female fertility agents

Summary

Summary: Compounds which increase the capacity to conceive in females.

Top Publications

  1. ncbi N-Acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross-over trial
    Ahmed Badawy
    Department of Obstetrics and Gynaecology, Mansoura University, Mansoura, Egypt
    Acta Obstet Gynecol Scand 86:218-22. 2007
  2. ncbi Minimal ovarian stimulation with clomiphene citrate: a large-scale retrospective study
    Shokichi Teramoto
    Kato Ladies Clinic, 7 20 3, Nishishinjuku, Shinjuku, Tokyo 160 0023, Japan
    Reprod Biomed Online 15:134-48. 2007
  3. ncbi Association between fertility drugs and gynecologic cancers, breast cancer, and childhood cancers
    Ali Ayhan
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Hacettepe, Ankara, Turkey
    Acta Obstet Gynecol Scand 83:1104-11. 2004
  4. ncbi A randomized controlled trial of laparoscopic ovarian diathermy versus gonadotropin therapy for women with clomiphene citrate-resistant polycystic ovary syndrome
    Cynthia M Farquhar
    Department of Obstetrics and Gynaecology, University of Auckland, National Women s Hospital, Auckland, New Zealand
    Fertil Steril 78:404-11. 2002
  5. ncbi Risk of breast cancer after exposure to fertility drugs: results from a large Danish cohort study
    Allan Jensen
    Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark
    Cancer Epidemiol Biomarkers Prev 16:1400-7. 2007
  6. ncbi Infertility, fertility drugs, and ovarian cancer: a pooled analysis of case-control studies
    Roberta B Ness
    University of Pittsburgh School of Public Health, Pittsburgh, PA 15261, USA
    Am J Epidemiol 155:217-24. 2002
  7. ncbi Infertility drugs and the risk of breast cancer: findings from the National Institute of Child Health and Human Development Women's Contraceptive and Reproductive Experiences Study
    Ronald T Burkman
    National Cancer Institute Surveillance, Epidemiology, and End Results Registry, Department of Obstetrics and Gynecology, Henry Ford Health System, Detroit, Michigan, USA
    Fertil Steril 79:844-51. 2003
  8. ncbi Uterine cancer after use of clomiphene citrate to induce ovulation
    Michelle D Althuis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7234, USA
    Am J Epidemiol 161:607-15. 2005
  9. ncbi Ovarian cancer risk after the use of ovulation-stimulating drugs
    Louise A Brinton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 7068, Bethesda, MD 20852 7234, USA
    Obstet Gynecol 103:1194-203. 2004
  10. ncbi Ovarian response and pregnancy outcome in poor-responder women: a randomized controlled trial on the effect of luteinizing hormone supplementation on in vitro fertilization cycles
    Gorka Barrenetxea
    Center for Reproductive Medicine and Infertility Quirón Bilbao, Bilbao, Spain
    Fertil Steril 89:546-53. 2008

Research Grants

  1. INSULIN RESISTANCE IN PCOS--SEQUELAE AND TREATMENT
    RICHARD LEGRO; Fiscal Year: 2005
  2. Effect of Continuous vs. Sequential Oral Contraception
    RICHARD LEGRO; Fiscal Year: 2004
  3. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2003
  4. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2010
  5. Characterizing Mammalian Embryonic polyA Binding Protein
    Emre Seli; Fiscal Year: 2008
  6. GONADOTROPIN-RELEASING HORMONE ACTION
    P Michael Conn; Fiscal Year: 2008
  7. Steroid Hormone Genes and Ovarian Cancer Risk
    Mary Anne Rossing; Fiscal Year: 2010
  8. Progesterone Modulation of Pulsatile GnRH Secretion
    CHRISTOPHER MCCARTNEY; Fiscal Year: 2007
  9. HOX GENE EXPRESSION IN HUMAN ENDOMETRIUM
    Hugh Taylor; Fiscal Year: 2007
  10. NEUROBIOLOGICAL EFFECT OF LONG-TERM ESTROGEN REPLACEMENT
    Yolanda Smith; Fiscal Year: 2006

Detail Information

Publications225 found, 100 shown here

  1. ncbi N-Acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross-over trial
    Ahmed Badawy
    Department of Obstetrics and Gynaecology, Mansoura University, Mansoura, Egypt
    Acta Obstet Gynecol Scand 86:218-22. 2007
    ..To compare clomiphene citrate plus N-acetyl cysteine versus clomiphene citrate for inducing ovulation in patients with polycystic ovary syndrome...
  2. ncbi Minimal ovarian stimulation with clomiphene citrate: a large-scale retrospective study
    Shokichi Teramoto
    Kato Ladies Clinic, 7 20 3, Nishishinjuku, Shinjuku, Tokyo 160 0023, Japan
    Reprod Biomed Online 15:134-48. 2007
    ..The mean number of oocytes retrieved was 2.2. The rates for live births, miscarriages, and ectopic pregnancies, in relation to initiated cycles, including cases of frozen-thawed transfer, were 11.1, 3.4 and 0.2% respectively...
  3. ncbi Association between fertility drugs and gynecologic cancers, breast cancer, and childhood cancers
    Ali Ayhan
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Hacettepe, Ankara, Turkey
    Acta Obstet Gynecol Scand 83:1104-11. 2004
    ..Although it is still early to state the last words on this topic, the possible association should be addressed when obtaining an informed consent before starting treatment...
  4. ncbi A randomized controlled trial of laparoscopic ovarian diathermy versus gonadotropin therapy for women with clomiphene citrate-resistant polycystic ovary syndrome
    Cynthia M Farquhar
    Department of Obstetrics and Gynaecology, University of Auckland, National Women s Hospital, Auckland, New Zealand
    Fertil Steril 78:404-11. 2002
    ..To compare the effectiveness of laparoscopic ovarian diathermy with gonadotropin ovulation induction for women with clomiphene citrate-resistant polycystic ovary syndrome...
  5. ncbi Risk of breast cancer after exposure to fertility drugs: results from a large Danish cohort study
    Allan Jensen
    Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark
    Cancer Epidemiol Biomarkers Prev 16:1400-7. 2007
    ..Using data from the largest cohort of infertile women to date, the aim of this study was to examine the effects of fertility drugs on breast cancer risk overall and according to histologic subtypes...
  6. ncbi Infertility, fertility drugs, and ovarian cancer: a pooled analysis of case-control studies
    Roberta B Ness
    University of Pittsburgh School of Public Health, Pittsburgh, PA 15261, USA
    Am J Epidemiol 155:217-24. 2002
    ..10, 2.71) and unknown cause of infertility (OR = 1.19, 95% CI: 1.00, 1.40) increased cancer risk. These data suggest a role for specific biologic causes of infertility, but not for fertility drugs in overall risk for ovarian cancer...
  7. ncbi Infertility drugs and the risk of breast cancer: findings from the National Institute of Child Health and Human Development Women's Contraceptive and Reproductive Experiences Study
    Ronald T Burkman
    National Cancer Institute Surveillance, Epidemiology, and End Results Registry, Department of Obstetrics and Gynecology, Henry Ford Health System, Detroit, Michigan, USA
    Fertil Steril 79:844-51. 2003
    ..To determine the association between infertility drug use and invasive breast cancer in a population-based case-control study...
  8. ncbi Uterine cancer after use of clomiphene citrate to induce ovulation
    Michelle D Althuis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7234, USA
    Am J Epidemiol 161:607-15. 2005
    ..52, 95% CI: 1.5, 108.0). Clomiphene may increase uterine cancer risk, with higher doses leading to higher risk. Long-term follow-up of infertility cohorts is necessary to clarify the association between clomiphene use and uterine cancer...
  9. ncbi Ovarian cancer risk after the use of ovulation-stimulating drugs
    Louise A Brinton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 7068, Bethesda, MD 20852 7234, USA
    Obstet Gynecol 103:1194-203. 2004
    ..To assess the long-term effects of ovulation-stimulating drugs on the risk of ovarian cancer...
  10. ncbi Ovarian response and pregnancy outcome in poor-responder women: a randomized controlled trial on the effect of luteinizing hormone supplementation on in vitro fertilization cycles
    Gorka Barrenetxea
    Center for Reproductive Medicine and Infertility Quirón Bilbao, Bilbao, Spain
    Fertil Steril 89:546-53. 2008
    ..To prospectively assess the effect of using a combination of recombinant follicle-stimulating hormone (rFSH) and recombinant luteinizing hormone (rLH) on ovarian stimulation parameters and treatment outcome among poor-responder patients...
  11. pmc Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial
    Etelka Moll
    Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology, Academic Medical Centre, PO Box 22700, 1100 DE, Amsterdam, Netherlands
    BMJ 332:1485. 2006
    ..To compare the effectiveness of clomifene citrate plus metformin and clomifene citrate plus placebo in women with newly diagnosed polycystic ovary syndrome...
  12. ncbi Early cleavage does not predict treatment outcome following the use of GnRH antagonists in women older than 35
    Wen Jui Yang
    Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
    Fertil Steril 88:1573-8. 2007
    ..To compare the early-cleavage rates and the implantation potential of embryos between the GnRH antagonist and agonist long stimulation protocols in women older than 35 years...
  13. ncbi One versus two inseminations per cycle in intrauterine insemination with sperm from patients' husbands: a systematic review of the literature
    Carmen Osuna
    Department of Obstetrics and Gynecology, Hospital de Cruces, Pais Vasco University, Baracaldo, Vizcaya, Spain
    Fertil Steril 82:17-24. 2004
    ..To study the efficacy of performing two inseminations per cycle in IUI with husband's sperm compared with one insemination per cycle...
  14. ncbi Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, M S Hershey Medical Center, Hershey, PA 17033, USA
    N Engl J Med 356:551-66. 2007
    ..The polycystic ovary syndrome is a common cause of infertility. Clomiphene and insulin sensitizers are used alone and in combination to induce ovulation, but it is unknown whether one approach is superior...
  15. ncbi Stimulated intra-uterine insemination is not a natural choice for the treatment of unexplained subfertility. Current best evidence for the advanced treatment of unexplained subfertility
    John Collins
    Department of Obstetrics and Gynecology, McMaster University, Hamilton and Department of Obstetrics and Gynaecology, Dalhousie University, Halifax, Canada
    Hum Reprod 18:907-12. 2003
    ..A large multicentre factorial trial is needed to evaluate the relative value of existing empiric treatments for unexplained infertility...
  16. ncbi Effect of obesity on recombinant follicle-stimulating hormone absorption: subcutaneous versus intramuscular administration
    Michael P Steinkampf
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35249 7333, USA
    Fertil Steril 80:99-102. 2003
    ..To determine whether recombinant follicle-stimulating hormone (rFSH) should be administered intramuscularly (i.m.) or subcutaneously (s.c.) to obese women...
  17. ncbi GnRH antagonist versus long GnRH agonist protocol in poor responders undergoing IVF: a randomized controlled trial
    Lai Ping Cheung
    Department of Obstetrics and Gynecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Hum Reprod 20:616-21. 2005
    ..This is the first published report of a prospective, randomized, controlled trial comparing a fixed, multi-dose GnRH antagonist protocol with a long GnRH agonist protocol in poor responders undergoing IVF...
  18. ncbi Relationship of baseline ovarian volume to ovarian response in World Health Organization II anovulatory patients who underwent ovulation induction with gonadotropins
    Amir Lass
    Serono International S A, Geneva, Switzerland
    Fertil Steril 78:265-9. 2002
    ..To assess whether ovarian volume of World Health Organization II anovulatory patients in the early follicular phase predicts the response to ovulation induction with gonadotropins...
  19. ncbi A luteal estradiol protocol for anticipated poor-responder patients may improve delivery rates
    Micah J Hill
    Blanchfield Army Community Hospital, Fort Campbell, Kentucky, USA
    Fertil Steril 91:739-43. 2009
    ..To compare IVF data and outcomes between a standard protocol and a luteal phase E(2) protocol...
  20. ncbi Evaluation of a new surgical approach for the treatment of clomiphene citrate-resistant infertility in polycystic ovary syndrome: laparoscopic ovarian multi-needle intervention
    Hakan Kaya
    Department of Obstetrics and Gynecology, Suleyman Demirel University, School of Medicine, Isparta, Turkey
    J Minim Invasive Gynecol 12:355-8. 2005
    ..It seems to preserve the beneficial effects and probably omits unwanted effects (such as adhesion formation) of LOD...
  21. ncbi Childhood tumor risk after treatment with ovulation-stimulating drugs
    Louise A Brinton
    Division of Cancer Epidemiology, National Cancer Institute, Bethesda, Maryland, USA
    Fertil Steril 81:1083-91. 2004
    ..To assess childhood cancer risk among children conceived following the use of ovulation-stimulating drugs...
  22. ncbi Intercycle variability of ovarian reserve tests: results of a prospective randomized study
    J Kwee
    Division of Reproductive Endocrinology and Fertility and the IVF Centre, Department of Obstetrics and Gynaecology, Vrije Universiteit Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Hum Reprod 19:590-5. 2004
    ....
  23. ncbi Aromatase inhibition reduces gonadotrophin dose required for controlled ovarian stimulation in women with unexplained infertility
    M F M Mitwally
    Samuel Lunenfeld Research Institute and Mount Sinai Hospital, Reproductive Sciences Division, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada
    Hum Reprod 18:1588-97. 2003
    ..Previously, we reported the success of aromatase inhibition in inducing ovulation without antiestrogenic effects...
  24. ncbi The effect of obesity on the outcome of infertility management in women with polycystic ovary syndrome
    Majedah Al-Azemi
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Kuwait University, Kuwait
    Arch Gynecol Obstet 270:205-10. 2004
    ..Obesity has become a worldwide epidemic with ever increasing incidence and public health problems in both developing and developed countries...
  25. ncbi A randomized comparison of ovulation induction and hormone profile between the aromatase inhibitor anastrozole and clomiphene citrate in women with infertility
    Hsin Hung Wu
    Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan
    Gynecol Endocrinol 23:76-81. 2007
    ..IN the present study we evaluated and compared the effects of ovulation and hormonal dynamics induced by anastrozole and clomiphene citrate in women with infertility...
  26. ncbi Endometrial thickness cannot predict ongoing pregnancy achievement in cycles stimulated with clomiphene citrate for intrauterine insemination
    E M Kolibianakis
    Centre for Reproductive Medicine, Dutch Speaking Brussels Free University, Brussels, Belgium
    Reprod Biomed Online 8:115-8. 2004
    ..51, 95% CI: 0.44-0.59). In conclusion, endometrial thickness cannot predict ongoing pregnancy achievement in IUI cycles stimulated with clomiphene citrate...
  27. ncbi Alternative approaches in the management of poor response in controlled ovarian hyperstimulation (COH)
    Dimitris Loutradis
    1st Dept Ob Gyn, Athens University Medical School, Alexandria Maternity Hospital, Athens, Greece
    Ann N Y Acad Sci 997:112-9. 2003
    ..More studies with large numbers of patients are needed in order to find those protocols that could provide these couples with an acceptable pregnancy rate...
  28. ncbi High singleton live birth rate following classical ovulation induction in normogonadotrophic anovulatory infertility (WHO 2)
    Marinus J C Eijkemans
    Center for Clinical Decision Sciences, Department of Public Health, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Hum Reprod 18:2357-62. 2003
    ....
  29. pmc The decrease of serum luteinizing hormone level by a gonadotropin-releasing hormone antagonist following the mild IVF stimulation protocol for IVF and its clinical outcome
    Atsushi Yanaihara
    Denentoshi Ladies Clinic Reproductive Center, 2 3 10 5F Aoba ku, Yokohama shi, Kanagawa 227 0062, Japan
    J Assist Reprod Genet 25:115-8. 2008
    ..While performing the mild ovarian stimulation protocol with a GnRH antagonist, the pregnancy rate was compared between the groups, which were divided by the degree that the luteinizing hormone (LH) level decreased...
  30. ncbi Ovulation induction in women with polycystic ovary syndrome: randomized trial of clomiphene citrate versus low-dose recombinant FSH as first line therapy
    Eugenio López
    Department of Obstetrics and Gynecology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
    Reprod Biomed Online 9:382-90. 2004
    ..Thus, further studies, possibly multi-centre, in order to avoid problems with patient recruitment, are warranted to confirm these results...
  31. ncbi [Revisiting the clomifene-gonadotropin protocol in IVF with the use of a GnRH antagonist]
    J C Emperaire
    Centre de FIV Aquitaine Santé, Clinique Jean Villar, 33520 Bruges, France
    Gynecol Obstet Fertil 31:927-31. 2003
    ..To assess the ability of GnRH antagonists to prevent LH surges during superovulation for IVF in classical stimulation protocols with clomiphene and gonadotropins...
  32. ncbi Thorough sonographic oocyte retrieval during in vitro fertilization produces results similar to ovarian wedge resection in patients with clomiphene citrate-resistant polycystic ovarian syndrome
    Emmett F Branigan
    Bellingham IVF and Infertility Center, Bellingham, WA, USA
    Am J Obstet Gynecol 194:1696-700; discussion 1700-1. 2006
    ....
  33. ncbi Hormonal and sonographic assessment of ovarian reserve before and after laparoscopic ovarian drilling in polycystic ovary syndrome
    Mohamed Kandil
    Department of Obstetrics and Gynecology, Faculty of Medicine, Menofyia University, Egypt
    BJOG 112:1427-30. 2005
    ..9 +/- 2.1; P= 0.007 and 11.5 +/- 1.0 vs 10.3 +/- 1.1/mm3; P= 0.001). We concluded that diminished ovarian reserve may occur after bilateral ovarian drilling but not after clomiphene citrate induction of ovulation or unilateral drilling...
  34. ncbi Treatment with gonadotropin-releasing hormone (GnRH) antagonists in women suppressed with GnRH agonist may avoid cycle cancellation in patients at risk for ovarian hyperstimulation syndrome
    Robert L Gustofson
    Walter Reed Army Medical Center, National Naval Medical Center, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Fertil Steril 85:251-4. 2006
    ..5% and 41.0% of pretreatment values (long luteal and microdose flare, respectively) after initiation of ganirelix, and 68.1% of the patients became pregnant...
  35. ncbi Obesity and Clomiphene Challenge Test as predictors of outcome of in vitro fertilization and intracytoplasmic sperm injection
    Esther C A M van Swieten
    Department of Obstetrics and Gynecology, Deventer Ziekenhuis, Deventer, The Netherlands
    Gynecol Obstet Invest 59:220-4. 2005
    ..Obese patients show a tendency to experience more cancellation due to poor response and lower fertilization rates. Obese women should be counseled on their possible poor performance in IVF and IVF/ICSI programs...
  36. ncbi Ovulation induction with tamoxifen and alternate-day gonadotrophin in patients with thin endometrium
    Chia Woei Wang
    Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5 Fu Hsing Street, Kwei Shan, Tao Yuan, Taiwan
    Reprod Biomed Online 17:20-6. 2008
    ..These results suggest that although tamoxifen may not be a first-line treatment in patients with adequate endometrium, it may be a promising alternative for patients with thin endometrium...
  37. ncbi Use of follicle-stimulating hormone test to predict poor response in in vitro fertilization
    Akira Iwase
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Obstet Gynecol 105:645-52. 2005
    ..The purpose of this study was to estimate whether the ovarian reserve test using exogenous follicle-stimulating hormone (FSH) could predict ovarian response in IVF...
  38. ncbi Letrozole induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome may not depend on the period of infertility, the body mass index, or the luteinizing hormone/follicle-stimulating hormone ratio
    Aboubakr Elnashar
    Benha University Hospital, Benha, Egypt
    Fertil Steril 85:511-3. 2006
    ..6% and pregnancy rate of 25%. There was no significant difference between letrozole responders and nonresponders in age, period of infertility, body mass index, waist circumference, LH, FSH, or LH/FSH ratio...
  39. ncbi Comparison of letrozole and clomiphene citrate in women with polycystic ovaries undergoing ovarian stimulation
    V Atay
    Obstetrics and Gynaecology Department, GATA Haydarpasa Training Hospital, Istanbul, Turkey
    J Int Med Res 34:73-6. 2006
    ..In conclusion, letrozole is associated with a higher pregnancy rate than CC in PCO patients and may have a role as a first-line treatment for anovulatory patients with PCOs...
  40. pmc Metformin in the treatment of infertility in polycystic ovarian syndrome: an alternative perspective
    John E Nestler
    Fertil Steril 90:14-6. 2008
    ..Evidence is provided for the use of metformin in selected patients...
  41. ncbi Ovarian reserve
    Maria Elisabetta Coccia
    Department of Gynaecology, Perinatology and Human Reproduction, University of Florence, 50100 Florence, Italy
    Ann N Y Acad Sci 1127:27-30. 2008
    ..But the simultaneous evaluation of a combination of tests could be used as a marker of diminished ovarian reserve and a sensitive predictor of response to ovarian stimulation in patients undergoing in vitro fertilization treatment...
  42. ncbi Are laparoscopic ovarian diathermy and gonadotropin administration the only therapeutic second-steps in clomiphene-citrate resistant women with polycystic ovary syndrome?
    Stefano Palomba
    Hum Reprod 19:2682-3; author reply 2683. 2004
  43. ncbi A new era in ovulation induction
    Hananel Holzer
    Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada
    Fertil Steril 85:277-84. 2006
    ..To evaluate the efficacy of aromatase inhibitors in ovulation induction, superovulation, and IVF...
  44. ncbi Obstetric implications for and identification of women with a normal clomiphene citrate challenge test result who have a poor response to gonadotropins
    Glen E Hofmann
    Bethesda Center for Reproductive Health and Infertility, Bethesda Hospital, Cincinnati, Ohio 45242, USA
    Fertil Steril 82:908-12. 2004
    ..To determine the incidence and obstetric implications and to identify prospectively women with a poor response to hMG with a normal clomiphene citrate challenge test (CCCT) result...
  45. ncbi Insulin-sensitizing agents as primary therapy for patients with polycystic ovarian syndrome
    Sonya Kashyap
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Hum Reprod 19:2474-83. 2004
    ..This paper is a systematic review of metformin versus clomiphene citrate (CC) in women with polycystic ovary syndrome (PCOS)...
  46. ncbi Effect of oral contraceptive pill pretreatment on ongoing pregnancy rates in patients stimulated with GnRH antagonists and recombinant FSH for IVF. A randomized controlled trial
    Efstratios M Kolibianakis
    Unit for Human Reproduction, Aristotle University, GR 54603 Thessaloniki, Greece
    Hum Reprod 21:352-7. 2006
    ..The objective of this randomized controlled trial was to assess the effect of oral contraceptive pill (OCP) pretreatment on the probability of ongoing pregnancy in patients treated with a GnRH antagonist for IVF...
  47. ncbi The use of gonadotropin-releasing hormone (GnRH) agonist to induce oocyte maturation after cotreatment with GnRH antagonist in high-risk patients undergoing in vitro fertilization prevents the risk of ovarian hyperstimulation syndrome: a prospective rando
    Lawrence Engmann
    Center for Advanced Reproductive Services, Department of Obstetrics and Gynecology, Dowling South Building, University of Connecticut Health Center, Farmington, Connecticut 06030 6224, USA
    Fertil Steril 89:84-91. 2008
    ....
  48. ncbi Predictive power of clomiphene citrate challenge test for failure of in vitro fertilization treatment
    György Csemiczky
    Reproductive Medical Center, Department of Women and Child Health, Division of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden
    Acta Obstet Gynecol Scand 81:954-61. 2002
    ..To evaluate the impact of ovarian reserve on the outcome of in vitro fertilization (IVF) treatment in 140 women, in a total of 279 treatment cycles...
  49. ncbi Use of cetrorelix in combination with clomiphene citrate and gonadotrophins: a suitable approach to 'friendly IVF'?
    J B Engel
    Division of Reproductive Medicine and Gynecologic Endocrinology, Department of Gynecology and Obstetrics, University Clinic, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Hum Reprod 17:2022-6. 2002
    ..With the recently introduced GnRH antagonists, soft stimulation protocols on the basis of clomiphene pretreatment should be possible as the pituitary remains fully sensitive at the beginning of the cycle...
  50. ncbi Factors associated with pregnancy or miscarriage after clomiphene therapy in WHO group II anovulatory women
    Stella R Milsom
    Department of Reproductive Medicine, National Women s Hospital, University of Auckland, New Zealand
    Aust N Z J Obstet Gynaecol 42:170-5. 2002
    ....
  51. ncbi Elevated serum progesterone-to-estradiol ratio during gonadotropin stimulation for intrauterine insemination or in vitro fertilization is not associated with diminished ovarian reserve
    Glen E Hofmann
    Department of Obstetrics and Gynecology, Bethesda Center for Reproductive Health and Fertility, Bethesda Hospital, Cincinnati, Ohio 45206, USA
    Fertil Steril 78:47-50. 2002
    ..To determine whether an elevated serum P:E2 ratio on the day of hCG administration during gonadotropin stimulation for intrauterine insemination (IUI) or IVF is associated with diminished ovarian reserve...
  52. ncbi Anastrozole or letrozole for ovulation induction in clomiphene-resistant women with polycystic ovarian syndrome: a prospective randomized trial
    Ahmed Badawy
    Department of Obstetrics and Gynecology, Mansoura University, Mansoura, Egypt
    Fertil Steril 89:1209-12. 2008
    ..To compare the effects of letrozole (2.5 mg) and anastrozole (1 mg) meant for ovulation induction in clomiphene (CC)-resistant women with PCOS...
  53. ncbi New advances in ovulation induction
    Souzan Kafy
    Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada
    Curr Opin Obstet Gynecol 19:248-52. 2007
    ..To review recent advances in ovulation induction...
  54. ncbi Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome
    Michael J Heard
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Baylor College of Medicine, Houston, Texas 77030, USA
    Fertil Steril 77:669-73. 2002
    ..To assess pregnancy outcome in anovulatory infertility patients diagnosed with polycystic ovary syndrome (PCOS) who were treated with metformin...
  55. ncbi Management of poor responders: can outcomes be improved with a novel gonadotropin-releasing hormone antagonist/letrozole protocol?
    William B Schoolcraft
    Colorado Center for Reproductive Medicine, Englewood, Colorado, USA
    Fertil Steril 89:151-6. 2008
    ..To compare the efficacy of a microdose GnRH agonist flare (ML) with a GnRH antagonist/letrozole (AL) protocol before IVF-ET in poor responders...
  56. pmc Ovarian volume and antral follicle count for the prediction of low and hyper responders with in vitro fertilization
    Janet Kwee
    Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Reprod Biol Endocrinol 5:9. 2007
    ....
  57. ncbi A nomogram to predict the probability of live birth after clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility
    Babak Imani
    Division of Reproductive Medicine, Rotterdam, The Netherlands
    Fertil Steril 77:91-7. 2002
    ..To establish whether initial screening characteristics of normogonadotropic anovulatory infertile women can aid in predicting live birth after induction of ovulation with clomiphene citrate (CC)...
  58. ncbi Metformin improves ovulation and pregnancy rates in patients with polycystic ovary syndrome
    C Batukan
    , Kantonspital, Basel
    Arch Gynecol Obstet 265:124-7. 2001
    ..The high pregnancy rate of our study population is consistent with the hypothesis that insulin resistance plays an important role in the pathogenesis of anovulation in patients with PCOS...
  59. ncbi Useful predictors of ovarian stimulation response in women undergoing in vitro fertilization
    J G van der Stege
    Department of Obstetrics and Gynaecology, Academisch Ziekenhuis Groningen, The Netherlands
    Gynecol Obstet Invest 52:43-6. 2001
    ..The basal estradiol level did not contribute to further discrimination between groups. We conclude that basal FSH level on cycle day 3 is a useful prognosticator of ovarian stimulation response...
  60. ncbi Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction and achievement of pregnancy in 154 women with polycystic ovary syndrome
    Nathalie Neveu
    PROCREA Cliniques, Mont Royal, Quebec, Canada
    Fertil Steril 87:113-20. 2007
    ....
  61. ncbi Treating the polycystic ovary syndrome the old-fashioned way
    David S Guzick
    N Engl J Med 356:622-4. 2007
  62. ncbi Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review
    Thomas I Siebert
    Reproductive Biology Unit, Department of Obstetrics and Gynaecology, Stellenbosch University and Tygerberg Hospital, Tygerberg, South Africa
    Fertil Steril 86:1432-7. 2006
    ..The aim of this literature search is to establish if metformin is efficacious when given to clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS) patients...
  63. ncbi Sequential treatment of metformin and clomiphene citrate in clomiphene-resistant women with polycystic ovary syndrome: a randomized, controlled trial
    Susan Shanti George
    Reproductive Medicine Unit, Department of Clinical Biochemistry, Department of Biostatistics and Department of Endocrinology, Christian Medical College, Vellore, Tamil Nadu, India
    Hum Reprod 18:299-304. 2003
    ..Recognition of the importance of insulin resistance in clomiphene-resistant women with polycystic ovary syndrome (PCOS) has led to the use of insulin sensitizers...
  64. ncbi Comparison of the efficacy of the aromatase inhibitor letrozole and clomiphene citrate as adjuvants to recombinant follicle-stimulating hormone in controlled ovarian hyperstimulation: a prospective, randomized, blinded clinical trial
    Gerardo Barroso
    Assisted Reproductive Division, Instituto Nacional de Perinatologia, Mexico City, Mexico
    Fertil Steril 86:1428-31. 2006
    ..To study the efficacy of the aromatase inhibitor letrozole as adjuvant to recombinant FSH (rFSH) in controlled ovarian hyperstimulation (COH)...
  65. ncbi The clomiphene citrate challenge test for the prediction of poor ovarian response and nonpregnancy in patients undergoing in vitro fertilization: a systematic review
    Dave J Hendriks
    Department of Reproductive Medicine, Division of Obstetrics, Neonatology and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands
    Fertil Steril 86:807-18. 2006
    ..To systematically review the value of the clomiphene citrate challenge test (CCCT) in the prediction of poor ovarian response and pregnancy in IVF...
  66. ncbi The impact of LH serum concentration on the clinical outcome of IVF cycles in patients receiving two regimens of clomiphene citrate/gonadotrophin/0.25 mg cetrorelix
    Asimina Tavaniotou
    AZ VUB, Centre for Reproductive Medicine, Dutch speaking Free University of Brussels, Laarbeeklaan 101, 1090 Brussels, Belgium
    Reprod Biomed Online 6:421-6. 2003
    ..25 cycles. Cetrorelix 0.25 mg/day was associated with a high incidence of premature LH surges and premature LH surges were associated with an adverse cycle outcome...
  67. ncbi A randomized clinical trial of treatment of clomiphene citrate-resistant anovulation with the use of oral contraceptive pill suppression and repeat clomiphene citrate treatment
    Emmett F Branigan
    Bellingham In Vitro Fertilization and Infertility Center, WA 98225, USA
    Am J Obstet Gynecol 188:1424-8; discussion 1429-30. 2003
    ..The purpose of this study was to evaluate the effectiveness and endocrine response of oral contraceptive ovarian suppression followed by clomiphene citrate in patients who previously were clomiphene citrate resistant...
  68. ncbi Recombinant FSH in alternative doses or versus urinary gonadotrophins for ovulation induction in subfertility associated with polycystic ovary syndrome: a systematic review based on a Cochrane review
    M van Wely
    Center for Reproductive Medicine, Department of Obstetrics and Gynecology H4 205, Academic Medical Center, University of Amsterdam, PO Box 22700, The Netherlands
    Hum Reprod 18:1143-9. 2003
    ..More randomized clinical trials with sufficient power are necessary to estimate the difference, if one exists, between rFSH and uFSH and between different dose regimens of rFSH...
  69. ncbi Follicular growth, endometrial thickness, and serum estradiol levels in spontaneous and clomiphene citrate-induced cycles
    S Haritha
    Department of Obstetrics and Gynecology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India
    Int J Gynaecol Obstet 81:287-92. 2003
    ..To evaluate follicular growth, endometrial thickness, and serum estradiol levels in spontaneous cycles and cycles induced by clomiphene citrate (CC)...
  70. ncbi Ovarian stimulation by clomiphene citrate and hMG in combination with cetrorelix acetate for ICSI cycles
    Jiann Loung Hwang
    Department of Obstetrics and Gynecology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Hum Reprod 18:45-9. 2003
    ..The introduction of GnRH antagonists such as cetrorelix acetate has made possible the simplification of ovarian stimulation. However, the most effective protocol for their administration has not yet been clearly defined...
  71. ncbi Adding human menopausal gonadotrophin to antagonist protocols - is there a benefit?
    Meredith Martin-Johnston
    Illinois Masonic Medical Centre, 836 West Wellington Avenue, Chicago, IL 60657, USA
    Reprod Biomed Online 15:161-8. 2007
    ..In conclusion, irrespective of age, using a treatment regimen consisting of a combination of HMG plus r-FSH was not beneficial compared with r-FSH alone in patients using a GnRH antagonist protocol...
  72. ncbi [Ovulation induction therapy and systemic lupus erythematosus]
    Du Le Thi Huong
    Service de Medecine Interne, Groupe Hospitalier Pitie Salpetriere, 47 83, Boulevard de l Hopital, 75651 Paris Cedex 13
    Ann Med Interne (Paris) 154:45-50. 2003
    ....
  73. ncbi Impact of metformin therapy on ovarian stimulation and outcome in 'coasted' patients with polycystic ovary syndrome undergoing in-vitro fertilization
    L A Stadtmauer
    North Carrolina Centre for Reproductive Medicine, Cary, NC, USA
    Reprod Biomed Online 5:112-6. 2002
    ..05). Therefore, metformin use appears beneficial in improving IVF outcomes in clomiphene citrate-resistant PCOS patients...
  74. ncbi Comparison of pregnancy rates in dromedary camels (Camelus dromedarius) after deep intra-uterine versus cervical insemination
    J A Skidmore
    Camel Reproduction Centre, P O Box 11808, Dubai, United Arab Emirates
    Theriogenology 66:292-6. 2006
    ....
  75. pmc Ovarian reserve evaluation: state of the art
    Bruno Ramalho de Carvalho
    Sector of Human Reproduction, Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    J Assist Reprod Genet 25:311-22. 2008
    ..Revise role of hormonal basal and dynamic tests, as well as ultrasonographic measures as ovarian reserve markers, in order to provide better counseling to subfertile couples...
  76. ncbi [Idiopathic central precocious puberty in girls in Bahia, Brazil]
    Ana Luísa Aguiar
    Departamento de Pediatria, Faculdade de Medicina, Universidade Federal da Bahia, Centro de Diabetes e Endocrinologia, Salvador, BA
    Arq Bras Endocrinol Metabol 49:536-41. 2005
    ..Although the therapeutic effects of GnRH analogues (GnRHa) in central precocious puberty (CPP) have been established, clinical aspects may vary according to racial groups...
  77. ncbi Hemoperitoneum from ruptured cyst in a hyperstimulated ovary: a sonographic mimic of ovarian hyperstimulation syndrome
    Gowthaman Gunabushanam
    Department of Radiodiagnosis, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    J Clin Ultrasound 35:281-3. 2007
    ..Radiologists must be familiar with the imaging features of this condition to avoid misdiagnosing it as OHSS, because this could potentially delay urgently required surgery...
  78. ncbi Treatment of infertility in the polycystic ovary syndrome
    Tarekegn Geberhiwot
    N Engl J Med 356:2000; author reply 1999-2001. 2007
  79. ncbi Gonadotropin-releasing hormone agonists for prevention of chemotherapy-induced ovarian damage: prospective randomized study
    Ahmed Badawy
    Department of Obstetrics and Gynecology, Mansura University, Mansoura, Egypt
    Fertil Steril 91:694-7. 2009
    ..To determine whether GnRHa administration before and during combination chemotherapy for breast cancer could preserve posttreatment ovarian function in young women or not...
  80. pmc Outcome of frozen-thawed blastocysts derived from gonadotropin releasing hormone agonist or antagonist cycles
    Robert Medved
    Reproductive Unit, Department of Obstetrics and Gynecology, University Medical Centre, Ginekoloska klinika, Slajmerjeva 3, SI 1000, Ljubljana, Slovenia
    J Assist Reprod Genet 23:275-9. 2006
    ..The aim of this retrospective study was to compare the outcome of frozen-thawed blastocysts derived from the cycles using controlled ovarian stimulation with GnRH agonists vs. GnRH antagonists...
  81. ncbi Reversible reproductive control in harbour seals (Phoca vitulina) with a gonadotropin-releasing hormone agonist
    U Siebert
    Research and Technology Center Westcoast, University of Kiel, Werftstrasse 6, 25761 Busum, Germany
    Theriogenology 67:605-8. 2007
    ..This study shows that the gonadotropin-releasing hormone agonist, burserelin acetate, can be used for reversible reproductive control in harbour seals without observed side effects or detrimental behavioural changes...
  82. pmc Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial
    Peter G McGovern
    Department of Obstetrics, UMDNJ, New Jersey Medical School, Newark, New Jersey 07101 1709, USA
    Fertil Steril 90:1283-6. 2008
    ....
  83. ncbi Gonadotrophin-releasing hormone and magnetic-resonance-guided ultrasound surgery for uterine leiomyomata
    O C Smart
    Academic Department of Obstetrics and Gynaecology, Department of Radiology, Imperial College London at St Mary s Hospital, London, United Kingdom
    Obstet Gynecol 108:49-54. 2006
    ....
  84. ncbi Comparison of protocols to synchronize estrus and ovulation in estrous-cycling and prepubertal beef heifers
    N R Leitman
    Division of Animal Science, S132 ASRC, University of Missouri, Columbia 65211, USA
    J Anim Sci 86:1808-18. 2008
    ..01) compared with T2. In summary, CIDR Select improved (P < 0.01) the synchrony of estrus and ovulation compared with Select Synch + CIDR...
  85. ncbi Comparisons of different dosages of gonadotropin-releasing hormone (GnRH) antagonist, short-acting form and single, half-dose, long-acting form of GnRH agonist during controlled ovarian hyperstimulation and in vitro fertilization
    Yao Yuan Hsieh
    Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan
    Taiwan J Obstet Gynecol 47:66-74. 2008
    ..We aimed to determine the minimum effective daily dose of GnRH antagonist in women undergoing COH. We also compared the efficiency of a GnRH antagonist and a GnRH agonist...
  86. ncbi Arias-Stella reaction in a cervicovaginal smear of a woman undergoing infertility treatment: a case report
    Millie Lui
    Department of Pathology, University Health Network, Department of Pathobiology and Laboratory Medicine, University of Toronto, Toronto, Ontario, Canada
    Diagn Cytopathol 32:94-6. 2005
    ..It is of paramount importance to recognize this phenomenon in cervical Pap smears, especially in women receiving ovulation-inducing agents and exogenous hormonal treatment to avoid this potential cytological pitfall...
  87. pmc Evaluating the equivalence of clomiphene citrate with and without metformin in ovulation induction in PCOS patients
    T I Siebert
    Reproductive Biology Unit, Department of Obstetrics and Gynaecology, Stellenbosch University and Tygerberg Academic Hospital, Tygerberg, South Africa
    J Assist Reprod Genet 26:165-71. 2009
    ..To evaluate the benefit of Metformin added to Clomiphene Citrate in a primary ovulation induction protocol in PCOS patients...
  88. ncbi Gonadotropin-releasing hormone agonist to induce final oocyte maturation prevents the development of ovarian hyperstimulation syndrome in high-risk patients and leads to improved clinical outcomes compared with coasting
    Andrea J DiLuigi
    The Center for Advanced Reproductive Services, Division of Reproductive Endocrinology and Infertility, University of Connecticut Health Center, Farmington, Connecticut 06030 6224, USA
    Fertil Steril 94:1111-4. 2010
    ..3) P<0.001, more normally fertilized oocytes (15.0+/-7.8 vs. 10.3+/-6.3) P=0.01, and higher clinical and ongoing pregnancy rates than the coasting group (52.5% vs. 27.2%; 49.2% vs. 24.2%, P=0.02 for both comparisons, respectively)...
  89. pmc Metformin does not enhance ovulation induction in clomiphene resistant polycystic ovary syndrome in clinical practice
    N D C Sturrock
    Department of Endocrinology, Nottingham City Hospital NHS Trust, Hucknall Road, UK
    Br J Clin Pharmacol 53:469-73. 2002
    ..To determine whether metformin pretreatment has beneficial effects in clomiphene resistant infertile women with polycystic ovary syndrome (PCOS) in an infertility clinic...
  90. ncbi Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial
    Hatem Abu Hashim
    Department of Obstetrics, Mansoura University, Mansoura, Egypt
    Fertil Steril 94:1405-9. 2010
    ..To compare the effect of letrozole with combined metformin and clomiphene citrate (CC) for ovulation induction in CC-resistant women with polycystic ovary syndrome (PCOS)...
  91. ncbi Endometriosis, in vitro fertilisation and the risk of gynaecological malignancies, including ovarian and breast cancer
    Nikos F Vlahos
    Department of Obstetrics and Gynecology, Aretaieio Hospital, University of Athens, 76 Vas Sofias Av, 11527, Athens, Greece
    Best Pract Res Clin Obstet Gynaecol 24:39-50. 2010
    ..More studies with the appropriate statistical power and follow-up time are required to evaluate accurately the long-term effects of these drugs and procedures...
  92. ncbi Progesterone therapy versus follicle maturing drugs--possible opposite effects on embryo implantation
    J H Check
    Clin Exp Obstet Gynecol 29:5-10. 2002
    ..In some cases the use of follicle maturing drugs creates a hostile uterine environment possibly related to premature trophoblast invasion...
  93. ncbi [Biophysical characteristics of cervical mucus after stimulation of ovulation by clomiphene citrate and HMG]
    A Mroczkowski

    Ginekol Pol 72:1329-33. 2001
    ..It was the highest during cycles were CC and HMG were used, although they did not reflect the risk of hyperstimulation. Authors discuss the importance of their findings in cases when techniques of ART can not be applied...
  94. ncbi Comparison of stimulation with clomiphene citrate in combination with recombinant follicle-stimulating hormone and recombinant luteinizing hormone to stimulation with a gonadotropin-releasing hormone agonist protocol: a prospective, randomized study
    Monika Weigert
    Institut für Sterilitätsbetreuung, Vienna, Austria
    Fertil Steril 78:34-9. 2002
    ..To compare IVF-ET outcome with a new stimulation protocol using clomiphene citrate (CC) with recombinant FSH and LH to stimulation with the standard long GnRH-a protocol...
  95. ncbi Factors affecting the survival of sheep embryos after transfer within a MOET program
    F Bari
    Institute of Rural Studies, University of Wales Aberystwyth, Llanbadarn Campus, Aberystwyth, Ceredigion SY23 3AL, UK
    Theriogenology 59:1265-75. 2003
    ..These results confirm that both embryonic and recipient factors can play an important role in the success of a MOET program in sheep...
  96. ncbi Use of dexamethasone and clomiphene citrate in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome and normal dehydroepiandrosterone sulfate levels: a prospective, double-blind, placebo-controlled trial
    Mohammad Ebrahim Parsanezhad
    Division of Infertility, Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
    Fertil Steril 78:1001-4. 2002
    ..To evaluate the effects of short-course administration of dexamethasone (DEX) combined with clomiphene citrate (CC) in CC-resistant patients with polycystic ovary syndrome (PCOS) and normal DHEAS levels...
  97. ncbi Ovulation induction in perspective
    Roy Homburg
    Lis Maternity Hospital, Tel Aviv Sourasky Medical Centre, Israel
    Hum Reprod Update 8:449-62. 2002
    ....
  98. ncbi An economic evaluation of laparoscopic ovarian diathermy versus gonadotrophin therapy for women with clomiphene citrate resistant polycystic ovary syndrome
    Cynthia M Farquhar
    Department of Obstetrics and Gynaecology, University of Auckland, New Zealand
    Hum Reprod 19:1110-5. 2004
    ....
  99. ncbi Reproduction after breast cancer
    Stefanos Zervoudis
    University of Medicine and Pharmacy, C Davila, Bucharest, Romania
    Best Pract Res Clin Obstet Gynaecol 24:81-6. 2010
    ....
  100. ncbi Development of a sensitive enzyme immunoassay for anti-Müllerian hormone and the evaluation of potential clinical applications in males and females
    A Al-Qahtani
    School of Biological and Molecular Sciences, Oxford Brookes University, Headington, Oxford, UK
    Clin Endocrinol (Oxf) 63:267-73. 2005
    ..The objectives of this study were to develop a sensitive and specific assay for AMH and to evaluate the potential application of the assay. This assay will be then available to our collaborators in the UK and overseas...
  101. ncbi [Influence of GnRH analogue on the intensification of endometriosis symptoms and infertility treatment]
    Violetta Skrzypulec
    Z Katedry Zdrowia Kobiety Slaskiej Akademii Medycznej w Katowicach
    Wiad Lek 57:301-4. 2004
    ..Pelvic pain evaluation showed that its level was lower in the investigated group (p > 0.05). It was found that 11 women (investigated group) and 5 women (control group) got pregnant after the period of 12-week treatment...

Research Grants26

  1. INSULIN RESISTANCE IN PCOS--SEQUELAE AND TREATMENT
    RICHARD LEGRO; Fiscal Year: 2005
    ..Improving insulin action through diet and exercise, with and without weight loss, will result in lowered circulating insulin levels, lowered androgens and increased ovulatory frequency rate in PCOS women. ..
  2. Effect of Continuous vs. Sequential Oral Contraception
    RICHARD LEGRO; Fiscal Year: 2004
    ..Therefore, the risks and benefits of a CCOCP regimen are an important women's health issue that warrant investigation. ..
  3. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2003
    ....
  4. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2010
    ..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
  5. Characterizing Mammalian Embryonic polyA Binding Protein
    Emre Seli; Fiscal Year: 2008
    ....
  6. GONADOTROPIN-RELEASING HORMONE ACTION
    P Michael Conn; Fiscal Year: 2008
    ..The specific aims of this study will advance both our basic understanding and will identify new sites and approaches potentially amenable to therapeutic intervention. [unreadable] [unreadable]..
  7. Steroid Hormone Genes and Ovarian Cancer Risk
    Mary Anne Rossing; Fiscal Year: 2010
    ..The proposed study, by expanding our knowledge of the role of progestogens, estrogens, and androgens in the development of ovarian cancer, will inform efforts to develop effective strategies to prevent this disease. ..
  8. Progesterone Modulation of Pulsatile GnRH Secretion
    CHRISTOPHER MCCARTNEY; Fiscal Year: 2007
    ..McCartney's development into an independent patient-oriented investigator in the field of reproductive endocrinology. [unreadable] [unreadable]..
  9. HOX GENE EXPRESSION IN HUMAN ENDOMETRIUM
    Hugh Taylor; Fiscal Year: 2007
    ..These studies will further characterize the molecular mechanisms by which HOX expression is related to normal and pathologic endometrial development. ..
  10. NEUROBIOLOGICAL EFFECT OF LONG-TERM ESTROGEN REPLACEMENT
    Yolanda Smith; Fiscal Year: 2006
    ..Comparison between groups will offer a greater understanding of the effect of hormone therapies on brain neurochemistry and cognition. ..
  11. EPIDEMIOLOGY OF SMOKING CESSATION--GENETIC INFLUENCES
    MARY ROSSING; Fiscal Year: 2002
    ..In the future, such knowledge may allow the identification of subgroups of individuals who are most likely to benefit from particular pharmacologic interventions. ..
  12. Epidemiology of Ovarian Cancer:New Hypotheses
    MARY ROSSING; Fiscal Year: 2006
    ..abstract_text> ..
  13. Neurobiology of the Menopausal Transition
    Yolanda R Smith; Fiscal Year: 2010
    ..A better understanding of the areas and sequence of brain processing changes will allow the health community to plan interventions which most effectively preserve cognitive and emotional health for women. ..
  14. Use of Antidepressants and Risk of Breast Cancer
    MARY ROSSING; Fiscal Year: 2003
    ..g., SSRIs or tricyclics), and individual drugs such as fluoxetine and paroxetine. Use of the pharmacy database will provide unbiased and complete exposure data relative to previous studies based on self-reported drug use. ..
  15. Metabolic Syndrome in PCOS: Precursors and Interventions
    Andrea Dunaif; Fiscal Year: 2010
    ..The proposed research has substantial scientific as well as public health implications because it promises to identify precursors of and novel therapeutic targets for metabolic abnormalities in PCOS. ..
  16. Genome-Wide Association Scan of Polycystic Ovary Syndrome Phenotypes
    Andrea Dunaif; Fiscal Year: 2010
    ..This information should lead to more effective and specific treatments as well as to disease prediction and prevention. ..
  17. Cell Cycle Inhibitors in Alzheimer Disease
    Mark Smith; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  18. U of R Human Subjects Collaborative Research Enhancement
    David Guzick; Fiscal Year: 2003
    ..This can be viewed as the first steps in the development of an interoperative clinical research network as envisioned within the NIH Strategic Plan. ..
  19. Antiapoptotic Activity of Alzheimer Abeta
    Craig Atwood; Fiscal Year: 2003
    ..We also will test whether oxidative stress induces neurons to re-enter the cell cycle as a mechanism leading to cell death. ..
  20. EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT PROGRAM
    David Guzick; Fiscal Year: 2003
    ..Since much of the current space will continue to house vision science, this C06 award will create a substantial net increase in vision-research facilities and capabilities. ..
  21. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    PETER MCGOVERN; Fiscal Year: 2004
    ..We will then test the hypothesis that this novel protocol, by preventing the hypersecretion of luteal products in gonadotropin-induced pregnancies, will result in safer infertility therapy. ..
  22. Human Endometrial Nitric Oxide: Regulation and Function
    Omid Khorram; Fiscal Year: 2003
    ..This pilot study should shed light on regulation and function of human endometrial NO pathway, an uninvestigated area of research with profound clinical significance. ..
  23. Amyloid-beta: The Alternate Hypothesis
    Mark Smith; Fiscal Year: 2007
    ..Completion of the proposed studies will help determine the role of Aft and, more importantly, guide future therapeutic targets. [unreadable] [unreadable]..
  24. Glucocorticoids and Programming of the Hypertensive Vascular Phenotype
    Omid Khorram; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  25. Treatment of Endometriosis-Associated Pelvic Pain
    David Guzick; Fiscal Year: 2007
    ..In addition, a cost-effectiveness analysis will be performed by calculating the cost per unit reduction in pain score for each treatment. ..