antimalarials

Summary

Summary: Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)

Top Publications

  1. pmc Artemisinin resistance in Plasmodium falciparum malaria
    Arjen M Dondorp
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    N Engl J Med 361:455-67. 2009
  2. pmc Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study
    Aung Pyae Phyo
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet 379:1960-6. 2012
  3. pmc Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study
    Chanaki Amaratunga
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    Lancet Infect Dis 12:851-8. 2012
  4. pmc Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
    Arjen M Dondorp
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet 376:1647-57. 2010
  5. pmc A major genome region underlying artemisinin resistance in malaria
    Ian H Cheeseman
    Texas Biomedical Research Institute, San Antonio, TX 78245, USA
    Science 336:79-82. 2012
  6. ncbi Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasite
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
    Lancet Infect Dis 9:555-66. 2009
  7. pmc Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination
    Teun Bousema
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Clin Microbiol Rev 24:377-410. 2011
  8. ncbi Effect of the Affordable Medicines Facility--malaria (AMFm) on the availability, price, and market share of quality-assured artemisinin-based combination therapies in seven countries: a before-and-after analysis of outlet survey data
    Sarah Tougher
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 380:1916-26. 2012
  9. pmc Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator
    Jennifer A Flegg
    WorldWide Anti malarial Resistance Network WWARN and Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford, OX3 7LJ, UK
    Malar J 10:339. 2011
  10. ncbi Thousands of chemical starting points for antimalarial lead identification
    Francisco Javier Gamo
    Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Spain
    Nature 465:305-10. 2010

Detail Information

Publications360 found, 100 shown here

  1. pmc Artemisinin resistance in Plasmodium falciparum malaria
    Arjen M Dondorp
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    N Engl J Med 361:455-67. 2009
    ..There are recent concerns that the efficacy of such therapies has declined on the Thai-Cambodian border, historically a site of emerging antimalarial-drug resistance...
  2. pmc Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study
    Aung Pyae Phyo
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet 379:1960-6. 2012
    ..We aimed to establish whether artemisinin resistance has spread or emerged on the Thailand-Myanmar (Burma) border...
  3. pmc Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study
    Chanaki Amaratunga
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    Lancet Infect Dis 12:851-8. 2012
    ..We investigated contributions of both parasite genetics and host factors to the artemisinin-resistance phenotype in Pursat, western Cambodia...
  4. pmc Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
    Arjen M Dondorp
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet 376:1647-57. 2010
    ..We compared parenteral treatment with either artesunate or quinine in African children with severe malaria...
  5. pmc A major genome region underlying artemisinin resistance in malaria
    Ian H Cheeseman
    Texas Biomedical Research Institute, San Antonio, TX 78245, USA
    Science 336:79-82. 2012
    ....
  6. ncbi Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasite
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
    Lancet Infect Dis 9:555-66. 2009
    ..This Review critically examines what is known about P vivax, focusing on identifying the crucial gaps that create obstacles to the elimination of this parasite in human populations...
  7. pmc Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination
    Teun Bousema
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Clin Microbiol Rev 24:377-410. 2011
    ..These components are drawn together to show how control measures that aim to reduce malaria transmission, such as mass drug administration and a transmission-blocking vaccine, might better be deployed...
  8. ncbi Effect of the Affordable Medicines Facility--malaria (AMFm) on the availability, price, and market share of quality-assured artemisinin-based combination therapies in seven countries: a before-and-after analysis of outlet survey data
    Sarah Tougher
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 380:1916-26. 2012
    ..We present findings on the effect of AMFm on QAACT price, availability, and market share, 6-15 months after the delivery of subsidised ACTs in Ghana, Kenya, Madagascar, Niger, Nigeria, Uganda, and Tanzania (including Zanzibar)...
  9. pmc Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator
    Jennifer A Flegg
    WorldWide Anti malarial Resistance Network WWARN and Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford, OX3 7LJ, UK
    Malar J 10:339. 2011
    ..This lag complicates the clearance estimation, introduces observer subjectivity, and may influence the accuracy and consistency of reported results...
  10. ncbi Thousands of chemical starting points for antimalarial lead identification
    Francisco Javier Gamo
    Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Spain
    Nature 465:305-10. 2010
    ..Drug resistance is widespread, no new chemical class of antimalarials has been introduced into clinical practice since 1996 and there is a recent rise of parasite strains with ..
  11. ncbi Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial
    Arjen Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Lancet 366:717-25. 2005
    ..In the treatment of severe malaria, intravenous artesunate is more rapidly acting than intravenous quinine in terms of parasite clearance, is safer, and is simpler to administer, but whether it can reduce mortality is uncertain...
  12. ncbi Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials
    John J Aponte
    Barcelona Centre for International Health Research, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Lancet 374:1533-42. 2009
    ..Intermittent preventive treatment (IPT) is a promising strategy for malaria control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa...
  13. pmc Malaria in Brazil: an overview
    Joseli Oliveira-Ferreira
    Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz, FIOCRUZ, Pavilhão Leônidas Deane 5 degrees andar, Av Brasil 4365, Manguinhos, Rio de Janeiro, RJ CEP 21 045 900, RJ Brazil
    Malar J 9:115. 2010
    ....
  14. ncbi Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum
    John C Wootton
    Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894 6075, USA
    Nature 418:320-3. 2002
    ..The presence of linkage disequilibrium provides a basis for mapping genes under drug selection in P. falciparum...
  15. ncbi Production of the antimalarial drug precursor artemisinic acid in engineered yeast
    Dae Kyun Ro
    California Institute of Quantitative Biomedical Research, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Nature 440:940-3. 2006
    ..annua, yield optimization and industrial scale-up will be required to raise artemisinic acid production to a level high enough to reduce artemisinin combination therapies to significantly below their current prices...
  16. pmc Got ACTs? Availability, price, market share and provider knowledge of anti-malarial medicines in public and private sector outlets in six malaria-endemic countries
    Kathryn A O'Connell
    Population Services International, Malaria and Child Survival Department, P O Box 43640, Nairobi, Kenya
    Malar J 10:326. 2011
    ..This paper presents supply side data from ACTwatch outlet surveys in Benin, the Democratic Republic of Congo (DRC), Madagascar, Nigeria, Uganda and Zambia...
  17. ncbi Artemisinin resistance: current status and scenarios for containment
    Arjen M Dondorp
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok10400, Thailand
    Nat Rev Microbiol 8:272-80. 2010
    ..Mathematical modelling can be a useful tool to evaluate possible strategies for containment...
  18. ncbi New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance
    Ric N Price
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    Curr Opin Infect Dis 22:430-5. 2009
    ..vivax infection. We review the evidence for severe disease and the spread of drug-resistant P. vivax and speculate how these maybe related...
  19. pmc Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment
    Verena Ilona Carrara
    Shoklo Malaria Research Unit, Tak, Thailand
    PLoS ONE 4:e4551. 2009
    ....
  20. ncbi Protection against a malaria challenge by sporozoite inoculation
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    N Engl J Med 361:468-77. 2009
    ..Naturally acquired immunity to malaria develops slowly, and induction of protection in humans can be achieved artificially by the inoculation of radiation-attenuated sporozoites by means of more than 1000 infective mosquito bites...
  21. ncbi The state of the art in anti-malarial drug discovery and development
    Jeremy N Burrows
    Medicines for Malaria Venture, ICC, Geneva, Switzerland
    Curr Top Med Chem 11:1226-54. 2011
    ..This review summarises the antimalarials developed and registered thus far, as well as describing some of the new small molecule therapy approaches ..
  22. pmc Coverage of malaria protection in pregnant women in sub-Saharan Africa: a synthesis and analysis of national survey data
    Anna Maria van Eijk
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
    Lancet Infect Dis 11:190-207. 2011
    ..We aimed to synthesise data from national surveys about these interventions, accounting for disparities in malaria risk within national borders...
  23. pmc Monitoring fever treatment behaviour and equitable access to effective medicines in the context of initiatives to improve ACT access: baseline results and implications for programming in six African countries
    Megan Littrell
    Population Services International, Malaria and Child Survival Department, PO Box 43640, Nairobi, Kenya, Africa
    Malar J 10:327. 2011
    ..These data provide a baseline for monitoring interventions to increase ACT coverage, such as the Affordable Medicines Facility for malaria (AMFm)...
  24. ncbi Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi
    James G Kublin
    Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 187:1870-5. 2003
    ..The reintroduction of chloroquine, ideally in combination with another antimalarial drug, should be considered in areas where chloroquine resistance has declined and safe and affordable alternatives remain unavailable...
  25. pmc Community case management of malaria using ACT and RDT in two districts in Zambia: achieving high adherence to test results using community health workers
    Pascalina Chanda
    Department of Public Health and Research, Ministry of Health Headquarters, Lusaka, Zambia
    Malar J 10:158. 2011
    ..WHO recommends home management of malaria using artemisininbased combination therapy (ACT) and Rapid Diagnostic tests (RDTs) as one of the strategies for improving access to prompt and efective malaria case management...
  26. pmc Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue
    Sophie H Adjalley
    Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 108:E1214-23. 2011
    ..Efforts to measure the activity of existing antimalarials on intraerythrocytic sexual stage gametocytes and identify transmission-blocking agents have, until now, been ..
  27. pmc Severe Plasmodium knowlesi malaria in a tertiary care hospital, Sabah, Malaysia
    Timothy William
    Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysian Borneo
    Emerg Infect Dis 17:1248-55. 2011
    ..P. knowlesi is a major cause of severe and fatal malaria in Sabah. Artemisinin derivatives rapidly clear parasitemia and are efficacious in treating uncomplicated and severe knowlesi malaria...
  28. pmc Improved diagnostic testing and malaria treatment practices in Zambia
    Davidson H Hamer
    Center for International Health and Development, Boston University School of Public Health, Boston, Mass 02118, USA
    JAMA 297:2227-31. 2007
    ....
  29. ncbi From malaria control to eradication: The WHO perspective
    Kamini Mendis
    Global Malaria Programme, World Health Organization, Geneva, Switzerland
    Trop Med Int Health 14:802-9. 2009
    ..The prospects of malaria eradication, therefore, rest heavily on the outcomes of research and development for new and improved tools. Malaria control and elimination are complementary objectives in the global fight against malaria...
  30. pmc Spiroindolones, a potent compound class for the treatment of malaria
    Matthias Rottmann
    Swiss Tropical and Public Health Institute, Parasite Chemotherapy, CH 4002 Basel, Switzerland
    Science 329:1175-80. 2010
    Recent reports of increased tolerance to artemisinin derivatives--the most recently adopted class of antimalarials--have prompted a need for new treatments...
  31. pmc The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites
    Michael Delves
    Department of Life Sciences, Imperial College London, London, UK
    PLoS Med 9:e1001169. 2012
    ..These new medicines are needed both to meet the challenge of malaria eradication and to circumvent resistance...
  32. pmc The magnitude and trend of artemether-lumefantrine stock-outs at public health facilities in Kenya
    Raymond K Sudoi
    Malaria Public Health and Epidemiology Group, KEMRI Wellcome Trust Research Programme, PO Box 43640, 00100 GPO Nairobi, Kenya
    Malar J 11:37. 2012
    ..Here, 2010-2011 data are reported from public facilities in Kenya where alarming stock-outs were revealed in 2008...
  33. pmc Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery
    Stephan Meister
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 334:1372-7. 2011
    ..The open-source chemical tools resulting from our effort provide starting points for future drug discovery programs, as well as opportunities for researchers to investigate the biology of exo-erythrocytic forms...
  34. pmc Malaria case-management following change of policy to universal parasitological diagnosis and targeted artemisinin-based combination therapy in Kenya
    Andrew Nyandigisi
    Division of Malaria Control, Ministry of Public Health and Sanitation, Nairobi, Kenya
    PLoS ONE 6:e24781. 2011
    ..We evaluated changes in health systems and case-management indicators between the baseline survey undertaken before implementation of the policy and the follow-up survey following the first year of the implementation activities...
  35. pmc Community case management of fever due to malaria and pneumonia in children under five in Zambia: a cluster randomized controlled trial
    Kojo Yeboah-Antwi
    Center for Global Health and Development, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 7:e1000340. 2010
    ..This study was designed to assess the effectiveness and feasibility of using CHWs to manage nonsevere pneumonia and uncomplicated malaria with the aid of rapid diagnostic tests (RDTs)...
  36. pmc Clinical and laboratory features of human Plasmodium knowlesi infection
    Cyrus Daneshvar
    Malaria Research Centre, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Malaysia
    Clin Infect Dis 49:852-60. 2009
    ..Plasmodium knowlesi is increasingly recognized as a cause of human malaria in Southeast Asia but there are no detailed prospective clinical studies of naturally acquired infections...
  37. ncbi Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
    M B Reed
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Nature 403:906-9. 2000
    ..However, conclusive evidence of a direct causal association between pfmdr1 and resistance to these antimalarials has remained elusive, and a single genetic cross has suggested that Pgh1 is not involved in resistance to ..
  38. pmc Malaria indicator survey 2007, Ethiopia: coverage and use of major malaria prevention and control interventions
    Daddi Jima
    Diseases Prevention and Control Department, Federal Ministry of Health, Addis Ababa, Ethiopia
    Malar J 9:58. 2010
    ....
  39. ncbi Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Lancet 377:1770-6. 2011
    ..This immunity was associated with parasite-specific production of interferon γ and interleukin 2 by pluripotent effector memory cells in vitro. We aim to explore the persistence of protection and immune responses in the same volunteers...
  40. ncbi Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 195:927-33. 2007
    ..Thus, reappearance of parasitemia after treatment can result from relapse, recrudescence, or reinfection. It has been assumed that parasites causing relapse would be a subset of the parasites that caused the primary infection...
  41. pmc Chemical genetics of Plasmodium falciparum
    W Armand Guiguemde
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 465:311-5. 2010
    ..falciparum and related protozoans. One exemplar compound displayed efficacy in a murine model. Our findings provide the scientific community with new starting points for malaria drug discovery...
  42. ncbi Artemisinin resistance in Cambodia: a clinical trial designed to address an emerging problem in Southeast Asia
    Harald Noedl
    Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria
    Clin Infect Dis 51:e82-9. 2010
    ..This article provides additional data from a clinical trial that has been published in The New England Journal of Medicine...
  43. ncbi Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan Africa
    Laith J Abu-Raddad
    Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 314:1603-6. 2006
    ..Hence, transient and repeated increases in HIV viral load resulting from recurrent co-infection with malaria may be an important factor in promoting the spread of HIV in sub-Saharan Africa...
  44. pmc Marked increase in child survival after four years of intensive malaria control
    Immo Kleinschmidt
    London School of Hygiene and Tropical Medicine, London, United Kingdom Medical Care Development International, Silver Spring, Maryland
    Am J Trop Med Hyg 80:882-8. 2009
    ..34 [95% CI = 0.23-0.49]). Effective malaria control measures can dramatically increase child survival and play a key role in achieving millennium development goals...
  45. ncbi Getting antimalarials on target: impact of national roll-out of malaria rapid diagnostic tests on health facility treatment in three regions of Tanzania
    Katia Bruxvoort
    London School of Hygiene and Tropical Medicine, London, UK Ifakara Health Institute, Dar es Salaam, Tanzania
    Trop Med Int Health 18:1269-82. 2013
    ..To evaluate the impact on case management practices of routine government implementation of mRDTs, we conducted large-scale health facility surveys in three regions of Tanzania before and after mRDT roll-out...
  46. pmc Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia
    Benoit Witkowski
    Malaria Molecular Epidemiology Unit, Institut Pasteur in Cambodia, Phnom Penh, Cambodia
    Antimicrob Agents Chemother 57:914-23. 2013
    ..The reduced susceptibility to artemisinin in Pailin appears to be associated with an altered in vitro phenotype of ring stages from Pailin in the RSA...
  47. ncbi Chemoresistance of Plasmodium falciparum and Plasmodium vivax parasites in Brazil: consequences on disease morbidity and control
    Bianca Ervatti Gama
    Centro de Pesquisa em Malária, Centro de Pesquisa, Diagnóstico e Treinamento em Malária, Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro, RJ, Brasil
    Mem Inst Oswaldo Cruz 106:159-66. 2011
    ..Additionally, in vivo, in vitro and molecular studies as well as malaria chemoresistance consequences on disease morbidity and policy treatment guidelines were commented...
  48. pmc The combined effect of determinants on coverage of intermittent preventive treatment of malaria during pregnancy in the Kilombero Valley, Tanzania
    Karin Gross
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Malar J 10:140. 2011
    ..This paper investigates the combined impact of pregnant women's timing of ANC attendance, health workers' IPTp delivery and different delivery schedules of national IPTp guidelines on IPTp coverage...
  49. pmc Global phenotypic screening for antimalarials
    W Armand Guiguemde
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Chem Biol 19:116-29. 2012
    ..To compound the problem, drug resistance has emerged to all classical antimalarials and may be emerging for artemisinin-based combination therapies...
  50. pmc A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development
    Benoit Malleret
    Laboratory of Malaria Immunobiology, Singapore Immunology Network SIgN, Agency for Science, Technology and Research A STAR, Biopolis, Singapore
    Sci Rep 1:118. 2011
    ..It also allows assessing the proportion of parasites at different developmental stages. Lastly, we demonstrate how this technique can be applied to antimalarial drug testing...
  51. pmc Routine delivery of artemisinin-based combination treatment at fixed health facilities reduces malaria prevalence in Tanzania: an observational study
    Rashid A Khatib
    Ifakara Health Institutce, Dar es Salaam, Tanzania
    Malar J 11:140. 2012
    ....
  52. pmc Piloting the global subsidy: the impact of subsidized artemisinin-based combination therapies distributed through private drug shops in rural Tanzania
    Oliver J Sabot
    Malaria Control Team, Clinton Foundation HIV AIDS Initiative, Boston, Massachusetts, USA
    PLoS ONE 4:e6857. 2009
    ..To overcome this challenge, a global ACT subsidy has been proposed. We tested this proposal through a pilot program in rural Tanzania...
  53. pmc P. falciparum in vitro killing rates allow to discriminate between different antimalarial mode-of-action
    Laura M Sanz
    Tres Cantos Medicine Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
    PLoS ONE 7:e30949. 2012
    ..This approach has been adapted to perform medium throughput screening, facilitating the identification of fast-acting antimalarial compounds, which are crucially needed for the control and possibly the eradication of malaria...
  54. ncbi Intercontinental spread of pyrimethamine-resistant malaria
    Cally Roper
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Science 305:1124. 2004
    ..The resistance alleles carried by these migrants are now spreading across Africa at an alarming rate, signaling the end of affordable malaria treatment and presenting sub-Saharan Africa with a public health crisis...
  55. ncbi Reducing the burden of malaria in pregnancy by preventive strategies
    Clara Menendez
    Center for International Health, Hospital Clinic Barcelona University, Barcelona, Spain
    Lancet Infect Dis 7:126-35. 2007
    ....
  56. pmc Dihydroartemisinin-piperaquine versus chloroquine in the treatment of Plasmodium vivax malaria in Thailand: a randomized controlled trial
    Aung Pyae Phyo
    Shoklo Malaria Research Unit, Mae Sod
    Clin Infect Dis 53:977-84. 2011
    ..Chloroquine (CQ) remains the treatment of choice for Plasmodium vivax malaria. Initially confined to parts of Indonesia and Papua, resistance of P. vivax to CQ seems to be spreading, and alternative treatments are required...
  57. pmc Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum
    Connor O'Brien
    Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Curr Opin Infect Dis 24:570-7. 2011
    ..However, recent reports from the Thai-Cambodian border reveal evidence of emerging resistance to artemisinins. The latest published clinical and molecular findings are summarized herein...
  58. ncbi Drug-resistant malaria: molecular mechanisms and implications for public health
    Ines Petersen
    Department of Infectious Diseases, Parasitology, Universitatsklinikum Heidelberg, Heidelberg, Germany
    FEBS Lett 585:1551-62. 2011
    ..This review attempts to summarize the unique factors presented by malarial parasites that lead to the emergence and spread of drug resistance, and gives an overview of known resistance mechanisms to currently used antimalarial drugs...
  59. pmc Major reduction in anti-malarial drug consumption in Senegal after nation-wide introduction of malaria rapid diagnostic tests
    Sylla Thiam
    Programme National de Lutte contre le Paludisme, Ministere de la Sante, Dakar Fann, Senegal
    PLoS ONE 6:e18419. 2011
    ..This paper assesses the impact of this programme on anti-malarial drug consumption and disease reporting...
  60. pmc Reductions in malaria and anaemia case and death burden at hospitals following scale-up of malaria control in Zanzibar, 1999-2008
    Maru W Aregawi
    World Health Organization, Global Malaria Programme, 20 Avenue Appia 1211 Geneva 27, Switzerland
    Malar J 10:46. 2011
    ..The impact of the scale-up of insecticide-treated nets (ITN), indoor-residual spraying (IRS) and artemisinin-combination therapy (ACT) combined on malaria burden was assessed at six out of seven in-patient health facilities...
  61. pmc Use of RDTs to improve malaria diagnosis and fever case management at primary health care facilities in Uganda
    Daniel J Kyabayinze
    Malaria Consortium Africa, Plot 2, Sturrock Road, PO Box 8045, Kampala, Uganda
    Malar J 9:200. 2010
    ..This study evaluated the effect of malaria RDTs on health workers' anti-malarial drug (AMD) prescriptions among outpatients at low level health care facilities (LLHCF) within different malaria epidemiological settings in Uganda...
  62. pmc Resistance to therapies for infection by Plasmodium vivax
    J Kevin Baird
    Eijkman Oxford Clinical Research Unit, Jalan Diponegoro No 69, Jakarta 10430, Indonesia
    Clin Microbiol Rev 22:508-34. 2009
    ....
  63. pmc The parasite clearance curve
    N J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 10:278. 2011
    ..The factors affecting parasite clearance are reviewed. Methods of presentation and the approaches to analysis are discussed...
  64. pmc Reduction of anti-malarial consumption after rapid diagnostic tests implementation in Dar es Salaam: a before-after and cluster randomized controlled study
    Valérie D'Acremont
    Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland
    Malar J 10:107. 2011
    ..Presumptive treatment of all febrile patients with anti-malarials leads to massive over-treatment. The aim was to assess the effect of implementing malaria rapid diagnostic tests (mRDTs) on prescription of anti-malarials in urban Tanzania...
  65. pmc Chloroquine-resistant Plasmodium vivax, Brazilian Amazon
    Franklin Simoes de Santana Filho
    Emerg Infect Dis 13:1125-6. 2007
  66. pmc Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial
    Frank Smithuis
    Medecins Sans Frontieres Holland, Yangon, Myanmar
    Lancet Infect Dis 10:673-81. 2010
    ..We aimed to compare effectiveness of four fixed-dose ACTs and a loose tablet combination of artesunate and mefloquine, and assess the addition of a single gametocytocidal dose of primaquine...
  67. pmc The potential contribution of mass treatment to the control of Plasmodium falciparum malaria
    Lucy C Okell
    Department of Infectious Disease Epidemiology, MRC Centre for Outbreak Analysis and Modeling, Imperial College London, London, United Kingdom
    PLoS ONE 6:e20179. 2011
    ..The benefits of mass treatment need to be carefully weighed against the risks of increasing drug selection pressure...
  68. pmc In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen
    David Plouffe
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 105:9059-64. 2008
    ..To facilitate the discovery of new antimalarials, we have implemented an efficient and robust high-throughput cell-based screen (1,536-well format) based on ..
  69. pmc Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening
    Martin Smilkstein
    Medical Research Service, Department of Veterans Affairs Medical Center, Oregon Health and Science University, Portland, Oregon, USA
    Antimicrob Agents Chemother 48:1803-6. 2004
    ..The results obtained with this new fluorescence assay suggest that it may be an ideal method for high-throughput antimalarial drug screening...
  70. pmc Adherence to a six-dose regimen of artemether-lumefantrine among uncomplicated Plasmodium falciparum patients in the Tigray Region, Ethiopia
    Hailemariam Lemma
    Tigray Health Bureau, Mekelle, Ethiopia
    Malar J 10:349. 2011
    ..The aim of this study was to measure patient adherence levels to the six-dose AL regimen for the treatment of uncomplicated P. falciparum malaria and to identify its determinant factors in rural areas of the Tigray region, Ethiopia..
  71. pmc Medicine sellers and malaria treatment in sub-Saharan Africa: what do they do and how can their practice be improved?
    Catherine Goodman
    Health Economics and Financing Programme, Health Policy Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom
    Am J Trop Med Hyg 77:203-18. 2007
    ..Interventions must be adapted to include artemisinin-based combination therapies, and their sustainability and potential to operate at a national level should be further explored...
  72. pmc Pyronaridine-artesunate versus chloroquine in patients with acute Plasmodium vivax malaria: a randomized, double-blind, non-inferiority trial
    Yi Poravuth
    National Malaria Center, Phnom Penh, Cambodia
    PLoS ONE 6:e14501. 2011
    New antimalarials are needed for P. vivax and P. falciparum malaria. This study compared the efficacy and safety of pyronaridine-artesunate with that of chloroquine for the treatment of uncomplicated P. vivax malaria.
  73. pmc Socially-marketed rapid diagnostic tests and ACT in the private sector: ten years of experience in Cambodia
    Shunmay Yeung
    Department of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London WC1H 9SH, UK
    Malar J 10:243. 2011
    ..In Cambodia, this is particularly complicated due to problems inherent to the drug itself and the emergence of artemisinin resistance...
  74. pmc Severe Plasmodium vivax malaria, Brazilian Amazon
    Márcia A Alexandre
    Fundacao de Medicina Tropical do Amazonas, Manaus, Brazil
    Emerg Infect Dis 16:1611-4. 2010
    ..The major complications were jaundice and severe anemia. No in vivo chloroquine resistance was detected. These data help characterize the clinical profile of severe P. vivax malaria in Latin America...
  75. pmc Options for the delivery of intermittent preventive treatment for malaria to children: a community randomised trial
    Margaret Kweku
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 4:e7256. 2009
    ..We have evaluated the coverage of IPTc that can be achieved by two different delivery systems in Ghana...
  76. ncbi Primaquine therapy for malaria
    J Kevin Baird
    US Naval Medical Research Center Detachment, Lima, Peru
    Clin Infect Dis 39:1336-45. 2004
    ..5 mg/kg primaquine daily for 14 days, on the basis of superior efficacy and good tolerability and safety in nonpregnant persons without glucose-6-phosphate dehydrogenase deficiency...
  77. pmc Artemisinin combination therapy for vivax malaria
    Nicholas M Douglas
    Menzies School of Health Research, Darwin, NT, Australia
    Lancet Infect Dis 10:405-16. 2010
    ..Analyses of the cost-effectiveness of ACTs for both Plasmodium species are needed to assess the role of these drugs in the control and elimination of vivax malaria...
  78. pmc Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance
    Bruno B Andrade
    Centro de Pesquisas Gonçalo Moniz CPqGM, Fundação Oswaldo Cruz FIOCRUZ, Salvador, Bahia, Brazil
    Malar J 9:13. 2010
    ..In this report, the inflammatory and immunological status of both mild and severe vivax malaria cases are compared in order to explore immunopathological events in this disease...
  79. pmc Chloroquine resistance before and after its withdrawal in Kenya
    Leah Mwai
    Kenya Medical Research Institute Wellcome Trust Collaborative Research Programme, Kilifi, Kenya
    Malar J 8:106. 2009
    ..Changes to those that occurred in the dihydrofolate reductase gene (dhfr) that confers resistance to the replacement drug, pyrimethamine/sulphadoxine were also compared...
  80. pmc Rapid testing for malaria in settings where microscopy is available and peripheral clinics where only presumptive treatment is available: a randomised controlled trial in Ghana
    Evelyn K Ansah
    Dangme West District Health Directorate, Dodowa, Ghana
    BMJ 340:c930. 2010
    To test in West Africa the impact of rapid diagnostic tests on the prescription of antimalarials and antibiotics both where microscopy is used for the diagnosis of malaria and in clinical (peripheral) settings that rely on clinical ..
  81. ncbi Effect of malaria rapid diagnostic tests on the management of uncomplicated malaria with artemether-lumefantrine in Kenya: a cluster randomized trial
    Jacek Skarbinski
    Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
    Am J Trop Med Hyg 80:919-26. 2009
    ..30). RDTs could potentially improve malaria case management, but we urgently need to develop more effective strategies for implementing guidelines before large scale implementation...
  82. pmc Severe imported falciparum malaria: a cohort study in 400 critically ill adults
    Fabrice Bruneel
    Service de Reanimation, Centre Hospitalier de Versailles, Le Chesnay, France
    PLoS ONE 5:e13236. 2010
    ..We sought to describe the clinical spectrum of severe imported malaria in French adults and to identify risk factors for mortality at admission to the intensive care unit...
  83. ncbi In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem)
    Christin Sisowath
    Malaria Research Laboratory, Unit of Infectious Diseases, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
    J Infect Dis 191:1014-7. 2005
    ..This points to 86N as a potential marker of lumefantrine resistance in vivo, while suggesting that Coartem is not robust enough to avoid selection of resistance-associated mutations in some malarial settings...
  84. pmc Impact of malaria at the end of pregnancy on infant mortality and morbidity
    Azucena Bardaji
    Barcelona Centre for International Health Research and Department of Pathology, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Spain
    J Infect Dis 203:691-9. 2011
    ..There is some consensus that malaria in pregnancy may negatively affect infant's mortality and malaria morbidity, but there is less evidence concerning the factors involved...
  85. ncbi Withholding antimalarials in febrile children who have a negative result for a rapid diagnostic test
    Valérie D'Acremont
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Clin Infect Dis 51:506-11. 2010
    ..The objective of the present study was to evaluate the safety of withholding antimalarials in febrile children who have a negative test result.
  86. pmc Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria: a randomised controlled trial
    Boubacar Coulibaly
    Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso
    PLoS ONE 4:e5318. 2009
    ..We here report on the effects of methylene blue (MB)-based malaria combination therapy on gametocytaemia during a randomised-controlled trial in Burkina Faso...
  87. pmc A high-throughput screen targeting malaria transmission stages opens new avenues for drug development
    Kathrin Buchholz
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Infect Dis 203:1445-53. 2011
    ..is widespread, and there is an urgent need for novel approaches to reduce the emergence of resistance to new antimalarials as they are introduced...
  88. pmc Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance
    Maria Isabel Veiga
    Malaria Research Lab, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e20212. 2011
    ..Our work unveils new candidate markers of P. falciparum multidrug resistance in vitro, while contributing to the understanding of subjacent genetic complexity, essential for future evidence-based drug policy decisions...
  89. pmc Poor quality vital anti-malarials in Africa - an urgent neglected public health priority
    Paul N Newton
    Wellcome Trust Mahosot Hospital Oxford University Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
    Malar J 10:352. 2011
    ..A vital component of malaria control rests on the availability of good quality artemisinin-derivative based combination therapy (ACT) at the correct dose. However, there are increasing reports of poor quality anti-malarials in Africa...
  90. pmc Treatment outcome of intravenous artesunate in patients with severe malaria in the Netherlands and Belgium
    Annemarie R Kreeftmeijer-Vegter
    Department of Internal Medicine, Division of Infectious Diseases, Academic Medical Center, Amsterdam, The Netherlands
    Malar J 11:102. 2012
    ..Fortunately, artesunate became available in the Netherlands and Belgium through a named patient programme. This is the largest case series of artesunate treated patients with severe malaria in Europe...
  91. pmc Malaria misdiagnosis in Uganda--implications for policy change
    Joan Nankabirwa
    Malaria Consortium, Africa Regional Office, Kampala, Uganda
    Malar J 8:66. 2009
    ..In this study, the policy implications of such recommendations are revisited...
  92. ncbi In vivo parasitological measures of artemisinin susceptibility
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
    J Infect Dis 201:570-9. 2010
    ....
  93. pmc How can malaria rapid diagnostic tests achieve their potential? A qualitative study of a trial at health facilities in Ghana
    Clare I R Chandler
    Clinical Research Unit, London School of Hygiene and Tropical Medicine Keppel Street, London, WC1E 7HT, UK
    Malar J 9:95. 2010
    ..A recent trial in rural health facilities in Ghana reduced overprescription of anti-malarials, but found that 45.5% patients who tested negative with RDTs were still prescribed an anti-malarial...
  94. ncbi Molecular analysis of pfatp6 and pfmdr1 polymorphisms and their association with in vitro sensitivity in Plasmodium falciparum isolates from the Thai-Myanmar border
    Papichaya Phompradit
    Thailand Center of Excellence on Drug Discovery and Development, Thammasat University, Rangsit Campus, Patumthani 12121, Thailand
    Acta Trop 120:130-5. 2011
    ..No association between mutation or amplification of pfatp6 gene and in vitro susceptibility of P. falciparum isolates was found...
  95. pmc High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia
    Tim J C Anderson
    Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, Texas 78245, USA
    J Infect Dis 201:1326-30. 2010
    ....
  96. pmc Accuracy of malaria rapid diagnostic tests in community studies and their impact on treatment of malaria in an area with declining malaria burden in north-eastern Tanzania
    Deus S Ishengoma
    National Institute for Medical Research, Tanga Medical Research Centre, P O Box 5004, Tanga, Tanzania
    Malar J 10:176. 2011
    ....
  97. ncbi Spread and evolution of Plasmodium falciparum drug resistance
    Toshihiro Mita
    Department of International Affairs and Tropical Medicine, Tokyo Women s Medical University, School of Medicine, 9 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Parasitol Int 58:201-9. 2009
    Worldwide spread of Plasmodium falciparum drug resistance to conventional antimalarials, chloroquine and sulfadoxine/pyrimethamine, has been imposing a serious public health problem in many endemic regions...
  98. pmc Impact of intermittent preventive treatment with sulphadoxine-pyrimethamine targeting the transmission season on the incidence of clinical malaria in children in Mali
    Alassane Dicko
    Malaria Research and Training Center, Departments of Epidemiology of Parasitic Diseases, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, P O Box 1805, Bamako, Mali
    Malar J 7:123. 2008
    ..However in most areas malaria morbidity and mortality remain high in older children...
  99. pmc Molecular markers of resistance to sulphadoxine-pyrimethamine one year after implementation of intermittent preventive treatment of malaria in infants in Mali
    Alassane Dicko
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, PO Box 1805 Bamako, Mali
    Malar J 9:9. 2010
    ..However, there is a fear that IPTi may result in a rapid increase of parasite resistance to SP...
  100. pmc Cost savings with rapid diagnostic tests for malaria in low-transmission areas: evidence from Dar es Salaam, Tanzania
    Joshua Yukich
    Department of International Health and Development, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, Suite 2200 TB46, New Orleans, LA 70112 2715, USA
    Am J Trop Med Hyg 83:61-8. 2010
    ..002). The RDTs reduced drug costs in this setting but did not offset the cost of the tests, although they also resulted in non-monetary benefits, including improved management of patients and increased compliance with test results...
  101. pmc Intermittent screening and treatment versus intermittent preventive treatment of malaria in pregnancy: a randomised controlled non-inferiority trial
    Harry Tagbor
    Department of Community Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
    PLoS ONE 5:e14425. 2010
    ..Therefore, we have investigated whether screening with a rapid diagnostic test and treatment of those who are positive (IST) at routine antenatal clinic attendances is as effective and as safe as SP-IPTp in pregnant women...

Research Grants78

  1. Latin American Center for Malaria Research and Control
    SOCRATES HERRERA VALENCIA; Fiscal Year: 2013
    ..is endemic, including adherence, self-medication and prophylaxis;and (b) study the conditions of use of antimalarials in the public and private health institutions including the availability and suitability to care guides...
  2. Development of Small Antimicrobial Peptide Mimics as Drug-Resistant and Susceptib
    Richard W Scott; Fiscal Year: 2013
    ..We propose that antimicrobial peptides (AMPs) may provide the basis of a novel class of antimalarials. AMPs are an essential component of the innate immune system...
  3. Molecular epidemiology of drug resistance and population genetic structure of Pla
    Fangli Lu; Fiscal Year: 2013
    ..vivax transmission in Yunnan and Hainan, China. 1 ..
  4. Identification of G6PD inhibitors for the development of novel antimalarial drugs
    Lars Bode; Fiscal Year: 2010
    ..We aim at identifying compounds that inhibit this enzyme both in malaria parasites and, to a certain extent, in humans. Our results may pave the way for the development of novel antimalarial drugs. ..
  5. Pilot studies of the molecular epidemiology of drug-resistant malaria in Myanmar
    Christopher V Plowe; Fiscal Year: 2013
    ..This work is expected to contribute to the development of robust surveillance tools that can be used to track and contain artemisinin resistance in Southeast Asia and elsewhere. ..
  6. Purine Pathways and Inhibitor Design in Plasmodium
    Vern L Schramm; Fiscal Year: 2012
    ..The parasite has acquired resistance against most antimalarials and new drugs are required. P...
  7. Functional genomic analysis of host determinants of malaria infection
    Elizabeth Egan; Fiscal Year: 2013
    ..The results of this work will ultimately guide the rational development of host-targeted therapeutics for malaria. ..
  8. Tulane-Xavier Minority Training in International Health
    Richard A Oberhelman; Fiscal Year: 2013
    ....
  9. Mitochondrial Functions in Malaria Parasites
    Akhil B Vaidya; Fiscal Year: 2013
    ..at the cytochrome bc1 complex by at least 3 additional chemical classes of compounds under development as antimalarials. We showed that a critical function of mtETC in Plasmodium falciparum blood stages was to serve as an electron ..
  10. Inhibition of Autophagy: A Novel Therapeutic Strategy for Advanced Solid Tumors
    Francis J Giles; Fiscal Year: 2010
    ....
  11. Designed Antimalarial Agents Overcoming Chloroquine-Resistance
    David H Peyton; Fiscal Year: 2010
    ..This work is to develop further promising lead candidates from a new class of drugs, `reversed chloroquines'(RCQs), designed to overcome this resistance. ..
  12. Malaria melatonin receptor signaling as a novel drug target
    Andrew P Thomas; Fiscal Year: 2013
    ..Techniques include live-cell fluorescence imaging, imaging flow cytometry, in vivo malaria models, and synthetic chemistry. ..
  13. Perturbations of host cell signaling by a complex hepatotropic pathogen
    Stefan H I Kappe; Fiscal Year: 2013
    ..Perturbations of hepatocyte signaling by a complex intracellular pathogen might also reveal new intrinsic features of the signaling system within hepatocytes. ..
  14. Development of an activity based probe family for metallo aminopeptidases
    Doron Greenbaum; Fiscal Year: 2010
    ..causes most malaria associated deaths, has now become a major problem necessitating the discovery of novel antimalarials. Peptidases participate in several critical pathways during the life cycle of P...
  15. Function and Inhibition of Plasmodium Lipid Decarboxylases
    Choukri Ben Mamoun; Fiscal Year: 2013
    ..falciparum development as well as fostering the design of specific inhibitors. This work will provide new therapeutic insights for combating a disease that affects 250 million people worldwide and causes 1 million deaths each year. ..
  16. Optimizing Novel Dihydroorotate Dehydrogenase Inhibitors for Treating Malaria
    David Waterson; Fiscal Year: 2011
    ..Once a compound has been nominated, MMV will fund and manage the GLP preclinical development program and First in Human (FIH) Phase 1 clinical trials as part of its internally funded clinical development program. ..
  17. Optimization of pyrimidinyl prodrugs (PYPs) for malaria chemotherapy
    PRADIPSINH RATHOD; Fiscal Year: 2009
    ..to potency, safety, cost of goods, low propensity for resistance, and lack of cross-resistance to other antimalarials, 6-carboxy-2,4-dioxo-5- fluoropyrimidine (5-fluoroorotate or PYP1) stands out as the best hit...
  18. Small molecule protein-glycan inhib. as malaria transmission-blocking therapuetic
    RHOEL DAVID RAMOS DINGLASAN; Fiscal Year: 2013
    ..This strategy is especially important given that many current antimalarials and vaccine candidates still permit transmission of the parasite through the mosquito, moreover, our lead ..
  19. Blood Filtration System for the Treatment of Severe Malaria Patients
    Alberto Gandini; Fiscal Year: 2013
    ..abstract_text> ..
  20. Optimizing Pharmachins for Treatment and Prevention of Drug Resistant Malaria
    MICHAEL KEVIN RISCOE; Fiscal Year: 2013
    ..The resultant advantages of avoiding drug toxicity, febrile illness and complex medical management during deployment are also self-evident, as are the benefits to both short and long-term health of the US soldier. ..
  21. Defining the targets of broad intervention antimalarial agents
    Elizabeth A Winzeler; Fiscal Year: 2013
    ....
  22. Sustainable Financial Incentives To Improve Prescription Practices For Malaria
    WENDY PRUDHOMME O'MEARA; Fiscal Year: 2013
    ..tests (RDTs) are available, between 50-80% of patients with a negative test are nonetheless prescribed antimalarials. Inappropriately treated fevers in children can lead to serious consequences for the patient and can ..
  23. Efficacy evaluation of traditionally used antimalarial plants
    ROCKY T GRAZIOSE; Fiscal Year: 2012
    ..Currently, no drugs are universally successful in treating malaria due to widespread drug resistance;new antimalarials are desperately needed...
  24. Ruthenium-based antimalarial agents
    ROBERTO A SANCHEZ-DELGADO; Fiscal Year: 2013
    ..This proposal presents a promising alternative toward the development of novel and effective metal-based antimalarial therapies and it opens important avenues of research for understanding their mechanisms of action. ..
  25. Discovering new compounds to treat global infectious disease
    Emily R Derbyshire; Fiscal Year: 2013
    ..In these areas, parasites can rapidly develop drug resistance, which erodes the efficacy of antimalarials. Thus new drugs and the identification of novel targets are desperately needed to treat malaria...
  26. Immunologic consequences of highly effective antimalarial chemoprevention
    Prasanna Jagannathan; Fiscal Year: 2013
    ..At the completion of this award, Dr. Jagannathan will be well positioned to develop an R01 application to further define correlates and mechanisms of protective immunity to malaria. ..
  27. Discovery of chemically validated malaria liver stage targets
    Elizabeth A Winzeler; Fiscal Year: 2013
    ..The inability to eliminate cryptic liver forms creates a barrier to malaria eradication. We propose to find new targets that are critical to the liver stages as well as the blood stages with the long term aim of designing better drugs. ..
  28. Novel Plasmodial Surface Anion Channel Inhibitors as Antimalarial Drugs
    Michelle M Butler; Fiscal Year: 2013
    ..provided by applicant): The overall objective of this project is to generate new, potent, selective antimalarials that act through a novel mechanism of blocking the plasmodial surface anion channel (PSAC), a previously ..
  29. Testing feasibility of artemisinin-based synthetic-lethal suppression of skin pho
    Georg T Wondrak; Fiscal Year: 2013
    ..Critical proof-of-principle data will be generated guiding the rational design of future mechanistic and preclinical studies that validate synthetic-lethal approaches for photochemoprevention. ..
  30. Identifaction of the genetic basis of primaquine resistance in malaria parasites
    ERIKA LEA FLANNERY; Fiscal Year: 2013
    ..Identification of these determinants will inform the development of new antimalarials that target liver-stage P. vivax...
  31. Identification of Novel Plant-derived Antimalarial Compounds
    Susan L Mooberry; Fiscal Year: 2012
    ..To date no malaria vaccine has been developed and parasites resistant to all classes of antimalarials exist in many areas of the world...
  32. High Throughput Screens for Malaria Topoisomerases
    Pradipsinh K Rathod; Fiscal Year: 2013
    ..The search for new antimalarials will be greatly aided by a High Throughput Assay (HTA) for Plasmodium topoisomerases, since such enzymes are ..
  33. Lead optimization of DHODH inhibitors for malaria
    Margaret A Phillips; Fiscal Year: 2013
    ..public private partnerships such as Medicines for Malaria Venture (MMV) to manage the development of new antimalarials. MMV has the largest drug development pipeline for anti malarials world-wide and is involved in projects ..
  34. Establishment of a high throughput screen for the discovery of malaria transmissi
    Matthias Marti; Fiscal Year: 2010
    ..The goal of this work is the discovery of small molecules that could be developed into transmission blocking drugs. ..
  35. Evaluation of Small Molecule Inhibitors of Hemoglobin Transport as Antimalarials
    Theodore F Taraschi; Fiscal Year: 2012
    ..Perturbing the hemoglobin transport system represents a unique approach for developing antimalarials. Given the urgent need for new drug targets and antimalarials and the millions of people worldwide afflicted ..
  36. Chemical Methods for Ferrous Iron Targeted Drug Delivery
    ADAM ROBERT RENSLO; Fiscal Year: 2012
    ....
  37. Exploiting Fatty Acid Metabolism To Cure Malaria
    DAVID ARMAND FIDOCK; Fiscal Year: 2013
    ..Most currently available antimalarials target the symptomatic blood stage parasites rather than the initial asymptomatic liver stage, while many ..
  38. Genome Surveillance for drug resistant malaria
    Dyann F Wirth; Fiscal Year: 2010
    ..abstract_text> ..
  39. Target-Based High-Throughput Screens for Plasmodium falciparum Malaria
    Jon Clardy; Fiscal Year: 2010
    ..Here we will develop a new target-based assay to screen structurally diverse small molecule libraries to identify new antimalarial agents to kill the parasite. ..
  40. Discovery of Marine Invertebrate-Derived Antimalarial Agents
    Amy E Wright; Fiscal Year: 2013
    ....
  41. Within Host Selection of P. falciparum Variants by Artemisinin Combination Therap
    JONATHAN JAMES JULIANO; Fiscal Year: 2013
    ..measure, within individual hosts, the true diversity of falciparum infections and the selective pressure of antimalarials. Specifically, we will: i) sequence and quantitate merozoite surface protein-2 (msp2) genotypes within ..
  42. Dual Function Acridones as A New Antimalarial Chemotype
    Jane X Kelly; Fiscal Year: 2010
    ..g., respiratory inhibitors and anti-folates), development of drug resistance to quinoline antimalarials has been slow (e.g., chloroquine) or of low order (e.g.,quinine)...
  43. Genome-wide studies to identify markers of artemisinin-resistant malaria
    SHANNON TAKALA HARRISON; Fiscal Year: 2013
    ....
  44. Prenyl Synthase Inhibitors: Novel Anti-Infective Agents
    Eric Oldfield; Fiscal Year: 2013
    ..Focus will be on developing inhibitors for three unique targets in malaria parasites, and on the use of novel drugs against sleeping sickness. ..
  45. Identification of Erythrocyte Beta-adrenergic and Gs-mediated Pathways
    Sebastian Fernandez-Pol; Fiscal Year: 2011
    ..Knowledge concerning malaria invasion may result in the identification of drug targets and subsequent development of antimalarials, thus leading to reduced human suffering from this devastating parasite.
  46. Aspartic Protease Inhibitors as Novel Antimalarials
    Marvin J Meyers; Fiscal Year: 2013
    ..In order to efficiently address the critical need for novel antimalarials, the Center for World Health &Medicine (CWHM) at Saint Louis University has established a research ..
  47. Mechanism of malaria parasite egress from erythrocytes
    May M Paing; Fiscal Year: 2010
    ..Understanding the biology of this important step in infection will provide new strategies for treatment of malaria and development of anti-malarial vaccine. ..
  48. Essential PK/PD Relationships of Antimalarial and Antitrypanosomal Drugs
    Theresa A Shapiro; Fiscal Year: 2013
    ..In Aim 1 this new system will be used to describe the essential PK/PDs for selected antimalarials, to determine whether these relationships are class-wide, if they correlate with those for bacteria, and how ..
  49. Drugs targeting erythrocytic and exoerythrocytic stages of malaria
    Roman Manetsch; Fiscal Year: 2013
    ..The three chemotypes possess in vivo liver stage activity, in vivo blood stage activity, gametocytocidal activity, and/or activity in the mosquitoes. ..
  50. Forward genetic screens for identifying antimalarial resistance genes
    Manoj T Duraisingh; Fiscal Year: 2010
    ..knowlesi and P. falciparum parasites, and screened for genes that confer resistance to specific antimalarials. Our system is a novel approach in malaria biology that will have broad application, simultaneously ..
  51. Genomic Analyses of Plasmodium vivax Responses to Antimalarial Drugs in Cambodia
    David Serre; Fiscal Year: 2013
    ..vivax. Our findings will improve our understanding of drug resistance in this neglected human malaria parasite and have the potential to significantly advance vivax malaria control. ..
  52. Determine high-resolution structure of membrane protein by single particle cryoEM
    Yifan Cheng; Fiscal Year: 2013
    ..The PfCRT plays a critical role in Plasmodium falciparum resistance to the quinoline antimalarials. We aim to determine the structure of these two proteins to subnanometer resolution and eventually to near ..
  53. Population biology of malaria drug resistance in Yunnan
    Zhaoqing Yang; Fiscal Year: 2010
    ..parasite populations, we propose to (1) systematically evaluate parasite's sensitivity to a wide range of antimalarials;and (2) determine the polymorphisms in known and putative molecular markers of drug targets and evaluate their ..
  54. Chemical Genomics for Antimalarial Targets
    Pradipsinh K Rathod; Fiscal Year: 2013
    ..The search for new novel antimalarials relies on a number of approaches including natural products, high-throughput screens, small chemical libraries ..
  55. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2003
    ..Such selection could accelerate the development of Plasmodium falciparum resistance to PS and other antifolate antimalarials in areas where HIV infection and malaria are both highly prevalent...
  56. The spatial organization of the Plasmodium genome throughout its infectious cycle
    William Stafford Noble; Fiscal Year: 2013
    ..By providing fundamental insight into the regulatory mechanisms of the malaria parasite, this project will improve our ability to design new drugs and novel lines of defense against malaria. ..
  57. Molecular Pathways Targeted by Potent Antimalarial Pyrazole Compounds
    Akhil B Vaidya; Fiscal Year: 2013
    ..Antimalarial drugs are the mainstay of malaria control, but the spread of parasite resistance to most antimalarials is of grave concern...
  58. Deciphering apicoplast function during blood stage Plasmodium infection
    Ellen Yeh; Fiscal Year: 2013
    ..In the face of developing resistance against the current last-line therapy, new antimalarials are desperately needed and a greater understanding of Plasmodium biology will be required to identify viable ..
  59. Genetic Variation and Evolution of Artemisinin Resistance
    Dyann F Wirth; Fiscal Year: 2013
    ..Because the emergence of drug resistance threatens to outpace the development of effective new antimalarial drugs, the development of an early warning system for emerging resistance is an essential component to defeating malaria. ..
  60. Optimizing ELQs for Treatment and Prevention of Malaria
    MICHAEL KEVIN RISCOE; Fiscal Year: 2012
    ..objective of our proposed work is the development of an inexpensive ELQ that can be co-formulated with other antimalarials in a synergistic combination to prevent and treat malaria, and can serve to assist in eradication of the ..
  61. Azithromycin Combination Therapy in Resistant Malaria
    Charles Knirsch; Fiscal Year: 2000
    ..abstract_text> ..
  62. Preventing Pregnancy Malaria: Maternal-Infant Outcomes
    Michal Fried; Fiscal Year: 2009
    ..We will also establish a center of excellence for future research on antimalarial interventions in Tanzania. ..
  63. AZITHROMYCIN TREATMENT FOR DRUG-RESISTANT MALARIA
    Jonathan Berman; Fiscal Year: 2000
    ..4. Test the hypothesis that the best two azithromycin combinations are similarly efficacious in children and pregnant women (assess efficacy and safety in special populations). ..
  64. IMPACT OF TS PROPHYLAXIS ON ANTIFOLATE RESISTANT MALARIA
    James Kublin; Fiscal Year: 2000
    ..falciparum. Such selection could accelerate the development of Plasmodium falciparum resistance to antifolate antimalarials in areas where HIV infection and malaria are both highly prevalent...
  65. Preclinical Studies of Natural Product Derivatives as Antimalarial Agents
    Shuren Zhu; Fiscal Year: 2012
    ..falciparum malaria. The novelty of the research is the discovery of new molecular entities. The multidisciplinary team and multi-institution collaboration that has been assembled will accelerate the generation of clinical candidates. ..
  66. Membrane Permeable Diphosphate Analogs Targeting Pathogen Isoprenoid Biosynthesis
    CAREN L MEYERS; Fiscal Year: 2013
    ..These studies will provide a foundation for the transformation of highly polar, potent inhibitors of isoprenoid biosynthesis into useful therapeutic agents for the treatment of infectious diseases. ..
  67. Structural Basis for Isoprenoid Biosynthesis
    JOSEPH NOEL; Fiscal Year: 2006
    ....
  68. Falciparum malaria invasion ligand DNA/protein vaccine
    David Narum; Fiscal Year: 2002
    ..S. military has lost more person days to malaria than to bullets (Beadle and Hoffman, 1993). A vaccine against malaria would have enormous domestic and international commercial value. ..
  69. Indirect aminoacylation in the Plasmodium apicoplast
    MALCOLM JOHN GARDNER; Fiscal Year: 2010
    ..This research program will characterize a novel Plasmodium biochemical pathway that we believe is essential to parasite survival and therefore a potential target for drug therapy of malaria. ..
  70. SP resistance markers & falciparum malaria transmission
    Fabian Mendez; Fiscal Year: 2004
    ..abstract_text> ..
  71. 7th International Congress on Toxoplasmosis
    Kami Kim; Fiscal Year: 2003
    ..a model organism for studies on all of the Apicomplexa as was highlighted in a recent review on development of antimalarials by Robert Ridley (Nature 2002 Feb 7;415(6872):686-93)...
  72. PRIMAQUINE-INDUCED HEMOLYTIC ANEMIA
    DAVID MC MILLAN; Fiscal Year: 2004
    ....
  73. DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2002
    ..abstract_text> ..
  74. Molecular determinants of P. falciparum resistance to ACTs in Nigeria.
    Christian T Happi; Fiscal Year: 2010
    ..Molecular determinants of parasites responses to antimalarials identified under this project will be used to develop a quick and simple high-throughput PCR-ELISA based tool/..
  75. New Antimalarials from Plant-Pathogenic Fungi
    NP NANAYAKKARA; Fiscal Year: 2005
    ..The purpose of this proposal is to expand on these results and to identify antimalarial compounds from plant pathogenic fungi and their preliminary evaluation as new clinically useful antimalarial agents. ..
  76. Clinical trial of chloroquine combinations in Malawi
    CHRISTOPHER PLOWE; Fiscal Year: 2009
    ..No further delays are anticipated and this extension will permit completion of this ongoing unique and important clinical trial. ..
  77. Synthesis and Evaluation of Novel Antimalarial Agents
    Shuren Zhu; Fiscal Year: 2005
    ..An investigational new drug (IND) application will then be filed with FDA. ..
  78. Institutional Collaboration Between Liverpool STM & CDC on Malaria
    Feiko ter Kuile; Fiscal Year: 2009
    ..of the interaction between HIV and malaria to a) determine the potential for drug-drug interactions between antimalarials, ARVs and cotrimoxazole prophylaxis in HIV-infected non-pregnant and pregnant individuals in sub-Saharan ..