hallucinogens

Summary

Summary: Drugs capable of inducing illusions, hallucinations, delusions, paranoid ideations, and other alterations of mood and thinking. Despite the name, the feature that distinguishes these agents from other classes of drugs is their capacity to induce states of altered perception, thought, and feeling that are not experienced otherwise.

Top Publications

  1. ncbi Hallucinogens
    David E Nichols
    Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907 2091, USA
    Pharmacol Ther 101:131-81. 2004
  2. ncbi Phenomenon of new drugs on the Internet: the case of ketamine derivative methoxetamine
    Ornella Corazza
    School of Pharmacy, University of Hertfordshire, Hatfield, UK
    Hum Psychopharmacol 27:145-9. 2012
  3. pmc Dance clubbing on MDMA and during abstinence from Ecstasy/MDMA: prospective neuroendocrine and psychobiological changes
    A C Parrott
    Department of Psychology Swansea University, Swansea, UK
    Neuropsychobiology 57:165-80. 2008
  4. ncbi Acute administration of 3,4-methylenedioxymethamphetamine induces profound hyperthermia, blood-brain barrier disruption, brain edema formation, and cell injury
    Hari Shanker Sharma
    Laboratory of Neurochemistry, Division of Neurotoxicology, National Center of Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA
    Ann N Y Acad Sci 1139:242-58. 2008
  5. ncbi Acute effects of nocturnal doses of MDMA on measures of impulsivity and psychomotor performance throughout the night
    K P C Kuypers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 192:111-9. 2007
  6. ncbi Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies
    Erich Studerus
    University Hospital of Psychiatry Zurich, Neuropsychopharmacology and Brain Imaging and Heffter Research Center, Zurich, Switzerland
    J Psychopharmacol 25:1434-52. 2011
  7. pmc Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects
    Roland R Griffiths
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Psychopharmacology (Berl) 218:649-65. 2011
  8. ncbi Heaven and hell--a phenomenological study of recreational use of 4-HO-MET in Sweden
    Anette Kjellgren
    Department of Psychology, Karlstad University, Karlstad, Sweden
    J Psychoactive Drugs 43:211-9. 2011
  9. pmc Cortisol and 3,4-methylenedioxymethamphetamine: neurohormonal aspects of bioenergetic stress in ecstasy users
    A C Parrott
    Department of Psychology, Swansea University, Swansea SA2 8PP, UK
    Neuropsychobiology 60:148-58. 2009
  10. ncbi Determination of MDMA and its metabolites in blood and urine by gas chromatography-mass spectrometry and analysis of enantiomers by capillary electrophoresis
    Nieves Pizarro
    Pharmacology Research Unit, Institut Municipal d Investigacio Medica IMIM, Barcelona, Spain
    J Anal Toxicol 26:157-65. 2002

Detail Information

Publications330 found, 100 shown here

  1. ncbi Hallucinogens
    David E Nichols
    Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907 2091, USA
    Pharmacol Ther 101:131-81. 2004
    b>Hallucinogens (psychedelics) are psychoactive substances that powerfully alter perception, mood, and a host of cognitive processes. They are considered physiologically safe and do not produce dependence or addiction...
  2. ncbi Phenomenon of new drugs on the Internet: the case of ketamine derivative methoxetamine
    Ornella Corazza
    School of Pharmacy, University of Hertfordshire, Hatfield, UK
    Hum Psychopharmacol 27:145-9. 2012
    ..Better international collaboration levels and novel forms of intervention are necessary to tackle this fast-growing phenomenon...
  3. pmc Dance clubbing on MDMA and during abstinence from Ecstasy/MDMA: prospective neuroendocrine and psychobiological changes
    A C Parrott
    Department of Psychology Swansea University, Swansea, UK
    Neuropsychobiology 57:165-80. 2008
    ..The present study is the first to prospectively compare a group of recreational Ecstasy users when dance clubbing on 3,4-methylenedioxymethamphetamine (MDMA) and when clubbing during abstinence from Ecstasy/MDMA...
  4. ncbi Acute administration of 3,4-methylenedioxymethamphetamine induces profound hyperthermia, blood-brain barrier disruption, brain edema formation, and cell injury
    Hari Shanker Sharma
    Laboratory of Neurochemistry, Division of Neurotoxicology, National Center of Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA
    Ann N Y Acad Sci 1139:242-58. 2008
    ....
  5. ncbi Acute effects of nocturnal doses of MDMA on measures of impulsivity and psychomotor performance throughout the night
    K P C Kuypers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 192:111-9. 2007
    ..These studies assessed performance during daytime, whereas in real life, dance-attendees leaving a party use the drug during the night...
  6. ncbi Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies
    Erich Studerus
    University Hospital of Psychiatry Zurich, Neuropsychopharmacology and Brain Imaging and Heffter Research Center, Zurich, Switzerland
    J Psychopharmacol 25:1434-52. 2011
    ....
  7. pmc Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects
    Roland R Griffiths
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Psychopharmacology (Berl) 218:649-65. 2011
    ..This dose-effect study extends previous observations showing that psilocybin can occasion mystical-type experiences having persisting positive effects on attitudes, mood, and behavior...
  8. ncbi Heaven and hell--a phenomenological study of recreational use of 4-HO-MET in Sweden
    Anette Kjellgren
    Department of Psychology, Karlstad University, Karlstad, Sweden
    J Psychoactive Drugs 43:211-9. 2011
    ..The experiences described show great similarity with classic psychedelic substances as LSD or psilocybin. More research is needed about health hazards or possible therapeutic potentials...
  9. pmc Cortisol and 3,4-methylenedioxymethamphetamine: neurohormonal aspects of bioenergetic stress in ecstasy users
    A C Parrott
    Department of Psychology, Swansea University, Swansea SA2 8PP, UK
    Neuropsychobiology 60:148-58. 2009
    ..3,4-Methylenedioxymethamphetamine (MDMA) can affect both neurotransmitter and neurohormonal activity. This review will debate the role of the metabolic activation hormone cortisol for the psychobiological effects of ecstasy/MDMA...
  10. ncbi Determination of MDMA and its metabolites in blood and urine by gas chromatography-mass spectrometry and analysis of enantiomers by capillary electrophoresis
    Nieves Pizarro
    Pharmacology Research Unit, Institut Municipal d Investigacio Medica IMIM, Barcelona, Spain
    J Anal Toxicol 26:157-65. 2002
    ..Stereoselective disposition of MDMA and MDA was confirmed. HMMA disposition seems to be in apparent contradiction with MDMA findings as the enantiomer ratio is close to 1 and constant over the time...
  11. ncbi Acute dose of MDMA (75 mg) impairs spatial memory for location but leaves contextual processing of visuospatial information unaffected
    Kim P C Kuypers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 189:557-63. 2007
    ..Two factors may have confounded results in abstinent users: memory task characteristics and polydrug use...
  12. ncbi Obsessive-compulsive disorder followed by psychotic episode in long-term ecstasy misuse
    Carlo Marchesi
    Department of Neuroscience, Psychiatric Division, University of Parma, Italy
    World J Biol Psychiatry 10:599-602. 2009
    ..After several months of discontinuation of the drug, major depression with psychotic features developed in one subject and a psychotic disorder in the other individual. No mental disorder preceded the use of ecstasy in any subject...
  13. ncbi Evidence that MDMA ('ecstasy') increases cannabinoid CB2 receptor expression in microglial cells: role in the neuroinflammatory response in rat brain
    Elisa Torres
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    J Neurochem 113:67-78. 2010
    ..In conclusion, CB2 receptor activation reduces the neuroinflammatory response following MDMA and provides partial neuroprotection against the drug...
  14. ncbi Substance use and related problems: a study on the abuse of recreational and not recreational drugs in Northern Italy
    Raimondo Maria Pavarin
    Osservatorio Epidemiologico Metropolitano Dipendenze Patologiche, AUSL Bologna, Via San Lorenzo 1, 40100 Bologna, Italy
    Ann Ist Super Sanita 42:477-84. 2006
    ....
  15. ncbi Modelling of the concentration--effect relationship of THC on central nervous system parameters and heart rate -- insight into its mechanisms of action and a tool for clinical research and development of cannabinoids
    A Strougo
    Centre for Human Drug Research, Statistics, Leiden, The Netherlands
    J Psychopharmacol 22:717-26. 2008
    ..Third, many new cannabinoid agonists and antagonists are in development. PK-PD models for THC can be used as a reference for new agonists or as tools to quantitate the pharmacological properties of cannabinoid antagonists...
  16. ncbi 3,4-Methylenedioxymethamphetamine increases pro-interleukin-1beta production and caspase-1 protease activity in frontal cortex, but not in hypothalamus, of Dark Agouti rats: role of interleukin-1beta in neurotoxicity
    E O'SHEA
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense, Madrid 28040, Spain
    Neuroscience 135:1095-105. 2005
    ....
  17. ncbi Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration
    G J H Dumont
    Unit for Clinical Psychopharmacology and Neuropsychiatry, Department of Psychiatry, Radboud University Nijmegen Medical Centre, 966, PO Box 9101, Nijmegen NL 6500 HB, The Netherlands
    Soc Neurosci 4:359-66. 2009
    ..MDMA induces oxytocin release in humans, which may be involved in the characteristic prosocial effects of ecstasy...
  18. ncbi Effect of intrapulmonary tetrahydrocannabinol administration in humans
    L Zuurman
    Centre for Human Drug Research, Pharmacology CNS, Leiden, The Netherlands
    J Psychopharmacol 22:707-16. 2008
    ..These results may be applicable in the development of novel cannabinoid agonists and antagonists, and in studies of the pharmacology and physiology of cannabinoid systems in humans...
  19. pmc 5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice
    Adam L Halberstadt
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0804, USA
    Neuropsychopharmacology 34:1958-67. 2009
    Although it is well established that hallucinogens act as 5-HT(2A) and 5-HT(2C) receptor agonists, little is known about the relative contributions of 5-HT(2A) and 5-HT(2C) receptors to the acute behavioral effects of these drugs...
  20. pmc 5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites
    R L Jakab
    Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 95:735-40. 1998
    ..To identify the cortical sites where 5-hydroxytryptamine2A (5-HT2A) serotonin receptors respond to the action of hallucinogens and atypical antipsychotic drugs, we have examined the cellular and subcellular distribution of these ..
  21. ncbi Sub-chronic psychotomimetic phencyclidine induces deficits in reversal learning and alterations in parvalbumin-immunoreactive expression in the rat
    Z Abdul-Monim
    Bradford School of Pharmacy, University of Bradford, Bradford, UK
    J Psychopharmacol 21:198-205. 2007
    ....
  22. ncbi The hallucinogen 1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane (DOI) increases cortical extracellular glutamate levels in rats
    Jennifer L Scruggs
    Neuroscience Program and Departments of Psychiatry and Pharmacology, Vanderbilt University Medical Center, Nashville, TN, 37212, USA
    Neurosci Lett 346:137-40. 2003
    ..These data are consistent with the hypothesis that 5-HT(2A) receptor-mediated regulation of glutamate release is the mechanism through which hallucinogens activate the cerebral cortex.
  23. ncbi A review of acute effects of 3,4-methylenedioxymethamphetamine in healthy volunteers
    G J H Dumont
    Unit for Clinical Psychopharmacology and Neuropsychiatry, Department of Psychiatry, Radboud University Medical Centre Nijmegen, The Netherlands
    J Psychopharmacol 20:176-87. 2006
    ....
  24. pmc Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness
    Katherine A MacLean
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Psychopharmacol 25:1453-61. 2011
    ..The findings suggest a specific role for psilocybin and mystical-type experiences in adult personality change...
  25. ncbi Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: cellular and molecular mechanisms
    Johnalyn Lyles
    Molecular Neuropsychiatry Branch, National Institutes of Health National Institute on Drug Abuse Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res Brain Res Rev 42:155-68. 2003
    ..Much remains to be done in order to clarify the molecular and biochemical pathways involved in the long-term neuroplastic changes associated with MDMA abuse...
  26. ncbi Co-administration of THC and MDMA ('ecstasy') synergistically disrupts memory in rats
    June M Young
    School of Psychology, University of New England, Armidale, NSW, Australia
    Neuropsychopharmacology 30:1475-82. 2005
    ....
  27. ncbi Behavioral and neurochemical consequences of multiple MDMA administrations in the rat: role of individual differences in anxiety-related behavior
    V Ludwig
    Experimental and Physiological Psychology, Philipps University of Marburg, Gutenbergstr 18, 35037 Marburg, Germany
    Behav Brain Res 189:52-64. 2008
    ..Detecting such sequels partly requires consideration of individual differences...
  28. ncbi Associations between psychedelic use, abuse, and dependence and lifetime panic attack history in a representative sample
    Marcel O Bonn-Miller
    The University of Vermont, Burlington, VT, USA
    J Anxiety Disord 21:730-41. 2007
    ..The results are discussed in terms of better understanding the role of psychedelic use in relation to the occurrence of panic attacks...
  29. ncbi The nature of ecstasy-group related deficits in associative learning
    Catharine Montgomery
    School of Psychology, Liverpool John Moores University, 15 21 Webster Street, Liverpool L3 2ET, UK
    Psychopharmacology (Berl) 180:141-9. 2005
    ..RATIONALE/OBJECTIVES: Research has revealed associative learning deficits among users of ecstasy; the present study explored the component processes underlying these deficits...
  30. ncbi Relation of sex and estrous phase to deficits in prepulse inhibition of the startle response induced by ecstasy (MDMA)
    V Bubenikova
    Prague Psychiatric Center, Prague, Czech Republic
    Behav Pharmacol 16:127-30. 2005
    ..Our result showed that female rats in the proestrous and estrous phases were less sensitive to the disruption of PPI by MDMA...
  31. ncbi Hallucinogen persisting perception disorder: what do we know after 50 years?
    John H Halpern
    Harvard Medical School, Biological Psychiatry Laboratory, Alcohol and Drug Abuse Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478 9106, USA
    Drug Alcohol Depend 69:109-19. 2003
    ..use, but less commonly with LSD administered in research or treatment settings, or with use of other types of hallucinogens. There are case reports, but no randomized controlled trials, of successful treatment with neuroleptics, ..
  32. pmc A developmental comparison of the neurobehavioral effects of ecstasy (MDMA)
    Brian J Piper
    Neuroscience and Behavior Program, University of Massachusetts, Amherst, MA 01003 7710, USA
    Neurotoxicol Teratol 29:288-300. 2007
    ..Several physiological, behavioral, and neurochemical MDMA issues requiring further study are also outlined...
  33. ncbi Mescaline use for 5700 years
    Jan G Bruhn
    Lancet 359:1866. 2002
  34. ncbi Are there sex differences associated with the effects of ecstasy/3,4-methylenedioxymethamphetamine (MDMA)?
    Kelly Allott
    Department of Psychology, Monash University, VIC 3800, Australia
    Neurosci Biobehav Rev 31:327-47. 2007
    ..These findings are consistent with research outcomes reported for other substances such as amphetamines and cocaine. Potential reasons for these sex differences and directions for future research are discussed...
  35. ncbi Altered states: the clinical effects of Ecstasy
    J C Cole
    Psychology Department, Liverpool University, Liverpool L69 7ZA, UK
    Pharmacol Ther 98:35-58. 2003
    ..Demonstration of neurotoxicity in human users of Ecstasy is hampered by a number of confounds that the majority of published studies have failed to address. These confounds are reviewed and their impact is discussed...
  36. ncbi The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy")
    A Richard Green
    AstraZeneca R and D Charnwood, Loughborough, LE11 5RH, UK
    Pharmacol Rev 55:463-508. 2003
    ..However, such evidence is complicated by the lack of knowledge of doses ingested and the fact that many subjects studied are or have been poly-drug users...
  37. ncbi Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats
    Tomas Palenicek
    Prague Psychiatric Center, Ustavni 91, 181 03 Bohnice, Prague 8, Czech Republic
    Psychopharmacology (Berl) 225:75-93. 2013
    ..Behavioral, neurochemical and pharmaco-EEG profiles of a new synthetic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats were examined...
  38. pmc Evidence for significant polydrug use among ecstasy-using college students
    Eric D Wish
    Center for Substance Abuse Research, University of Maryland, College Park 20740, USA
    J Am Coll Health 55:99-104. 2006
    ..10%), LSD (38% vs. 5%), cocaine (46% vs 2%), and heroin (17% vs 1%) in the past year. Significant polydrug use among college student ecstasy users has important implications for their substance abuse treatment...
  39. ncbi Sex differences in the neurochemical and functional effects of MDMA in Sprague-Dawley rats
    Q David Walker
    Department of Pharmacology and Integrated Program in Toxicology, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacology (Berl) 189:435-45. 2007
    ..3,4-Methylenedioxymethamphetamine (MDMA; "Ecstasy") use has been associated with acute toxicities and persistent depletion of the neurotransmitter serotonin (5-HT)...
  40. ncbi Cannabis and Ecstasy/MDMA (3,4-methylenedioxymethamphetamine): an analysis of their neuropsychobiological interactions in recreational users
    A C Parrott
    Swansea University, Swansea, Wales, UK
    J Neural Transm 114:959-68. 2007
    ..In order to investigate these potential complexities, future research will need better empirical data on the exact patterns of co-drug usage...
  41. ncbi MDMA (3,4-Methylenedioxymethamphetamine) or ecstasy: the neuropsychobiological implications of taking it at dances and raves
    A C Parrott
    Department of Psychology, University of Wales, Swansea, UK
    Neuropsychobiology 50:329-35. 2004
    ..Consistent with this prediction, the extent of self-reported dancing/exercise when on MDMA has recently been shown to be associated with significantly more psychobiological problems afterwards...
  42. pmc Δ9-Tetrahydrocannabinol attenuates MDMA-induced hyperthermia in rhesus monkeys
    M A Taffe
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuroscience 201:125-33. 2012
    ..Relatively little scientific evidence on the thermoregulatory effects of THC in monkeys is available...
  43. ncbi Agonist-trafficking and hallucinogens
    Javier Gonzalez-Maeso
    Departments of Psychiatry, Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Med Chem 16:1017-27. 2009
    ..In this review, we summarize the current knowledge, as well as unresolved questions, regarding agonist-trafficking and the mechanism of action of hallucinogenic drugs...
  44. ncbi Cognitive performance in recreational users of MDMA of 'ecstasy': evidence for memory deficits
    A C Parrott
    Department of Psychology, University of East London, UK
    J Psychopharmacol 12:79-83. 1998
    ..Although the design of this study was far from ideal, these data are consistent with other findings of memory decrements in recreational MDMA users, possibly caused by serotonergic neurotoxicity...
  45. ncbi Psychological and cognitive effects of long-term peyote use among Native Americans
    John H Halpern
    Biological Psychiatry Laboratory, Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Biol Psychiatry 58:624-31. 2005
    b>Hallucinogens are widely used, both by drug abusers and by peoples of traditional cultures who ingest these substances for religious or healing purposes...
  46. ncbi Associations between use of cocaine, amphetamines, or psychedelics and psychotic symptoms in a community sample
    N Kuzenko
    Department of Psychiatry, University of Manitoba, Winnipeg, MB, Canada
    Acta Psychiatr Scand 123:466-74. 2011
    ..To investigate the association between use of cocaine, amphetamines, or psychedelics and psychotic symptoms...
  47. ncbi Harm potential of magic mushroom use: a review
    Jan van Amsterdam
    Laboratory for Health Protection Research, RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Regul Toxicol Pharmacol 59:423-9. 2011
    ..The low prevalent but unpredictable provocation of panic attacks and flash-backs remain, however, a point of concern...
  48. ncbi Long-term neuropsychiatric consequences of "ecstasy" (MDMA): a review
    Alonso G Montoya
    Department of Neurology, McLean Hospital, Belmont, MA 02478, USA
    Harv Rev Psychiatry 10:212-20. 2002
    ..Additional research is necessary to determine whether the MDMA-induced destruction of serotonergic neurons can have long-term and possibly permanent neuropsychiatric consequences in humans...
  49. ncbi Hug drug or thug drug? Ecstasy use and aggressive behavior
    Lesley Williams Reid
    Department of Sociology, Georgia State University, Atlanta, GA 30303, USA
    Violence Vict 22:104-19. 2007
    ..Those who exhibit low self-control are more affected by ecstasy use than those who do not in terms of aggression. Our findings add an important dimension to our current knowledge about the relationship between aggression and ecstasy...
  50. ncbi How strong is the evidence that brain serotonin neurons are damaged in human users of ecstasy?
    Stephen J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ontario, Canada
    Pharmacol Biochem Behav 71:845-55. 2002
    ..Until these issues are resolved, it cannot be assumed that ecstasy exposure represents a chronic serotonin deficiency condition...
  51. ncbi An investigation into the sub-acute effects of ecstasy on aggressive interpretative bias and aggressive mood - are there gender differences?
    Rosa Hoshi
    Clinical Psychopharmacology Unit, University College London, UK
    J Psychopharmacol 20:291-301. 2006
    ..Both male and female ecstasy users show a bias toward interpretation of ambiguous material in an aggressive manner when compared to controls 4 days after ecstasy use...
  52. ncbi Development, maintenance and temporal pattern of self-administration maintained by ecstasy (MDMA) in rats
    Susan Schenk
    School of Psychology, Victoria University of Wellington, PO Box 600, Wellington, New Zealand
    Psychopharmacology (Berl) 169:21-7. 2003
    ..3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") use is increasing around the globe but there is a paucity of studies examining the abuse liability of this drug...
  53. ncbi Acute psychological and physiological effects of MDMA ("Ecstasy") after haloperidol pretreatment in healthy humans
    M E Liechti
    University Hospital of Psychiatry Zurich, Research Unit, P O Box 68, CH 8029, Zurich, Switzerland
    Eur Neuropsychopharmacol 10:289-95. 2000
    ..Results are consistent with a partial dopaminergic mediation of the euphoriant effects of MDMA. In contrast, dopamine does not seem to contribute to the physiological effects of MDMA, indicating a role for serotonin and norepinephrine...
  54. ncbi Methylenedioxymethamphetamine (MDMA, 'ecstasy') serves as a robust positive reinforcer in a rat runway procedure
    Gudrun Wakonigg
    Department of Psychiatry, University of Innsbruck, Innsbruck, Austria
    Pharmacology 69:180-2. 2003
    ..These findings should reassure the drug abuse research community that the investigation of MDMA's reinforcing effect in the inexpensive and widely used rodent model is indeed feasible...
  55. ncbi Reinforcing effects of MDMA ("ecstasy") in drug-naive and cocaine-trained rats
    E Ratzenboeck
    Division of Neurochemistry, Department of Psychiatry, University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria
    Pharmacology 62:138-44. 2001
    ..When MDMA was tested after cocaine, there was no carryover of cocaine's reinforcing effect to that of MDMA, suggesting that MDMA and cocaine produce distinct interoceptive stimuli in rats...
  56. ncbi Acute psychological effects of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") are attenuated by the serotonin uptake inhibitor citalopram
    M E Liechti
    Psychiatric University Hospital Zürich Research Department, P O Box 68, CH 8029, Zurich, Switzerland
    Neuropsychopharmacology 22:513-21. 2000
    ..This finding suggests that the psychological effects of MDMA are mediated via action at the 5-HT uptake site to increase 5-HT release through the carrier, as expected from animal studies...
  57. ncbi Level of use of 3,4-methylenedioxymethamphetamine (MDMA or Ecstasy) in humans correlates with EEG power and coherence
    R I Dafters
    Psychology Department, Glasgow University, UK
    Psychopharmacology (Berl) 145:82-90. 1999
    ..Despite animal studies implicating 3,4-methylenedioxymethamphetamine (MDMA or Ecstasy) in serotonergic neurotoxicity, there is little direct evidence of changes in neural function in humans who use MDMA as a recreational drug...
  58. ncbi Ecstasy-induced psychotic disorder: six-month follow-up study
    M A Landabaso
    Drug Addiction Center, Barakaldo, Bizkaia, Spain
    Eur Addict Res 8:133-40. 2002
    ..To describe the psychiatric symptoms manifested by persons diagnosed for the first time as having ecstasy-induced psychotic disorder and to explore the evolution of their symptoms over a 6-month period...
  59. ncbi Neuropsychiatric consequences (atypical psychosis and complex-partial seizures) of ecstasy use: possible evidence for toxicity-vulnerability predictors and implications for preventative and clinical care
    Marco Vecellio
    Psychiatric University Hospital Zurich, Zurich, Switzerland
    J Psychopharmacol 17:342-5. 2003
    ..In vulnerable individuals, dose-independent ecstasy abuse can lead to unpredictable and potentially dangerous neuropsychiatric sequelae which require proper initial assessment and adequate treatment...
  60. pmc Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens
    Adam L Halberstadt
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States
    Neuropharmacology 61:364-81. 2011
    Serotonergic hallucinogens produce profound changes in perception, mood, and cognition...
  61. ncbi Enhanced intensity dependence and aggression history indicate previous regular ecstasy use in abstinent polydrug users
    Li Wan
    Department of Psychology and Neuroscience, Baylor University, Waco, TX 76798, USA
    Prog Neuropsychopharmacol Biol Psychiatry 33:1484-90. 2009
    ..3% of those who had been regular ecstasy users and 78.3% of those who had not. Overall, 76.3% of the participants were correctly classified...
  62. pmc The behavioral pharmacology of hallucinogens
    William E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30322, USA
    Biochem Pharmacol 75:17-33. 2008
    ..Animal models sensitive to the behavioral effects of the hallucinogens have been established and exploited...
  63. ncbi Reinforcing, subjective, and physiological effects of MDMA in humans: a comparison with d-amphetamine and mCPP
    Manuel Tancer
    Department of Psychiatry and Behavioral Neurosciences, Substance Abuse Research Division, Addiction Research Institute, Wayne State University, 2761 E Jefferson, Detroit, MI 48207, USA
    Drug Alcohol Depend 72:33-44. 2003
    ..In contrast, only the dopaminergic agents, d-amphetamine and MDMA, had reinforcing effects...
  64. ncbi Altered forebrain neurotransmitter responses to immobilization stress following 3,4-methylenedioxymethamphetamine
    L Matuszewich
    Department of Pharmacology, Boston University Medical School, Boston, MA 02118, USA
    Neuroscience 110:41-8. 2002
    ..This altered responsiveness may have implications for long-term functional consequences of MDMA abuse as well as the interactions between the serotonergic system and stress...
  65. ncbi QSAR of benzene derivatives: comparison of classical descriptors, quantum theoretic parameters and flip regression, exemplified by phenylalkylamine hallucinogens
    Brian W Clare
    Department of Chemistry, The University of Western Australia, 35 Stirling Highway, Crawley, W A 6009, Australia
    J Comput Aided Mol Des 16:611-33. 2002
    ....
  66. pmc Disrupted 'reflection' impulsivity in cannabis users but not current or former ecstasy users
    L Clark
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, School of Clinical Medicine, University of Cambridge, and Addenbrooke s Hospital, Cambridge, UK
    J Psychopharmacol 23:14-22. 2009
    ..However, the lack of effects in the two ecstasy groups suggests that the relationship between serotonin function, ecstasy use and impulsivity is more complex...
  67. ncbi Hallucinogens and dissociative agents naturally growing in the United States
    John H Halpern
    Biological Psychiatry Laboratory, Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478 9106, USA
    Pharmacol Ther 102:131-8. 2004
    ..Less well known is that many hallucinogens and dissociative agents can be obtained from plants and fungi growing wild or in gardens...
  68. ncbi Complex discriminative stimulus properties of (+)lysergic acid diethylamide (LSD) in C57Bl/6J mice
    Michael A Benneyworth
    Department of Pharmacology, Vanderbilt University School of Medicine, 8148 MRB III, Nashville, TN 37232, USA
    Psychopharmacology (Berl) 179:854-62. 2005
    ..The current paper is part of an ongoing effort to determine the utility of the drug discrimination technique for evaluating hallucinogenic drugs in mice...
  69. ncbi Adolescent salvia substance abuse
    Sundeep Singh
    University of Michigan Hospital, Department of Child and Adolescent Psychiatry, Ann Arbor, MI, USA
    Addiction 102:823-4. 2007
    ..These effects resolve within 30 minutes following use. Salvia has been banned in many countries, although it remains legal and easily assessable over the internet in the United States...
  70. ncbi Acute psychomotor effects of MDMA and ethanol (co-) administration over time in healthy volunteers
    G J H Dumont
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Psychopharmacol 24:155-64. 2010
    ..These findings may have implications for general neuropsychological functioning as this may provide a sense of adequate performance that does not agree with a significant reduction in psychomotor accuracy...
  71. ncbi A brief overview of the clinical pharmacology of "club drugs"
    Gena Covell Britt
    Division of Addiction Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23219, USA
    Subst Use Misuse 40:1189-201. 2005
    ..The neurobiology, clinical pharmacology, and treatment issues for each are discussed...
  72. ncbi Subjective effects of MDMA ('Ecstasy') on human sexual function
    Z Zemishlany
    Geha Psychiatric Hospital, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv University, P.O. Box 102, Petah Tikva 49 100, Israel
    Eur Psychiatry 16:127-30. 2001
    ..Orgasm was delayed but perceived as more intense. Erection was impaired in 40% of the men. It seems that MDMA impairs sexual performance, in spite of enhancement of sexual desire and the perception of greater satisfaction...
  73. ncbi Endogenous hallucinogens as ligands of the trace amine receptors: a possible role in sensory perception
    J V Wallach
    B S Cell and Molecular Biology, Peter Wallach Enterprises, 2758 Furlong Road, Doylestown, PA 18902, United States
    Med Hypotheses 72:91-4. 2009
    While the endogenous hallucinogens, N,N-dimethyltryptamine, 5-hydroxy-N,N-dimethyl-tryptamine and 5-methoxy-N,N-dimethyltryptamine, have been acknowledged as naturally occurring components of the mammalian body for decades, their ..
  74. ncbi MDMA ('ecstasy') and other 'club drugs'. The new epidemic
    Stephen C Koesters
    Department of Internal Medicine, Department of Pediatrics, Ohio State University College of Medicine and Public Health, Columbus Children s Hospital, Columbus, OH, USA
    Pediatr Clin North Am 49:415-33. 2002
    ..Effective education and timely intervention may prevent these addictive drugs from becoming a way of life, a lifestyle that may have a literal "dead end."..
  75. pmc 3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings
    Michael H Baumann
    Clinical Psychopharmacology Section, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 189:407-24. 2007
    ..g., depletion of forebrain 5-HT) that have been interpreted as neurotoxicity. Whether such 5-HT deficits reflect neuronal damage is a matter of ongoing debate...
  76. ncbi Ethanol co-administration moderates 3,4-methylenedioxymethamphetamine effects on human physiology
    G J H Dumont
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Psychopharmacol 24:165-74. 2010
    ..In conclusion, co-administration of ethanol and MDMA did not exacerbate physiologic effects compared to all other drug conditions, and moderated some effects of MDMA alone...
  77. ncbi Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance
    R R Griffiths
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510, Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Psychopharmacology (Berl) 187:268-83; discussion 284-92. 2006
    ..Although psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects...
  78. ncbi Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on behavioral measures of impulsivity: alone and in combination with alcohol
    Johannes G Ramaekers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 31:1048-55. 2006
    ..The lack of interaction indicated that the CNS stimulant effects of MDMA were never sufficient to overcome alcohol-induced impairment of impulse control or risk-taking behavior...
  79. ncbi Subjective and hormonal effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans
    Debra S Harris
    Drug Dependence Research Center, Langley Porter Psychiatric Institute, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143 0984, USA
    Psychopharmacology (Berl) 162:396-405. 2002
    ..3,4-Methylenedioxymethamphetamine (MDMA) is a widely used phenethylamine. Reports have described the effects of MDMA in a controlled laboratory setting, but the full range of effects of MDMA in humans is still not completely characterized...
  80. ncbi MDMA use and neurocognition: a meta-analytic review
    Ari D Kalechstein
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at the University of California, Los Angeles, CA 90024, USA
    Psychopharmacology (Berl) 189:531-7. 2007
    ..To determine the association between MDMA misuse and neurocognition using meta-analysis...
  81. ncbi Localization of MDMA-induced brain activity in healthy volunteers using low resolution brain electromagnetic tomography (LORETA)
    E Frei
    University Hospital of Psychiatry, Zurich, Switzerland
    Hum Brain Mapp 14:152-65. 2001
    ....
  82. ncbi The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis
    DEEPAK CYRIL D'SOUZA
    Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Neuropsychopharmacology 29:1558-72. 2004
    ..These data warrant further study of whether brain cannabinoid receptor function contributes to the pathophysiology of psychotic disorders...
  83. ncbi A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis
    Michael A Benneyworth
    Department of Pharmacology, Vanderbilt University School of Medicine, 8140 MRB III, Nashville, TN 37232, USA
    Mol Pharmacol 72:477-84. 2007
    ..agonists also modulate the in vivo activity of psychotomimetic drugs and reduce the ability of psychotomimetic hallucinogens to increase glutamatergic transmission...
  84. ncbi The neuropsychology of ecstasy (MDMA) use: a quantitative review
    Konstantine K Zakzanis
    Department of Psychology, University of Toronto at Scarborough, Toronto, Ontario, Canada
    Hum Psychopharmacol 22:427-35. 2007
    ..Implications and limitations of these findings are discussed...
  85. ncbi Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex
    Javier Gonzalez-Maeso
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 23:8836-43. 2003
    ..Our results demonstrate that chemicals acting at the 5-HT2AR induce specific cellular response patterns in vivo that are reflected in unique changes in the somatosensory cortex transcriptome...
  86. pmc Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation
    Chiung Wen Chang
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Neuropharmacology 56:213-25. 2009
    ....
  87. ncbi Increasing MDMA use among college students: results of a national survey
    Jared Strote
    Department of Emergency Medicine, Stanford University Medical Center, Stanford, California, USA
    J Adolesc Health 30:64-72. 2002
    ..To examine the prevalence and changing patterns of ecstasy use among college students, and to determine characteristics, associated behaviors, and interests of ecstasy users...
  88. ncbi Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats
    W E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 83:122-9. 2006
    ....
  89. pmc Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents
    William E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 88:358-65. 2008
    ....
  90. ncbi Analysis of the psychoactive terpenoid salvinorin A content in five Salvia divinorum herbal products
    William R Wolowich
    Nova Southeastern University, Fort Lauderdale, Florida 33328, USA
    Pharmacotherapy 26:1268-72. 2006
    ..To determine the content of the hallucinogen salvinorin A in a variety of Salvia divinorum herbal products and to compare the content with the label claims of potency and purity...
  91. ncbi Forensic cases involving the use of GHB in The Netherlands
    Ingrid J Bosman
    Department of Toxicology, Netherlands Forensic Institute, P O Box 3110, 2280 GC Rijswijk, The Netherlands
    Forensic Sci Int 133:17-21. 2003
    ..As GHB is not routinely found during systematical toxicological analyses, these data may seriously underestimate the use of GHB. Therefore, information from the police to the forensic institute is essential...
  92. pmc Neuropsychological function in ecstasy users: a study controlling for polydrug use
    Jonathan P Roiser
    Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Box 189, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 189:505-16. 2007
    ..However, few of those studies controlled adequately for non-ecstasy illicit drug use...
  93. ncbi Involvement of inferior parietal lobules in prospective memory impairment during acute MDMA (ecstasy) intoxication: an event-related fMRI study
    Johannes G Ramaekers
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 34:1641-8. 2009
    ..It is concluded that the loss of deactivation in inferior parietal lobules may account for increments in memory failures observed during MDMA intoxication...
  94. ncbi Acute and long-term effects of MDMA on cerebral dopamine biochemistry and function
    M Isabel Colado
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    Psychopharmacology (Berl) 173:249-63. 2004
    ..The objective of this review is to examine the actions of MDMA on dopamine biochemistry and function in mice, rats, guinea pigs, monkeys and humans...
  95. ncbi Is ecstasy MDMA? A review of the proportion of ecstasy tablets containing MDMA, their dosage levels, and the changing perceptions of purity
    A C Parrott
    Department of Psychology, University of Wales Swansea, Swansea, SAZ 8PP, United Kingdom
    Psychopharmacology (Berl) 173:234-41. 2004
    ..The historical origins and evolution of this mismatch will be reviewed, in order to estimate the proportions of ecstasy tablets containing MDMA at different periods over the past 30 years...
  96. ncbi Theory of planned behaviour and ecstasy use: an analysis of moderator-interactions
    Kanayo Umeh
    Department of Social Sciences, Nottingham Trent University, UK
    Br J Health Psychol 9:25-38. 2004
    ..It was expected that attitudes, subjective norms and perceived behavioural control (PBC) would moderate each other in predicting intended use of this drug...
  97. pmc The stimulus properties of LSD in C57BL/6 mice
    J C Winter
    Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, 102 Farber Hall, Buffalo, NY 14214 3000, USA
    Pharmacol Biochem Behav 81:830-7. 2005
    ..Lysergic acid diethylamide [LSD], the prototypic indoleamine hallucinogen, has not previously been trained as a discriminative stimulus in mice...
  98. ncbi Club drugs: MDMA, gamma-hydroxybutyrate (GHB), Rohypnol, and ketamine
    Paul M Gahlinger
    Department of Family and Preventive Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Am Fam Physician 69:2619-26. 2004
    ..Severe drug reactions can occur even with a small dose and may require critical care. Club drug over-dose usually resolves with full recovery within seven hours. Education of the patient and family is essential...
  99. ncbi The confounding problem of polydrug use in recreational ecstasy/MDMA users: a brief overview
    Euphrosyne Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University of Cologne, Germany
    J Psychopharmacol 20:188-93. 2006
    ....
  100. ncbi Cognitive function and mood in MDMA/THC users, THC users and non-drug using controls
    C T J Lamers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Brain and Behaviour Institute, Maastricht University, The Netherlands
    J Psychopharmacol 20:302-11. 2006
    ..THC users were impaired in some cognitive abilities to the same degree as MDMA/THC users, suggesting that some cognitive impairment attributed to MDMA is more likely due to concurrent THC use...
  101. ncbi The rise of club drugs in a heroin society: the case of Hong Kong
    Karen A Joe Laidler
    Sociology Department and Centre for Criminology, University of Hong Kong, Hong Kong
    Subst Use Misuse 40:1257-78. 2005
    ....

Research Grants63

  1. Structural Domains Essential for Serotonin Receptor Pharmacology
    Bryan Roth; Fiscal Year: 2006
    ..studies are of clinical significance because activation of 5-HT2A receptors is responsible for the actions of hallucinogens (e.g...
  2. Metabolism and Pharmacogenetics in MDMA-Induced Toxicity
    Rafael de la Torre; Fiscal Year: 2009
    ..3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is a synthetic compound structurally related to stimulants and hallucinogens. In the United States, in 2001, an estimated 3...
  3. Serotonergic modulation of claustro-cortical circuits
    Jay A Gingrich; Fiscal Year: 2013
    ..The tools and results from this study can be used in the future to directly manipulate neuronal activity of the CL and reveal new neural substrates of serotonergic action on emotional and cognitive function. ..
  4. MONOAMINE AND HALLUCINOGEN EFFECTS ON RODENT BEHAVIOR
    Mark A Geyer; Fiscal Year: 2013
    ..Based on the profound effects of hallucinogens on responses to sensory and emotional stimuli in humans, hallucinogenic drug effects in rats and mice are ..
  5. Physiological Implications of Serotonin Receptor Regulation
    Laura M Bohn; Fiscal Year: 2013
    ..The serotonin 2A receptor is also a prominent target for drugs of abuse, particularly those classified as hallucinogens;lysergic acid diethylamide (LSD) mediates its hallucinogenic effects by directly activating this receptor...
  6. Clinical Pharmacology/Mechanisms of Action of Emerging Abused Drugs (Club Drugs)
    Roland R Griffiths; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Recreational abuse of newly emerging "club drugs" including atypical hallucinogens, which is exacerbated by internet websites, is a significant and growing national problem...
  7. Chemistry and Pharmacology of Newly Emerging Psychoactive Plants
    Jordan K Zjawiony; Fiscal Year: 2010
    ..This use of new hallucinogens unregulated by Federal and most State laws is spreading across the country and globally...
  8. Partners for Strong, Healthy Families (PSHF)
    Frank H Galvan; Fiscal Year: 2013
    ..their White or Black peers to report lifetime past-year or past-month use of marijuana, cocaine, crack, and hallucinogens (Johnston, O'Malley, Bachman, &Schulenberg, 2010)...
  9. Ligand-Specific Allosteric Modulation by Drugs of Abuse
    MICHAEL VINCENT LEVINE; Fiscal Year: 2013
    ..I will produce new experimentally testable hypotheses and work with experimental collaborators in the design of new types of experiments aimed at expanding the understanding the mechanisms of such drugs and medications. ..
  10. Evaluation of Mouse Hallucinations by fMRI
    Paul H Patterson; Fiscal Year: 2012
    ..Using surrogate histological measures of neuronal activity, it appears that the mouse brain responds to hallucinogens in a manner similar to the human...
  11. Developing adult zebrafish-based models to study hallucinogenic drug action
    Allan V Kalueff; Fiscal Year: 2012
    ..This lack of knowledge, combined with the profound cognitive and behavioral effects of hallucinogens, mandate a need to develop novel approaches to gain a more comprehensive understanding of the behavioral ..
  12. The Times are Changing: A Qualitative Study of Older and Younger Marijuana Users
    SHEIGLA BRIGHID MURPHY; Fiscal Year: 2013
    ....
  13. Impact of cholinergic plant extracts on nociception
    ERIC WIERTELAK; Fiscal Year: 2005
    ..This study will also examine the pain alterations caused by non-cholinergic hallucinogens, to determine whether changes in pain responsivity seen caused by extracts and alkaloids result from their ..
  14. Conference-College on Problems of Drug Dependence
    Martin Adler; Fiscal Year: 2009
    ..including opioids, cocaine, methamphetamine, cannabinoids, nicotine, inhalants, alcohol, sedative-hypnotics, hallucinogens, and club drugs. No other meeting covers the breadth of research in the drug abuse field...
  15. Classification of substance use disorders in adolescents
    LI TZY T WU; Fiscal Year: 2013
    ..to the use or abuse of alcohol, cigarettes, inhalants, marijuana, cocaine, heroin, stimulants, opioids, and hallucinogens/MDMA, as well as the factors associated with the utilization of substance abuse treatment services...
  16. Annual Meeting of College on Problems of Drug Dependence
    Martin W Adler; Fiscal Year: 2013
    ..including opioids, cocaine, methamphetamine, cannabinoids, nicotine, inhalants, alcohol, sedative-hypnotics, hallucinogens, and club drugs. No other meeting covers the breadth of research in the drug abuse field...
  17. Targeting and Trafficking of 5-HT2A serotonin Receptors
    Bryan L Roth; Fiscal Year: 2013
    ..many psychiatric and non-psychiatric medications including atypical antipsychotics, certain antidepressants, hallucinogens and some appetite suppressants our studies could lead to novel therapeutic strategies for many therapeutic ..
  18. NOVEL PALLADIUM CATALYZED SYNTHESES OF INDOLE ALKALOIDS
    BJORN SODERBERG; Fiscal Year: 2001
    ..nosiheptide (antibiotic), LY-311727 (s-PLA2 inhibitor), BE 10988 (topoisomerase II inhibitor), 7- bromo-eudistomin D (antiviral), bufotenine (hallucinogens), spider venoms (neurotoxins), damirone C and CC-1065 (cytotoxins) are proposed.
  19. 5 HYDROXTRYPTAMINE MECHANISMS OF HALLUCINOGENIC DRUGS
    DAVID MOKLER; Fiscal Year: 1992
    ..for over 20 years and have provided new opportunities for advancing our understanding of the actions of the hallucinogens. The method of in vivo microdialysis for simultaneous measurement of the extracellular levels of 5-HT and its ..
  20. DISTINCTIVE RECEPTOR ACTIONS IN HALLUCINOGEN MECHANISMS
    Harel Weinstein; Fiscal Year: 2011
    ..modes of interaction with these receptors, that produce distinct molecular signaling mechanisms; thus, hallucinogens trigger structural and dynamic receptor responses (affecting protein-protein interactions) that differ from ..
  21. STIMULANTS, DEPRESSANTS & HALLUCINOGENS AS REINFORCERS
    Gail Winger; Fiscal Year: 2003
    ..attempt to understand more of the factors that lead to and result from abuse of stimulants, depressants, and hallucinogens. 1...
  22. Diterpines as Selective Kappa Opioid Receptor Agonists
    Bryan L Roth; Fiscal Year: 2013
    ..divinorum induce an intense and short-lived hallucinatory experience in humans unlike that of the classical hallucinogens LSD, psilocybin and mescaline...
  23. B CARBOLINE HALLUCINOGENS
    RICHARD GLENNON; Fiscal Year: 1999
    The beta-carboline hallucinogens remain as the last category of classical hallucinogenic agents that has not been studied in a systematic and comprehensive manner...
  24. TAS::75 0893::TAS SYNTHESIS AND DISTRIBUTION OF OPIOID AND RELATED PEPTIDES
    JEANICK PASCAL; Fiscal Year: 2011
    ..Such drugs and chemicals include marijuana and marijuana cigarettes, various cannabinoids, known hallucinogens, heroin, amphetamines, and many others that are essential for pre-clinicla and clinical research...
  25. NEUROTOXIC HALLUCINOGENS: EFFECTS ON LEARNING
    John Harvey; Fiscal Year: 1992
    ..Recently, two other penethylamine hallucinogens 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethamphetamine (MDMA) have been demonstrated to ..
  26. NEUROHUMORAL DETERMINANTS OF SENSITIVITY TO DRUGS
    JAMES APPEL; Fiscal Year: 1991
    ..is to assess the neuronal mechanisms underlying certain behavioral effects of indole- and phenylalkylamine hallucinogens (e.g...
  27. SYNTHETIC PEPTIDES PURITY DETERMINATION, STABILITY TEST
    KANTHI HETTIARACHCHI; Fiscal Year: 2000
    ..These include known hallucinogens, heroin, amphetamines, cannabinoids, and many other drugs essential for both clinical and laboratory research ..
  28. SYNTHETIC PEPTIDES AS STRUCTURAL PROBES FOR PRECLINICAL
    GEORGE BRINE; Fiscal Year: 2000
    ..These include marijuana cigarettes, known hallucinogens, heroin, amphetamines, cannabinoids, and many other drugs essential for both clinical and laboratory research ..
  29. SYNTHESIS AND DISTRIBUTION OF OPIOID & RELATED PEPTIDES
    Richard Houghten; Fiscal Year: 2000
    ..These include marijuana cigarettes, known hallucinogens, heroin, amphetamines, cannabinoids, and many other drugs essential for both clinical and laboratory -research ..
  30. Hallucinogen self-administration in baboons
    AMY GOODWIN; Fiscal Year: 2009
    ..provided by applicant): Although there has been a revived interest in the possible therapeutic effects of hallucinogens (Griffiths et al. 2006;Nichols 2004), such drugs are also popular drugs of abuse...
  31. Serotonin Glutamate Interactions in Prefrontal Cortex
    Gerard Marek; Fiscal Year: 2001
    ..As such, this multi-disciplinarian study may provide new strategies to develop novel antidepressant treatments that would be more efficacious than simply blocking 5-HT2A receptors. ..
  32. QUANTITATIVE ANALYSIS OF A METHOD DEVELOPMENT FOR CANN
    C Cook; Fiscal Year: 2000
    ..These included marijuana cigarettes, known, known hallucinogens, heroin, amphetamines, cannabinoids, and many other drugs essential for both clinical and laboratory research ..
  33. CHEMICAL PHARMACOLOGY OF MDA AND MDMA
    Arthur Cho; Fiscal Year: 1992
    ..These compounds are members of the phenylisopropylamine class of stimulants and hallucinogens that have a long history of abuse...
  34. CHEMICAL/BEHAVIORAL STUDIES ON HALLUCINOGENIC AGENTS
    RICHARD GLENNON; Fiscal Year: 2007
    ..in rats: a 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane-like (D(c)M-like) effect typical of classical hallucinogens (H), a (+)amphetamine-like effect typical of stimulants (S), and a third type of effect that has not yet been ..
  35. REGIOSPECIFIC SYNTHESIS OF SUBSTITUTED INDOLES
    STANLEY RAUCHER; Fiscal Year: 1980
    ..in a variety of biologically active molecules including the important neurotransmitter serotonin, the potent hallucinogens psilocybin and LSD, the hypotensive and tranquilizer reserpine, and the CNS stimulant harmaline...
  36. HALLUCINOGENS IN MODELS OF BRAIN SEROTONIN ACTIVITY
    John Connor; Fiscal Year: 1980
    ..with models of serotonin receptor activation to the extent they can be used to probe for basic mechanisms for hallucinogens. The influence exerted by the drugs on serotonin mechanisms are being studied two ways: with a rat behavioral ..
  37. Prescription Drug Abuse in Adolescents and Young Adults
    Linda Simoni Wastila; Fiscal Year: 2005
    ..past-year non-medical prescription drug use that exceeded the combined use of heroin, cocaine, crack, and hallucinogens. Among those aged 12-17, non-medical prescription drug use increased by 11...
  38. PHARMACOLOGY OF NARCOTICS & NARCOTIC ANTAGONISTS
    JAMES MC KEARNEY; Fiscal Year: 1991
    ..and elsewhere has shown that the opioid antagonist naloxone markedly enhances the behavioral effects of hallucinogens, and there are suggestions that opioid agonists such as morphine have the opposite effect...
  39. Molecular Neurobiology of Drug Abuse
    DONALD KUHN; Fiscal Year: 2006
    ..Kuhn will remain extensively engaged in scientific mentoring activities. ..
  40. Brief Intervention for Drug Abuse Using the WHO ASSIST
    Thomas Babor; Fiscal Year: 2006
    ..to screen for problem or risky use of tobacco, alcohol, cannabis, cocaine, amphetamines, sedatives, hallucinogens, inhalants, opiates and other drugs...
  41. SYNTHESIS/DISTRIBUTION OF DRUGS OF ABUSE AND OPIODS
    F Carroll; Fiscal Year: 2000
    ..These include marijuana cigarettes, known hallucinogens, heroin, amphetamines, cannabinoids, and many other drugs essential for both clinical and laboratory research ..
  42. PSYCHOTOGENIC DRUG ACTION ON CHEMICALLY DEFINED NEURONS
    George Aghajanian; Fiscal Year: 2000
    ..investigation of the electrophysiological actions of the indoleamine/phenethethylamine class of psychedelic hallucinogens on identified neurons of the rat brain. Specific aims are: 1...
  43. 5-HT1A receptor and hallucinogens
    CHAD REISSIG; Fiscal Year: 2005
    The use of hallucinogens in our society, particularly adolescents and young adults, continues to be widespread and is thus a major interest of the National Institute on Drug Abuse...
  44. HALLUCINOGEN ANALOGUES: 1,2-DIHYDRO-2-NAPHTHYLAMINES
    David Nichols; Fiscal Year: 1980
    ..may be useful models to relate the structural and functional similarities between phenethylamine type hallucinogens, such as mescaline, and the tryptamine hallucinogens, such as LSD...
  45. SENSORY, ASSOCIATIVE & MOTOR EFFECTS OF DRUGS OF ABUSE
    ISIDORE GORMEZANO; Fiscal Year: 1990
    We propose to extend substantially our investigations into the manner by which hallucinogens and opiates later sensory, associative and motor processes by seeking to determine their effects upon temporal, motivational, associative memory ..
  46. MABS SPECIFIC TO SEROTONIN 5-HT RECEPTORS
    Sujay Singh; Fiscal Year: 1999
    ..Since the field of serotonin research field is large and more than 27,000 articles with potential significance for clinical application have been published in the last ten years, we predict the market to be of a reasonable size. ..
  47. Effect of Treatment for Drug-Abusing Fathers on Children
    Michelle Kelley; Fiscal Year: 2005
    ..2002). Men are more likely to abuse substances (including marijuana, hallucinogens, and heroin) than are women (Department of Health and Human Services, 2002), and data suggest that the number ..
  48. Ethnopharmacological Approach to Psychoactive Compounds
    Hernan Navarro; Fiscal Year: 2009
    ..We will also include the novel target, human trace amine associated receptor 1, which is activated by known hallucinogens. 3) Prioritize the samples that hit based on their receptor profile...
  49. BRAIN STRUCTURE AND FUNCTION AFTER DRUGS OF ABUSE
    ROBERT SLOVITER; Fiscal Year: 1990
    ..The biomedical impact of preventing drug-induced brain damage, if it occurs, would be considerable...
  50. SMALL ANIMAL PET SCANNER
    Robert Kessler; Fiscal Year: 2003
    ..It will be sited physically within the PET Center administratively within the newly formed Center for Research Imaging under the Direction of Dr. John Gore. ..
  51. A MULTIDISCIPLINARY STUDY OF DRUGS OF ABUSE
    LOUIS HARRIS; Fiscal Year: 1993
    ..We will then extend these findings to other cannabinoids as well as other classes of hallucinogens. We plan to continue our efforts to develop methods for better evaluating the reinforcing efficacy of drugs of ..
  52. PREPARATION OF STANDARDIZED NICOTINE AND CIGARETTES
    Ram Murty; Fiscal Year: 2000
    ..These include marijuana, known hallucinogens, heroin, amphetamines, cannabinoids, opiates, neuropeptides, and many other chemicals, and drugs essential ..
  53. Hallucinogens--Serotonergic Glutamatergic Interactions
    Meredith Regina; Fiscal Year: 2003
    ..the serotonergic-glutamatergic interaction in drug-induced stimulus control by indoleamine and phenethylamine hallucinogens and (ii) to determine the molecular mechanisms involved in this interaction...
  54. Mechanisms of hallucinogen specific neuronal response
    Rosalind Ang; Fiscal Year: 2009
    The serotonin 2A receptor (5HT2AR) has been established as the key receptor to be involved in the actions of hallucinogens. Our group has recently reported hallucinogens induce a unique gene expression profile in the somatosensory cortex ..
  55. FLUORESCENT PROBES FOR BRAIN SEROTONIN RECEPTORS
    JOHN NEUMEYER; Fiscal Year: 1992
    ..Neural membranes at various levels of tissue organization will be exposed to the fluorescent probe, photobleached by laser beam, and the recovery of fluorescence will be monitored by fluorescence microscopy...
  56. PREPARATION
    Kenneth Davis; Fiscal Year: 2000
    ..These drugs include but not limited to known hallucinogens, heroin, amphetamines, cannabinoids, and many other drugs essential for both clinical and non-clinical ..
  57. 5HT2 Selective Ligands Guided by Receptor Variants
    Teresa Bennett; Fiscal Year: 2003
    The three 5HT2 receptors have been implicated in many disease states, including drugs of abuse such as hallucinogens. However, their close similarity has hindered the development of truly subtype-selective ligands...
  58. Behavioral Pharmacology of Serotonin Inverse Agoinsts
    Ellen Walker; Fiscal Year: 2006
    ..drugs with affinity for serotonin 2C (5-HT2C) receptors is critical to the characterization of these drugs as hallucinogens, antipsychotics, and antidepressants...
  59. HUMAN PSYCHOPHARMACOLOGY & NEUROENDOCRINOLOGY OF DMT
    Rick Strassman; Fiscal Year: 1991
    ..b>Hallucinogens continue being abused, particularly by young adults...
  60. PROBLEMS OF DRUG DEPENDENCE
    Thomas Crowley; Fiscal Year: 1993
    ..Finnegan) Recent Research on Hallucinogens (Dr. Glennon) Opioid Receptors: Molecular and Structural Studies (Drs...
  61. COGNITIVE EFFECTS OF SUBSTANCE USE IN NATIVE AMERICANS
    John Halpern; Fiscal Year: 2003
    ..on substance abuse, most recently a critical review of studies of the long-term neuropsychological effects of hallucinogens-a class of drugs increasing in popularity among high school students and young adults, 1,2 yet still ..
  62. Neurocognitive Consequences of Long-Term Ecstasy Use
    John Halpern; Fiscal Year: 2008
    ..The results of this study will improve our understanding of the nature, extent, and correlates of ecstasy-associated residual cognitive deficits. ..
  63. Effects of self-administered MDMA on brain and behavior in rhesus monkeys
    William Fantegrossi; Fiscal Year: 2007
    ..Thus, these studies are likely to be more relevant to the potential human condition of MDMA-induced lasting neurochemical alterations and behavioral changes [unreadable] [unreadable]..