Summary: Antibiotics inhibiting the growth of or killing fungi and used in the treatment of various fungal diseases.
Publications213 found, 100 shown here
- In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeastsF Sabatelli
Schering Plough Research Institute, Kenilworth, NJ 07033, USA
Antimicrob Agents Chemother 50:2009-15. 2006..Posaconazole exhibited potent antifungal activity against a wide variety of clinically important fungal pathogens and was frequently more active than other azoles and amphotericin B...
- Antifungal activities of posaconazole, ravuconazole, and voriconazole compared to those of itraconazole and amphotericin B against 239 clinical isolates of Aspergillus spp. and other filamentous fungi: report from SENTRY Antimicrobial Surveillance ProgramM A Pfaller
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
Antimicrob Agents Chemother 46:1032-7. 2002..Surveillance efforts should be expanded in order to monitor the spectrum of filamentous fungal pathogens and their in vitro susceptibility as these new antifungal agents are introduced into clinical use...
- Head-to-head comparison of the activities of currently available antifungal agents against 3,378 Spanish clinical isolates of yeasts and filamentous fungiManuel Cuenca-Estrella
Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo km 2, 28220 Majadahonda Madrid, Spain
Antimicrob Agents Chemother 50:917-21. 2006..Posaconazole and currently available antifungal agents exhibit a potent activity in vitro against the majority of pathogenic fungal species...
- Use of PCR-targeted mutagenesis to disrupt production of fusaricidin-type antifungal antibiotics in Paenibacillus polymyxaJingru Li
Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
Appl Environ Microbiol 73:3480-9. 2007..polymyxa by intergeneric conjugation. Targeted disruption of fusA led to the complete loss of antifungal activity against L. maculans, suggesting that fusA plays an essential role in the nonribosomal synthesis of fusaricidins...
- Paracoccidioides brasiliensis, paracoccidioidomycosis, and antifungal antibioticsG Visbal
Center of Chemistry, Instituto Venezolano de Investigaciones Cientificas IVIC, P O Box 21827, Caracas, Venezuela
Curr Drug Targets Infect Disord 5:211-26. 2005....
- The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanismG Schluckebier
Abbott Laboratories, D46Y AP 10, 100 Abbott Park Road, Abbott Park, IL, 60064, USA
J Mol Biol 289:277-91. 1999..A model for the transition-state based on the atomic details of the active site is consistent with a one-step methyl-transfer mechanism and might serve as a first step towards the design of potent Erm inhibitors...
- Antifungal antibioticsM Gupte
Food and Fermentation Technology Division, University Department of Chemical Technology, Matunga, Mumbai, India
Appl Microbiol Biotechnol 58:46-57. 2002..The present article reviews the current types of antifungal infections, the current scenario of antifungal antibiotics, and the need and approaches to search for newer antifungal antibiotics and antifungal drug targets.
- Paenibacillus polymyxa produces fusaricidin-type antifungal antibiotics active against Leptosphaeria maculans, the causative agent of blackleg disease of canolaPerrin H Beatty
Department of Biological Sciences, University of Alberta, Edmonton, Canada
Can J Microbiol 48:159-69. 2002..These compounds are therefore members of the fusaricidin group of cyclic depsipeptides...
- Mutational analysis of Encephalitozoon cuniculi mRNA cap (guanine-N7) methyltransferase, structure of the enzyme bound to sinefungin, and evidence that cap methyltransferase is the target of sinefungin's antifungal activitySushuang Zheng
Molecular Biology Program, Sloan Kettering Institute, Weill College of Medicine of Cornell University, New York, New York 10021, USA
J Biol Chem 281:35904-13. 2006..We find that the sensitivity of Saccharomyces cerevisiae to growth inhibition by sinefungin is diminished when Abd1 is overexpressed. These results highlight cap methylation as a principal target of the antifungal activity of sinefungin...
- Modulatory effect of cAMP on fungal ergosterol level and inhibitory activity of azole drugsS Sardari
Biomedical Sciences, Fogarty Hall, 41 Lower College Road, University of Rhode Island, Kingston, RI 02881, USA
Can J Microbiol 49:344-9. 2003..The possible significance of this interaction includes potentiation of antifungal activity of drugs by manipulating the cAMP level...
- Comparison of the Sensititre YeastOne colorimetric antifungal panel and Etest with the NCCLS M38-A method to determine the activity of amphotericin B and itraconazole against clinical isolates of Aspergillus sppEstrella Martin-Mazuelos
Servicio de Microbiologia, Hospital Universitario de Valme, Sevilla, Spain
J Antimicrob Chemother 52:365-70. 2003....
- Efficacy of caspofungin alone and in combination with voriconazole in a Guinea pig model of invasive aspergillosisWilliam R Kirkpatrick
Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229 3900, USA
Antimicrob Agents Chemother 46:2564-8. 2002..The combinations of CAS plus VRC were highly effective in this model and should be further evaluated for use against invasive aspergillosis...
- Flow cytometry antifungal susceptibility testing of Aspergillus fumigatus and comparison of mode of action of voriconazole vis-à-vis amphotericin B and itraconazoleRama Ramani
Mycology Laboratory, Wadsworth Center, New York State Department of Health, Albany, New York 12208, USA
Antimicrob Agents Chemother 47:3627-9. 2003..FC results after 4 h correlated well with MICs obtained by the NCCLS M38-A method; voriconazole exhibited fungicidal activity, albeit to a lesser extent than amphotericin B, but to a greater extent than itraconazole...
- [The future of antifungal agents]Shigefumi Maesaki
Rinsho Ketsueki 48:26-35. 2007
- Treatment of intra-abdominal abscesses caused by Candida albicans with antifungal agents and recombinant murine granulocyte colony-stimulating factorAlieke G Vonk
Department of Medicine, Division of General Internal Medicine Department of Pathology, University Medical Center Nijmegen, The Netherlands
Antimicrob Agents Chemother 47:3688-93. 2003..In contrast, addition of rmG-CSF therapy to antifungal treatment might further enhance the beneficial effect of the antifungal agent...
- Amphotericin B-resistant Aspergillus flavus infection successfully treated with caspofungin, a novel antifungal agentTamara Koss
Department of Dermatology, Columbia Presbyterian Medical Center, New York, New York, USA
J Am Acad Dermatol 46:945-7. 2002..Caspofungin shows great promise in the treatment of invasive aspergillosis...
- Susceptibility of clinical isolates of Candida lusitaniae to five systemic antifungal agentsAnne Favel
Laboratoire de Botanique, Cryptogamie et Biologie Cellulaire, Faculte de Pharmacie, 13385 Marseille, France
J Antimicrob Chemother 53:526-9. 2004..The aim of the present study was to expand the MIC database for Candida lusitaniae in order to further determine its antifungal susceptibility pattern...
- Efficacy, safety, and plasma pharmacokinetics of escalating dosages of intravenously administered ravuconazole lysine phosphoester for treatment of experimental pulmonary aspergillosis in persistently neutropenic rabbitsRuta Petraitiene
Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Antimicrob Agents Chemother 48:1188-96. 2004..Intravenously administered ravuconazole lysine phosphoester showed dose-dependent efficacy and an excellent safety profile for the treatment of invasive pulmonary aspergillosis in persistently neutropenic rabbits...
- In vitro activity of anidulafungin against selected clinically important mold isolatesZekaver Odabasi
Laboratory of Mycology Research, Division of Infectious Diseases, University of Texas Houston Medical School, Houston, Texas 77030, USA
Antimicrob Agents Chemother 48:1912-5. 2004....
- In vitro interactions between amphotericin B, itraconazole, and flucytosine against 21 clinical Aspergillus isolates determined by two drug interaction modelsD T A Te Dorsthorst
Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ Nijmegen, The Netherlands
Antimicrob Agents Chemother 48:2007-13. 2004..However, the correlation of these results with clinical outcome remains difficult and needs to be further investigated...
- Effects of voriconazole on Cryptococcus neoformansDavid van Duin
Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
Antimicrob Agents Chemother 48:2014-20. 2004..The high activity of voriconazole against both melanized and nonmelanized cells results suggest that voriconazole may be a particularly valuable drug for cryptococcosis...
- Impact of lysozyme and lactoferrin on oral Candida isolates exposed to polyene antimycotics and fluconazoleS Anil
Oral Bio Sciences, Faculty of Dentistry, University of Hong Kong
Oral Dis 8:199-206. 2002....
- Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanesClarissa K L Ng
School of Chemistry, The University of Sydney, 2006 NSW, Australia
Bioorg Med Chem 15:3422-9. 2007..However, shortening or removing the alkyl chains attached to the amino groups had little effect on antifungal activity and significantly reduced haemolytic activity. Only octenidine was a strong inhibitor of fungal phospholipase B1...
- Fungal infections in neonates: update on prevention and treatmentD A Kaufman
Department of Pediatrics, University of Virginia School of Medicine Charlottesville, VA 22908, USA
Minerva Ginecol 59:311-29. 2007..Liposomal amphotericin formulations and echinochandins are currently being studied in neonates. Prevention for high risk patients is now feasible with fluconazole prophylaxis...
- [Investigation of the activity of the preparation cerbiden against Candida spp]N P Hladun
Taras Shevchenko Kyiv National University, 2 12 Acad Glushkov Avenue, Kyiv, 03022, Ukraine
Mikrobiol Z 64:57-61. 2002..High cerbiden activity against clinical and museum strains of Candida albicans, C. tropicalis, C. krusei, C. parapsilosis, C. guilliermondii, sensitive and resistant to nystatin, amphotericin B and clotrimazole was determined...
- Caspofungin versus amphotericin B for invasive candidiasisAdam L Brown
N Engl J Med 348:1287-8; author reply 1287-8. 2003
- Systemic mycoses in the immunocompromised host: an update in antifungal therapyD P Kontoyiannis
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M D Anderson Cancer Center, Houston 77030, USA
J Hosp Infect 53:243-58. 2003..Ongoing and future studies will determine their exact role in the management of different mycoses. The acceleration of antifungal drug discovery offers promise for the management of these difficult to treat opportunistic infections...
- Activity of micafungin (FK463) against an itraconazole-resistant strain of Aspergillus fumigatus and a strain of Aspergillus terreus demonstrating in vivo resistance to amphotericin BP A Warn
School of Medicine, University of Manchester, Manchester, UK
J Antimicrob Chemother 51:913-9. 2003..terreus infection. No treatment regime was able to totally clear the liver or kidneys in either model. The data indicate that FK463 may have a clinical role in the treatment of life-threatening invasive aspergillosis...
- Differential fungicidal activities of amphotericin B and voriconazole against Aspergillus species determined by microbroth methodologyJoseph Meletiadis
Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
Antimicrob Agents Chemother 51:3329-37. 2007....
- In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agentsNikolaos G Almyroudis
Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, USA
Antimicrob Agents Chemother 51:2587-90. 2007..The significant in vitro activity of posaconazole against several species appears to support its reported clinical efficacy. Decreased susceptibility to amphotericin B was noted with Cunninghamella bertholletiae...
- In vitro activity of terbinafine against medically important non-dermatophyte species of filamentous fungiGuillermo Garcia-Effron
Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo km 2, 28220 Majadahonda, Madrid, Spain
J Antimicrob Chemother 53:1086-9. 2004..The activity in vitro of terbinafine against 442 clinical isolates of several species of filamentous fungi was analysed...
- Effects of melanin upon susceptibility of Cryptococcus to antifungalsReiko Ikeda
Department of Microbiology, Meiji Pharmaceutical University, Kiyose, Tokyo 204 8588, Japan
Microbiol Immunol 47:271-7. 2003..Fluconazole, in contrast, was not removed from solution by melanin. This suggests that neoformans cryptococcal melanin deposited amphotericin B in the cell wall binds, reducing its effective concentrations...
- Treatment of a clinically relevant plant-pathogenic fungus with an agricultural azole causes cross-resistance to medical azoles and potentiates caspofungin efficacyAlbrecht Serfling
Faculty of Agriculture, Institute of Agricultural and Nutritional Sciences, Phytopathology and Plant Protection, Martin Luther University Halle Wittenberg, D 06099, Halle Saale, Germany
Antimicrob Agents Chemother 51:3672-6. 2007..Azole-adapted strains were less sensitive to all azoles tested but showed increased sensitivity to caspofungin, amphotericin B, and nystatin. Viability staining and infection assays with excised human skin confirmed these data...
- Antifungal susceptibility of clinical and environmental isolates of Cryptococcus neoformans to four antifungal drugs determined by two techniquesE M P Moraes
Department of Microbiology, Institute of Biological Sciences, Minas Gerais, Brazil
Mycoses 46:164-8. 2003..was applied, a fact possibly related to the greater difficulty for treatment of the disease caused by this fungal variety...
- Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulationW Lamar Smith
Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
Antimicrob Agents Chemother 46:3532-9. 2002..This most likely explains the inhibition of azole and terbinafine trailing by TSA and, more generally, provides evidence that trailing is mediated by upregulation of target enzymes and multidrug transporters...
- Activity of posaconazole in treatment of experimental disseminated zygomycosisEric Dannaoui
Department of Medical Microbiology, University Medical Center, St Radboud, 6500 HB Nijmegen, The Netherlands
Antimicrob Agents Chemother 47:3647-50. 2003..Posaconazole had no beneficial effects against R. oryzae but showed partial activity against A. corymbifera. Posaconazole had a clear dose-response effect against R. microsporus...
- Molecular mechanisms of itraconazole resistance in Candida dubliniensisEmmanuelle Pinjon
Microbiology Research Unit, Department of Oral Medicine and Oral Pathology, School of Dental Science, Trinity College, University of Dublin, Dublin 2, Republic of Ireland
Antimicrob Agents Chemother 47:2424-37. 2003..dubliniensis derivatives. However, the mechanism(s) of itraconazole resistance in the remaining seventh derivative has yet to be determined...
- New drugs, old drugs - dear drugs, cheap drugsBernard Hirschel
Swiss Med Wkly 132:301-2. 2002
- In vivo characterization of A-192411: a novel fungicidal lipopeptide (II)Jonathan A Meulbroek
Infectious Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064, USA
Bioorg Med Chem Lett 13:495-7. 2003..A-192411 also slightly prolonged the survival of immunocompromised mice infected systemically with Aspergillus fumigatus...
- Genome-wide expression profiling reveals genes associated with amphotericin B and fluconazole resistance in experimentally induced antifungal resistant isolates of Candida albicansKatherine S Barker
Department of Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, Memphis, USA
J Antimicrob Chemother 54:376-85. 2004..The aim of this study was to identify changes in the gene expression profile of Candida albicans associated with the acquisition of experimentally induced resistance to amphotericin B and fluconazole...
- Anidulafungin pharmacokinetics and microbial response in neutropenic mice with disseminated candidiasisTawanda Gumbo
Division of Infectious Diseases, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9113, USA
Antimicrob Agents Chemother 50:3695-700. 2006..This pharmacokinetic-pharmacodynamic picture of anidulafungin persistence in tissues and the resultant persistent fungal decline should be exploited to improve the efficacy of anidulafungin therapy for candidemia...
- Post-antifungal effect of polyene, azole and DNA-analogue agents against oral Candida albicans and Candida tropicalis isolates in HIV diseaseS Anil
Oral Bio-Sciences, Faculty of Dentistry, University of Hong Kong
J Oral Pathol Med 30:481-8. 2001..albicans species in the face of antifungal therapy for oropharyngeal candidiasis...
- Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilmsG Ramage
Department of Microbiology, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, Texas 78245, USA
Antimicrob Agents Chemother 45:2475-9. 2001....
- In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patientsWilliam J Steinbach
Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
Antimicrob Agents Chemother 48:4922-5. 2004..We were not able to detect a difference in calcineurin inhibitor antifungal activity against isolates from transplant recipients and nontransplant patients...
- Antifungal resistance: the clinical frontJohn R Perfect
Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA
Oncology (Williston Park) 18:15-22. 2004..Caspofungin and voriconazole show good activity against most Candida species and may be good alternatives for patients with Candida glabrata and Candida krusei infections and for those with relapsing infections...
- Prophylactic role of immunomodulators in treatment of systemic candidiasis in leukopenic miceM Alam Khan
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India
J Drug Target 12:425-33. 2004..Efficacy of the treatment was evaluated on the basis of survival of the animals as well as fungal load in systemic circulation and various organs viz. liver, kidney, spleen and lungs of the treated animals...
- Breakthrough candida Infection in a preterm infant with congenital cutaneous Candida albicans infectionAmos Adler
Department of Neonatology, Meir Medical Center, Kfar Saba 95847, Israel
Am J Perinatol 22:169-72. 2005..We discuss the pathogenesis of breakthrough infections, and the relevance of antifungal resistance and sensitivities testing...
- Antifungal treatment in pediatric patientsTheoklis E Zaoutis
Department of Pediatrics, Division of Infectious Diseases, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Drug Resist Updat 8:235-45. 2005....
- In vitro activities of voriconazole in combination with three other antifungal agents against Candida glabrataFrancesco Barchiesi
Istituo di Malattie Infettive e Medicina Pubblica, Universita Politecnica delle Marche, Azienda Ospedaliera Umberto I degrees, Via Conca, 60020 Torrette di Ancona, Ancona, Italy
Antimicrob Agents Chemother 48:3317-22. 2004..Further studies are warranted to elucidate the potential beneficial effects of such combination regimens in vivo...
- Effect of pH on the in vitro activities of amphotericin B, itraconazole, and flucytosine against Aspergillus isolatesD T A Te Dorsthorst
Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
Antimicrob Agents Chemother 48:3147-50. 2004..0 than at pH 7.0. The poor correlation between in vitro results and clinical outcome could be due to a difference in pH between the in vitro susceptibility test and at the site of infection...
- [Antifungal susceptibility of clinically isolated Candida albicans by broth microdilution method]T Yamazumi
Department of Clinical Pathology, Kinki University School of Medicine
Kansenshogaku Zasshi 72:813-9. 1998..There were two flucytosine resistant strains. The MICs of amphotericin B were tightly clustered and resistant strain were not observed...
- Caspofungin in combination with amphotericin B against Candida parapsilosisFrancesco Barchiesi
Istituto di Malattie Infettive e Medicina Pubblica, Universita Politecnica delle Marche, Azienda, Ospedaliero Universitaria, Ospedali Riuniti Umberto I Lancisi Salesi, Via Conca, 60020 Torrette, Ancona, Italy
Antimicrob Agents Chemother 51:941-5. 2007..Higher doses of the echinocandin (i.e., 5 and 10 mg/kg/day) combined with the polyene did not show any advantage over CAS alone. Overall, our study showed a positive interaction of CAS and AMB against C. parapsilosis...
- Efficacy of voriconazole in a guinea pig model of invasive trichosporonosisCarolina Serena
Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, Reus, Spain
Antimicrob Agents Chemother 50:2240-3. 2006..VRC was more effective than amphotericin B in prolonging survival and reducing tissue burden. The best results were obtained with VRC at 10 mg/kg of body weight/day...
- Increasing in vitro resistance to fluconazole in Cryptococcus neoformans Cambodian isolates: April 2000 to March 2002Borann Sar
Laboratory of Medical Microbiology, Unit of Clinical Testing, Institut Pasteur du Cambodge, 5 Boulevard Monivong, BP 983, Phnom Penh, Cambodia
J Antimicrob Chemother 54:563-5. 2004..Hospitalized patients were given amphotericin B for initial therapy followed by fluconazole for maintenance therapy. The antifungal drug susceptibility of Cryptococcus neoformans isolated from cerebrospinal fluid (CSF) was determined...
- Epidemiology and outcome of infections due to Aspergillus terreus: 10-year single centre experienceCornelia Lass-Flörl
Department of Hygiene, Microbiology and Social Medicine, Medical University of Innsbruck, Innsbruck, Austria
Br J Haematol 131:201-7. 2005..terreus causes systemic infections of endemic character in Tyrol, Austria. The onset of A. terreus infection depends not on the degree of immunosuppression but on environmental Aspergillus spp. exposure...
- In vitro susceptibility of clinical isolates of Zygomycota to amphotericin B, flucytosine, itraconazole and voriconazoleA Gomez-Lopez
Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo km 2, 28220 Majadahonda, Madrid, Spain
J Antimicrob Chemother 48:919-21. 2001..The species of Zygomycota tested were resistant in vitro to flucytosine, itraconazole and voriconazole. Amphotericin B showed the best activity against most of the strains evaluated...
- A comparative study of the post-antifungal effect (PAFE) of amphotericin B, triazoles and echinocandins on Aspergillus fumigatus and Candida albicansElias K Manavathu
Division of Infectious Diseases, Department of Internal Medicine, 427 Lande Building, Wayne State University, 550 E Canfield, Detroit, MI 48201, USA
J Antimicrob Chemother 53:386-9. 2004..To study the post-antifungal effect (PAFE) of antifungal drugs on Aspergillus fumigatus by a radiometric assay and compare the results with those obtained for Candida albicans...
- Quantitative PCR assay to measure Aspergillus fumigatus burden in a murine model of disseminated aspergillosis: demonstration of efficacy of caspofungin acetateJ C Bowman
Department of Human and Animal Infectious Disease Research, Merck Research Laboratories, Rahway, New Jersey 07065-0900, USA
Antimicrob Agents Chemother 45:3474-81. 2001..Because of its much larger dynamic range, the qPCR assay is superior to traditional CFU determination for monitoring the progression of disseminated aspergillosis and evaluating the activity of antifungal antibiotics against A. fumigatus.
- Suppression of maize root diseases caused by Macrophomina phaseolina, Fusarium moniliforme and Fusarium graminearum by plant growth promoting rhizobacteriaK K Pal
Division of Microbiology, Indian Agricultural Research Institute, New Delhi
Microbiol Res 156:209-23. 2001..Pseudomonas sp. EM85 produced antifungal antibiotics (Afa+), siderophore (Sid+), HCN (HCN+) and fluorescent pigments (Flu+) besides exhibiting plant growth ..
- Biosynthetic engineering of polyene macrolides towards generation of improved antifungal and antiparasitic agentsPatrick Caffrey
School of Biomolecular and Biomedical Science and Centre for Synthesis and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
Curr Top Med Chem 8:639-53. 2008..They are medically important as antifungal antibiotics but their therapeutic use is limited by serious side effects...
- Biocontrol of avocado dematophora root rot by antagonistic Pseudomonas fluorescens PCL1606 correlates with the production of 2-hexyl 5-propyl resorcinolFrancisco M Cazorla
Departamento de Microbiologia, Facultad de Ciencias, Universidad de Malaga, Campus Universitario de Teatinos, S N, 29071 Malaga, Spain
Mol Plant Microbe Interact 19:418-28. 2006..fluorescens PCL1606 did not correspond to any of the major classes of antifungal antibiotics produced by Pseudomonas biocontrol strains...
- Antifungal characteristics of a fluorescent Pseudomonas strain involved in the biological control of Rhizoctonia solaniK K Pal
Division of Microbiology, Indian Agricultural Research Institute, New Delhi
Microbiol Res 155:233-42. 2000..The isolate produced HCN (HCN+), siderophore (Sid+), fluorescent pigments (Flu+) and antifungal antibiotics (Afa+)...
- Regulation of antibiotic production in root-colonizing Peudomonas spp. and relevance for biological control of plant diseaseDieter Haas
Institut de Microbiologie Fondamentale, Universite de Lausanne, CH 1015 Lausanne, Switzerland Email
Annu Rev Phytopathol 41:117-53. 2003..colonization, induction of systemic resistance in the plant, and the production of diffusible or volatile antifungal antibiotics. Evidence that these compounds are produced in situ is based on their chemical extraction from the ..
- Characterization of antimicrobial peptides against a US strain of the rice pathogen Rhizoctonia solaniS Oard
LSU AgCenter Biotechnology Laboratory, Louisiana State University, Baton Rouge, LA 70803, USA
J Appl Microbiol 97:169-80. 2004..To identify antimicrobial peptides with high lytic activity against Rhizoctonia solani strain LR172, causal agent of rice sheath blight and aerial blight of soyabeans in the US...
- [Diversity of neutrotolerant acidophilic Streptomycetes isolated from acidic soils in Yunnan Province]Chunguang Xu
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Wei Sheng Wu Xue Bao 48:421-5. 2008..acitnomycetes are active in the turnover of organic matter in acid litters and soils, and are a source of antifungal antibiotics and acid-stable enzymes...
- Characteristics and biotechnological applications of microbial cholesterol oxidasesNoriyuki Doukyu
Bio Nano Electronic Research Center, Toyo University, Kujirai, Kawagoe, Saitama, Japan
Appl Microbiol Biotechnol 83:825-37. 2009..implicated in the cholesterol metabolism, the bacterial pathogenesis, and the biosynthesis of macrolide antifungal antibiotics. Cholesterol oxidase has been reported from a variety of microorganisms, mostly from actinomycetes...
- Sensitivity of ornithophillic fungi to some drugsAvni Patel
Department of Applied Microbiology and Biotechnology, Dr Hari Singh Gour Vishwavidhyalaya, Sagar 470 003, M P, India
Hindustan Antibiot Bull 44:49-52. 2002..of Microsporum were tested by 'Spore germination' and 'Disc diffusion method' against the two well known antifungal antibiotics i.e. griseofulvin and mycostatin (polyene antibiotic)...
- Identification of antifungal antibiotics of Bacillus species isolated from different microhabitats using polymerase chain reaction and MALDI-TOF mass spectrometrySarangi N P Athukorala
Department of Plant Science, University of Manitoba, Winnipeg, Canada
Can J Microbiol 55:1021-32. 2009..To the best of our knowledge, this is the first report of a B. mycoides strain that carries biosynthetic genes and produces fengycin and surfactin...
- Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathwayT Brautaset
UNIGEN Center for Molecular Biology, Department of Biotechnology, Norwegian University of Science and Technology, Trondheim, N 7489, Norway
Chem Biol 7:395-403. 2000..Molecular cloning and characterization of the genes governing the nystatin biosynthesis is of considerable interest because this information can be used for the generation of new antifungal antibiotics.
- Genetic analysis of nystatin and amphotericin biosynthesisSergey Zotchev
Department of Biotechnology, Norwegian University of Science and Technology, Trondheim, Norway
Methods Enzymol 459:243-58. 2009The polyene macrolides nystatin A1 and amphotericin B are effective but toxic antifungal antibiotics that are also active against enveloped viruses, protozoan parasites and pathogenic prion proteins...
- Current approaches to diagnosis and treatment of fungal infections in children infected with human immuno deficiency virusF M Muller
Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
Eur J Pediatr 158:187-99. 1999..broad-spectrum third generation triazoles and novel fungicidal lipopeptides of the echinocandin class of antifungal antibiotics have entered clinical trials...
- Selective isolation of members of the Streptomyces violaceoruber clade from soilKannika Duangmal
School of Biology, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK
FEMS Microbiol Lett 245:321-7. 2005..isolation medium, dextran-histidine-sodium chloride-mineral salts agar supplemented with antibacterial and antifungal antibiotics, also supported the growth of representatives of the S. violaceoruber clade...
- Antifungal antibiotics from Calcarisporium thermophilum: a new source of 15-azahomosterol derivativesP Chrisp
Department of Pharmaceutical Sciences, University of Nottingham
Z Naturforsch C 45:179-86. 1990..Calcarisporium thermophilum is the second microorganism known to synthesize these unusual 15-azahomosterol derivatives...
- Selection for biocontrol bacteria antagonistic toward Rosellinia necatrix by enrichment of competitive avocado root tip colonizersClara Pliego
IFAPA, Centro de Churriana CICE Junta de Andalucía, Cortijo de la Cruz s n, 29140 Churriana, Malaga, Spain
Res Microbiol 158:463-70. 2007..Only one of these strains, Pseudomonas sp. AVO94, produced a compound that could be related to antifungal antibiotics. All of the ten selected strains showed twitching motility, a cell movement involved in competitive ..
- Forest soil metagenome gene cluster involved in antifungal activity expression in Escherichia coliEu Jin Chung
Division of Applied Biology, College of Natural Resources and Life Science, Dong A University, Busan 604 714, Republic of Korea
Appl Environ Microbiol 74:723-30. 2008..Our results suggested the metagenomic approach as an alternative to search for novel antifungal antibiotics from unculturable soil bacteria...
- [New antifungal antibiotics, bacillopeptins and fusaricidins]Miyuki Kaneda
Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
Yakugaku Zasshi 122:651-71. 2002We isolated four strains of bacteria producing antifungal antibiotics from the rhizosphere of garlic with basal rot caused by the plant pathogenic fungal strain Fusarium oxysporum...
- [The immune response to fungal infections]Piotr Kurnatowski
Zakład Biologii i Parazytologii Lekarskiej, Uniwersytet Medyczny, Plac Hallera 1, 90 647 Łódź
Wiad Parazytol 56:23-7. 2010..the nature and function of the immune system in mycoses is necessary to enable improvements in pharmacotherapy with antifungal antibiotics and chemotherapeutics, as well as to treatments based on immunotherapy and vaccination.
- Cloning, sequencing, and characterization of the pradimicin biosynthetic gene cluster of Actinomadura hibisca P157-2Byung Chul Kim
Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136 713, Korea
J Microbiol Biotechnol 17:830-9. 2007Pradimicins are potent antifungal antibiotics having an unusual dihydrobenzo[alpha]naphthacenequinone aglycone substituted with D-alanine and sugars. Pradimicins are polyketide antibiotics produced by Actinomadura hibisca P157-2...
- Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cellsManabu Kawada
Numazu Bio Medical Research Institute, Microbial Chemistry Research Center, 18 24 Miyamoto, Numazu shi, Shizuoka 410 0301, Japan
Int J Cancer 126:810-8. 2010..As a result, we have found that leucinostatins and atpenins, natural antifungal antibiotics, inhibit the growth of DU-145 cells cocultured with PrSC more strongly than that of DU-145 cells alone...
- Effect of liquid culture requirements on antifungal antibiotic production by Streptomyces rimosus MY02Jicheng Yu
Department of Bioengineering, Dalian Nationalities University, Dalian, PR China
Bioresour Technol 99:2087-91. 2008..e. initial pH and temperature) on production of antifungal antibiotics by S. rimosus MY02 was investigated in our work...
- New antifungal antibiotics pradimicins FA-1 and FA-2: D-serine analogs of pradimicins A and CY Sawada
Bristol Myers Research Institute, Ltd, Tokyo Research Center, Japan
J Antibiot (Tokyo) 43:1223-9. 1990..Pradimicin FA-1 has an N-methylamino sugar and D-xylose. Pradimicin FA-2 is the des-N-methyl analog of pradimicin FA-1. The in vitro and in vivo antifungal activity of the analogs was comparable to that of pradimicin A...
- Isolation and characterization of two new antifungal antibiotics from a basidiomyceteMin Chu
Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey, USA
J Antibiot (Tokyo) 56:9-15. 2003..Both components were identified as glycolipids and displayed antifungal activity against Saccharomyces and Aspergillus strains...
- Generation of new benanomicin analogues by biotransformation using Escherichia coli expressing actinomycete cytochrome P450Hiroyuki Kumagai
Microbial Chemistry Research Center, Tokyo, Japan
J Antibiot (Tokyo) 61:394-9. 2008Benanomicins were found as antifungal antibiotics from the culture of an actinomycete with potent antifungal activities in vitro and in vivo...
- Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3betaJoel T Adler
Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, H4 750 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
Mol Cancer Ther 8:914-20. 2009..Thus, there is an urgent need for new treatment modalities. Tautomycin and tautomycetin are antifungal antibiotics isolated from Streptomyces spiroverticillatus and Streptomyces griseochromogens, respectively...
- Dorrigocins: novel antifungal antibiotics that change the morphology of ras-transformed NIH/3T3 cells to that of normal cells. III. Biological properties and mechanism of actionS Kadam
Abbott Laboratories, Abbott Park, Illinois 60064
J Antibiot (Tokyo) 47:875-80. 1994..The activity of these compounds was not dependent on inhibition of prenylation or protein synthesis. Dorrigocin A was instead found to inhibit the carboxyl methylation in K-ras transformed cells...
- Probiotic bacteria for prophylaxis and therapy of candidiasisE Balish
University of Wisconsin Medical School, Departments of Surgery and Medical Microbiology and Immunology, Madison, WI 53706 1532, USA
Rev Iberoam Micol 15:261-4. 1998..The increased incidence of Candida infections, their increasing resistance to antifungal antibiotics and the fact that vaccines to protect against candidiasis are not yet available (and may not work in ..
- Biological control of soil-borne pathogens by fluorescent pseudomonadsDieter Haas
Department of Fundamental Microbiology, University of Lausanne, CH 1015 Lausanne, Switzerland
Nat Rev Microbiol 3:307-19. 2005..During root colonization, these bacteria produce antifungal antibiotics, elicit induced systemic resistance in the host plant or interfere specifically with fungal pathogenicity ..
- Management of invasive mycoses in hematology patients: current approachesJohn R Perfect
Division of Infectious Disease, Duke University Medical Center, Durham, North Carolina 27710, USA
Oncology (Williston Park) 18:5-14. 2004..If patients are intolerant of or refractory to conventional therapy, effective alternatives include a lipid formulation of amphotericin B or an echinocandin...
- 5-methylcoumaranones from Mutisia friesiana and their bioactivityCarmen I Viturro
Facultad de Ingenieria, Universidad Nacional de Jujuy, Gorriti 237, 4600 S S de Jujuy, Jujuy, Argentina
J Nat Prod 67:778-82. 2004..The presence of 5-methylcoumaranones A-D is biosynthetically related to 5-methylcoumarins and phenolic derivatives previously isolated from M. friesiana...
- Short synthesis of the 6,6-spiroketal cores of spirofungins A and BLuiz C Dias
Instituto de Quimica, Universidade Estadual de Campinas, UNICAMP, C P 6154 13084 971, Campinas, SP, Brazil
Org Lett 6:2587-90. 2004reaction: see text] Initial efforts toward the total synthesis of the antifungal antibiotics spirofungins A and B are reported. A short and efficient synthesis of the C9-C20 6,6-spiroketal fragments of both compounds is described...
- The effect of fatty acid substitution on the in vitro release of amphotericin B from micelles composed of poly(ethylene oxide)-block-poly(N-hexyl stearate-L-aspartamide)Afsaneh Lavasanifar
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Alberta T6G 2N8, Edmonton, Canada
J Control Release 79:165-72. 2002..The results point to a nanoscopic drug depot that may release AmB at controlled rates...
- [Celso's kerion induced erythema nodosum]D Mata Zubillaga
An Pediatr (Barc) 69:98-9. 2008
- Protection by tetracyclines against ion transport disruption caused by nystatin in human airway epithelial cellsY Ito
Second Division Respiratory Division, First Department of Physiology, School of Medicine, Nagoya University, Tsurumai cho, Nagoya, 466 8550, Japan
Toxicol Appl Pharmacol 177:232-7. 2001Polyene antifungal antibiotics like nystatin form monovalent cation pores on the plasma membrane that perturb the intracellular electrolyte milieu, resulting in cell damage...
- Treatment of aspergillosisMeinolf Karthaus
Clin Infect Dis 47:427; author reply 427-8. 2008
- Detection of griseofulvin in a marine strain of Penicillium waksmanii by ion trap mass spectrometryK E Petit
SMAB Substances Marines à Activité Biologique, Universite de Nantes, ISOMer, Faculte de Pharmacie, BP 53 508, 44035 Nantes Cedex 01, France
J Microbiol Methods 58:59-65. 2004..It is the first description of griseofulvin production by a strain of P. waksmanii and the first chemical study of a strain of this species isolated from marine temperate cold water...
- [Rhinocerebral mucormycosis: apropos of 4 new Tunisian cases]F Makni
Laboratoire de Parasitologie-Mycologie, CHU H. Bourguiba, Sfax, Tunisie
Bull Soc Pathol Exot 94:239-42. 2001..Two patients had a fatal outcome. This infection has a severe prognosis and necessitates early diagnosis...
- Effects of caspofungin (MK-0991) and anidulafungin (LY303366) on phagocytosis, oxidative burst and killing of Candida albicans by human phagocytesU Frank
Institute of Environmental Medicine and Hospital Epidemiology, Freiburg University Hospital, Hugstetterstrasse 55, 79106, Freiburg, Germany
Eur J Clin Microbiol Infect Dis 23:729-31. 2004..4% and 43.2%, respectively, compared to 37.9% in controls; P<0.05). In conclusion, caspofungin significantly improves oxidative burst and intracellular killing, which may be advantageous for clinical therapy...
- Water-soluble amphotericin B-polyvinylpyrrolidone complexes with maintained antifungal activity against Candida spp. and Aspergillus spp. and reduced haemolytic and cytotoxic effectsEkatherina Charvalos
School of Health and Caring Professions, Technological Educational Institution of Athens, Pallikaridou 1, GR 122 10 Aegaleo, Greece
J Antimicrob Chemother 57:236-44. 2006..Water-soluble complexes of AmB and polyvinylpyrrolidone (AmB-PVP) could display lower cytotoxicity while maintaining antifungal activity...
- In vitro susceptibilities of Madurella mycetomatis to itraconazole and amphotericin B assessed by a modified NCCLS method and a viability-based 2,3-Bis(2-methoxy-4-nitro-5- sulfophenyl)-5-[(phenylamino)carbonyl]-2H-tetrazolium hydroxide (XTT) assayAbdalla O A Ahmed
Mycetoma Research Group, Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
Antimicrob Agents Chemother 48:2742-6. 2004..The XTT assay was reproducible and sensitive for both antifungals. Itraconazole (MIC at which 50% of the isolates tested are inhibited [MIC(50)]) of 0.06 to 0.13 mg/liter) was superior to amphotericin B (MIC(50) of 0.5 to 1.0 mg/liter)...
- Candida glabrata infection after total hip arthroplastyN Ramamohan
University Department of Orthopaedic Surgery, Western Infirmary, Glasgow, G11 6NT, UK
J Infect 42:74-6. 2001..We report successful treatment of a total hip replacement infected with this rare organism by a two-stage revision and synergistic combination antifungal therapy with Amphotericin B and 5-Flucytosine...
- Posaconazole: a new oral antifungal agent with an expanded spectrum of activityMichele I Morris
Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Am J Health Syst Pharm 66:225-36. 2009..The pharmacology, pharmacokinetics, pharmacodynamics, spectrum of activity and resistance, clinical utility, adverse effects, dosage and administration, and recommended monitoring of posaconazole are reviewed...
- Novel Antifungal Strategies for Lethal MucormycosisAshraf Ibrahim; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Discovering New Anti-Infective Agents from LysobacterLiangcheng Du; Fiscal Year: 2013..To develop HSAF as a new type of antifungal antibiotics, it is important to understand the biosynthetic mechanism for the novel chemical structure...
- GENOMIC SEQUENCING OF CANDIDA ALBICANSRonald Davis; Fiscal Year: 1999..The limited number of effective and safe antifungal antibiotics underscores the importance of increasing our understanding of the unique genetic traits of C. albicans...
- ANTISENSE INHIBITION OF FUNGAL GROWTHCarol Enderlin; Fiscal Year: 1993..Treatment of fungal infections is difficult due to a lack of effective antifungal antibiotics. Even after 29 years of use, Amphotericin is still the drug of choice to treat systemic fungal infections; ..
- Synthesis of Papulacandins A-D; New Antifungal AnalogsGEORGE O DOHERTY; Fiscal Year: 2005..synthetic/biological investigation of the papulacandins, a class of potent mono-, di-, and trisaccharide antifungal antibiotics. Our study revolves around a unique de novo asymmetric synthetic approach to the papulacandin ring system, ..
- Treatment of Fungal Infections with ATAK CellsAshraf Ibrahim; Fiscal Year: 2004..Furthermore, the genetic construct targeting ATAK cells to Candida can easily be adapted to any other pathogen against which a MAb has been raised. ..
- Antifungal Drug Susceptibility of Cryptococcus neoformansRobert Larsen; Fiscal Year: 2009....
- Transplant Associated Infection Surveillance NetworkPeter Pappas; Fiscal Year: 2008..Finally, the establishment of a bank will be invaluable in the development and validation of newer diagnostic assays. ..
- Calcineurin and Aspergillus fumigatus PathogenesisWILLIAM STEINBACH; Fiscal Year: 2008..I will also test the non-immunosuppressive calcineurin inhibitor analogs to decrease the total level of immunosuppression and therefore increase the overall antifungal efficacy of exploiting the calcineurin pathway. ..
- Imaging of Pulmonary Cancer: Overcoming LimitationsJane Ko; Fiscal Year: 2007..The proposed method will enable early recognition of nodule growth and, therefore, the early diagnosis of malignancy. ..
- Epothilone Analogs by Partial Chemical SynthesisDavid Myles; Fiscal Year: 2002..The proposed epothilone analogs with increased solubility will have a potentially competitive advantage for a $2 billion per year market for the treatment of breast, lung and ovarian cancers. ..
- ASYMMETRIC SYNTHESIS OF VANCOMYCIN ANTIBIOTICSDavid Evans; Fiscal Year: 2001..During the course of this project we intend to confirm (correct) the absolute stereochemical assignments of the principal members of this family by total synthesis. ..
- MELANOGENESIS IN CRYPTOCOCCUS NEOFORMANSJOSHUA NOSANCHUK; Fiscal Year: 2002..To explore the structure of melanin using biochemistry, phage display peptide libraries and mAbs; and 4. To use peptides and mAbs to study C. neoformans melanogenesis in vivo and in vitro. ..
- ASYMMETRIC SYNTHESIS OF IONOPHORE/MACROLIDE ANTIBIOTICSDavid Evans; Fiscal Year: 2005..Our goal has been to set in place all of the reactions necessary for the rapid assemblage of any polyketide target structure. ..
- Clinical Suspicion of TB: A Technology Assessment ToolAntonino Catanzaro; Fiscal Year: 2007..It will help define the role of serologic testing in the diagnosis of PTB. ..
- EVALUATION OF NIKKOMYCIN Z PHARMACOLOGY FOR TREATMENT OF UNCOMPLICATED COCCIDIODEDavid Nix; Fiscal Year: 2009..By carrying out the proposed work, the investigators will resume the clinical development of nikkomycin Z as a potentially curative therapy for coccidioidomycosis so that it may become a candidate for final commercial development. ..
- Antibody Protection in HistoplamosisJOSHUA NOSANCHUK; Fiscal Year: 2009..These studies are expected to lead to insights into H. capsulatum pathogenesis and initiate the development of new therapeutic and diagnostic reagents. ..
- Genetic Determinants of A. Fumigatus SusceptibilityAimee Zaas; Fiscal Year: 2008..fumigatus infection, this proposal will identify and characterize genetic polymorphisms related to IA susceptibility in mice and validate these findings in a cohort of human bone marrow transplant donors and recipients. ..
- C. Neoformans Infection in Organ Transplant RecipientsNina Singh; Fiscal Year: 2005..Finally, the data regarding reactivation or primary infection has implications relevant for the prevention of C. neoformans infection in transplant recipients. ..
- Efficient synthesis of discodermolideGary Ashley; Fiscal Year: 2005..abstract_text> ..
- Mobilization of Candida albicans BiofilmsPeter Suci; Fiscal Year: 2007..albicans biofilm communities, it will provide the basis for development of methods for screening for adjuvant agents that will inhibit dissemination of these fungal infections. [unreadable] [unreadable] [unreadable]..
- Synthesis of Polyketides and TerpenesDavid A Evans; Fiscal Year: 2010..As a consequence, organic synthesis is a critical discipline that continues to have an important impact on the fields of both medicine and biology. ..
- Motilin Receptor Agonists for Diabetic GastroperesisDavid Myles; Fiscal Year: 2005....
- Fungal transporters: from resistance to new antifungalsRichard Cannon; Fiscal Year: 2008..This project will increase our understanding of efflux pump structure and function and identify pump inhibitors that could lead to new therapies for patients with opportunistic fungal infections. ..
- Prevention/diagnosis/fungal infections/transplantationBarbara Alexander; Fiscal Year: 2005..This approach will shorten the time from development to clinical implementation in therapeutic trials and guidelines. ..
- Interaction of H. capsulatum with Dendritic CellsSimon Newman; Fiscal Year: 2006..The results of these studies should provide significant insight into the pathogenesis of histoplasmosis and aid in the design of novel vaccine strategies for the prevention of disease. ..