oral contraceptives

Summary

Summary: Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are generally estrogen or progesterone or both.

Top Publications

  1. doi Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23,257 women with ovarian cancer and 87,303 controls
    V Beral
    Cancer Epidemiology Unit, Oxford, UK
    Lancet 371:303-14. 2008
  2. doi GnRH-analogues and oral contraceptives for fertility preservation in women during chemotherapy
    Zeev Blumenfeld
    Reproductive Endocrinology and Infertility Section, Department of Obstetrics and Gynaecology, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Hum Reprod Update 14:543-52. 2008
  3. ncbi Anastrazole and oral contraceptives: a novel treatment for endometriosis
    Lisa L Amsterdam
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Fertil Steril 84:300-4. 2005
  4. doi Pregnancy outcome after exposure to oral contraceptives during the periconceptional period
    H K Ahn
    The Korean Motherisk Program, Cheil Hospital and Women s Health care Center, Kwandong University College of Medicine, Seoul, Korea
    Hum Exp Toxicol 27:307-13. 2008
  5. ncbi Oral contraceptives and the risk of breast cancer
    Polly A Marchbanks
    Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 346:2025-32. 2002
  6. ncbi Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis
    Gabriela F Meresman
    Instituto de Biología y Medicina Experimental IBYME, Buenos Aires, Argentina
    Fertil Steril 77:1141-7. 2002
  7. pmc Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers
    S Hagg
    Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Br J Clin Pharmacol 51:169-73. 2001
  8. ncbi Relation of contraceptive and reproductive history to ovarian cancer risk in carriers and noncarriers of BRCA1 gene mutations
    V McGuire
    Department of Health Research and Policy and Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Am J Epidemiol 160:613-8. 2004
  9. ncbi Selective exposure reporting and Medline indexing limited the search sensitivity for observational studies of the adverse effects of oral contraceptives
    Susan Wieland
    Department of Community Health, Center for Gerontology and Health Care Research, Brown University, Providence, RI 02912, USA
    J Clin Epidemiol 58:560-7. 2005
  10. doi Oral contraceptives and androgenicity: influences on visuospatial task performance in younger individuals
    Whitney Wharton
    Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
    Exp Clin Psychopharmacol 16:156-64. 2008

Detail Information

Publications282 found, 100 shown here

  1. doi Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23,257 women with ovarian cancer and 87,303 controls
    V Beral
    Cancer Epidemiology Unit, Oxford, UK
    Lancet 371:303-14. 2008
    b>Oral contraceptives were introduced almost 50 years ago, and over 100 million women currently use them...
  2. doi GnRH-analogues and oral contraceptives for fertility preservation in women during chemotherapy
    Zeev Blumenfeld
    Reproductive Endocrinology and Infertility Section, Department of Obstetrics and Gynaecology, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Hum Reprod Update 14:543-52. 2008
    ..Meanwhile, non-invasive techniques have attempted to minimize the gonadotoxic effect of chemotherapy, by using gonadotrophin-releasing hormone-analogues (GnRH-a) or oral contraceptives (OC).
  3. ncbi Anastrazole and oral contraceptives: a novel treatment for endometriosis
    Lisa L Amsterdam
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Fertil Steril 84:300-4. 2005
    ..To establish the use of aromatase inhibitors as a therapeutic option for endometriosis...
  4. doi Pregnancy outcome after exposure to oral contraceptives during the periconceptional period
    H K Ahn
    The Korean Motherisk Program, Cheil Hospital and Women s Health care Center, Kwandong University College of Medicine, Seoul, Korea
    Hum Exp Toxicol 27:307-13. 2008
    To evaluate whether periconceptional exposure to oral contraceptives (OCs) increased adverse pregnancy outcomes, 136 pregnant women taking OCs within the periconceptional period were identified at the Korean Motherisk Program...
  5. ncbi Oral contraceptives and the risk of breast cancer
    Polly A Marchbanks
    Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 346:2025-32. 2002
    ..We conducted a population-based, case-control study to determine the risk of breast cancer among former and current users of oral contraceptives.
  6. ncbi Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis
    Gabriela F Meresman
    Instituto de Biología y Medicina Experimental IBYME, Buenos Aires, Argentina
    Fertil Steril 77:1141-7. 2002
    To evaluate the effects of administering combination oral contraceptives (COCs) to patients with endometriosis on the regulation of cell growth in the eutopic endometrium.
  7. pmc Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers
    S Hagg
    Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Br J Clin Pharmacol 51:169-73. 2001
    The study was carried out in order to assess the effects of gender and the use of oral contraceptives (OCs) on CYP2D6 and CYP2C19 activities in healthy volunteers.
  8. ncbi Relation of contraceptive and reproductive history to ovarian cancer risk in carriers and noncarriers of BRCA1 gene mutations
    V McGuire
    Department of Health Research and Policy and Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Am J Epidemiol 160:613-8. 2004
    ..In both carriers and noncarriers, reduced risk was associated with ever use of oral contraceptives (odds ratio = 0.54 (95% confidence interval (CI): 0.26, 1.13) for carriers and 0.55 (95% CI: 0.41, 0...
  9. ncbi Selective exposure reporting and Medline indexing limited the search sensitivity for observational studies of the adverse effects of oral contraceptives
    Susan Wieland
    Department of Community Health, Center for Gerontology and Health Care Research, Brown University, Providence, RI 02912, USA
    J Clin Epidemiol 58:560-7. 2005
    To explore development of possible approaches leading to a sensitive and precise Medline search to identify observational studies of the association between oral contraceptives and breast cancer, an adverse event.
  10. doi Oral contraceptives and androgenicity: influences on visuospatial task performance in younger individuals
    Whitney Wharton
    Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
    Exp Clin Psychopharmacol 16:156-64. 2008
    The current study investigated whether the androgenic activity of oral contraceptives (OC) mediates performance on sexually dimorphic cognitive tasks in 155 younger individuals...
  11. ncbi The Coraliance study: non-compliant behavior. Results after a 6-month follow-up of patients on oral contraceptives
    E Aubeny
    Eur J Contracept Reprod Health Care 9:267-77. 2004
    ..In those women who changed from a continuous cycle to an interrupted type of cycle, or vice versa, the study also aimed to evaluate the impact of this change on the pattern of omission of pills...
  12. doi The risk of oral contraceptives in the etiology of inflammatory bowel disease: a meta-analysis
    Julie A Cornish
    Department of Biosurgery and Surgical Technology, St Mary s Hospital, Imperial College, London, United Kingdom
    Am J Gastroenterol 103:2394-400. 2008
    ..The aim of this study was to provide a quantification of the risk of oral contraceptive pill (OCP) use in the etiology of inflammatory bowel disease...
  13. doi Estrogens, oral contraceptives and hormonal replacement therapy increase the incidence of cutaneous melanoma: a population-based case-control study
    E R Koomen
    Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, The Netherlands
    Ann Oncol 20:358-64. 2009
    ..Multiple studies showed conflicting results on the association between oral contraceptive (OC) use and the development of cutaneous melanoma (CM). We investigated the association between estrogen use and CM incidence...
  14. ncbi Oral contraceptives and increased headache prevalence: the Head-HUNT Study
    K Aegidius
    Department of Neuroscience, Norwegian National Headache Centre, St Olav s University Hospital, Trondheim, Norway
    Neurology 66:349-53. 2006
    To examine the prevalence of headache and migraine among women using oral contraceptives (OCs) in a large, cross-sectional population-based study.
  15. ncbi Risk of stroke in women exposed to low-dose oral contraceptives: a critical evaluation of the evidence
    Wee Shian Chan
    Departments of Medicine, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Arch Intern Med 164:741-7. 2004
    ....
  16. ncbi Treating acne with oral contraceptives: use of lower doses
    Johannes Huber
    Division of Gynecology and Infertility Treatment, Department of Obstetrics and Gynecology, Medical University Vienna, A 1090 Vienna, Austria
    Contraception 73:23-9. 2006
    b>Oral contraceptives (OCs) have been shown to effectively treat acne...
  17. ncbi To what extent do oral contraceptives influence mood and affect?
    Kirsten A Oinonen
    Department of Psychology, Lakehead University, Thunder Bay, Ont, Canada P7B 5E1
    J Affect Disord 70:229-40. 2002
    Studies examining the effects of oral contraceptives (OCs) on mood, affect, and affect variability are reviewed.
  18. ncbi Oral contraceptives, reproductive factors, and risk of colorectal cancer among women in a prospective cohort study
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 165:794-801. 2007
    ..09). No significant association was observed between reproductive factors and colorectal cancer risk. These findings provide some support for a potential role of OCs in reducing risk of colorectal cancer...
  19. ncbi Effect of four different oral contraceptives on various sex hormones and serum-binding globulins
    I Wiegratz
    Department of Obstetrics and Gynecology, J W Geothe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Contraception 67:25-32. 2003
    In a double-blind, controlled, randomized, four-arm, bicentric clinical study, the effect of four oral contraceptives (OCs) on various hormone parameters and serum-binding globulins was investigated...
  20. ncbi Oral contraceptives and breast cancer risk in Taiwan, a country of low incidence of breast cancer and low use of oral contraceptives
    W C Chie
    School of Public Health, College of Public Health, National Taiwan University, Taipei
    Int J Cancer 77:219-23. 1998
    ..Our results support the notion that OC use in early life for younger women and in early calendar years increase breast cancer risk...
  21. ncbi Primary dysmenorrhea in adolescent girls and treatment with oral contraceptives
    A R Davis
    Department of Obstetrics and Gynecology, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    J Pediatr Adolesc Gynecol 14:3-8. 2001
    ..Combined oral contraceptives (COC) are an accepted treatment for dysmenorrhea in nonadolescent women...
  22. doi Oral contraceptives and individual variability of circulating levels of ethinyl estradiol and progestins
    Joseph W Goldzieher
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 78212, USA
    Contraception 78:4-9. 2008
  23. ncbi Thrombophilic abnormalities, oral contraceptives, and risk of cerebral vein thrombosis: a meta-analysis
    Francesco Dentali
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Blood 107:2766-73. 2006
    Recent studies suggest that thrombophilic abnormalities and the use of oral contraceptives (OCs) are the leading causes of cerebral vein thrombosis (CVT)...
  24. ncbi Oral contraceptives, hormone replacement therapy and thrombosis
    F R Rosendaal
    Department of Hematology, Leiden University Medical Center, The Netherlands
    Thromb Haemost 86:112-23. 2001
    b>Oral contraceptives and hormone replacement therapy are used by hundreds of millions of women worldwide. Since the early 1960s it is known that female hormones increase the risk of venous thrombosis, myocardial infarction and stroke...
  25. ncbi The RATIO study: oral contraceptives and the risk of peripheral arterial disease in young women
    M A A J van den Bosch
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Thromb Haemost 1:439-44. 2003
    With regard to oral contraceptives, much research has concentrated on venous thrombosis and on the coronary and cerebral forms of atherosclerotic disease, while peripheral arterial disease (PAD) has received little attention...
  26. ncbi Estrogen fluctuations, oral contraceptives and borderline personality
    M Catherine DeSoto
    Department of Psychology, University of Northern Iowa, Cedar Falls, IA 50614 0505, USA
    Psychoneuroendocrinology 28:751-66. 2003
    ..Inventory, Professional Manual, 1991) and a questionnaire that assessed time in menstrual cycle and use of oral contraceptives, that is synthetic estrogens...
  27. doi Influence of gender and oral contraceptives intake on innate and inflammatory response. Role of neuroendocrine factors
    E Giraldo
    Department of Physiology, Faculty of Sciences, University of Extremadura, 06071 Badajoz, Spain
    Mol Cell Biochem 313:147-53. 2008
    ..was to determine differences between young men (M), and women in the follicular phase (W) and women taking oral contraceptives containing ethinylestradiol (CW) in the phagocytic process of neutrophils (chemotaxis, phagocytosis and ..
  28. ncbi Have oral contraceptives reduced the prevalence of acne? a population-based study of acne vulgaris, tobacco smoking and oral contraceptives
    Gregor B E Jemec
    Division of Dermatology, Department of Medicine, Roskilde University Hospital, Roskilde, Denmark
    Dermatology 204:179-84. 2002
    ..to describe the prevalence rate of acne among Danish adolescents and to study the possible influence of oral contraceptives (OC) and tobacco smoking on disease prevalence and severity...
  29. ncbi Oral contraceptive use and risk of breast cancer among women with a family history of breast cancer: a prospective cohort study
    Stephanie A N Silvera
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY 10461, USA
    Cancer Causes Control 16:1059-63. 2005
    ..Among women with any family history of breast cancer, ever use of oral contraceptives was associated with a 12% reduction in risk of breast cancer (95% confidence interval [CI]=0.73-1...
  30. doi Adolescents' cortisol responses to awakening and social stress; effects of gender, menstrual phase and oral contraceptives. The TRAILS study
    Esther M C Bouma
    Interdisciplinary Center for Psychiatric Epidemiology, University Medical Center Groningen CC 72, University of Groningen, Groningen, The Netherlands
    Psychoneuroendocrinology 34:884-93. 2009
    ..Effects of type of OC could not be studied because of low numbers of OC that were only progestin based...
  31. ncbi Serum folate and Vitamin B12 levels in women using modern oral contraceptives (OC) containing 20 microg ethinyl estradiol
    Marc W Sütterlin
    Department of Obstetrics and Gynecology, University of Wurzburg, Josef Schneider Str 4, D 97080 Wurzburg, Germany
    Eur J Obstet Gynecol Reprod Biol 107:57-61. 2003
    The effects of modern oral contraceptives (OC) on serum concentrations of folate and cobalamin are controversial.
  32. doi Oral contraceptives and colorectal cancer risk: a systematic review and meta-analysis
    Cristina Bosetti
    Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, 20156, Milan, Italy
    Hum Reprod Update 15:489-98. 2009
    ..Various studies have reported an inverse relation between oral contraceptive (OC) use and the risk of colorectal cancer, but the issue is still open...
  33. ncbi Progesterone receptor variant increases ovarian cancer risk in BRCA1 and BRCA2 mutation carriers who were never exposed to oral contraceptives
    I B Runnebaum
    Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany
    Pharmacogenetics 11:635-8. 2001
    b>Oral contraceptives have been shown to be protective against hereditary ovarian cancer...
  34. ncbi Parity and decreased use of oral contraceptives as predictors of asthma in young women
    M A Jenkins
    Department of Public Health, The University of Melbourne, Carlton, VIC 3053, Australia
    Clin Exp Allergy 36:609-13. 2006
    ..Asthma is more prevalent among males in childhood, but females report higher rates in adulthood. The reasons are unknown; although it has been hypothesized that hormonal factors may explain this sex-dependent risk of adult-onset asthma...
  35. ncbi Oral contraceptives as risk factors for cervical adenocarcinomas and squamous cell carcinomas
    J V Lacey
    National Cancer Institute, Bethesda, Maryland 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 8:1079-85. 1999
    To assess the hypothesis that oral contraceptives (OCs) increase the risk of cervical adenocarcinomas, we conducted a six-center case-control study of 124 patients with adenocarcinomas, 139 with squamous cell carcinomas, and 307 ..
  36. ncbi Association between sex hormone-binding globulin levels and activated protein C resistance in explaining the risk of thrombosis in users of oral contraceptives containing different progestogens
    Huib A A M van Vliet
    Department of Gynaecology and Reproductive Medicine, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Hum Reprod 20:563-8. 2005
    Epidemiological studies have shown that both the estrogen dose and progestogen type of oral contraceptives contribute to the increased risk of thrombosis in oral contraceptive users...
  37. ncbi Use of oral contraceptives and breast cancer risk: The Norwegian-Swedish Women's Lifestyle and Health Cohort Study
    Merethe Kumle
    Institute of Community Medicine, University of Tromsoe, 9037 Tromsoe, Norway
    Cancer Epidemiol Biomarkers Prev 11:1375-81. 2002
    Current use of oral contraceptives (OCs) has been reported to increase breast cancer risk slightly...
  38. doi Comparison of metabolic and inflammatory outcomes in women who used oral contraceptives and the levonorgestrel-releasing intrauterine device in a general population
    Laure Morin-Papunen
    Department of Obstetrics and Gynecology, University Hospital of Oulu, Oulu, Finland
    Am J Obstet Gynecol 199:529.e1-529.e10. 2008
    We compared the metabolic and cardiovascular parameters of a reference group of women with those of women who used 2 contraceptive regimes that are used worldwide: the levonorgestrel-releasing intrauterine device and oral contraceptives.
  39. pmc Antiepileptic drugs: coprescription of proconvulsant drugs and oral contraceptives: a national study of antiepileptic drug prescribing practice
    S D Shorvon
    Epilepsy Research Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 72:114-5. 2002
    To determine the frequency of coprescription of antiepileptic drugs (AEDs) and drugs with proconvulsant potential and of coprescription of AEDs and low dose oral contraceptives.
  40. ncbi Effects of oral contraceptives on peak exercise capacity
    Gretchen A Casazza
    Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California 94720, USA
    J Appl Physiol 93:1698-702. 2002
    ..53 +/- 0.21 to 2.25 +/- 0.18 l/min). In conclusion, 1) endogenous ovarian steroids have little effect on VO(2 peak), but 2) the exogenous ovarian steroids in OC decrease peak exercise capacity in moderately physically active young women...
  41. pmc Oral contraceptives and cervical cancer--further findings from the Oxford Family Planning Association contraceptive study
    K T Zondervan
    Department of Public Health and Primary Care, University of Oxford, Radcliffe Infirmary, UK
    Br J Cancer 73:1291-7. 1996
    ..results from the Oxford Family Planning Association contraceptive study regarding the association between oral contraceptives (OCs) and cervical neoplasia, after a 10 year follow-up of a cohort of 17,000 women...
  42. pmc Endometrial and ovarian cancer and oral contraceptives--findings in a large cohort study
    M P Vessey
    University Department of Public Health and Primary Care, Radcliffe Infirmary, Oxford, UK
    Br J Cancer 71:1340-2. 1995
    Many case-control studies have shown that oral contraceptives protect against endometrial cancer and epithelial ovarian cancer, but little information is available from cohort studies...
  43. doi Metformin, naltrexone, or the combination of prednisolone and antiandrogenic oral contraceptives as first-line therapy in hyperinsulinemic women with polycystic ovary syndrome
    Dijana Hadžiomerović-Pekić
    Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Innsbruck, Austria
    Fertil Steril 94:2385-8. 2010
    ....
  44. pmc Cancer risk among users of oral contraceptives: cohort data from the Royal College of General Practitioner's oral contraception study
    Philip C Hannaford
    Department of General Practice and Primary Care, University of Aberdeen, Aberdeen AB25 2AY
    BMJ 335:651. 2007
    ..To examine the absolute risks or benefits on cancer associated with oral contraception, using incident data...
  45. ncbi Oral contraceptives and risk of familial breast cancer
    Ketil Heimdal
    Unit of Medical Genetics, Norwegian Radium Hospital, University of Oslo
    Cancer Detect Prev 26:23-7. 2002
    ..For BRCA1 mutation carriers, the point estimate is a doubling of risk, but CI is wide and no conclusion may be drawn from this study alone...
  46. ncbi Oral contraceptive use, hormone replacement therapy, reproductive history and risk of colorectal cancer in women
    Geoffrey C Kabat
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY 10461, USA
    Int J Cancer 122:643-6. 2008
    ..Ever use of oral contraceptives at baseline was associated with a modest reduction in the risk of colorectal cancer (hazard ratio 0...
  47. ncbi Cycle characteristics after discontinuation of oral contraceptives
    C Gnoth
    Department of Reproductive Medicine and Gynecological Endocrinology, Frauenklinik Duesseldorf Benrath, Duesseldorf, Germany
    Gynecol Endocrinol 16:307-17. 2002
    Nearly 60% of the women between 20 and 40 years of age who do not want to conceive choose oral contraceptives (OCs) for contraception in Germany...
  48. ncbi Effects of two low-dose oral contraceptives containing ethinylestradiol and either desogestrel or levonorgestrel on serum lipids and lipoproteins with particular regard to LDL size
    T Foulon
    Départment de Biologie Intégrée, CHU, BP217, Grenoble Cedex 09, France
    Contraception 64:11-6. 2001
    This study was designed to determine the effects of two low-dose oral contraceptives, most frequently given in our area, monophasic desogestrel/ethinylestradiol (DG/EE) and triphasic levonorgestrel/ethinylestradiol (LNG/EE), on ..
  49. ncbi Use of oral contraceptives and mortality during 14 years' follow-up of Norwegian women
    Sidsel Graff-Iversen
    Norwegian Institute of Public Health, Oslo, Norway
    Scand J Public Health 34:11-6. 2006
    The aim was to evaluate total and cardiovascular disease (CVD) mortality in relation to use of oral contraceptives (OC) in a cohort of women with a relatively high prevalence of smoking and high serum lipid levels.
  50. ncbi Diurnal rhythm and effects of oral contraceptives on serum dehydroepiandrosterone sulfate (DHEAS) are related to alterations in serum albumin rather than to changes in adrenocortical steroid secretion
    K Carlstrom
    Department of Obstetrics and Gynecology, Clinical Research Center, Karolinska Institutet, Huddinge University Hospital, Sweden
    Scand J Clin Lab Invest 62:361-8. 2002
    ..Although of adrenocortical origin, serum DHEAS levels are decreased by oral contraceptives (OCs). DHEAS is strongly bound to serum albumin and has a very low metabolic clearance rate...
  51. ncbi Oral contraceptives are not an independent risk factor for cervical intraepithelial neoplasia or high-risk human papillomavirus infections
    Kari Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Anticancer Res 26:4729-40. 2006
    ..The aim of the present was study to analyse the risk estimates for OC users in order to develop several intermediate end-point markers in cervical carcinogenesis...
  52. ncbi Oral contraceptives, other methods of contraception, and risk reduction for ovarian cancer
    R B Ness
    Graduate School of Public Health and Pittsburgh Cancer Institute, University of Pittsburgh, USA
    Epidemiology 12:307-12. 2001
    b>Oral contraceptives reduce the risk of ovarian cancer, but the impact of other methods of contraception has not been fully explored. This population-based, case-control study involved women 20-69 years of age who had ever had intercourse...
  53. pmc Improvement in quality-of-life questionnaire measures in obese adolescent females with polycystic ovary syndrome treated with lifestyle changes and oral contraceptives, with or without metformin
    Miranda Harris-Glocker
    Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 601 Elmwood Avenue, Box 668, Rochester, NY 14642, USA
    Fertil Steril 93:1016-9. 2010
    We studied the effect of metformin or placebo in a lifestyle modification program combined with oral contraceptives (OC) on quality-of-life parameters measured by the polycystic ovary syndrome (PCOS) questionnaire in obese adolescent ..
  54. ncbi Hypertension, genotype and oral contraceptives
    Paolo Mulatero
    Department of Medicine and Experimental Oncology, Hypertension Unit, San Vito Hospital, University of Torino, S San Vito 34 10133 Torino, Italy
    Pharmacogenomics 3:57-63. 2002
    ..In this article, the epidemiology and the pathogenesis of OCIH are reviewed with particular emphasis on the genetic influence in light of the most recent studies in this field...
  55. ncbi Oral contraceptives can cause falsely low vitamin B(12) levels
    J Gardyn
    Hematology Unit, Golda Hasharon Campus, Rabin Medical Center, Petah Tikva, Israel
    Acta Haematol 104:22-4. 2000
    ..We evaluated 10 consecutive healthy women on oral contraceptives (OC) who had falsely low vitamin B(12) levels, as reflected by normal urine methylmalonic acid and plasma ..
  56. ncbi No sex-related differences but significant inhibition by oral contraceptives of CYP2C19 activity as measured by the probe drugs mephenytoin and omeprazole in healthy Swedish white subjects
    K Laine
    Department of Medical Laboratory Sciences and Technology, Karolinska Institutet, Huddinge University Hospital, Sweden
    Clin Pharmacol Ther 68:151-9. 2000
    Although it is known that the use of oral contraceptives inhibits oxidative drug metabolism, there is little information regarding their effect on CYP2C19 activity...
  57. doi The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis
    Hugo Maia
    Centro de Pesquisa e Assistência em Reprodução Humana CEPARH, Salvador, Bahia, Brazil
    Gynecol Endocrinol 24:123-8. 2008
    To determine the effect of oral contraceptives containing gestodene on aromatase expression in the endometrium of patients diagnosed with endometriosis.
  58. ncbi Effect of oral contraceptives on endothelial function in the peripheral microcirculation of healthy women
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Italy
    J Hypertens 21:2275-80. 2003
    ..We assessed whether third-generation oral contraceptive (OC) treatment (30 microg ethinylestradiol + 75 microg gestodene daily) could affect the endothelial function of healthy women...
  59. pmc Benefits and risks of third-generation oral contraceptives
    E S LeBlanc
    Department of Internal Medicine, Portland Veterans Affairs Medical Center, Portland, OR, USA
    J Gen Intern Med 14:625-32. 1999
    OBJECTIVE: To evaluate the risks and benefits of third-generation oral contraceptives. DATA SOURCES: A MEDLINE search was done for English language articles published from 1985 through 1998 relating to the side-effect profile of third-..
  60. ncbi Over-the-counter use of oral contraceptives in Kuwait
    M A Shah
    Health Information Administration, Kuwait University, Kuwait
    Int J Gynaecol Obstet 73:243-51. 2001
    ..However, there is a need for better packaging and instructions that would enable high-risk women to identify themselves and to use OCPs under physician supervision...
  61. doi The effects of oral contraceptives including low-dose estrogen and drospirenone on the concentration of leptin and ghrelin in polycystic ovary syndrome
    Nevin Sagsoz
    Department of Obstetrics and Gynecology, Kirikkale University Faculty of Medicine, Kirikkale, Turkey
    Fertil Steril 92:660-6. 2009
    To evaluate short-term leptin and ghrelin concentrations in women with polycystic ovary syndrome (PCOS) who use low-dose oral contraceptives containing drospirenone.
  62. doi Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies
    Hugo Maia
    Centro de Pesquisas e Assistencia em Reproducao Humana CEPARH, 40210 341 Salvador, Bahia, Brazil
    Contraception 78:479-85. 2008
    ..The study was conducted to evaluate vascular endothelial growth factor (VEGF), Cox-2 and aromatase expression in the endometrium of uteri with myomas and other associated pathologies...
  63. ncbi Pro-inflammatory effects of oestrogens during use of oral contraceptives and hormone replacement treatment
    C Kluft
    Gaubius Laboratory, TNO PG, Vascular and Connective Tissue Research, Zernikedreef 9, P O Box 2215, 2333 CK Leiden, The Netherlands
    Vascul Pharmacol 39:149-54. 2002
    The effects of two third-generation monophasic combined oral contraceptives (COC) and a postmenopausal hormone replacement therapy (HRT) consisting of 2 mg 17 beta-oestradiol on the plasma level of the acute-phase indicator C-reactive ..
  64. ncbi Risk of breast cancer associated with short-term use of oral contraceptives
    Suzanne G Folger
    Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Cancer Causes Control 18:189-98. 2007
    ..To estimate breast cancer risk associated with short-term (<6 months) oral contraceptive use, and explore variation in estimates by use characteristics and medical, menstrual, and reproductive history...
  65. doi Oral contraceptives and family history of breast cancer
    Mary E Gaffield
    Department of Reproductive Health and Research, World Health Organization, 1211 Geneva 27, Switzerland
    Contraception 80:372-80. 2009
    ..Questions remain regarding whether oral contraceptive (OC) use among women with a family history of breast cancer increases disease risk...
  66. doi Does use of estrogens decrease the Breslow thickness of melanoma of the skin? Oral contraceptives and hormonal replacement therapy
    Elsje R Koomen
    Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands
    Melanoma Res 19:327-32. 2009
    ..This association was shown for both oral contraceptives (OC) and hormonal replacement therapy (HRT)...
  67. ncbi Non-contraceptive benefits of oral contraceptives
    Johannes C Huber
    University of Vienna School of Medicine, Department of Gynaecologic Endocrinology and Reproductive Medicine, Vienna, Austria
    Expert Opin Pharmacother 9:2317-25. 2008
    There is increasing awareness of the opportunity that many contraceptive interventions may provide for additional health benefits. However, treatment of medical problems with oral contraceptives (OCs) is often an 'off-label' practice.
  68. doi Use of oral contraceptives in pregnancy and major structural birth defects in offspring
    DOROTHY KIM WALLER
    The University of Texas, Houston Health Science Center, School of Public Health, Houston, TX 77030, USA
    Epidemiology 21:232-9. 2010
    b>Oral contraceptives (OCs) are the most commonly used reversible contraceptive method among US women...
  69. ncbi Oral contraceptives and thrombotic disease: risk of venous thromboembolism
    F M Helmerhorst
    Department of Obstetrics, Gynecology and Reproductive Medicine, Leiden University, The Netherlands
    Thromb Haemost 78:327-33. 1997
    ..The clinical consequence is therefore that second-generation OCs are the first choice in prescription to first-time users...
  70. ncbi Oral contraceptives improve endothelial function in amenorrheic athletes
    Anette Rickenlund
    Research Laboratory for Reproductive Health, Department of Obstetrics and Gynecology, C4 U1, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    J Clin Endocrinol Metab 90:3162-7. 2005
    ..The aim of this study was to evaluate the effects of oral contraceptives (OCs) on endothelial function measured as flow-mediated dilatation (FMD) of the brachial artery, the lipid ..
  71. pmc Effects of oral contraceptives on sympathetic nerve activity during orthostatic stress in young, healthy women
    Jason R Carter
    Dept of Exercise Science, Michigan Technological Univ, 1400 Townsend Drive, Houghton, MI 49931, USA
    Am J Physiol Regul Integr Comp Physiol 298:R9-R14. 2010
    ..The purpose of the present study was to determine whether oral contraceptives (OC) influence sympathetic neural activation during an orthostatic challenge...
  72. ncbi Early onset vulvar Lichen Sclerosus in premenopausal women and oral contraceptives
    Andreas R Günthert
    University of Goettingen, Department Obstetrics and Gynaecology, Robert Koch Str 40, 37075 Goettingen, Germany
    Eur J Obstet Gynecol Reprod Biol 137:56-60. 2008
    ..During the last decade an increase of LS in young women has been suspected. Aim of this study was to evaluate data of premenopausal women with early onset LS to find potential risk factors focussing on the use of oral contraceptives.
  73. doi Intrinsic coagulation activation and the risk of arterial thrombosis in young women: results from the Risk of Arterial Thrombosis in relation to Oral contraceptives (RATIO) case-control study
    B Siegerink
    Department of Clinical Epidemiology, LUMC, Leiden, The Netherlands
    Circulation 122:1854-61. 2010
    ..This study aims to determine the risks of arterial thrombosis conferred by increased activation of intrinsic coagulation proteins in young women and the effect of oral contraceptive use on this association...
  74. ncbi Oral contraceptives use and the risk of myocardial infarction: a meta-analysis
    Yousef S Khader
    Department of Biostatistics, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA
    Contraception 68:11-7. 2003
    ..48 [95% confidence interval (CI): 1.91-3.22] compared to never-users. The risk of MI for past OC users is not significantly different from that for never-users, overall OR = 1.15 (95% CI: 0.98-1.35; p = 0.096)...
  75. ncbi Effect of the menstrual cycle and oral contraceptives on cyclooxygenase-2 expression in the endometrium
    Hugo Maia
    CEPARH, Salvador, Bahia, Brazil
    Gynecol Endocrinol 21:57-61. 2005
    To compare the expression of cyclooxygenase-2 (COX-2) and proliferation markers (Ki-67) in the endometrium of patients with ovulatory cycles with those in the endometrium of patients using oral contraceptives.
  76. ncbi Influence of smoking and oral contraceptives on bone mineral density and bone remodeling in young women: a 2-year study
    C Elgán
    Department of Nursing, Lund University, P O Box 157, S 221 00, Lund, Sweden
    Contraception 67:439-47. 2003
    The objective of the study was to explore the influence of menstrual irregularities, oral contraceptives and smoking on bone mineral density (BMD) development and bone turnover with time...
  77. doi Association between efficacy and body weight or body mass index for two low-dose oral contraceptives
    Ronald T Burkman
    Department of Obstetrics and Gynecology, Baystate Medical Center, Springfield, MA 01199, USA
    Contraception 79:424-7. 2009
    ..This analysis investigated the association of oral contraceptive efficacy with body weight and body mass index (BMI) for hypothesis-generating purposes...
  78. ncbi Risk of venous thromboembolism from oral contraceptives containing gestodene and desogestrel versus levonorgestrel: a meta-analysis and formal sensitivity analysis
    S Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Contraception 64:125-33. 2001
    Controversy exists regarding whether oral contraceptives (OCs) containing desogestrel and gestodene are associated with an increased risk of venous thromboembolism (VTE) versus OCs containing levonorgestrel...
  79. ncbi Cyclooxygenase-2 expression in the endometrium and its relationship to bleeding in users of continuous oral contraceptives
    Hugo Maia
    Centro de Pesquisa e Assistência em Reprodução Humana CEPARH, Salvador, Bahia, Brazil
    Gynecol Endocrinol 22:96-100. 2006
    The objective of the present study was to investigate whether or not the presence of irregular bleeding during use of oral contraceptives (OC) is associated with increased cyclooxygenase-2 (COX-2) expression.
  80. ncbi Oral contraceptives and DDAVP nasal spray: patterns of use in managing vWD-associated menorrhagia: a single-institution study
    Lawrence S Amesse
    Section of Pediatric Adolescent Gynecology, Division of Reproductive Endocrinology and Infertility, Wright State University School of Medicine, Dayton, Ohio 45409, USA
    J Pediatr Hematol Oncol 27:357-63. 2005
    ..Subjects with vWD type 1 (n = 36) administered either oral contraceptives (OC) or intranasal desmopressin acetate (DDAVP) and followed from 6 months to 4 years were selected for ..
  81. ncbi Systematic review of case-control studies: oral contraceptives show no effect on melanoma risk
    A Pfahlberg
    Department of Medical Statistics, University of Gottingen, Germany
    Public Health Rev 25:309-15. 1997
    ....
  82. doi Effect of second and third generation oral contraceptives on C-reactive protein, lipids and apolipoproteins in young, non-obese, non-smoking apparently healthy women
    Magdalena Krintus
    Department of Laboratory Medicine, Collegium Medicum, Nicolaus Copernicus University, ul M Sklodowskiej Curie 9, 85 094 Bydgoszcz, Poland
    Clin Biochem 43:626-8. 2010
    Third generation oral contraceptives (OC) may increase the risk of cardiovascular events in healthy young women.
  83. pmc Oral contraceptives, hormone replacement therapy and the risk of colorectal cancer
    E Fernandez
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Br J Cancer 73:1431-5. 1996
    The relationship between oral contraceptives (OCs), menopausal hormone replacement therapy (HRT) and the risk of colorectal cancer was investigated in a case-control study conducted in northern Italy between 1985 and 1992 on 709 women ..
  84. ncbi Effects of oral contraceptives on total serum proteins, albumin, globulins and cholesterol levels in Ibadan, Nigeria
    K A Obisesan
    Department of Obstetrics and Gynaecology, College of Medicine University of Ibadan, Nigeria
    West Afr J Med 21:197-9. 2002
    ..protein, albumin, globulin, albumin/globulin ratio and cholesterol levels were determined in 25 subjects on oral contraceptives and 25 controls...
  85. pmc Effects of oral contraceptives on diurnal profiles of insulin, insulin-like growth factor binding protein-1, growth hormone and cortisol in endurance athletes with menstrual disturbance
    A Rickenlund
    Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Hum Reprod 25:85-93. 2010
    ....
  86. pmc Effect of low-dose oral contraceptives on metabolic risk factors in African-American women
    Barbara A Frempong
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 93:2097-103. 2008
    ..The effect of oral contraceptive pill (OCP) use on cardiovascular risk in African-American women is unknown...
  87. doi Acute renal vein thrombosis, oral contraceptives, and protein S deficiency: a successful catheter-directed thrombolysis
    Hyung Kee Kim
    Division of Transplantation and Vascular Surgery, Department of Surgery, Kyungpook National University School of Medicine, Daegu, South Korea
    Ann Vasc Surg 23:687.e1-4. 2009
    ..a case of acute RVT with multiple pulmonary emboli that occurred in a 40-year-old woman who was taking oral contraceptives and was subsequently found to have protein S deficiency...
  88. ncbi Decreased mechanical pain threshold in the vestibular mucosa of women using oral contraceptives: a contributing factor in vulvar vestibulitis?
    Nina Bohm-Starke
    Division of Obstetrics and Gynaecology, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden
    J Reprod Med 49:888-92. 2004
    To analyze possible differences in somatosensory perception in the vestibular mucosa in healthy women associated with the use of oral contraceptives.
  89. pmc Hormonal content and potency of oral contraceptives and breast cancer risk among young women
    M D Althuis
    Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 7084, EPS MSC 7234, Rockville, MD 20852 USA
    Br J Cancer 88:50-7. 2003
    ..Hormonal content and potency of combination oral contraceptives used for the longest duration within 5 years of interview for breast cancer cases aged 20-44 years (N=1640) ..
  90. ncbi Oral contraceptives and the risk of ductal breast carcinoma in situ
    Elizabeth B Claus
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Breast Cancer Res Treat 81:129-36. 2003
    ..No study has examined the relationship between oral contraceptive use and the risk of non-invasive breast carcinoma, that is, breast carcinoma in situ...
  91. ncbi Association between the current use of low-dose oral contraceptives and cardiovascular arterial disease: a meta-analysis
    Jean Patrice Baillargeon
    Department of Internal Medicine, Universite de Sherbrooke, Endocrine Division, 3001 12th North Avenue, Sherbrooke, Quebec J1H 5N4, Canada
    J Clin Endocrinol Metab 90:3863-70. 2005
    The long-term cardiovascular safety of widely used oral contraceptives (OCs) is still debated, and no meta-analysis assesses the modern use of OCs and the associated cardiovascular risks.
  92. ncbi Assessment of DNA damage in women using oral contraceptives
    Aydan Biri
    Department of Obstetric and Gynecology, School of Medicine, Gazi University, Ankara, Turkey
    Mutat Res 521:113-9. 2002
    ....
  93. pmc Effect of injectable and oral contraceptives on serum lipids
    Abbey B Berenson
    Department of Obstetrics and Gynecology, the Center for Interdisciplinary Research in Women s Health, The University of Texas Medical Branch, Galveston, Texas 77555 0587, USA
    Obstet Gynecol 114:786-94. 2009
    To estimate the effects of using depot medroxyprogesterone acetate (DMPA) or oral contraceptives (OCs) containing 20 micrograms ethinyl estradiol and 0.15 mg desogestrel on serum lipid levels.
  94. doi Facilitated acquisition of the classically conditioned eyeblink response in women taking oral contraceptives
    Kevin D Beck
    Neurobehavioral Research Laboratory, VA New Jersey Health Care System, East Orange, New Jersey 07018, USA
    Behav Pharmacol 19:821-8. 2008
    ..Therefore, in this preliminary study we assessed learning in women who take oral contraceptives and those who do not during the three phases of the menstrual cycle: early, middle, and later cycle...
  95. doi Venous thromboembolism in young female while on oral contraceptives: high frequency of inherited thrombophilia and analysis of thrombotic events in 400 czech women
    Petr Dulicek
    Second Department of Internal Medicine Division of Hematology, University Hospital and Medical Faculty of Charles University, Hradec Kralove, Czech Republic
    Clin Appl Thromb Hemost 15:567-73. 2009
    ..Oral contraceptive use is a common risk factor for venous thromboembolism in women of reproductive age. The presence of inherited thrombophilia further increases this risk...
  96. ncbi Effects of putative male pheromones on female ratings of male attractiveness: influence of oral contraceptives and the menstrual cycle
    Frances Thorne
    Human Cognitive Neuroscience Unit, Division of Psychology, Northumbria University, Newcastle upon Tyne, UK
    Neuro Endocrinol Lett 23:291-7. 2002
    ..The results of this study suggest that exposure to natural male axillary pheromones can significantly enhance female perceptions of various aspects of male attractiveness...
  97. doi Risk of hyperkalemia in women taking ethinylestradiol/drospirenone and other oral contraceptives
    Jeanne Loughlin
    Ingenix i3 Drug Safety, Waltham, MA 02451, USA
    Contraception 78:377-83. 2008
    ..We sought to determine whether EE/DRSP use might lead to adverse effects possibly attributable to hyperkalemia...
  98. ncbi [Use of oral contraceptives and increased risk of cervical cancer]
    C E Schmeink
    Universitair Medisch Centrum St Radboud, afd Verloskunde en Gynaecologie, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 152:1717-8. 2008
    A recently published meta-analysis and a large cohort study showed independently that use of oral contraceptives (OC) leads to an increased relative risk (RR) of cervical cancer. This RR increased with the duration of OC use and was 1...
  99. doi Risk of venous thromboembolism and the use of dienogest- and drospirenone-containing oral contraceptives: results from a German case-control study
    Jürgen Dinger
    Director, ZEG Berlin Center for Epidemiology and Health Research, Invalidenstrasse 115, 10115 Berlin, Germany
    J Fam Plann Reprod Health Care 36:123-9. 2010
    ..e. containing < or =30 microg EE), particularly oral contraceptives containing levonorgestrel (LNG)...
  100. ncbi Oral contraceptives: a risk factor for uncontrolled blood pressure among hypertensive women
    Jaqueline Neves Lubianca
    Programa de Pós Graduação em Ciências Médicas Clínica Médica, 2 degrees andar Faculde de Medicina da Universidade Federal do Rio Grande do Sul UFRGS, Rua Ramiro Barcelos 2400, CEP 90035 003, Porto Alegre, RS, Brazil
    Contraception 67:19-24. 2003
    ..was to assess the association between systolic and diastolic blood pressure (SBP and DBP) and the use of oral contraceptives (OC) in hypertensive women...
  101. ncbi Different oral contraceptives and voice quality--an observational study
    Ofer Amir
    Department of Communication Disorders, Sackler Faculty of Medicine, Tel Aviv University, 52621 Israel
    Contraception 71:348-52. 2005
    The classical literature on endocrine effect on voice considers oral contraceptives (OCs) as a risk factor for voice. However, recent studies revealed no adverse effect of new-generation OCs on voice...

Research Grants64

  1. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..cycle-induced changes in cardiovascular risk factors and how inhibiting ovarian activity via hormonal oral contraceptives affects these factors...
  2. Vitamin B6 Effects on One-Carbon Metabolism
    Jesse F Gregory; Fiscal Year: 2013
    ..segment of the population, women of reproductive age, has compromised B6 status associated with the use of oral contraceptives (OC)...
  3. A Novel Target for the Treatment of Endometriosis
    Paul D Crowe; Fiscal Year: 2011
    ..therapy carries a significant risk of bone loss, is not obviously more effective than treatment with oral contraceptives, and also has a 50% or higher recurrence of symptoms within 5 years...
  4. Innate immunity predictors of HIV: the role of contraception, pregnancy and HSV-2
    Charles Morrison; Fiscal Year: 2013
    ..HC), including the injectable progestin depot medroxyprogesterone acetate (DMPA) and combined oral contraceptives (COCs), and pregnancy have been associated with increased risk of HIV in some, but not all, large ..
  5. Risk Factors for Urinary Incontinence in Women
    Francine Grodstein; Fiscal Year: 2010
    ..may increase risk of developing UI, we also propose novel and detailed analyses of the relation between oral contraceptives and UI in premenopausal women...
  6. Role of NRF-1 in Estrogen-Induced Breast Cancer Pathogenesis
    Deodutta Roy; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Exposure to exogenous estrogen used in oral contraceptives (OCs) and hormone therapy (HT) is a major risk factor for breast cancer initiation and progression in women including veteran population...
  7. FACTOR VA INTERACTIONS REGULATING PROTHROMBIN ACTIVATION
    Paul E Bock; Fiscal Year: 2010
    ..defects in the coagulation factors, factor V, protein C, protein S, and prothrombin, and women taking oral contraceptives have a higher risk of clotting in veins...
  8. Smoking, Sex Hormones and Pregnancy
    Sharon S Allen; Fiscal Year: 2013
    ..between sex hormones and smoking-related symptomatology in pregnancy and, a more controlled clinical model, oral contraceptives. We will address this objective by assessing two specific study aims: (1) investigate the association ..
  9. Gonadotropins &Cox-2 in Ovarian Cancer Prevention
    XIANGXI MIKE XU; Fiscal Year: 2013
    ..cancer risk factors, such as high cancer incidence in peri- postmenopausal ages and preventive activity of oral contraceptives. However, the mechanisms for these well-established ideas remain obscure, and experimental systems are ..
  10. Prevention of Menopause-Related Ovarian Epithelial Cancer
    Elizabeth R Smith; Fiscal Year: 2010
    ..where uninterrupted ovulation frequency and non-parity increase the risk, and parity and the use of oral contraceptives clearly reduce the risk...
  11. Oral contraceptive use by formulation and breast cancer risk by subtype
    DIANA SM BUIST; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Project Summary/Abstract Approximately 82% of US women have ever used oral contraceptives (OCs) during their reproductive lives and there is a modest increased risk of breast cancer associated with ..
  12. A Pooled Analysis to Identify New Ovarian Cancer Risk Factors
    Celeste Leigh Pearce; Fiscal Year: 2010
    ..While it is clear that exogenous hormones in the form of oral contraceptives (OCs) are associated with decreased risk of epithelial ovarian cancer (ovarian cancer), the situation with ..
  13. Oral Contraceptives in the Etiopathogenesis of Crohn's Disease
    Hamed Khalili; Fiscal Year: 2013
    ..In prior work, the candidate has demonstrated that use of oral contraceptives (OC) is associated with an increased risk of developing CD...
  14. Oral Contraceptive Use and Fractures Around the Menopausal Transition
    Delia Scholes; Fiscal Year: 2012
    ..Combined oral contraceptives (OCs), the leading method of contraception in the U.S...
  15. Modulation of Hormonal and Systemic Immunity by Hormonal Contraceptive Use
    Thomas L Cherpes; Fiscal Year: 2013
    ..generate a fresh approach to this research question that focuses on the immunomodulatory effects of DMPA, oral contraceptives (OC), and levonorgestrel-containng intrauterine devices (LNG-IUD) that may impair host responses against ..
  16. Long-term Follow-Up of Infertility Patients: A Pilot Study
    Francine Grodstein; Fiscal Year: 2010
    ..Although health effects of hormonal treatments such as oral contraceptives and postmenopausal hormone therapy have been well- documented, surprisingly little is known regarding the ..
  17. Effects of Continuous versus Cyclic Oral Contraceptives on Mammary Tumor Growth
    PATRICIA ANN MASSO-WELCH; Fiscal Year: 2013
    ..The primary outcome of these studies is to define the effects of continuous dosing of OC on primary and metastatic mammary tumor growth in two distinct mouse mammary tumor models, relative to no OC or cyclic dosing of OC. ..
  18. Prolactin as a lacrimal gland immunomodulator
    Joel Schechter; Fiscal Year: 2009
    ..puerperium, and lactation, and in a setting of elevated systemic E2 mimicking that of a woman using oral contraceptives. Together, Aims 1 and 2 test the hypothesis that certain endocrinological states allow the system to ..
  19. Mechanisms of Prevention of Ovarian Cancer by Oral Contraceptives
    Malcolm C Pike; Fiscal Year: 2013
    ....
  20. Elucidating the mechanism of ERbeta in colon carcinogenesis
    CECILIA MARIE WILLIAMS; Fiscal Year: 2013
    ..hormone replacement therapy in women unexpectedly resulted in reduced risk of colorectal cancer, use of oral contraceptives is associated with a lower incidence of this disease, and estradiol has been shown to reduce the formation ..
  21. Reproductive Hormones and their impact on HIV-1 acquisition
    Bharat Ramratnam; Fiscal Year: 2013
    ..during different phases of the menstrual cycle, before/after starting hormonal contraception (high dose oral contraceptives vs. low dose oral contraceptives vs. DMPA) and before/after starting estrogenic creams...
  22. Fertility and Oral Contraceptive Use Study (FOCUS)
    Larissa R Brunner Huber; Fiscal Year: 2010
    b>Oral contraceptives (OCs) are the most popular reversible method of contraception in the US...
  23. Ovulation, inclusion cysts, and p53 mutations in a mouse model of ovarian cancer
    Joanna E Burdette; Fiscal Year: 2010
    ..For example, pregnancy, breast-feeding, use of oral contraceptives, and early menopause all reduce the risk for developing ovarian cancers...
  24. Fat Mediated Modulation of Reproductive and Endocrine Function in Young Athletes
    Madhusmita Misra; Fiscal Year: 2013
    ..Despite the prevalent practice of prescribing oral contraceptives in AA, there is a paucity of data regarding benefits of this intervention in teenagers...
  25. Hormonal Contraception and HIV Acquisition: An IPD Meta-analysis
    Charles Morrison; Fiscal Year: 2012
    ..use including the injectable progestin, depot-medroxyprogesterone acetate (DMPA), and combined oral contraceptives (OCs)...
  26. A novel vaginal ring to prevent HIV and HSV-2 infection, as well as pregnancy
    THOMAS MICHAEL ZYDOWSKY; Fiscal Year: 2013
    ..prevents SHIV-RT and HSV-2 infection in vivo;and LNG is the most widely used progestin in approved oral contraceptives (in combination with ethinyl estradiol or alone in low dose progestin only contraceptives)...
  27. Levonorgestrel intrauterine system versus oral contraceptives for heavy menses
    Kristen A Matteson; Fiscal Year: 2013
    ..In the United States, combined oral contraceptives and the levonorgestrel intrauterine system are the two most commonly prescribed non-surgical treatments for ..
  28. RCT of a Novel Oral Contraceptive Initiation Method
    Carolyn Westhoff; Fiscal Year: 2004
    Description (provided by applicant): Pregnancy rates are high among acceptors of oral contraceptives despite the effectiveness of the method...
  29. GENETIC SUSCEPTIBILITY TO HORMONAL CARCINOGENESIS
    ROLF PERSSON; Fiscal Year: 2000
    ..factors-like nulliparity, late age at first birth, early menarche, late menopause, long-term use of oral contraceptives or hormone replacement therapy-together with first-degree family history, explain only half of all breast ..
  30. MUTATIONS, HORMONE THERAPY, AND VENOUS THROMBOEMBOLISM
    Bruce Psaty; Fiscal Year: 2001
    ..In pre-menopausal women, the use of oral contraceptives is associated with a 4-fold increase in VTE risk, and the joint effects of oral contraceptive use and ..
  31. TRACE ELEMENT NUTRITION OF THE LENS--ZINC
    J Bentley; Fiscal Year: 1990
    ..diseases, including diabetes mellitus and diarrheal disease, and the use of some drugs such as ethanol, oral contraceptives and thiazide diuretics. Some such conditions are known to result in a predisposition to cataracts in humans...
  32. DIET, ACTIVITY & REPRODUCTION--RISKS FOR RECTAL CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 1999
    ..associated with an increased risk of colon cancer; 4) nulliparity, late age at first birth and non-use of oral contraceptives are associated with an increased risk of colon cancer; 5) family history of colon cancer is associated with ..
  33. ORAL CONTRACEPTIVES AND THROMBOEMBOLIC DISEASE
    Stephen Sidney; Fiscal Year: 2000
    ..Finally, they point out that it would provide estimates of the prevalence of the Factor V Leiden mutation and its impact on thromboembolic disease in a racially heterogeneous California study population. ..
  34. Treatment of Endometriosis-Associated Pelvic Pain
    David Guzick; Fiscal Year: 2007
    ..As an alternative, the continuous use of oral contraceptives has been advocated as a practical, inexpensive strategy for long-term medical treatment of endometriosis-..
  35. ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 2007
    ..Since P are widely used in oral contraceptives and in postmenopausal hormone replacement therapy it is critically important that their mechanims of action ..
  36. A RCT of LNG-IUD vs. DMPA for young postpartum women
    Nancy Stanwood; Fiscal Year: 2005
    ..DMPA) is a highly effective method of contraception, with better compliance and lower pregnancy rates than oral contraceptives. It is commonly recommended to young women for postpartum contraception...
  37. ECTOPY, HORMONAL CONTRACEPTION AND STD'S IN ADOLESCENTS
    Ligia Peralta; Fiscal Year: 2004
    ..Cervical ectopy and use of oral contraceptives (OC), both common in adolescence, are risk factors for chlamydia, the most common inflammatory STD...
  38. Inflammatory Markers in Circulation and Ovarian Cancer Risk
    Alan Arslan; Fiscal Year: 2009
    ..Conversely, factors that suppress ovulation (pregnancy, lactation, and use of oral contraceptives) and possibly use of anti-inflammatory medications are associated with reduced risk...
  39. ASSESSING RECALL ACCURACY FOR PRESCRIPTION MEDICATIONS
    Suzanne West; Fiscal Year: 1991
    ..Except for drugs such as estrogens and oral contraceptives, little attention has been focused on the validity of patient histories of prior drug exposures...
  40. ORAL CONTRACEPTIVES: EFFECT ON VITAMIN C METABOLISM
    K Lei; Fiscal Year: 1980
    ..The in vitro reactions will be monitored by measuring the quantities of products formed or the remaining substrate...
  41. PAIN AND ANALGESIC RESPONSE--SEX AND HORMONE VARIATIONS
    Sandra Comer; Fiscal Year: 2002
    ..Further, each study will compare normally-cycling women to women maintained on oral contraceptives and to men...
  42. 60-HZ MAGNETIC FIELDS AND HORMONE LEVELS IN WOMEN
    Scott Davis; Fiscal Year: 2000
    ..not been previously diagnosed with breast cancer, who reports regular menstrual periods, who is not taking oral contraceptives or hormone preparations, and who normally sleeps with an electric blanket during the winter months...
  43. ORAL CONTRACEPTIVES AND INFLAMMATORY BOWEL DISEASE RISK
    Edward Boyko; Fiscal Year: 1992
    The main goals of this study are (1) to determine whether current and past use of oral contraceptives alter a woman's risk of developing ulcerative colitis (2) to determine whether alteration in risk due to oral contraceptive use varies ..
  44. LONG ORAL CONTRACEPTIVE USE/VITAMIN B-6 PREGNANCY NEEDS
    Avanelle Kirksey; Fiscal Year: 1980
    ..nutritional status of women who may be at risk of a deficiency of the vitamin following long-term use of oral contraceptives (OCA)...
  45. ROLE OF GONADAL STEROIDS IN LIVER CARCINOGENESIS
    JAMES YAGER; Fiscal Year: 1980
    Recently, numerous reports have appeared describing the presence of liver-cell adenomas in women using oral contraceptives. Animal studies conducted at the time these agents were originally tested foretold of the possibility, but it was ..
  46. ETHINYL ESTRADIOL AND HEPATOCARCINOGENESIS
    JAMES YAGER; Fiscal Year: 2003
    Prolonged use by women of oral contraceptives containing the synthetic ethinyl estradiol (EE) is associated with a modest increased risk of developing liver tumors...
  47. CHEMOPREVENTION OF BREAST AND OVARIAN CANCER
    Powel Brown; Fiscal Year: 2004
    ..2) Chemoprevention of Ovarian Cancer: Marker Modulation using Fenretinide and Oral Contraceptives. This project will investigate whether oral contraceptives, the synthetic retinoid 4HPR or their ..
  48. PROSPECTIVE STUDY OF STRESS AND MOOD IN CHRONIC HEADACHE
    Edward Blanchard; Fiscal Year: 1999
    ..and, when appropriate, indications of two key points in the menstrual cycle of premenopausal women not on oral contraceptives: time of ovulation and time of onset of menstruation...
  49. CatSper: Novel target for an oral contraceptive
    JAYHONG CHONG; Fiscal Year: 2003
    Hydra Biosciences Inc. will develop a novel class of non-hormonal, oral contraceptives based on the discovery by our co-founder, David Clapham, M.D./ Ph.D., of a sperm specific ion channel, CatSper...
  50. HPV methylation: a biomarker of cervical lesion progress
    Anna Giuliano; Fiscal Year: 2003
    ..2) whether methylation patterns of HPV are related to viral load; 3) the factors (such as smoking, oral contraceptives, and co-infections) associated with HPV methylation status; 4) whether HPV DNA methylation status is ..
  51. CASE-CONTROL STUDY OF ADENOCARCINOMA OF THE CERVIX
    Ruth Peters; Fiscal Year: 1991
    The LONG-TERM OBJECTIVE of this proposal is to conduct a case-control study to investigate the role of oral contraceptives (OC's) in the etiology of adenocarcinoma of the uterine cervix...
  52. A NOVEL ORAL CONTRACEPTIVE INITIATION METHOD
    Patricia Murphy; Fiscal Year: 2000
    ..The main reason is non-use of effective contraceptives. Oral contraceptives are one of the most effective of methods, but even after they are prescribed, pregnancy rates remain high...
  53. ORAL CONTRACEPTION AND ATHEROSCLEROSIS
    Michael Adams; Fiscal Year: 1993
    While oral contraceptives have been in widespread use for about 25 years, the effects of these compounds on risk of coronary heart disease (CHD) remain unclear...
  54. POSTMENOPAUSAL PROGESTINS & THE RISK OF CORONARY DISEASE
    Bruce Psaty; Fiscal Year: 1992
    ..Progestins are probably responsible for the increased risk of myocardial infarction (MI) in women on oral contraceptives. Does the addition of progestins pose a risk for fatal and non-fatal MI in post-menopausal women on ..
  55. BRCA1, ORAL CONTRACEPTIVES, AND HORMONAL RISK FACTORS
    Leslie Bernstein; Fiscal Year: 2003
    ..abstract_text> ..
  56. ORAL CONTRACEPTIVES AND CANCER
    James Schlesselman; Fiscal Year: 1991
    ..Finally, estimates of cumulative cancer incidence will be computed to evaluate the overall public health importance of apparently causal relationships...
  57. NIGHT SHIFT WORKERS AND HORMONE LEVELS IN WOMEN
    Scott Davis; Fiscal Year: 2006
    ..ages of 20 and 40, employed for at least 20 hours/week, resident of King or Snohomish County, do not take oral contraceptives or other hormone preparations, and have no personal history of breast cancer...
  58. Psychological Symptoms and Oral Contraceptive Continuation in Young Minorities
    Kelli Stidham Hall; Fiscal Year: 2009
    ..Although oral contraceptives (OCs) are the safest and most effective method of birth control, their use by sexually active adolescents ..
  59. Mechanisms underlying the anatomically specific actions of estradiol in brain.
    KEITH LANCE GONZALES; Fiscal Year: 2010
    ..despite a full understanding of its actions, which has lead to behavioral and mood disorders in women using oral contraceptives. Furthermore, estradiol has recently been associated with a number of neurological disorders including ..
  60. Genetic Variants of Hormone Receptors in Ovarian Cancer
    Kathryn Terry; Fiscal Year: 2003
    ..epidemiologic literature suggests a protective effect for the combination of estrogen and progesterone in oral contraceptives, which are consistently protective...
  61. HORMONAL CONTRACEPTIVES AND INVASIVE CERVICAL CANCER
    Samuel Shapiro; Fiscal Year: 2000
    ..been posited that injectable progestogen-only contraceptives (IPCs) and/or combined estrogen-progestogen oral contraceptives (COCs) may act as cofactors, together with HPV, in the aetiology of cervical cancer...
  62. CASE-CONTROL STUDY OF BREAST CANCER IN YOUNG WOMEN
    Leslie Bernstein; Fiscal Year: 1991
    Although there ius no strong evidence that oral contraceptives (OCs) have an effect on breast cancer risk when used during the middle reproductive years, women who use OCs for long periods of time in the post-menarcheal period may be at ..
  63. Effect of Estrogen on Radiation-induced Cataractogenesis
    JOSEPH DYNLACHT; Fiscal Year: 2005
    ..High estrogen levels are artificially induced in nonpregnant women using oral contraceptives, or in post-menopausal women on estrogen replacement therapy, and these groups may be at an increased risk ..
  64. HORMONAL REPLACEMENT THERAPY AND RISK OF COLON CANCER
    Jean Paul Collet; Fiscal Year: 1999
    ..Also obtained from the SPDP for this same time period will be prescription information on oral contraceptives and NSAIDs...