neuromuscular blocking agents

Summary

Summary: Drugs that interrupt transmission of nerve impulses at the skeletal neuromuscular junction. They can be of two types, competitive, stabilizing blockers (NEUROMUSCULAR NONDEPOLARIZING AGENTS) or noncompetitive, depolarizing agents (NEUROMUSCULAR DEPOLARIZING AGENTS). Both prevent acetylcholine from triggering the muscle contraction and they are used as anesthesia adjuvants, as relaxants during electroshock, in convulsive states, etc.

Top Publications

  1. ncbi [Monitoring of consciousness with BIS during induction of anesthesia. Which muscle relaxant?]
    S Gazzanelli
    Dipartimento di Scienze Anestesiologiche, Medicina Critica e Terapia del Dolore, Universita degli Studi La Sapienza, Roma
    G Chir 26:163-9. 2005
  2. ncbi Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision
    T Fuchs-Buder
    Department of Anaesthesiology and Intensive Care Medicine, University of Nancy, France
    Acta Anaesthesiol Scand 51:789-808. 2007
  3. ncbi Tracheal intubation without the use of neuromuscular blocking agents
    A W Woods
    Stirling Royal Infirmary, Stirling and Anaesthetic Department, Western Infirmary and Gartnavel General Hospital, Glasgow, UK
    Br J Anaesth 94:150-8. 2005
  4. ncbi Avoidance of neuromuscular blocking agents may increase the risk of difficult tracheal intubation: a cohort study of 103,812 consecutive adult patients recorded in the Danish Anaesthesia Database
    L H Lundstrøm
    Department of Anaesthesia and Intensive Care, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Br J Anaesth 103:283-90. 2009
  5. ncbi IgE-mediated allergy to pholcodine and cross-reactivity to neuromuscular blocking agents: Lessons from flow cytometry
    J Leysen
    Department of Immunology, Allergology and Rheumatology, University Antwerp and Antwerp University Hospital, Antwerpen, Belgium
    Cytometry B Clin Cytom 84:65-70. 2013
  6. pmc Neuromuscular block
    W C Bowman
    Department of Physiology and Pharmacology, University of Strathclyde, Glasgow G4 0NR
    Br J Pharmacol 147:S277-86. 2006
  7. ncbi National survey of the use of sedating drugs, neuromuscular blocking agents, and reversal agents in the intensive care unit
    Denise H Rhoney
    Wayne State University College of Pharmacy and Allied Health Professions Department of Pharmacy Practice, USA
    J Intensive Care Med 18:139-45. 2003
  8. ncbi Postoperative residual curarization from intermediate-acting neuromuscular blocking agents delays recovery room discharge
    A Butterly
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Br J Anaesth 105:304-9. 2010
  9. ncbi Neuromuscular blocking agents decrease inflammatory response in patients presenting with acute respiratory distress syndrome
    Jean Marie Forel
    Réanimation Médicale, Assistance Publique Hopitaux de Marseille, Hopital Sainte Marguerite, Marseille, France
    Crit Care Med 34:2749-57. 2006
  10. ncbi Postoperative residual paralysis in outpatients versus inpatients
    Guy Cammu
    Department of Anesthesiology and Critical Care Medicine, OLV Clinic, Aalst, Belgium
    Anesth Analg 102:426-9. 2006

Research Grants

  1. Implementing Safe Practices for Prevention of Perioperative Hypothermia
    VICTORIA J M STEELMAN; Fiscal Year: 2013
  2. MOLECULAR & ENVIRONMENTAL FACTORS INFLUENCING MH
    Paul Allen; Fiscal Year: 2003
  3. Simulation-Based Treatment Planning for Gait Disorders
    Scott Delp; Fiscal Year: 2007
  4. Ventilator-induced diaphragm dysfunction
    SANFORD NO MIDDLE NAME LEVINE; Fiscal Year: 2010
  5. NEUROTRANSMITTER RECEPTOR DYNAMICS IN VIVO
    Mohammed Akaaboune; Fiscal Year: 2002
  6. Genetic Profiles for Perioperative Applications
    ROBERT KWIATKOWSKI; Fiscal Year: 2001
  7. Effect of Out-of-Hospital Endotracheal Intubation Errors
    Henry Wang; Fiscal Year: 2008
  8. The Effect of Hypertonic Resuscitation for Blunt Trauma
    Eileen Bulger; Fiscal Year: 2005
  9. Hypertonic Modulation of Inflammation following Injury
    Eileen M Bulger; Fiscal Year: 2010
  10. DEVELOPMENT OF AN ORAL CARRIER
    Lance L Simpson; Fiscal Year: 2010

Detail Information

Publications230 found, 100 shown here

  1. ncbi [Monitoring of consciousness with BIS during induction of anesthesia. Which muscle relaxant?]
    S Gazzanelli
    Dipartimento di Scienze Anestesiologiche, Medicina Critica e Terapia del Dolore, Universita degli Studi La Sapienza, Roma
    G Chir 26:163-9. 2005
    ..The BIS-index data show that an opiate as Fentanyl is advisable with associations Cisatracurium/Propofol or Vecuronium/Propofol. It is possible to use in these cases a drip infusion to avoid the risk of awareness during intubation...
  2. ncbi Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision
    T Fuchs-Buder
    Department of Anaesthesiology and Intensive Care Medicine, University of Nancy, France
    Acta Anaesthesiol Scand 51:789-808. 2007
    The set of guidelines for good clinical research practice (GCRP) in pharmacodynamic studies of neuromuscular blocking agents, which was developed following an international consensus conference in Copenhagen, has been revised and updated ..
  3. ncbi Tracheal intubation without the use of neuromuscular blocking agents
    A W Woods
    Stirling Royal Infirmary, Stirling and Anaesthetic Department, Western Infirmary and Gartnavel General Hospital, Glasgow, UK
    Br J Anaesth 94:150-8. 2005
  4. ncbi Avoidance of neuromuscular blocking agents may increase the risk of difficult tracheal intubation: a cohort study of 103,812 consecutive adult patients recorded in the Danish Anaesthesia Database
    L H Lundstrøm
    Department of Anaesthesia and Intensive Care, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Br J Anaesth 103:283-90. 2009
    Previous studies indicate that avoiding neuromuscular blocking agents (NMBAs) may be a risk factor for difficult tracheal intubation (DTI). We investigated whether avoiding NMBA was associated with DTI.
  5. ncbi IgE-mediated allergy to pholcodine and cross-reactivity to neuromuscular blocking agents: Lessons from flow cytometry
    J Leysen
    Department of Immunology, Allergology and Rheumatology, University Antwerp and Antwerp University Hospital, Antwerpen, Belgium
    Cytometry B Clin Cytom 84:65-70. 2013
    ..Immunoglubulin E antibody-mediated allergic reactions to opioids are rare and difficult to document correctly...
  6. pmc Neuromuscular block
    W C Bowman
    Department of Physiology and Pharmacology, University of Strathclyde, Glasgow G4 0NR
    Br J Pharmacol 147:S277-86. 2006
    ....
  7. ncbi National survey of the use of sedating drugs, neuromuscular blocking agents, and reversal agents in the intensive care unit
    Denise H Rhoney
    Wayne State University College of Pharmacy and Allied Health Professions Department of Pharmacy Practice, USA
    J Intensive Care Med 18:139-45. 2003
    The objectives of this study were to describe the sedative, neuromuscular blocking agents (NMBA) and reversal agents utilized in adult intensive care units across the United States and determine the adherence to American College of ..
  8. ncbi Postoperative residual curarization from intermediate-acting neuromuscular blocking agents delays recovery room discharge
    A Butterly
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Br J Anaesth 105:304-9. 2010
    ..9] is associated with increased morbidity and may delay postoperative recovery room (PACU) discharge. We tested the hypothesis that postoperative T4/T1 <0.9 increases PACU length of stay...
  9. ncbi Neuromuscular blocking agents decrease inflammatory response in patients presenting with acute respiratory distress syndrome
    Jean Marie Forel
    Réanimation Médicale, Assistance Publique Hopitaux de Marseille, Hopital Sainte Marguerite, Marseille, France
    Crit Care Med 34:2749-57. 2006
    To evaluate the effects of neuromuscular blocking agents (NMBAs) on pulmonary and systemic inflammation in patients with acute respiratory distress syndrome ventilated with a lung-protective strategy.
  10. ncbi Postoperative residual paralysis in outpatients versus inpatients
    Guy Cammu
    Department of Anesthesiology and Critical Care Medicine, OLV Clinic, Aalst, Belgium
    Anesth Analg 102:426-9. 2006
    ..Although the incidence of residual paralysis was less frequent in surgical outpatients, predictive criteria were not evident...
  11. ncbi Neuromuscular blocking agents' differential bronchoconstrictive potential in Guinea pig airways
    Edmund Jooste
    Department of Anesthesiology, Columbia University, New York, New York 10032, USA
    Anesthesiology 106:763-72. 2007
    b>Neuromuscular blocking agents are designed to antagonize nicotinic cholinergic receptors on skeletal muscle but also antagonize muscarinic receptors...
  12. ncbi Variability of duration of action of neuromuscular-blocking drugs in elderly patients
    S R Arain
    Department of Anaesthesiology, Medical College of Wisconsin, Zablocki VA Medical Center, Milwaukee, WI, USA
    Acta Anaesthesiol Scand 49:312-5. 2005
    ..The objective of the study was to determine if elderly patients had less variability in duration of action with 2 x ED95 of cisatracurium compared to equipotent doses of rocuronium or vecuronium...
  13. ncbi Evaluation of a new routine diagnostic test for immunoglobulin E sensitization to neuromuscular blocking agents
    Dominique Laroche
    Service de Biophysique, Centre Hospitalier Universitaire, Caen, France
    Anesthesiology 114:91-7. 2011
    b>Neuromuscular blocking agents (NMBA) are responsible for most immediate hypersensitivity reactions during anesthesia, as a result of the presence of a quaternary ammonium ion...
  14. ncbi Neuromuscular blockers in early acute respiratory distress syndrome
    Laurent Papazian
    Assistance Publique Hôpitaux de Marseille Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6236, Universite de la Mediterranee Aix Marseille II, Marseille, France
    N Engl J Med 363:1107-16. 2010
    In patients undergoing mechanical ventilation for the acute respiratory distress syndrome (ARDS), neuromuscular blocking agents may improve oxygenation and decrease ventilator-induced lung injury but may also cause muscle weakness...
  15. ncbi Synthesis and structure-activity relationships of neuromuscular blocking agents
    Zoltan Tuba
    Steroid Research Section, Chemical Works of Gedeon Richter Ltd, 10, POB 27, Budapest, H 1475, Hungary
    Curr Med Chem 9:1507-36. 2002
    The first use of neuromuscular blocking agents (muscle relaxants) in clinical practice (1942) revolutionised the practice of anaesthesia and started the modern era of surgery...
  16. ncbi Clinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patient
    Michael J Murray
    Crit Care Med 30:142-56. 2002
  17. ncbi The use of neuromuscular blocking agents to facilitate prehospital intubation does not impair outcome after traumatic brain injury
    Eileen M Bulger
    Departments of Surgery, University of Washington, Harborview Medical Center, Seattle, Washington, USA
    J Trauma 58:718-23; discussion 723-4. 2005
    ..studies have demonstrated that the success rate of prehospital intubation is improved by the use of neuromuscular blocking agents (NMBAs)...
  18. ncbi Incidence and duration of residual paralysis at the end of surgery after multiple administrations of cisatracurium and rocuronium
    D M Maybauer
    Klinik für Anästhesiologie und Intensivmedizin, Philipps Universitat Marburg, Germany
    Anaesthesia 62:12-7. 2007
    ....
  19. ncbi Neuromuscular blocking agents
    Elizabeth A Martinez
    Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A and M University, 4474 TAMU, College Station, TX 77843 4474, USA
    Vet Clin North Am Equine Pract 18:181-8. 2002
    In summary, with proper vigilance, neuromuscular blocking agents can be used safely in anesthetized equine patients to optimize conditions for certain surgical procedures...
  20. ncbi Adverse responses: sedation, analgesia and neuromuscular blocking agents in critically ill children
    Lauren R Sorce
    Pediatric Critical Care, Children s Memorial Hospital, 2300 Children s Plaza Box 246, Chicago, IL 60614, USA
    Crit Care Nurs Clin North Am 17:441-50, xi-xii. 2005
    Advanced practice nurses (APNs) prescribe sedation, analgesia, and neuromuscular blocking agents in the management of critically ill children...
  21. ncbi Canadian survey of the use of sedatives, analgesics, and neuromuscular blocking agents in critically ill patients
    Sangeeta Mehta
    Interdepartmental Division of Critical Care Medicine, Mount Sinai Hospital
    Crit Care Med 34:374-80. 2006
    To characterize the perceived utilization of sedative, analgesic, and neuromuscular blocking agents, the use of sedation scales, algorithms, and daily sedative interruption in mechanically ventilated adults, and to define clinical ..
  22. ncbi The new neuromuscular blocking agents: do they offer any advantages?
    E W Moore
    University Department of Anaesthesia, Liverpool, UK
    Br J Anaesth 87:912-25. 2001
    ..Ninety per cent recovery of the first twitch of the train-of-four occurs after 5-7 min using one ED80. A recovery index of less than 2 min has been reported in rats. All the tropinyl diesters appear to produce vagal block...
  23. ncbi Sevoflurane with remifentanil allows rapid tracheal intubation without neuromuscular blocking agents
    H S Joo
    Department of Anaesthesia and the, Department of Pharmacy St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Can J Anaesth 48:646-50. 2001
    After inhalational induction with sevoflurane, we compared the effects of adding remifentanil 1 microg x kg(-1) or remifentanil 2 microg x kg(-1) on conditions for tracheal intubation without neuromuscular blocking agents.
  24. ncbi [Residual neuromuscular blockades. Clinical consequences, frequency and avoidance strategies]
    T Fuchs-Buder
    Departement d Anesthesie Reanimation, Centre Hospitalier Universitaire de Nancy Brabois
    Anaesthesist 55:7-16. 2006
    ..g. TOF-watch) promises an adequate neuromuscular recovery from the effects of muscle relaxants...
  25. ncbi Use of sedatives, opioids, and neuromuscular blocking agents in patients with acute lung injury and acute respiratory distress syndrome
    Alejandro C Arroliga
    Scott and White, and Texas A and M Health Science Center College of Medicine, Temple, TX, USA
    Crit Care Med 36:1083-8. 2008
    The use of sedatives, opioids, and neuromuscular blocking agents (NMBAs) may delay weaning and prolong intensive care unit length of stay...
  26. ncbi Development and potential clinical impairment of ultra-short-acting neuromuscular blocking agents
    C A Lien
    Department of Anesthesiology, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10021, USA
    Br J Anaesth 107:i60-71. 2011
    ..residual neuromuscular block (NMB) is an increasingly recognized complication of non-depolarizing neuromuscular blocking agents. This occurs because of dosing choices for neuromuscular blocking agents and anticholinesterases as ..
  27. ncbi Pholcodine exposure raises serum IgE in patients with previous anaphylaxis to neuromuscular blocking agents
    T Harboe
    Department of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway
    Allergy 62:1445-50. 2007
    b>Neuromuscular blocking agents (NMBAs) can cause anaphylaxis through immunoglobulin E (IgE) antibodies that bind quaternary ammonium ion epitopes...
  28. ncbi Effect of neuromuscular blocking agents on gas exchange in patients presenting with acute respiratory distress syndrome
    Marc Gainnier
    Service de Reanimation Medicale, hopitaux Sud, Marseille, France
    Crit Care Med 32:113-9. 2004
    To evaluate the effects of a 48-hr neuromuscular blocking agents (NMBA) infusion on gas exchange over a 120-hr time period in patients with acute respiratory distress syndrome.
  29. ncbi Anesthesia and analgesia protocol during therapeutic hypothermia after cardiac arrest: a systematic review
    Carlos Chamorro
    Intensive Care Unit, Puerta de Hierro Majadahonda University Hospital, Majadahonda, Madrid, Spain
    Anesth Analg 110:1328-35. 2010
    ..However, none suggests the best administration protocol. In this study, we evaluated intensivists' preferences regarding administration...
  30. ncbi Adverse reactions to neuromuscular blocking agents
    Paul Michel Mertes
    Departement d Anesthesie Reanimation, CHU de Nancy, Hopital Central, 29 Avenue de Lattre de Tassigny, 54035 Nancy Cedex, France
    Curr Allergy Asthma Rep 4:7-16. 2004
    b>Neuromuscular blocking agents (NMBAs) play a predominant role in the incidence of severe adverse reactions occurring during anesthesia...
  31. ncbi A comparison of two depths of prolonged neuromuscular blockade induced by cisatracurium in mechanically ventilated critically ill patients
    Franck Lagneau
    Department of Anesthesia and Intensive Care Unit, Beaujon Hospital, Universite Paris VII, 100 Boulevard du General Leclerc, 92 118 Clichy Cedex, France
    Intensive Care Med 28:1735-41. 2002
    ..To compare two levels of continuous cisatracurium-induced curarization in hypoxemic, ventilated patients...
  32. ncbi Hypersensitivity reactions to neuromuscular blocking agents
    P M Mertes
    Departement d Anesthesie Reanimation, CHU de Nancy, Hopital Central, 29 Avenue de Lattre de Tassigny, 54035 Nancy Cedex, France
    Curr Pharm Des 14:2809-25. 2008
    b>Neuromuscular blocking agents are the leading drugs responsible for immediate hypersensitivity reactions during anaesthesia. Most hypersensitivity reactions represent IgE-mediated allergic reactions...
  33. ncbi Desflurane and remifentanil use during resection of a cardiac pheochromocytoma
    Ju Mei Ng
    Department of Anaesthesia and Surgical Intensive Care, Singapore General Hospital, Singapore, Singapore
    J Cardiothorac Vasc Anesth 18:630-1. 2004
  34. ncbi Transient cross-resistance to neuromuscular blocking agents in a patient with tetanus
    Jan Wei Chiu
    Department of Rehabilitation, Taipei Veterans General Hospital, and National Yang Ming University, Japan
    Anesthesiology 98:579-81. 2003
  35. ncbi A comparison of the efficacy of cisatracurium and atracurium in kidney transplantation operation
    Siriwan Jirasiritham
    Department of Anesthesiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
    J Med Assoc Thai 87:73-9. 2004
    ....
  36. ncbi Intraoperative jet ventilation during aortic coarctation repair in an infant
    Thomas Cotter
    Department of Anesthesiology, University of Missouri, Columbia, MO 65212, USA
    J Cardiothorac Vasc Anesth 18:207-9. 2004
  37. ncbi The contributions of A. W. Hofmann
    Theodore A Alston
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Anesth Analg 96:622-5, table of contents. 2003
  38. ncbi Rapid sequence intubation for pediatric emergency airway management
    Mark J Sagarin
    Mount Auburn Hospital, Department of Emergency, Cambridge, MA 02138, USA
    Pediatr Emerg Care 18:417-23. 2002
    ..To characterize current practice with respect to pediatric emergency airway management using a multicenter data set...
  39. ncbi Narcolepsy and cardiac surgery: can anesthesia with propofol and remifentanil be safe?
    Raquel Peláez
    Gregorioi Marañón Hospital, Madrid, Spain
    J Cardiothorac Vasc Anesth 18:201-3. 2004
  40. ncbi Assessment of neuromuscular and haemodynamic effects of cisatracurium and vecuronium under sevoflurane-remifentanil anaesthesia in elderly patients
    G T Keles
    Department of Anaesthesiology and Reanimation, Faculty of Medicine, University of Celal Bayar, Manisa, Turkey
    Eur J Anaesthesiol 21:877-81. 2004
    ..Neuromuscular block times, quality of muscle relaxation for tracheal tube insertion, and the haemodynamic effects after cisatracurium and vecuronium under sevoflurane-remifentanil anaesthesia were compared in elderly patients...
  41. ncbi Recovery from neuromuscular block following infusion of cisatracurium using either sevoflurane or propofol for anaesthesia
    G Turan
    Eur J Anaesthesiol 21:751-3. 2004
  42. ncbi Comparison of the neuromuscular blocking effect of cisatracurium and atracurium on the larynx and the adductor pollicis
    K Kirov
    Department of Anesthesia, Hopital Henri Mondor, AP HP, University of Paris XII, Paris, France
    Acta Anaesthesiol Scand 48:577-81. 2004
    ..To understand this discrepancy better, we evaluated the potency and onset of atracurium and cisatracurium directly at the larynx adductors in humans...
  43. ncbi A prospective randomized comparison of train-of-four monitoring and clinical assessment during continuous ICU cisatracurium paralysis
    Michael H Baumann
    Division of Pulmonary and Critical Care Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Chest 126:1267-73. 2004
    ..Train-of-four (TOF) monitoring is often recommended during the continuous use of neuromuscular blockade (NMB) [paralysis] in the ICU. Prior study results are conflicting regarding the benefits of TOF monitoring...
  44. ncbi Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium
    Takahiro Suzuki
    Department of Anesthesiology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York, USA
    Can J Anaesth 50:879-85. 2003
    ..To examine the efficacy of antagonism of rapacuronium-, mivacurium-, rocuronium- and cisatracurium-induced neuromuscular block at the laryngeal adductors (LA)...
  45. ncbi Potential neuroprotective properties of atracurium and cisatracurium in neurosurgical anaesthesia
    V Fodale
    Eur J Anaesthesiol 21:333-4; author reply 334-5. 2004
  46. ncbi The effect of cisatracurium and rocuronium on cisatracurium precurarization and the priming principle
    Peter H K Mak
    Department of Anaesthesiology, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong, Taiwan ROC
    J Clin Anesth 16:83-7. 2004
    ..To demonstrate the effect of administering a precurarizing dose of cisatracurium or rocuronium on the speed of onset of cisatracurium, and to review the possible mechanisms and value of the priming principle...
  47. ncbi Neuromuscular blocking agents and carotid body oxygen sensing
    Malin Jonsson
    Department of Anesthesiology and Intensive Care Medicine, Karolinska Hospital and Institute, Stockholm, Sweden
    Adv Exp Med Biol 536:135-40. 2003
  48. ncbi Possible underestimation of the relative incidence of anaphylactic reactions to benzylisoquinoline neuromuscular blocking agents
    F Lagneau
    Eur J Anaesthesiol 20:577-8. 2003
  49. ncbi Update on muscle relaxants
    Olli Meretoja
    Department of Anaesthesiology, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Paediatr Anaesth 14:384-6. 2004
  50. ncbi Pediatric rapid sequence intubation: a review
    Gregory H Bledsoe
    Department of Emergency Medicine, Center for International Emergency, Disaster, and Refugee Studies, Johns Hopkins Medical Institute, Baltimore, MD, USA
    Pediatr Emerg Care 20:339-44. 2004
    ..This paper is a review of the current recommendations for pediatric rapid sequence intubation including current medications and surgical rescue techniques...
  51. ncbi Neuromuscular blockade does not change the incidence or severity of pharyngolaryngeal discomfort after LMA anesthesia
    Thomas M Hemmerling
    Department of Anesthesiology, Universite de Montreal, Hotel Dieu, 3840 St Urbain, Montreal, Quebec H2W 1T8, Canada
    Can J Anaesth 51:728-32. 2004
    ..This study examined the influence of neuromuscular blockade on the incidence and severity of pharyngolaryngeal discomfort after positive pressure ventilation using a LMA...
  52. ncbi Combined general and epidural anesthesia for a child with alagille syndrome: a case report
    Kathirvel Subramaniam
    Department of Anesthesiology and Critical Care Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Paediatr Anaesth 14:787-91. 2004
    ..We describe the perioperative management of a pediatric patient with Alagille syndrome undergoing ileal exclusion and the specific issues associated with epidural anesthesia with this syndrome...
  53. ncbi Comparative fading responses induced by mivacurium, cisatracurium, and d-tubocurarine in the evoked muscular compound action potentials of the cat
    Takahiro Suzuki
    Department of Anesthesiology, Surugadai Nihon University Hospital, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo 101 8309, Japan
    J Anesth 17:98-103. 2003
    It has been suggested that the different degrees of fade induced by nondepolarizing neuromuscular blocking agents in repetitive muscular contractions may be due to the varying affinities or binding kinetics of presynaptic nicotinic ..
  54. ncbi Train-of-four to monitor neuromuscular blockade?
    Curtis N Sessler
    Chest 126:1018-22. 2004
  55. ncbi Anaesthetic implications of LEOPARD syndrome
    Javier Torres
    The Department of Child Health, The Division of Pediatric Critical Care Pediatric Anesthesiology, The University of Missouri, Columbia, MO 65212, USA
    Paediatr Anaesth 14:352-6. 2004
    ..The potential perioperative implications of LEOPARD syndrome are discussed...
  56. ncbi Anesthetic management of a patient having a carcinoid syndrome
    Samar Jabbour-Khoury
    Department of Anesthesiology, Department of Surgery, American University of Beirut Medical Center, Beirut Libanon
    Middle East J Anesthesiol 17:435-47. 2003
  57. ncbi Cortical activity assessed by Narcotrend in relation to haemodynamic responses to tracheal intubation at different stages of cortical suppression and reflex control
    K Raymondos
    Medical School of Hannover, Department of Anaesthesiology, Hannover, Germany
    Eur J Anaesthesiol 20:44-51. 2003
    ..The aim was to illustrate how haemodynamics may only poorly reflect the level of cortical suppression and that electroencephalographic monitoring could indicate different relationships between cortical effects and haemodynamics...
  58. ncbi Effects of isoflurane on the actions of neuromuscular blockers on the muscle nicotine acetylcholine receptors
    Chuanxiang Li
    Department of Anesthesiology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan 430022, China
    J Huazhong Univ Sci Technolog Med Sci 24:605-6, 614. 2004
    ..Isoflurane increases the potency of NDMRs, possibly by enhancing antagonist affinity at the receptor site...
  59. ncbi Postoperative residual curarization with cisatracurium and rocuronium infusions
    G Cammu
    Ghent University Hospital, Department of Anaesthesia, Belgium
    Eur J Anaesthesiol 19:129-34. 2002
    ..We investigated the recovery characteristics and incidence of postoperative residual curarization after cisatracurium and rocuronium infusions for long duration interventions without systematic antagonism...
  60. ncbi [Comments on the article "Emergency tracheostomy to resolve an unforeseen difficult airway]
    C Añez Simón
    Rev Esp Anestesiol Reanim 53:393-4; author reply 394. 2006
  61. ncbi Cisatracurium or rocuronium versus rocuronium-cisatracurium combination
    Ahed Zeidan
    Department of Anaesthesiology, Sahel General Hospital, Beirut, Lebanon
    Middle East J Anaesthesiol 18:879-86. 2006
    ..However, the combination of 1ED95 cisatracurium with 1ED95 rocuronium provided similar intubating conditions to the 2ED95 rocuronium alone, associated with a significantly less pain on injection...
  62. ncbi General anaesthesia in a patient with motor neuron disease
    B Moser
    Eur J Anaesthesiol 21:921-3. 2004
  63. ncbi Effects of prone position on alveolar dead space and gas exchange during general anaesthesia in surgery of long duration
    M Soro
    Hospital Clinico Universitario, Department of Anaesthesia and Critical Care, Valencia, Spain
    Eur J Anaesthesiol 24:431-7. 2007
    ..We investigated the effects of prone position on respiratory dead space and gas exchange in 14 anaesthetized healthy patients undergoing elective posterior spinal surgery of more than 3 h of duration...
  64. ncbi Tracheal intubating conditions and pharmacodynamics following cisatracurium in infants and children undergoing halothane and thiopental-fentanyl anesthesia
    George H Meakin
    Department of Anaesthesia, Royal Manchester Children s Hospital, Pendlebury, Manchester, UK
    Paediatr Anaesth 17:113-20. 2007
    ..The aims of the present study were to determine the tracheal intubating conditions, onset time, duration of action, and hemodynamic responses following the administration of cisatracurium 0.15 mg x kg(-1) to infants and children...
  65. ncbi Cisatracurium vs. Rocuronium: A prospective, comparative, randomized study in adult patients under total intravenous anaesthesia
    Milan Adamus
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital and Faculty of Medicine, Palacky University, Olomouc, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 150:333-8. 2006
    ..To compare the pharmacodynamics of cisatracurium and rocuronium-induced neuromuscular block following single dose, allowing either spontaneous or neostigmine-accelerated complete recovery...
  66. ncbi [Bispectral index monitoring during intrahospital transport]
    C Hernández-Gancedo
    Servicio de Anestesiologia, Reanimación y Unidad del Dolor, Hospital General Universitario La Paz, Madrid
    Rev Esp Anestesiol Reanim 54:169-72. 2007
    ..The aim of this study was to assess level of sedation as indicated by monitoring of the bispectral (BIS) index during intrahospital transport of critical patients...
  67. ncbi [Effect of propofol in combination with ephedrine upon the onset time of cisatracurium]
    Eduardo Toshiyuki Moro
    Hospital das Clínicas da Faculdade de Medicina da UNESP, CEP 18618 970 Botucatu, Sao Paulo, Brazil
    Rev Assoc Med Bras 53:272-5. 2007
    ..The aim of the present paper was to: 1) compare the haemodynamic effects of adding different doses of ephedrine to an induction dose of propofol and remifentanil. 2) onset time of cisatracurium...
  68. ncbi Skin reactions to intradermal neuromuscular blocking agent injections: a randomized multicenter trial in healthy volunteers
    Paul Michel Mertes
    Department of Anesthesiology, Service d Anesthesie Reanimation, Hopital Central, Centre Hospitalier Universitaire de Nancy, Unité Inserm 684, Faculte de Medecine de Nancy, France
    Anesthesiology 107:245-52. 2007
    Numerous reports confirm the performance of intradermal tests for the diagnosis of anaphylaxis during anesthesia; however, there is controversy over their diagnostic value regarding the newer neuromuscular blocking agents (NMBAs).
  69. ncbi Comparison of cardiac output measurements between NICO and the pulmonary artery catheter during repeat surgery for total hip replacement
    G Gueret
    University Hospital, Anesthesiology and Critical Care Department, La Cavale Blanche, Brest, France
    Eur J Anaesthesiol 24:1028-33. 2007
    ..The aim of this study was to compare cardiac output measurements of the non-invasive cardiac output and the pulmonary artery catheter during repeat surgery for hip replacement...
  70. ncbi Cardiovascular and autonomic nervous effects of edrophonium and atropine combinations during neuromuscular blockade antagonism in sheep
    R Eddie Clutton
    Department of Veterinary Clinical Sciences, Royal Dick School of Veterinary Studies, Easter Bush, Roslin, Midlothian, UK
    Vet Anaesth Analg 35:191-200. 2008
    ..To study heart rate (HR), arterial blood pressure (BP) and autonomic nervous (AN) effects of edrophonium-atropine combinations during neuromuscular blockade (NMB) antagonism in sheep...
  71. ncbi Improved neuromuscular blockade using a novel neuromuscular blockade advisory system: a randomized, controlled, clinical trial
    Terence J Gilhuly
    Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC V6T1Z3, Canada
    Anesth Analg 107:1609-17. 2008
    ..Here, we tested the hypothesis that the use of the NMBAS improves NMB compared to standard care...
  72. ncbi Muscle relaxants--atracurium and other recent developments
    C Ball
    Geoffrey Kaye Museum of Anaesthetic History
    Anaesth Intensive Care 34:295. 2006
  73. ncbi Choice of the hypnotic and the opioid for rapid-sequence induction
    S Lavazais
    , CHU de Poitiers, 350 Avenue Jacques Coeur, 86021, Poitiers, France
    Eur J Anaesthesiol Suppl 23:66-70. 2001
    ....
  74. ncbi Dose requirements and recovery profile of an infusion of cisatracurium during liver transplantation
    Guy Cammu
    Department of Anesthesia, Ghent University Hospital, Belgium
    J Clin Anesth 14:135-9. 2002
    ..To examine the dose requirements and recovery profile of an infusion of cisatracurium during liver transplantation...
  75. ncbi The importance of myorelaxants in anesthesia
    Pamela Flood
    Department of Anesthesiology, Columbia University, 630 West 169th St, New York, NY 10032, USA
    Curr Opin Pharmacol 5:322-7. 2005
    ..These novel approaches to pharmaceuticals, along with improved understanding of the physiology of the neuromuscular junction in health and disease, have made surgical treatment possible in a wide breadth of clinical situations...
  76. ncbi Changes in bispectral index values during lumbar arthrodesis
    E Barrera
    Eur J Anaesthesiol 22:392-3. 2005
  77. ncbi Efficacy of tactile-guided reversal from cisatracurium-induced neuromuscular block
    Hans Kirkegaard
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, USA
    Anesthesiology 96:45-50. 2002
    ..Because tactile evaluation is the most common form of clinical neuromuscular monitoring, this study examines the relative efficacy of antagonizing residual block at different levels of recovery of the tactile train-of-four (TOF) response...
  78. ncbi Cisatracurium versus vecuronium: a comparative, double blind, randomized, multicenter study in adult patients under propofol/fentanyl/N2O anesthesia
    C Melloni
    Anestesia and Resuscitation Unit, City Hospital, Faenza RA, Italy
    Minerva Anestesiol 72:299-308. 2006
    ....
  79. ncbi Use of cisatracurium during fast-track cardiac surgery
    A Ouattara
    , , Poitiers, France
    Br J Anaesth 86:130-2. 2001
    ..Only one patient showed residual paralysis when sedation was discontinued. These results support the use of cisatracurium as a suitable neuromuscular blocking agent for fast-track cardiac surgery...
  80. ncbi Edrophonium antagonism of cisatracurium-induced neuromuscular block: dose requirements in children and adults
    M Abdulatif
    Anaesthesiology Department, Faculty of Medicine, Cairo University, Egypt
    Anaesth Intensive Care 29:364-70. 2001
    ..85 (0.38) and 0.38 (0.19) mg x kg(-1). The equivalent ED(TOF-80) in adults was outside the edrophonium dose range studied...
  81. ncbi Does pancuronium or cisatracurium delay the rate of arousal following remifentanil-based anesthesia?
    Anis S Baraka
    Department of Anesthesiology, American University of Beirut Medical Center, Beirut Lebanon
    Middle East J Anaesthesiol 18:477-84. 2005
    ....
  82. ncbi Anaphylaxis to cisatracurium following negative skin testing
    B A Fraser
    Department of Anaesthesia and Pain Management, Alfred Hospital, Melbourne, Victoria
    Anaesth Intensive Care 33:816-9. 2005
    ..However, the absence of a clearly identified triggering agent increases the difficulties facing the anaesthetist. We present a case of anaphylaxis to cisatracurium following a negative skin test...
  83. ncbi Anesthesia for an adult with mucopolysaccharidosis I
    John L Ard
    Department of Anesthesiology, New York University Medical Center, New York, NY 10016, USA
    J Clin Anesth 17:624-6. 2005
    ..We describe the anesthetic management difficulties of a man with mucopolysaccharidosis I. We also briefly review the anesthesia literature related to this disease...
  84. ncbi The Thai Anesthesia Incidents Study (THAI study) of ambulatory anesthesia: II. Anesthetic profiles and adverse events
    Yodying Punjasawadwong
    Department of Anesthesiology, Chiang Mai University, Chiang Mai 50200, Thailand
    J Med Assoc Thai 91:188-95. 2008
    ..There is a continuing trend to have more elective surgery performed on an outpatient basis...
  85. ncbi Assessment of the potential for displacement interactions with sugammadex: a pharmacokinetic-pharmacodynamic modelling approach
    Alex Zwiers
    Schering Plough Research Institute, a Division of MSD, Newhouse, Scotland, UK
    Clin Drug Investig 31:101-11. 2011
    Sugammadex is a γ-cyclodextrin that binds with high affinity to the neuromuscular blocking agents (NMBAs) rocuronium (bromide) and vecuronium (bromide) by encapsulation...
  86. ncbi Residual postoperative paralysis. Pancuronium versus mivacurium, does it matter?
    A F Kopman
    New York Medical College, Valhalla, USA
    Anesthesiology 85:1253-9. 1996
    ..The authors reexamined the incidence of postoperative weakness after the administration of long- and short-acting neuromuscular blockers because few, if any, such comparative studies are available...
  87. ncbi [Clinical consequences of neuromuscular impairments in critically ill patients]
    A Mesejo
    Servicio de Medicina Intensiva, Hospital Clinico Universitario de Valencia
    Nutr Hosp 21:104-13. 2006
    ....
  88. ncbi Electromyographic study of differential sensitivity to succinylcholine of the diaphragm, laryngeal and somatic muscles: a swine model
    I Cheng Lu
    Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 26:640-6. 2010
    b>Neuromuscular blocking agents (NMBAs) might diminish the electromyography signal of the vocalis muscles during intraoperative neuromonitoring of the recurrent laryngeal nerve...
  89. ncbi Interaction between nondepolarizing neuromuscular blocking agents and inhalational anesthetics
    J Swen
    Department of Anesthesiology, University Hospital Leiden, The Netherlands
    Anesth Analg 69:752-5. 1989
    Although many studies have presented data based on administration of nondepolarizing neuromuscular blocking agents to patients given inhalation anesthesia for 30-45 min, no data exist on the interaction in a clinical situation where the ..
  90. ncbi [The use of curare-like agents in resuscitation]
    A Suppini
    Departement d Anesthesie Reanimation, Hopital d Instruction des Armees Sainte Anne, Toulon, France
    Ann Fr Anesth Reanim 18:341-54. 1999
    To analyse current data on use of neuromuscular blocking agents (NBA) in the intensive therapy unit (ITU) patients and to propose practice guidelines.
  91. ncbi Risk factors for sensorineural hearing loss in survivors with severe congenital diaphragmatic hernia
    Kouji Masumoto
    Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka, Japan
    Eur J Pediatr 166:607-12. 2007
    ..SNHL and the remaining 12 patients without SNHL, regarding such factors as the use of ototoxic drugs, neuromuscular blocking agents, high-frequency oscillation (HFO), and inhaled nitric oxide, the duration of hypocapnia, hypoxia, ..
  92. ncbi [Influence of lithium on the neuromuscular blockade produced by atracurium and cisatracurium: study on rat phrenic nerve-diaphragm preparations.]
    Samanta Cristina Antoniassi Fernandes
    Departamento de Farmacologia, FCM, UNICAMP
    Rev Bras Anestesiol 57:289-300. 2007
    ..The objective of this study was to evaluate, on the rat diaphragm, the effects of lithium on the muscular response and indirect stimulation, and the possible interaction with neuromuscular blockers...
  93. ncbi Tetanus: pathophysiology and management
    M E Ernst
    College of Pharmacy, University of Iowa, Iowa City 52242, USA
    Ann Pharmacother 31:1507-13. 1997
    ..To review the epidemiology, pathophysiology, clinical manifestations, diagnosis, and management of tetanus and its complications...
  94. ncbi Increased sensitivity to depolarization and nondepolarizing neuromuscular blocking agents in young rat hemidiaphragms
    L P Fortier
    Département d Anesthésiologie, Universite de Montreal, Quebec, Canada
    Anesthesiology 95:478-84. 2001
    ..The purpose of this study was to determine the relative sensitivity of newborn neuromuscular junctions to succinylcholine and five nondepolarizing agents...
  95. ncbi Influence of gender on the course of neuromuscular block following a single bolus dose of cisatracurium or rocuronium
    M Adamus
    Department of Anaesthesiology and Intensive Care Medicine, Palacky University, University Hospital and Faculty of Medicine, Olomouc, Czech Republic
    Eur J Anaesthesiol 25:589-95. 2008
    ..increasing evidence of gender differences in the pharmacokinetics and pharmacodynamics of aminosteroid neuromuscular blocking agents. Compared to males, females are more susceptible, requiring approximately 30% less rocuronium to ..
  96. ncbi Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor
    Malin Jonsson Fagerlund
    Department of Anesthesiology and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden
    Anesthesiology 110:1244-52. 2009
    Nondepolarizing neuromuscular blocking agents (NMBAs) are classic competitive-inhibitors at the muscle nicotinic acetylcholine receptor (nAChR)...
  97. ncbi Pharmacological evaluation of contractile activity of the dog heartworm Dirofilaria immitis
    J M Bowen
    College of Veterinary Medicine, University of Georgia, Athens, GA 30602 7371, USA
    Vet Res Commun 32:231-41. 2008
    ..Atropine and monensin had inhibitory effects. Neostigmine, the neuromuscular blocking agents decamethonium, succinylcholine, and D-tubocurarine, and the aminergic agents epinephrine, ..
  98. ncbi Reduced-dose rocuronium for day-case tonsillectomy in children where volatile anaesthetics are not used: operating room time saving
    Dubravka Bartolek
    Department of Anaesthesiology and Intensive Care Medicine, University Clinic of Traumatology, Kuhaceva, Zagreb, Croatia
    Paediatr Anaesth 20:47-55. 2010
    Mivacurium, rocuronium, and vecuronium are neuromuscular blocking agents (NMB) commonly used in pediatric day-case anesthesia...
  99. ncbi The effect of non-depolarizing neuromuscular blocking agents on the release of acetylcholine from the right atrium of the guinea pig
    N Manabe
    Department of Anesthesiology and Rescusitology, Okayama University Medical School, Japan
    Acta Med Okayama 51:13-8. 1997
    The effect of various non-depolarizing neuromuscular blocking agents (gallamine, pancuronium, vecuronium, d-tubocurarine, metocurine, atracurium and pipecuronium) on [3H]acetylcholine release in the response to field electrical ..
  100. ncbi Anaphylaxis during surgical and interventional procedures
    Bernard Yu Hor Thong
    Department of Rheumatology, Allergy, and Immunology, Tan Tock Seng Hospital, Singapore
    Ann Allergy Asthma Immunol 92:619-28. 2004
    ..To describe the current evidence-based knowledge of the causes, diagnostic evaluation, and treatment of patients with anaphylaxis associated with surgical and interventional procedures...
  101. ncbi Newer neuromuscular blocking agents
    D R Bevan
    UBC Department of Anaesthesia, Vancouver General Hospital, B C, Canada
    Pharmacol Toxicol 74:3-9. 1994
    ..The indications for succinylcholine will not disappear and the search for a non-polarizing replacement will continue...

Research Grants14

  1. Implementing Safe Practices for Prevention of Perioperative Hypothermia
    VICTORIA J M STEELMAN; Fiscal Year: 2013
    ..Perioperative hypothermia increases the duration of action of anesthesia and neuromuscular blocking agents and extends postanesthesia recovery by an average of 90 minutes...
  2. MOLECULAR & ENVIRONMENTAL FACTORS INFLUENCING MH
    Paul Allen; Fiscal Year: 2003
    ....
  3. Simulation-Based Treatment Planning for Gait Disorders
    Scott Delp; Fiscal Year: 2007
    ..likely to benefit more from other treatments, such as bracing, strengthening exercises, injections of neuromuscular blocking agents, or other surgeries...
  4. Ventilator-induced diaphragm dysfunction
    SANFORD NO MIDDLE NAME LEVINE; Fiscal Year: 2010
    ..pulmonary nodule (SPN) that is (a) the same age [unreadable]5 years;(b) same gender;(c) receives neuromuscular blocking agents <3 hours before intra- operative diaphragm biopsy;(d) pathology on SPN shows benign disease;and (e) ..
  5. NEUROTRANSMITTER RECEPTOR DYNAMICS IN VIVO
    Mohammed Akaaboune; Fiscal Year: 2002
    ..This question is clinically important because patients who have been treated with neuromuscular blocking agents for several days occasionally remain paralyzed for weeks after removing the blocking agents...
  6. Genetic Profiles for Perioperative Applications
    ROBERT KWIATKOWSKI; Fiscal Year: 2001
    ..of established clinical validity and utility at 12 loci predicting differences in patient responses to neuromuscular blocking agents (BChE, RYR1, CACNA1S), opioids and antiarrythmics (CYP2D6), nitrous oxide (MTHFR, MTR, MTRR, CBS), ..
  7. Effect of Out-of-Hospital Endotracheal Intubation Errors
    Henry Wang; Fiscal Year: 2008
    ..These analyses are innovative in the fields of EMS, patient safety and health services research and will help to justify system-wide efforts to reduce errors in this complex procedure. ..
  8. The Effect of Hypertonic Resuscitation for Blunt Trauma
    Eileen Bulger; Fiscal Year: 2005
    ..abstract_text> ..
  9. Hypertonic Modulation of Inflammation following Injury
    Eileen M Bulger; Fiscal Year: 2010
    ..The results of these studies will provide valuable information to determine the ultimate therapeutic use of the resuscitation strategy. ..
  10. DEVELOPMENT OF AN ORAL CARRIER
    Lance L Simpson; Fiscal Year: 2010
    ..To demonstrate an absence of toxicity of the modified carrier and the modified carrier~tetanus antigen construct If successful, this work should demonstrate that a mucosal tetanus vaccine is worthy of evaluation as a clinical product. ..
  11. Dissection of Ethanol Actions on Cholinergic Nerve Endings
    TIMOTHY SEARL; Fiscal Year: 2008
    ..Our preliminary data with botulinums toxins demonstrate that the synaptic vesicle protein synaptobrevin is an important target for the effects of ethanol. [unreadable] [unreadable] [unreadable] [unreadable]..
  12. ANESHETIC MODULATION OF NATIVE NICOTINIC RECEPTORS
    Pamela Flood; Fiscal Year: 2003
    ..The resulting information will provide understanding of the molecular mechanism underlying one of the anesthetic effects that limit anesthetic safety. ..
  13. Kinetics of Ligand Binding to Synaptic Ion Channels
    JAMES DILGER; Fiscal Year: 2006
    ..4. Use isothermal titration calorimetry to measure the thermodynamics of ligand binding to acetylcholine binding protein - a water soluble protein whose structure is being used as a template for the acetylcholine receptor. ..
  14. MECHANISM OF BOTULINUM TOXIN ACTION
    LANCE SIMPSON; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..