hypnotics and sedatives

Summary

Summary: Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.

Top Publications

  1. ncbi Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial
    Richard R Riker
    University of Vermont College of Medicine, USA
    JAMA 301:489-99. 2009
  2. pmc A review of the physiological effects of alpha2-agonists related to the clinical use of medetomidine in small animal practice
    Melissa D Sinclair
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1
    Can Vet J 44:885-97. 2003
  3. pmc Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits
    Jennifer Glass
    University of Toronto, Department of Pharmaceutical Sciences, Toronto, ON, Canada M5S 2S2
    BMJ 331:1169. 2005
  4. ncbi Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials
    Stephan M Jakob
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Bern, Switzerland
    JAMA 307:1151-60. 2012
  5. ncbi A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial
    Thomas Strøm
    Department of Anesthesia and Intensive Care Medicine, Odense University Hospital, University of Southern Denmark, Denmark
    Lancet 375:475-80. 2010
  6. ncbi Comparative meta-analysis of pharmacotherapy and behavior therapy for persistent insomnia
    Michael T Smith
    Department of Psychiatry, Johns Hopkins University, Baltimore, MD 21287 7218, USA
    Am J Psychiatry 159:5-11. 2002
  7. ncbi Psychological and behavioral treatment of insomnia:update of the recent evidence (1998-2004)
    Charles M Morin
    Universite Laval, Quebec, Canada
    Sleep 29:1398-414. 2006
  8. ncbi Effects of prolonged-release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers
    S Otmani
    FORENAP Institute for Research in Neurosciences, Rouffach, France
    Hum Psychopharmacol 23:693-705. 2008
  9. ncbi Acupuncture for treatment of insomnia in patients with traumatic brain injury: a pilot intervention study
    Felise S Zollman
    Departments of Physical Medicine and Rehabilitation and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Head Trauma Rehabil 27:135-42. 2012
  10. ncbi Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: a randomized controlled study
    Iyad Khamaysi
    Department of Gastroenterology, Rambam Medical Center, Haifa, Israel
    J Hepatol 54:72-7. 2011

Detail Information

Publications378 found, 100 shown here

  1. ncbi Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial
    Richard R Riker
    University of Vermont College of Medicine, USA
    JAMA 301:489-99. 2009
    ..Gamma-aminobutyric acid receptor agonist medications are the most commonly used sedatives for intensive care unit (ICU) patients, yet preliminary evidence indicates that the alpha(2) agonist dexmedetomidine may have distinct advantages...
  2. pmc A review of the physiological effects of alpha2-agonists related to the clinical use of medetomidine in small animal practice
    Melissa D Sinclair
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1
    Can Vet J 44:885-97. 2003
    ..The literature was searched in Pubmed, Medline, Agricola, CAB direct, and Biological Sciences...
  3. pmc Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits
    Jennifer Glass
    University of Toronto, Department of Pharmaceutical Sciences, Toronto, ON, Canada M5S 2S2
    BMJ 331:1169. 2005
    ..To quantify and compare potential benefits (subjective reports of sleep variables) and risks (adverse events and morning-after psychomotor impairment) of short term treatment with sedative hypnotics in older people with insomnia...
  4. ncbi Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials
    Stephan M Jakob
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Bern, Switzerland
    JAMA 307:1151-60. 2012
    ..Dexmedetomidine, an α(2)-agonist available for ICU sedation, may reduce the duration of mechanical ventilation and enhance patient comfort...
  5. ncbi A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial
    Thomas Strøm
    Department of Anesthesia and Intensive Care Medicine, Odense University Hospital, University of Southern Denmark, Denmark
    Lancet 375:475-80. 2010
    ..We aimed to establish whether duration of mechanical ventilation could be reduced with a protocol of no sedation versus daily interruption of sedation...
  6. ncbi Comparative meta-analysis of pharmacotherapy and behavior therapy for persistent insomnia
    Michael T Smith
    Department of Psychiatry, Johns Hopkins University, Baltimore, MD 21287 7218, USA
    Am J Psychiatry 159:5-11. 2002
    ..The authors conducted a quantitative review of the literature on the outcome of the two treatments to compare the short-term efficacy of pharmacotherapy and behavioral therapy in primary insomnia...
  7. ncbi Psychological and behavioral treatment of insomnia:update of the recent evidence (1998-2004)
    Charles M Morin
    Universite Laval, Quebec, Canada
    Sleep 29:1398-414. 2006
    ..As with the original paper, this review was conducted by a task force commissioned by the American Academy of Sleep Medicine in order to update its practice parameters on psychological and behavioral therapies for insomnia...
  8. ncbi Effects of prolonged-release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers
    S Otmani
    FORENAP Institute for Research in Neurosciences, Rouffach, France
    Hum Psychopharmacol 23:693-705. 2008
    ..Because hypnotics result in impairments of various cognitive skills, it is important to examine the cognitive effects associated with the use of PR-M...
  9. ncbi Acupuncture for treatment of insomnia in patients with traumatic brain injury: a pilot intervention study
    Felise S Zollman
    Departments of Physical Medicine and Rehabilitation and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Head Trauma Rehabil 27:135-42. 2012
    ..To assess the efficacy of acupuncture in treating insomnia in traumatic brain injury (TBI) survivors as compared to medication, to determine whether acupuncture has fewer cognitive and affective adverse effects than does medication...
  10. ncbi Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: a randomized controlled study
    Iyad Khamaysi
    Department of Gastroenterology, Rambam Medical Center, Haifa, Israel
    J Hepatol 54:72-7. 2011
    ..The aim of this study is to determine whether the use of propofol, for upper endoscopy in patients with cirrhosis, precipitates sub-clinical HE...
  11. ncbi Early intensive care sedation predicts long-term mortality in ventilated critically ill patients
    Yahya Shehabi
    University of New South Wales Clinical School and Prince of Wales Hospital, Program of Acute Care, Department of Intensive Care Services, Barker Street, Randwick, NSW 2031, Australia
    Am J Respir Crit Care Med 186:724-31. 2012
    ..Choice and intensity of early (first 48 h) sedation may affect short- and long-term outcome...
  12. ncbi Propofol sedation for upper gastrointestinal endoscopy in patients with liver cirrhosis as an alternative to midazolam to avoid acute deterioration of minimal encephalopathy: a randomized, controlled study
    Andrea Riphaus
    Department of Internal Medicine I, Gastroenterology and Interventional Endoscopy, Hospital Siloah, Hannover, Germany
    Scand J Gastroenterol 44:1244-51. 2009
    ..The aim of this randomized, controlled study was to assess whether the use of the short-acting propofol as a sedative for GI endoscopy could prevent the exacerbation of minimal HE in patients with liver cirrhosis...
  13. ncbi Risk of fractures requiring hospitalization after an initial prescription for zolpidem, alprazolam, lorazepam, or diazepam in older adults
    William D Finkle
    Consolidated Research, Inc, Los Angeles, California, USA
    J Am Geriatr Soc 59:1883-90. 2011
    ..To determine whether zolpidem is a safer alternative to benzodiazepines...
  14. ncbi Sedation and analgesia in the mechanically ventilated patient
    Shruti B Patel
    Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Illinois, USA
    Am J Respir Crit Care Med 185:486-97. 2012
    ..In this article, we review advances in the field of ICU sedation to provide an up-to-date perspective on management of the mechanically ventilated ICU patient...
  15. ncbi Long-term sedation in intensive care unit: a randomized comparison between inhaled sevoflurane and intravenous propofol or midazolam
    Malcie Mesnil
    Department of Anesthesiology and Critical Care Lapeyronie DAR A, Montpellier I University and Montpellier University Lapeyronie Hospital, Institut National de la Sante et de la Recherche Medicale INSERM, Equipe soutenue par la Région et l Inserm ERI 25, route de Ganges, 34295 Montpellier, Cedex 5, France
    Intensive Care Med 37:933-41. 2011
    ..To evaluate efficacy and adverse events related to inhaled sevoflurane for long-term sedation compared with standard intravenous (i.v.) sedation with propofol or midazolam...
  16. ncbi Sleep maintenance insomnia: strengths and weaknesses of current pharmacologic therapies
    Russell P Rosenberg
    Northside Hospital Sleep Medicine Institute, Atlanta, GA, USA
    Ann Clin Psychiatry 18:49-56. 2006
    ..When insomnia is recognized, considerable emphasis has been placed on improving sleep onset; however, there is growing evidence that improving sleep maintenance is an equally important treatment goal...
  17. ncbi A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder
    U Koetter
    Max Zeller Sohne AG, CH 8590 Romanshorn, Switzerland
    Phytother Res 21:847-51. 2007
    ..The result underlined the plausibility for adding hops extract to the valerian extract...
  18. pmc Calcium/calmodulin-dependent protein kinase II mediates hippocampal glutamatergic plasticity during benzodiazepine withdrawal
    Guofu Shen
    Department of Physiology and Pharmacology, University of Toledo College of Medicine, Health Science Campus, Toledo, OH 43614, USA
    Neuropsychopharmacology 35:1897-909. 2010
    ....
  19. pmc Drug Burden Index and physical function in older Australian men
    Danijela Gnjidic
    Department of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, Sydney, Australia
    Br J Clin Pharmacol 68:97-105. 2009
    ..The Drug Burden Index is a measure of total exposure to anticholinergic and sedative medications that incorporates the principles of dose-response and maximal effect...
  20. ncbi The changing face of teenage drug abuse--the trend toward prescription drugs
    Richard A Friedman
    Psychopharmacology Clinic at Weill Cornell Medical College, New York, USA
    N Engl J Med 354:1448-50. 2006
  21. ncbi Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats
    Takumi Taniguchi
    Department of Emergency and Critical Care Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Crit Care Med 32:1322-6. 2004
    ..The aim of this study was to document the effects of a new sedative agent, dexmedetomidine, on the mortality rate and inflammatory responses to endotoxin-induced shock in rats...
  22. ncbi Mortality hazard associated with anxiolytic and hypnotic drug use in the National Population Health Survey
    Geneviève Belleville
    Universite Laval, Quebec, Canada
    Can J Psychiatry 55:558-67. 2010
    ..It was hypothesized that anxiolytic and hypnotic drug use would be associated with an elevated mortality hazard...
  23. ncbi Associations between drug burden index and falls in older people in residential aged care
    Nicholas M Wilson
    Kolling Institute of Medical Research, Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
    J Am Geriatr Soc 59:875-80. 2011
    ....
  24. pmc Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial
    Pratik P Pandharipande
    Anesthesiology Service, VA TN Valley Health Care System, Nashville, TN 37212 2637, USA
    Crit Care 14:R38. 2010
    ....
  25. ncbi Bispectral index-guided sedation with dexmedetomidine in intensive care: a prospective, randomized, double blind, placebo-controlled phase II study
    Andreas E Triltsch
    Department of Anesthesiology and Intensive Care Medicine, Benjamin Franklin Medical Center, Free University of Berlin, Germany
    Crit Care Med 30:1007-14. 2002
    ..To compare dexmedetomidine vs. placebo with respect to the amount of additional propofol and morphine used for bispectral index-guided sedation and analgesia in mechanically ventilated, intensive care patients after surgery...
  26. ncbi Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery
    Jose R Maldonado
    Dept of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd, Suite 2317, Stanford, CA 94305 5546, USA
    Psychosomatics 50:206-17. 2009
    ..Delirium is a neurobehavioral syndrome caused by the transient disruption of normal neuronal activity secondary to systemic disturbances...
  27. ncbi Propofol alone titrated to deep sedation versus propofol in combination with opioids and/or benzodiazepines and titrated to moderate sedation for colonoscopy
    Megan E VanNatta
    Department of Medicine, Division of Gastroenterology, Indiana University School of Medicine, Indianapolis Indiana 46202, USA
    Am J Gastroenterol 101:2209-17. 2006
    ..Propofol in combination with opioids and/or benzodiazepines can be titrated to moderate sedation, which might be safer...
  28. ncbi Diagnosis and treatment of chronic insomnia: a review
    Ruth M Benca
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    Psychiatr Serv 56:332-43. 2005
    ..Insomnia has high prevalence rates and is associated with significant personal and socioeconomic burden, yet it remains largely underrecognized and inadequately treated...
  29. ncbi A drug burden index to define the functional burden of medications in older people
    Sarah N Hilmer
    Laboratory of Clinical Investigation and Clinical Research Branch, Intramural Research Program, National Institute on Aging, Baltimore and Bethesda, MD, USA
    Arch Intern Med 167:781-7. 2007
    ..We developed an index to determine drug burden based on pharmacologic principles. We evaluated the relationship of this index to physical and cognitive performance apart from disease indication...
  30. ncbi Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats
    Kimberly D Statler
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurotrauma 23:97-108. 2006
    ..Furthermore, the choice of post-injury sedation and analgesia could have important implications on attempts to translate novel therapies from bench to field or bedside...
  31. ncbi Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive caret
    R M Venn
    Department of Anaesthesia and Intensive Care, Worthing Hospital, West Sussex, UK
    Br J Anaesth 88:669-75. 2002
    ..The pharmacokinetics of the alpha-2 adrenoceptor agonist dexmedetomidine were studied in 10 patients requiring postoperative sedation and mechanical ventilation in the intensive care unit (ICU), and compared with previous volunteer data...
  32. ncbi Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation
    Esko Ruokonen
    Department of Anesthesiology and Intensive Care Medicine, Kuopio University Hospital, P O Box 1777, 70211, Kuopio, Finland
    Intensive Care Med 35:282-90. 2009
    ..To compare dexmedetomidine (DEX) with standard care (SC, either propofol or midazolam) for long-term sedation in terms of maintaining target sedation and length of intensive care unit (ICU) stay...
  33. ncbi Use of anxiolytic or hypnotic drugs and total mortality in a general middle-aged population
    Anne Margrethe Hausken
    Division of Epidemiology, Norwegian Institute of Public Health, Nydalen, Oslo, Norway
    Pharmacoepidemiol Drug Saf 16:913-8. 2007
    ..The aim of the study was to evaluate the effect of the consumption of anxiolytic or hypnotic drugs on total mortality in a general population...
  34. pmc Effectiveness of non-benzodiazepine hypnotics in treatment of adult insomnia: meta-analysis of data submitted to the Food and Drug Administration
    Tania B Huedo-Medina
    Department of Allied Health Sciences, University of Connecticut, 358 Mansfield Road U 2101, Storrs, CT 06269 2101, USA
    BMJ 345:e8343. 2012
    ..To investigate the effectiveness of non-benzodiazepine hypnotics (Z drugs) and associated placebo responses in adults and to evaluate potential moderators of effectiveness in a dataset used to approve these drugs...
  35. ncbi The use of the Behavioral Pain Scale to assess pain in conscious sedated patients
    Sabine J G M Ahlers
    Department of Clinical Pharmacy, St Antonius Hospital, PO Box 2500, 3440 EM Nieuwegein, The Netherlands
    Anesth Analg 110:127-33. 2010
    ..Additionally, in conscious sedated patients, the combination of the BPS and the patient-rated Verbal Rating Scale (VRS-4) was evaluated...
  36. ncbi Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis
    Muhittin Tasdogan
    Department of Anaesthesiology and Reanimation, Trakya University Medical Faculty, 22030 Edirne, Turkey
    J Clin Anesth 21:394-400. 2009
    ....
  37. ncbi Pharmacokinetics of orally administered melatonin in critically ill patients
    Giovanni Mistraletti
    Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Universita degli Studi di Milano, Milano, Italy
    J Pineal Res 48:142-7. 2010
    ....
  38. pmc Changes in sedation management in German intensive care units between 2002 and 2006: a national follow-up survey
    JORG MARTIN
    Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Hospital am Eichert, Eichertstrasse 3, 73035 Göppingen, Germany
    Crit Care 11:R124. 2007
    ..The aim of this study, conducted in 2006, was to find out whether changes in sedation management in German intensive care units took place in comparison with our survey from 2002...
  39. ncbi Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study
    Peter V Sackey
    Section of Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden
    Crit Care Med 36:801-6. 2008
    ..To compare memories from the intensive care unit (ICU) and short- and long-term psychological morbidity in patients after sedation with intravenous midazolam or inhaled isoflurane...
  40. pmc Closed-loop continuous infusions of etomidate and etomidate analogs in rats: a comparative study of dosing and the impact on adrenocortical function
    Joseph F Cotten
    Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 115:764-73. 2011
    ..In this study, we compared the effects of continuous infusions of etomidate, methoxycarbonyl etomidate, and carboetomidate on adrenocortical function in a rat model...
  41. ncbi Sedation assessment tool to score acute behavioural disturbance in the emergency department
    Leonie A Calver
    Discipline of Clinical Pharmacology, Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia
    Emerg Med Australas 23:732-40. 2011
    ..The objective of the study was to evaluate the effectiveness of the sedation assessment tool (SAT) in assessing patient response to treatment for acute behavioural disturbance (ABD)...
  42. ncbi Zolpidem for insomnia
    David J Greenblatt
    Tufts University School of Medicine, Department of Molecular Physiology and Pharmacology, 136 Harrison Avenue, Boston, MA 02111, USA
    Expert Opin Pharmacother 13:879-93. 2012
    ..The imidazopyridine derivative zolpidem , which acts as a benzodiazepine (BZ) receptor agonist, is the most widely prescribed hypnotic drug in the US...
  43. ncbi Meta-analysis of randomised controlled trials on daily sedation interruption for critically ill adult patients
    R Augustes
    Intensive Care Unit, Royal Perth Hospital and School of Population Health, University of Western Australia, Perth, Western Australia, Australia
    Anaesth Intensive Care 39:401-9. 2011
    ....
  44. ncbi Adverse events during monitored anesthesia care for GI endoscopy: an 8-year experience
    Massimo Agostoni
    Department of Anesthesiology, Vita Salute University of Milan, IRCCS H San Raffaele, Milan, Italy
    Gastrointest Endosc 74:266-75. 2011
    ..The importance of sedation during endoscopy is well established. There is no consensus about the best techniques for sedation, which specialist should perform it, and in which location...
  45. pmc The impact of a standardised intramuscular sedation protocol for acute behavioural disturbance in the emergency department
    Leonie A Calver
    Discipline of Clinical Pharmacology, University of Newcastle, New South Wales, Australia
    BMC Emerg Med 10:14. 2010
    ..Acute behavioural disturbance (ABD) is an increasing problem in emergency departments. This study aimed to determine the impact of a structured intramuscular (IM) sedation protocol on the duration of ABD in the emergency department...
  46. ncbi Sleep patterns and total mortality: a 12-year follow-up study in Japan
    M Kojima
    Department of Preventive Medicine, Nagoya University School of Medicine, Japan
    J Epidemiol 10:87-93. 2000
    ..89). These findings were almost unchanged after adjustment for sleep duration and other confounders. Poor self-reported quality of sleep seemed to be associated with an increased risk of mortality independently of sleep duration...
  47. ncbi Efficacy of bispectral index monitoring as an adjunct to propofol deep sedation for ERCP: a randomized controlled trial
    G A Paspatis
    Department of Gastroenterology, Benizelion General Hospital, Crete, Greece
    Endoscopy 41:1046-51. 2009
    ....
  48. ncbi Benzodiazepines revisited--will we ever learn?
    Malcolm Lader
    Addiction Research Centre, Institute of Psychiatry, King s College London, London, UK
    Addiction 106:2086-109. 2011
    ..It is a descriptive review based on the Okey Lecture delivered at the Institute of Psychiatry, King's College London, in November 2010...
  49. pmc Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest
    Philip E Empey
    Department of Pharmacy and Therapeutics, School of Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 40:1221-8. 2012
    ....
  50. ncbi Safe and effective sedation in endoscopic submucosal dissection for early gastric cancer: a randomized comparison between propofol continuous infusion and intermittent midazolam injection
    Shinsuke Kiriyama
    Department of Endoscopy, National Cancer Center Hospital, Tokyo, Japan
    J Gastroenterol 45:831-7. 2010
    ..The aim of this study was to compare the safety profiles and recovery scores propofol continuous infusion and intermittent midazolam (MDZ) injection as sedation for ESD...
  51. ncbi Early cognitive impairment after sedation for colonoscopy: the effect of adding midazolam and/or fentanyl to propofol
    Usha Padmanabhan
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia
    Anesth Analg 109:1448-55. 2009
    ..We sought to determine if the use of propofol alone results in less cognitive impairment at discharge than the use of propofol plus midazolam and/or fentanyl in patients presenting for elective outpatient colonoscopy...
  52. ncbi Pharmacological advances in the treatment of insomnia
    Sarah M Richey
    Mid Atlantic Permanente Medical Group, Fairfax, Virginia 22033, USA
    Curr Pharm Des 17:1471-5. 2011
    ....
  53. pmc Road traffic accidents and psychotropic medication use in The Netherlands: a case-control study
    Silvia Ravera
    Department of Pharmacotherapy and Pharmaceutical Care, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Br J Clin Pharmacol 72:505-13. 2011
    ..To examine the association between the use of commonly prescribed psychotropic medications and road traffic accident risk...
  54. pmc The efficacy of the COMFORT scale in assessing optimal sedation in critically ill children requiring mechanical ventilation
    Hyun Seung Jin
    Department of Pediatrics, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea
    J Korean Med Sci 22:693-7. 2007
    ..7 cases). The total duration of sedation (8.0 days vs. 11.5 days) also tended to decrease. These findings suggest that application of protocol-based sedation with the COMPORT scale may benefit children requiring mechanical ventilation...
  55. ncbi General practitioners' preferences for managing insomnia and opportunities for reducing hypnotic prescribing
    A Niroshan Siriwardena
    Faculty of Health, Life and Social Sciences, University of Lincoln, Brayford Pool, Lincoln, UK
    J Eval Clin Pract 16:731-7. 2010
    ..The aim of this study was to investigate GPs' management preferences for sleep problems and their awareness and perception of opportunities for improving care as well as reducing the use of benzodiazepines and Z drugs...
  56. pmc Chronic benzodiazepine-induced reduction in GABA(A) receptor-mediated synaptic currents in hippocampal CA1 pyramidal neurons prevented by prior nimodipine injection
    K Xiang
    Department of Physiology and Pharmacology, and the Cellular and Molecular Neurobiology Program, University of Toledo College of Medicine, Health Science Campus, 3000 Arlington Avenue, Mailstop 1008, Toledo, OH 43614, USA
    Neuroscience 157:153-63. 2008
    ....
  57. ncbi Induction of anaesthesia with either midazolam or propofol in rabbits premedicated with fentanyl/fluanisone
    M A Martinez
    Department of Clinical Veterinary Science, University of Bristol, Langford
    Vet Rec 164:803-6. 2009
    ..The quality of recovery was better in the propofol group than in the midazolam group...
  58. ncbi Current sedation practices: lessons learned from international surveys
    Sangeeta Mehta
    Medical Surgical Intensive Care Unit, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Crit Care Clin 25:471-88, vii-viii. 2009
    ....
  59. ncbi Comparative tolerability of newer agents for insomnia
    Gary Zammit
    Clinilabs, Inc, New York, New York, USA
    Drug Saf 32:735-48. 2009
    ....
  60. ncbi Tolerance and rebound insomnia with rapidly eliminated hypnotics: a meta-analysis of sleep laboratory studies
    C R Soldatos
    Department of Psychiatry, University of Athens, Greece
    Int Clin Psychopharmacol 14:287-303. 1999
    ....
  61. ncbi The risk of death: the confidential enquiry into perioperative small animal fatalities
    David C Brodbelt
    Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk, UK
    Vet Anaesth Analg 35:365-73. 2008
    ..To estimate the risks of anaesthetic and sedation-related mortality in companion animals in the UK. (The Confidential Enquiry into Perioperative Small Animal Fatalities, CEPSAF)...
  62. ncbi Effects of dexmedetomidine and propofol on lower esophageal sphincter and gastroesophageal pressure gradient in healthy volunteers
    Alparslan Turan
    Department of Outcomes Research, The Cleveland Clinic, Cleveland, OH 44195, USA
    Anesthesiology 112:19-24. 2010
    ..Therefore, the authors compared LESP and GEPG during dexmedetomidine and propofol sedation...
  63. ncbi The effects of dexmedetomidine on cardiac electrophysiology in children
    Gregory B Hammer
    Department of Anesthesiology, Lucile Packard Children s Hospital and Stanford University School of Medicine, Stanford, California, USA
    Anesth Analg 106:79-83, table of contents. 2008
    ..No data regarding the effects of DEX on the cardiac conduction system are available. We therefore aimed to characterize the effects of DEX on cardiac conduction in pediatric patients...
  64. ncbi Physical and cognitive performance and burden of anticholinergics, sedatives, and ACE inhibitors in older women
    Y J Cao
    National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    Clin Pharmacol Ther 83:422-9. 2008
    ....
  65. ncbi Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep
    E Huupponen
    Department of Clinical Neurophysiology, Tampere University Hospital, Finland
    Acta Anaesthesiol Scand 52:289-94. 2008
    ....
  66. pmc Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtype
    I Tobler
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 98:6464-9. 2001
    ..Because alpha1 GABA(A) receptors mediate the sedative action of Dz, our results provide evidence that the hypnotic effect of Dz and its EEG "fingerprint" can be dissociated from its sedative action...
  67. ncbi Sleep problems in general practice: a national survey of assessment and treatment routines of general practitioners in Norway
    Børge Sivertsen
    Department of Clinical Psychology, University of Bergen, Norway
    J Sleep Res 19:36-41. 2010
    ....
  68. ncbi The pharmacology of oversedation in mechanically ventilated adults
    John W Devlin
    Northeastern University School of Pharmacy, Boston, Massachusetts 02115, USA
    Curr Opin Crit Care 14:403-7. 2008
    ..To review pharmacological-related factors that affect the incidence of oversedation in mechanically ventilated adults...
  69. ncbi Postural instability and consequent falls and hip fractures associated with use of hypnotics in the elderly: a comparative review
    Herve Allain
    Laboratory of Experimental and Clinical Pharmacology, Pôle des Neurosciences and Centre Memory Resources Research CMRR, Faculty of Medicine, University of Rennes 1, Rennes Cedex, France
    Drugs Aging 22:749-65. 2005
    ..Comparative pharmacovigilance studies focused on the impact of hypnotics on postural stability are very much needed...
  70. ncbi High-dose dexmedetomidine for sedation in the intensive care unit: an evaluation of clinical efficacy and safety
    G Morgan Jones
    The Ohio State University, Columbus, OH, USA
    Ann Pharmacother 45:740-7. 2011
    ..However, to our knowledge, no study has assessed the clinical impact of doses greater than 0.7 μg/kg/h when compared to doses within the Food and Drug Administration--approved labeling...
  71. ncbi Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial
    Pratik P Pandharipande
    Department of Anesthesiology Division of Critical Care, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    JAMA 298:2644-53. 2007
    ..Dexmedetomidine induces sedation via different central nervous system receptors than the benzodiazepine drugs and may lower the risk of acute brain dysfunction...
  72. ncbi Attentional effects of noradrenaline vary with arousal level: selective activation of thalamic pulvinar in humans
    Jennifer T Coull
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London WC1N 3BG, UK
    Neuroimage 22:315-22. 2004
    ..Therefore, for the same level of sedation, the behavioural and anatomical attributes identifying the quality of sedation can vary...
  73. ncbi Limitations on the use of benzodiazepines in anxiety and insomnia: are they justified?
    M H Lader
    Institute of Psychiatry, University of London, UK
    Eur Neuropsychopharmacol 9:S399-405. 1999
    ..Other drug and non-drug therapies are available and have a superior risk benefit ratio in long-term use. It is concluded that benzodiazepines should be reserved for short-term use--up to 4 weeks--and in conservative dosage...
  74. ncbi Protocolized intensive care unit management of analgesia, sedation, and delirium improves analgesia and subsyndromal delirium rates
    Yoanna Skrobik
    Hopital Maisonneuve Rosemont, 5415 blvd de l Assomption, Montreal, QC, Canada H1T 2M4
    Anesth Analg 111:451-63. 2010
    ..We hypothesized that the likely reduction in iatrogenic coma would result in less delirium, because these 2 morbid conditions seem to be linked...
  75. ncbi Zolpidem: an update of its pharmacology, therapeutic efficacy and tolerability in the treatment of insomnia
    K J Holm
    Adis International Limited, Mairangi Bay, Auckland, New Zealand
    Drugs 59:865-89. 2000
    ..In this respect, it was comparable or superior to flunitrazepam and flurazepam and comparable to other benzodiazepines in patients with insomnia. Zolpidem appears to have a low potential for abuse...
  76. ncbi Insomnia and use of hypnotics: study of a French population
    M A Quera-Salva
    Service de Reanimation Medicale, Hopital Raymond Poincare, Garches, France
    Sleep 14:386-91. 1991
    ..One may question whether, in the French population, hypnotic prescription and intake are not responses to a social rather than a medical problem...
  77. ncbi Quality of psychomotor recovery after propofol sedation for routine endoscopy: a randomized and controlled study
    A Riphaus
    Department of Internal Medicine I Gastroenterology and Interventional Endoscopy, Siloah Hospital, Hanover, Germany
    Endoscopy 38:677-83. 2006
    ..Psychomotor recovery and driving skills before and after sedation were therefore assessed...
  78. ncbi Supraspinal anesthesia: behavioral and electroencephalographic effects of intracerebroventricularly infused pentobarbital, propofol, fentanyl, and midazolam
    Izabela Jugovac
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Anesthesiology 105:764-78. 2006
    ..The authors aimed to produce progressively increasing anesthetic depths, indicated by electro-encephalographic synchronization and behavioral change...
  79. ncbi Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: patient and clinician perceptions
    R M Venn
    Department of Anaesthesia and Intensive Care, Worthing Hospital, West Sussex, UK
    Br J Anaesth 87:684-90. 2001
    ..The rate pressure product is reduced in patients receiving dexmedetomidine, which may protect against myocardial ischaemia. Dexmedetomidine reduces the requirement for opioid analgesia...
  80. ncbi Sedative, analgesic, and cardiovascular effects of levomedetomidine alone and in combination with dexmedetomidine in dogs
    E Kuusela
    Department of Clinical Sciences, University of Helsinki, Finland
    Am J Vet Res 62:616-21. 2001
    ..Further studies are needed to confirm the clinical importance of the effects of levomedetomidine in dogs...
  81. ncbi Analgesia and sedation during mechanical ventilation in neonates
    J V Aranda
    Pediatric Pharmacology Research Unit Network, Wayne State University and Children s Hospital of Michigan, Detroit, USA
    Clin Ther 27:877-99. 2005
    ..Clinical guidelines for pharmacologic analgesia and sedation in newborns based on robust scientific data are lacking, as are measures of clinical efficacy...
  82. ncbi Overview of the therapeutic management of insomnia with zolpidem
    Yue Joe Lee
    Department of Psychiatry, National Taiwan University, Taiwan
    CNS Drugs 18:17-23; discussion 41, 43-5. 2004
    ....
  83. ncbi Electroencephalogram monitoring facilitates sedation with propofol for routine ERCP: a randomized, controlled trial
    Till Wehrmann
    Department of Internal Medicine I, Academic Hospital Hanover Siloah, Germany
    Gastrointest Endosc 56:817-24. 2002
    ..Because level of consciousness is difficult to judge by clinical observation alone, electroencephalogram monitoring has been used to guide general anesthesia...
  84. ncbi Gastroenterologist-administered propofol versus meperidine and midazolam for advanced upper endoscopy: a prospective, randomized trial
    John J Vargo
    Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Gastroenterology 123:8-16. 2002
    ..Additionally, its cost-effectiveness has not been studied...
  85. ncbi Cognitive behavior therapy and pharmacotherapy for insomnia: a randomized controlled trial and direct comparison
    Gregg D Jacobs
    Sleep Disorders Center, Beth Israel Deaconess Medical Center, Laboratory of Neurophysiology, Harvard Medical School, Boston, MA 02215, USA
    Arch Intern Med 164:1888-96. 2004
    ..The objective of this study was to evaluate the clinical efficacy of behavioral and pharmacological therapy, singly and in combination, for chronic sleep-onset insomnia...
  86. ncbi Reciprocal congenics defining individual quantitative trait Loci for sedative/hypnotic sensitivity to ethanol
    B Bennett
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Alcohol Clin Exp Res 26:149-57. 2002
    ..The derivation of these strains is reviewed here...
  87. ncbi Pentobarbital enhances GABAergic neurotransmission to cardiac parasympathetic neurons, which is prevented by expression of GABA(A) epsilon subunit
    Mustapha Irnaten
    Department of Pharmacology, George Washington University, Washington, DC 20037, USA
    Anesthesiology 97:717-24. 2002
    ..The authors tested whether pentobarbital augments the inhibitory GABAergic neurotransmission to cardiac parasympathetic neurons, and whether expression of the GABA(A) epsilon subunit prevents this facilitation...
  88. ncbi GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic
    Povl Krogsgaard-Larsen
    Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
    Biochem Pharmacol 68:1573-80. 2004
    ..In this connection, a series of GABA(A) ligands has been developed showing pharmacological profiles ranging from low-efficacy partial GABA(A) agonist activity to selective antagonist effect...
  89. pmc Accounting for the sedative and analgesic effects of medication changes during patient participation in clinical research studies: measurement development and application to a sample of institutionalized geriatric patients
    Philip Sloane
    Cecil G Sheps Center for Health Services Research, Department of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
    Contemp Clin Trials 29:140-8. 2008
    ..This paper describes the development, and illustrates the use, of a method we developed to address this issue, in which we generate single continuous variables to represent the daily sedative and analgesic loads of multiple medications...
  90. ncbi Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: the DORM study
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, New South Wales, Australia
    Ann Emerg Med 56:392-401.e1. 2010
    ..We determine whether droperidol, midazolam, or the combination is more effective for intramuscular sedation in violent and acute behavioral disturbance in the emergency department (ED)...
  91. ncbi Dexmedetomidine pharmacodynamics: part I: crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers
    Yung Wei Hsu
    Human Pharmacology Laboratory, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 101:1066-76. 2004
    ..Dexmedetomidine, a highly selective alpha2-adrenoceptor agonist used for short-term sedation of mechanically ventilated patients, has minimal effect on ventilation...
  92. pmc Variations in anxiolytic and hypnotic prescribing by GPs: a cross-sectional analysis using data from the UK Quality and Outcomes Framework
    Zoi Tsimtsiou
    Department of General Practice and Primary Care, King s College London School of Medicine at Guy s, King s College and St Thomas Hospitals, London
    Br J Gen Pract 59:e191-8. 2009
    ..Wide variations in anxiolytic and hypnotic prescribing by GPs in England have been described, but are largely unexplained...
  93. ncbi Current practices in sedation and analgesia for mechanically ventilated critically ill patients: a prospective multicenter patient-based study
    Jean Francois Payen
    Department of Anesthesiology and Critical Care, Albert Michallon Hospital, Grenoble, France
    Anesthesiology 106:687-95; quiz 891-2. 2007
    ....
  94. ncbi Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data
    G Hajak
    Department of Psychiatry and Psychotherapy, University of Regensburg, Germany
    Addiction 98:1371-8. 2003
    ..To substantiate and re-evaluate this situation, the world literature was reviewed for cases of dependence of both agents; these cases were analysed in order to identify certain underlying patterns, if evident...
  95. ncbi The expert consensus guideline series. Treatment of behavioral emergencies 2005
    Michael H Allen
    University of Colorado School of Medicine, USA
    J Psychiatr Pract 11:5-108; quiz 110-2. 2005
    ..We undertook a new survey of expert opinion to update recommendations from the earlier survey...
  96. ncbi Randomized, controlled, cross-over clinical trial comparing intravenous midazolam sedation with nitrous oxide sedation in children undergoing dental extractions
    K E Wilson
    Department of Sedation, Newcastle Dental School and Hospital, Framlington Place, Newcastle upon Tyne NE2 4BW, UK
    Br J Anaesth 91:850-6. 2003
    ..A study was therefore designed to investigate the use of midazolam, for i.v. sedation in paediatric dental patients...
  97. ncbi ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimens
    Daniel L Herr
    Washington Hospital Center, Washington, DC 2010, USA
    J Cardiothorac Vasc Anesth 17:576-84. 2003
    ..To compare dexmedetomidine-based to propofol-based sedation after coronary artery bypass graft (CABG) surgery in the intensive care unit (ICU)...
  98. ncbi Sedation with propofol for routine ERCP in high-risk octogenarians: a randomized, controlled study
    Andrea Riphaus
    Department of Internal Medicine I Gastroenterology and Interventional Endoscopy, Klinikum Hannover Siloah, Teaching Hospital of the Hannover Medical School, Hannover, Germany
    Am J Gastroenterol 100:1957-63. 2005
    ....
  99. ncbi Insomnia risks and costs: health, safety, and quality of life
    Mark R Rosekind
    Alertness Solutions, Cupertino, CA 95014, USA
    Am J Manag Care 16:617-26. 2010
    ....
  100. ncbi Use of dexmedetomidine in the pediatric intensive care unit
    Marcia L Buck
    Department of Pharmacy Services, University of Virginia Children s Hospital, Charlottesville, Virginia 22908, USA
    Pharmacotherapy 28:51-7. 2008
    ..To determine the safety, effectiveness, and dosing of dexmedetomidine in intensive care infants and children who require sedation, and the rationale for patient selection...
  101. pmc Drug burden index score and functional decline in older people
    Sarah N Hilmer
    Intramural Research Program, National Institute on Aging, Baltimore and Bethesda, MD, USA
    Am J Med 122:1142-1149.e1-2. 2009
    ..Here we evaluate the association between DBI and functional outcomes in Health, Aging and Body Composition study participants over 5 years...

Research Grants63

  1. Genetic Vulnerability to Alcohol Withdrawal and Genetically Correlated Behaviors
    Kari J Buck; Fiscal Year: 2012
    ....
  2. Structural Rearrangements in GABA-A Receptors
    CYNTHIA M CZAJKOWSKI; Fiscal Year: 2012
    ....
  3. Neurosteroid-BZ combinations: Strategy for reducing abuse and sedation
    James K Rowlett; Fiscal Year: 2013
    ..The ultimate goal for this research program is to provide critical preclinical information for development of a broadly effective combination product with an improved side effect profile for treating anxiety disorders. ..
  4. 1/3-Reducing Suicial Ideation Through Insomnia Treatment (REST-IT)
    WILLIAM VAUGHN MCCALL; Fiscal Year: 2013
    ..The results of this study will inform the appropriate management of patients with mild-moderate suicidal ideation, insomnia and depression - representing an extremely common clinical scenario. ..
  5. Structure of the GABA-A Receptor Binding Sites
    CYNTHIA M CZAJKOWSKI; Fiscal Year: 2013
    ....
  6. Structure of the GABA-A Receptor Binding Sites
    CYNTHIA M CZAJKOWSKI; Fiscal Year: 2012
    ..abstract_text> ..
  7. Cognitive Behavioral Therapy for Insomnia and Nocturnal Hot Flashes in Menopause
    Sara Nowakowski; Fiscal Year: 2012
    ..We propose to test the effectiveness of a primary care based, nurse-delivered, non-pharmacological intervention to improve menopause-associated insomnia, thereby improving quality of life and reducing costs to society. ..
  8. Frontal Cerebral Hypothermia as a Treatment for Insomnia
    Eric A Nofzinger; Fiscal Year: 2012
    ..The availability of a safe, effective home-based medical device for the treatment of insomnia such as that proposed in this Phase II SBIR application would be expected to have a significant public health impact. ..
  9. Behavioral Insomnia Therapy for those with Insomnia and Depression
    Colleen E Carney; Fiscal Year: 2012
    ..The resultant public health benefits from the proposed study include improved sleep, mood, well-being, and corollary medical and psychiatric conditions for depressed patients with insomnia. ..
  10. Rehabilitation of Stress-Induced Insomnia
    Pingfu Feng; Fiscal Year: 2009
    ....
  11. Conference-College on Problems of Drug Dependence
    Martin Adler; Fiscal Year: 2009
    ..Submitted abstracts are reviewed and divided into poster and oral sessions to insure a balance with the chosen symposia representative of the various research facets of the drug abuse and addiction field. ..
  12. fMRI Studies Investigating the Choice Effects of Sedative/Hypnotics
    Stephanie C Licata; Fiscal Year: 2010
    ..These studies will contribute to the overarching goals of the field, which has been focused on determining how BZs mediate their behavioral effects in an effort to separate the clinically useful effects from their abuse potential. ..
  13. Annual Meeting of College on Problems of Drug Dependence
    Martin W Adler; Fiscal Year: 2013
    ..Plenary and award lectures as well as several satellite meetings and specialty workshops will complete the program. ..
  14. Psychoactive Medications: Associations with Delirium Persistance vs Resolution
    Edward Marcantonio; Fiscal Year: 2009
    ..resolution of delirium. Our results will inform the medication management of delirium and the design of specific evidence-based interventions to treat delirium and improve functional recovery in both acute and post-acute care settings. ..
  15. Behavioral Pharmacology and GHB Physical Dependence
    Elise M Weerts; Fiscal Year: 2010
    ..Physical dependence in the context of self-injection of GHB, GBL and 1,4-BD will also be evaluated. These studies will provide critical information on the behavioral pharmacology and dependence-producing effects of GHB. ..
  16. STIMULANTS, DEPRESSANTS & HALLUCINOGENS AS REINFORCERS
    Gail Winger; Fiscal Year: 2003
    ..These drugs can be those that the WHO or the FDA is considering for scheduling decisions, drugs made by industrial or academic medicinal chemists, or industrial drugs that are being considered for clinical testing. ..
  17. BETA-CARBOLINES: VALIUM AGONISTS AND ANTAGONISTS
    James Cook; Fiscal Year: 1992
    ....
  18. ABUSE LIABILITY OF COMMONLY PRESCRIBED HYPNOTICS
    CRAIG RUSH; Fiscal Year: 1999
    ..Thus, this FIRST Award will sere as a foundation for future R01 applications to study sedative hypnotic compounds with unique neuropharmacological profiles. ..
  19. PHARMACOLOGY OF ANESTHETICS IN HEMORRHAGIC SHOCK
    Ken Johnson; Fiscal Year: 2002
    ..abstract_text> ..
  20. RATIONAL PHARMACOTHERAPY OF PRIMARY INSOMNIA
    Daniel Buysse; Fiscal Year: 2004
    ..The Principal Investigator will mentor trainees in analyses of existing data, design and implementation of the clinical trial, described above, and new studies designed by the trainees themselves. ..
  21. Urban-Rural Sedative & Anxiolytic Use in Long Term Care
    Sally Rigler; Fiscal Year: 2005
    ....
  22. DETERMINANTS OF THE BEHAVIORAL EFFECTS OF ABUSED DRUGS
    James Barrett; Fiscal Year: 1991
    ..These experiments should provide valuable information at the integrative level of behavior on the behavioral and pharmacological mechanisms underlying the activity of a major class of abused drugs...
  23. GENETIC SELECTION FOR BENZODIAZEPINE SENSITIVITY
    EDWARD GALLAHER; Fiscal Year: 1990
    ..And finally, studies on the co- segregation of other BZ actions in the two lines will provide evidence about the commonality of underlying mechanisms...
  24. SLEEP IN OLDER WOMEN--EFFECTS OF ESTROGEN
    KAREN MOE; Fiscal Year: 2001
    ..This study is the first step in a research program investigating the relationship between sex steroids and sleep in older individuals. ..
  25. Feasibility of Frontal Cerebral Hypothermia as a Treatment for Insomnia
    Eric Nofzinger; Fiscal Year: 2009
    ..The availability of a safe, effective medical device for the treatment of insomnia such as that proposed in this Phase I STTR application would be expected to have a significant public health impact. ..
  26. Neurochemical Substrates of Sedative/Hypnotic Action:Proton MRS Studies
    STEPHANIE LICATA; Fiscal Year: 2009
    ....
  27. CANNABINOID ABUSE EFFECTS ON LEARNING AND MEMORY
    JOSEPH MOERSCHBAECHER; Fiscal Year: 2003
    ..In addition, studies involving the actions of the cannabinoid receptor antagonist alone will provide valuable data concerning the potential use of this and related agents in the pharmacotherapy of cannabinoid abuse. ..
  28. BENZODIAZEPINE EFFECTS ON THE PERCEPTION OF SLEEP
    Wallace Mendelson; Fiscal Year: 1993
    ....
  29. AEROBIC FITNESS: SLEEP AND ITS CORRELATES IN THE AGED
    Michael Vitiello; Fiscal Year: 1992
    ....
  30. MECHANISM OF SEDATIVE HYPNOTIC TOLERANCE AND DEPENDENCE
    Andrea Allan; Fiscal Year: 1991
    ..It is anticipated that these studies will provide insight into the neural mechanisms responsible for benzodiazepine and barbiturate abuse...
  31. Next-day Behavioral Effects of Trazodone
    Anthony Liguori; Fiscal Year: 2009
    ..Ultimately, the results may alter the perception and prescription of this generally well-accepted compound. ..
  32. Structure of the GABA-A receptor ligand-binding pocket
    David Wagner; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  33. Functional Analysis of GABAerglc Sedative/Anxiolytics
    NANCY ATOR; Fiscal Year: 2007
    ..abstract_text> ..
  34. AGE RELATED SLEEP IMPAIRMENT--POSSIBLE INTERVENTIONS
    Michael Vitiello; Fiscal Year: 2003
    ..Further, such interventions may have significant impact in decreasing morbidity and mortality directly related to such sleep disturbance or its inappropriate treatment with chronic hypnotic medications. ..
  35. MINIMIZING WORK SCHEDULE DISRUPTION WITH BRIGHT LIGHT
    Scott Campbell; Fiscal Year: 1993
    ..It is expected that these important and necessary laboratory-based, simulated night shift studies will form the basis for subsequent investigations to evaluate the efficacy of such interventions in applied settings...
  36. NOVEL ANESTHETIC DRUG DELIVERY SYSTEM
    DIANE GARGANO; Fiscal Year: 2000
    ..PROPOSED COMMERCIAL APPLICATIONS: The commercial application is the development of a new drug delivery device to increase the safety of intravenous anesthesia for all patients, and in particular elderly patients. ..
  37. GENDER AND ABUSABLE PRESCRIPTION DRUGS
    Linda Simoni Wastila; Fiscal Year: 1999
    ....
  38. RAT MODELS TO SCREEN COMPOUNDS INDUCING SLOW-WAVE SLEEP
    Bernard Bergmann; Fiscal Year: 2003
    ..These new compounds will represent a major breakthrough in the treatment of conditions and illnesses which involve disturbed sleep. ..
  39. CAFFEINE-INDUCED SUPERSENSITIVITY TO ADENOSINE AGONISTS
    M Newland; Fiscal Year: 1991
    ..The provisional hypothesis is that chronic exposure to caffeine induces supersensitivity that is specific to adenosine agonists and tolerance that is specific to methylxanthines...
  40. Polysomnographic Assessment of Alternative Treatment
    Donald Bliwise; Fiscal Year: 2006
    ..abstract_text> ..
  41. BEHAVIORAL INSOMNIA THERAPY FOR FIBROMYALGIA PATIENTS
    Jack Edinger; Fiscal Year: 2001
    ..Results should also improve understanding of the FM syndrome in general and provide new information about the potential role of behavioral therapy in the overall management of this disorder. ..
  42. Epidemiology of Disturbed Sleep Among Adolescents
    Robert Roberts; Fiscal Year: 2006
    ..Data will be collected using laptop computers and audio-computer assisted self-interview (ACASI) technology. ..
  43. Zolpidem and Cognitive Behavioral Therapy for Insomnia in Older Adults
    Katie Stone; Fiscal Year: 2009
    ..Results from this trial are essential to inform treatment recommendations for older adults with insomnia. ..
  44. Combined Behavioral/Pharmacological Therapy for Insomnia
    William Wohlgemuth; Fiscal Year: 2005
    ..Our preliminary data have provided initial support for our expectations and the proposed study is designed to confirm these hypotheses. ..
  45. NEUROCHEMICAL EFFECTS OF SEDATIVE HYPNOTICS
    Boris Tabakoff; Fiscal Year: 1980
    ..Neurotransmitter turnover, enzyme activities associated with neuronal activity, the interactions of agonists with their neuronal receptors will be assessed during chronic treatment with sedative hypnotics and during withdrawal...
  46. PENTOBARBITAL ACTIVATION IN SELECTED MOUSE LINES
    CARLTON ERICKSON; Fiscal Year: 1993
    ..The proposed studies will provide information on the mechanisms behind barbiturate's intoxicating effects in mice after low doses, and perhaps in man after abusable doses of pentobarbital...
  47. SITE AND RECEPTOR MECHANISM OF MK801 DELTA STIMULATION
    Irwin Feinberg; Fiscal Year: 2000
    ..It might also lead to the development of a novel class of hypnotics that stimulates a more physiological sleep EEG. ..
  48. RAT MODELS TO SCREEN COMPOUNDS INDUCING SLOW-WAVE SLEEP
    Bernard Bergmann; Fiscal Year: 2000
    ..To test the biobehavioral screen and the EEG model using published analogs with known binding and sedative properties. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  49. AN EXPERT SYSTEM ADVISOR FOR DRUG DETOXIFICATION
    ROBERT HINK; Fiscal Year: 1992
    ..The expert system will be validated by comparing the computer-generated withdrawal orders to orders written by nationally recognized physician experts...
  50. Insomnia Intervention for Breast Cancer Survivors
    Dana Epstein; Fiscal Year: 2003
    ..This feasibility pilot study will provide the basis for a larger study to evaluate efficacy and to examine the effect of the intervention on the quality of survival time and comorbidities among BCS. ..
  51. Exercise to Relieve Cancer-Related Insomnia and Fatigue
    Elizabeth Coleman; Fiscal Year: 2007
    ..As their physical activity and functional status improve, patients can continue to manage their activities of daily living and may be more likely to continue cancer treatment, thus increasing their survival chances. ..
  52. DAYTIME SLEEPINESS--PREVALENCE, CONSEQUENCES, AND RISKS
    Thomas Roth; Fiscal Year: 2003
    ..The important contribution of the present proposal is that it will be the first population-based study to use laboratory assessments, its consequences and risks to measure sleepiness. ..
  53. Role of Calcium in Cocaine-Induced Sensitization
    STEPHANIE LICATA; Fiscal Year: 2002
    ..Second, rats will receive either acute or repeated cocaine and relative abundance of either calmodulin or CaMKII will be measured in the VTA and substantia nigra using immunolabeling techniques. ..
  54. Epidemiology of Prescription Drug Abuse in the United States
    SEAN MCCABE; Fiscal Year: 2007
    ..It will help identify risk factors for substance abuse. Most importantly, the findings will provide guidance for the prevention, assessment, and treatment of prescription drug abuse. [unreadable] [unreadable]..
  55. Nonmedical Prescription Drug Use among College Students
    SEAN MCCABE; Fiscal Year: 2005
    ..Findings from this research will have important implications for the understanding of the epidemiology, prevention and treatment of prescription drug abuse. ..
  56. Abuse of benzodiazepine/heroin combinations
    STEPHANIE LICATA; Fiscal Year: 2006
    ..Together, these studies will determine how hard the animal is willing to work for this drug combination, and to what extent do the alpha 1 and alpha 2 subunits of the GABAA receptor contribute to this behavior? ..
  57. Sexual Orientation, Substance Use and Mental Health
    SEAN MCCABE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  58. Protective Influence of Residential Learning Communities
    SEAN MCCABE; Fiscal Year: 2006
    ..At each measurement point, participants will complete a set of measures that assess substance use behaviors and constructs addressed by RLCs. ..
  59. Prescription Drug Abuse Among College Students
    SEAN MCCABE; Fiscal Year: 2005
    ....
  60. CHRONIC BENZODIAZEPINES: BEHAVIOR AND NEUROCHEMISTRY
    David Greenblatt; Fiscal Year: 2005
    ....
  61. Metabolic Consequences of HAART: CYP3A and P-gp
    David Greenblatt; Fiscal Year: 2003
    ..This multidisciplinary proposal provides a clinical and scientific basis to assess the effects of currently available as well as experimental HAART medications on human CYP3A and P-gp. ..