anthelmintics

Summary

Summary: Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.

Top Publications

  1. ncbi Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm
    Jeffrey Bethony
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC, 20037, USA
    Lancet 367:1521-32. 2006
  2. ncbi Human schistosomiasis
    Bruno Gryseels
    Institute for Tropical Medicine Antwerp, Nationalestraat 155 B 2000, Antwerp, Belgium
    Lancet 368:1106-18. 2006
  3. ncbi Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, PO Box, CH 4002 Basel, Switzerland
    JAMA 299:1937-48. 2008
  4. pmc Diagnosis of soil-transmitted helminths in the era of preventive chemotherapy: effect of multiple stool sampling and use of different diagnostic techniques
    Stefanie Knopp
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    PLoS Negl Trop Dis 2:e331. 2008
  5. ncbi Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis
    Michael J Doenhoff
    School of Biology, University of Nottingham, University Park, Nottingham, UK
    Curr Opin Infect Dis 21:659-67. 2008
  6. ncbi Drug resistance in veterinary helminths
    Adrian J Wolstenholme
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    Trends Parasitol 20:469-76. 2004
  7. pmc A research agenda for helminth diseases of humans: intervention for control and elimination
    Roger K Prichard
    Institute of Parasitology, McGill University, Montreal, Canada
    PLoS Negl Trop Dis 6:e1549. 2012
  8. pmc Assessment of the anthelmintic efficacy of albendazole in school children in seven countries where soil-transmitted helminths are endemic
    Jozef Vercruysse
    Department of Virology, Parasitology and Immunology, Ghent University, Faculty of Veterinary Medicine, Merelbeke, Belgium
    PLoS Negl Trop Dis 5:e948. 2011
  9. pmc Performance and safety of praziquantel for treatment of intestinal schistosomiasis in infants and preschool children
    José C Sousa-Figueiredo
    Disease Control Strategy Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS Negl Trop Dis 6:e1864. 2012
  10. ncbi The drugs we have and the drugs we need against major helminth infections
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Adv Parasitol 73:197-230. 2010

Detail Information

Publications335 found, 100 shown here

  1. ncbi Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm
    Jeffrey Bethony
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC, 20037, USA
    Lancet 367:1521-32. 2006
    ..The benzimidazole anthelmintics, mebendazole and albendazole, are commonly used to remove these infections...
  2. ncbi Human schistosomiasis
    Bruno Gryseels
    Institute for Tropical Medicine Antwerp, Nationalestraat 155 B 2000, Antwerp, Belgium
    Lancet 368:1106-18. 2006
    ..Vaccines are not yet available. Great advances have been made in the control of the disease through population-based chemotherapy but these required political commitment and strong health systems...
  3. ncbi Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, PO Box, CH 4002 Basel, Switzerland
    JAMA 299:1937-48. 2008
    ..Preventive chemotherapy is the mainstay of control, but only 4 drugs are available: albendazole, mebendazole, levamisole, and pyrantel pamoate...
  4. pmc Diagnosis of soil-transmitted helminths in the era of preventive chemotherapy: effect of multiple stool sampling and use of different diagnostic techniques
    Stefanie Knopp
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    PLoS Negl Trop Dis 2:e331. 2008
    ..In this study, we focused on schoolchildren on Unguja Island, Zanzibar, an area where anthelminthic drugs have been repeatedly administered over the past decade...
  5. ncbi Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis
    Michael J Doenhoff
    School of Biology, University of Nottingham, University Park, Nottingham, UK
    Curr Opin Infect Dis 21:659-67. 2008
    ....
  6. ncbi Drug resistance in veterinary helminths
    Adrian J Wolstenholme
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    Trends Parasitol 20:469-76. 2004
    ..Resistance to anthelmintics has become a major problem in veterinary medicine, and threatens both agricultural income and animal welfare...
  7. pmc A research agenda for helminth diseases of humans: intervention for control and elimination
    Roger K Prichard
    Institute of Parasitology, McGill University, Montreal, Canada
    PLoS Negl Trop Dis 6:e1549. 2012
    ..The continuation of prolonged MDA with a limited number of anthelmintics greatly increases the probability that drug resistance will develop, which would raise serious problems for ..
  8. pmc Assessment of the anthelmintic efficacy of albendazole in school children in seven countries where soil-transmitted helminths are endemic
    Jozef Vercruysse
    Department of Virology, Parasitology and Immunology, Ghent University, Faculty of Veterinary Medicine, Merelbeke, Belgium
    PLoS Negl Trop Dis 5:e948. 2011
    ..The objective of this study, therefore, was to define the efficacy of a single 400 milligram dose of albendazole (ALB) against these three STH using a standardized protocol...
  9. pmc Performance and safety of praziquantel for treatment of intestinal schistosomiasis in infants and preschool children
    José C Sousa-Figueiredo
    Disease Control Strategy Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS Negl Trop Dis 6:e1864. 2012
    ..We have formally assessed parasitological cure and putative side-effects in a prospective cohort of Schistosoma mansoni-infected children (aged 5 months-7 years old) in lakeshore settings of Uganda...
  10. ncbi The drugs we have and the drugs we need against major helminth infections
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Adv Parasitol 73:197-230. 2010
    ..Issuing from our review are current research gaps and the need for concerted efforts to discover, develop and deploy the next generation of anthelminthic drugs...
  11. ncbi Albendazole and mebendazole administered alone or in combination with ivermectin against Trichuris trichiura: a randomized controlled trial
    Stefanie Knopp
    Departments of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Clin Infect Dis 51:1420-8. 2010
    ..Single-dose albendazole and mebendazole show limited efficacy in the treatment of trichuriasis. The combination of albendazole with ivermectin improves efficacy, but a mebendazole-ivermectin combination has not been previously investigated...
  12. pmc Strategies and tools for the control/elimination of lymphatic filariasis
    E A Ottesen
    Division of Control of Tropical Diseases, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 75:491-503. 1997
    ....
  13. ncbi The global epidemiological situation of schistosomiasis and new approaches to control and research
    D Engels
    Parasitic Diseases and Vector Control, Communicable Diseases Control, Prevention and Eradication, World Health Organization, CH 1211 27, Geneva, Switzerland
    Acta Trop 82:139-46. 2002
    ..Related to this new vision, some research needs are pointed out...
  14. pmc Low efficacy of single-dose albendazole and mebendazole against hookworm and effect on concomitant helminth infection in Lao PDR
    Phonepasong Ayé Soukhathammavong
    National Institute of Public Health, Ministry of Health, Vientiane, Lao People s Democratic Republic
    PLoS Negl Trop Dis 6:e1417. 2012
    ..Since Opisthorchis viverrini is co-endemic in our study setting, the effect of the two drugs could also be determined against this liver fluke...
  15. ncbi Nutritional impact of intestinal helminthiasis during the human life cycle
    D W T Crompton
    WHO Collaborating Centre for Soil Transmitted Helminthiasis, Graham Kerr Building, University of Glasgow, Glasgow, G12 8QQ, Scotland
    Annu Rev Nutr 22:35-59. 2002
    ..Cost-effective measures based on highly efficacious anthelminthic drugs are now available to reduce and control disease caused by these infections...
  16. pmc Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: a systematic review
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    PLoS Negl Trop Dis 5:e1321. 2011
    ..In a systematic review of published studies, we examined evidence for incremental benefits from repeated praziquantel dosing, given 2 to 8 weeks after an initial dose, in Schistosoma-endemic areas of Africa...
  17. pmc Impact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: a double-blind placebo-controlled randomized trial
    Patrick Kirwan
    Department of Zoology, University of Dublin, Trinity College, Dublin 2, Ireland
    BMC Infect Dis 10:277. 2010
    ..Helminth infections can alter susceptibility to malaria. Studies need to determine whether or not deworming programs can impact on Plasmodium infections in preschool children...
  18. pmc In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections
    Lucienne Tritten
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e1457. 2011
    ..In the present work, we tested the efficacy of the veterinary drug monepantel, a potential drug development candidate compared to standard drugs in vitro and in parasite-rodent models of relevance to human soil-transmitted helminthiases...
  19. ncbi Exploration of novel in vitro assays to study drugs against Trichuris spp
    Angelika Silbereisen
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Socinstr 57, 4002 Basel, Switzerland
    J Microbiol Methods 87:169-75. 2011
    ..In conclusion, the colorimetric Alamar Blue in vitro assay is a good alternative to the motility assay to study drug effects against T. muris L4 and adults, since it is easy to perform, precise and of low cost...
  20. pmc Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren
    Narcis B Kabatereine
    Vector Control Division, Ministry of Health, Kampala, Uganda
    Bull World Health Organ 85:91-9. 2007
    ..We aimed to assess the health impact of a national control programme targeting schistosomiasis and intestinal nematodes in Uganda, which has provided population-based anthelmintic chemotherapy since 2003...
  21. ncbi Preventive chemotherapy in human helminthiasis: theoretical and operational aspects
    A F Gabrielli
    Department of Control of Neglected Tropical Diseases NTD, World Health Organization, Geneva, Switzerland
    Trans R Soc Trop Med Hyg 105:683-93. 2011
    ....
  22. ncbi Relative contribution of day-to-day and intra-specimen variation in faecal egg counts of Schistosoma mansoni before and after treatment with praziquantel
    J Utzinger
    Swiss Tropical Institute, Basel
    Parasitology 122:537-44. 2001
    ..We conclude that diagnostic sensitivity in high transmission areas is maximized by making several stool readings on several days, but examining 1 stool specimen several times can make reasonable estimates of infection intensity...
  23. ncbi Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection
    J Gardon
    Antenne ORSTOM auprès du Centre Pasteur, Yaounde, Cameroon
    Lancet 350:18-22. 1997
    ..We assessed the incidence of serious events in an area where onchocerciasis and loiasis are both endemic...
  24. ncbi Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren
    Anita H J van den Biggelaar
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Infect Dis 189:892-900. 2004
    ..To show a direct link, prospective intervention studies are required...
  25. pmc Highlights of human toxocariasis
    J F Magnaval
    Service de Parasitologie, Centre Hospitalier Universitaire Rangueil 31403 Toulouse 4, France
    Korean J Parasitol 39:1-11. 2001
    ..use, when visceral larva migrans and few cases of common or covert toxocariasis can be treated by anthelmintics whose the most efficient appeared to be diethylcarbamazine...
  26. pmc Impact of hookworm infection and deworming on anaemia in non-pregnant populations: a systematic review
    Jennifer L Smith
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    Trop Med Int Health 15:776-95. 2010
    ....
  27. pmc Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening
    Maha Hamadien Abdulla
    Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences QB3, University of California, San Francisco, California, United States of America
    PLoS Negl Trop Dis 3:e478. 2009
    ....
  28. ncbi From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis
    Jurg Utzinger
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, PO Box, CH 4002 Basel, Switzerland
    Acta Trop 120:S121-37. 2011
    ..We discuss unresolved issues and emerging opportunities for integrated and sustainable control of schistosomiasis and conclude with a series of research needs...
  29. ncbi Unresolved issues in anthelmintic pharmacology for helminthiases of humans
    Timothy G Geary
    Institute of Parasitology, McGill University, Montreal, QC, Canada H9X 3V9
    Int J Parasitol 40:1-13. 2010
    ..Despite decades of clinical experience with anthelmintics for the treatment of human infections, relatively little is known about their clinical pharmacology...
  30. pmc Schistosomiasis in African infants and preschool children: let them now be treated!
    J Russell Stothard
    Parasitology Department, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    Trends Parasitol 29:197-205. 2013
    ....
  31. ncbi Clinical features and evolution of alveolar echinococcosis in France from 1982 to 2007: results of a survey in 387 patients
    Martine Piarroux
    Thema, UMR CNRS 6049, Universite de Franche Comte, 25030 Besancon, France
    J Hepatol 55:1025-33. 2011
    ..Alveolar echinococcosis (AE) is a rare disease in humans, caused by the larval stage of the fox tapeworm Echinococcus multilocularis...
  32. ncbi An account of the botanical anthelmintics used in traditional veterinary practices in Sahiwal district of Punjab, Pakistan
    Altaf Hussain
    Department of Veterinary Parasitology, University of Agriculture, Faisalabad 38040, Pakistan
    J Ethnopharmacol 119:185-90. 2008
    The present study was aimed at documentation of botanical anthelmintics used in the traditional veterinary practices in Sahiwal district of Punjab, Pakistan.
  33. pmc Increases in levels of schistosome-specific immunoglobulin E and CD23(+) B cells in a cohort of Kenyan children undergoing repeated treatment and reinfection with Schistosoma mansoni
    Carla L Black
    Center for Tropical and Emerging Global Diseases and Department of Microbiology, University of Georgia, Athens, Georgia 30602 3799, USA
    J Infect Dis 202:399-405. 2010
    ....
  34. ncbi Sex- and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment
    Livia Pica-Mattoccia
    Institute of Cell Biology, CNR, 32 Via Ramarini, 00016 Monterotondo, Rome, Italy
    Int J Parasitol 34:527-33. 2004
    ..In these instances, however, worms resumed movements and normal shape upon drug removal and were able to survive. The inference of these observations on the clinical use of praziquantel and on its mechanism of action is discussed...
  35. ncbi Use of circulating cathodic antigen strips for the diagnosis of urinary schistosomiasis
    N Midzi
    National Institute of Health Research, Harare, Zimbabwe
    Trans R Soc Trop Med Hyg 103:45-51. 2009
    ..2% and 95.8%, respectively, for pre- and post-treatment results. The improved version that is field applicable now has an acceptable role in the field diagnosis of S. haematobium...
  36. pmc Soil-transmitted helminth reinfection after drug treatment: a systematic review and meta-analysis
    Tie Wu Jia
    Key Laboratory on Biology of Parasites and Vectors, MOH, WHO Collaborating Center on Malaria, Schistosomiasis and Filariasis, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, People s Republic of China
    PLoS Negl Trop Dis 6:e1621. 2012
    ..This strategy, however, does not prevent reinfection. We performed a systematic review and meta-analysis to assess patterns and dynamics of STH reinfection after drug treatment...
  37. ncbi Hookworm infection
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    N Engl J Med 351:799-807. 2004
  38. pmc A 5-year longitudinal study of schistosomiasis transmission in Shian village, the Anning River Valley, Sichuan Province, the Peoples' Republic of China
    Rong Zhu
    National Institute of Parasitic Disease, Chinese Centre for Disease Control and Prevention, Shanghai, PR China
    Parasit Vectors 4:43. 2011
    ..Here we present the results from a schistosomiasis-endemic village located above the dam in Sichuan Province...
  39. ncbi Control of onchocerciasis in Africa: threshold shifts, breakpoints and rules for elimination
    Hans P Duerr
    Dept of Medical Biometry, University of Tuebingen, Westbahnhofstrasse 55, 72070 Tuebingen, Germany
    Int J Parasitol 41:581-9. 2011
    ....
  40. ncbi The impact of baseline faecal egg counts on the efficacy of single-dose albendazole against Trichuris trichiura
    B Levecke
    Department of Virology, Parasitology and Immunology, Ghent University, Faculty of Veterinary Medicine, Merelbeke, Belgium
    Trans R Soc Trop Med Hyg 106:128-30. 2012
    ..0001) when mean baseline FECs increased, highlighting that this parameter should be considered as an important confounding factor for drug efficacy...
  41. ncbi Lymphatic filariasis: Treatment, control and elimination
    Eric A Ottesen
    Lymphatic Filariasis Support Centre, The Task Force for Child Survival and Development, 750 Commerce Drive Decatur, GA 30030, USA
    Adv Parasitol 61:395-441. 2006
    ....
  42. pmc Closing the praziquantel treatment gap: new steps in epidemiological monitoring and control of schistosomiasis in African infants and preschool-aged children
    J Russell Stothard
    Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, SW7 5BD, UK
    Parasitology 138:1593-606. 2011
    ..mansoni appears to diminish after repeated rounds of treatment. Thus use of PZQ should be combined with appropriate health education/water hygiene improvements for both child and mother to bring forth a more enduring solution...
  43. pmc Intestinal schistosomiasis in mothers and young children in Uganda: investigation of field-applicable markers of bowel morbidity
    Martha Betson
    Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, United Kingdom
    Am J Trop Med Hyg 83:1048-55. 2010
    ..0001) and mothers (n = 448, OR = 1.95, P = 0.004). Fecal occult blood appears to be useful for measuring morbidity associated with intestinal schistosomiasis and could be used in assessing the impact of control programs upon disease...
  44. ncbi The detection of anthelmintic resistance in nematodes of veterinary importance
    G C Coles
    Department of Clinical Veterinary Science, University of Bristol, Langford House, UK
    Vet Parasitol 136:167-85. 2006
    ..of the faecal egg count reduction test has been modified and suggestions given on its use with persistent anthelmintics and continuous release devices. An egg hatch test for benzimidazole (BZ) resistance is described...
  45. pmc Assays to detect beta-tubulin codon 200 polymorphism in Trichuris trichiura and Ascaris lumbricoides
    Aissatou Diawara
    Institute of Parasitology, McGill University, Quebec, Canada
    PLoS Negl Trop Dis 3:e397. 2009
    ..Unfortunately, there is concern that increased use of anthelmintics could select for resistant populations of these human parasites...
  46. ncbi Efficacy and side effects of praziquantel treatment in a highly endemic Schistosoma mansoni focus at Lake Albert, Uganda
    N B Kabatereine
    Vector Control Division, Ministry of Health, Kampala, Uganda
    Trans R Soc Trop Med Hyg 97:599-603. 2003
    ..The marked reductions in faecal egg excretion and the acceptable level of side effects point to a single praziquantel treatment (40mg/kg) as the strategy of choice in such a highly endemic S. mansoni focus...
  47. pmc Does treatment of intestinal helminth infections influence malaria? Background and methodology of a longitudinal study of clinical, parasitological and immunological parameters in Nangapanda, Flores, Indonesia (ImmunoSPIN Study)
    Aprilianto E Wiria
    Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
    BMC Infect Dis 10:77. 2010
    ..Different cross-sectional studies using diverse methodologies have reported that helminth infections might either exacerbate or reduce the severity of malaria attacks. The same discrepancies have been reported for parasitemia...
  48. ncbi Clinical features and treatment of alveolar echinococcosis
    Peter Kern
    Division of Infectious Diseases and Clinical Immunology, Comprehensive Infectious Diseases Center, University Hospitals, Ulm, Germany
    Curr Opin Infect Dis 23:505-12. 2010
    ..The present review summarizes current understanding of clinical features, knowledge on appropriate treatment, and discusses ways to improve standards of care...
  49. pmc Effect of single-dose anthelmintic treatment during pregnancy on an infant's response to immunisation and on susceptibility to infectious diseases in infancy: a randomised, double-blind, placebo-controlled trial
    Emily L Webb
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 377:52-62. 2011
    ..Helminth infections affect the human immune response. We investigated whether prenatal exposure to and treatment of maternal helminth infections affects development of an infant's immune response to immunisations and unrelated infections...
  50. pmc Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution
    J Utzinger
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Parasitology 136:1859-74. 2009
    ..Consequently, besides the environment, the prevailing demographic, health and social systems contexts need to be considered...
  51. pmc The impact of repeated rounds of mass drug administration with diethylcarbamazine plus albendazole on bancroftian filariasis in Papua New Guinea
    Gary J Weil
    Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Negl Trop Dis 2:e344. 2008
    ..This study employed various monitoring methods to assess the impact of repeated rounds of mass drug administration (MDA) on bancroftian filariasis in Papua New Guinea, which has the largest filariasis problem in the Pacific region...
  52. pmc Two-year impact of single praziquantel treatment on infection in the national control programme on schistosomiasis in Burkina Faso
    Seydou Toure
    Programme National de Lutte contre la Schistosomiase et les Vers Intestinaux, Ministere de la Sante, Ouagadougou, Burkina Faso
    Bull World Health Organ 86:780-7, A. 2008
    ....
  53. pmc Spinal hydatid disease: a case series
    Mukund M Prabhakar
    Department of Orthopedics, B J Medical College and Civil Hospital, Ahmedabad, India
    J Spinal Cord Med 28:426-31. 2005
    ..Hydatid disease of the spine is a rare condition with a poor prognosis that presents diagnostic and therapeutic challenges...
  54. ncbi Intradural extramedullary spinal hydatidosis: case report
    A Kaen
    Hospital 12 de Octubre Madrid Spain
    Neurocirugia (Astur) 20:282-7. 2009
    ..We report a case of recurrent hydatid disease that presented unusual intradural dissemination. Prognosis for spinal hydatid disease remains very poor and comparable to that of a malignant neoplasm...
  55. ncbi Increases in human T helper 2 cytokine responses to Schistosoma mansoni worm and worm-tegument antigens are induced by treatment with praziquantel
    Sarah Joseph
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Infect Dis 190:835-42. 2004
    ..The changes in cytokines were not strongly influenced by age or intensity of infection and were not accompanied by corresponding increases in the numbers of circulating eosinophils or lymphocytes...
  56. ncbi Role of vector control in the global program to eliminate lymphatic filariasis
    Moses J Bockarie
    Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, United Kingdom
    Annu Rev Entomol 54:469-87. 2009
    ....
  57. pmc Efficacy and safety of praziquantel in preschool-aged children in an area co-endemic for Schistosoma mansoni and S. haematobium
    Jean T Coulibaly
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 6:e1917. 2012
    ..Since a pediatric formulation (e.g., syrup) is not available outside of Egypt, crushed praziquantel tablets are used, but the efficacy and safety of this treatment regimen is insufficiently studied...
  58. ncbi Efficacy and side effects of praziquantel treatment against Schistosoma haematobium infection among primary school children in Zimbabwe
    N Midzi
    National Institute of Health Research, Box CY 573, Causeway, Harare, Zimbabwe
    Trans R Soc Trop Med Hyg 102:759-66. 2008
    ..The parasitological cure rate was not associated with gender or age. Our study demonstrates that praziquantel is efficacious against S. haematobium in Zimbabwe, although low levels of persistent infection warrant further investigation...
  59. pmc Effect of combinations of marketed human anthelmintic drugs against Trichuris muris in vitro and in vivo
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P O Box, CH 4002 Basel, Switzerland
    Parasit Vectors 5:292. 2012
    ..The discovery and development of novel efficacious drugs or drug combinations for the treatment of STH infections therefore has a high research priority...
  60. ncbi Patterns of intestinal schistosomiasis among mothers and young children from Lake Albert, Uganda: water contact and social networks inferred from wearable global positioning system dataloggers
    Edmund Y W Seto
    School of Public Health, University of California, Berkeley, CA 94720, United States of America
    Geospat Health 7:1-13. 2012
    ..We believe that this should now be formally considered within NCP, which may benefit from more in-depth ethnographic exploration of factors related to water contact as this should provide new opportunities for sustaining control...
  61. ncbi Candidate anthelmintic resistance-associated gene expression and sequence polymorphisms in a triple-resistant field isolate of Haemonchus contortus
    Sally M Williamson
    Dept of Infectious Diseases, University of Georgia, Athens, GA 30602, USA
    Mol Biochem Parasitol 180:99-105. 2011
    ....
  62. ncbi Benefit of vitamin A supplementation on ascaris reinfection is less evident in stunted children
    Leslie G Payne
    School of Dietetics and Human Nutrition and 4Institute of Parasitology, McGill University Macdonald Campus, Quebec, Canada
    J Nutr 137:1455-9. 2007
    ..Our study provides evidence that combined vitamin A supplementation and deworming reduces Ascaris reinfection in children living in areas of chronic parasitosis, but that the duration of the benefit is less in stunted children...
  63. ncbi Mixed infections with Opisthorchis viverrini and intestinal flukes in residents of Vientiane Municipality and Saravane Province in Laos
    J Y Chai
    Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110 799, Korea
    J Helminthol 79:283-9. 2005
    ....
  64. ncbi Macrocyclic lactone resistance in Dirofilaria immitis
    Catherine Bourguinat
    Institute of Parasitology, McGill University, 21111 Lakeshore Road, Sainte Anne de Bellevue, Quebec H9X3V9, Canada
    Vet Parasitol 181:388-92. 2011
    ..3% in microfilariae that survived repeated treatments with high doses of ML anthelmintics. The data show phenotypic and genotypic evidence of ML resistance in Dirofilaria immitis.
  65. ncbi Clinical management of cystic echinococcosis: state of the art, problems, and perspectives
    Thomas Junghanss
    Section of Clinical Tropical Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Am J Trop Med Hyg 79:301-11. 2008
    ..In this paper, we review the current management procedures of CE with particular emphasis on the evidence base and setting-specific problems...
  66. ncbi Actions of the anthelmintic ivermectin on the pharyngeal muscle of the parasitic nematode, Ascaris suum
    D J Brownlee
    Division of Cell Sciences, School of Biological Sciences, University of Southampton, UK
    Parasitology 115:553-61. 1997
    ..Thus interruption of pharyngeal processes such as, feeding, regulation of hydrostatic pressure and secretion may provide a new site of anthelmintic action...
  67. ncbi The epidemiology and control of urinary schistosomiasis and soil-transmitted helminthiasis in schoolchildren on Unguja Island, Zanzibar
    J Russell Stothard
    Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London SW7 5BD, UK
    Trans R Soc Trop Med Hyg 103:1031-44. 2009
    ....
  68. ncbi Efficacy of two cyclooctadepsipeptides, PF1022A and emodepside, against anthelmintic-resistant nematodes in sheep and cattle
    G von Samson-Himmelstjerna
    Institute for Parasitology, Hannover School of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Parasitology 130:343-7. 2005
    Resistance against the major currently available anthelmintics has reached a critical level in many small ruminant herds world-wide, and is increasingly becoming a problem in horses and cattle...
  69. pmc Effects of deworming during pregnancy on maternal and perinatal outcomes in Entebbe, Uganda: a randomized controlled trial
    J Ndibazza
    Medical Research Council Uganda Virus Research Institute Uganda Research Unit on AIDS, Entebbe, Uganda
    Clin Infect Dis 50:531-40. 2010
    ..Deworming during pregnancy has therefore been strongly advocated, but its benefits have not been rigorously evaluated...
  70. ncbi Changing patterns of soil-transmitted helminthiases in Zanzibar in the context of national helminth control programs
    Stefanie Knopp
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 81:1071-8. 2009
    ..To consolidate achievements made, additional control measures such as health education and environmental sanitation are needed...
  71. pmc Immunoglobulin E (IgE) responses to paramyosin predict resistance to reinfection with Schistosoma japonicum and are attenuated by IgG4
    Mario Jiz
    Center for International Health Research, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02901, USA
    Infect Immun 77:2051-8. 2009
    ....
  72. pmc Diagnostic accuracy of Kato-Katz and FLOTAC for assessing anthelmintic drug efficacy
    Stefanie Knopp
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e1036. 2011
    ..We compared the diagnostic accuracy of the Kato-Katz and FLOTAC techniques in the frame of a drug efficacy trial...
  73. pmc Epidemiology of hookworm infection in Kintampo North Municipality, Ghana: patterns of malaria coinfection, anemia, and albendazole treatment failure
    Debbie Humphries
    School of Public Health, Yale University, 60 College Street, New Haven, CT 06520, USA
    Am J Trop Med Hyg 84:792-800. 2011
    ..These data confirm a high prevalence of low-intensity hookworm infection in central Ghana and its association with poor nutritional status. The high rate of albendazole failure raises concern about emerging resistance...
  74. pmc Effects of treatment for intestinal helminth infection on growth and cognitive performance in children: systematic review of randomised trials
    R Dickson
    International Health Division, Liverpool School of Tropical Medicine, Liverpool L3 5QA
    BMJ 320:1697-701. 2000
    ..To summarise the effects of anthelmintic drug treatment on growth and cognitive performance in children...
  75. pmc National mass drug administration costs for lymphatic filariasis elimination
    Ann S Goldman
    Department of Epidemiology, The George Washington School of Public Health and Health Services, Washington, DC, United States of America
    PLoS Negl Trop Dis 1:e67. 2007
    ..3 billion people at risk...
  76. pmc Human infection with Ascaris lumbricoides is associated with suppression of the interleukin-2 response to recombinant cholera toxin B subunit following vaccination with the live oral cholera vaccine CVD 103-HgR
    P J Cooper
    Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 69:1574-80. 2001
    ..The potential modulation of the immune response to oral vaccines by geohelminth parasites has important implications for the design of vaccination campaigns in geohelminth-endemic areas...
  77. pmc Towards an understanding of the mechanism of action of praziquantel
    Anthony D Aragon
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Mol Biochem Parasitol 164:57-65. 2009
    ..mansoni PR-1. Annotation of genes differentially regulated by PZQ exposure suggests that schistosomes may undergo a transcriptomic response similar to that observed during oxidative stress...
  78. ncbi Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics
    A D Dayan
    Parasitic Diseases and Vector Control PVC, Communicable Diseases Control, Prevention and Eradication CPE, World Health Organization, CH 1211 Geneva 27, Switzerland
    Acta Trop 86:141-59. 2003
    ....
  79. ncbi Efficacy of praziquantel against Schistosoma haematobium infection in children
    Louis Albert Tchuem Tchuenté
    Laboratory of General Biology, Faculty of Sciences, University of Yaounde, Yaounde, Cameroon
    Am J Trop Med Hyg 71:778-82. 2004
    ..Since children were in contact with transmission sites during the study period, the results suggest good efficacy of PZQ against all stages of S. haematobium, including the immature worms...
  80. pmc Observed reductions in Schistosoma mansoni transmission from large-scale administration of praziquantel in Uganda: a mathematical modelling study
    Michael D French
    Schistosomiasis Control Initiative, Imperial College London, London, United Kingdom
    PLoS Negl Trop Dis 4:e897. 2010
    ..In doing this we aim to elucidate the benefits of MDA in reducing community transmission...
  81. ncbi Efficacy of praziquantel syrup versus crushed praziquantel tablets in the treatment of intestinal schistosomiasis in Ugandan preschool children, with observation on compliance and safety
    A M D Navaratnam
    Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, UK
    Trans R Soc Trop Med Hyg 106:400-7. 2012
    ..1%) and crushed PZQ tablet (14.7%) arms. PZQ syrup and crushed PZQ tablets have very similar efficacies in the treatment of intestinal schistosomiasis in preschool children...
  82. pmc Multiplex bead assay for serum samples from children in Haiti enrolled in a drug study for the treatment of lymphatic filariasis
    Delynn M Moss
    National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Am J Trop Med Hyg 85:229-37. 2011
    ....
  83. pmc A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motility
    Michael J Smout
    James Cook University, Cairns, Australia
    PLoS Negl Trop Dis 4:e885. 2010
    ..Currently, drug effect is assessed by observing motility or development of parasites using laborious, subjective, low-throughput methods...
  84. pmc Geographical distribution of intestinal schistosomiasis and soil-transmitted helminthiasis and preventive chemotherapy strategies in Sierra Leone
    Joseph B Koroma
    National Onchocerciasis Control Program, Ministry for Health and Sanitation, Freetown, Sierra Leone
    PLoS Negl Trop Dis 4:e891. 2010
    ....
  85. ncbi Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, and praziquantel against Schistosoma haematobium: randomized, exploratory open-label trial
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
    Clin Infect Dis 50:1205-13. 2010
    ..Morbidity control of schistosomiasis relies on a single drug, praziquantel. The antimalarial drug mefloquine possesses interesting antischistosomal properties, yet no clinical studies have been performed...
  86. ncbi Sequential analysis of helminth egg output in human stool samples following albendazole and praziquantel administration
    Alexandra U Scherrer
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Acta Trop 109:226-31. 2009
    ..This is justified on logistical grounds (i.e. collection of stool samples only once) and growing emphasis on integrating the control of schistosomiasis and soil-transmitted helminthiasis, including drug efficacy monitoring...
  87. ncbi Treatment of dog thelaziosis caused by Thelazia callipaeda (Spirurida, Thelaziidae) using a topical formulation of imidacloprid 10% and moxidectin 2.5%
    P Bianciardi
    Vet Parasitol 129:89-93. 2005
    ..5% is very easy to apply and helps overcome problems linked to the mechanical removal of parasites or to the restraining of the animals for the local instillation of drugs in the eyes...
  88. ncbi Monitoring drug efficacy and early detection of drug resistance in human soil-transmitted nematodes: a pressing public health agenda for helminth control
    Marco Albonico
    Fondazione Ivo de Carneri, Via IV Marzo 14, 10122 Torino, Italy
    Int J Parasitol 34:1205-10. 2004
    ..A concerted action with international partners and the creation of a network of scientists to address this issue is the next pressing public health issue for helminth control...
  89. pmc An analysis of genetic diversity and inbreeding in Wuchereria bancrofti: implications for the spread and detection of drug resistance
    Thomas S Churcher
    Department of Infectious Disease Epidemiology, St Mary s Campus, Imperial College London, London, United Kingdom
    PLoS Negl Trop Dis 2:e211. 2008
    ..Helminth genetic differentiation between hosts and non-random mating will also increase the number of hosts (and the number of samples per host) that need to be genotyped, and could enhance the rate of spread of anthelmintic resistance...
  90. pmc New insight into the antifibrotic effects of praziquantel on mice in infection with Schistosoma japonicum
    Yue Jin Liang
    Department of Pathogen Biology, Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China
    PLoS ONE 6:e20247. 2011
    ..For this reason, new strategies and prospective drugs, which exert antifibrotic effects, are urgently required...
  91. ncbi Cure rate is not a valid indicator for assessing drug efficacy and impact of preventive chemotherapy interventions against schistosomiasis and soil-transmitted helminthiasis
    Antonio Montresor
    Department of Control of Neglected Tropical Diseases, World Health Organization, Avenue Appia 20, Geneva, Switzerland
    Trans R Soc Trop Med Hyg 105:361-3. 2011
    ..The present article analyses the peculiarities of helminth infections and those of the drugs used in preventive chemotherapy, explaining the reasons why the cure rate is not an adequate indicator in this specific public health context...
  92. ncbi In vitro and in vivo efficacy of tribendimidine and its metabolites alone and in combination against the hookworms Heligmosomoides bakeri and Ancylostoma ceylanicum
    Lucienne Tritten
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Acta Trop 122:101-7. 2012
    ..19). In conclusion, tribendimidine and dADT show potent anti-hookworm properties. The potential of the promising tribendimidine-levamisole combination should be investigated in greater detail...
  93. ncbi Relationship between increased albendazole systemic exposure and changes in single nucleotide polymorphisms on the β-tubulin isotype 1 encoding gene in Haemonchus contortus
    Virginie Barrère
    Institute of Parasitology, McGill University, Sainte Anne de Bellevue, Quebec, Canada H9X 3V9
    Vet Parasitol 186:344-9. 2012
    Resistance to benzimidazole anthelmintics in the nematode Haemonchus contortus has been correlated with single nucleotide polymorphisms (SNPs) on the β-tubulin isotype 1 gene...
  94. pmc Bacillus thuringiensis Cry5B protein is highly efficacious as a single-dose therapy against an intestinal roundworm infection in mice
    Yan Hu
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California, United States of America
    PLoS Negl Trop Dis 4:e614. 2010
    ..of people to be treated, the threat of parasite resistance, and the inadequacy of current treatments, new anthelmintics are urgently needed...
  95. pmc Are we paying too much attention to cardio-pulmonary nematodes and neglecting old-fashioned worms like Trichuris vulpis?
    Donato Traversa
    Department of Comparative Biomedical Sciences, University of Teramo, Teramo, Italy
    Parasit Vectors 4:32. 2011
    ..This article reviews current knowledge of T. vulpis, together with a discussion of critical points in epidemiology, zoonotic hazard, diagnosis and treatment of canine trichurosis...
  96. pmc Schistosome infection intensity is inversely related to auto-reactive antibody levels
    Francisca Mutapi
    Ashworth Laboratories, School of Biological Sciences, Institute for Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e19149. 2011
    ..The implications of these findings are relevant for understanding both the aetiology of immune disorders mediated by auto-reactive antibodies and in predicting the long-term consequences of large-scale schistosomiasis control programs...
  97. pmc Clinical presentation and management of Fasciola hepatica infection: single-center experience
    Muhsin Kaya
    Department of Gastroenterology, Dicle University School of Medicine, Diyarbakir 21280, Turkey
    World J Gastroenterol 17:4899-904. 2011
    ..To identify the characteristic clinical, laboratory and radiological findings and response to treatment in patients with fascioliasis...
  98. ncbi Geohelminth infection and re-infection after chemotherapy among slum-dwelling children in Durban, South Africa
    C C Appleton
    School of Biological and Conservation Sciences, Westville Campus, University of KwaZulu Natal, Durban 4000, South Africa
    Ann Trop Med Parasitol 103:249-61. 2009
    ..Hookworm infections did not re-appear after treatment. The results show clearly that urban slums should be included in any future helminth-control programmes in South Africa...
  99. ncbi Regression of hepatosplenomegaly in Kenyan school-aged children after praziquantel treatment and three years of greatly reduced exposure to Schistosoma mansoni
    Birgitte J Vennervald
    Danish Bilharziasis Laboratory, Charlottenlund, Denmark
    Trans R Soc Trop Med Hyg 99:150-60. 2005
    ..mansoni, even with continuing exposure to malaria. The lack of complete resolution of hepatosplenomegaly in most children suggests, among other things, a residual organomegaly attributable to malaria...
  100. ncbi A pooled analysis of the efficacy of monepantel, an amino-acetonitrile derivative against gastrointestinal nematodes of sheep
    Barry C Hosking
    Novartis Animal Health Australasia Pty Limited, Yarrandoo R and D Centre, 245 Western Road, Kemps Creek, NSW 2178, Australia
    Parasitol Res 106:529-32. 2010
    Monepantel is the first compound from the amino-acetonitrile derivative class of anthelmintics to be developed for the control of gastrointestinal nematodes of sheep...
  101. ncbi Clinical field study to evaluate the efficacy and safety of the amino-acetonitrile derivative, monepantel, compared with registered anthelmintics against gastrointestinal nematodes of sheep in Australia
    B C Hosking
    Novartis Animal Health Australasia Pty Limited, Yarrandoo R and D Centre, Kemps Creek, New South Wales 2178, Australia
    Aust Vet J 87:455-62. 2009
    To determine the efficacy of monepantel, a developmental compound from the amino-acetonitrile derivative class of anthelmintics, against field infections of gastrointestinal nematodes in sheep.

Research Grants56

  1. Membrane Ion-channels in Helminth Parasites: Anthelmintic Resistance and Sites of
    RICHARD JOHN MARTIN; Fiscal Year: 2011
    ..provided by applicant): 'Membrane Ion-channels in Helminth Parasites: Resistance and Sites of Action for Anthelmintics'The Neglected Tropical Diseases include the Soil-Transmitted Nematode (STN) parasites (ascariasis, ..
  2. X-ray Studies of Sugar-Modifying Enzymes
    Hazel Holden; Fiscal Year: 2013
    ..They are also required for the efficacies of many antibiotics, antifungals, anthelmintics, and antitumor agents. Indeed, the diversity of carbohydrate structures observed in nature is truly remarkable...
  3. Cholinergic Receptors as Targets for Accelerated Anthelmintic Discovery
    MICHAEL JOHN KIMBER; Fiscal Year: 2013
    ..place in the academic laboratories and will show that drugs acting on these receptors have potential as novel anthelmintics. The experiments will combine bioimaging techniques, RNA interference (RNAi), bioassays, physiology and ..
  4. Pharmacological Diversity of nAChRs in Clade III Nematodes: Levamisole receptors
    RICHARD JOHN MARTIN; Fiscal Year: 2013
    ..2. Recently, several novel nematode selective cholinergic anthelmintics, like tribendimidine and derquantel (now synergized with abamectin), have been introduced and increased the ..
  5. Can drug targets from parasitic nematodes be usefully expressed in C. elegans?
    ADRIAN JOHN WOLSTENHOLME; Fiscal Year: 2013
    ..Most anthelmintics target ligand-gated ion channels, such as the ligand-gated ion channels (LGIC)...
  6. Cholinergic receptors on the nematode pharynx: an unexploited drug target
    Alan P Robertson; Fiscal Year: 2012
    ..Control of these nematode parasites relies on an effective supply of anthelmintics. Taking veterinary medicine as an example, we know that continued use of anthelmintic compounds for mass ..
  7. Modulation of levamisole receptors: Pharmacological Diversity of Clade III nAChRs
    RICHARD JOHN MARTIN; Fiscal Year: 2011
    ..2. Recently, several novel nematode selective cholinergic anthelmintics, including tribendimidine and derquantel, have been introduced and increased the significance of cholinergic ..
  8. B. thuringiensis Crystal Proteins as Powerful Next-Generation Anthelmintics
    Raffi V Aroian; Fiscal Year: 2013
    ..Here we propose to develop a new drug we discovered that is made by a natural soil bacterium (which is harmless to humans) and that appears to be a very potent anti-roundworm compound with activity greater than any currently available. ..
  9. A high throughput screen for inhibitors of nematode detoxification genes
    Kevin Strange; Fiscal Year: 2012
    Nematodes parasitize ~25% of the human population. Helminth targeting drugs, or anthelmintics, have been used to control parasitic nematodes for decades and many species are evolving multidrug resistance...
  10. Role of insulin-like signaling in the hookworm infective process
    John M Hawdon; Fiscal Year: 2010
    ..Relevance: Hookworm control is limited to repeated treatment with anthelmintics drugs, which as a long-term strategy suffers from rapid re-infection and the potential for drug resistance...
  11. Microfluidic devices for high-throughput anthelmintic screens
    Shawn R Lockery; Fiscal Year: 2010
    ..Nematode diseases afflict more than a 1/6 of the world's population, yet the anti-nematode drugs - "anthelmintics" - in use today date from the 1960's and 1970's...
  12. Genetic dissection of complex traits in C. elegans
    Leonid Kruglyak; Fiscal Year: 2013
    ..to pathogens, and in the mechanisms of action, resistance, and off-target effects of chemotherapeutics, anthelmintics, pesticides, and other compounds...
  13. Locomotion in Parasitic Nematodes
    RICHARD WALTER KOMUNIECKI; Fiscal Year: 2013
    ..for human health, is the devastating economic impact of parasitic nematodes on livestock and plants, and new anthelmintics and drug targets are both desperately needed in all settings...
  14. Natural and Synthetic Small-Molecule Modulators of Dauer Development in Nematodes
    Rebecca A Butcher; Fiscal Year: 2012
    ..This screen could potentially identify novel anthelmintics. In summary, identifying the dauer pheromone and the food signal and characterizing their mechanism of action ..
  15. GABAERGIC INSECTICIDE TOXICOLOGY
    JOHN CASIDA; Fiscal Year: 2002
    ..activators such as avermectin and moxidectin are also used in ever increasing quantities as insecticides and anthelmintics. More specifically, the goal is to provide toxicological profiles and maps for the insecticide blocker site ..
  16. Neurophysiological and Neuropharmacological Studies of a Parasitic Nematode
    Ralph Davis; Fiscal Year: 2006
    ..applicant): Parasitic nematodes plague the world as major contributors to disease, and anti-parasitic drugs (anthelmintics) are the primary control measure...
  17. Natural and Synthetic Small-Molecule Modulators of Dauer Development in Nematodes
    REBECCA BUTCHER; Fiscal Year: 2009
    ..This screen could potentially identify novel anthelmintics. In summary, identifying the dauer pheromone and the food signal and characterizing their mechanism of action ..
  18. DIAGNOSTICS FOR IVERMECTIN RESISTANCE IN NEMATODES
    Carl Johnson; Fiscal Year: 1992
    DESCRIPTION: (Adapted from the applicant's abstract) Recently, resistance to anthelmintics has emerged as the most important problem confronting the control of parasitic nematodes of ruminants...
  19. DEVELOPMENT OF NUCLEAR RECEPTORS AS ANTHELMINTIC TARGETS
    Ann Sluder; Fiscal Year: 2003
    ..with the functions of NRs essential for nematode viability will provide leads for the development of novel anthelmintics for the control of important human parasitic nematode infections...
  20. NOVEL, NEMATODE-SPECIFIC ANTHELMINTICS AND NEMATICIDES
    Carl Johnson; Fiscal Year: 1990
    The goal of this project is to identify new anthelmintics and/or nematicides, referred to generically as anti-nematode drugs, which have novel modes of action...
  21. Behavioral factors and dietary change in WHTFSMP
    Alok Bhargava; Fiscal Year: 2003
    ..Overall, the results will facilitate the design of policies for improving health of especially minority women in the United States and will be useful for analyses of the Women's Health Initiative data. ..
  22. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2002
    ..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
  23. Domoic Acid and Neonatal Microglia Activation
    Alejandro Mayer; Fiscal Year: 2004
    ..activated microglia cells and their mediators play in DOM-induced excitotoxic neuronal injury and thus contribute to potential novel approaches for the therapy of the neuropathology associated with Amnesic Shellfish Poisoning in humans ..
  24. Natural History of Borrelia lonestari
    Susan Little; Fiscal Year: 2006
    ..S., enhancing public health efforts in those areas where people are risk of infection; reduction in human disease from these pathogens should result. [unreadable] [unreadable] [unreadable] [unreadable]..
  25. Interaction of HIV gp120 & G protein coupled receptors
    Lee Ratner; Fiscal Year: 2007
    ..abstract_text> ..
  26. Ecosystem disturbance and multiscale transmission of a zoonotic wildlife pathogen
    Philip Craig; Fiscal Year: 2007
    ....
  27. Antenatal and preschool iron and zinc use and cognition
    Parul Christian; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  28. MULTIVALENT VACCINE FOR LYMPHATIC FILARIASIS
    Ramaswamy Kalyanasundaram; Fiscal Year: 2010
    ..The proposed studies are based on solid preliminary data and are hypotheses driven. Results from these studies, we believe will advance our knowledge towards developing a defined vaccine against lymphatic filariasis in the human. ..
  29. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..Translation: Ap is an expedient marker to analyze aging effects on ISF-CSF relationships, and the compromised solute clearance by malfunctioning barrier systems. This sheds light on neurodegeneration. ..
  30. HIV1 ASSEMBLY MECHANISM AND INHIBITION
    Lee Ratner; Fiscal Year: 2002
    ..In each case, they will examine the effects on membrane interactions and the structure and expression of extracellular virions, as well as identify the domains in Pr55gag that are critical for regulation by Vif or Vpu. ..
  31. Puberty, Immunity and Malnutrition in S. Japonicum
    Jonathan Kurtis; Fiscal Year: 2005
    ..japonicum including the identification of appropriate antigens, protective isotype and cytokine responses and the modulating effects of host pubertal and nutritional development on these responses. ..
  32. HUMAN POPULATION GROWTH IMPACT ON S. HAEMATOBIUM
    Charles King; Fiscal Year: 2005
    ....
  33. Neural Mechanisms underlying Social Stress
    Michael Watt; Fiscal Year: 2004
    ..Findings from these studies are anticipated to have implications for further understanding the neural bases of maladaptive behaviors arising from either the perception of social stress or inappropriate responding in social situations. ..
  34. HIV/SIV Vpx-Invariant chain Interaction
    Lee Ratner; Fiscal Year: 2004
    ..We will map the domains of SIVmac Vpx that are critical for nuclear localization and li interaction. Mutant SIVmac Vpx selectively missing each activity will then be studied by infection of rhesus macaques. ..
  35. Novel Vaccine Candidates for Falciparum Malaria
    Jonathan Kurtis; Fiscal Year: 2004
    ..Subsequent experiments will evaluate the relationship between humoral and cellular immune recognition of these candidates and resistance to reinfection in the entire cohort of 143 volunteers. ..
  36. Abnormalities of Mitochondria in Chagasic Myocarditis
    Nisha Garg; Fiscal Year: 2003
    ..The proposed studies will determine the pathophysiological contribution of host mitochondrial abnormalities in the progression of chagas disease. ..
  37. APPROACHES TO CHARACTERIZATION OF ANTIINFECTIVE AGENTS
    Mark Hamann; Fiscal Year: 2002
    ..SAR studies will be conducted utilizing chemical and microbial transformations of biologically active secondary metabolites combined with molecular modeling studies. ..
  38. PEPTIDE REGULATION OF THE CHOROID PLEXUS-CSF SYSTEM
    Conrad Johanson; Fiscal Year: 2002
    ..Our long-term goal is to delineate the multifunctional roles of CP in brain fluid homeostasis. ..
  39. CHEMO/ANTIRETROVIRAL THERAPY FOR HTLV1 ATLL
    Lee Ratner; Fiscal Year: 2002
    ..abstract_text> ..
  40. GENETICS OF SEVERE HEPATIC FIBROSIS IN SCHISTOSOMIASIS
    RONALD BLANTON; Fiscal Year: 2001
    ..mansoni as tools for analyzing parasite heterogeneity. This proposal is in response to PA-96-067: Molecular Correlates of Pathogenesis in Parasitic Diseases. ..
  41. HIV VPX/VPR STRUCTURE/FUNCTION
    Lee Ratner; Fiscal Year: 2001
    ..What are the roles of Vpr/x Interactive Cellular Proteins in HIV Infection? a. What is the role of li interaction with Vpx? b. Are there other Vpx- interactive proteins, and do they interact with Vpr? ..
  42. Host Genetics and Symptomatic Dengue Infection
    RONALD BLANTON; Fiscal Year: 2004
    ..The results of this study may help predict populations at risk, may influence vaccine design or may aid in understanding and managing other viral hemorrhagic fevers. ..
  43. Structure Function Analysis of TB Pyrazinamidase
    Ying Zhang; Fiscal Year: 2005
    ..These studies will provide important information about mechanisms of PZA action and resistance and may help design new antituberculosis drugs. ..
  44. TRICHINELLOSIS AND REGULATION OF HOST GENE EXPRESSION
    Douglas Jasmer; Fiscal Year: 2001
    ..Understanding these mechanisms may also contribute unique insight on mechanisms of muscle differentiation and cell cycle regulation in mammalian cells. ..
  45. RESEARCH EXPERIENCE FOR VETERINARY MEDICAL STUDENTS
    Charles Courtney; Fiscal Year: 2006
    ..The UF will provide one additional year of stipend support, with a full year of research support provided by this training grant. If necessary, additional years of support will be provided by the mentor. [unreadable] [unreadable]..
  46. URINARY SCHISTOSOMIASIS: INFECTION AND DISEASE
    Charles King; Fiscal Year: 2004
    ..This information, combined with epidemiological modeling of control strategies, will allow accelerated synthesis of the next generation of control programs. ..
  47. HTLV Receptor Identification and Characterization
    Lee Ratner; Fiscal Year: 2005
    ..Lastly, we will determine if the identified cDNA enhances HTLV-1 envelope binding to murine cell lines, and whether this allows HTLV replication and/or immortalization of murine T cells. ..
  48. Chemo/Antiretroviral therapy for HTLV-1 ATLL
    Lee Ratner; Fiscal Year: 2005
    ..abstract_text> ..
  49. Study of the Strength of CH-Y (Y =O,N)and XH-pi (X=N,O,S) Interactions
    BENJAMIN GUNG; Fiscal Year: 2006
    ..The understanding of these weak interactions is essential for rational drug design and lead optimization. [unreadable] [unreadable]..
  50. ANTIAIDS AGENTS FROM MARINE ORGANISMS
    Mark Hamann; Fiscal Year: 2007
    ....
  51. Development of 13C-retinol isotope dilution techniques
    Sherry Tanumihardjo; Fiscal Year: 2006
    ..abstract_text> ..
  52. Mosquito Immunity to Alphaviruses
    Brian Foy; Fiscal Year: 2006
    ..3) Characterize the mechanisms that Culex tritaeniorhynchus mosquitoes use to clear Sindbis virus-infected midgut cells. [unreadable] [unreadable]..
  53. Innovative Assays for Oncogenic Hedgehog Signaling
    Wei Chen; Fiscal Year: 2008
    ..In particular it should be possible to identify critical proteins modulating altered signaling pathways in pancreatic adenocarcinoma and design pharmacologic strategies to target them for therapeutic benefit. ..
  54. HOST IMMUNOMODULATION BY PARASITES
    Ramaswamy Kalyanasundaram; Fiscal Year: 2004
    ..Overall, the findings from these studies we believe might help improve per-cutaneous vaccination against this disease using defined candidate vaccine antigens against schistosomiasis. ..