dose tolerance trial...
  57. ncbi Chlorhexidine concentration in saliva after topical treatment with an antibacterial dental varnish
    Eugenio Brambilla
    Department of Pediatric Dentistry, University of Milan, School of Dentistry, Italy
    Am J Dent 17:196-8. 2004
    ..To evaluate the salivary levels of chlorhexidine (CHX) after a single professional treatment with an antibacterial dental varnish (Cervitec) containing 1% CHX and 1% thymol...
  58. ncbi Effectiveness of chlorhexidine-thymol varnish in preventing caries lesions in primary molars
    Pilar Baca
    Department of Preventive Dentistry, School of Dentistry, University of Granada, Granada, Spain
    J Dent Child (Chic) 71:61-5. 2004
    ..The objective of this study was to evaluate the effect of chlorhexidine-thymol varnish on the prevention of caries lesions in primary molars among schoolchildren ages 6 to 7 in relation to their previous experience with caries...
  59. pmc Influence of applied volume on efficacy of 3-minute surgical reference disinfection method prEN 12791
    Gunter Kampf
    Scientific Affairs, BODE Chemie GmbH, Hamburg, Germany
    Appl Environ Microbiol 70:7066-9. 2004
    ..689]; for sustained effect, Pearson's correlation coefficient = 0.059 [P = 0.404]). If the hands were kept wet with the reference alcohol for the total application time, the applied volume could vary, but this did not alter the efficacy...
  60. ncbi Assessment of the antibacterial activity of tea tree oil using the European EN 1276 and EN 12054 standard suspension tests
    S Messager
    Discipline of Microbiology, School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley WA 6009, Australia
    J Hosp Infect 59:113-25. 2005
    ..The formulations used in this study are now being tested using a novel ex vivo method as well as the in vivo European standard handwashing method EN 1499...
  61. ncbi Surgical hand disinfection with a propanol-based hand rub: equivalence of shorter application times
    G Kampf
    Bode Chemie GmbH and Co, Scientific Affairs, Melanchthonstr 27, 22525 Hamburg, Germany
    J Hosp Infect 59:304-10. 2005
    ..Using 2 x 3 mL Sterillium for a total of 1.5 min for surgical hand disinfection was at least as effective as the 3-min reference disinfection...
  62. ncbi SPL7013 gel as a topical microbicide for prevention of vaginal transmission of SHIV89.6P in macaques
    Yong Hou Jiang
    Washington National Primate Research Center, University of Washington, Seattle, Washington 98195, USA
    AIDS Res Hum Retroviruses 21:207-13. 2005
    ..These results suggest that SPL7013 gel may be a promising anti-HIV microbicide formulation for further evaluation...
  63. ncbi Inhibition of Porphyromonas gingivalis proteinases (gingipains) by chlorhexidine: synergistic effect of Zn(II)
    C A Cronan
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602 7229, USA
    Oral Microbiol Immunol 21:212-7. 2006
    ..The purposes of the present study were to examine systematically the inhibitory effects of chlorhexidine on three purified gingipains and to determine the effect of Zn(II) on chlorhexidine inhibition...
  64. ncbi Does the clinical use of ethanol-based hand sanitizer elevate blood alcohol levels? A prospective study
    Michael A Miller
    Department of Emergency Medicine, C R Darnall Army Medical Center, Hood, TX 76544, USA
    Am J Emerg Med 24:815-7. 2006
    ..To investigate the effect of frequent use of EBHS upon serum blood ethanol concentrations, we prospectively studied 5 volunteers undergoing frequent application of EBHS...
  65. ncbi Prevention of nosocomial infection in cardiac surgery by decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate: a randomized controlled trial
    Patrique Segers
    Department of Cardiothoracic Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    JAMA 296:2460-6. 2006
    ..Nosocomial infections are an important cause of morbidity and mortality after cardiac surgery. Decolonization of endogenous potential pathogenic microorganisms is important in the prevention of nosocomial infections...
  66. ncbi Prospective randomized trial of 3 antiseptic solutions for prevention of catheter colonization in an intensive care unit for adult patients
    J Valles
    Critical Care Center, Hospital Sabadell, Institut Universitari Parc Tauli, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Sabadell, Spain
    Infect Control Hosp Epidemiol 29:847-53. 2008
    ..5% alcoholic chlorhexidine gluconate (alcoholic CG)...
  67. ncbi Skin reactions related to hand hygiene and selection of hand hygiene products
    Elaine Larson
    School of Nursing, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Infect Control 34:627-35. 2006
    ..quot; As a result, the WHO is developing Guidelines on Hand Hygiene in Health Care, designed to be applicable throughout the world...
  68. ncbi Topical chlorhexidine for prevention of ventilator-associated pneumonia: a meta-analysis
    Maciej Piotr Chlebicki
    Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
    Crit Care Med 35:595-602. 2007
    ..To assess the efficacy of topical chlorhexidine for prevention of ventilator-associated pneumonia (VAP) in a meta-analysis...
  69. ncbi Randomized controlled trial and meta-analysis of oral decontamination with 2% chlorhexidine solution for the prevention of ventilator-associated pneumonia
    Hutsaya Tantipong
    Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Infect Control Hosp Epidemiol 29:131-6. 2008
    ..To determine the effectiveness of oral decontamination with 2% chlorhexidine solution for the prevention of ventilator-associated pneumonia (VAP)...
  70. ncbi Tolerability of N-chlorotaurine plus ammonium chloride in the rabbit and human eye--a phase 1 clinical study
    Barbara Teuchner
    Department of Ophthalmology, Innsbruck Medical University, Innsbruck, Austria
    Graefes Arch Clin Exp Ophthalmol 246:1723-30. 2008
    ..The aim of this study was to evaluate the tolerability of NCT plus ammonium chloride in the healthy rabbit and human eye...
  71. ncbi Chlorhexidine-containing chewing gum. Clinical documentation
    Thomas Imfeld
    Klinik für Präventivzahnmedizin, Parodontologie und Kariologie, Zentrum fur Zahn, Mund und Kieferheilkunde, Universitat Zurich
    Schweiz Monatsschr Zahnmed 116:476-83. 2006
    ..Indication, dosage, precautions and benefits of CHX chewing gum are described...
  72. ncbi Microbicides and other topical strategies to prevent vaginal transmission of HIV
    Michael M Lederman
    Case Western Reserve University, 2061 Cornell Road, Cleveland, Ohio, USA
    Nat Rev Immunol 6:371-82. 2006
    ..We discuss the targets for topical agents that have been identified by studies of the biology of HIV infection and provide an overview of the progress towards the development of a usable agent...
  73. ncbi Co-occurrence of triclocarban and triclosan in U.S. water resources
    Rolf U Halden
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205 2103, USA
    Environ Sci Technol 39:1420-6. 2005
    ..S.) currently used by the U.S. Environmental Protection Agency for evaluating TCC's ecological and human health risks...
  74. ncbi Effect of gingival and dental plaque antiseptic decontamination on nosocomial infections acquired in the intensive care unit: a double-blind placebo-controlled multicenter study
    Francois Fourrier
    Department of Intensive Care, Hopital Roger Salengro, Universite de Lille II, France
    Crit Care Med 33:1728-35. 2005
    ..To document the effect of gingival and dental plaque antiseptic decontamination on the rate of nosocomial bacteremias and respiratory infections acquired in the intensive care unit (ICU)...
  75. ncbi A randomized, controlled trial of a multifaceted intervention including alcohol-based hand sanitizer and hand-hygiene education to reduce illness transmission in the home
    Thomas J Sandora
    Division of Infectious Diseases, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Pediatrics 116:587-94. 2005
    ..The objective of this study was to determine whether a multifactorial campaign centered on increasing alcohol-based hand sanitizer use and hand-hygiene education reduces illness transmission in the home...
  76. ncbi Comparison of silver-coated dressing (Acticoat), chlorhexidine acetate 0.5% (Bactigrass), and silver sulfadiazine 1% (Silverdin) for topical antibacterial effect in Pseudomonas aeruginosa-contaminated, full-skin thickness burn wounds in rats
    Ersin Ulkur
    GATA Haydarpasa Training Hospital, Istanbul, Turkey
    J Burn Care Rehabil 26:430-3. 2005
    ..aeruginosa-contaminated burn wounds; Acticoat can be considered as a treatment choice because of its peculiar ability of limiting the frequency of replacing wound dressings...
  77. ncbi Chlorhexidine-containing glass ionomer cement. A clinical investigation on the fissure caries inhibiting effect in first permanent molars
    Anders Hoszek
    Department of Cariology, Faculty of Odontology, Malmo University, Sweden
    Swed Dent J 29:89-96. 2005
    ..Excluding the sealed molars the reduction was 74% in the GI-CHX-group, and 71% in the GI-group...
  78. ncbi Short-term side effects of 0.2% alcohol-free chlorhexidine mouthrinse used as an adjunct to non-surgical periodontal treatment: a double-blind clinical study
    Cem A Gurgan
    Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey
    J Periodontol 77:370-84. 2006
    ..2% chlorhexidine (CHX) mouthrinse without alcohol used as an adjunct to non-surgical periodontal treatment and to elucidate the relationship between the subjective and objective evaluations...
  79. ncbi Effect of a controlled-release chlorhexidine chip on clinical and microbiological parameters and prostaglandin E2 levels in gingival crevicular fluid
    Tansel Mizrak
    Department of Periodontology, Faculty of Dentistry, Dicle University, Diyarbakir, Turkey
    J Periodontol 77:437-43. 2006
    ....
  80. ncbi Oral decontamination with chlorhexidine reduces the incidence of ventilator-associated pneumonia
    Mirelle Koeman
    University Medical Center Utrecht, Department of Internal Medicine and Dermatology, and Department of Internal Medicine and Intensive Care Medicine, Rijnstate Hospital Arnhem, The Netherlands
    Am J Respir Crit Care Med 173:1348-55. 2006
    ..We hypothesized that oral decontamination with either chlorhexidine (CHX, 2%) or CHX/colistin (CHX/COL, 2%/2%) would reduce and postpone development of VAP, and oral and endotracheal colonization...
  81. ncbi Topical applications of ozone and ozonated oils as anti-infective agents: an insight into the patent claims
    Valter Travagli
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Italy
    Recent Pat Antiinfect Drug Discov 4:130-42. 2009
    ....
  82. ncbi Chlorhexidine varnishes: a review
    S Matthijs
    Free University of Brussels, School of Dental Medicine, Department of Periodontology, Laarbeeklaan 103, B 1090 Brussels, Belgium
    J Clin Periodontol 29:1-8. 2002
    ..During the past decade, varnishes for local delivery of antimicrobial agents have been developed and investigated in vitro and in vivo...
  83. ncbi Effects of topical chlorhexidine applied to the rabbit nasal mucosa
    Hakan Cankaya
    Department of Otorhinolaryngology, Medical Faculty Yüzüncü Yil University, 65200 Van, Turkey
    Auris Nasus Larynx 30:65-9. 2003
    ..To search the effects of administration of various concentrations of a wide-spectrum antimicrobial agent, chlorhexidine, to the nasal mucosa...
  84. ncbi Evidence for the microbicidal activity of a chlorine dioxide-containing oral rinse formulation in vivo
    M Grootveld
    St Bartholomew s and the Royal London School of Medicine and Dentistry, London, United Kingdom
    J Clin Dent 12:67-70. 2001
    ..The therapeutic, microbial and biochemical ramifications of the results obtained are discussed...
  85. ncbi Prophylactic chlorhexidine oral rinse decreases ventilator-associated pneumonia in surgical ICU patients
    T Genuit
    VA Maryland Health Care System and University of Maryland School of Medicine, Baltimore, Maryland, USA
    Surg Infect (Larchmt) 2:5-18. 2001
    ..The purpose of this study was to determine whether adherence to a ventilator weaning protocol (WP) and the use of chlorhexidine gluconate (CH) oral rinse for oral hygiene would decrease the incidence of VAP in surgical ICU patients...
  86. ncbi Arguments for alcoholic hand disinfection
    M L Rotter
    Hygiene Institute of the University, Kinderspitalgasse, Vienna, Austria
    J Hosp Infect 48:S4-8. 2001
    ..The mode of their application is simple and three to four times more economical of time than wash procedures, features which help to increase the compliance with the rules of hand hygiene...
  87. ncbi Triclosan: occurrence and fate of a widely used biocide in the aquatic environment: field measurements in wastewater treatment plants, surface waters, and lake sediments
    Heinz Singer
    Swiss Federal Institute for Environmental Science and Technology EAWAG, Uberlandstrasse 133, CH 8600 Dübendorf Switzerland
    Environ Sci Technol 36:4998-5004. 2002
    ..As the measured concentrations in surface waters are in the range of the predicted no effect concentration of 50 ng/L, more measurements and a detailed investigation of the degradation processes are needed...
  88. ncbi The efficacy of amine fluoride/stannous fluoride in the suppression of morning breath odour
    Marc Quirynen
    Department of Periodontology, School of Dentistry, Oral Pathology and Maxillo Facial Surgery, Faculty of Medicine, Catholic University of Leuven, Heverlee, Belgium
    J Clin Periodontol 29:944-54. 2002
    ..a control solution in the prevention of morning bad breath during an experimental period of 7 days without mechanical plaque control...
  89. ncbi Effect of Cervitec on mutans streptococci in plaque and on caries formation on occlusal fissures of erupting permanent molars
    A M P G Araujo
    Department of Pediatric Dentistry, Institute of Health Sciences, Paulista University, Brazil
    Caries Res 36:373-6. 2002
    ..In conclusion, our results suggest that treatment with Cervitec reduces MS in plaque on erupting permanent molars and can lead to a significant decrease in caries incidence...
  90. ncbi Anaphylactic reactions in anaesthetised patients - four cases of chlorhexidine allergy
    L H Garvey
    Department of Anaesthesiology, Gentofte University Hospital, Copenhagen, Denmark
    Acta Anaesthesiol Scand 45:1290-4. 2001
    ..Allergy to chlorhexidine may be more prevalent in surgical patients and cases may have been overlooked due to the nature of reactions and lack of suspicion towards this substance...
  91. ncbi Effectiveness of chlorhexidine-thymol varnish for caries reduction in permanent first molars of 6-7-year-old children: 24-month clinical trial
    Pilar Baca
    Department of Preventive Dentistry, School of Dentistry, University of Granada, Granada, Spain
    Community Dent Oral Epidemiol 30:363-8. 2002
    ..To determine the effect of chlorhexidine varnish on the prevention of caries in permanent first molars...
  92. ncbi A clinical study comparing the skin antisepsis and safety of ChloraPrep, 70% isopropyl alcohol, and 2% aqueous chlorhexidine
    John S Hibbard
    Mediflex Hospital Products Inc, 8717 West 110th Street, Suite 750, Overland Park, KS 66210, USA
    J Infus Nurs 25:244-9. 2002
    ..0001). CHG + IPA provided significantly more persistent antimicrobial activity on abdominal sites than IPA (P =.003) or CHG (P =.028) at 24 hours. No skin irritations were reported for any of the three antiseptics...
  93. ncbi Methods for evaluating changes in skin condition due to the effects of antimicrobial hand cleansers: two studies comparing a new waterless chlorhexidine gluconate/ethanol-emollient antiseptic preparation with a conventional water-applied product
    G L Grove
    KGL Skin Study Center, Broomall, Pennsylvania, USA
    Am J Infect Control 29:361-9. 2001
    ..007). CONCLUSIONS: All 3 approaches of expert grader evaluation, subject assessment, and instrumentation were in concordance, demonstrating that the waterless CHG/ethanol product was gentler to skin than the conventional CHG product...
  94. ncbi Measurement of triclosan in wastewater treatment systems
    Drew C McAvoy
    The Procter and Gamble Company, Miami Valley Laboratory, Cincinnati, OH 45253 8707, USA
    Environ Toxicol Chem 21:1323-9. 2002
    ..Based on results from this study, the chlorinated analogues and biotransformation by-product of TCS are expected to be very low in receiving waters and sludge-amended soils...
  95. ncbi Comparison of waterless hand antisepsis agents at short application times: raising the flag of concern
    Sasi Dharan
    Infection Control Program, Department of Internal Medicine, University of Geneva Hospitals, Geneva, Switzerland
    Infect Control Hosp Epidemiol 24:160-4. 2003
    ....
  96. ncbi Efficacy of antiseptic-impregnated central venous catheters in preventing catheter-related bloodstream infection: a meta-analysis
    D L Veenstra
    Department of Pharmacy, University of Washington, Seattle, USA
    JAMA 281:261-7. 1999
    ..However, there remains some uncertainty regarding the efficacy of these catheters because of conflicting reports in the literature...
  97. ncbi Wound irrigation in musculoskeletal injury
    J O Anglen
    Orthopaedic Surgery, University of Missouri-Columbia, Columbia 65212, USA
    J Am Acad Orthop Surg 9:219-26. 2001
    ..There are few animal or clinical studies of musculoskeletal wounds. Detergent irrigation aims to remove, rather than kill, bacteria and has shown promise in animal models of the complex contaminated musculoskeletal wound...
  98. pmc Improving adherence to hand hygiene practice: a multidisciplinary approach
    D Pittet
    University of Geneva Hospitals, Geneva, Switzerland
    Emerg Infect Dis 7:234-40. 2001
    ..This article reviews barriers to appropriate hand hygiene and risk factors for noncompliance and proposes strategies for promoting hand hygiene...
  99. ncbi Development of resistance to chlorhexidine diacetate in Pseudomonas aeruginosa and the effect of a "residual" concentration
    L Thomas
    Pharmaceutical Microbiology Research, Welsh School of Pharmacy, Cardiff University, Cardiff, CF10 3XF, UK
    J Hosp Infect 46:297-303. 2000
    ..Antibiotic susceptibility profiles of the CHX-resistant P. aeruginosa cultures showed no cross-resistance, although some of the cultures were resistant to benzalkonium chloride...
  100. ncbi Marvellous microbicides. Intravaginal gels could save millions of lives, but first someone has to prove that they work
    Hannah Brown
    Lancet 363:1042-3. 2004
  101. ncbi Clinical and microbiological efficacy of chlorine dioxide in the management of chronic atrophic candidiasis: an open study
    Abdel R Mohammad
    The Ohio State University College of Dentistry, Section of Primary Care, Postle Hall Office 3058, 305 West 12th Avenue, Columbus, OH 43210, USA
    Int Dent J 54:154-8. 2004
    ..To assess the clinical and microbiological efficacy of chlorine dioxide (ClO2) as a topical antiseptic for the treatment of chronic atrophic candidiasis in geriatric patients...

Research Grants74

  1. Guided Pocket Recolonization (GPR) in Periodontitis
    Marc Quirynen; Fiscal Year: 2004
    ..Clinical data will be collected after 2, 4, 6, 8 and 12 weeks. The results should indicate the possible role for commensal organisms in periodontal disease and subgingival biofilm formation. ..
  2. Improved Macaque Safety Model for Topical Microbicides: Post-coital Assessments
    Dorothy Patton; Fiscal Year: 2008
    ..In addition, we will collect parallel assessments, when mating has occurred with a placebo gel (HEC universal placebo) in place. These studies will provide urgently needed data regarding topical microbicide use with coital activity. ..
  3. LOCAL IMMUNE RESPONSE IN CHLAMYDIA SALPINGITIS
    Dorothy Patton; Fiscal Year: 2003
    ..trachomatis- induced PID. If one chlamydial antigen is the major cause of the DTH response in PID, diagnostic or immunomodulatory efforts can be directed towards that antigen. ..
  4. Microbial Markers for Periodontal Disease in Children
    Daniel Fine; Fiscal Year: 2005
    ....
  5. Attachment of Oral Actinobacillus to Epithelium
    Daniel Fine; Fiscal Year: 2008
    ..The longterm goal of this application is to use this information to identify targets for therapeutic agents that can interfere with attachment of Aa to oral tissues and thus prevent colonization leading to LAP. [unreadable] [unreadable]..
  6. Oral Immunology/Microbiology Research Group Annual Mtg
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  7. Oral Immunology/Microbiology Annual Meeting
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  8. Incidence, risk factors, and consequences of neonatal hypothermia in Nepal
    LUKE MULLANY; Fiscal Year: 2008
    ..Examination of alternate cutoffs for defining hypothermia severity may improve design of low-cost technologies for identification and subsequent management of hypothermic infants in the community. [unreadable] [unreadable] [unreadable]..
  9. Staff Hand Hygiene and Nosocomial Infections in Neonates
    Elaine Larson; Fiscal Year: 2003
    ....
  10. Interdisciplinary Research:Antimicrobial Resistance(RMI)
    Elaine Larson; Fiscal Year: 2006
    ..In the final year, plans for a sustainable Consortium on antimicrobial resistance will be formalized. [unreadable] [unreadable]..
  11. Stopping URIs and FLU in the Family: the Stuffy Trial
    Elaine Larson; Fiscal Year: 2008
    ....
  12. HOME HYGIENE INTERVENTION
    Elaine Larson; Fiscal Year: 2002
    ..Logistic regression, Liang-Zeger regression, and Chi Square analyses will be used to test differences in rates of transmission of symptoms and changes in quantity, types and resistance patterns of microbial flora of the hands. ..
  13. Impact of Hand Hygiene Guideline on Infections and Costs
    Elaine Larson; Fiscal Year: 2005
    ..abstract_text> ..
  14. EFFLUX-MEDIATED RESISTANCE TO TETRACYCLINES
    Stuart Levy; Fiscal Year: 2006
    ..Such understanding will also enhance[unreadable] efforts to reverse efflux of other antibiotics and drugs used to treat infectious diseases, including[unreadable] bacteria, fungi and parasites, and cancer. ..
  15. Vanadocenes as a New Class of Spermicidal Drugs
    OSMOND D CRUZ; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  16. Morpholino Antisense Drugs for Hepatitis C Virus
    Nigel Bourne; Fiscal Year: 2004
    ..The proposed research, if successful, would lead to a application for Phase II funding to bring the use of PMOs into the HCV drug market and provide a well-tolerated, inexpensive alternative to current HCV treatments. ..
  17. Phase II SBIR: WHI-07: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ....
  18. Planning Grant for Xylitol Trial in Caries-Active Adults
    James Bader; Fiscal Year: 2005
    ....
  19. Linking Biophysical Functions of Microbicides to User Perception & Acceptability
    Kathleen Morrow; Fiscal Year: 2007
    ..In sum, this work will contribute methodology leading to rational design of microbicide formulations that co-optimize vaginal distribution and retention with user acceptability. ..
  20. Stampidine: A Novel Broad-Spectrum Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of STAMP in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  21. A Contextual Model of Microbicide Acceptability
    Kathleen Morrow; Fiscal Year: 2005
    ..abstract_text> ..
  22. Vaccine-elicited genital and neuronal T cell responses
    Gregg Milligan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  23. Effects of Natural Agents with Fluoride on Caries
    Hyun Koo; Fiscal Year: 2004
    ....
  24. FLP-102: Rationally Engineered Antiviral Protein
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The preclinical data on FLP-102 will be essential to further explore the utility of this novel recombinant PAP mutant for Phase II. ..
  25. EFFLUX-MEDIATED RESISTANCE TO TETRACYCLINES
    Stuart Levy; Fiscal Year: 2004
    ....
  26. MULTIPLE ANTIBIOTIC RESISTANCE (MAR) REGULON
    Stuart Levy; Fiscal Year: 2001
    ....
  27. METVAN: A Novel Anticancer Agent
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The knowledge gained from these studies described under Specific Aims 1-2 is expected to facilitate the design of innovative treatment regimens employing METVAN for metastatic breast cancer and brain tumor patients. ..
  28. PHI-443: Novel Non-Spermicidal Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of PHI-443 in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  29. PROTECTION OF GENITAL MUCOSA AND GANGLIA AGAINST HSV-2
    Gregg N Milligan; Fiscal Year: 2010
    ..The results of these studies should be important for the rational development of HSV vaccines as well as understanding the cellular interactions and specific molecular mechanisms required for resolution of HSV lesions. ..
  30. NOVEL CONTRACEPTIVES WITH ANTI-HIV ACTIVITY
    OSMOND D CRUZ; Fiscal Year: 2001
    ..The preclinical data on in vivo efficacies of WHI-05 and WHI-07 will be essential to further explore the utility of these novel drugs for clinical studies in human patients. ..
  31. Immunization to Reduce Genital and Neonatal Herpes
    Nigel Bourne; Fiscal Year: 2009
    ..These study designs may become standard for preclinical evaluation of HSV vaccines. ..
  32. PHI 346: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Following successful completion of the Phase I in vivo efficacy studies, gel formulation of PHI-346 will be further explored as a vaginal dual-function microbicide in Phase II. ..
  33. Metabolic Biomarkers of Autism: Predictive Potential and Genetic Susceptibility
    SANDRA JILL JAMES; Fiscal Year: 2010
    ....
  34. Catheter Dwell Time and Risk of Bloodstream Infections in Hospitalized Neonates
    Aaron M Milstone; Fiscal Year: 2011
    ..This project will help to develop evidence-based strategies to prevent bloodstream infections among vulnerable infants hospitalized in the neonatal intensive care unit. ..
  35. Prevention of UTI in persons with spinal cord injury
    Rabih Darouiche; Fiscal Year: 2007
    ..The PIs propose a prospective, randomized, double-blind placebo-controlled multicenter trial to evaluate the clinical efficacy of this innovative therapeutic protocol. [unreadable] [unreadable]..
  36. RISK FACTORS AS PREDICTORS OF ECTOPIC PREGNANCY
    Kurt T Barnhart; Fiscal Year: 2010
    ....
  37. Validation of a Human In Vitro Vaginal Irritation Test
    Seyoum Ayehunie; Fiscal Year: 2007
    ..The proposed human tissue based assay will provide a sensitive and specific time-efficient method to screen a large number of chemicals/formulations at a reduced cost. [unreadable] [unreadable] [unreadable]..
  38. A Structural Intervention to Enhance Female Condom Use
    Theresa Exner; Fiscal Year: 2008
    ..If effective, the intervention program, integrated into an existing statewide public health infrastructure, could serve as a model for the promotion of the FC as well as for emerging prevention. ..
  39. Resolution of Gouty Inflammation
    STEPHEN MALAWISTA; Fiscal Year: 2008
    ..We suggest further that this reprogramming of lipid mediators may explain in part the action of therapeutic agents such as colchicine, and could lead to better treatment for this condition. [unreadable] [unreadable] [unreadable]..
  40. HIV PREVENTION TRIALS UNIT - MALAWI
    Taha Taha; Fiscal Year: 2006
    ..We intend to continue these studies and to expand to additional sites. ..
  41. Intra-oral Drug Delivery Systems for HIV/AIDS Patients
    Steven Offenbacher; Fiscal Year: 2007
    ..The effective and efficient controlled drug release devices could have broad therapeutic applications in immunocompromised patients. ..
  42. Device use in Nursing Homes: Reducing Risk of Infection
    Lona Mody; Fiscal Year: 2007
    ..abstract_text> ..
  43. Ethanol and mesolimbic GABAergic neurons
    Jiang Hong Ye; Fiscal Year: 2007
    ..Such results will provide valuable information on novel mechanisms underlying the addictive properties of alcohol and a firm scientific foundation for future neurobiological studies. [unreadable] [unreadable] [unreadable]..
  44. Peer Intervention as Pedagogic Paradigm in Kinshasa SPH
    Frieda Behets; Fiscal Year: 2006
    ..Main outcome measures will be self reported sexual risk behaviors and STI/HIV incidence. The work will inform HIV prevention policy and strengthen research and training at KSPH ..
  45. Topical Microbicide Acceptability
    Alex Carballo Dieguez; Fiscal Year: 2006
    ..abstract_text> ..
  46. Neurobiol mechanism/acupuncture therapy/alcoholism
    Jiang Hong Ye; Fiscal Year: 2004
    ..This new knowledge will have a major impact on our understanding of how acupuncture works. The application of this knowledge is expected to improve the effectiveness of acupuncture treatment in alcohol addiction. ..
  47. CONTROLLED-RELEASE SEALANT TO PREVENT SECONDARY CARIES
    Kenneth Anusavice; Fiscal Year: 2004
    ..mutans, site specific levels of S. mutans at the margins of amalgam and composite restorations, and the width of marginal crevices adjacent to amalgam and composite restorations). ..
  48. DENTIST SCIENTIST AWARD--INSTITUTIONAL
    BEVERLY DALE CRUNK; Fiscal Year: 2004
    ..Ultimately, understanding the body's capability of modulating pain sensitivity may lead to improved methods in the pharmacological management of pain. ..
  49. Protease-activated receptor signaling in oral innate im*
    BEVERLY DALE CRUNK; Fiscal Year: 2005
    ..abstract_text> ..
  50. Reconstruction of skin model containing Langerhans cells
    Seyoum Ayehunie; Fiscal Year: 2003
    ..Finally, based on these studies, an assay kit to predict whether a material is likely to act as a contact allergen will be developed. ..
  51. Newborn Antiseptic Washing and Neonatal Mortality-Nepal
    James Tielsch; Fiscal Year: 2005
    ..The umbilical cord infection trial will require only one year of recruitment to obtain adequate numbers to detect a 20% in infection rates in the treatment groups. ..
  52. Clinical Models Workshop:Remin-Demin, Precavity, Caries
    George Stookey; Fiscal Year: 2005
    ..The meeting will be held on July 3-5, 2005 in the Downtown Marriott Hotel in Indianapolis, Indiana, immediately prior to the annual ORCA (European Organization for Caries Research) meeting. ..
  53. NATURAL HISTORY OF HPV--INFECTION TO NEOPLASIA
    Anna Barbara Moscicki; Fiscal Year: 2004
    ..The understanding of both local and systemic immune responses to initial and subsequent HPV infections may be key in vaccine or therapeutic developments. ..
  54. CHLORHEXIDINE IRRIGATION TO PREVENT INFECTION
    Dwight Rouse; Fiscal Year: 2001
    ....
  55. ENHANCING THE INTRACELLULAR FUNCTIONING OF HIV RIBOZYMES
    John Rossi; Fiscal Year: 2001
    ..The results from this program will greatly facilitate the effective use of ribozyme treatment for HIV-1 infection in a gene therapy setting. ..
  56. Conference: Elders' Oral Health Summit
    Judith Jones; Fiscal Year: 2004
    ....
  57. North Carolina Needs Assessment for Oral Cancer Control
    Lauren Patton; Fiscal Year: 2003
    ....
  58. Optically enhanced dental sealants to indicate placement and material condition
    George Stookey; Fiscal Year: 2006
    ..unreadable] 3) An optically doped sealant combines the efficacy advantages of a clear sealant with the visibility advantages of an opaque sealant. [unreadable] [unreadable]..
  59. EPIDERMAL GROWTH FACTOR STIMULATES WOUND HEALING IN VIVO
    Lillian Nanney; Fiscal Year: 2005
    ..This proposal places the spotlight on genes that control either a migratory or a poliferative phenotype within the complex human wound environment. ..
  60. Evalulation of Echinacea in a Human Rhinovirus Challenge
    Ronald Turner; Fiscal Year: 2003
    ....
  61. Comprehensive Research Training for Oral Health Sciences
    Frank Scannapieco; Fiscal Year: 2008
    ..Name Organization Frank A. Scannapieco University at Buffalo/Oral Biology Libuse Bobek University at Buffalo/Oral Biology Rosemary Dziak University at Buffalo/Oral Biology in the format shown below. Role on ..
  62. Amylase Binding Streptococci Dental Plaque and Caries
    Frank Scannapieco; Fiscal Year: 2008
    ..mutans made to express AbpA show altered colonization and/or cariogenic abilities. Integration of in vitro with in vivo studies is crucial for mechanistic understanding of Dental plaque formation. ..
  63. Oral Health and Ventilator Associated Pneumonia
    Frank Scannapieco; Fiscal Year: 2006
    ..abstract_text> ..
  64. Anti-Selectin Blocker for Liver Ischemic Injury
    LUIS TOLEDO PEREYRA; Fiscal Year: 2006
    ..Treatment with TCB-1269 will enhance the quality of life of millions of patients suffering from the large number of maladies associated with ischemia/reperfusion ischemic maladies. [unreadable] [unreadable]..
  65. Quantification of Host Markers in GCF Using CBIB
    Ricardo Teles; Fiscal Year: 2007
    ..Moreover, this methodology is at the forefront of new approaches in proteomics, and carries enormous promise for translational applications in the near future. [unreadable] [unreadable]..
  66. HIV 1 IMMUNITY IN THE HUMAN MALE UROGENITAL TRACT
    Deborah Anderson; Fiscal Year: 2003
    ....
  67. An In Vitro Model of Cell-Associated HIV-1 Transmission
    Deborah Anderson; Fiscal Year: 2007
    ....
  68. Infection Risk of Urinary Collection Strategies
    Sanjay Saint; Fiscal Year: 2006
    ..Since approximately 40% of elderly Americans will enter a nursing home at some point, identification of those at risk of infection could have considerable health, quality of life, and economic consequences. ..
  69. MODELS FOR TESTING CANDIDATE TOPICAL MICROBICIDES FOR CYTOTOXICITY AND ACTIVITY A
    Mary Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  70. Predictors of HIV Risk Behavior Among Men in Argentina
    Alex Carballo Dieguez; Fiscal Year: 2009
    ..This is a fundamental step prior to designing programs that mitigate those factors and result in decreased risk. ..
  71. Internet Use and HIV Risk among Men in NYC
    Alex Carballo Dieguez; Fiscal Year: 2005
    ..abstract_text> ..
  72. An In Vitro Model of Cell-Associated HIV-1 Transmission
    Deborah Anderson; Fiscal Year: 2006
    ....