anti infective agents

Summary

Summary: Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.

Top Publications

  1. ncbi Antibacterial resistance worldwide: causes, challenges and responses
    Stuart B Levy
    Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Nat Med 10:S122-9. 2004
  2. ncbi Typhoid fever
    Christopher M Parry
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    N Engl J Med 347:1770-82. 2002
  3. ncbi Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection
    Joaquim Ruiz
    Department of Microbiology, Institut Clinic Infeccions i Immunologia, Hospital Clinic, C Villarroel 170, 08036 Barcelona, Spain
    J Antimicrob Chemother 51:1109-17. 2003
  4. ncbi Immunomodulatory effects of quinolones
    Axel Dalhoff
    Institute for Medical Microbiology and Virology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Germany
    Lancet Infect Dis 3:359-71. 2003
  5. pmc Characterization of Streptomyces spp. isolated from the sea surface microlayer in the Trondheim Fjord, Norway
    Sigrid Hakvåg
    Department of Biotechnology, Norwegian University of Science and Technology, N 7491 Trondheim, Norway
    Mar Drugs 6:620-35. 2008
  6. ncbi Antimicrobial peptides from ranid frogs: taxonomic and phylogenetic markers and a potential source of new therapeutic agents
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666 Al Ain, United Arab Emirates
    Biochim Biophys Acta 1696:1-14. 2004
  7. ncbi Mechanism of adenovirus neutralization by Human alpha-defensins
    Jason G Smith
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Host Microbe 3:11-9. 2008
  8. ncbi Acceptability of Carraguard vaginal gel use among Thai couples
    Sara J Whitehead
    National Center for HIV, Viral Hepatitis, STDs, and Tuberculosis Prevention proposed, Centers for Disease Control and Prevention, Atlanta, USA
    AIDS 20:2141-8. 2006
  9. pmc Antimicrobial activity of omwaprin, a new member of the waprin family of snake venom proteins
    Dileep G Nair
    Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543
    Biochem J 402:93-104. 2007
  10. ncbi Antimicrobial activity of the leaves and seeds of Bixa orellana
    T C Fleischer
    Department of Pharmacognosy, Faculty of Pharmacy, K N U S T, Kumasi, Ghana
    Fitoterapia 74:136-8. 2003

Research Grants

Detail Information

Publications272 found, 100 shown here

  1. ncbi Antibacterial resistance worldwide: causes, challenges and responses
    Stuart B Levy
    Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Nat Med 10:S122-9. 2004
    ..Drug resistance presents an ever-increasing global public health threat that involves all major microbial pathogens and antimicrobial drugs...
  2. ncbi Typhoid fever
    Christopher M Parry
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    N Engl J Med 347:1770-82. 2002
  3. ncbi Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection
    Joaquim Ruiz
    Department of Microbiology, Institut Clinic Infeccions i Immunologia, Hospital Clinic, C Villarroel 170, 08036 Barcelona, Spain
    J Antimicrob Chemother 51:1109-17. 2003
    ..Recently, mobile elements have also been described, carrying the qnr gene, which confers resistance to quinolones...
  4. ncbi Immunomodulatory effects of quinolones
    Axel Dalhoff
    Institute for Medical Microbiology and Virology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Germany
    Lancet Infect Dis 3:359-71. 2003
    ....
  5. pmc Characterization of Streptomyces spp. isolated from the sea surface microlayer in the Trondheim Fjord, Norway
    Sigrid Hakvåg
    Department of Biotechnology, Norwegian University of Science and Technology, N 7491 Trondheim, Norway
    Mar Drugs 6:620-35. 2008
    ..The results obtained in this study suggest that streptomycetes from the neuston population may be an interesting source for discovery of new antimicrobial agents...
  6. ncbi Antimicrobial peptides from ranid frogs: taxonomic and phylogenetic markers and a potential source of new therapeutic agents
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666 Al Ain, United Arab Emirates
    Biochim Biophys Acta 1696:1-14. 2004
    ....
  7. ncbi Mechanism of adenovirus neutralization by Human alpha-defensins
    Jason G Smith
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Host Microbe 3:11-9. 2008
    ..Thus, defensins possess remarkably distinct modes of activity against bacteria and viruses, and their function may provide insights for the development of new antiviral strategies...
  8. ncbi Acceptability of Carraguard vaginal gel use among Thai couples
    Sara J Whitehead
    National Center for HIV, Viral Hepatitis, STDs, and Tuberculosis Prevention proposed, Centers for Disease Control and Prevention, Atlanta, USA
    AIDS 20:2141-8. 2006
    ..To evaluate the acceptability of candidate microbicide Carraguard among couples participating in a safety trial...
  9. pmc Antimicrobial activity of omwaprin, a new member of the waprin family of snake venom proteins
    Dileep G Nair
    Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543
    Biochem J 402:93-104. 2007
    ....
  10. ncbi Antimicrobial activity of the leaves and seeds of Bixa orellana
    T C Fleischer
    Department of Pharmacognosy, Faculty of Pharmacy, K N U S T, Kumasi, Ghana
    Fitoterapia 74:136-8. 2003
    ..The ethanolic extracts of the leaves and seeds of Bixa orellana showed a broad spectrum of antimicrobial activity. The activity of the leaf extract was more pronounced...
  11. pmc Anti-inflammatory effects of moxifloxacin on activated human monocytic cells: inhibition of NF-kappaB and mitogen-activated protein kinase activation and of synthesis of proinflammatory cytokines
    Taly Weiss
    Department of Cell Biology and Histology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Antimicrob Agents Chemother 48:1974-82. 2004
    ..Its anti-inflammatory properties should be further assessed in clinical settings...
  12. ncbi Fitness cost of fluoroquinolone resistance in Salmonella enterica serovar Typhimurium
    Etienne Giraud
    Unité Bio Agresseurs, santé, Environnement, Institut National de la Recherche Agronomique, Centre de Recherche de Tours, 37380 Nouzilly, France
    J Med Microbiol 52:697-703. 2003
    ....
  13. ncbi Origin of low mammalian cell toxicity in a class of highly active antimicrobial amphipathic helical peptides
    Ayman Hawrani
    Department of Cellular and Molecular Medicine, Bristol University, Bristol BS8 1TD, United Kingdom
    J Biol Chem 283:18636-45. 2008
    ..We highlight a significant role for tryptophan in promoting binding of amphipathic helical peptides to neutral bilayers, augmenting the arsenal of strategies to reduce mammalian toxicity in antimicrobial peptides...
  14. pmc Antimicrobial characterization of human beta-defensin 3 derivatives
    David M Hoover
    Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Antimicrob Agents Chemother 47:2804-9. 2003
    ..aureus and C. albicans. Further, N-terminal deletion mutants of native hBD3 showed diminished activities against S. aureus. Thus, the antimicrobial properties of hBD3 derivatives are determined by both charge and structure...
  15. pmc Analysis of antimicrobial susceptibility and virulence factors in Helicobacter pylori clinical isolates
    Anita Paula Ortiz Godoy
    Clinical Pharmacology and Gastroenterology Unit, Sao Francisco University Medical School, Braganca Paulista, SP, Brazil
    BMC Gastroenterol 3:20. 2003
    ..In addition, the vacA, iceA, cagA and cagE genotypes of strains isolated from Brazilian patients were determined and associated with clinical data in an effort to correlate these four virulence markers and antibiotic resistance...
  16. pmc Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections
    Patricia Komp Lindgren
    Department of Cell and Molecular Biology, Microbiology Programme, Biomedical Center, Uppsala University, S 751 24 Uppsala, Sweden
    Antimicrob Agents Chemother 47:3222-32. 2003
    ..This correlation suggests that an increased general mutation rate may play a significant role in the development of high-level resistance to fluoroquinolones by increasing the rate of accumulation of rare new mutations...
  17. pmc Human alpha-defensins inhibit BK virus infection by aggregating virions and blocking binding to host cells
    Aisling S Dugan
    Department of Molecular Biology, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 283:31125-32. 2008
    ..We also show a novel mechanism whereby HD5 binds to BKV leading to aggregation of virion particles preventing normal virus binding to the cell surface and uptake into cells...
  18. ncbi cDNA sequences of three sheep myeloid cathelicidins
    L Bagella
    Laboratorio Nazionale Consorzio Interuniversitario Biotechnologie, CIB, Trieste, Italy
    FEBS Lett 376:225-8. 1995
    ..5, which appears to be a new member of the Pro- and Arg-rich group of mammalian antimicrobial peptides...
  19. ncbi Functions of antimicrobial peptides in host defense and immunity
    Christoph Beisswenger
    Hospital of the University of Marburg, Department of Internal Medicine, Division of Pulmonary Medicine, Philipps University Marburg, Germany
    Curr Protein Pept Sci 6:255-64. 2005
    ..This review summarizes the current knowledge about the basic and applied biology of antimicrobial peptides and discusses features of AMPs in host defense and inflammation...
  20. pmc Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor
    M Zasloff
    Proc Natl Acad Sci U S A 84:5449-53. 1987
    ..The sequence of a partial cDNA of the precursor reveals that both peptides derive from a common larger protein. These peptides appear to represent a previously unrecognized class of vertebrate antimicrobial activities...
  21. ncbi Shifting trends in bacterial keratitis in south Florida and emerging resistance to fluoroquinolones
    G Alexandrakis
    Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA
    Ophthalmology 107:1497-502. 2000
    ..To study the distribution, current trends, and patterns of resistance to antimicrobial agents of bacterial keratitis isolates in South Florida...
  22. ncbi Risks factors and prevention of Q fever endocarditis
    F Fenollar
    , Centre Nationale de Recherche Scientifique, , , 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Clin Infect Dis 33:312-6. 2001
    ..A proper treatment for such patients and a scheduled follow-up should reduce the risk of developing endocarditis...
  23. ncbi Lactoferrin: an important host defence against microbial and viral attack
    P Valenti
    Dipartimento di Medicina Sperimentale, II Universita di Napoli, Italy
    Cell Mol Life Sci 62:2576-87. 2005
    ....
  24. ncbi Multifunctional host defense peptides: intracellular-targeting antimicrobial peptides
    Pierre Nicolas
    BIOgenèse des SIgnaux PEptidiques, ER3 UPMC, Universite Pierre et Marie Curie, Paris, France
    FEBS J 276:6483-96. 2009
    ..e. Trp and Pro, His, or Arg. Differences in membrane lipid composition, as well as differential lipid recruitment by peptides, may provide a basis for microbial cell killing on one hand, and mammalian cell passage on the other...
  25. ncbi Pharmacokinetics and elimination of moxifloxacin after oral and intravenous administration in man
    H Stass
    Pharma Research Center, Institute of Clinical Pharmacology, Bayer AG, Wuppertal, Germany
    J Antimicrob Chemother 43:83-90. 1999
    ..Plasma concentrations of the metabolites were much lower than those of the parent compound. Moxifloxacin was well tolerated with few adverse events and no clinically relevant changes in laboratory values...
  26. ncbi Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    C H Park
    Departments of Medicine and Pathology, UCLA School of Medicine, Los Angeles, California 90059, USA
    J Biol Chem 276:7806-10. 2001
    ..Hepcidin may be a vertebrate counterpart of cysteine-rich antimicrobial peptides produced in the fat body of insects...
  27. pmc Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China
    Minggui Wang
    Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China
    Antimicrob Agents Chemother 47:2242-8. 2003
    ..coli from Shanghai and may contribute to the rapid increase in bacterial resistance to quinolones in China...
  28. ncbi Carrageenan/MIV-150 (PC-815), a combination microbicide
    Jose A Fernández-Romero
    Population Council, New York, NY, USA
    Sex Transm Dis 34:9-14. 2007
    ....
  29. ncbi Aurelin, a novel antimicrobial peptide from jellyfish Aurelia aurita with structural features of defensins and channel-blocking toxins
    Tatiana V Ovchinnikova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho Maklaya Str 16 10, 117997 Moscow, Russia
    Biochem Biophys Res Commun 348:514-23. 2006
    ..Aurelin has no structural homology with any previously identified antimicrobial peptides but reveals partial similarity both with defensins and K+ channel-blocking toxins of sea anemones and belongs to ShKT domain family...
  30. ncbi Antibiotics for upper respiratory tract infections: an overview of Cochrane reviews
    B Arroll
    Department of General Practice and Primary Health Care, University of Auckland, Auckland New Zealand
    Respir Med 99:255-61. 2005
    ..The aim of this paper is to review the four Cochrane reviews of antibiotics for upper respiratory tract infections...
  31. pmc FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis
    B Agerberth
    Department of Microbiology, Stockholm University, Sweden
    Proc Natl Acad Sci U S A 92:195-9. 1995
    ..RNA blot analyses disclosed that the gene for FALL-39 is expressed mainly in human bone marrow and testis...
  32. pmc Fluoroquinolones and the risk for methicillin-resistant Staphylococcus aureus in hospitalized patients
    Stephen G Weber
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Emerg Infect Dis 9:1415-22. 2003
    ..4; p <0.0001; ciprofloxacin OR 2.5; p = 0.005) but not MSSA. Exposure to levofloxacin or ciprofloxacin is a significant risk factor for the isolation of MRSA, but not MSSA...
  33. pmc gyrA mutations associated with fluoroquinolone resistance in eight species of Enterobacteriaceae
    L M Weigel
    Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 42:2661-7. 1998
    ..The type and position of amino acid alterations also differed among these six genera. High-level FQ-R frequently was associated with single gyrA mutations in all species of Enterobacteriaceae in this study except E. coli...
  34. ncbi Control of cell selectivity of antimicrobial peptides
    Katsumi Matsuzaki
    Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Biochim Biophys Acta 1788:1687-92. 2009
    ..Pros and cons of these approaches are discussed...
  35. pmc Association of Atopobium vaginae, a recently described metronidazole resistant anaerobe, with bacterial vaginosis
    Michael J Ferris
    Dept of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    BMC Infect Dis 4:5. 2004
    ..The bacterium Atopobium vaginae has been recognized only recently. It is not readily identified by commercial diagnostic kits. Its clinical significance is unknown but it has recently been isolated from a tuboovarian abcess...
  36. ncbi Guidelines for the selection of anti-infective agents for complicated intra-abdominal infections
    Joseph S Solomkin
    Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0558, USA
    Clin Infect Dis 37:997-1005. 2003
  37. pmc Human alpha-defensins block papillomavirus infection
    Christopher B Buck
    Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute NIH, Bethesda, MD 20892 4263, USA
    Proc Natl Acad Sci U S A 103:1516-21. 2006
    ....
  38. ncbi A randomized, placebo-controlled trial to assess the safety and acceptability of use of carraguard vaginal gel by heterosexual couples in Thailand
    Peter H Kilmarx
    National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Sex Transm Dis 35:226-32. 2008
    ..To determine the safety and acceptability of use of Carraguard, a carrageenan-derived candidate microbicide gel, during sexual intercourse in women and men...
  39. ncbi Isolation and analysis of bacteria with antimicrobial activities from the marine sponge Haliclona simulans collected from Irish waters
    Jonathan Kennedy
    Environmental Research Institute, University College Cork, Cork, Ireland
    Mar Biotechnol (NY) 11:384-96. 2009
    ..This study demonstrates that the culturable fraction of bacteria from the sponge H. simulans is diverse and appears to possess much potential as a source for the discovery of new medically relevant biological active agents...
  40. ncbi A major transition in malaria treatment: the adoption and deployment of artemisinin-based combination therapies
    Andrea Bosman
    World Health Organization, Avenue Appia 20, Geneva, Switzerland
    Am J Trop Med Hyg 77:193-7. 2007
    ..Artemisinins as monotherapies are widely available in the private sector of 47 endemic countries, and their consumption will, if unabated, promote resistance to artemisinins and compromise the effectiveness of ACTs...
  41. ncbi Molecular mechanisms of membrane perturbation by antimicrobial peptides and the use of biophysical studies in the design of novel peptide antibiotics
    K Lohner
    Institute of Biophysics and X ray Structure Research, Austrian Academy of Sciences, A 8042 Graz, Austria
    Comb Chem High Throughput Screen 8:241-56. 2005
    ..Emphasis is on the role of membrane lipid composition in these processes and in the translocation of antimicrobial peptides...
  42. ncbi The innate immune response of the respiratory epithelium
    G Diamond
    Department of Anatomy, Cell Biology and Injury Sciences, UMDNJ New Jersey Medical School, Newark 07103, USA
    Immunol Rev 173:27-38. 2000
    ..This can lead to increased susceptibility to airway infections...
  43. pmc CAMP: a useful resource for research on antimicrobial peptides
    Shaini Thomas
    Biomedical Informatics Center of Indian Council of Medical Research, National Institute for Research in Reproductive Health, Mumbai, India
    Nucleic Acids Res 38:D774-80. 2010
    ..CAMP will be a useful database for study of sequence-activity and -specificity relationships in AMPs. CAMP is freely available at http://www.bicnirrh.res.in/antimicrobial...
  44. ncbi The inventory of antibiotics in Russian home medicine cabinets
    L S Stratchounski
    Institute of Antimicrobial Chemotherapy, Smolensk State Medical Academy, Smolensk, Russia
    Clin Infect Dis 37:498-505. 2003
    ..8%), intestinal disorders (11.3%), fever (9%), and sore throat (6.8%). According to this study, antibiotics are widely stocked among the general population in Russia, and people use antibiotics in an uncontrolled and imprudent manner...
  45. pmc Isolation and molecular characterization of nalidixic acid-resistant extraintestinal pathogenic Escherichia coli from retail chicken products
    James R Johnson
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55417, USA
    Antimicrob Agents Chemother 47:2161-8. 2003
    ....
  46. ncbi Comparative analysis of antibiotic and antimicrobial biocide susceptibility data in clinical isolates of methicillin-sensitive Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa between 1989 and 2000
    R J W Lambert
    R2 Scientific, Sharnbrook, Bedfordshire, UK
    J Appl Microbiol 97:699-711. 2004
    ..To analyse population minimum inhibitory concentrations (MICs) data from clinical strains of Staphylococcus aureus and Pseudomonas aeruginosa for changes over a 10-year period and to look for correlations between the antimicrobials tested...
  47. ncbi The successful clone: the vector of dissemination of resistance in Streptococcus pneumoniae
    K P Klugman
    Department of International Health, Rollins School of Public Health, Division of Infectious Diseases, School of Medicine, Emory University, 1518 Clifton Road NE, Room 764, Atlanta, GA 30322, USA
    J Antimicrob Chemother 50:1-5. 2002
    ..The molecular basis of resistance to a number of classes of antimicrobials can be used to predict the likelihood of dissemination of the resistance genes...
  48. ncbi Antibiotic resistance among gram-negative bacilli in US intensive care units: implications for fluoroquinolone use
    Melinda M Neuhauser
    Department of Clinical Sciences and Administration, University of Houston College of Pharmacy, Houston, Tex, USA
    JAMA 289:885-8. 2003
    ..Previous surveillance studies have documented increasing rates of antimicrobial resistance in US intensive care units (ICUs) in the early 1990s...
  49. ncbi DNA minor groove binders as potential antitumor and antimicrobial agents
    Pier Giovanni Baraldi
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, 44100 Ferrara, Italy
    Med Res Rev 24:475-528. 2004
    ....
  50. ncbi Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima
    Ren Lai
    Department of Animal Toxinology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, People s Republic of, Yunnan, China
    Peptides 23:427-35. 2002
    ..Peptides in the second group, termed maximins H1, H2, H3 and H4, are homologous with bombinin H peptides. cDNA sequences revealed that one maximin peptide plus one maximin H peptide derived from a common larger protein...
  51. ncbi In vitro susceptibilities of bacterial ocular isolates to fluoroquinolones
    A Graves
    Santen, Inc, Napa, California 94558, USA
    Cornea 20:301-5. 2001
    ..To evaluate and compare the in vitro antimicrobial activity of levofloxacin versus ciprofloxacin and ofloxacin against ocular isolates from patients with bacterial conjunctivitis...
  52. ncbi Tigecycline: first of a new class of antimicrobial agents
    Warren E Rose
    Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
    Pharmacotherapy 26:1099-110. 2006
    ..Tigecycline has demonstrated promising results in initial in vitro and clinical studies for SSSIs and complicated intraabdominal infections; however, further clinical experience will clarify its role as a broad-spectrum agent...
  53. pmc Histone H4 is a major component of the antimicrobial action of human sebocytes
    Dong Youn Lee
    Division of Dermatology, University of California San Diego and VA San Diego Healthcare Center, San Diego, California, USA
    J Invest Dermatol 129:2489-96. 2009
    ..Taken together, these results indicate that the release of histone H4 by holocrine secretion from the sebaceous gland may play an important role in innate immunity...
  54. ncbi Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients
    M H Kollef
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Chest 115:462-74. 1999
    ..To evaluate the relationship between inadequate antimicrobial treatment of infections (both community-acquired and nosocomial infections) and hospital mortality for patients requiring ICU admission...
  55. pmc Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs
    R Bals
    Institute for Human Gene Therapy, Department of Medicine and Molecular and Cellular Engineering, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Infect Immun 67:3542-7. 1999
    ..These similarities between murine and human host defense apparatus provide further impetus to evaluate the mouse as a model for studying the human innate host defense system...
  56. pmc Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance
    X S Pan
    Molecular Genetics Group, Department of Cellular and Molecular Sciences, St George s Hospital Medical School, University of London, United Kingdom
    J Bacteriol 178:4060-9. 1996
    ..These results suggest that DNA topoisomerase IV is an important target for fluoroquinolones in S. pneumoniae and establish this organism as a useful gram-positive system for resistance studies...
  57. pmc Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterat
    S Brisse
    Eijkman Winkler Institute, Utrecht University, 3584 CX, Utrecht, The Netherlands
    Antimicrob Agents Chemother 43:2051-5. 1999
    ..Irrespective of the alterations in GyrA and ParC proteins, clinafloxacin exhibited greater activity than all other fluoroquinolones tested against K. pneumoniae and E. aerogenes...
  58. ncbi Effect of drotrecogin alfa (activated) on human endothelial cell permeability and Rho kinase signaling
    Wei Zeng
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Crit Care Med 32:S302-8. 2004
    ....
  59. ncbi Suppression of human prostate cancer cell growth by ciprofloxacin is associated with cell cycle arrest and apoptosis
    Olivia Aranha
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Int J Oncol 22:787-94. 2003
    ..Based on our in vitro results, further in-depth in vivo animal or human investigations are warranted...
  60. pmc Drotrecogin alfa (activated): real-life use and outcomes for the UK
    Kathryn M Rowan
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, London WC1H 9HR, UK
    Crit Care 12:R58. 2008
    ..1% absolute reduction in 28-day mortality. Drotrecogin alfa (activated; DrotAA) was subsequently approved for use in patients with severe sepsis...
  61. ncbi Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites
    Ikhlas A El Karim
    Oral Science Research Centre, School of Medicine and Dentistry, Queen s University Belfast, BT12 6BP, Northern Ireland, UK
    J Neuroimmunol 200:11-6. 2008
    ..aureus. These antimicrobial activities add a further dimension to the immunomodulatory roles for neuropeptides in the inflammatory and immune responses...
  62. ncbi Mutations in the dihydropteroate synthase gene of human-derived Pneumocystis carinii isolates from Italy are infrequent but correlate with prior sulfa prophylaxis
    Liang Ma
    Critical Care Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1662, USA
    J Infect Dis 185:1530-2. 2002
    ..The study confirms the association between DHPS mutations and prior sulfa prophylaxis and shows that the prevalence of DHPS mutations in an Italian patient population is lower than that in other populations...
  63. pmc Anti-microbial properties of histone H2A from skin secretions of rainbow trout, Oncorhynchus mykiss
    Jorge M O Fernandes
    Gatty Marine Laboratory, School of Biology, University of St Andrews, Fife KY16 8LB, Scotland, U K
    Biochem J 368:611-20. 2002
    ..This is the first report to show that, in addition to its classical function in the cell, histone H2A has extremely strong anti-microbial properties and could therefore help contribute to protection against bacterial invasion...
  64. pmc Genetic characterization of highly fluoroquinolone-resistant clinical Escherichia coli strains from China: role of acrR mutations
    H Wang
    Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, People's Republic of China
    Antimicrob Agents Chemother 45:1515-21. 2001
    ..5- to 6-fold. This study shows that mutations in acrR are an additional genetic basis for fluoroquinolone resistance...
  65. pmc Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli
    P Heisig
    Pharmazeutische Mikrobiologie, Universitat Bonn, Germany
    Antimicrob Agents Chemother 40:879-85. 1996
    ..coli requires at least one parC mutation in addition to the gyrA mutation(s)...
  66. ncbi Mechanisms of adrenomedullin antimicrobial action
    Robert P Allaker
    Oral Microbiology, Institute of Cell and Molecular Science, Queen Mary, University of London, Newark Street, London E1 2AT, UK
    Peptides 27:661-6. 2006
    ..05) more active. It is suggested that postsecretory processing may generate multiple AM congeners that have enhanced antimicrobial activities against a range of potential targets...
  67. ncbi Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, MB, Canada
    Crit Care Med 34:1589-96. 2006
    ..To determine the prevalence and impact on mortality of delays in initiation of effective antimicrobial therapy from initial onset of recurrent/persistent hypotension of septic shock...
  68. ncbi 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer
    Walter T Hughes
    St Jude Children s Research Hospital, Memphis, TN, 38105, USA
    Clin Infect Dis 34:730-51. 2002
  69. pmc Studies on anticancer activities of antimicrobial peptides
    David W Hoskin
    Department of Pathology and Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Biochim Biophys Acta 1778:357-75. 2008
    ..In this article, we review various studies on different AMPs that exhibit cytotoxic activity against cancer cells. The suitability of cancer cell-targeting AMPs as cancer therapeutics is also discussed...
  70. ncbi Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations
    Manuel N Melo
    Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av Professor Egas Moniz, Lisbon, Portugal
    Nat Rev Microbiol 7:245-50. 2009
    ..Strong membrane-binding and micromolar therapeutic concentrations of AMPs indicate that membrane-bound concentrations may be reached that are higher than intuitively expected, triggering disruptive effects on bacteria...
  71. ncbi High-dose, short-course levofloxacin for community-acquired pneumonia: a new treatment paradigm
    Lala M Dunbar
    Louisiana State University Medical Center, New Orleans, Louisiana, USA
    Clin Infect Dis 37:752-60. 2003
    ..2% and 92.4% in the 750-mg and 500-mg groups, respectively. These data demonstrate that 750 mg of levofloxacin per day for 5 days is at least as effective as 500 mg per day for 10 days for treatment of mild-to-severe CAP...
  72. ncbi Restricting the selection of antibiotic-resistant mutants: a general strategy derived from fluoroquinolone studies
    X Zhao
    Public Health Research Institute, New York, NY 10016, USA
    Clin Infect Dis 33:S147-56. 2001
    ..Application of these principles could drastically restrict the selection of drug-resistant pathogens...
  73. pmc Drug-resistant Salmonella enterica serotype paratyphi A in India
    D S Chandel
    All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Emerg Infect Dis 6:420-1. 2000
    ..Paratyphi A abruptly increased in the New Delhi region. In the first 6 months of 1999, 32% of isolates were resistant to both chloramphenicol and cotrimoxazole and another 13% were resistant to more than two antibiotics...
  74. ncbi Treatment of Q fever endocarditis: comparison of 2 regimens containing doxycycline and ofloxacin or hydroxychloroquine
    D Raoult
    Unite des Rickettsies, Faculte de Medecine, Université de la Mediterranée CNRS, Marseille, France
    Arch Intern Med 159:167-73. 1999
    ..Q fever endocarditis, caused by Coxiella burnetii, is fatal in 25% to 60% of patients. Currently, treatment with a long-term tetracycline and quinolone regimen for at least 4 years is recommended, although relapses are frequent...
  75. ncbi Fluoroquinolone resistance among Gram-positive cocci
    David C Hooper
    Division of Infectious Diseases, Infection Control Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 2696, USA
    Lancet Infect Dis 2:530-8. 2002
    ....
  76. ncbi Phylogenetic origin and virulence genotype in relation to resistance to fluoroquinolones and/or extended-spectrum cephalosporins and cephamycins among Escherichia coli isolates from animals and humans
    James R Johnson
    Medical Service, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    J Infect Dis 188:759-68. 2003
    ..Thus, in E. coli, antibiotic resistance predicts phylogenetic background and virulence potential in a complex, context-dependent fashion...
  77. ncbi The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection
    Milan Chromek
    Department of Clinical Microbiology, Microbiology and Tumorbiology Center, Karolinska University Hospital and Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Nat Med 12:636-41. 2006
    ..In addition, clinical E. coli strains that were more resistant to LL-37 caused more severe urinary tract infections than did susceptible strains. Thus, cathelicidin seems to be a key factor in mucosal immunity of the urinary tract...
  78. pmc Expression of lux genes in a clinical isolate of Streptococcus pneumoniae: using bioluminescence to monitor gemifloxacin activity
    S J Beard
    Faculty of Applied Sciences, University of the West of England, United Kingdom
    Antimicrob Agents Chemother 46:538-42. 2002
    ..Light output was correlated with measurements of optical density and viable counts during exponential growth and provided a sensitive, real-time measure of the pharmacodynamics of the fluoroquinolone gemifloxacin...
  79. ncbi Initiating co-trimoxazole prophylaxis in HIV-infected patients in Africa: an evaluation of the provisional WHO/UNAIDS recommendations
    M Badri
    Infectious Diseases Clinical Research Unit, Lung Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    AIDS 15:1143-8. 2001
    ..Further studies are needed to assess the optimal time of commencement of prophylaxis, as widespread co-trimoxazole use will lead to increasing antimicrobial resistance to other major pathogens in Africa...
  80. pmc In vitro and in vivo activities of levofloxacin against biofilm-producing Pseudomonas aeruginosa
    H Ishida
    New Product Research Laboratories I, Daiichi Pharmaceutical Co, Ltd, Tokyo, Japan
    Antimicrob Agents Chemother 42:1641-5. 1998
    ..These findings suggest the significant role of levofloxacin in therapy of biofilm bacterium-associated infectious diseases...
  81. pmc Origin of plasmid-mediated quinolone resistance determinant QnrA
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78, rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 49:3523-5. 2005
    ..Shewanella algae, an environmental species from marine and fresh water, was identified as its reservoir. This is a one of the very few examples of progenitor identification of an acquired antibiotic resistance gene...
  82. ncbi Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus
    Vanesa C Albiol Matanic
    Laboratorio de Virologia, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon II, Piso 4, C1428BGA Buenos Aires, Argentina
    Int J Antimicrob Agents 23:382-9. 2004
    ....
  83. pmc Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells
    C Herold
    Department of Medicine I, University of Erlangen Nuernberg, Krankenhausstr 12, D 91054 Erlangen, Germany
    Br J Cancer 86:443-8. 2002
    ..Therefore, qualification of ciprofloxacin as adjunctive agent for colorectal cancer should be evaluated...
  84. ncbi Effect of co-trimoxazole prophylaxis on morbidity, mortality, CD4-cell count, and viral load in HIV infection in rural Uganda
    Jonathan Mermin
    CDC Uganda, Global AIDS Program, National Center for HIV, STD and TB Prevention, National Center for Infectious Diseases Centers for Disease Control and Prevention, Atlanta, GA, USA
    Lancet 364:1428-34. 2004
    ..We assessed the effect of such prophylaxis on morbidity, mortality, CD4-cell count, and viral load among people with HIV infection living in rural Uganda, an area with high rates of bacterial resistance to co-trimoxazole...
  85. ncbi Determining the feasibility of utilizing the microbicide applicator compliance assay for use in clinical trials
    Andrea R Wallace
    Population Council, New York, NY 10021, USA
    Contraception 76:53-6. 2007
    ..In addition, trypan blue is carcinogenic and thus potentially hazardous to technicians spraying daily...
  86. ncbi Properties and applications of antimicrobial peptides in biodefense against biological warfare threat agents
    Raymond Murray Dawson
    DSTO Defense Science and Technology Organisation, Melbourne, Australia
    Crit Rev Microbiol 34:89-107. 2008
    ..Synthesis of these peptides in multivalent form leads to a synergistic increase in antibacterial activity. Strategies to enhance the potency, stability, and selectivity of AMPs are discussed...
  87. ncbi The cDNA of the neutrophil antibiotic Bac5 predicts a pro-sequence homologous to a cysteine proteinase inhibitor that is common to other neutrophil antibiotics
    M Zanetti
    Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Universita di Trieste, Italy
    J Biol Chem 268:522-6. 1993
    ..The COOH-terminal sequences of these antibiotics are completely unrelated. The proregion also exhibits remarkable similarity to pig cathelin, an inhibitor of cathepsin L, indicating a common evolutionary origin...
  88. ncbi Identification and functional characterization of three chicken cathelicidins with potent antimicrobial activity
    Yanjing Xiao
    Department of Animal Science, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    J Biol Chem 281:2858-67. 2006
    ..Their broad spectrum and salt-insensitive antibacterial activities, coupled with their potent LPS-neutralizing activity, make fowlicidins excellent candidates for novel antimicrobial and anti-sepsis agents...
  89. pmc What is the real role of antimicrobial polypeptides that can mediate several other inflammatory responses?
    Peter Elsbach
    Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Clin Invest 111:1643-5. 2003
    ..Their role is now widening following evidence that one such multifunctional peptide, LL-37, induces angiogenesis, a process essential for host defense, wound healing, and tissue repair...
  90. ncbi Structural features and biological activities of the cathelicidin-derived antimicrobial peptides
    R Gennaro
    Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Universita di Trieste, Via Giorgieri, 1, 34127 Trieste, Italy
    Biopolymers 55:31-49. 2000
    ....
  91. ncbi Primate defensins
    Robert I Lehrer
    Department of Medicine and Molecular Biology Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    Nat Rev Microbiol 2:727-38. 2004
    ..Here, their discovery and recent advances in understanding their properties and functions are described...
  92. pmc Papillomavirus microbicidal activities of high-molecular-weight cellulose sulfate, dextran sulfate, and polystyrene sulfonate
    N D Christensen
    The Jake Gittlen Cancer Research Institute and Department of Pathology, The Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 45:3427-32. 2001
    ..These data indicate that the polysulfated and polysulfonated compounds may be useful nontoxic microbicidal compounds that are active against a variety of sexually transmitted disease agents including papillomaviruses...
  93. ncbi The first antimicrobial peptide from sea amphibian
    Yi Lu
    College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China
    Mol Immunol 45:678-81. 2008
    ..The current results reported a new family of amphibian antimicrobial peptide and the first antimicrobial peptide from sea amphibian...
  94. pmc Efficacy of Carraguard-based microbicides in vivo despite variable in vitro activity
    Stuart G Turville
    Center for Biomedical Research, HIV and AIDS Program, Population Council, New York, New York, United States of America
    PLoS ONE 3:e3162. 2008
    ..This work also underscores the potential of Carraguard-based formulations for the delivery of anti-viral drugs to prevent vaginal HIV infection...
  95. ncbi Identification, cloning, characterization and recombinant expression of an anti-lipopolysaccharide factor from the hemocytes of Indian mud crab, Scylla serrata
    Roshan Dinesh Yedery
    Division of Molecular Immunology, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Jehangir Merwanji Street, Parel, Mumbai 400 012, India
    Fish Shellfish Immunol 27:275-84. 2009
    ..These studies strongly suggest that SsALF is one among the important antimicrobial factors produced in the crab during a microbial invasion...
  96. ncbi Spread of ampicillin/vancomycin-resistant Enterococcus faecium of the epidemic-virulent clonal complex-17 carrying the genes esp and hyl in German hospitals
    I Klare
    Robert Koch Institute, Wernigerode Branch, Burgstr 37, 38855, Wernigerode, Germany
    Eur J Clin Microbiol Infect Dis 24:815-25. 2005
    ..In conclusion, it is very important to monitor the occurrence of epidemic-virulent clonal complex-17 strains of E. faecium to prevent their spread in hospitals, especially if they are resistant to glycopeptides and linezolid...
  97. ncbi Antimicrobial peptides of vertebrates
    T Ganz
    Department of Medicine, University of California School of Medicine, Los Angeles 90095 1690, USA
    Curr Opin Immunol 10:41-4. 1998
    ..Other highlights included new insights into the relative selectivity of antimicrobial peptides for microbial membranes, their primary site of action...
  98. ncbi Hyastatin, a glycine-rich multi-domain antimicrobial peptide isolated from the spider crab (Hyas araneus) hemocytes
    Sigmund V Sperstad
    Department of Marine Biotechnology, University of Tromsø, Norway
    Mol Immunol 46:2604-12. 2009
    ..Both hyastatin and the N-terminal region had the ability to bind chitin. Conclusively, this indicates the importance of the Cys-containing region for the antimicrobial activity, and a possible multifunctional character of hyastatin...
  99. ncbi Relish, a central factor in the control of humoral but not cellular immunity in Drosophila
    M Hedengren
    Umeå Center for Molecular Pathogenesis, Umea University, Sweden
    Mol Cell 4:827-37. 1999
    ..Our results illustrate the importance of the humoral response in Drosophila immunity and demonstrate that Relish plays a key role in this response...
  100. pmc Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates
    J Engberg
    Department of Gastrointestinal Infections, Division of Diagnostics, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    Emerg Infect Dis 7:24-34. 2001
    ....
  101. ncbi Prevention of intravascular catheter-related infections
    L A Mermel
    Division of Infectious Diseases, Rhode Island Hospital and Brown University School of Medicine, Providence 02903, USA
    Ann Intern Med 132:391-402. 2000
    ..To review the literature on prevention of intravascular catheter-related infections...

Research Grants64

  1. Carbohydrate-based Antiinfective Agents
    Chi Huey Wong; Fiscal Year: 2013
    ..A strategy for a carbohydrate-modified HA protein vaccine is presented, with attention directed toward maximizing cross-reactive immunity. ..
  2. Pathogen-Specific Regulation of Protein Assembly
    ALLEN BERNARD REITZ; Fiscal Year: 2010
    ..We first seek to apply our strategy to the discovery of agents to treat Yersinia enterocolitica, an NIAID Category B priority pathogen. ..
  3. Cell Surface Protein Anchoring and Function in Gram-Positive Bacteria
    ROBERT THOMPSON CLUBB; Fiscal Year: 2013
    ..Collectively, this research will increase our understanding of the molecular basis of S. aureus pathogenesis and it could lead to new therapeutics to treat bacterial infections. ..
  4. Discovering New Anti-Infective Agents from Lysobacter
    Liangcheng Du; Fiscal Year: 2013
    ..The deciphering of the biosynthetic mechanism for these structurally distinct and biologically active products will allow for designing rational strategiesin the development of the products as new anti-infectives. ..
  5. Targeting DXP Synthase in Non-mammalian Isoprenoid Biosynthesis
    FRANCINE M MORRIS; Fiscal Year: 2012
    ..The long term goal is to develop novel, potent and broad-based anti-microbial agents that also exhibit limited toxicity to the human host. ..
  6. Viral and Microbial RNA Modifying Enzymes
    STEWART H SHUMAN; Fiscal Year: 2013
    ....
  7. Targeting a Unique Enzyme Mechanism in Non-Mammalian Isoprenoid Biosynthesis
    Jessica M Smith; Fiscal Year: 2013
    ..The rationale for the proposed studies is that developing strategies for selective inhibition of this enzyme will provide new tools for investigating this essential pathway in pathogens and will lead to new anti-infective agents. ..
  8. Oligosaccharides to Prevent Infectious Diarrhea
    JOHN MICHAEL MCCOY; Fiscal Year: 2012
    ..abstract_text> ..
  9. ADHESIN-BASED NANOTHERAPEUTICS IN URINARY TRACT INFECTION
    DAVID ALAN HUNSTAD; Fiscal Year: 2013
    ..We will evaluate the ability of these nanoparticles to prevent and treat UTI. ..
  10. AGE-RELATED GASTRIC CHANGES AND DRUG ABSORPTION
    Aryeh Hurwitz; Fiscal Year: 1993
    ..Extension of such studies to other classes of drugs will make possible rational prediction of altered drug bioavailability in the elderly...
  11. Hemoglobin Capture and Heme Acquisition by the Pathogen Staphylococcus Aureus
    MEGAN MARIE SJODT; Fiscal Year: 2013
    ..The results of this research could therefore facilitate the development of anti-infective agents that work by inhibiting heme acquisition. ..
  12. Quality Control of Protein Translation
    A Wali Karzai; Fiscal Year: 2012
    ..Ultimately, these insights will have implications for a better understanding of a variety of cellular processes, including control of gene expression, synthesis and degradation of proteins, and the targeted decay defective mRNAs. ..
  13. Prenyl Synthase Inhibitors: Novel Anti-Infective Agents
    Eric Oldfield; Fiscal Year: 2013
    ..Focus will be on developing inhibitors for three unique targets in malaria parasites, and on the use of novel drugs against sleeping sickness. ..
  14. Design and analysis of random copolymers with antimicrobial activity
    James C Weisshaar; Fiscal Year: 2013
    ..Random copolymers may find applications in the context of antifungal activity, antiplasmodial activity, and lung-surfactant activity as well. ..
  15. The multiple states of IpaB Shigella type III secretion
    William D Picking; Fiscal Year: 2013
    ..This study is anticipated to reveal mechanistic aspects of T3SS may be targeted by anti-infective agents. ..
  16. ANTIFUNGAL RESPONSE--MDR INDUCTION
    Thomas Edlind; Fiscal Year: 2002
    ..Candida homologues of these factors will be identified by PCR or expression in S. cerevisiae. Their role in MDR induction will be examined by gene disruption. ..
  17. Development of RSK Inhibitors as Novel Therapeutics for Yersinia pestis
    Jeffrey Smith; Fiscal Year: 2010
    ..The proposed research is designed to develop our novel anti-infective agent toward clinical application as an anti-Yersinia pestis agent. ..
  18. ESAT-6 Secretion in Staphylococcus Aureus
    Dominique M Missiakas; Fiscal Year: 2013
    ..Moreover, staphylococcal esxB mutants are interrogated for the genetic requirements of generating protective immunity against S. aureus disease. ..
  19. Chemical Synthesis of Bioactive Flavonoid and Xanthone-Derived Natural Products
    John A Porco; Fiscal Year: 2013
    ....
  20. Synthesis of Anti-Infective Agents
    K C Nicolaou; Fiscal Year: 2013
    ..Therefore, the work is expected to have a broad and positive impact on chemistry, biology, and medicine. ..
  21. Membrane Permeable Diphosphate Analogs Targeting Pathogen Isoprenoid Biosynthesis
    CAREN L MEYERS; Fiscal Year: 2013
    ..These studies will provide a foundation for the transformation of highly polar, potent inhibitors of isoprenoid biosynthesis into useful therapeutic agents for the treatment of infectious diseases. ..
  22. Tight Adherence Genes of a Periodontal Pathogen
    David H Figurski; Fiscal Year: 2012
    ..These chemicals may be developed into new antibiotic drugs, supporting therapy for multiple types of infection. ..
  23. Novel Inhibitors to DHPS to Probe Catalytic Mechanism &Therapeutic Potential - r
    Stephen W White; Fiscal Year: 2013
    ..aureus and P. jirovecii that have emerged as particularly problematical infectious disease agents in the U.S. in recent years. ..
  24. Mechanistic analysis of flavonoids on bacterial virulence
    Howard C Hang; Fiscal Year: 2013
    ..Given the emergence of new and antibiotic-resistant bacterial pathogens, our studies should afford new anti-infective agents combat bacterial infections in humans. ..
  25. Engineered Probiotic Yeast to Prevent Infectious Diarrhea
    John McCoy; Fiscal Year: 2009
    ..The surface ??(1,2) fucosylated probiotic K.lactis that is the subject of this application will target both Norwalk-like viruses and C.jejuni, as well as other fucose-binding enteropathogens. ..
  26. Safety Evaluation of Anti-Infective Agents
    Jon Mirsalis; Fiscal Year: 2013
    ..The scope of this effort is to evaluate the toxicity and pharmacokinetics of potential chemical and biological therapies for AIDS and other infectious diseases in various laboratory animal species. ..
  27. Safety Evaluation of Anti-Infective Agents
    Jon Mirsalis; Fiscal Year: 2010
    ..The scope of this effort is to evaluate the toxicity and pharmacokinetics of potential chemical and biological therapies for AIDS and other infectious diseases in various laboratory animal species. ..
  28. Safety Evaluation of Anti-Infective Agents
    Jon Mirsalis; Fiscal Year: 2011
    ..The scope of this effort is to evaluate the toxicity and pharmacokinetics of potential chemical and biological therapies for AIDS and other infectious diseases in various laboratory animal species. ..
  29. Safety Evaluation of Anti-Infective Agents
    Jon Mirsalis; Fiscal Year: 2012
    ..The scope of this effort is to evaluate the toxicity and pharmacokinetics of potential chemical and biological therapies for AIDS and other infectious diseases in various laboratory animal species. ..
  30. CONTAINMENT FACILITIES FOR ANIMAL HOUSING AND RESEARCH
    MICHAEL DINGERSON; Fiscal Year: 1992
    ..In this interim period (1992-1995), it is critical that this institution maintain and extend its commitment to the provision of suitable facilities in support of our animal research programs in biomedical science...
  31. Targeting Non-mammalian Isoprenoid Biosynthesis
    CAREN L MEYERS; Fiscal Year: 2013
    ..Anti-infective agents developed to target these enzymes have the potential to broadly impact the treatment of deadly infectious diseases. ..
  32. HTS on Riboflavin and Terpene Biosynthetic Enzymes(RMI)
    Adelbert Bacher; Fiscal Year: 2005
    ..Follow-up work in cooperation with Prof. Cushman will be directed at the development of candidate compounds into actual anti-infective drugs by medicinal chemistry methods. ..
  33. Dev & Testing of New Medications for Treatment of Emerging Infectious Diseases
    Mitchell Avery; Fiscal Year: 2006
    ..This allows LADDS infrastructure to inch forward now to the last stages of drug development that are achievable with academic economics. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  34. GENERATION OF KETOLIDES BY COMBINATORIAL BIOSYNTHESIS
    Yongquan Xue; Fiscal Year: 1999
    ..abstract_text> ..
  35. DETERMINANTS IN PLATELET MICROBICIDAL PROTEINS
    Michael Yeaman; Fiscal Year: 2004
    ..Thus, these studies will significantly advance our understanding of antimicrobial host defense, and may yield new modes for its amplification. ..
  36. Sortase A anchoring mechanism
    DEBORAH LEON ROSSELL; Fiscal Year: 2007
    ..Work leading to the creation of anti-infective agents against pathogenic bacteria should be prioritized especially in an era where bacteria have developed a resistance to many commonly used antibiotics. [unreadable] [unreadable]..
  37. APPROACHES TO CHARACTERIZATION OF ANTIINFECTIVE AGENTS
    Mark Hamann; Fiscal Year: 2002
    ..SAR studies will be conducted utilizing chemical and microbial transformations of biologically active secondary metabolites combined with molecular modeling studies. ..
  38. Improving Glycosyltransferase by RACHITT Gene Shuffling
    Yongquan Xue; Fiscal Year: 2001
    ..This will be a key step in combinatorial biosynthesis of ketolide antibiotics that have a potential to combat multi-drug resistant bacterial pathogens. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  39. Anti-infectives with Multi-domain Ribosomal Binding
    Leonard Katz; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATION: Clinical development candidates could be commericialized as anti-infective agents only after approval by the appropriate regulatory authorities...
  40. SYNTHESIS OF ANTIINFECTIVE AGENTS
    Samuel Danishefsky; Fiscal Year: 2002
    ..The scope of this inquiry includes lipid conjugates to replace (or augment) KLH, clustered presentations to mimic antigen as presentations in mucins, and antigen analogs in the hope of triggering more aggressive immune responses. ..
  41. RNA-Targeted Antimicobial Agents
    JING SHEN DENG; Fiscal Year: 2003
    ..Successful completion of this Phase II research will lead to the identification of a new class of anti-infective agents. ..
  42. RESYNTHESIS OF THERAPEUTIC AGENTS FOR TREAT. OF INFECT
    JAROSLAV NOVOTNY; Fiscal Year: 2000
    ....
  43. Structure-Based Design of Bacterial GTPase Inhibitors
    Mark Shenderovich; Fiscal Year: 2004
    ..abstract_text> ..
  44. Novel Single, Dual and Multitargeted Inhibitors of RTKs
    Aleem Gangjee; Fiscal Year: 2007
    ..abstract_text> ..
  45. STRUCTURE BASED ANALOGS AS ANTIOPPORTUNISTIC AGENTS
    Aleem Gangjee; Fiscal Year: 2001
    ..The analogues synthesized will also be submitted for screening against tuberculosis (NIAID) parasitic diseases (WHO) and tumor cells in culture (NCI). ..
  46. Third Generation Antiopportunistic Agents
    Aleem Gangjee; Fiscal Year: 2003
    ..Screening against tuberculosis (NIAID) and tumor cells in culture (NCI) is also proposed. ..
  47. Antitumor Antimitotics That Reverse Tumor Resistance
    Aleem Gangjee; Fiscal Year: 2010
    ..The study will also further define the mechanism of action of the novel series and could afford agents for clinical use. ..
  48. NOVEL NONINDUCIBLE THYMIDYLATE SYNTHASE INHIBITORS
    Aleem Gangjee; Fiscal Year: 2004
    ....
  49. Neuroprotective Role of Fetuin in Cerebral Ischemia
    Haichao Wang; Fiscal Year: 2008
    ..Answers to these questions will improve our understanding of the pathophysiology of ischemic neural injury, and identify novel therapeutic agents for the treatment of stroke and related disorders. ..
  50. Novel, P. jirovecii Specific Antipneumocystis Agents
    Aleem Gangjee; Fiscal Year: 2009
    ..These agents could be used alone or in combination to treat PCP thus providing novel agents against a new target. ..
  51. Single Agents with Designed Combination Chemotherapy Potential
    Aleem Gangjee; Fiscal Year: 2010
    ..abstract_text> ..
  52. A Contextual Model of Microbicide Acceptability
    Kathleen Morrow; Fiscal Year: 2005
    ..abstract_text> ..
  53. Linking Biophysical Functions of Microbicides to User Perception & Acceptability
    Kathleen Morrow; Fiscal Year: 2007
    ..In sum, this work will contribute methodology leading to rational design of microbicide formulations that co-optimize vaginal distribution and retention with user acceptability. ..
  54. Alpha Folate Receptor Mediated GARFTase Inhibitors as Selective Antitumor Agents
    Aleem Gangjee; Fiscal Year: 2010
    ....
  55. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
  56. Mechanism of Action of Novel Dual Actiing Pyrimidinediones
    Robert Buckheit; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  57. Improved Macaque Safety Model for Topical Microbicides: Post-coital Assessments
    Dorothy Patton; Fiscal Year: 2008
    ..In addition, we will collect parallel assessments, when mating has occurred with a placebo gel (HEC universal placebo) in place. These studies will provide urgently needed data regarding topical microbicide use with coital activity. ..
  58. Innate Immunity and exacerbations of COPD
    Sanjay Sethi; Fiscal Year: 2009
    ..The overall goal of this research is to identify specific aspects of the innate defense of the lung that determine the frequency of exacerbations in COPD that will serve as potential therapeutic targets to reduce exacerbations. ..
  59. Therapeutic Development of Antimicrobial Biomimetics
    Richard Scott; Fiscal Year: 2008
    ..The projected use for the developed product is as an iv injectable antibiotic to treat hospital-acquired infections. [unreadable] [unreadable] [unreadable]..
  60. Enhancing HIV Medication Adherence in India
    DEBORAH LYNNE JONES; Fiscal Year: 2010
    ....
  61. Pediatric HIV-encephalopathy in DRC: effect of ART & role of compartmentalization
    Annelies Van Rie; Fiscal Year: 2010
    ....
  62. Mechanisms of HIV Transport Across the BBB
    William Banks; Fiscal Year: 2004
    ....
  63. Oral Immunology/Microbiology Research Group Annual Mtg
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  64. Ethanol, Tat and the Blood-brain barrier
    Kwang Kim; Fiscal Year: 2004
    ..e., nitric oxide and signaling pathways. The information derived from this proposal should enhance our understanding of the role of ethanol in HIV-1 neuropthogenesis. ..