autonomic agents

Summary

Summary: Agents affecting the function of, or mimicking the actions of, the autonomic nervous system and thereby having an effect on such processes as respiration, circulation, digestion, body temperature regulation, certain endocrine gland secretions, etc.

Top Publications

  1. ncbi Noninvasive evaluation of contractile behavior of cardiomyocyte monolayers based on motion vector analysis
    Tomohiro Hayakawa
    Life Science Laboratory, Advanced Material Laboratories, Sony Corporation, Tokyo, Japan
    Tissue Eng Part C Methods 18:21-32. 2012
  2. ncbi Effects of autonomic agents and chemical mediators on ion transport by canine tracheal epithelium
    K Sugahara
    Department of Anesthesiology, Kumamoto University Medical School, Japan
    Jpn J Physiol 39:421-8. 1989
  3. ncbi Pharmacologic studies of Hirschsprung's disease on a murine model
    J Richardson
    J Pediatr Surg 10:875-84. 1975
  4. ncbi PM-induced cardiac oxidative stress and dysfunction are mediated by autonomic stimulation
    Claudia R Rhoden
    Department of Environmental Health, Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA
    Biochim Biophys Acta 1725:305-13. 2005
  5. ncbi The autonomic control of accommodation and implications for human myopia development: a review
    Jennifer C Chen
    Centre for Eye Research, School of Optometry, Queensland University of Technology, Victoria Park Road, Kelvin Grove, Brisbane QLD 4059, Australia
    Ophthalmic Physiol Opt 23:401-22. 2003
  6. ncbi Hypotensive effect of push-pull gravitational stress occurs after autonomic blockade
    Don D Sheriff
    Department of Exercise Science, The University of Iowa, Iowa City, Iowa 52242, USA
    J Appl Physiol (1985) 95:167-71. 2003
  7. ncbi Neuronal locus and cellular signaling for stimulation of ileal giant migrating and phasic contractions
    Sushil K Sarna
    Enteric Neuromusclular Disorders and Visceral Pain Center, Department of Internal Medicine, Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77555 0632, USA
    Am J Physiol Gastrointest Liver Physiol 284:G789-97. 2003
  8. ncbi Medication-induced hyposalivation: etiology, diagnosis, and treatment
    Paul A Moore
    Department of Anesthesiology, School of Dental Medicine, University of Pittsburgh, Pennsylvania, USA
    Compend Contin Educ Dent 29:50-5. 2008
  9. pmc Haemodynamic and abdominal motor reflexes elicited by neurotensin in anaesthetized guinea-pigs
    F Rioux
    Centre de Recherche, Universite Laval, Hotel Dieu de Quebec, Canada
    Br J Pharmacol 106:187-95. 1992
  10. ncbi Computer simulation models are implementable as replacements for animal experiments
    Dinesh K Badyal
    Department of Pharmacology, Christian Medical College, Ludhiana, India
    Altern Lab Anim 37:191-5. 2009

Research Grants

Scientific Experts

Detail Information

Publications118 found, 100 shown here

  1. ncbi Noninvasive evaluation of contractile behavior of cardiomyocyte monolayers based on motion vector analysis
    Tomohiro Hayakawa
    Life Science Laboratory, Advanced Material Laboratories, Sony Corporation, Tokyo, Japan
    Tissue Eng Part C Methods 18:21-32. 2012
    ..Effects of autonomic agents (acetylcholine or epinephrine [EPI]) or EPI and propranolol on cardiomyocytes were clearly detected by the ..
  2. ncbi Effects of autonomic agents and chemical mediators on ion transport by canine tracheal epithelium
    K Sugahara
    Department of Anesthesiology, Kumamoto University Medical School, Japan
    Jpn J Physiol 39:421-8. 1989
    ..Thus, the effects of autonomic agents and chemical mediators on ion transport may explain, in part, the pathogenesis of airway disorders observed ..
  3. ncbi Pharmacologic studies of Hirschsprung's disease on a murine model
    J Richardson
    J Pediatr Surg 10:875-84. 1975
    ..It is proposed that absence of this inhibitory system in the aganglionic portion of the bowel results in the principal pathophysiologic findings in Hirschsprung's disease...
  4. ncbi PM-induced cardiac oxidative stress and dysfunction are mediated by autonomic stimulation
    Claudia R Rhoden
    Department of Environmental Health, Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA
    Biochim Biophys Acta 1725:305-13. 2005
    ..These data indicate that PM exposure increases cardiac oxidants via autonomic signals and the resulting oxidative stress is associated with significant functional alterations in the heart...
  5. ncbi The autonomic control of accommodation and implications for human myopia development: a review
    Jennifer C Chen
    Centre for Eye Research, School of Optometry, Queensland University of Technology, Victoria Park Road, Kelvin Grove, Brisbane QLD 4059, Australia
    Ophthalmic Physiol Opt 23:401-22. 2003
    ..The collective results of this research point to anomalous accommodation responses, possibly as a result of underlying anomalous autonomic input to the ciliary muscle, being involved in myopia development and progression...
  6. ncbi Hypotensive effect of push-pull gravitational stress occurs after autonomic blockade
    Don D Sheriff
    Department of Exercise Science, The University of Iowa, Iowa City, Iowa 52242, USA
    J Appl Physiol (1985) 95:167-71. 2003
    ..05). Cardiac output fell similarly in both conditions. Thus a push-pull effect attributable to a rise in total vascular conductance occurs when autonomic function is inhibited...
  7. ncbi Neuronal locus and cellular signaling for stimulation of ileal giant migrating and phasic contractions
    Sushil K Sarna
    Enteric Neuromusclular Disorders and Visceral Pain Center, Department of Internal Medicine, Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77555 0632, USA
    Am J Physiol Gastrointest Liver Physiol 284:G789-97. 2003
    ..In conclusion, acetylcholine is the common neurotransmitter for the stimulation of both GMCs and RPCs, but the signaling cascades for their stimulation are partially divergent, and they differ also in the normal and inflamed states...
  8. ncbi Medication-induced hyposalivation: etiology, diagnosis, and treatment
    Paul A Moore
    Department of Anesthesiology, School of Dental Medicine, University of Pittsburgh, Pennsylvania, USA
    Compend Contin Educ Dent 29:50-5. 2008
    ..The general approach to patients with hyposalivation and xerostomia is directed at palliative treatment for the relief of symptoms and prevention of oral complications...
  9. pmc Haemodynamic and abdominal motor reflexes elicited by neurotensin in anaesthetized guinea-pigs
    F Rioux
    Centre de Recherche, Universite Laval, Hotel Dieu de Quebec, Canada
    Br J Pharmacol 106:187-95. 1992
    ..The nature and time-response characteristics of the reflexes caused by i.p. NT, raise the possibility that i.p. NT is a noxious stimulus, at least in guinea-pigs...
  10. ncbi Computer simulation models are implementable as replacements for animal experiments
    Dinesh K Badyal
    Department of Pharmacology, Christian Medical College, Ludhiana, India
    Altern Lab Anim 37:191-5. 2009
    ..The CSM programme can be implemented in existing teaching schedules for pharmacology undergraduate teaching with basic infrastructure support, and is readily adaptable for use by other institutes...
  11. ncbi Strain-specific patterns of autonomic nervous system activity and heart failure susceptibility in mice
    Vladimir Shusterman
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Heart Circ Physiol 282:H2076-83. 2002
    ..Mean HR, but not indexes of HR variability, was an excellent predictor of response to autonomic agents. The proportion of surviving animals was higher in TNF-alpha mice on an FVB background than on a mixed FVB/..
  12. ncbi Withdrawal of fall-risk-increasing drugs in older persons: effect on mobility test outcomes
    Nathalie van der Velde
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Drugs Aging 24:691-9. 2007
    ..Improvement of mobility may be an important factor in this finding and we therefore tested whether mobility tests improved after FRID withdrawal...
  13. ncbi Safety of botulinum neurotoxin treatment in patients with chronic anal fissure
    Donatella Brisinda
    Dis Colon Rectum 46:419-20. 2003
  14. ncbi Microdialysis for pharmacokinetic-pharmacodynamic studies
    W Yu
    Department of Pharmaceutics, College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, China
    Pharmazie 62:883-91. 2007
    ....
  15. ncbi Hormone-induced granular convoluted tubule-like cells in mouse parotid gland
    Shingo Kurabuchi
    Department of Histology, The Nippon Dental University School of Life Dentistry, Tokyo, Japan
    J Med Invest 56:290-5. 2009
    ..SD cells, the immunocytochemistry of their secretory products, and their secretory responses to some autonomic agents are reviewed...
  16. ncbi Tachykinin receptors as drug targets for motility disorders
    Willemijntje A Hoogerwerf
    Department of Internal Medicine, Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, The University of Texas Medical Branch, Galveston, TX 77555 1064, USA
    Dig Dis 24:83-90. 2006
    ..This is, in part, due to the complex and multilevel of regulation of gastrointestinal motility function and the challenges faced in targeting the specific type of gut contraction to normalize function in disease state...
  17. ncbi Mixed actions of hemicholinium at autonomic receptor sites of the rat vas deferens
    H F Miranda
    Department of Pharmacology, School of Medicine, Universidad Central del Caribe, Cayey, PR
    Gen Pharmacol 18:643-5. 1987
    1. The effects of hemicholinium (HC-3) on several autonomic agents in the isolated rat vas deferens were investigated. 2. HC-3 reduced slightly the effects of NE and DA. 3...
  18. ncbi Shock-induced ultrasonic vocalization in young adult rats: a model for testing putative anti-anxiety drugs
    J De Vry
    Department of Psychopharmacology, Troponwerke, Cologne, Germany
    Eur J Pharmacol 249:331-9. 1993
    ....
  19. ncbi Clinical disorders of the autonomic nervous system associated with orthostatic intolerance: an overview of classification, clinical evaluation, and management
    B P Grubb
    Division of Cardiology, Medical College of Ohio, Toledo 43614 5809, USA
    Pacing Clin Electrophysiol 22:798-810. 1999
    ..As this consciousness changes, so does the world." On going studies will continue to help better define the broad spectrum of these disorders, and to elaborate better diagnostic and treatment modalities...
  20. ncbi Nitric oxide in the control of submandibular gland function in the anaesthetized ferret
    G Tobin
    Department of Pharmacology, University of Goteborg, Sweden
    Exp Physiol 82:825-36. 1997
    ....
  21. ncbi Function and distribution of autonomic receptors in canine ureteral smooth muscle
    T Morita
    Department of Urology, Tokyo Medical and Dental University School of Medicine, Japan
    Neurourol Urodyn 13:315-21. 1994
    ..It is also suggested that prostaglandins directly affect canine ureteral contraction...
  22. ncbi Calcitonin gene-related peptide (CGRP)-evoked inotropism during hyper- and hypo-sensory-motor innervation in rat atria
    A Rubino
    Department of Anatomy and Developmental Biology, University College London, UK
    J Auton Pharmacol 17:121-7. 1997
    ..Down-regulation of CGRP receptors or altered post-receptor signalling may be involved in the reduced responsiveness to CGRP...
  23. ncbi Stroke
    J Kokkinos
    Department of Neurology, Henry Ford Hospital, Detroit, Michigan
    Neurol Clin 11:577-90. 1993
    ..Oral contraceptives may increase the risk of stroke in female patients over 35 years of age who also have other risk factors...
  24. ncbi Modulation by drugs acting on the autonomic nervous system of platelet-activating factor in the stomach of rats
    J Sugatani
    Department of Medical Chemistry, Kansai Medical University, Osaka, Japan
    Biochem Pharmacol 46:37-45. 1993
    ..Gastric endogenous PAF levels are closely associated with the autonomic nervous system and should be considered further in investigations of gastric function...
  25. ncbi The effect of pharmacological stimulation and blockade of autonomic receptors on the urethral pressure and power generation during coughing and squeezing of the pelvic floor in healthy females
    P Thind
    Department of Urology, Rigshospitalet, University of Copenhagen, Denmark
    Scand J Urol Nephrol 27:519-25. 1993
    ..They furthermore indicate that investigations on the ability to secure continence cannot be based solely on resting pressure profilometry, but should be accomplished by measurements during stress episodes...
  26. ncbi Perspectives in the medical treatment of glaucoma
    W C Stewart
    Pharmaceutical Research Corporation, Charleston, SC 29412 2464, USA
    Curr Opin Ophthalmol 10:99-108. 1999
    ..In the future, newer medical therapies that may protect the health of the optic nerve directly could be developed including blood flow-based, neuroprotective, and genetically based agents...
  27. ncbi Human ejaculatory duct: parameters of smooth muscle motor activity and modulatory role of autonomic drugs
    R Mancinelli
    Department of Applied Science to Biosystems, Section of Human Physiology, University of Cagliari, Via Porcell 4, I 09124 Cagliari, Urologic Clinic, University of Torino, Corso Bramante 8, I 10134 Torino, Italy
    Exp Physiol 85:465-7. 2000
    ....
  28. ncbi Syncope resulting from autonomic insufficiency syndromes associated with orthostatic intolerance
    B P Grubb
    Division of Cardiology, Department of Medicine, Medical College of Ohio, Toledo, Ohio, USA
    Med Clin North Am 85:457-72. 2001
    ..A basic understanding of these disorders is essential to diagnosis and proper treatment. Ongoing studies should help to define better the spectrum of these disorders and to elaborate better diagnostic and treatment modalities...
  29. ncbi Autonomic effects of suggestive placebo interventions to increase or decrease blood pressure: a randomized controlled trial in healthy subjects
    Frank Zimmermann-Viehoff
    Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    J Psychosom Res 75:32-5. 2013
    ..Our randomized-controlled trial aimed to investigate autonomic responses after a suggestive placebo intervention intended to increase or decrease blood pressure (BP)...
  30. ncbi Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex
    Cédric M Hysek
    Division of Clinical Pharmacology and Toxicology, Departments of Biomedicine and Internal Medicine, University Hospital Basel and University of Basel, Hebelstrasse 2, CH 4031 Basel, Switzerland
    Psychopharmacology (Berl) 224:363-76. 2012
    ..Pupillometry can be used to characterize autonomic drug effects...
  31. ncbi Atypical antipsychotics--effects of amisulpride on salivary secretion and on clozapine-induced sialorrhea
    T Godoy
    Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Goteborg, Sweden
    Oral Dis 18:680-91. 2012
    ..However, objective measurements of its effectiveness are lacking and, preclinically, amisulpride has no effect. We currently hypothesise that amisulpride acts by reducing the nervous- rather than the clozapine-driven salivary secretion...
  32. ncbi Exploring the potential effect of polypharmacy on the hematologic profiles of clozapine patients
    Michael D Shuman
    Human, Trigoboff, and DEMLER State University of New York, Buffalo, and New York State Office of Mental Health OPLER Columbia University Medical Center, New York, NY
    J Psychiatr Pract 20:50-8. 2014
    ..Complications of agranulocytosis can be severe and include increased risk of infection and mortality...
  33. pmc Intraoperative floppy iris syndrome: pathophysiology, prevention, and treatment
    Allan J Flach
    Department of Ophthalmology, University of California, San Francisco UCSF Medical Center, USA
    Trans Am Ophthalmol Soc 107:234-9. 2009
    ..To extend upon previous reports, observations, and discussions of intraoperative floppy iris syndrome (IFIS) with the goal of providing new insight into the syndrome's pathophysiology, prevention, and treatment...
  34. ncbi Experimental and clinical basis for the use of statins in patients with ischemic and nonischemic cardiomyopathy
    Kumudha Ramasubbu
    Winters Center for Heart Failure Research, Department of Medicine, Baylor College of Medicine and the Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    J Am Coll Cardiol 51:415-26. 2008
    ..This review will examine the potential benefits of statins in HF patients with ischemic and nonischemic cardiomyopathy as well as potential concerns regarding the use of statins in these patients...
  35. pmc Cardiac regulation in the socially monogamous prairie vole
    Angela J Grippo
    Department of Psychiatry and Brain Body Center, University of Illinois at Chicago, 1601 W Taylor St MC 912, Chicago, IL 60612, United States
    Physiol Behav 90:386-93. 2007
    ..The current results provide a foundation for studying neural and social regulation of cardiac function during different behavioral states in this socially monogamous rodent model...
  36. ncbi Medication effects on metabolic rate: a systematic review (part 1)
    Roland N Dickerson
    University of Tennessee Health Sciences Center, 26 S Dunlap Street, Memphis, TN 38163, USA
    J Am Diet Assoc 105:835-43. 2005
  37. ncbi Autonomic regulation of calcium and potassium channels is oppositely modulated by microtubules in cardiac myocytes
    Ana M Gomez
    Physiopathologie Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale U 637, EA 3759, Centre Hospitalier Universitaire Arnaud de Villeneuve, F 34295 Montpellier, France
    Am J Physiol Heart Circ Physiol 286:H2065-71. 2004
    ..Summarily, colchicine treatment reverses regulation of ventricular excitation-contraction coupling by autonomic agents.
  38. ncbi Autonomic nervous responses according to preference for the odor of jasmine tea
    Naohiko Inoue
    Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake cho, Kyoto 606 8502, USA
    Biosci Biotechnol Biochem 67:1206-14. 2003
    ..These results suggest that the jasmine tea odor activated the parasympathetic nerve, whereas the higher-intensity odor activated the sympathetic nerve in those subjects who disliked the odor...
  39. ncbi Overexpression of eNOS in RVLM improves impaired baroreflex control of heart rate in SHRSP. Rostral ventrolateral medulla. Stroke-prone spontaneously hypertensive rats
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Hypertension 41:255-60. 2003
    ..These results indicate that an increase in NO production in the RVLM improves the impaired baroreflex control of HR in SHRSP and that these effects may have resulted from a cardiac sympathoinhibitory effect of NO in the RVLM of SHRSP...
  40. ncbi [Characterization of histaminergic receptors in the urinary bladder of sheep]
    S Benedito
    Catedra de Fisiologia, Facultad de Veterinaria, Universidad Complutense de Madrid, Espana
    Rev Esp Fisiol 43:323-7. 1987
    ..The histamine had a contractile effect mediated specifically through H1 receptors. It appears that the effect of histamine is not mediated through either a cholinergic or an adrenergic mechanism...
  41. ncbi Cardiac electrophysiologic effects of orally administered DPI 201-106 in conscious canines: effects of pharmacologic autonomic blockade or cardiac transplantation
    M J Walker
    Department of Medicine, University of Minnesota Medical School, Minneapolis
    J Cardiovasc Pharmacol 14:381-8. 1989
    ..Thus, findings in this study indicate that the apparent cardiac electrophysiologic effects of DPI are predominantly of neurally mediated origin in this animal model...
  42. ncbi Degranulation of acinar cells in von Ebner's gland of the rat
    H Ueba
    Department of Physiology, Osaka Dental University
    J Osaka Dent Univ 25:35-49. 1991
    ..We concluded that the activation of the sympathetic alpha 2- and beta 1-receptors, as well as the M2 (M2 beta)-muscarinic and substance P receptors, results in degranulation of acinar cells in von Ebner's gland of the rat...
  43. ncbi Effects of some autonomic drugs and neuropeptides on the mechanical activity of longitudinal and circular muscle strips isolated from the carp intestinal bulb (Cyprinus carpio)
    T Kitazawa
    Department of Veterinary Pharmacology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Aomori, Japan
    Comp Biochem Physiol C 97:13-24. 1990
    ....
  44. ncbi Direct and neurohumoral cardiovascular effects of atrial natriuretic peptide
    R L Woods
    Baker Medical Research Institute, Melbourne, Australia
    J Cardiovasc Pharmacol 13:177-85. 1989
    ..The magnitude of reflex autonomic effects appeared to be less than expected for the observed fall in MAP, suggesting that ANP also inhibited cardiovascular reflexes...
  45. pmc The effect of autonomic blockers on heart rate: a comparison between two ethnic groups
    E C Meyer
    Department of Pharmacology, University of Pretoria, South Africa
    Br J Clin Pharmacol 29:254-6. 1990
    ..However, after prior beta-adrenoceptor blockade, these differences were no longer significant. It is postulated that a varying pharmacogenetic sensitivity to autonomic blockers may result from inequality of vagal or sympathetic tone...
  46. ncbi The role of endothelium in the phenylephrine-induced oscillatory responses of rabbit mesenteric arteries
    M Omote
    Development Laboratories Hirakata Center, Marion Merrell Dow K K, Osaka, Japan
    Jpn J Pharmacol 59:37-41. 1992
    ..These results suggest that phenylephrine-induced oscillation is mediated by an endothelium-derived factor such as EDRF and depends on the influx of extracellular calcium ions...
  47. ncbi A model of cardiovascular activation components for studies using autonomic receptor antagonists
    G Stemmler
    Forschungsgruppe Psychophysiologie, University of Freiburg, Germany
    Psychophysiology 28:367-82. 1991
    ..Lastly, the utility of the Activation Components Model for a componential description of tasks and for componential intertask relationships is illustrated with data from the literature...
  48. ncbi The effects of autonomic drugs on the concentration of kallikrein-like proteases and cysteine-proteinase inhibitor (cystatin) in rat whole saliva
    G S Bedi
    Department of Oral Biology, School of Dental Medicine, State University of New York, Buffalo 14214
    J Dent Res 70:924-30. 1991
    ..The salivary mucin showed an increase in reactivity and increased mobility in saliva from both isoproterenol- and phenylephrine-treated animals.(ABSTRACT TRUNCATED AT 250 WORDS)..
  49. ncbi Clinical implications of autonomic drugs
    D E Becker
    Sinclair Community College, Dayton, OH 45402
    J Oral Maxillofac Surg 50:734-40. 1992
    ..This article summarizes principles of autonomic pharmacology and highlights specific drugs that are useful to the practicing oral and maxillofacial surgeon...
  50. ncbi Lysosomotropic behavior of adrenergic antagonists in interactions with human neutrophils
    B Styrt
    Department of Medicine, Tufts University School of Medicine, Boston, MA
    Biochem Pharmacol 37:435-41. 1988
    ..b>Autonomic agents are also weak bases which might modify cell function by accumulating in the acidic interior of the lysosome, ..
  51. ncbi Effects of culture supernatant from Lactobacillus pentosus strain S-PT84 on autonomic nerve activity in rats
    Yoshinori Beppu
    Frontier Center for Value Creation, Engineering and Process Development Division, Suntory Business Expert Limited, Shimamoto cho, Mishima gun, Osaka, Japan
    In Vivo 26:355-9. 2012
    ....
  52. ncbi Emerging drugs for autonomic dysfunction in Parkinson's disease
    Santiago Perez-Lloret
    University of Toulouse III, University Hospital, Department of Clinical Pharmacology and Neuroscience, Toulouse, France
    Expert Opin Emerg Drugs 18:39-53. 2013
    ..Even though its treatment has been recognized as a major unmet need in PD, there is a paucity of clinical trials to assess their treatment...
  53. ncbi The contractile effect of anandamide in the guinea-pig small intestine is mediated by prostanoids but not TRPV1 receptors or capsaicin-sensitive nerves
    András Dékány
    Department of Pharmacology and Pharmacotherapy, University Medical School of Pecs, Pecs, Hungary
    Basic Clin Pharmacol Toxicol 112:341-5. 2013
    ..It is concluded that the capsaicin-insensitive, neuronal excitatory effect of anandamide in the intestine is most probably mediated by cyclooxygenase products. Such a mechanism may also play a role at other sites in the mammalian body...
  54. ncbi Effect of losartan, an angiotensin II type 1 receptor antagonist on cardiac autonomic functions of rats during acute and chronic inhibition of nitric oxide synthesis
    M Chaswal
    Department of Physiology, Vardhaman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
    Physiol Res 61:135-44. 2012
    ..However, autonomic dysregulation especially following chronic L-NAME appears to be partly angiotensin dependent...
  55. pmc Overt and latent cardiac effects of ozone inhalation in rats: evidence for autonomic modulation and increased myocardial vulnerability
    Aimen K Farraj
    Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 120:348-54. 2012
    ..Ozone (O₃) is a well-documented respiratory oxidant, but increasing epidemiological evidence points to extrapulmonary effects, including positive associations between ambient O₃ concentrations and cardiovascular morbidity and mortality...
  56. ncbi Cardiac autonomic function and cardiovascular response to exercise in patients with chronic obstructive pulmonary disease
    Arnoldus J R VAN Gestel
    Department of Pneumology, University Hospital Ruhrlandklinik, Essen, Germany
    COPD 9:160-5. 2012
    ..Chronic obstructive pulmonary disease (COPD) is associated with impaired exercise tolerance, but it has not been established to what extent cardiac autonomic function impacts on exercise capacity...
  57. ncbi The role of the chemical burns caused by hydroxide ion in the toxicity of dermal exposure to tetramethylammonium ion in a rat model
    Chen Long Wu
    Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Burns 38:1051-7. 2012
    ....
  58. ncbi Psychotropic medication use in children with autism in the Kentucky Medicaid population
    P Gail Williams
    Weisskopff Child Evaluation Center, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Clin Pediatr (Phila) 51:923-7. 2012
    ..High PTD use in children between 1 and 5 years is particularly of concern and may reflect perceived inadequacies of comprehensive educational/behavioral services for these children...
  59. ncbi Modulation of rate by autonomic agonists in SAN cells involves changes in diastolic depolarization and the pacemaker current
    Annalisa Bucchi
    University of Milano, Department of Biomolecular Sciences and Biotechnology, Laboratory of Molecular Physiology and Neurobiology, Via Celoria 26, 20133 Milano, Italy
    J Mol Cell Cardiol 43:39-48. 2007
    ..3% and Iso, +47.6%) and not of TOP. We conclude that rate-related changes in the EDD induced by autonomic agonists are mediated by I(f) and not by processes involving SR Ca2+ transients...
  60. ncbi Clinical significance of junctional pacemaker automaticity in patients with sick sinus syndrome
    H Ogawa
    First Department of Internal Medicine, Kobe University, School of Medicine, Japan
    Jpn Circ J 55:1165-73. 1991
    ..Organic impairment should affect conductivity as well as automaticity in the AV junction...
  61. ncbi Role of adrenergic and cholinergic mediators in gastric mucus phospholipid secretion
    S Sengupta
    Research Center, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark 07103 2400
    Biochem Int 24:1145-53. 1991
    ..1-fold enrichment in this phospholipid occurred with pilocarpine. The results, for the first time, demonstrate the involvement of neural mediators in the regulation of phospholipid secretion in gastric mucus...
  62. ncbi Effects of autonomic agonists and immunomodulatory cytokines on polymeric immunoglobulin receptor expression by cultured rat and human salivary and colonic cell lines
    S W Cox
    Salivary Research Unit, King s College London Dental Institute at Guy s, King s College and St Thomas Hospitals, London, UK
    Arch Oral Biol 52:411-6. 2007
    ..Our aim here was to determine whether autonomic agonists and cytokines present in Sjögren's-affected glands can up-regulate salivary cell plgR expression...
  63. ncbi Age and gender difference in ST height at rest and after double autonomic blockade in normal adults
    Susanne Endres
    Division of Cardiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Ann Noninvasive Electrocardiol 11:253-8. 2006
    ..The exact mechanisms that cause ST height to be greater in young men are not yet completely understood. The purpose of the present study was to determine whether autonomic tone is responsible for age and gender differences in ST height...
  64. ncbi Power spectrum analysis and cardiovascular morbidity in anxiety disorders
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 4600, Beer Sheva, Israel
    Auton Neurosci 128:1-8. 2006
    ..The authors call for further studies, especially in patients with co-existing anxiety disorders and heart disease, incorporating assessment of HRV...
  65. ncbi Ability of short-time Fourier transform method to detect transient changes in vagal effects on hearts: a pharmacological blocking study
    Kaisu Martinmäki
    KIHU Research Institute for Olympic Sports, and Department of Biology of Physical Activity, University of Jyvaskyla, FI 40014 Jyvaskyla, Finland
    Am J Physiol Heart Circ Physiol 290:H2582-9. 2006
    ....
  66. ncbi Medication effects on metabolic rate: a systematic review (part 2)
    Roland N Dickerson
    University of Tennessee Health Sciences Center, Memphis 38163, USA
    J Am Diet Assoc 105:1002-9. 2005
  67. ncbi Biological pacemaker created by fetal cardiomyocyte transplantation
    Guosheng Lin
    Department of Cardiology, Renmin Hospital of Wuhan University, Jiefang Road, 238, Wuhan, 430060, People s Republic of China
    J Biomed Sci 12:513-9. 2005
    ..The aim of this study was to investigate the feasibility of an alternative approach to electronic pacemaker by using spontaneously excitable cell grafts as a biological pacemaker in a large animal model of complete atrioventricular block...
  68. ncbi Long posterior ciliary arterial blood flow and systemic blood pressure
    H Okubo
    Dean A McGee Eye Institute, Oklahoma City, OK 73104
    Invest Ophthalmol Vis Sci 31:819-26. 1990
    ..There are vasoconstrictive alpha-1 and alpha-2 adrenoceptors and vasodilative muscarinic receptors in the rabbit ocular vascular tree...
  69. ncbi Adrenergic and cholinergic regulation of gastric mucus phospholipid secretion
    S Sengupta
    Research Center, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark 07103 2400
    Scand J Gastroenterol 27:29-32. 1992
    ..1-fold enrichment in this phospholipid occurred with pilocarpine. The results demonstrate the involvement of neural mediators in the regulation of phospholipid secretion in gastric mucus...
  70. ncbi The rat external urethral sphincter an in vitro model to evaluate the activity of drugs on the smooth and striated components of the urinary bladder outlet
    M Parlani
    Department of Pharmacology, Menarini Ricerche Sud, Pomezia, Roma, Italy
    J Pharmacol Toxicol Methods 28:85-90. 1992
    ....
  71. ncbi Characterization of the peripheral action of neuropeptide K on the rat cardiovascular system
    A Decarie
    Departement de Physiologie, Faculte de Medecine, Universite de Montreal, Que, Canada
    Eur J Pharmacol 213:125-31. 1992
    ..Thus, NPK is considered as the most potent biologically active tachykinin so far described on the rat cardiovascular system...
  72. ncbi Modulation of alcohol and nicotine responses through the endogenous opioid system
    Eva Drews
    Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany
    Prog Neurobiol 90:1-15. 2010
    ..This review summarizes pharmacological and genetic studies in animal models and in humans that have addressed the role of specific opioid peptides and receptors in various stages of the addiction process...
  73. ncbi Antiadrenergic and hemodynamic effects of ranolazine in conscious dogs
    Gong Zhao
    Department of Biology, Gilead Sciences Palo Alto, Palo Alto, CA, USA
    J Cardiovasc Pharmacol 57:639-47. 2011
    ..Ranolazine, at plasma concentrations <10 μM and in conscious dogs with intact autonomic regulation, had minimal antiadrenergic (α and β) effects...
  74. ncbi Mechanism of the pressor response to intraperitoneal injection of bradykinin in guinea pigs
    J F Beauchamp
    Centre de Recherche, Hotel Dieu de Quebec, Canada
    Peptides 12:513-21. 1991
    ....
  75. ncbi [The function of autonomic receptors in canine ureteral smooth muscle]
    T Yamaguchi
    Department of Urology, Akita University School of Medicine
    Nihon Hinyokika Gakkai Zasshi 82:1642-8. 1991
    ....
  76. ncbi Efficacy of venlafaxine, medroxyprogesterone acetate, and cyproterone acetate for the treatment of vasomotor hot flushes in men taking gonadotropin-releasing hormone analogues for prostate cancer: a double-blind, randomised trial
    Jacques Irani
    Urology Unit, University Hospital, Poitiers, France
    Lancet Oncol 11:147-54. 2010
    ..We designed a randomised double-blind trial to compare the efficacy of three drugs, each of which has proven effective for preventing hot flushes in previous studies...
  77. pmc Autonomic drugs and the accommodative system in rhesus monkeys
    Lisa A Ostrin
    University of Houston College of Optometry, 505 J Davis Armistead Bldg, Houston, TX 77204, USA
    Exp Eye Res 90:104-12. 2010
    ..Low dose echothiophate had significant effects on pupil diameter and resting refraction, with only small effects on the dynamics of the accommodative response...
  78. ncbi Development factors in the contractile response of the rabbit bladder to both autonomic and non-autonomic agents
    S A Zderic
    Division of Urology, Children s Hospital of Philadelphia, PA
    Pharmacology 41:119-23. 1990
    ....
  79. ncbi Evaluation and management of autonomic nervous system disorders
    Caroline M Klein
    Department of Neurology, The University of North Carolina School of Medicine, 3114 Bioinformatics, Campus Box 7025, Chapel Hill, NC 27599 7025, USA
    Semin Neurol 28:195-204. 2008
    ..These advances include testing for ganglionic acetylcholine receptor antibody in patients with suspected autoimmune autonomic neuropathy and use of pyridostigmine for treatment of patients with orthostatic hypotension or tachycardia...
  80. ncbi Chronic istaroxime improves cardiac function and heart rate variability in cardiomyopathic hamsters
    Pietro Lo Giudice
    Research and Development, Pharmacology Department, Sigma Tau Industrie Farmaceutiche Riunite S p A, Via Pontina Km 30 400, 00040, Pomezia, Rome, Italy
    Cardiovasc Drugs Ther 25:133-8. 2011
    ..The aim of present study is to assess the effect of chronic istaroxime treatment on cardiac function and heart rate variability in Bio TO.2 Syrian hamster model of progressive heart failure...
  81. ncbi Effects of saw palmetto extract on micturition reflex of rats and its autonomic receptor binding activity
    Tomomi Oki
    Department of Biopharmacy and Center of Excellence Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    J Urol 173:1395-9. 2005
    ..We examined the effects of saw palmetto extract (SPE) on the rat micturition reflex and on autonomic receptors in the lower urinary tract...
  82. ncbi Chondroitinase ABCI improves locomotion and bladder function following contusion injury of the rat spinal cord
    Anthony O Caggiano
    Acorda Therapeutics, Inc, Hawthorne, New York 10532, USA
    J Neurotrauma 22:226-39. 2005
    ....
  83. ncbi Modulation of an idioventricular rhythm by vagal tone
    M B Waxman
    Department of Medicine, University of Toronto, Ontario, Canada
    J Am Coll Cardiol 11:1052-60. 1988
    ..It offers the first clear proof that a ventricular pacemaker can be innervated and controlled by the vagus nerve and provides its location...
  84. ncbi Contrasting actions of pressor agents in severe autonomic failure
    J Jordan
    Clinical Research Center, Franz Volhard Clinic, Berlin, Germany
    Am J Med 105:116-24. 1998
    ..Orthostatic hypotension is the most disabling symptom of autonomic failure. The choice of a pressor agent is largely empiric, and it would be of great value to define predictors of a response...
  85. ncbi Effects of autonomic blockade on the hypertensive response of the fetus to hyperosmolality
    N M Kingsford
    School of Physiology and Pharmacology, University of New South Wales, Kensington, Australia
    Clin Exp Pharmacol Physiol 16:873-83. 1989
    ..Thus changes that threaten maintenance of fetal blood volume seem to induce increased solute and water transport across the placenta or from the extracorporeal fluid compartments...
  86. ncbi Mechanical responses of the rat uterus, cervix, and bladder to stimulation of hypogastric and pelvic nerves in vivo
    S Sato
    Department of Obstetrics and Gynecology, Yamagata University School of Medicine, Japan
    Biol Reprod 40:209-19. 1989
    ..Uterine and cervical responses to either hypogastric or pelvic nerve stimulation were markedly reduced late in pregnancy and reappeared within 7 days after delivery...
  87. ncbi Effect of thyroxine on urinary bladder autonomic receptor densities and contractility
    M E Hess
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104 6084
    Pharmacology 46:248-53. 1993
    ....
  88. ncbi Effects of age on urinary bladder function in the male rat
    A L Chun
    Ohio State University College of Pharmacy, Columbus
    J Urol 141:170-3. 1989
    ..In summary, while in vivo micturition clearly changes with age, the in vitro contractility of the bladders to autonomic agents did not...
  89. ncbi Effects of long-term treatment with estrogen and progesterone on in vitro muscle responses of the female rabbit urinary bladder and urethra to autonomic drugs and nerve stimulation
    J Ekstrom
    Department of Pharmacology, University of Goteborg, Lund, Sweden
    J Urol 150:1284-8. 1993
    ..The present animal study gives support for the use of estrogen in the therapy of stress incontinence and, further, it provides no objections to the use of progesterone in combination with estrogen in this condition...
  90. ncbi Relaxatory responses of canine proximal stomach to esophageal and duodenal distension. Importance of vagal pathways
    F De Ponti
    Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905
    Dig Dis Sci 34:873-81. 1989
    ..We conclude that both esophageal and duodenal distension elicit gastric relaxation by a noncholinergic vagal mechanism.(ABSTRACT TRUNCATED AT 250 WORDS)..
  91. ncbi Cholinergic stimulation of progesterone and estradiol secretion by human granulosa cells cultured in serum-free medium
    J Bodis
    University Medical School of Pecs, Hungary
    Gynecol Endocrinol 7:83-7. 1993
    ..The results suggest that cholinergic action on steroid production by human GCs is mediated through the muscarinic route, and cholinergic neurotransmission may have a physiological significance in the intra-ovarian regulatory pathways...
  92. ncbi Pumiliotoxin B-like alkaloid in extracts of the skin of the Australian myobatrachid frog Pseudophryne coriacea: effects on the systemic blood pressure of experimental animals and the rat heart
    G F Erspamer
    Institute of Medical Pharmacology III, University of Rome La Sapienza, Italy
    Neuropharmacology 28:319-28. 1989
    ..This suggests that activation of sodium channels may play a role in the mechanism of action of PS. However, the exact nature of ionic flux(es)influenced by the extract of frog skin remains to be established...
  93. ncbi Surgical procedure for the cure of atrioventricular junctional ("AV node") reentrant tachycardia: anatomic and electrophysiologic effects of dissection of the anterior atrionodal connections in a canine model
    M A McGuire
    Cardiology Department, Westmead Hospital, Sydney, New South Wales, Australia
    J Am Coll Cardiol 24:784-94. 1994
    ..This study was undertaken to examine the electrophysiologic and anatomic effects of a surgical procedure that cures the anterior (common) type of atrioventricular (AV) junctional reentrant tachycardia...
  94. ncbi Iontophoretic study of adrenergic and cholinergic skin vessel reactivity in normal ageing and Alzheimer's disease
    R Hörnqvist
    University of Umea, Sweden
    Gerontology 33:374-9. 1987
    ..Furthermore, increasing age did not seem to significantly influence the cutaneous responses in mentally healthy controls. Thus, a reduced peripheral adrenergic reactivity was observed in the patients suffering from AD...
  95. ncbi Dopamine-induced coronary effects in the dog heart attributed to beta- and alpha-adrenergic mechanisms
    G Rabloczky
    Institute of Drug Research, Budapest, Hungary
    Arch Int Pharmacodyn Ther 293:109-26. 1988
    ..However, undefined after-effects provoked by i.c. DA, may be connected with specific dopaminergic effects...
  96. ncbi Autonomic regulation of cardiac chloride current
    K Ono
    Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Jpn J Physiol 44:S193-8. 1994
    ..cGMP might contribute to the post-ACh rebound phenomenon by facilitating the beta-stimulation...
  97. ncbi Adrenergic modulation of gastric stress pathology in rats: a cholinergic link
    A Ray
    Department of Psychology, St Francis Xavier University, Antigonish, Nova Scotia, Canada
    J Auton Nerv Syst 20:265-8. 1987
    ..The results suggest a cholinergic role in the adrenergic modulation of gastric stress pathology...
  98. ncbi Cardiovascular responses to amitraz in the presence of autonomic antagonists and agonists
    L K Cullen
    School of Veterinary Studies, Murdoch University, Western Australia
    Arch Int Pharmacodyn Ther 296:45-56. 1988
    ..It is possible that amitraz exerts its cardiovascular effects by stimulation of alpha 2-adrenoceptors and has some similarities to clonidine and xylazine in action...
  99. ncbi Effects of diproteverine, a new calcium antagonist on sinoatrial node and atrioventricular conduction in conscious unsedated dogs
    J P Kantelip
    Laboratoire de Pharmacologie Medicale, INSERM U195, Faculte de Medecine, Clermont Ferrand, France
    J Cardiovasc Pharmacol 12:432-7. 1988
    ....
  100. ncbi The effects of upper incisor separation on the submandibular and sublingual glands of rats
    K Kamogashira
    Department of Orthodontics, Fukuoka Dental College, Japan
    J Dent Res 67:602-10. 1988
    ..However, the submandibular and sublingual glands completely recovered after removal of the orthodontic appliance...
  101. ncbi Inhibition of salivary secretion by lipopolysaccharide: possible role of prostaglandins
    A Lomniczi
    Catedra de Fisiologia, Faculta de Odontología, Universidad de Buenos Aires, 1122, Argentina
    Am J Physiol Endocrinol Metab 281:E405-11. 2001
    ..Diminished salivary secretion produces poor oral health; thus the use of COX-2 inhibitors to counteract the effects of inhibited salivation should be considered...

Research Grants14

  1. Development of fMRI Methods for Neuropharmacology
    Shi Jiang Li; Fiscal Year: 2007
    ..Aim 1, we will determine and characterize the systemic cardiovascular effects induced by anesthetic and autonomic agents on the fMRI blood oxygenation level dependent (BOLD) response in the rat brain produced by forepaw ..
  2. AUTONOMIC RECEPTORS OF THE PULMONARY VASCULATURE
    CARL BUCKNER; Fiscal Year: 1980
    ....
  3. CELL MECHANISMS CONTROLLING URINARY BLADDER CONTINENCE
    Gordon Anderson; Fiscal Year: 1980
    ..organ baths in which 45Ca will be employed to measure changes in Ca2 ion uptake and efflux as influenced by autonomic agents, prostaglandin and several naturally occurring peptides...
  4. VIP-induced gene expression in colonic smooth muscle cells
    Sushil K Sarna; Fiscal Year: 2010
    ..abstract_text> ..
  5. Personal Electrocardiographic Expert System
    Vladimir Shusterman; Fiscal Year: 2007
    ..Safety and regulatory testing will be completed, and a 51O K application will be submitted to the FDA. [unreadable] [unreadable]..
  6. Exocytosis and Coupled Endocytosis in Neuroendocrine Cells
    JOHN DAVID CASTLE; Fiscal Year: 2010
    ..4) Exocytosis and exo- endocytic coupling will be analyzed in chromaffin cells lacking SCAMP1 using amperometry, tracer uptake, and electron microscopy to analyze defects thought to be related to chromaffin cell physiology. ..
  7. REGULATION OF EXOCYTOSIS IN MAST CELLS
    J Castle; Fiscal Year: 2004
    ..abstract_text> ..
  8. Mechanisms of Depression and Cardiovascular Pathology
    ANGELA GRIPPO; Fiscal Year: 2003
    ..abstract_text> ..
  9. MEMBRANE FUNCTION IN PAROTID SECRETORY MECHANISMS
    J Castle; Fiscal Year: 2005
    ..Taken together, these studies, which originated in response to an NIDCR program announcement, reflect part of an ongoing commitment to advance basic understanding at the interface of molecular cell biology and oral physiology. ..
  10. NEUROIMAGING OF INHIBITION & STIMULANT RESPONSE IN ADHD
    Steven Pliszka; Fiscal Year: 2004
    ..5) We will control for effects of gender and age, in particular girls with ADHD may not show the same neurobiological mechanisms as boys. ..
  11. Social Isolation, Behavior, and Autonomic Function
    ANGELA GRIPPO; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  12. PATHWAYS AND REGULATION OF SALIVARY SECRETION
    J Castle; Fiscal Year: 2003
    ..The findings may be broadly applicable in exocrine secretory cells. ..
  13. Gordon Conference, Salivary Glands & Exocrine Secretion
    J Castle; Fiscal Year: 2003
    ..It is the goal of the organizing team to encourage both growth and enrichment of this important field and to stimulate new strategies for studying salivary glands. ..