neuromuscular nondepolarizing agents

Summary

Summary: Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.

Top Publications

  1. ncbi The prevention of pain from injection of rocuronium by magnesium sulphate, lignocaine, sodium bicarbonate and alfentanil
    A Turan
    Departments of Anaesthesiology and Biostatistics, Medical Faculty, Trakya University, Edirne, Turkey
    Anaesth Intensive Care 31:277-81. 2003
  2. ncbi Effective reversal of moderate rocuronium- or vecuronium-induced neuromuscular block with sugammadex, a selective relaxant binding agent
    Koen Suy
    Department of Anesthesiology and Critical Care Medicine, Onze Lieve Vrouw Ziekenhuis, Belgium
    Anesthesiology 106:283-8. 2007
  3. pmc Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function
    Matthias Eikermann
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Anesthesiology 107:621-9. 2007
  4. pmc Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study
    Martina Grosse-Sundrup
    Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    BMJ 345:e6329. 2012
  5. ncbi Neuromuscular pharmacodynamics of rocuronium in patients with major burns
    TaeHyung Han
    Department of Anesthesiology and Pain Medicine, Hangang Sacred Heart Hospital, Hallym University School of Medicine, 94 200 YongDungPo Dong, YongDungPo Ku, Seoul, Korea 150 719
    Anesth Analg 99:386-92, table of contents. 2004
  6. ncbi Postoperative residual block after intermediate-acting neuromuscular blocking drugs
    A H Hayes
    Department of Anaesthetics and Intensive Care Medicine, The Queen's University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Anaesthesia 56:312-8. 2001
  7. ncbi A randomized, dose-finding, phase II study of the selective relaxant binding drug, Sugammadex, capable of safely reversing profound rocuronium-induced neuromuscular block
    Scott B Groudine
    Department of Anesthesiology, Albany Medical Center, Albany, New York 12208 34798, USA
    Anesth Analg 104:555-62. 2007
  8. ncbi Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: a dose-finding and safety study
    Iben F Sorgenfrei
    Department of Anaesthesia and Intensive Care, Copenhagen University Hospital, Rigshospitalet, Denmark
    Anesthesiology 104:667-74. 2006
  9. ncbi The incidence and mechanisms of pharyngeal and upper esophageal dysfunction in partially paralyzed humans: pharyngeal videoradiography and simultaneous manometry after atracurium
    E Sundman
    Department of Anesthesiology, Karolinska Hospital and Institute, Stockholm, Sweden
    Anesthesiology 92:977-84. 2000
  10. ncbi The potency of new muscle relaxants on recombinant muscle-type acetylcholine receptors
    Matthias Paul
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0542, USA
    Anesth Analg 94:597-603; table of contents. 2002

Detail Information

Publications212 found, 100 shown here

  1. ncbi The prevention of pain from injection of rocuronium by magnesium sulphate, lignocaine, sodium bicarbonate and alfentanil
    A Turan
    Departments of Anaesthesiology and Biostatistics, Medical Faculty, Trakya University, Edirne, Turkey
    Anaesth Intensive Care 31:277-81. 2003
    ..Of these drugs, magnesium sulphate, lignocaine and sodium bicarbonate were the most effective while alfentanil was the least effective...
  2. ncbi Effective reversal of moderate rocuronium- or vecuronium-induced neuromuscular block with sugammadex, a selective relaxant binding agent
    Koen Suy
    Department of Anesthesiology and Critical Care Medicine, Onze Lieve Vrouw Ziekenhuis, Belgium
    Anesthesiology 106:283-8. 2007
    ..A secondary objective was to investigate the safety of single doses of sugammadex...
  3. pmc Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function
    Matthias Eikermann
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Anesthesiology 107:621-9. 2007
    ..The authors hypothesized that cholinesterase inhibition when given the in absence of neuromuscular blockade (NB) would decrease upper airway dilatory muscle activity and consequently upper airway volume...
  4. pmc Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study
    Martina Grosse-Sundrup
    Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    BMJ 345:e6329. 2012
    ..To determine whether use of intermediate acting neuromuscular blocking agents during general anesthesia increases the incidence of postoperative respiratory complications...
  5. ncbi Neuromuscular pharmacodynamics of rocuronium in patients with major burns
    TaeHyung Han
    Department of Anesthesiology and Pain Medicine, Hangang Sacred Heart Hospital, Hallym University School of Medicine, 94 200 YongDungPo Dong, YongDungPo Ku, Seoul, Korea 150 719
    Anesth Analg 99:386-92, table of contents. 2004
    ..Resistance to the neuromuscular effects of rocuronium was partially overcome by increasing the dose. A dose up to 1.2 mg/kg provides good tracheal intubating conditions after major burns...
  6. ncbi Postoperative residual block after intermediate-acting neuromuscular blocking drugs
    A H Hayes
    Department of Anaesthetics and Intensive Care Medicine, The Queen's University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Anaesthesia 56:312-8. 2001
    ..Although the residual block is relatively short lasting, it may occasionally be prolonged, requiring close observation and monitoring of such patients in the recovery ward...
  7. ncbi A randomized, dose-finding, phase II study of the selective relaxant binding drug, Sugammadex, capable of safely reversing profound rocuronium-induced neuromuscular block
    Scott B Groudine
    Department of Anesthesiology, Albany Medical Center, Albany, New York 12208 34798, USA
    Anesth Analg 104:555-62. 2007
    ..Sugammadex, a modified gamma-cyclodextrin, encapsulates steroidal neuromuscular blocking drugs, promoting their rapid dissociation from nicotinic receptors. Sugammadex is the first drug that acts as a selective relaxant binding agent...
  8. ncbi Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: a dose-finding and safety study
    Iben F Sorgenfrei
    Department of Anaesthesia and Intensive Care, Copenhagen University Hospital, Rigshospitalet, Denmark
    Anesthesiology 104:667-74. 2006
    ..This study investigated the dose-response relation, safety, and pharmacokinetics of sugammadex to reverse rocuronium-induced block...
  9. ncbi The incidence and mechanisms of pharyngeal and upper esophageal dysfunction in partially paralyzed humans: pharyngeal videoradiography and simultaneous manometry after atracurium
    E Sundman
    Department of Anesthesiology, Karolinska Hospital and Institute, Stockholm, Sweden
    Anesthesiology 92:977-84. 2000
    ..The secondary objective was to evaluate the effect of atracurium on pharyngeal function...
  10. ncbi The potency of new muscle relaxants on recombinant muscle-type acetylcholine receptors
    Matthias Paul
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0542, USA
    Anesth Analg 94:597-603; table of contents. 2002
    ..Different drug-receptor affinities of the tested NDMRs contribute to the differences in clinical dose requirements of these drugs needed to achieve appropriate muscle relaxation...
  11. ncbi Residual paralysis in the PACU after a single intubating dose of nondepolarizing muscle relaxant with an intermediate duration of action
    Bertrand Debaene
    Department of Anesthesia and Intensive Care, Hopital Jean Bernard, Poitiers, France
    Anesthesiology 98:1042-8. 2003
    ....
  12. ncbi Antagonism of non-depolarising neuromuscular block: current practice
    A F Kopman
    Department of Anesthesiology, Weill Cornell Medical College, New York City, NY, USA
    Anaesthesia 64:22-30. 2009
    ..If only a single twitch or none at all can be evoked, neostigmine should not be expected to promptly reverse neuromuscular block, and antagonism is best delayed till a train-of-four-count of two is achieved...
  13. ncbi Rocuronium vs. succinylcholine in the emergency department: a critical appraisal
    William K Mallon
    Department of Emergency Medicine, Los Angeles County University of Southern California Medical Center, Los Angeles, California, USA
    J Emerg Med 37:183-8. 2009
    ..Non-depolarizing drugs have the advantage of causing less pain due to post-paralysis myalgias...
  14. ncbi Residual neuromuscular blockade and critical respiratory events in the postanesthesia care unit
    Glenn S Murphy
    Department of Anesthesiology, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Anesth Analg 107:130-7. 2008
    ..The aim of this investigation was to assess and quantify the severity of neuromuscular blockade in patients with signs or symptoms of critical respiratory events (CREs) in the PACU...
  15. pmc Potency of nondepolarizing muscle relaxants on muscle-type acetylcholine receptors in denervated mouse skeletal muscle
    Hong Wang
    Department of Anesthesiology, First People s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China
    Acta Pharmacol Sin 31:1541-6. 2010
    ..to investigate the changing resistance to nondepolarizing muscle relaxants (NDMRs) during the first month after denervation...
  16. ncbi The prevention of pain from injection of rocuronium by ondansetron, lidocaine, tramadol, and fentanyl
    Dilek Memis
    Department of Anaesthesiology, Medical Facility, Trakya University, 22030 Edirne, Turkey
    Anesth Analg 94:1517-20, table of contents. 2002
    ..001). We conclude that ondansetron, lidocaine, tramadol, and fentanyl decrease the level of rocuronium injection pain. Among these drugs, lidocaine is the most effective, whereas fentanyl is the least effective...
  17. ncbi Reversal of profound rocuronium-induced blockade with sugammadex: a randomized comparison with neostigmine
    R Kevin Jones
    Accurate Clinical Trials Saddleback Memorial Medical Center, Laguna Hills, CA 92653, USA
    Anesthesiology 109:816-24. 2008
    ..Sugammadex is a novel reversal agent, reversing the effects of rocuronium by encapsulation. This study assessed the efficacy and safety of sugammadex versus neostigmine for reversal of profound rocuronium-induced neuromuscular blockade...
  18. ncbi Interaction of d-tubocurarine analogs with mutant 5-HT(3) receptors
    Dong Yan
    Drexel University College of Medicine, Department of Pharmacology and Physiology, 245 N 15th Street, Philadelphia PA, 19102 1192 USA
    Neuropharmacology 43:367-73. 2002
    ..Rather, these two residues are likely to play a role in determining both the geometry of the binding site, as well as the overall environment that a ligand encounters in the binding site...
  19. ncbi Curariform antagonists bind in different orientations to the nicotinic receptor ligand binding domain
    Hai Long Wang
    Receptor Biology Laboratory, Department of Physiology and Biophysics, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 278:32284-91. 2003
    ..The overall mutagenesis and computational results show that despite their similar structures, d-TC and metocurine bind in distinctly different orientations to the adult human AChR...
  20. ncbi Rocuronium-induced generalized spontaneous movements cause pulmonary aspiration
    Jiin Tarng Lui
    Department of Anesthesia, Chang Gung Memorial Hospital, Taipei, ROC
    Chang Gung Med J 25:617-20. 2002
    ..We describe a case of gastric regurgitation with pulmonary aspiration following generalized spontaneous movements associated with rocuronium injection in a girl who received pediatric emergent surgery...
  21. ncbi Comparison of four strategies to reduce the pain associated with intravenous administration of rocuronium
    A B Chiarella
    Department of Anesthesiology and Pain Medicine, 3B2 32 Walter C Mackenzie Health Sciences Centre, University of Alberta Hospitals, 8440 112 Street, Edmonton, Alberta, Canada T6G 2B7
    Br J Anaesth 90:377-9. 2003
    ..I.V. rocuronium produces intense discomfort at the site of injection in conscious patients. Four strategies to reduce or prevent this discomfort were studied...
  22. ncbi A comparison of succinylcholine and rocuronium for rapid-sequence intubation of emergency department patients
    E G Laurin
    Division of Emergency Medicine, University of California, Davis, Medical Center, University of California, Davis, School of Medicine, Sacramento, CA, USA
    Acad Emerg Med 7:1362-9. 2000
    ..To compare rocuronium and succinylcholine for rapid-sequence intubation (RSI) in the emergency department (ED)...
  23. ncbi Impact of the intubation model on the efficacy of rocuronium during rapid sequence intubation: systematic review of randomized trials
    C Lysakowski
    Division of Anaesthesiology, University Hospitals of Geneva, Geneva, Switzerland
    Acta Anaesthesiol Scand 51:848-57. 2007
    ..Propofol-rocuronium is thought to be superior to thiopental-rocuronium for rapid sequence intubation (RSI). The role of the intubation model per se has never been investigated...
  24. ncbi Distinct pharmacologic properties of neuromuscular blocking agents on human neuronal nicotinic acetylcholine receptors: a possible explanation for the train-of-four fade
    Malin Jonsson
    Department of Anesthesiology and Intensive Care Medicine, Karolinska University Hospital and Karolinska Institutet, Sweden
    Anesthesiology 105:521-33. 2006
    ..The aim of this study was to examine the effect of clinically used nondepolarizing NMBAs on muscle and neuronal nAChR subtypes...
  25. ncbi A mechanism for rapacuronium-induced bronchospasm: M2 muscarinic receptor antagonism
    Edmund Jooste
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P and S Box 46, New York, New York 10032, USA
    Anesthesiology 98:906-11. 2003
    ..g., intubation) can result in the massive release of acetylcholine to act on unopposed M3 muscarinic receptors in airway smooth muscle, thereby facilitating bronchoconstriction...
  26. ncbi Injection pain of rocuronium and vecuronium is evoked by direct activation of nociceptive nerve endings
    J A Blunk
    Friedrich Alexander University, Department of Anaesthesiology, Erlangen, Germany
    Eur J Anaesthesiol 20:245-53. 2003
    ..Dermal microdialysis in human and electrophysiological recordings of nociceptors in mouse skin were used to elucidate the underlying mechanisms of pain induction...
  27. ncbi Spontaneous movements, local reactions and pain on injection of rocuronium. A comparison between female and male patients
    T Mencke
    Department of Anaesthesia and Critical Care, University of the Saarland, Homburg/Saar, Germany
    Acta Anaesthesiol Scand 45:1002-5. 2001
    ..This was not associated with adverse clinical consequences for the patient's outcome...
  28. ncbi Rapacuronium augments acetylcholine-induced bronchoconstriction via positive allosteric interactions at the M3 muscarinic receptor
    Edmund H Jooste
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Anesthesiology 103:1195-203. 2005
    ..Despite its withdrawal from clinical use, it is imperative that the mechanism by which bronchospasm occurred is understood so that new muscle relaxants introduced to clinical practice do not share these same detrimental airway effects...
  29. ncbi Preventing the withdrawal response associated with rocuronium injection: a comparison of fentanyl with lidocaine
    Norezalee Ahmad
    Clinical Anesthesiology Specialist, Hospital Sultanah Aminah, Johor Bahru, Malaysia
    Anesth Analg 100:987-90. 2005
    ..05). In conclusion, both fentanyl and lidocaine are effective clinical treatments to alleviate the withdrawal response associated with rocuronium injection, with fentanyl being more effective...
  30. ncbi Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor
    Malin Jonsson Fagerlund
    Department of Anesthesiology and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden
    Anesthesiology 110:1244-52. 2009
    ..The aim of this study was to investigate the effect of clinically used nondepolarizing NMBAs at human adult muscle nAChRs and the mechanisms behind the inhibition...
  31. ncbi The effect of local anesthetics on the inhibition of adult muscle-type nicotinic acetylcholine receptors by nondepolarizing muscle relaxants
    Hong Wang
    Department of Anesthesiology, First People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Eur J Pharmacol 630:29-33. 2010
    ....
  32. ncbi Rocuronium versus succinylcholine for rapid sequence induction of anesthesia and endotracheal intubation: a prospective, randomized trial in emergent cases
    Mathias Sluga
    Department of Anesthesia, Krankenhaus Thusis, Switzerland
    Anesth Analg 101:1356-61. 2005
    ..We conclude that during rapid sequence induction of anesthesia in emergent cases, succinylcholine allows for a more rapid endotracheal intubation sequence and creates superior intubation conditions compared with rocuronium...
  33. ncbi Prolonged relaxant effects of vecuronium in patients with deliberate hypermagnesemia: time for caution in cesarean section
    Akiko Yoshida
    Department of Anesthesiology, Tohoku University Hospital, Sendai, Japan
    J Anesth 20:33-5. 2006
    ..Our cases underscore the need for anesthesiologists as well as obstetricians to be aware of the prolongation of the action of nondepolarizing muscle relaxants as a result of magnesium treatment...
  34. ncbi Sepsis stage dependently and differentially attenuates the effects of nondepolarizing neuromuscular blockers on the rat diaphragm in vitro
    Eichi Narimatsu
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Anesth Analg 100:823-9, table of contents. 2005
    ..The results indicate that sepsis induces hyposensitivities to nondepolarizing neuromuscular blockers, the degree of which depends on the stage of sepsis and on the kind of neuromuscular blocker...
  35. ncbi Role of muscle relaxants in pediatric anesthesia
    George H Meakin
    Department of Anaesthesia, Royal Manchester Children s Hospital, Pendlebury, Manchester, UK
    Curr Opin Anaesthesiol 20:227-31. 2007
    ..This article reviews these developments, and defines the current role and factors affecting the choice of muscle relaxant drugs in pediatric anesthesia...
  36. ncbi A comparison of the effect of two anaesthetic techniques on surgical conditions during gynaecological laparoscopy
    M T Williams
    Queen Alexandra Hospital, Portsmouth, Hampshire, UK
    Anaesthesia 58:574-8. 2003
    ..However surgeons should be aware of the different abdominal pressure patterns produced by each anaesthetic technique, and anaesthetists must consider the implications of the anaesthetic technique on surgical safety...
  37. ncbi Organophosphate-induced intermediate syndrome: aetiology and relationships with myopathy
    Lakshman Karalliedde
    Chemical Hazards and Poisons Division London, Health Protection Agency, London, UK
    Toxicol Rev 25:1-14. 2006
    ..This has led to speculation that myopathy is involved in the causation of the IMS. However, while myopathy and the IMS have a common origin in acetylcholine accumulation, they are not causally related to one another...
  38. ncbi Fade of pulmonary function during residual neuromuscular blockade
    Matthias Eikermann
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Hufelandstr 55, D 45122 Essen, Germany
    Chest 127:1703-9. 2005
    ..We tested the hypothesis that fade of pulmonary function, ie, a decrease in values of FVC with the second spirometric maneuver compared to the first maneuver, occurs during impaired neuromuscular transmission...
  39. ncbi Early reversal of profound rocuronium-induced neuromuscular blockade by sugammadex in a randomized multicenter study: efficacy, safety, and pharmacokinetics
    Harald J Sparr
    Department of Anesthesiology and Critical Care Medicine, Medical University Innsbruck, Innsbruck, Austria
    Anesthesiology 106:935-43. 2007
    ..Sugammadex reverses the neuromuscular blocking effects of rocuronium by chemical encapsulation. The efficacy, safety, and pharmacokinetics of sugammadex for reversal of profound rocuronium-induced neuromuscular blockade were evaluated...
  40. pmc Sugammadex compared with neostigmine/glycopyrrolate for routine reversal of neuromuscular block: a systematic review and economic evaluation
    F Paton
    Centre for Reviews and Dissemination, University of York, Heslington, York YO10 5DD, UK
    Br J Anaesth 105:558-67. 2010
    ..Further research is required to evaluate the effects of sugammadex on patient safety, predictability of recovery from NMB, patient outcomes, and efficient use of resources...
  41. ncbi Neostigmine/glycopyrrolate administered after recovery from neuromuscular block increases upper airway collapsibility by decreasing genioglossus muscle activity in response to negative pharyngeal pressure
    Frank Herbstreit
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Essen, Germany
    Anesthesiology 113:1280-8. 2010
    ..However, neostigmine may also impair muscle strength. We hypothesized that neostigmine administered after recovery of the train-of-four (TOF) ratio impairs upper airway integrity and genioglossus muscle function...
  42. ncbi The role of loop F residues in determining differential d-tubocurarine potencies in mouse and human 5-hydroxytryptamine 3A receptors
    Ran Zhang
    Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, 3601 Fourth Street, Lubbock, Texas 79430, USA
    Biochemistry 46:1194-204. 2007
    ..8 +/- 6.38 nM) as that of the human receptor containing all six loop F mouse substitutions. These results demonstrate that two loop F residues make a significant contribution in determining curare potency at the 5-HT3A receptor...
  43. pmc Succinylcholine versus rocuronium for rapid sequence intubation in intensive care: a prospective, randomized controlled trial
    Stephan C Marsch
    Department of Medical Intensive Care, University Hospital Basel, University of Basel, Petersgraben 4, Basel 4031, Switzerland
    Crit Care 15:R199. 2011
    ..Accordingly, the aim of the present study was to compare the incidence of hypoxemia after rocuronium or succinylcholine in critically ill patients requiring an emergent RSI...
  44. ncbi Additive inhibition of nicotinic acetylcholine receptors by corticosteroids and the neuromuscular blocking drug vecuronium
    C H Kindler
    Department of Anesthesia, University of California, San Francisco 94143 0542, USA
    Anesthesiology 92:821-32. 2000
    ....
  45. pmc Different magnitude of resistance to nondepolarizing muscle relaxants in the denervated mouse skeletal muscle
    Hong Wang
    Department of Anesthesiology, First People s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China
    Acta Pharmacol Sin 31:399-404. 2010
    ..To test the hypothesis that different magnitude of resistance of denervated skeletal muscle to nondepolarizing muscle relaxants (NDMRs) is related to their varying potencies at epsilon-AChR and gamma-AChR...
  46. ncbi A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host
    Anton Bom
    Department of Medicinal Chemistry, Newhouse ML1 5SH, Scotland, UK
    Angew Chem Int Ed Engl 41:266-70. 2002
  47. ncbi Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing
    M Eikermann
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Br J Anaesth 101:344-9. 2008
    ..Sugammadex reverses neuromuscular block by encapsulating rocuronium. However, its effects on upper airway integrity and breathing are unknown...
  48. ncbi Reversal of neuromuscular blockade and simultaneous increase in plasma rocuronium concentration after the intravenous infusion of the novel reversal agent Org 25969
    Ola Epemolu
    Department of Pharmacology, Organon Research, Scotland, United Kingdom
    Anesthesiology 99:632-7; discussion 6A. 2003
    ....
  49. ncbi Optimal rocuronium dose for intubation during inhalation induction with sevoflurane in children
    M Eikermann
    Abteilung für Anästhesiologie und Intensivmedizin, Universitat Essen, Hufelandstr 55, D 45122 Essen, Germany
    Br J Anaesth 89:277-81. 2002
    ....
  50. ncbi The influence of halothane, isoflurane and sevoflurane on rocuronium infusion in children
    B Woloszczuk-Gebicka
    Department of Anaesthesiology and Intensive Therapy, Memorial Children s Health Institute, Warsaw, Poland
    Acta Anaesthesiol Scand 45:73-7. 2001
    ..This study was designed to determine the infusion requirements in children under nitrous oxide and fentanyl, halothane, isoflurane or sevoflurane anaesthesia...
  51. ncbi Neuromuscular blocking effects of rocuronium during desflurane, isoflurane, and sevoflurane anaesthesia
    H Wulf
    Department of Anaesthesiology and Intensive Care, Hospital of the Christian Albrechts University, Kiel, Germany
    Can J Anaesth 45:526-32. 1998
    ..To determine the magnitude of the potentiation of rocuronium by desflurane, isoflurane and sevoflurane 1.5 MAC anaesthesia...
  52. ncbi Multicentre, parallel-group, comparative trial evaluating the efficacy and safety of sugammadex in patients with end-stage renal failure or normal renal function
    L M Staals
    Department of Anaesthesiology, Pain and Palliative Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Br J Anaesth 101:492-7. 2008
    ..As sugammadex is primarily cleared renally, this phase III trial investigated the efficacy and safety of sugammadex for reversal of rocuronium-induced neuromuscular block (NMB) in patients with end-stage renal failure...
  53. ncbi Pharmacodynamics of rocuronium 0.3 mg kg(-1) in adult patients with and without renal failure
    E N Robertson
    Radboud University, Department of Anesthesia, Nijmegen, The Netherlands
    Eur J Anaesthesiol 22:929-32. 2005
    ..The present study aims to describe the neuromuscular effects of 0.3 mg kg(-1) rocuronium under propofol anaesthesia in patients with renal failure and to compare these effects with healthy control patients...
  54. ncbi Org 25969 (sugammadex), a selective relaxant binding agent for antagonism of prolonged rocuronium-induced neuromuscular block
    M Shields
    Department of Anaesthetics and Intensive Care Medicine, Queen s University of Belfast, Northern Ireland, UK
    Br J Anaesth 96:36-43. 2006
    ..The aim of this study was to explore the efficacy, dose-response relation and safety of Org 25969 for reversal of a prolonged rocuronium-induced neuromuscular block...
  55. ncbi The effect of ephedrine on intubating conditions and haemodynamics during rapid tracheal intubation using propofol and rocuronium
    M D Gopalakrishna
    Department of Anaesthesiology, Kasturba Medical College, Manipal 576104, India
    Br J Anaesth 99:191-4. 2007
    ..We compared the effect of pre-treatment with ephedrine 75, 100, 150 microg kg(-1) and saline on intubating conditions and haemodynamics during rapid tracheal intubation using propofol and rocuronium...
  56. ncbi Cisatracurium vs. Rocuronium: A prospective, comparative, randomized study in adult patients under total intravenous anaesthesia
    Milan Adamus
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital and Faculty of Medicine, Palacky University, Olomouc, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 150:333-8. 2006
    ..To compare the pharmacodynamics of cisatracurium and rocuronium-induced neuromuscular block following single dose, allowing either spontaneous or neostigmine-accelerated complete recovery...
  57. ncbi Xenon does not modify mivacurium induced neuromuscular block
    Oliver Kunitz
    Department of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Can J Anaesth 52:940-3. 2005
    ..The interaction between mivacurium and inhaled anesthetics is known, with the exception of xenon. We compared the pharmacodynamics of mivacurium during xenon anesthesia vs total iv anesthesia with propofol...
  58. ncbi Decrease in functional residual capacity and ventilation homogeneity after neuromuscular blockade in anesthetized preschool children in the lateral position
    Britta S von Ungern-Sternberg
    Division of Anesthesia, University Children s Hospital, Basel, Switzerland
    Paediatr Anaesth 17:841-5. 2007
    ....
  59. ncbi Tracheal intubation in routine practice with and without muscular relaxation: an observational study
    C Baillard
    Hopital Avicenne, APHP, Département d Anesthésie Réanimation and SAMU 93 EA 3409, Bobigny Cedex, France
    Eur J Anaesthesiol 22:672-7. 2005
    ..There remains controversy as to whether or not a muscle relaxant is routinely required for tracheal intubation. This study examined conditions of intubation in our routine practice, which employs a relaxant-sparing approach...
  60. ncbi Fast-track method in cardiac surgery: evaluation of risks and benefits of continuous administration technique
    M Najafi
    Tehran Heart Center, Faculty of Medical Sciences, University of Tehran, North Kargar Avenue, Tehran 14117 13138, Iran
    Singapore Med J 49:470-5. 2008
    ..This study was carried out to assess the risks and benefits of conducting the fast-track method in cardiac anaesthesia and to evaluate the role of continuous infusion of short-acting anaesthetics in a successful fast-track protocol...
  61. ncbi Use of BIS monitor during anaesthesia of a narcoleptic patient for avoiding possible delayed emergence
    Z Ozkose
    Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Ankara Turkey
    Acta Anaesthesiol Belg 58:59-61. 2007
    ..The aim of presenting this case report is to emphasize the importance of BIS monitor use in a narcoleptic patient undergoing surgery under general anaesthesia to avoid possible prolonged emergence...
  62. ncbi [The incidence of postoperative residual curarization in the recovery room after rocuronium administration]
    M Adamus
    Klinika anesteziologie a resuscitace, Fakultní nemocnice a lékarská fakulta Univerzity Palackého, Olomouc
    Rozhl Chir 86:11-6. 2007
    ..26 (0.47) mg vs. 0.57 (0.71) mg, p < 0.01]. We conclude that it is necessary to antagonize residual block after rocuronium, especially in the absence of perioperative neuromuscular monitoring...
  63. ncbi Lightwand tracheal intubation with and without muscle relaxation
    Eva Massó
    Department of Anesthesiology, Hospital Universitari Germans Trias i Pujol, Carretera de Canyet s n, 08916 Badalona, Spain
    Anesthesiology 104:249-54. 2006
    ....
  64. ncbi Reversal of rocuronium-induced neuromuscular block with the novel drug sugammadex is equally effective under maintenance anesthesia with propofol or sevoflurane
    Bernard F Vanacker
    Department of Anesthesiology, University Hospitals Leuven, KU Leuven, Leuven, Belgium
    Anesth Analg 104:563-8. 2007
    ..There were no treatment-related serious adverse events and no discontinuations or deaths. No residual paralysis occurred. The safety profile of sugammadex was somewhat more favorable under propofol than under sevoflurane anesthesia...
  65. ncbi Cisatracurium or rocuronium versus rocuronium-cisatracurium combination
    Ahed Zeidan
    Department of Anaesthesiology, Sahel General Hospital, Beirut, Lebanon
    Middle East J Anaesthesiol 18:879-86. 2006
    ..However, the combination of 1ED95 cisatracurium with 1ED95 rocuronium provided similar intubating conditions to the 2ED95 rocuronium alone, associated with a significantly less pain on injection...
  66. ncbi The role of magnesium as an adjuvant during general anaesthesia
    K Gupta
    Department of Anaesthesiology, Pain and Perioperative Medicine, Sir Ganga Ram Hospital, Old Rajinder Nagar, New Delhi, India
    Anaesthesia 61:1058-63. 2006
    ..We concluded that magnesium sulphate has anaesthetic, analgesic and muscle relaxation effects and significantly reduces the drug requirements of propofol, rocuronium and fentanyl during anaesthesia...
  67. ncbi Reversal of rocuronium with edrophonium during propofol versus sevoflurane anesthesia
    T J Zhou
    Department of Anesthesiology and Pain Management, University of Texas, Southwestern Medical Center at Dallas, 75239-9068, USA
    Acta Anaesthesiol Scand 45:246-9. 2001
    ..6 mg kg(-1) i.v., was similar during both propofol- and sevoflurane-based anesthesia. However, the reversal of rocuronium-induced residual blockade was slower and more variable in the presence of sevoflurane...
  68. ncbi [Neuromuscular blocking effects of Org 9426 (rocuronium bromide); a comparative study with vecuronium bromide in Japanese patients]
    Koh Shingu
    Department of Anesthesiology, Kansai Medical University, Moriguchi
    Masui 55:1140-8. 2006
    ..Efficacy and safety of Org 9426 were compared with those of vecuronium bromide in Japanese patients...
  69. ncbi The effect of desflurane on rocuronium onset, clinical duration and maintenance requirements
    R G Stout
    Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06520 8051, USA
    Acta Anaesthesiol Belg 57:349-53. 2006
    ..003). Recovery times were not statistically different. Desflurane significantly delays the onset of neuromuscular block, potentiates rocuronium during maintenance infusion, but does not affect clinical duration or recovery...
  70. ncbi Skin reactions to intradermal neuromuscular blocking agent injections: a randomized multicenter trial in healthy volunteers
    Paul Michel Mertes
    Department of Anesthesiology, Service d Anesthesie Reanimation, Hopital Central, Centre Hospitalier Universitaire de Nancy, Unité Inserm 684, Faculte de Medecine de Nancy, France
    Anesthesiology 107:245-52. 2007
    ..Numerous reports confirm the performance of intradermal tests for the diagnosis of anaphylaxis during anesthesia; however, there is controversy over their diagnostic value regarding the newer neuromuscular blocking agents (NMBAs)...
  71. ncbi A comparison of intubation conditions and time-course of action with rocuronium and mivacurium for day case anaesthesia
    P E Pendeville
    Department of Anaesthesiology, Cliniques Universitaires Saint Luc, UCL Medical School, Avenue Hippocrate 10 1821, 1200 Brussels, Belgium
    Eur J Anaesthesiol 24:546-50. 2007
    ..To compare intubation conditions and time-course of action of rocuronium and mivacurium for day case anaesthesia...
  72. ncbi Consensus guidelines for sustained neuromuscular blockade in critically ill children
    Stephen Playfor
    Paediatric Intensive Care Unit, Royal Manchester Children s Hospital, Pendlebury, Manchester, UK
    Paediatr Anaesth 17:881-7. 2007
    ..However, similar clinical practice guidelines have not previously been produced for the critically ill pediatric patient...
  73. ncbi Rocuronium 0.3 mg x kg-1 (ED95) induces a normal peak effect but an altered time course of neuromuscular block in patients with Duchenne's muscular dystrophy
    Tino Muenster
    Department of Anaesthesiology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Paediatr Anaesth 16:840-5. 2006
    ..It has been assumed that this is because of a higher potency of muscle relaxants in this patient cohort. We determined the peak effect, and the time course of action of rocuronium 0.3 mg x kg(-1) (ED(95)) in DMD patients...
  74. ncbi [Influence of neostigmine on the course of neuromuscular blockade with rocuronium or cisatracurium: a randomized, double-blind trial]
    J Barrio
    Servicio de Anestesiologia, Hospital Arnau de Vilanova, Valencia
    Rev Esp Anestesiol Reanim 54:399-404. 2007
    ..To compare the time-course of neuromuscular blockade with rocuronium or cisatracurium during intravenous anesthesia, in terms of both the time to spontaneous recovery or time to reversal after administration of neostigmine...
  75. ncbi [Randomized, multicenter study of interaction between Org 9426 (rocuronium bromide) and anesthetic agents in Japanese population]
    Yoshifumi Kotake
    Department of Anesthesiology, School of Medicine, Keio University, Tokyo 160 8582
    Masui 55:873-9. 2006
    ....
  76. ncbi Hepatotoxicity after desflurane anesthesia in a 15-month-old child with Mobius syndrome after previous exposure to isoflurane
    Geneviève Côté
    Department of Anesthesiology, Centre hospitalier universitaire Sainte Justine, 3175 chemin de la Cote Sainte Catherine, Montreal, Quebec, Canada, H3T 1C5
    Anesthesiology 107:843-5. 2007
  77. ncbi [Influence of neuromuscular blockade on the airway leak pressure of the ProSeal laryngeal mask airway]
    K Goldmann
    Klinik für Anästhesie und Intensivtherapie, Philipps Universitat Marburg
    Anasthesiol Intensivmed Notfallmed Schmerzther 41:228-32. 2006
    ..With this study we tested the hypothesis that a neuromuscular blockade can result in a decreased P (leak) of the PLMA...
  78. ncbi Safety and tolerability of single intravenous doses of sugammadex administered simultaneously with rocuronium or vecuronium in healthy volunteers
    G Cammu
    Department of Anaesthesiology and Critical Care Medicine, Onze Lieve Vrouw Clinic, Moorselbaan 164, 9300 Aalst, Belgium
    Br J Anaesth 100:373-9. 2008
    ..v. doses of sugammadex administered simultaneously with rocuronium or vecuronium to anaesthetized and non-anaesthetized healthy volunteers...
  79. doi Clinical use of xenon in 2 elderly patients
    Davide Cattano
    J Neurosurg Anesthesiol 20:156-8. 2008
  80. ncbi Reversal of rocuronium-induced neuromuscular block with sugammadex is faster than reversal of cisatracurium-induced block with neostigmine
    E A Flockton
    University Department of Anaesthesia, School of Clinical Sciences, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    Br J Anaesth 100:622-30. 2008
    ..The safety of sugammadex and neostigmine was also evaluated...
  81. ncbi Incidence and duration of residual paralysis at the end of surgery after multiple administrations of cisatracurium and rocuronium
    D M Maybauer
    Klinik für Anästhesiologie und Intensivmedizin, Philipps Universitat Marburg, Germany
    Anaesthesia 62:12-7. 2007
    ....
  82. ncbi [Monitoring of consciousness with BIS during induction of anesthesia. Which muscle relaxant?]
    S Gazzanelli
    Dipartimento di Scienze Anestesiologiche, Medicina Critica e Terapia del Dolore, Universita degli Studi La Sapienza, Roma
    G Chir 26:163-9. 2005
    ..The BIS-index data show that an opiate as Fentanyl is advisable with associations Cisatracurium/Propofol or Vecuronium/Propofol. It is possible to use in these cases a drip infusion to avoid the risk of awareness during intubation...
  83. ncbi Neuromuscular recovery following rocuronium bromide single dose in infants
    H J Rapp
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Mannheim, Oberschleissheim, Germany
    Paediatr Anaesth 14:329-35. 2004
    ..However, clinical evidence shows a longer duration of recovery in small infants. The aim of this study was to investigate the influence of age on rocuronium recovery during the first year of life...
  84. ncbi Priming rapacuronium: a comparison with rocuronium and mivacurium
    David Steinberg
    Hospital de Clinicas Caracas, Servicio de Anestesiologia, San Bernandino Caracas, Venezuela
    Acta Cient Venez 54:115-20. 2003
    ..Pre-synaptic effect does not explain consistently the mode of action of priming...
  85. ncbi The presence of working memory without explicit recall in a critically ill patient
    Mehmet S Ozcan
    Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida 32610 0254, USA
    Anesth Analg 98:469-70, table of contents. 2004
    ..This experience suggests that working memory demonstrated when BIS values are less than 60 is unlikely to lead to recall...
  86. ncbi Implications of the use of neuromuscular transmission monitoring on immediate postoperative extubation in off-pump coronary artery bypass surgery
    G Cammu
    Department of Anaesthesia and Critical Care Medicine, Onze Lieve Vrouw Clinic, Aalst, Belgium
    Eur J Anaesthesiol 20:884-90. 2003
    ....
  87. ncbi Neuromuscular block and relative concentrations of mivacurium isomers under isoflurane versus propofol anaesthesia
    T Ledowski
    Hospital of the Christian Albrechts University, Department of Anaesthesiology and Intensive Care Medicine, Kiel, Germany
    Eur J Anaesthesiol 20:821-5. 2003
    ..The pharmacological interaction and relative plasma concentrations of mivacurium isomers were investigated during either propofol- or isoflurane-maintained anaesthesia...
  88. ncbi Atracurium, cisatracurium, vecuronium and rocuronium in patients with renal failure
    G Della Rocca
    Department of Anaesthesia, University of Udine, Udine, Italy
    Minerva Anestesiol 69:605-11, 612, 5. 2003
    ....
  89. ncbi Anaesthetic implications of Robinow syndrome
    Philipp Lirk
    Department of Anaesthesiology and Critical Care Medicine, University of Innsbruck, Austria
    Paediatr Anaesth 13:725-7. 2003
    ..We report the anaesthetic management of a patient with Robinow syndrome presenting for elective surgery and review specific issues of interest in the perioperative workup...
  90. ncbi Comparison between the Datex-Ohmeda M-NMT module and a force-displacement transducer for monitoring neuromuscular blockade
    C Motamed
    Hopital Henri Mondor, Service d Anesthesie Reanimation, AP HP et Université Paris XII, Creteil, France
    Eur J Anaesthesiol 20:467-9. 2003
    ..It incorporates a mechanosensor, which is a piezoelectric polymer attached to the hand. The module was compared with a force transducer in 30 patients requiring neuromuscular blockade...
  91. ncbi Risk of recurarization during retransfusion of autologous blood withdrawn after injection of muscle relaxants: a comparison of rocuronium and mivacurium
    R G Rohling
    Institute of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
    J Clin Anesth 15:85-90. 2003
    ..The present study for the first time examined this risk for rocuronium and mivacurium...
  92. ncbi Performance of the rapidly extracted auditory evoked potentials index to detect the recovery and loss of wakefulness in anesthetized and paralyzed patients
    S J Ge
    Department of Anesthesiology, Shanghai First People s Hospital, Shanghai, China
    Acta Anaesthesiol Scand 47:466-71. 2003
    ..A prospective study was designed to assess the performance of AAI to detect the recovery and loss of wakefulness in anesthetized and paralyzed patients...
  93. ncbi Prospective randomised double-blind comparative study of rocuronium and pancuronium in adult patients scheduled for elective 'fast-track' cardiac surgery involving hypothermic cardiopulmonary bypass
    R Thomas
    Shackleton Department of Anaesthetics, Southampton General Hospital, UK
    Anaesthesia 58:265-71. 2003
    ..Unless fast-track patients have neuromuscular function assessed before extubation, pancuronium should not be used...
  94. ncbi Tracheal rupture following endotracheal intubation
    K Stannard
    Department of Anaesthesia and Pain Medicine, Royal Perth Hospital, Wellington Campus, GPO Box X2213, Perth, W A 6847
    Anaesth Intensive Care 31:588-91. 2003
    ..In this case, "side-by-side" microlaryngoscopy tubes, one endobronchial and the other with the tip in the upper trachea, placed with fibreoptic assistance were used for airway management during the tracheal repair...
  95. ncbi Postoperative residual curarization with cisatracurium and rocuronium infusions
    G Cammu
    Ghent University Hospital, Department of Anaesthesia, Belgium
    Eur J Anaesthesiol 19:129-34. 2002
    ..We investigated the recovery characteristics and incidence of postoperative residual curarization after cisatracurium and rocuronium infusions for long duration interventions without systematic antagonism...
  96. ncbi Rocuronium pharmacokinetic-pharmacodynamic relationship under stable propofol or isoflurane anesthesia
    Alexandrina Dragne
    De la Faculté de pharmacie, Universite de Montreal, Montreal, Quebec, Canada
    Can J Anaesth 49:353-60. 2002
    ..To compare the pharmacokinetics, pharmacodynamics and the concentration-effect relationship of rocuronium in patients under stable propofol or isoflurane anesthesia...
  97. ncbi The effect of cisatracurium and rocuronium on cisatracurium precurarization and the priming principle
    Peter H K Mak
    Department of Anaesthesiology, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong, Taiwan ROC
    J Clin Anesth 16:83-7. 2004
    ..To demonstrate the effect of administering a precurarizing dose of cisatracurium or rocuronium on the speed of onset of cisatracurium, and to review the possible mechanisms and value of the priming principle...
  98. ncbi [Neuromuscular rest blockades after a single dose of a mid-term muscle relaxant]
    J U Schreiber
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar
    Anaesthesist 53:1006-8. 2004
  99. ncbi Comparative study of intubating conditions at the first minute with suxamethonium, rocuronium and different priming techniques of rocuronium
    J R Ortiz-Gómez
    University Clinic, Department of Anesthesiology and Intensive Care, Navarra, Spain
    Eur J Anaesthesiol 22:263-8. 2005
    ..To evaluate orotracheal intubation conditions after 1 min...
  100. ncbi Prolonged (more than ten hours) neuromuscular blockade after cardiac surgery: report of two cases
    Lori Olivieri
    Department of Anesthesia, McGill University and McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada
    Can J Anaesth 52:88-93. 2005
    ..We examine two cases of prolonged neuromuscular blockade (NMB) after cardiac surgery. To the best of our knowledge, these are the first reported cases of complete paralysis lasting more than ten hours after surgery...
  101. ncbi Antagonism of profound cisatracurium and rocuronium block: the role of objective assessment of neuromuscular function
    Aaron F Kopman
    Department of Anesthesiology, New York Medical College, Valhalla, NY, USA
    J Clin Anesth 17:30-5. 2005
    ..70), but clinically undetectable (TOF ratio >0.40), residual neuromuscular block after neostigmine antagonism of profound cisatracurium (CIS) or rocuronium (ROC) block...

Research Grants7

  1. HYPOXIC PULMONARY VASOCANSTRICTION AND RED BLOOD CELLS
    Steven Deem; Fiscal Year: 2002
    ....
  2. Exacerbation of Alzheimer's Disease by Nitrous Oxide
    W Kofke; Fiscal Year: 2003
    ..Moreover, observation of a protective effect may result in discovery of an easily implemented preventative drug therapy for AD. ..
  3. ANESHETIC MODULATION OF NATIVE NICOTINIC RECEPTORS
    Pamela Flood; Fiscal Year: 2003
    ..The resulting information will provide understanding of the molecular mechanism underlying one of the anesthetic effects that limit anesthetic safety. ..
  4. Kinetics of Ligand Binding to Synaptic Ion Channels
    JAMES DILGER; Fiscal Year: 2006
    ..4. Use isothermal titration calorimetry to measure the thermodynamics of ligand binding to acetylcholine binding protein - a water soluble protein whose structure is being used as a template for the acetylcholine receptor. ..
  5. Interest of IKr-related Abnormalities of ECGs to Improve Drug-safety Evaluation
    Jean Philippe Couderc; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. Red Blood Cells, Nitric Oxide and Pulmonary Circulation
    Steven Deem; Fiscal Year: 2008
    ..abstract_text> ..
  7. Activity-Dependent Gene Expression in Human Epilepsy
    Jeffrey A Loeb; Fiscal Year: 2010
    ..abstract_text> ..