anti inflammatory agents

Summary

Summary: Substances that reduce or suppress INFLAMMATION.

Top Publications

  1. ncbi Distribution and biological activities of the flavonoid luteolin
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Spain C Profesor Garcia Gonzalez, 41011, Sevilla, Spain
    Mini Rev Med Chem 9:31-59. 2009
  2. ncbi The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy study
    Keith L Hattotuwa
    Lung Pathology Unit, Imperial College School of Medicine at the Royal Brompton Hospital, London, United Kingdom
    Am J Respir Crit Care Med 165:1592-6. 2002
  3. ncbi Anti-inflammatory lipid mediators and insights into the resolution of inflammation
    Toby Lawrence
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0636, USA
    Nat Rev Immunol 2:787-95. 2002
  4. ncbi Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial
    Peter Calverley
    Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Lancet 361:449-56. 2003
  5. ncbi Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund's adjuvant-induced chronic arthritis model in the rat
    Zsuzsanna Helyes
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7643 Pecs, Szigeti u 12, Hungary
    Arthritis Rheum 50:1677-85. 2004
  6. pmc Anti-inflammatory effects of moxifloxacin on activated human monocytic cells: inhibition of NF-kappaB and mitogen-activated protein kinase activation and of synthesis of proinflammatory cytokines
    Taly Weiss
    Department of Cell Biology and Histology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Antimicrob Agents Chemother 48:1974-82. 2004
  7. ncbi Inhibition of the expression and activity of cyclooxygenase-2 by chicory extract
    C Cavin
    Quality and Safety Department, Nestle Research Center, P O Box 44, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    Biochem Biophys Res Commun 327:742-9. 2005
  8. ncbi Inflammatory processes in Alzheimer's disease
    Michael T Heneka
    Department of Neurology, Molecular Neurology Unit, University of Munster, Mendelstrasse 7, D 48149, Munster, Germany
    J Neuroimmunol 184:69-91. 2007
  9. ncbi Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease
    Neil C Barnes
    Department of Respiratory Medicine, London Chest Hospital, London, UK
    Am J Respir Crit Care Med 173:736-43. 2006
  10. ncbi The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules
    Andrew Johnston
    Department of Immunology, Landspitali University Hospital, 101 Reykjavik, Iceland
    Clin Immunol 114:154-63. 2005

Research Grants

  1. Reactive (AA)Amyloidosis
    Merrill D Benson; Fiscal Year: 2013
  2. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
  3. Targeting Inflammation for the Amelioration of Cisplatin-Hearing Loss
    Vickram Ramkumar; Fiscal Year: 2011
  4. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011
  5. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
  6. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2013
  7. PROSPECTIVE STUDIES OF DIET AND CANCER IN MEN AND WOMEN
    Walter C Willett; Fiscal Year: 2010
  8. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2010
  9. Discovery of Novel Anti-Inflammatory Phytochemicals on Human Cell Platforms
    ERIK MILLS SCHWIEBERT; Fiscal Year: 2010
  10. REGULATION OF NF-KAPPA B
    INDER MOHAN VERMA; Fiscal Year: 2013

Detail Information

Publications269 found, 100 shown here

  1. ncbi Distribution and biological activities of the flavonoid luteolin
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Spain C Profesor Garcia Gonzalez, 41011, Sevilla, Spain
    Mini Rev Med Chem 9:31-59. 2009
    ....
  2. ncbi The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy study
    Keith L Hattotuwa
    Lung Pathology Unit, Imperial College School of Medicine at the Royal Brompton Hospital, London, United Kingdom
    Am J Respir Crit Care Med 165:1592-6. 2002
    ..The data indicate that inhaled fluticasone does affect selected aspects of airway inflammation in COPD, and this may explain, in part, the decrease in exacerbations seen in long-term studies with fluticasone propionate...
  3. ncbi Anti-inflammatory lipid mediators and insights into the resolution of inflammation
    Toby Lawrence
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0636, USA
    Nat Rev Immunol 2:787-95. 2002
    ..This review focuses on this emerging area of inflammation research and describes the mediators and mechanisms that are currently stealing the headlines...
  4. ncbi Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial
    Peter Calverley
    Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Lancet 361:449-56. 2003
    ..We postulated that a combination of these treatments would be better than each component used alone...
  5. ncbi Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund's adjuvant-induced chronic arthritis model in the rat
    Zsuzsanna Helyes
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7643 Pecs, Szigeti u 12, Hungary
    Arthritis Rheum 50:1677-85. 2004
    ..This study was undertaken to examine this systemic "sensocrine" function of neuronally derived somatostatin in chronic inflammation in the Freund's complete adjuvant (CFA)-induced arthritis model...
  6. pmc Anti-inflammatory effects of moxifloxacin on activated human monocytic cells: inhibition of NF-kappaB and mitogen-activated protein kinase activation and of synthesis of proinflammatory cytokines
    Taly Weiss
    Department of Cell Biology and Histology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Antimicrob Agents Chemother 48:1974-82. 2004
    ..Its anti-inflammatory properties should be further assessed in clinical settings...
  7. ncbi Inhibition of the expression and activity of cyclooxygenase-2 by chicory extract
    C Cavin
    Quality and Safety Department, Nestle Research Center, P O Box 44, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    Biochem Biophys Res Commun 327:742-9. 2005
    ..Altogether, the data presented strongly support chicory root as a promising source of functional food ingredient, combining prebiotic and anti-inflammatory properties...
  8. ncbi Inflammatory processes in Alzheimer's disease
    Michael T Heneka
    Department of Neurology, Molecular Neurology Unit, University of Munster, Mendelstrasse 7, D 48149, Munster, Germany
    J Neuroimmunol 184:69-91. 2007
    ....
  9. ncbi Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease
    Neil C Barnes
    Department of Respiratory Medicine, London Chest Hospital, London, UK
    Am J Respir Crit Care Med 173:736-43. 2006
    ..No currently available treatment is reported to reduce the exaggerated airway wall inflammation of chronic obstructive pulmonary disease...
  10. ncbi The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules
    Andrew Johnston
    Department of Immunology, Landspitali University Hospital, 101 Reykjavik, Iceland
    Clin Immunol 114:154-63. 2005
    ..Thus, the suppression of T cell activation and T cell adhesion molecule expression, rather than apoptosis, mediated in part by adenosine or polyglutamated MTX or both, are important mechanisms in the anti-inflammatory action of MTX...
  11. ncbi Inflammation of atrium after cardiac surgery is associated with inhomogeneity of atrial conduction and atrial fibrillation
    Yosuke Ishii
    Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO, USA
    Circulation 111:2881-8. 2005
    ..Atrial fibrillation (AF) is common after cardiac surgery. Abnormal conduction is an important substrate for AF. We hypothesized that atrial inflammation alters atrial conduction properties...
  12. ncbi Apoptosis of airway epithelial cells induced by corticosteroids
    D R Dorscheid
    McDonald Research Laboratories, the iCAPTURE Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 164:1939-47. 2001
    ..This raises the possibility that at least one of the major components of chronic airway damage in asthma, epithelial shedding and denudation, may in part result from a major therapy for the disease...
  13. ncbi Cardiovascular management of septic shock
    R Phillip Dellinger
    Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Section of Critical Care Medicine, Cooper Health System, Camden 08103, USA
    Crit Care Med 31:946-55. 2003
  14. ncbi Rhinovirus-induced airway inflammation in asthma: effect of treatment with inhaled corticosteroids before and during experimental infection
    K Grunberg
    Department of Pulmonology, Department of Medical Decision Making, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Am J Respir Crit Care Med 164:1816-22. 2001
    ..The latter finding is in keeping with the limited protection of inhaled corticosteroids against acute asthma exacerbations...
  15. ncbi Risk and the efficacy of antiinflammatory agents: retrospective and confirmatory studies of sepsis
    Peter Q Eichacker
    Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Respir Crit Care Med 166:1197-205. 2002
    ..Accounting for this relationship may be necessary for the safe and effective development of antiinflammatory therapies for sepsis...
  16. ncbi TNF-alpha as a therapeutic target in inflammatory diseases, ischemia-reperfusion injury and trauma
    E Esposito
    IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    Curr Med Chem 16:3152-67. 2009
    ....
  17. ncbi Budesonide and the risk of pneumonia: a meta-analysis of individual patient data
    Don D Sin
    Providence Heart and Lung Institute, St Paul s Hospital iCAPTURE Centre, and Department of Medicine Division of Respirology, University of British Columbia, Vancouver, BC, Canada
    Lancet 374:712-9. 2009
    ..We aimed to establish the effects of inhaled budesonide on the risk of pneumonia in such patients...
  18. pmc Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics
    Richard S Jope
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Sparks Center 1057, 1720 Seventh Avenue South, Birmingham, AL 35294 0017, USA
    Neurochem Res 32:577-95. 2007
    ..Thus, GSK3 may contribute not only to primary pathologies in these diseases, but also to the associated inflammation, suggesting that GSK3 inhibitors may have multiple effects influencing these conditions...
  19. ncbi Needling therapies in the management of myofascial trigger point pain: a systematic review
    T M Cummings
    British Medical Acupuncture Society, London, England
    Arch Phys Med Rehabil 82:986-92. 2001
    ..To establish whether there is evidence for or against the efficacy of needling as a treatment approach for myofascial trigger point pain...
  20. ncbi Tumor necrosis factor antagonists: preliminary evidence for an emerging approach in the treatment of ocular inflammation
    Panagiotis G Theodossiadis
    Second Department of Ophthalmology, Laikon Hospital, Athens University Medical School, Greece
    Retina 27:399-413. 2007
    ..Until such results are available, knowledge regarding the use of anti-TNF regimens in ophthalmology is incomplete. However, the preliminary evidence points to a growing optimism for targeting TNF in patients with ocular inflammation...
  21. pmc Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane)
    Santosh K Sandur
    Cytokine Research Laboratory, Department of Experimental Therapeutics, Box 143, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Free Radic Biol Med 43:568-80. 2007
    ..Further, N-acetylcysteine partially reversed the effect of curcumin. Based on these results we conclude that curcumin mediates its apoptotic and anti-inflammatory activities through modulation of the redox status of the cell...
  22. ncbi Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile
    Carolin Daniel
    FEBG, First Department of Internal Medicine, Division of Gastroenterology and Clinical Nutrition, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Pharmacol Exp Ther 324:23-33. 2008
    ..Furthermore they suggest that early markers of inflammatory dendritic cell and Th17 differentiation qualify as new target molecules for both calcitriol and highly selective immune-modulating vitamin D analogs...
  23. ncbi Low-dose prednisone therapy for patients with early active rheumatoid arthritis: clinical efficacy, disease-modifying properties, and side effects: a randomized, double-blind, placebo-controlled clinical trial
    Amalia A van Everdingen
    Department of Rheumatology, Deventer Hospital, Box 5001, 7400 GC Deventer, The Netherlands
    Ann Intern Med 136:1-12. 2002
    ..Oral glucocorticoids combined with disease-modifying antirheumatic drugs are beneficial and retard radiologic joint damage in rheumatoid arthritis...
  24. ncbi Macrophage release of transforming growth factor beta1 during resolution of monosodium urate monohydrate crystal-induced inflammation
    Darshna R Yagnik
    Imperial College London, Hammersmith Hospital, London, UK
    Arthritis Rheum 50:2273-80. 2004
    ..The purpose of this study was to investigate whether MSU crystals induce macrophages to secrete antiinflammatory factor instead...
  25. pmc Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt
    Barbara Wegiel
    Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 284:21369-78. 2009
    ..Collectively, our findings elucidate a potentially important new molecular mechanism by which BV, through the enzymatic activity and phosphorylation of surface BVR (BVR)(surf) modulates the inflammatory response...
  26. ncbi The efficacy and safety of fluticasone propionate (250 microg)/salmeterol (50 microg) combined in the Diskus inhaler for the treatment of COPD
    Nicola A Hanania
    Baylor College of Medicine, Pulmonary Critical Care, Ben Taub General Hospital, 1504 Taub Loop, Houston, TX 77030, USA
    Chest 124:834-43. 2003
    ....
  27. ncbi Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase
    Peter J Barnes
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Lancet 363:731-3. 2004
    ..This hypothesis raises the possibility that novel therapeutic approaches might unlock this corticosteroid resistance, leading to more effective anti-inflammatory treatments for COPD and other severe inflammatory diseases...
  28. ncbi Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis
    Yuan H Yang
    Centre for Inflammatory Diseases, Monash University, Clayton, Victoria, Australia
    Arthritis Rheum 50:976-84. 2004
    ..This study investigated the role of Anx-1 in experimental arthritis and in GC-mediated inhibition of inflammation, using antigen-induced arthritis (AIA) in Anx-1 knockout (Anx-1(-/-)) mice...
  29. pmc Adalimumab for maintenance treatment of Crohn's disease: results of the CLASSIC II trial
    W J Sandborn
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Gut 56:1232-9. 2007
    ..Adalimumab induced clinical remission after four weeks in patients with active Crohn's disease in the CLASSIC I trial...
  30. ncbi The resolution of inflammation: anti-inflammatory roles for NF-kappaB
    Toby Lawrence
    Inflammation Biology Group, Centre d Immunologie Marseille Luminy, CNRS Inserm Université de la Méditerranée, Parc Scientifique de Luminy, 13288 Marseille, France
    Int J Biochem Cell Biol 42:519-23. 2010
    ..In this review we will discuss the emerging role of NF-kappaB in the resolution of inflammation and some of the potential mechanisms attributed to this function...
  31. ncbi Colectomy rate comparison after treatment of ulcerative colitis with placebo or infliximab
    William J Sandborn
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
    Gastroenterology 137:1250-60; quiz 1520. 2009
    ..The efficacy of infliximab for treating patients with ulcerative colitis has been established...
  32. ncbi Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area
    Christopher M Booth
    University of Toronto, Mount Sinai Hospital, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    JAMA 289:2801-9. 2003
    ..Severe acute respiratory syndrome (SARS) is an emerging infectious disease that first manifested in humans in China in November 2002 and has subsequently spread worldwide...
  33. ncbi Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: lack of association between antioxidant and lipoxygenase inhibitory activity
    Wai Mun Loke
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Biochem Pharmacol 75:1045-53. 2008
    ....
  34. ncbi Study of antirestenosis with the BiodivYsio dexamethasone-eluting stent (STRIDE): a first-in-human multicenter pilot trial
    Xiaoshun Liu
    Department of Cardiology, University Hospitals Leuven, Leuven, Belgium
    Catheter Cardiovasc Interv 60:172-8; discussion 179. 2003
    ..0.60 +/- 0.55 mm, P < 0.07, and 26.86 +/- 14 vs. 38.40 +/- 16%, P < 0.02). This study demonstrated the feasibility and safety of the implantation of a dexamethasone-eluting stent and its effect on in-stent neointimal hyperplasia...
  35. pmc Short course prednisolone for adhesive capsulitis (frozen shoulder or stiff painful shoulder): a randomised, double blind, placebo controlled trial
    R Buchbinder
    Monash Department of Clinical Epidemiology, Cabrini Hospital, Melbourne, Australia
    Ann Rheum Dis 63:1460-9. 2004
    ..To determine whether a short course of prednisolone is superior to placebo for improving pain, function, and range of motion in adhesive capsulitis...
  36. ncbi Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model
    Takukyu Sha
    Pharmacology Research Laboratories I, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 17 85, Jusohonmachi 2 chome, Yodogawa ku, Osaka 532 8686, Japan
    Eur J Pharmacol 571:231-9. 2007
    ..TAK-242 has a quick onset of action and provides significant benefits by post-treatment, suggesting that it may be a promising drug candidate for the treatment of sepsis...
  37. ncbi Infliximab prevents Crohn's disease recurrence after ileal resection
    Miguel Regueiro
    Inflammatory Bowel Disease Center and Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Gastroenterology 136:441-50.e1; quiz 716. 2009
    ..Crohn's disease commonly recurs after intestinal resection. We evaluated whether the administration of infliximab after resective intestinal surgery for Crohn's disease reduces postoperative recurrence...
  38. ncbi Bronchodilator reversibility, airway eosinophilia and anti-inflammatory effects of inhaled fluticasone in COPD are not related
    David W Reid
    Respiratory Research Group, Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Respirology 13:799-809. 2008
    ..In particular, it is not known whether BDR is associated with underlying airway eosinophilia and whether BDR is predictive of a better response to inhaled corticosteroid (ICS) treatment...
  39. ncbi Ocular pharmacokinetics of fluocinolone acetonide after Retisert intravitreal implantation in rabbits over a 1-year period
    Jean Yves Driot
    Bausch and Lomb, Montpellier, France
    J Ocul Pharmacol Ther 20:269-75. 2004
    ..The present study was designed to examine the pharmacokinetics of a fluocinolone acetonide (FA) intravitreal implant in pigmented rabbits...
  40. pmc Airways inflammation and treatment during acute exacerbations of COPD
    Erik Bathoorn
    Groningen Research Institute for Asthma and COPD GRIAC, Department of Pulmonology, University Medical Center Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 3:217-29. 2008
    ..It is important to focus on inflammation since it gives insight into the pathological changes causing an exacerbation, thereby possibly providing directions for future therapies which modify inflammation...
  41. ncbi Antibiotics and topical nasal steroid for treatment of acute maxillary sinusitis: a randomized controlled trial
    Ian G Williamson
    Department of Medicine, University of Southampton, Southampton, England
    JAMA 298:2487-96. 2007
    ..Acute sinusitis is a common clinical problem that usually results in a prescription for antibiotics but the role of antibiotics is debated. Anti-inflammatory drugs such as topical steroids may be beneficial but are underresearched...
  42. ncbi Antiinflammatory effect of A3 adenosine receptor agonists in murine autoimmune arthritis models
    Ehud Baharav
    Can Fite BioPharma Ltd, 10 Bareket Street, Kiryat Matalon, Petach Tikva, Tel Aviv, Israel 49170
    J Rheumatol 32:469-76. 2005
    ..We evaluated its therapeutic potential and antiinflammatory effects in 3 murine models of adjuvant induced arthritis (AIA)...
  43. ncbi Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes
    Josbert M Metselaar
    Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands
    Arthritis Rheum 48:2059-66. 2003
    ....
  44. ncbi Cyclic pamidronate infusion improves bone mineralisation and reduces fracture incidence in osteogenesis imperfecta
    Y S Lee
    Department of Paediatrics, National University of Singapore, National University Hospital, Singapore
    Eur J Pediatr 160:641-4. 2001
    ..This may represent a net reduction in bone resorption and provides a biochemical explanation for the increase in bone mineralisation. Height standard deviation scores were not affected and there were no significant adverse effects...
  45. ncbi Anti-inflammatory effects of macrolides--an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions?
    G W Amsden
    The Clinical Pharmacology Research Center and Department of Adult and Pediatric Medicine, Bassett Healthcare, Cooperstown, NY, USA
    J Antimicrob Chemother 55:10-21. 2005
    ....
  46. pmc Role of p38 MAP kinase in LPS-induced airway inflammation in the rat
    E B Haddad
    Pharmacology Department, Aventis Pharma, Rainham Road South, Dagenham, Essex RM10 7XS
    Br J Pharmacol 132:1715-24. 2001
    ..This data may suggest a role for p38 inhibitors in the treatment of airway inflammatory diseases in which neutrophilia is a feature of the lung pathology...
  47. ncbi A scoring index for disease activity in canine inflammatory bowel disease
    Albert E Jergens
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    J Vet Intern Med 17:291-7. 2003
    ..We conclude that the CIBDAI is a reliable measure of inflammatory activity in canine IBD and that CRP is suitable for laboratory evaluation of the effect of therapy in these patients...
  48. ncbi A long-term study of the antiinflammatory effect of low-dose budesonide plus formoterol versus high-dose budesonide in asthma
    J C Kips
    Department of Respiratory Diseases, University Hospital Ghent, Ghent, Belgium
    Am J Respir Crit Care Med 161:996-1001. 2000
    ..In conclusion, no significant differences in sputum markers of airway inflammation were observed during a 1-yr treatment with a low dose of inhaled budesonide plus formoterol compared with a higher dose of budesonide...
  49. ncbi The role of nuclear factor kappa B in the pathogenesis of pulmonary diseases: implications for therapy
    Jeffrey G Wright
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 27232 2650, USA
    Am J Respir Med 2:211-9. 2003
    ..The complex NF-kappaB pathway offers a variety of potential molecular targets for chemotherapeutic intervention. A variety of agents aimed at modulating NF-kappaB activity are in various stages of investigation...
  50. ncbi Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future
    Kian Fan Chung
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW36LY, UK
    Eur J Clin Pharmacol 65:853-71. 2009
    ..Other agents that could improve the efficacy of corticosteroids or reverse corticosteroid insensitivity may be added to ICS. ICS in combination with LABAs will continue to remain the main focus of treatment of airways diseases...
  51. ncbi Effect of montelukast on lung function in asthma patients with allergic rhinitis: analysis from the COMPACT trial
    D B Price
    Department of General Practice and Primary Care, University of Aberdeen, Foresterhill Health Centre, Aberdeen UK
    Allergy 61:737-42. 2006
    ..This analysis was designed to examine whether asthmatic patients with comorbid AR respond differently than patients without comorbid AR in terms of asthma control (lung function)...
  52. ncbi Metronidazole in the treatment of chronic radiation proctitis: clinical trial
    J Cavcic
    Department of Surgery, Zagreb University Hospital Center, Kispaticeva 12, 10000 Zagreb, Croatia
    Croat Med J 41:314-8. 2000
    ..To evaluate the effectiveness of metronidazole in combination with corticosteroids in enema and mesalazine (5-aminosalicylic acid) in comparison with the same protocol without metronidazole in the treatment of chronic radiation proctitis...
  53. ncbi Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial
    G U Meduri
    Baptist Memorial Hospitals, Veterans Affairs Medical Center, University of Tennessee, Memphis, USA
    JAMA 280:159-65. 1998
    ..No pharmacological therapeutic protocol has been found effective in modifying the clinical course of acute respiratory distress syndrome (ARDS) and mortality remains greater than 50%...
  54. ncbi Anti-inflammatory activity of hexane leaf extract of Aspilia africana C.D. Adams
    C O Okoli
    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
    J Ethnopharmacol 109:219-25. 2007
    ..The terpenoids present in the leaves may account for the anti-inflammatory activity...
  55. ncbi Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages
    Erik S Musiek
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 280:35562-70. 2005
    ..These findings suggest that cyclopentenone IsoPs may serve as negative feedback regulators of inflammation and have important implications for defining the role of oxidative stress in the inflammatory response...
  56. pmc Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome
    C K Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Exp Immunol 136:95-103. 2004
    ....
  57. pmc Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor
    Mauro Perretti
    1 Department of Biochemical Pharmacology, William Harvey Research Institute, Bart s and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London, UK 2 M P and N C contributed equally to this paper
    Nat Med 8:1296-302. 2002
    ....
  58. ncbi Induction of regulatory dendritic cells by dexamethasone and 1alpha,25-Dihydroxyvitamin D(3)
    Anders Elm Pedersen
    Department of Medical Anatomy A, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Immunol Lett 91:63-9. 2004
    ..Thus, D(3)/Dex is an effective immunosuppressive drug combination for the induction of DCs capable of inducing T cell hyporesponsiveness...
  59. ncbi Mycophenolate mofetil for the treatment of uveitis
    Stephen C Teoh
    Bristol Eye Hospital, University of Bristol, Bristol, UK
    Am J Ophthalmol 146:752-60, 760.e1-3. 2008
    ....
  60. ncbi Structural and functional brain development after hydrocortisone treatment for neonatal chronic lung disease
    Gregory A Lodygensky
    Department of Pediatrics, University of Geneva, 6 Rue Willy Donze, 1211 Geneva, Switzerland
    Pediatrics 116:1-7. 2005
    ....
  61. ncbi A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. The Loteprednol Etabonate Giant Papillary Conjunctivitis Study Group I
    M H Friedlaender
    Scripps Clinic Medical Group, Inc, La Jolla, California 92037, USA
    Am J Ophthalmol 123:455-64. 1997
    ..To evaluate the safety and effectiveness of loteprednol etabonate 0.5% ophthalmic suspension in reducing the ocular signs and symptoms accompanying contact lens-associated giant papillary conjunctivitis...
  62. pmc Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients
    Emmanuel Xystrakis
    Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma at King s College London, Strand, London, United Kingdom
    J Clin Invest 116:146-55. 2006
    ..This strongly suggests that vitamin D3 could potentially increase the therapeutic response to glucocorticoids in SR patients...
  63. ncbi Interstitial lung diseases in infants and children
    A Clement
    Respiratory and Allergic Disease Division, Paediatric Dept, Medical University of Graz, Auenbruggerplatz 30, A 8036 Graz, Austria
    Eur Respir J 31:658-66. 2008
    ..The present article reviews interstitial lung disease in infants and children, placing emphasis on current concepts of pathophysiological mechanisms and approaches to treatment...
  64. ncbi Short- and long-term effects of neonatal glucocorticoid therapy: is hydrocortisone an alternative to dexamethasone?
    M van der Heide-Jalving
    Department of Neonatology, University Medical Centre Wilhelmina Children s Hospital, Utrecht, The Netherlands
    Acta Paediatr 92:827-35. 2003
    ..To compare short-term effects and neurodevelopmental outcome of neonatal glucocorticoid therapy between two centres...
  65. ncbi Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study
    Mona R Loutfy
    North York General Hospital, Toronto General Research Institute, Toronto, Ontario
    JAMA 290:3222-8. 2003
    ..Severe acute respiratory syndrome (SARS) is a new clinical entity for which no effective therapeutic strategy has been developed...
  66. ncbi Long-term interleukin 10 therapy in chronic hepatitis C patients has a proviral and anti-inflammatory effect
    David R Nelson
    Department of Medicine, University of Florida, 1600 S W Archer Road, PO Box 100214, Gainesville, FL 32610 0214, USA
    Hepatology 38:859-68. 2003
    ..In conclusion, long-term rIL-10 therapy appears to decrease disease activity, but also leads to increased HCV viral burden via alterations in immunologic viral surveillance...
  67. pmc Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis
    J M Metselaar
    Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences, The Netherlands
    Ann Rheum Dis 63:348-53. 2004
    ....
  68. ncbi Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor
    Sarah X Zhang
    Department of Medicine Endocrinology, Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    FASEB J 20:323-5. 2006
    ..These findings suggest that PEDF is a novel endogenous anti-inflammatory factor in the eye. The decrease of ocular PEDF levels may contribute to inflammation and vascular leakage in DR...
  69. ncbi Intravitreal infliximab in experimental endotoxin-induced uveitis
    Hamid Hosseini
    Department of Ophthalmology, Poostchi Ophthalmic Research Center, Shiraz University of Medical Sciences, Shiraz Iran
    Eur J Ophthalmol 19:818-23. 2009
    ..The aim of this study was to evaluate the effect of intravitreal injection of infliximab on experimental uveitis...
  70. ncbi Cross-talk between pro-inflammatory transcription factors and glucocorticoids
    I M Adcock
    Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Science, Technology and Medicine, London, United Kingdom
    Immunol Cell Biol 79:376-84. 2001
    ..This suggests that cross-talk between pro- and anti-inflammatory transcription factors may modulate activation of the transcriptional complex and thereby reduce steroid actions...
  71. pmc Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression
    Kavon Rezai-Zadeh
    Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    J Neuroinflammation 5:41. 2008
    ..In particular, flavonoids, apigenin and luteolin have been found to be effective CD40 immunomodulators...
  72. ncbi Effectiveness of fluticasone propionate and salmeterol combination delivered via the Diskus device in the treatment of chronic obstructive pulmonary disease
    Donald A Mahler
    Dartmouth Hitchcock Medical Center, Section of Pulmonary and Critical Care Medicine, 1 Medical Center Drive, Lebanon, NH 03756 0001, USA
    Am J Respir Crit Care Med 166:1084-91. 2002
    ..We conclude that FSC improved lung function and reduced the severity of dyspnea compared with individual components and placebo...
  73. ncbi Pathophysiology of polytrauma
    Marius Keel
    Division of Trauma Surgery, University Hospital Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    Injury 36:691-709. 2005
    ..However, the development of immunomonitoring will help in the selection of patients at risk of post-traumatic complications and, thereby, the choice of the most appropriate treatment protocols for severely injured patients...
  74. ncbi Low-dose fluticasone propionate compared with montelukast for first-line treatment of persistent asthma: a randomized clinical trial
    W Busse
    University of Wisconsin-Madison Medical School, USA
    J Allergy Clin Immunol 107:461-8. 2001
    ..CONCLUSIONS: Low-dose FP is more effective than montelukast as first-line maintenance therapy for patients with persistent asthma who are undertreated and remain symptomatic while taking short-acting beta2-agonists alone...
  75. ncbi Anti-inflammatory bioactivities in plant extracts
    R S Talhouk
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    J Med Food 10:1-10. 2007
    ..For this aim, the reported literature of five plant genera assumed to possess anti-inflammatory bioactivities and typically prescribed by folk doctors to treat inflammation-related ailments is reviewed...
  76. ncbi Caffeic acid phenethyl ester (CAPE) prevents inflammatory stress in organotypic hippocampal slice cultures
    Pascale Montpied
    Faculte de Pharmacie, CNRS UMR 5094, 15 Avenue Charles Flahault, 34060 Montpellier Cedex 2, France
    Brain Res Mol Brain Res 115:111-20. 2003
    ....
  77. ncbi In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist
    F W Birke
    Department of Pulmonary Research, Boehringer Ingelheim Pharma, KG D 55216 Ingelheim am Rhein, Germany
    J Pharmacol Exp Ther 297:458-66. 2001
    ..BIIL 284 is an unusually potent and long-acting orally active LTB(4) antagonist, and is therefore under clinical development as a novel anti-inflammatory principle...
  78. pmc Endotoxin neutralization and anti-inflammatory effects of tobramycin and ceftazidime in porcine endotoxin shock
    Gunilla Goscinski
    Section of Infectious Diseases, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Crit Care 8:R35-41. 2004
    ..The aim of the present study was to investigate whether the biological effects of endotoxin in a porcine model could be neutralized by tobramycin, and whether tobramycin or ceftazidime was able to modulate the inflammatory response...
  79. ncbi The role of glial reaction and inflammation in Parkinson's disease
    E C Hirsch
    INSERM U289, Experimental Neurology and Therapeutics, Hopital de la Salpetriere, 75651 Paris Cedex 13, France
    Ann N Y Acad Sci 991:214-28. 2003
    ..Inhibition of the glial reaction and the inflammatory processes may thus represent a therapeutic target to reduce neuronal degeneration in Parkinson's disease...
  80. ncbi Validation of the human ozone challenge model as a tool for assessing anti-inflammatory drugs in early development
    Olaf Holz
    Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Wohrendamm 80, D 22927 Grosshansdorf, Germany
    J Clin Pharmacol 45:498-503. 2005
    ..The authors conclude that an optimized ozone challenge model (including ozone responders and ensuring adequate drug levels during exposure) may be useful for testing novel anti-inflammatory compounds in early development...
  81. ncbi High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome
    James C Ho
    University Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, People s Republic of China
    Am J Respir Crit Care Med 168:1449-56. 2003
    ....
  82. ncbi Posterior subtenon and intravitreal triamcinolone acetonide for diabetic macular edema
    Sengul Ozdek
    Ophthalmology Department, School of Medicine, Gazi University, Besevler, Ankara, Turkey
    J Diabetes Complications 20:246-51. 2006
    ..To evaluate retroprospectively the clinical consequences of posterior subtenon (PSTT) and intravitreal (IVT) triamcinolone acetonide injections in diabetic macular edema (DME) refractory to conventional grid laser photocoagulation...
  83. pmc Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epithelial cells: possible role in the signaling pathway that regulates nuclear factor-kappaB activation
    Masashi Desaki
    Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine Kitasato Medical Institute, Tokyo, Japan
    Antimicrob Agents Chemother 48:1581-5. 2004
    ..Taken together, these data suggest EM has an anti-inflammatory action, presumably via an interaction with the NF-kappaB signaling pathway in the downstream of the dissociation from IkappaB, resulting in the inhibition of NF-kappaB...
  84. ncbi Anti-inflammatory effect of 1-methylnicotinamide in contact hypersensitivity to oxazolone in mice; involvement of prostacyclin
    Krzysztof Bryniarski
    Department of Immunology Jagiellonian University Medical College, Krakow, Poland
    Eur J Pharmacol 578:332-8. 2008
    ..Accordingly, our results demonstrate for the first time that anti-inflammatory properties of MNA are linked to endothelial, PGI(2)-mediated mechanisms...
  85. ncbi Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor?
    Robert Newton
    Department of Cell Biology and Anatomy, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada
    Mol Pharmacol 72:799-809. 2007
    ..Considerable care is therefore required to avoid loss of anti-inflammatory effectiveness in the development of novel transactivation-defective ligands of GR...
  86. pmc Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease
    C E Brightling
    Institute for Lung Health, Clinical Sciences Wing, University Hospitals of Leicester, Groby Road, Leicester LE3 9QP, UK
    Thorax 60:193-8. 2005
    ..Whether the response to inhaled corticosteroids is related to the presence of eosinophilic inflammation is unclear...
  87. ncbi Analysis of the inflammatory response in the rat paw caused by the venom of Apis melifera bee
    M C Calixto
    Department of Pharmacology, Centre of Biological Sciences, Universidade Federal de Santa Catarina, Rua Ferreira Lima, 82, Florianopolis, SC, 88015 420, Brazil
    Inflamm Res 52:132-9. 2003
    ..This study examines the pro-inflammatory action caused by subcutaneous (s.c.) injection of the bee venom (BV) Apis melifera in the rat paw...
  88. ncbi Heterogeneity of FeNO response to inhaled steroid in asthmatic children
    F Buchvald
    Department of Paediatrics, Rigshospitalet, National University Hospital, Copenhagen, Denmark
    Clin Exp Allergy 33:1735-40. 2003
    ..Nitric oxide in exhaled air is regarded as an inflammation marker, and may be used to monitor the anti-inflammatory control from inhaled corticosteroids (ICSs). However, this response to ICSs exhibits a heterogeneous pattern...
  89. ncbi Efficacy of adalimumab in the treatment of axial spondylarthritis without radiographically defined sacroiliitis: results of a twelve-week randomized, double-blind, placebo-controlled trial followed by an open-label extension up to week fifty-two
    Hildrun Haibel
    Charité Medical University Hospital, Campus Benjamin Franklin, Berlin, Germany
    Arthritis Rheum 58:1981-91. 2008
    ..To evaluate the efficacy and safety of the tumor necrosis factor (TNF) antagonist adalimumab in patients with axial spondylarthritis (SpA) without radiographically defined sacroiliitis refractory to conventional treatment...
  90. ncbi Structure-activity relations of inhibitory effects of various flavonoids on lipopolysaccharide-induced prostaglandin E2 production in rat peritoneal macrophages: comparison between subclasses of flavonoids
    Y Takano-Ishikawa
    National Food Research Institute, Kannondai, Tsukuba, Ibaraki, Japan
    Phytomedicine 13:310-7. 2006
    ..Flavonoids showed the strongest inhibitory effect on the expression of Cox-2 protein. These results help to explain part of the reason for the pharmacological efficacy of flavonoids as anti-inflammatory compounds...
  91. pmc The PI3K-NF-kappaB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant-induced arthritis
    Pnina Fishman
    Can Fite BioPharma Ltd, Kiryat Matalon, Petah Tikva, Israel
    Arthritis Res Ther 8:R33. 2006
    ..The finding that the A3AR expression level in the peripheral blood mononuclear cells and in the DLN reflects the receptor status in the remote inflammatory site suggests use of the A3AR as a follow-up biomarker...
  92. ncbi Placebo-controlled trial of prednisone in advanced HIV-1 infection
    G A McComsey
    Case Western Reserve University and University Hospitals of Cleveland, Ohio, USA
    AIDS 15:321-7. 2001
    ..These results suggest that, in stable HIV-1 disease, these immune activation markers are more likely consequences of but not inducers of HIV-1 replication...
  93. ncbi Inhibition of nitric oxide synthase expression by a methanolic extract of Crescentia alata and its derived flavonols
    G Autore
    Department of Pharmaceutical Sciences, University of Salerno, Fisciano-Salerno, Italy
    Life Sci 70:523-34. 2001
    ..A1 cells, whereas rutin (1) and kaempferol 3-O-rutinoside (2) showed no significant activity. The MeOH extract and all of flavonoids tested did not show in vitro significant cytotoxic effect in J774.A1 macrophage cell line...
  94. ncbi An effective and more convenient drug regimen for prophylaxis against paclitaxel-associated hypersensitivity reactions
    M Markman
    Department of Hematology Medical Oncology, The Cleveland Clinic Foundation, Ohio 44195, USA
    J Cancer Res Clin Oncol 125:427-9. 1999
    ....
  95. ncbi Focal small bowel perforation: an adverse effect of early postnatal dexamethasone therapy in extremely low birth weight infants
    P V Gordon
    Department of Pediatrics, University of North Carolina at Chapel Hill, 27599-7596, USA
    J Perinatol 21:156-60. 2001
    ..61, indicating homogeneity among the studies. FSBP was significantly higher in EPD treated infants [odds ratio 1.91, 95% confidence interval (CI) 1.21, 3.07; p=0.004]. CONCLUSION: EPD increases the risk of FSBP in ELBW infants...
  96. ncbi Effects of adalimumab maintenance therapy on health-related quality of life of patients with Crohn's disease: patient-reported outcomes of the CHARM trial
    Edward V Loftus
    Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 103:3132-41. 2008
    ..We evaluated the effects of adalimumab maintenance therapy on health-related quality of life (HRQOL) in patients with moderate to severe Crohn's disease...
  97. ncbi Inhaled corticosteroids and the risk of mortality and readmission in elderly patients with chronic obstructive pulmonary disease
    D D Sin
    The Institute for Clinical Evaluative Sciences and The Department of Medicine, Sunnybrook and Women s College Health Science Center, University of Toronto, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 164:580-4. 2001
    ....
  98. ncbi Long-term effects of intravenous high dose methylprednisolone pulses on bone mineral density in patients with multiple sclerosis
    M Zorzon
    Department of Clinical Medicine and Neurology, University of Trieste, Cattinara Hospital, Trieste, Italy
    Eur J Neurol 12:550-6. 2005
    ..BMD should be monitored in patients with MS, regardless of the use of methylprednisolone...
  99. ncbi Antiinflammatory action of glucocorticoids--new mechanisms for old drugs
    Turk Rhen
    Department of Biology, University of North Dakota, Grand Forks, USA
    N Engl J Med 353:1711-23. 2005
  100. ncbi The impact of inhaled corticosteroid and long-acting beta-agonist combination therapy on outcomes in COPD
    Nicola A Hanania
    Section of Pulmonary and Critical Care Medicine, Asthma Clinical Research Center, Baylor College of Medicine, 1504 Taub Loop, Houston, TX 77030, USA
    Pulm Pharmacol Ther 21:540-50. 2008
    ....
  101. ncbi Studies on the anti-inflammatory and analgesic activity of Curatella americana L
    M S Alexandre-Moreira
    Laboratorio de Tecnologia Farmaceutica, Universidade Federal da Paraiba, Joao Pessoa, Brazil
    J Ethnopharmacol 67:171-7. 1999
    ..The HAE has shown both anti-inflammatory and peripheral analgesic activities when administrated in the mouse by the intraperitoneal route in doses which are at least 12 times lower than its LD50 dose of 647 mg/kg, i.p...

Research Grants73

  1. Reactive (AA)Amyloidosis
    Merrill D Benson; Fiscal Year: 2013
    ..Understanding the pathogenesis of the reactive form of amyloidosis may reveal avenues for treatment of not only AA amyloidosis but also other forms of amyloidosis in the Veteran population. ..
  2. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..Successful completion of the study will lead to improved health outcome of a significant number of patients by decreasing the need for indefinite use of non-specific immunosuppressants in transplant recipients. ..
  3. Targeting Inflammation for the Amelioration of Cisplatin-Hearing Loss
    Vickram Ramkumar; Fiscal Year: 2011
    ..We believe the information gained from this study will lead to potentially new treatments for treating hearing loss. ..
  4. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011
    ....
  5. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
    ....
  6. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2013
    ....
  7. PROSPECTIVE STUDIES OF DIET AND CANCER IN MEN AND WOMEN
    Walter C Willett; Fiscal Year: 2010
    ..The findings will contribute importantly to the prevention and prognosis of major cancers of men and women. ..
  8. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2010
    ..The objective of this application is to evaluate a lead small- molecule drug candidate in two preclinical models of scleroderma/SSc to advance to SBIR Phase-II project with the ultimate objective of bringing our drug to clinical trials. ..
  9. Discovery of Novel Anti-Inflammatory Phytochemicals on Human Cell Platforms
    ERIK MILLS SCHWIEBERT; Fiscal Year: 2010
    ..This DBM-led partnership seeks to lead a new renaissance in complementary and alternative medicine (CAM) research for new global anti-inflammatory drugs with this long-term and closely held scientific and commercial vision. ..
  10. REGULATION OF NF-KAPPA B
    INDER MOHAN VERMA; Fiscal Year: 2013
    ..We propose to study the molecular mechanism of inflammatory processes by studying the regulation of NF-?B a seminal molecule in the induction of inflammation. ..
  11. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2013
    ..We will also evaluate the safety/toxicology profile of ANG3070, in order to assemble a complete IND-enabling preclinical data package to submit to FDA for advancing to human studies. ..
  12. A Prospective Study of Diet and Prostate Cancer
    Edward Giovannucci; Fiscal Year: 2011
    ..abstract_text> ..
  13. Established Investigator Award Anti-Inflammatory Exposures in Cancer Prevention
    Emily White; Fiscal Year: 2013
    ..To accomplish this, the applicant will reduce her large administrative responsibilities, including stepping down from her role as Associate Dean for Research in the University of Washington School of Public Health. ..
  14. Counter-Regulatory Lipid Mediators in Lung Disease
    Bruce D Levy; Fiscal Year: 2012
    ..abstract_text> ..
  15. Searching for Novel Analgesic and Anti-inflammatory Agents
    Guigen Li; Fiscal Year: 2010
    ..The present NIH-R15 grant will greatly benefit PI's undergraduate and graduate education and help the PI to attract more students into sciences. ..
  16. PKD Family Kinase Function and Signaling in Lung Fibroblasts
    Hua Tang; Fiscal Year: 2012
    ..abstract_text> ..
  17. Antimicrobial and Regenerative Treatment for Oral Mucositis
    SHENDA BAKER; Fiscal Year: 2012
    ..This funding supports an effort to develop an FDA approved daily oral treatment that prevents bacterial infection and complications in mucositis while actively promoting healing and resolution of the oral lesions. ..
  18. Using a cyclotide-based molecular scaffold to select specific protein-protein inh
    Mark W Nowak; Fiscal Year: 2010
    ..Specifically, small molecule drugs that block the binding interaction of NEMO to IKK[unreadable] inhibit NF?B signaling could be developed as anti-inflammatory drugs. ..
  19. Characterization of persistent hyperemic foci and their role in photocarcinogenes
    Raymond L Konger; Fiscal Year: 2013
    ....
  20. Novel Small Molecule Agonists of Integrin CD11b/CD18 as Anti-Inflammatory Agents
    Vineet Gupta; Fiscal Year: 2013
    ....
  21. KLF2, monocyte activation and vascular inflammation
    MUKESH KUMAR JAIN; Fiscal Year: 2013
    ..The results of these studies may also provide the foundation for novel therapies directed at the treatment of a broad spectrum of chronic inflammatory disorders. ..
  22. Protection of Mice From Lethal Alphavirus Encephalitis
    David N Irani; Fiscal Year: 2010
    ....
  23. Development of inlammasome inhibitors to be used as anti-inflammatory agents
    Shyam Biswal; Fiscal Year: 2013
    ..Successful completion of the proposed study will yield novel compounds that inhibit the inflammasome in cell-based systems. ..
  24. VASCULAR ANTI-INFLAMMATORY ACTIONS OF HSP90 INHIBITORS
    John D Catravas; Fiscal Year: 2013
    ..Because these drugs have finished Phase II clinical trials and exhibit low side effects translation of these findings from these studies in cardiovascular disease should be expeditious. ..
  25. Neurodegeneration in multiple sclerosis: Effects of mitochondrial dysfunction and
    KIMMY GER WEN SU; Fiscal Year: 2013
    ..abstract_text> ..
  26. Novel Strategies for prevention of diabetic vascular dysfunction.
    ANDREW LEE MELLOR; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Understanding the molecular mechanisms responsible for development of vascular disease in type 2 diabetes is necessary for successful treatment and prevention. ..
  27. Regulation of inflammatory responses by nucleic-acid binding polymers
    EDUARTA K HOLL; Fiscal Year: 2013
    ..abstract_text> ..
  28. Regulation and Role of Ceramidase in Inflammation
    Lina M Obeid; Fiscal Year: 2013
    ....
  29. New therapeutics for Shiga toxin-E. coli disease.
    Fumiko Obata; Fiscal Year: 2011
    ..This project brings together medical scientists, chemists, and physicians from leading academic research centers and biotechnology industry in an effort to make available new and effective treatments for STEC-associated disease. ..
  30. Advanced Engineering Development of a Chronic Retinal Implant
    JOHN L contact WYATT; Fiscal Year: 2010
    ..abstract_text> ..
  31. The Fibrosis-Lymphedema Continuum in Head and Neck Cancer
    Sheila H Ridner; Fiscal Year: 2013
    ..interventional research (e.g. anti-inflammatory agents);] and 4) assist physicians and other healthcare professionals to better diagnose, reduce risk for, and treat late-effect fibrosis and/or lymphedema. ..
  32. Volumetric imaging of blood perfusion and tissue morphology in the cochlea
    Ruikang Wang; Fiscal Year: 2013
    ..We will correlate the data obtained from use of the instrument with that obtained by high field strength MRI. The project design also includes a clinical arm that aims to translate the technique into the clinical settings. ..
  33. TRANSPORT ACROSS CAPILLARY ENDOTHELIUM
    Fitz Roy E Curry; Fiscal Year: 2013
    ....
  34. BLOOD CELL LIPOXYGENASE PRODUCTS--FORMATION AND ACTION
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2013
    ....
  35. Obesity associated inflammation and postmenopausal breast cancer.
    ERIN GILES; Fiscal Year: 2013
    ..Use of anti-inflammatory agents, in conjunction with standard obesity treatments like as caloric restriction or exercise, has the potential to reduce obesity-associated risk and improve clinical outcomes. ..
  36. Mitochondrial Genetics in Prostate Cancer Health Disparity
    John A Petros; Fiscal Year: 2012
    ....
  37. Reactivation of breast cancer micrometastases by senescent bone marrow stroma
    Robert Wieder; Fiscal Year: 2010
    ..Experiments will determine if treatment with estrogen or anti-inflammatory agents can restore the capacity of senescent stroma to support dormancy. ..
  38. Mechanisms of PARP and PARG mediated cell death
    Raymond A Swanson; Fiscal Year: 2013
    ....
  39. Chloride secretagogues for acquired CFTR dysfunction in chronic rhinosinusitis
    Bradford Alan Woodworth; Fiscal Year: 2013
    ....
  40. A Novel Class of Therapeutic Agents for the Treatment of Skin Diseases Associated
    Joel S Gordon; Fiscal Year: 2010
    ..g. atopic dermatitis, seborrheic dermatitis). ..
  41. Nsaid Effects on Clinical and Imaging Breast Biomarkers
    PATRICIA ANN THOMPSON; Fiscal Year: 2013
    ..Success in this phase II biomarker trial of sulindac combined with AI will serve as justification for a larger trial with cancer specific outcomes. ..
  42. Omega-3 Fatty Acid Effects on Pancreatitis and Adenocarcinoma Development
    Christopher A Jolly; Fiscal Year: 2013
    ..This data may show an important role for the omega-3 PUFAs, especially EPA, in cancer prevention because they are well known anti-inflammatory agents and are widely consumed by people in the United States. ..
  43. Controlling cancer with aspirin-triggered stimulation of resolution
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2013
    ....
  44. Bridging multiple scales in modeling targeted drug nanocarrier delivery
    Ravi Radhakrishnan; Fiscal Year: 2013
    ..Our modeling and experimental approaches will enable us to develop and bridge multiscale techniques for clinical translation. ..
  45. Biosynthesis of Polysaccharides
    Peng George Wang; Fiscal Year: 2012
    ....
  46. MORPHINE ACTIONS ON THE IMMUNE SYSTEM
    Sulie L Chang; Fiscal Year: 2012
    ..abstract_text> ..
  47. Mechanisms of Triterpenoids in Prevention of Prostate Cancer
    Subhash C Gautam; Fiscal Year: 2011
    ....
  48. Biophysical Basis of Organization and Dynamics of Prestin Membrane Complexes
    Robert M Raphael; Fiscal Year: 2013
    ....
  49. Alcohol Injury Healing, Cytoprotection and Survivin
    Michael Jones; Fiscal Year: 2009
    ..Information gained from these studies will lead to better understanding of the mechanisms underlying ETOH-induced injury and will provide for the development of better therapeutics for treating ETOH-induced injury. ..
  50. Resolution of Cytokine-Mediated Salivary Gland Inflammation
    OLGA JULIANA BAKER; Fiscal Year: 2013
    ..We believe a better understanding of RvD1 biogenesis, signaling, and treatment could reduce the progress of SS in earlier stage patients and lead to improved symptom management for advanced stage patients. ..
  51. Combinational regulation of inflammation in otitis media
    Jian dong Li; Fiscal Year: 2013
    ..Overall, the proposed studies will advance our understanding of molecular pathogenesis of OM and lead to identifying novel therapeutic targets and new anti-inflammatory agents for OM. ..
  52. CXCL16/CXCR6 and Their Roles in Autoimmune Arthritis
    Shuhua Han; Fiscal Year: 2010
    ..The study will also provide insights into new targets for designing anti-inflammatory agents in autoimmune arthritis and other autoimmune diseases ..
  53. Rhythmicity and Synchrony in the Basal Ganglia
    DALTON JAMES SURMEIER; Fiscal Year: 2013
    ....
  54. Why Are Steroids Ineffective at Suppressing RSV Bronchiolitis
    Raymond J Pickles; Fiscal Year: 2013
    ..These studies will provide a novel platform for developing and testing therapeutics for relieving the onset and severity of RSV bronchiolitis in humans. ..
  55. Imaging and Treating Inflammation in Stroke by Targeting Myeloperoxidase
    John W Chen; Fiscal Year: 2013
    ....
  56. Vitamin D3 alters stromal-epithelial inflammatory crosstalk in human prostate
    Larisa Nonn; Fiscal Year: 2013
    ..We propose a bedside-to-bench approach to first quantify the key genes and microRNAs in stromal tissue then assess these inflammatory mediators in a relevant in vitro model. ..
  57. Targeting Muller Cells to Treat Optic Nerve Injury
    Sherry Ball; Fiscal Year: 2009
    ..Positive results will be further explored to develop optimal treatment strategies. ..
  58. Nitric Oxide Chimera Drugs for Colon Cancer Chemoprevention
    Gregory R J Thatcher; Fiscal Year: 2012
    ..Completion of these aims will yield new drug candidates for CRC chemoprevention and improved understanding of chemopreventive pathways in CRC. ..
  59. An animal model for age-related degeneration
    ANN CHARLOTTE ESTHER GRANHOLM; Fiscal Year: 2010
    ..The overall purpose of these studies is to investigate endogenous defense mechanisms as well as the degenerative process in itself, to explore if early intervention strategies can be employed. ..
  60. SIGN receptors and the antiinflammatory activity of sialylated IgG Fcs
    ROBERT MCCULLOUGH ANTHONY; Fiscal Year: 2013
    ....
  61. Clinical Evaluation of GI Safer Naproxen for the Treatment of Osteoarthritis
    UPENDRA K MARATHI; Fiscal Year: 2010
    ....
  62. Pro-Inflammatory Cytokine Glucocorticoid Resistance in Major Depressive Disorder
    Heather M Burke; Fiscal Year: 2010
    ..g., cardiovascular disease, coronary heart disease, rheumatoid arthritis, multiple sclerosis). ..
  63. ORAL CONTROLLED-RELEASE DELIVERY SYSTEMS
    H Rawls; Fiscal Year: 1991
    ..The results will be used to characterize the rates and durations of release achievable by this system, and will provide the basis for later development of other controlled-release systems...
  64. Bell's Palsy-Randomized Clinical Trial
    John Neely; Fiscal Year: 2007
    ..This revised planning grant application is to support necessary preparation for the multicenter trial. [unreadable] [unreadable] [unreadable]..
  65. Phase III Trial of Minocycline in ALS:I-Clinical Center
    Paul Gordon; Fiscal Year: 2007
    ..P.I. Dr. Robert Miller). ..
  66. XENOBIOTICS, INFLAMMATION AND CARCINOGENESIS
    James Lewis; Fiscal Year: 1991
    ....
  67. REGULATION OF GENE EXPRESSION IN MAMMALIAN CELLS
    Jerry Lingrel; Fiscal Year: 1990
    ..5) To study the role of Alpha1-MAP and kininogens in inflammation. This will be accomplished using an animal model for this response. (6) To determine if a homologous protein to Alpha1-MAP occurs in humans...
  68. MECHANISMS FOR CHEMOPREVENTION OF COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2004
    ..Tissue distribution and comparative metabolism studies of curcumin and PEMC will be studied with synthetic [3H] curcumin and [3H]-PEMC in vivo in male F-344 rats. ..
  69. CYTOKINE MODULATION OF INFLAMMATORY BOWEL DISEASE
    GARY VARILEK; Fiscal Year: 2000
    ..Dr. McClain is a highly experienced mentor who has developed a program for Dr. Varilek that will provide the resources, training, and guidance necessary to achieve success. ..
  70. REG OF THE NADPH OXIDASE BY ANTI-INFLAMMATORY AGENTS
    Peter Newburger; Fiscal Year: 2001
    ..Better understanding of the pharmacological regulation of the NADPH oxidase system will provide information to help modulate its expression during inflammation and oxidant-mediated tissue damage. ..
  71. EICOSANOIDS AND NO IN CEREBROVASCULAR THROMBOSIS
    Kenneth Wu; Fiscal Year: 2003
    ..It is intended that this program will enable several laboratories to work individually and together to achieve the highest degree of innovating and productivity. ..
  72. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2009
    ..These studies will provide new insight into the role of TF and the PI3K-Akt pathway in endotoxemia. This information can be used to develop improved therapeutic strategies for the treatment of patients with severe sepsis. ..
  73. Anti-inflammatory Serpin(AAT and Elafin) Gene Transfers*
    Sihong Song; Fiscal Year: 2003
    ..abstract_text> ..