Genomes and Genes
anti infective agents
Summary: Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
Publications272 found, 100 shown here
- Antibacterial resistance worldwide: causes, challenges and responsesStuart B Levy
Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Nat Med 10:S122-9. 2004..Drug resistance presents an ever-increasing global public health threat that involves all major microbial pathogens and antimicrobial drugs...
- Typhoid feverChristopher M Parry
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
N Engl J Med 347:1770-82. 2002
- Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protectionJoaquim Ruiz
Department of Microbiology, Institut Clinic Infeccions i Immunologia, Hospital Clinic, C Villarroel 170, 08036 Barcelona, Spain
J Antimicrob Chemother 51:1109-17. 2003..Recently, mobile elements have also been described, carrying the qnr gene, which confers resistance to quinolones...
- Immunomodulatory effects of quinolonesAxel Dalhoff
Institute for Medical Microbiology and Virology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Germany
Lancet Infect Dis 3:359-71. 2003....
- Characterization of Streptomyces spp. isolated from the sea surface microlayer in the Trondheim Fjord, NorwaySigrid Hakvåg
Department of Biotechnology, Norwegian University of Science and Technology, N 7491 Trondheim, Norway
Mar Drugs 6:620-35. 2008..The results obtained in this study suggest that streptomycetes from the neuston population may be an interesting source for discovery of new antimicrobial agents...
- Antimicrobial peptides from ranid frogs: taxonomic and phylogenetic markers and a potential source of new therapeutic agentsJ Michael Conlon
Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666 Al Ain, United Arab Emirates
Biochim Biophys Acta 1696:1-14. 2004....
- Mechanism of adenovirus neutralization by Human alpha-defensinsJason G Smith
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell Host Microbe 3:11-9. 2008..Thus, defensins possess remarkably distinct modes of activity against bacteria and viruses, and their function may provide insights for the development of new antiviral strategies...
- Acceptability of Carraguard vaginal gel use among Thai couplesSara J Whitehead
National Center for HIV, Viral Hepatitis, STDs, and Tuberculosis Prevention proposed, Centers for Disease Control and Prevention, Atlanta, USA
AIDS 20:2141-8. 2006..To evaluate the acceptability of candidate microbicide Carraguard among couples participating in a safety trial...
- Antimicrobial activity of omwaprin, a new member of the waprin family of snake venom proteinsDileep G Nair
Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543
Biochem J 402:93-104. 2007....
- Antimicrobial activity of the leaves and seeds of Bixa orellanaT C Fleischer
Department of Pharmacognosy, Faculty of Pharmacy, K N U S T, Kumasi, Ghana
Fitoterapia 74:136-8. 2003..The ethanolic extracts of the leaves and seeds of Bixa orellana showed a broad spectrum of antimicrobial activity. The activity of the leaf extract was more pronounced...
- Anti-inflammatory effects of moxifloxacin on activated human monocytic cells: inhibition of NF-kappaB and mitogen-activated protein kinase activation and of synthesis of proinflammatory cytokinesTaly Weiss
Department of Cell Biology and Histology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Antimicrob Agents Chemother 48:1974-82. 2004..Its anti-inflammatory properties should be further assessed in clinical settings...
- Fitness cost of fluoroquinolone resistance in Salmonella enterica serovar TyphimuriumEtienne Giraud
Unité Bio Agresseurs, santé, Environnement, Institut National de la Recherche Agronomique, Centre de Recherche de Tours, 37380 Nouzilly, France
J Med Microbiol 52:697-703. 2003....
- Origin of low mammalian cell toxicity in a class of highly active antimicrobial amphipathic helical peptidesAyman Hawrani
Department of Cellular and Molecular Medicine, Bristol University, Bristol BS8 1TD, United Kingdom
J Biol Chem 283:18636-45. 2008..We highlight a significant role for tryptophan in promoting binding of amphipathic helical peptides to neutral bilayers, augmenting the arsenal of strategies to reduce mammalian toxicity in antimicrobial peptides...
- Antimicrobial characterization of human beta-defensin 3 derivativesDavid M Hoover
Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
Antimicrob Agents Chemother 47:2804-9. 2003..aureus and C. albicans. Further, N-terminal deletion mutants of native hBD3 showed diminished activities against S. aureus. Thus, the antimicrobial properties of hBD3 derivatives are determined by both charge and structure...
- Analysis of antimicrobial susceptibility and virulence factors in Helicobacter pylori clinical isolatesAnita Paula Ortiz Godoy
Clinical Pharmacology and Gastroenterology Unit, Sao Francisco University Medical School, Braganca Paulista, SP, Brazil
BMC Gastroenterol 3:20. 2003..In addition, the vacA, iceA, cagA and cagE genotypes of strains isolated from Brazilian patients were determined and associated with clinical data in an effort to correlate these four virulence markers and antibiotic resistance...
- Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infectionsPatricia Komp Lindgren
Department of Cell and Molecular Biology, Microbiology Programme, Biomedical Center, Uppsala University, S 751 24 Uppsala, Sweden
Antimicrob Agents Chemother 47:3222-32. 2003..This correlation suggests that an increased general mutation rate may play a significant role in the development of high-level resistance to fluoroquinolones by increasing the rate of accumulation of rare new mutations...
- Human alpha-defensins inhibit BK virus infection by aggregating virions and blocking binding to host cellsAisling S Dugan
Department of Molecular Biology, Brown University, Providence, Rhode Island 02912, USA
J Biol Chem 283:31125-32. 2008..We also show a novel mechanism whereby HD5 binds to BKV leading to aggregation of virion particles preventing normal virus binding to the cell surface and uptake into cells...
- cDNA sequences of three sheep myeloid cathelicidinsL Bagella
Laboratorio Nazionale Consorzio Interuniversitario Biotechnologie, CIB, Trieste, Italy
FEBS Lett 376:225-8. 1995..5, which appears to be a new member of the Pro- and Arg-rich group of mammalian antimicrobial peptides...
- Functions of antimicrobial peptides in host defense and immunityChristoph Beisswenger
Hospital of the University of Marburg, Department of Internal Medicine, Division of Pulmonary Medicine, Philipps University Marburg, Germany
Curr Protein Pept Sci 6:255-64. 2005..This review summarizes the current knowledge about the basic and applied biology of antimicrobial peptides and discusses features of AMPs in host defense and inflammation...
- Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursorM Zasloff
Proc Natl Acad Sci U S A 84:5449-53. 1987..The sequence of a partial cDNA of the precursor reveals that both peptides derive from a common larger protein. These peptides appear to represent a previously unrecognized class of vertebrate antimicrobial activities...
- Shifting trends in bacterial keratitis in south Florida and emerging resistance to fluoroquinolonesG Alexandrakis
Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA
Ophthalmology 107:1497-502. 2000..To study the distribution, current trends, and patterns of resistance to antimicrobial agents of bacterial keratitis isolates in South Florida...
- Risks factors and prevention of Q fever endocarditisF Fenollar
, Centre Nationale de Recherche Scientifique, , , 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
Clin Infect Dis 33:312-6. 2001..A proper treatment for such patients and a scheduled follow-up should reduce the risk of developing endocarditis...
- Lactoferrin: an important host defence against microbial and viral attackP Valenti
Dipartimento di Medicina Sperimentale, II Universita di Napoli, Italy
Cell Mol Life Sci 62:2576-87. 2005....
- Multifunctional host defense peptides: intracellular-targeting antimicrobial peptidesPierre Nicolas
BIOgenèse des SIgnaux PEptidiques, ER3 UPMC, Universite Pierre et Marie Curie, Paris, France
FEBS J 276:6483-96. 2009..e. Trp and Pro, His, or Arg. Differences in membrane lipid composition, as well as differential lipid recruitment by peptides, may provide a basis for microbial cell killing on one hand, and mammalian cell passage on the other...
- Pharmacokinetics and elimination of moxifloxacin after oral and intravenous administration in manH Stass
Pharma Research Center, Institute of Clinical Pharmacology, Bayer AG, Wuppertal, Germany
J Antimicrob Chemother 43:83-90. 1999..Plasma concentrations of the metabolites were much lower than those of the parent compound. Moxifloxacin was well tolerated with few adverse events and no clinically relevant changes in laboratory values...
- Hepcidin, a urinary antimicrobial peptide synthesized in the liverC H Park
Departments of Medicine and Pathology, UCLA School of Medicine, Los Angeles, California 90059, USA
J Biol Chem 276:7806-10. 2001..Hepcidin may be a vertebrate counterpart of cysteine-rich antimicrobial peptides produced in the fat body of insects...
- Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, ChinaMinggui Wang
Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China
Antimicrob Agents Chemother 47:2242-8. 2003..coli from Shanghai and may contribute to the rapid increase in bacterial resistance to quinolones in China...
- Carrageenan/MIV-150 (PC-815), a combination microbicideJose A Fernández-Romero
Population Council, New York, NY, USA
Sex Transm Dis 34:9-14. 2007....
- Aurelin, a novel antimicrobial peptide from jellyfish Aurelia aurita with structural features of defensins and channel-blocking toxinsTatiana V Ovchinnikova
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho Maklaya Str 16 10, 117997 Moscow, Russia
Biochem Biophys Res Commun 348:514-23. 2006..Aurelin has no structural homology with any previously identified antimicrobial peptides but reveals partial similarity both with defensins and K+ channel-blocking toxins of sea anemones and belongs to ShKT domain family...
- Antibiotics for upper respiratory tract infections: an overview of Cochrane reviewsB Arroll
Department of General Practice and Primary Health Care, University of Auckland, Auckland New Zealand
Respir Med 99:255-61. 2005..The aim of this paper is to review the four Cochrane reviews of antibiotics for upper respiratory tract infections...
- FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testisB Agerberth
Department of Microbiology, Stockholm University, Sweden
Proc Natl Acad Sci U S A 92:195-9. 1995..RNA blot analyses disclosed that the gene for FALL-39 is expressed mainly in human bone marrow and testis...
- Fluoroquinolones and the risk for methicillin-resistant Staphylococcus aureus in hospitalized patientsStephen G Weber
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Emerg Infect Dis 9:1415-22. 2003..4; p <0.0001; ciprofloxacin OR 2.5; p = 0.005) but not MSSA. Exposure to levofloxacin or ciprofloxacin is a significant risk factor for the isolation of MRSA, but not MSSA...
- gyrA mutations associated with fluoroquinolone resistance in eight species of EnterobacteriaceaeL M Weigel
Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Antimicrob Agents Chemother 42:2661-7. 1998..The type and position of amino acid alterations also differed among these six genera. High-level FQ-R frequently was associated with single gyrA mutations in all species of Enterobacteriaceae in this study except E. coli...
- Control of cell selectivity of antimicrobial peptidesKatsumi Matsuzaki
Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
Biochim Biophys Acta 1788:1687-92. 2009..Pros and cons of these approaches are discussed...
- Association of Atopobium vaginae, a recently described metronidazole resistant anaerobe, with bacterial vaginosisMichael J Ferris
Dept of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
BMC Infect Dis 4:5. 2004..The bacterium Atopobium vaginae has been recognized only recently. It is not readily identified by commercial diagnostic kits. Its clinical significance is unknown but it has recently been isolated from a tuboovarian abcess...
- Guidelines for the selection of anti-infective agents for complicated intra-abdominal infectionsJoseph S Solomkin
Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0558, USA
Clin Infect Dis 37:997-1005. 2003
- Human alpha-defensins block papillomavirus infectionChristopher B Buck
Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute NIH, Bethesda, MD 20892 4263, USA
Proc Natl Acad Sci U S A 103:1516-21. 2006....
- A randomized, placebo-controlled trial to assess the safety and acceptability of use of carraguard vaginal gel by heterosexual couples in ThailandPeter H Kilmarx
National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Sex Transm Dis 35:226-32. 2008..To determine the safety and acceptability of use of Carraguard, a carrageenan-derived candidate microbicide gel, during sexual intercourse in women and men...
- Isolation and analysis of bacteria with antimicrobial activities from the marine sponge Haliclona simulans collected from Irish watersJonathan Kennedy
Environmental Research Institute, University College Cork, Cork, Ireland
Mar Biotechnol (NY) 11:384-96. 2009..This study demonstrates that the culturable fraction of bacteria from the sponge H. simulans is diverse and appears to possess much potential as a source for the discovery of new medically relevant biological active agents...
- A major transition in malaria treatment: the adoption and deployment of artemisinin-based combination therapiesAndrea Bosman
World Health Organization, Avenue Appia 20, Geneva, Switzerland
Am J Trop Med Hyg 77:193-7. 2007..Artemisinins as monotherapies are widely available in the private sector of 47 endemic countries, and their consumption will, if unabated, promote resistance to artemisinins and compromise the effectiveness of ACTs...
- Molecular mechanisms of membrane perturbation by antimicrobial peptides and the use of biophysical studies in the design of novel peptide antibioticsK Lohner
Institute of Biophysics and X ray Structure Research, Austrian Academy of Sciences, A 8042 Graz, Austria
Comb Chem High Throughput Screen 8:241-56. 2005..Emphasis is on the role of membrane lipid composition in these processes and in the translocation of antimicrobial peptides...
- The innate immune response of the respiratory epitheliumG Diamond
Department of Anatomy, Cell Biology and Injury Sciences, UMDNJ New Jersey Medical School, Newark 07103, USA
Immunol Rev 173:27-38. 2000..This can lead to increased susceptibility to airway infections...
- CAMP: a useful resource for research on antimicrobial peptidesShaini Thomas
Biomedical Informatics Center of Indian Council of Medical Research, National Institute for Research in Reproductive Health, Mumbai, India
Nucleic Acids Res 38:D774-80. 2010..CAMP will be a useful database for study of sequence-activity and -specificity relationships in AMPs. CAMP is freely available at http://www.bicnirrh.res.in/antimicrobial...
- The inventory of antibiotics in Russian home medicine cabinetsL S Stratchounski
Institute of Antimicrobial Chemotherapy, Smolensk State Medical Academy, Smolensk, Russia
Clin Infect Dis 37:498-505. 2003..8%), intestinal disorders (11.3%), fever (9%), and sore throat (6.8%). According to this study, antibiotics are widely stocked among the general population in Russia, and people use antibiotics in an uncontrolled and imprudent manner...
- Isolation and molecular characterization of nalidixic acid-resistant extraintestinal pathogenic Escherichia coli from retail chicken productsJames R Johnson
Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55417, USA
Antimicrob Agents Chemother 47:2161-8. 2003....
- Comparative analysis of antibiotic and antimicrobial biocide susceptibility data in clinical isolates of methicillin-sensitive Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa between 1989 and 2000R J W Lambert
R2 Scientific, Sharnbrook, Bedfordshire, UK
J Appl Microbiol 97:699-711. 2004..To analyse population minimum inhibitory concentrations (MICs) data from clinical strains of Staphylococcus aureus and Pseudomonas aeruginosa for changes over a 10-year period and to look for correlations between the antimicrobials tested...
- The successful clone: the vector of dissemination of resistance in Streptococcus pneumoniaeK P Klugman
Department of International Health, Rollins School of Public Health, Division of Infectious Diseases, School of Medicine, Emory University, 1518 Clifton Road NE, Room 764, Atlanta, GA 30322, USA
J Antimicrob Chemother 50:1-5. 2002..The molecular basis of resistance to a number of classes of antimicrobials can be used to predict the likelihood of dissemination of the resistance genes...
- Antibiotic resistance among gram-negative bacilli in US intensive care units: implications for fluoroquinolone useMelinda M Neuhauser
Department of Clinical Sciences and Administration, University of Houston College of Pharmacy, Houston, Tex, USA
JAMA 289:885-8. 2003..Previous surveillance studies have documented increasing rates of antimicrobial resistance in US intensive care units (ICUs) in the early 1990s...
- DNA minor groove binders as potential antitumor and antimicrobial agentsPier Giovanni Baraldi
Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, 44100 Ferrara, Italy
Med Res Rev 24:475-528. 2004....
- Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maximaRen Lai
Department of Animal Toxinology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, People s Republic of, Yunnan, China
Peptides 23:427-35. 2002..Peptides in the second group, termed maximins H1, H2, H3 and H4, are homologous with bombinin H peptides. cDNA sequences revealed that one maximin peptide plus one maximin H peptide derived from a common larger protein...
- In vitro susceptibilities of bacterial ocular isolates to fluoroquinolonesA Graves
Santen, Inc, Napa, California 94558, USA
Cornea 20:301-5. 2001..To evaluate and compare the in vitro antimicrobial activity of levofloxacin versus ciprofloxacin and ofloxacin against ocular isolates from patients with bacterial conjunctivitis...
- Tigecycline: first of a new class of antimicrobial agentsWarren E Rose
Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
Pharmacotherapy 26:1099-110. 2006..Tigecycline has demonstrated promising results in initial in vitro and clinical studies for SSSIs and complicated intraabdominal infections; however, further clinical experience will clarify its role as a broad-spectrum agent...
- Histone H4 is a major component of the antimicrobial action of human sebocytesDong Youn Lee
Division of Dermatology, University of California San Diego and VA San Diego Healthcare Center, San Diego, California, USA
J Invest Dermatol 129:2489-96. 2009..Taken together, these results indicate that the release of histone H4 by holocrine secretion from the sebaceous gland may play an important role in innate immunity...
- Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patientsM H Kollef
Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
Chest 115:462-74. 1999..To evaluate the relationship between inadequate antimicrobial treatment of infections (both community-acquired and nosocomial infections) and hospital mortality for patients requiring ICU admission...
- Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organsR Bals
Institute for Human Gene Therapy, Department of Medicine and Molecular and Cellular Engineering, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Infect Immun 67:3542-7. 1999..These similarities between murine and human host defense apparatus provide further impetus to evaluate the mouse as a model for studying the human innate host defense system...
- Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistanceX S Pan
Molecular Genetics Group, Department of Cellular and Molecular Sciences, St George s Hospital Medical School, University of London, United Kingdom
J Bacteriol 178:4060-9. 1996..These results suggest that DNA topoisomerase IV is an important target for fluoroquinolones in S. pneumoniae and establish this organism as a useful gram-positive system for resistance studies...
- Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alteratS Brisse
Eijkman Winkler Institute, Utrecht University, 3584 CX, Utrecht, The Netherlands
Antimicrob Agents Chemother 43:2051-5. 1999..Irrespective of the alterations in GyrA and ParC proteins, clinafloxacin exhibited greater activity than all other fluoroquinolones tested against K. pneumoniae and E. aerogenes...
- Effect of drotrecogin alfa (activated) on human endothelial cell permeability and Rho kinase signalingWei Zeng
Lilly Research Laboratories, Indianapolis, IN 46285, USA
Crit Care Med 32:S302-8. 2004....
- Suppression of human prostate cancer cell growth by ciprofloxacin is associated with cell cycle arrest and apoptosisOlivia Aranha
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
Int J Oncol 22:787-94. 2003..Based on our in vitro results, further in-depth in vivo animal or human investigations are warranted...
- Drotrecogin alfa (activated): real-life use and outcomes for the UKKathryn M Rowan
Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, London WC1H 9HR, UK
Crit Care 12:R58. 2008..1% absolute reduction in 28-day mortality. Drotrecogin alfa (activated; DrotAA) was subsequently approved for use in patients with severe sepsis...
- Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sitesIkhlas A El Karim
Oral Science Research Centre, School of Medicine and Dentistry, Queen s University Belfast, BT12 6BP, Northern Ireland, UK
J Neuroimmunol 200:11-6. 2008..aureus. These antimicrobial activities add a further dimension to the immunomodulatory roles for neuropeptides in the inflammatory and immune responses...
- Mutations in the dihydropteroate synthase gene of human-derived Pneumocystis carinii isolates from Italy are infrequent but correlate with prior sulfa prophylaxisLiang Ma
Critical Care Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1662, USA
J Infect Dis 185:1530-2. 2002..The study confirms the association between DHPS mutations and prior sulfa prophylaxis and shows that the prevalence of DHPS mutations in an Italian patient population is lower than that in other populations...
- Anti-microbial properties of histone H2A from skin secretions of rainbow trout, Oncorhynchus mykissJorge M O Fernandes
Gatty Marine Laboratory, School of Biology, University of St Andrews, Fife KY16 8LB, Scotland, U K
Biochem J 368:611-20. 2002..This is the first report to show that, in addition to its classical function in the cell, histone H2A has extremely strong anti-microbial properties and could therefore help contribute to protection against bacterial invasion...
- Genetic characterization of highly fluoroquinolone-resistant clinical Escherichia coli strains from China: role of acrR mutationsH Wang
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, People's Republic of China
Antimicrob Agents Chemother 45:1515-21. 2001..5- to 6-fold. This study shows that mutations in acrR are an additional genetic basis for fluoroquinolone resistance...
- Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coliP Heisig
Pharmazeutische Mikrobiologie, Universitat Bonn, Germany
Antimicrob Agents Chemother 40:879-85. 1996..coli requires at least one parC mutation in addition to the gyrA mutation(s)...
- Mechanisms of adrenomedullin antimicrobial actionRobert P Allaker
Oral Microbiology, Institute of Cell and Molecular Science, Queen Mary, University of London, Newark Street, London E1 2AT, UK
Peptides 27:661-6. 2006..05) more active. It is suggested that postsecretory processing may generate multiple AM congeners that have enhanced antimicrobial activities against a range of potential targets...
- Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shockAnand Kumar
Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, MB, Canada
Crit Care Med 34:1589-96. 2006..To determine the prevalence and impact on mortality of delays in initiation of effective antimicrobial therapy from initial onset of recurrent/persistent hypotension of septic shock...
- 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancerWalter T Hughes
St Jude Children s Research Hospital, Memphis, TN, 38105, USA
Clin Infect Dis 34:730-51. 2002
- Studies on anticancer activities of antimicrobial peptidesDavid W Hoskin
Department of Pathology and Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
Biochim Biophys Acta 1778:357-75. 2008..In this article, we review various studies on different AMPs that exhibit cytotoxic activity against cancer cells. The suitability of cancer cell-targeting AMPs as cancer therapeutics is also discussed...
- Antimicrobial peptides: linking partition, activity and high membrane-bound concentrationsManuel N Melo
Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av Professor Egas Moniz, Lisbon, Portugal
Nat Rev Microbiol 7:245-50. 2009..Strong membrane-binding and micromolar therapeutic concentrations of AMPs indicate that membrane-bound concentrations may be reached that are higher than intuitively expected, triggering disruptive effects on bacteria...
- High-dose, short-course levofloxacin for community-acquired pneumonia: a new treatment paradigmLala M Dunbar
Louisiana State University Medical Center, New Orleans, Louisiana, USA
Clin Infect Dis 37:752-60. 2003..2% and 92.4% in the 750-mg and 500-mg groups, respectively. These data demonstrate that 750 mg of levofloxacin per day for 5 days is at least as effective as 500 mg per day for 10 days for treatment of mild-to-severe CAP...
- Restricting the selection of antibiotic-resistant mutants: a general strategy derived from fluoroquinolone studiesX Zhao
Public Health Research Institute, New York, NY 10016, USA
Clin Infect Dis 33:S147-56. 2001..Application of these principles could drastically restrict the selection of drug-resistant pathogens...
- Drug-resistant Salmonella enterica serotype paratyphi A in IndiaD S Chandel
All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
Emerg Infect Dis 6:420-1. 2000..Paratyphi A abruptly increased in the New Delhi region. In the first 6 months of 1999, 32% of isolates were resistant to both chloramphenicol and cotrimoxazole and another 13% were resistant to more than two antibiotics...
- Treatment of Q fever endocarditis: comparison of 2 regimens containing doxycycline and ofloxacin or hydroxychloroquineD Raoult
Unite des Rickettsies, Faculte de Medecine, Université de la Mediterranée CNRS, Marseille, France
Arch Intern Med 159:167-73. 1999..Q fever endocarditis, caused by Coxiella burnetii, is fatal in 25% to 60% of patients. Currently, treatment with a long-term tetracycline and quinolone regimen for at least 4 years is recommended, although relapses are frequent...
- Fluoroquinolone resistance among Gram-positive cocciDavid C Hooper
Division of Infectious Diseases, Infection Control Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 2696, USA
Lancet Infect Dis 2:530-8. 2002....
- Phylogenetic origin and virulence genotype in relation to resistance to fluoroquinolones and/or extended-spectrum cephalosporins and cephamycins among Escherichia coli isolates from animals and humansJames R Johnson
Medical Service, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
J Infect Dis 188:759-68. 2003..Thus, in E. coli, antibiotic resistance predicts phylogenetic background and virulence potential in a complex, context-dependent fashion...
- The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infectionMilan Chromek
Department of Clinical Microbiology, Microbiology and Tumorbiology Center, Karolinska University Hospital and Karolinska Institutet, SE 171 76 Stockholm, Sweden
Nat Med 12:636-41. 2006..In addition, clinical E. coli strains that were more resistant to LL-37 caused more severe urinary tract infections than did susceptible strains. Thus, cathelicidin seems to be a key factor in mucosal immunity of the urinary tract...
- Expression of lux genes in a clinical isolate of Streptococcus pneumoniae: using bioluminescence to monitor gemifloxacin activityS J Beard
Faculty of Applied Sciences, University of the West of England, United Kingdom
Antimicrob Agents Chemother 46:538-42. 2002..Light output was correlated with measurements of optical density and viable counts during exponential growth and provided a sensitive, real-time measure of the pharmacodynamics of the fluoroquinolone gemifloxacin...
- Initiating co-trimoxazole prophylaxis in HIV-infected patients in Africa: an evaluation of the provisional WHO/UNAIDS recommendationsM Badri
Infectious Diseases Clinical Research Unit, Lung Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
AIDS 15:1143-8. 2001..Further studies are needed to assess the optimal time of commencement of prophylaxis, as widespread co-trimoxazole use will lead to increasing antimicrobial resistance to other major pathogens in Africa...
- In vitro and in vivo activities of levofloxacin against biofilm-producing Pseudomonas aeruginosaH Ishida
New Product Research Laboratories I, Daiichi Pharmaceutical Co, Ltd, Tokyo, Japan
Antimicrob Agents Chemother 42:1641-5. 1998..These findings suggest the significant role of levofloxacin in therapy of biofilm bacterium-associated infectious diseases...
- Origin of plasmid-mediated quinolone resistance determinant QnrALaurent Poirel
Service de Bacteriologie Virologie, Hopital de Bicetre, 78, rue du General Leclerc, 94275 Le Kremlin Bicetre, France
Antimicrob Agents Chemother 49:3523-5. 2005..Shewanella algae, an environmental species from marine and fresh water, was identified as its reservoir. This is a one of the very few examples of progenitor identification of an acquired antibiotic resistance gene...
- Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virusVanesa C Albiol Matanic
Laboratorio de Virologia, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon II, Piso 4, C1428BGA Buenos Aires, Argentina
Int J Antimicrob Agents 23:382-9. 2004....
- Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cellsC Herold
Department of Medicine I, University of Erlangen Nuernberg, Krankenhausstr 12, D 91054 Erlangen, Germany
Br J Cancer 86:443-8. 2002..Therefore, qualification of ciprofloxacin as adjunctive agent for colorectal cancer should be evaluated...
- Effect of co-trimoxazole prophylaxis on morbidity, mortality, CD4-cell count, and viral load in HIV infection in rural UgandaJonathan Mermin
CDC Uganda, Global AIDS Program, National Center for HIV, STD and TB Prevention, National Center for Infectious Diseases Centers for Disease Control and Prevention, Atlanta, GA, USA
Lancet 364:1428-34. 2004..We assessed the effect of such prophylaxis on morbidity, mortality, CD4-cell count, and viral load among people with HIV infection living in rural Uganda, an area with high rates of bacterial resistance to co-trimoxazole...
- Determining the feasibility of utilizing the microbicide applicator compliance assay for use in clinical trialsAndrea R Wallace
Population Council, New York, NY 10021, USA
Contraception 76:53-6. 2007..In addition, trypan blue is carcinogenic and thus potentially hazardous to technicians spraying daily...
- Properties and applications of antimicrobial peptides in biodefense against biological warfare threat agentsRaymond Murray Dawson
DSTO Defense Science and Technology Organisation, Melbourne, Australia
Crit Rev Microbiol 34:89-107. 2008..Synthesis of these peptides in multivalent form leads to a synergistic increase in antibacterial activity. Strategies to enhance the potency, stability, and selectivity of AMPs are discussed...
- The cDNA of the neutrophil antibiotic Bac5 predicts a pro-sequence homologous to a cysteine proteinase inhibitor that is common to other neutrophil antibioticsM Zanetti
Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Universita di Trieste, Italy
J Biol Chem 268:522-6. 1993..The COOH-terminal sequences of these antibiotics are completely unrelated. The proregion also exhibits remarkable similarity to pig cathelin, an inhibitor of cathepsin L, indicating a common evolutionary origin...
- Identification and functional characterization of three chicken cathelicidins with potent antimicrobial activityYanjing Xiao
Department of Animal Science, Oklahoma State University, Stillwater, Oklahoma 74078, USA
J Biol Chem 281:2858-67. 2006..Their broad spectrum and salt-insensitive antibacterial activities, coupled with their potent LPS-neutralizing activity, make fowlicidins excellent candidates for novel antimicrobial and anti-sepsis agents...
- What is the real role of antimicrobial polypeptides that can mediate several other inflammatory responses?Peter Elsbach
Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
J Clin Invest 111:1643-5. 2003..Their role is now widening following evidence that one such multifunctional peptide, LL-37, induces angiogenesis, a process essential for host defense, wound healing, and tissue repair...
- Structural features and biological activities of the cathelicidin-derived antimicrobial peptidesR Gennaro
Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Universita di Trieste, Via Giorgieri, 1, 34127 Trieste, Italy
Biopolymers 55:31-49. 2000....
- Primate defensinsRobert I Lehrer
Department of Medicine and Molecular Biology Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
Nat Rev Microbiol 2:727-38. 2004..Here, their discovery and recent advances in understanding their properties and functions are described...
- Papillomavirus microbicidal activities of high-molecular-weight cellulose sulfate, dextran sulfate, and polystyrene sulfonateN D Christensen
The Jake Gittlen Cancer Research Institute and Department of Pathology, The Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
Antimicrob Agents Chemother 45:3427-32. 2001..These data indicate that the polysulfated and polysulfonated compounds may be useful nontoxic microbicidal compounds that are active against a variety of sexually transmitted disease agents including papillomaviruses...
- The first antimicrobial peptide from sea amphibianYi Lu
College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China
Mol Immunol 45:678-81. 2008..The current results reported a new family of amphibian antimicrobial peptide and the first antimicrobial peptide from sea amphibian...
- Efficacy of Carraguard-based microbicides in vivo despite variable in vitro activityStuart G Turville
Center for Biomedical Research, HIV and AIDS Program, Population Council, New York, New York, United States of America
PLoS ONE 3:e3162. 2008..This work also underscores the potential of Carraguard-based formulations for the delivery of anti-viral drugs to prevent vaginal HIV infection...
- Identification, cloning, characterization and recombinant expression of an anti-lipopolysaccharide factor from the hemocytes of Indian mud crab, Scylla serrataRoshan Dinesh Yedery
Division of Molecular Immunology, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Jehangir Merwanji Street, Parel, Mumbai 400 012, India
Fish Shellfish Immunol 27:275-84. 2009..These studies strongly suggest that SsALF is one among the important antimicrobial factors produced in the crab during a microbial invasion...
- Spread of ampicillin/vancomycin-resistant Enterococcus faecium of the epidemic-virulent clonal complex-17 carrying the genes esp and hyl in German hospitalsI Klare
Robert Koch Institute, Wernigerode Branch, Burgstr 37, 38855, Wernigerode, Germany
Eur J Clin Microbiol Infect Dis 24:815-25. 2005..In conclusion, it is very important to monitor the occurrence of epidemic-virulent clonal complex-17 strains of E. faecium to prevent their spread in hospitals, especially if they are resistant to glycopeptides and linezolid...
- Antimicrobial peptides of vertebratesT Ganz
Department of Medicine, University of California School of Medicine, Los Angeles 90095 1690, USA
Curr Opin Immunol 10:41-4. 1998..Other highlights included new insights into the relative selectivity of antimicrobial peptides for microbial membranes, their primary site of action...
- Hyastatin, a glycine-rich multi-domain antimicrobial peptide isolated from the spider crab (Hyas araneus) hemocytesSigmund V Sperstad
Department of Marine Biotechnology, University of Tromsø, Norway
Mol Immunol 46:2604-12. 2009..Both hyastatin and the N-terminal region had the ability to bind chitin. Conclusively, this indicates the importance of the Cys-containing region for the antimicrobial activity, and a possible multifunctional character of hyastatin...
- Relish, a central factor in the control of humoral but not cellular immunity in DrosophilaM Hedengren
Umeå Center for Molecular Pathogenesis, Umea University, Sweden
Mol Cell 4:827-37. 1999..Our results illustrate the importance of the humoral response in Drosophila immunity and demonstrate that Relish plays a key role in this response...
- Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolatesJ Engberg
Department of Gastrointestinal Infections, Division of Diagnostics, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
Emerg Infect Dis 7:24-34. 2001....
- Prevention of intravascular catheter-related infectionsL A Mermel
Division of Infectious Diseases, Rhode Island Hospital and Brown University School of Medicine, Providence 02903, USA
Ann Intern Med 132:391-402. 2000..To review the literature on prevention of intravascular catheter-related infections...
- Carbohydrate-based Antiinfective AgentsChi Huey Wong; Fiscal Year: 2013..A strategy for a carbohydrate-modified HA protein vaccine is presented, with attention directed toward maximizing cross-reactive immunity. ..
- Pathogen-Specific Regulation of Protein AssemblyALLEN BERNARD REITZ; Fiscal Year: 2010..We first seek to apply our strategy to the discovery of agents to treat Yersinia enterocolitica, an NIAID Category B priority pathogen. ..
- Cell Surface Protein Anchoring and Function in Gram-Positive BacteriaROBERT THOMPSON CLUBB; Fiscal Year: 2013..Collectively, this research will increase our understanding of the molecular basis of S. aureus pathogenesis and it could lead to new therapeutics to treat bacterial infections. ..
- Discovering New Anti-Infective Agents from LysobacterLiangcheng Du; Fiscal Year: 2013..The deciphering of the biosynthetic mechanism for these structurally distinct and biologically active products will allow for designing rational strategiesin the development of the products as new anti-infectives. ..
- Targeting DXP Synthase in Non-mammalian Isoprenoid BiosynthesisFRANCINE M MORRIS; Fiscal Year: 2012..The long term goal is to develop novel, potent and broad-based anti-microbial agents that also exhibit limited toxicity to the human host. ..
- Viral and Microbial RNA Modifying EnzymesSTEWART H SHUMAN; Fiscal Year: 2013....
- Targeting a Unique Enzyme Mechanism in Non-Mammalian Isoprenoid BiosynthesisJessica M Smith; Fiscal Year: 2013..The rationale for the proposed studies is that developing strategies for selective inhibition of this enzyme will provide new tools for investigating this essential pathway in pathogens and will lead to new anti-infective agents. ..
- Oligosaccharides to Prevent Infectious DiarrheaJOHN MICHAEL MCCOY; Fiscal Year: 2012..abstract_text> ..
- ADHESIN-BASED NANOTHERAPEUTICS IN URINARY TRACT INFECTIONDAVID ALAN HUNSTAD; Fiscal Year: 2013..We will evaluate the ability of these nanoparticles to prevent and treat UTI. ..
- AGE-RELATED GASTRIC CHANGES AND DRUG ABSORPTIONAryeh Hurwitz; Fiscal Year: 1993..Extension of such studies to other classes of drugs will make possible rational prediction of altered drug bioavailability in the elderly...
- Hemoglobin Capture and Heme Acquisition by the Pathogen Staphylococcus AureusMEGAN MARIE SJODT; Fiscal Year: 2013..The results of this research could therefore facilitate the development of anti-infective agents that work by inhibiting heme acquisition. ..
- Quality Control of Protein TranslationA Wali Karzai; Fiscal Year: 2012..Ultimately, these insights will have implications for a better understanding of a variety of cellular processes, including control of gene expression, synthesis and degradation of proteins, and the targeted decay defective mRNAs. ..
- Prenyl Synthase Inhibitors: Novel Anti-Infective AgentsEric Oldfield; Fiscal Year: 2013..Focus will be on developing inhibitors for three unique targets in malaria parasites, and on the use of novel drugs against sleeping sickness. ..
- Design and analysis of random copolymers with antimicrobial activityJames C Weisshaar; Fiscal Year: 2013..Random copolymers may find applications in the context of antifungal activity, antiplasmodial activity, and lung-surfactant activity as well. ..
- The multiple states of IpaB Shigella type III secretionWilliam D Picking; Fiscal Year: 2013..This study is anticipated to reveal mechanistic aspects of T3SS may be targeted by anti-infective agents. ..
- ANTIFUNGAL RESPONSE--MDR INDUCTIONThomas Edlind; Fiscal Year: 2002..Candida homologues of these factors will be identified by PCR or expression in S. cerevisiae. Their role in MDR induction will be examined by gene disruption. ..
- Development of RSK Inhibitors as Novel Therapeutics for Yersinia pestisJeffrey Smith; Fiscal Year: 2010..The proposed research is designed to develop our novel anti-infective agent toward clinical application as an anti-Yersinia pestis agent. ..
- ESAT-6 Secretion in Staphylococcus AureusDominique M Missiakas; Fiscal Year: 2013..Moreover, staphylococcal esxB mutants are interrogated for the genetic requirements of generating protective immunity against S. aureus disease. ..
- Chemical Synthesis of Bioactive Flavonoid and Xanthone-Derived Natural ProductsJohn A Porco; Fiscal Year: 2013....
- Synthesis of Anti-Infective AgentsK C Nicolaou; Fiscal Year: 2013..Therefore, the work is expected to have a broad and positive impact on chemistry, biology, and medicine. ..
- Membrane Permeable Diphosphate Analogs Targeting Pathogen Isoprenoid BiosynthesisCAREN L MEYERS; Fiscal Year: 2013..These studies will provide a foundation for the transformation of highly polar, potent inhibitors of isoprenoid biosynthesis into useful therapeutic agents for the treatment of infectious diseases. ..
- Tight Adherence Genes of a Periodontal PathogenDavid H Figurski; Fiscal Year: 2012..These chemicals may be developed into new antibiotic drugs, supporting therapy for multiple types of infection. ..
- Novel Inhibitors to DHPS to Probe Catalytic Mechanism &Therapeutic Potential - rStephen W White; Fiscal Year: 2013..aureus and P. jirovecii that have emerged as particularly problematical infectious disease agents in the U.S. in recent years. ..
- Mechanistic analysis of flavonoids on bacterial virulenceHoward C Hang; Fiscal Year: 2013..Given the emergence of new and antibiotic-resistant bacterial pathogens, our studies should afford new anti-infective agents combat bacterial infections in humans. ..
- Engineered Probiotic Yeast to Prevent Infectious DiarrheaJohn McCoy; Fiscal Year: 2009..The surface ??(1,2) fucosylated probiotic K.lactis that is the subject of this application will target both Norwalk-like viruses and C.jejuni, as well as other fucose-binding enteropathogens. ..
- Safety Evaluation of Anti-Infective AgentsJon Mirsalis; Fiscal Year: 2013..The scope of this effort is to evaluate the toxicity and pharmacokinetics of potential chemical and biological therapies for AIDS and other infectious diseases in various laboratory animal species. ..
- Safety Evaluation of Anti-Infective AgentsJon Mirsalis; Fiscal Year: 2010..The scope of this effort is to evaluate the toxicity and pharmacokinetics of potential chemical and biological therapies for AIDS and other infectious diseases in various laboratory animal species. ..
- Safety Evaluation of Anti-Infective AgentsJon Mirsalis; Fiscal Year: 2011..The scope of this effort is to evaluate the toxicity and pharmacokinetics of potential chemical and biological therapies for AIDS and other infectious diseases in various laboratory animal species. ..
- Safety Evaluation of Anti-Infective AgentsJon Mirsalis; Fiscal Year: 2012
- CONTAINMENT FACILITIES FOR ANIMAL HOUSING AND RESEARCHMICHAEL DINGERSON; Fiscal Year: 1992..In this interim period (1992-1995), it is critical that this institution maintain and extend its commitment to the provision of suitable facilities in support of our animal research programs in biomedical science...
- Targeting Non-mammalian Isoprenoid BiosynthesisCAREN L MEYERS; Fiscal Year: 2013..Anti-infective agents developed to target these enzymes have the potential to broadly impact the treatment of deadly infectious diseases. ..
- HTS on Riboflavin and Terpene Biosynthetic Enzymes(RMI)Adelbert Bacher; Fiscal Year: 2005..Follow-up work in cooperation with Prof. Cushman will be directed at the development of candidate compounds into actual anti-infective drugs by medicinal chemistry methods. ..
- Dev & Testing of New Medications for Treatment of Emerging Infectious DiseasesMitchell Avery; Fiscal Year: 2006..This allows LADDS infrastructure to inch forward now to the last stages of drug development that are achievable with academic economics. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- GENERATION OF KETOLIDES BY COMBINATORIAL BIOSYNTHESISYongquan Xue; Fiscal Year: 1999..abstract_text> ..
- DETERMINANTS IN PLATELET MICROBICIDAL PROTEINSMichael Yeaman; Fiscal Year: 2004..Thus, these studies will significantly advance our understanding of antimicrobial host defense, and may yield new modes for its amplification. ..
- Sortase A anchoring mechanismDEBORAH LEON ROSSELL; Fiscal Year: 2007..Work leading to the creation of anti-infective agents against pathogenic bacteria should be prioritized especially in an era where bacteria have developed a resistance to many commonly used antibiotics. [unreadable] [unreadable]..
- APPROACHES TO CHARACTERIZATION OF ANTIINFECTIVE AGENTSMark Hamann; Fiscal Year: 2002..SAR studies will be conducted utilizing chemical and microbial transformations of biologically active secondary metabolites combined with molecular modeling studies. ..
- Improving Glycosyltransferase by RACHITT Gene ShufflingYongquan Xue; Fiscal Year: 2001..This will be a key step in combinatorial biosynthesis of ketolide antibiotics that have a potential to combat multi-drug resistant bacterial pathogens. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
- Anti-infectives with Multi-domain Ribosomal BindingLeonard Katz; Fiscal Year: 2002..PROPOSED COMMERCIAL APPLICATION: Clinical development candidates could be commericialized as anti-infective agents only after approval by the appropriate regulatory authorities...
- SYNTHESIS OF ANTIINFECTIVE AGENTSSamuel Danishefsky; Fiscal Year: 2002..The scope of this inquiry includes lipid conjugates to replace (or augment) KLH, clustered presentations to mimic antigen as presentations in mucins, and antigen analogs in the hope of triggering more aggressive immune responses. ..
- RNA-Targeted Antimicobial AgentsJING SHEN DENG; Fiscal Year: 2003..Successful completion of this Phase II research will lead to the identification of a new class of anti-infective agents. ..
- RESYNTHESIS OF THERAPEUTIC AGENTS FOR TREAT. OF INFECTJAROSLAV NOVOTNY; Fiscal Year: 2000....
- Structure-Based Design of Bacterial GTPase InhibitorsMark Shenderovich; Fiscal Year: 2004..abstract_text> ..
- Novel Single, Dual and Multitargeted Inhibitors of RTKsAleem Gangjee; Fiscal Year: 2007..abstract_text> ..
- STRUCTURE BASED ANALOGS AS ANTIOPPORTUNISTIC AGENTSAleem Gangjee; Fiscal Year: 2001..The analogues synthesized will also be submitted for screening against tuberculosis (NIAID) parasitic diseases (WHO) and tumor cells in culture (NCI). ..
- Third Generation Antiopportunistic AgentsAleem Gangjee; Fiscal Year: 2003..Screening against tuberculosis (NIAID) and tumor cells in culture (NCI) is also proposed. ..
- Antitumor Antimitotics That Reverse Tumor ResistanceAleem Gangjee; Fiscal Year: 2010..The study will also further define the mechanism of action of the novel series and could afford agents for clinical use. ..
- NOVEL NONINDUCIBLE THYMIDYLATE SYNTHASE INHIBITORSAleem Gangjee; Fiscal Year: 2004....
- Neuroprotective Role of Fetuin in Cerebral IschemiaHaichao Wang; Fiscal Year: 2008..Answers to these questions will improve our understanding of the pathophysiology of ischemic neural injury, and identify novel therapeutic agents for the treatment of stroke and related disorders. ..
- Novel, P. jirovecii Specific Antipneumocystis AgentsAleem Gangjee; Fiscal Year: 2009..These agents could be used alone or in combination to treat PCP thus providing novel agents against a new target. ..
- Single Agents with Designed Combination Chemotherapy PotentialAleem Gangjee; Fiscal Year: 2010..abstract_text> ..
- A Contextual Model of Microbicide AcceptabilityKathleen Morrow; Fiscal Year: 2005..abstract_text> ..
- Linking Biophysical Functions of Microbicides to User Perception & AcceptabilityKathleen Morrow; Fiscal Year: 2007..In sum, this work will contribute methodology leading to rational design of microbicide formulations that co-optimize vaginal distribution and retention with user acceptability. ..
- Alpha Folate Receptor Mediated GARFTase Inhibitors as Selective Antitumor AgentsAleem Gangjee; Fiscal Year: 2010....
- Resistant E.coli in Humans and PoultryJames Johnson; Fiscal Year: 2005..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
- Mechanism of Action of Novel Dual Actiing PyrimidinedionesRobert Buckheit; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Improved Macaque Safety Model for Topical Microbicides: Post-coital AssessmentsDorothy Patton; Fiscal Year: 2008..In addition, we will collect parallel assessments, when mating has occurred with a placebo gel (HEC universal placebo) in place. These studies will provide urgently needed data regarding topical microbicide use with coital activity. ..
- Innate Immunity and exacerbations of COPDSanjay Sethi; Fiscal Year: 2009..The overall goal of this research is to identify specific aspects of the innate defense of the lung that determine the frequency of exacerbations in COPD that will serve as potential therapeutic targets to reduce exacerbations. ..
- Therapeutic Development of Antimicrobial BiomimeticsRichard Scott; Fiscal Year: 2008..The projected use for the developed product is as an iv injectable antibiotic to treat hospital-acquired infections. [unreadable] [unreadable] [unreadable]..
- Enhancing HIV Medication Adherence in IndiaDEBORAH LYNNE JONES; Fiscal Year: 2010....
- Pediatric HIV-encephalopathy in DRC: effect of ART & role of compartmentalizationAnnelies Van Rie; Fiscal Year: 2010....
- Mechanisms of HIV Transport Across the BBBWilliam Banks; Fiscal Year: 2004....
- Oral Immunology/Microbiology Research Group Annual MtgDaniel Fine; Fiscal Year: 2003..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
- Ethanol, Tat and the Blood-brain barrierKwang Kim; Fiscal Year: 2004..e., nitric oxide and signaling pathways. The information derived from this proposal should enhance our understanding of the role of ethanol in HIV-1 neuropthogenesis. ..