narcotics

Summary

Summary: Originally, agents that caused somnolence or induced sleep; now, any derivative, natural or synthetic, of opium or morphine or any substance that has their effects. Narcotics have potent analgesic effects associated with significant changes in mood and behavior, and with the potential for dependence and tolerance following repeated administration. (Stedman, 25th ed)

Top Publications

  1. ncbi Leaving methadone treatment: lessons learned, lessons forgotten, lessons ignored
    S Magura
    National Development and Research Institutes, Inc, Two World Trade Center, 16th Floor, New York, NY 10048, USA
    Mt Sinai J Med 68:62-74. 2001
  2. ncbi The impact of ongoing illicit drug use on methadone adherence in illicit drug users receiving treatment for HIV in a directly observed therapy program
    Jesse D Raffa
    Department of Statistics, University of British Columbia, Vancouver, BC, Canada
    Drug Alcohol Depend 89:306-9. 2007
  3. ncbi Quality of life among heroin users on buprenorphine versus methadone maintenance
    Alexander M Ponizovsky
    Mental Health Services, Ministry of Health, Jerusalem, Israel
    Am J Drug Alcohol Abuse 33:631-42. 2007
  4. ncbi The effects of illicit drugs on the HIV infected brain
    Iain Crawford Anthony
    Division of Pathology Neuropathology, University of Edinburgh, Alexander Donald Building, Western General Hospital, Edinburgh, EH4 2XU, UK
    Front Biosci 13:1294-307. 2008
  5. ncbi Modulation of immune function by morphine: implications for susceptibility to infection
    Sabita Roy
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    J Neuroimmune Pharmacol 1:77-89. 2006
  6. ncbi The efficacy of methadone maintenance interventions in reducing illicit opiate use, HIV risk behavior and criminality: a meta-analysis
    L A Marsch
    Towson State University, Department of Psychology, Maryland, USA
    Addiction 93:515-32. 1998
  7. ncbi Molecular basis for interactions of HIV and drugs of abuse
    Avi Nath
    Department of Neurology, John Hopkins University, Baltimore, Maryland 21287, USA
    J Acquir Immune Defic Syndr 31:S62-9. 2002
  8. ncbi White matter impairment in heroin addicts undergoing methadone maintenance treatment and prolonged abstinence: a preliminary DTI study
    Yarong Wang
    Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, 1 Xinsi Road, Baqiao District, Xi an 710038, China
    Neurosci Lett 494:49-53. 2011
  9. ncbi Heroin-assisted treatment in Switzerland: a case study in policy change
    Ambros Uchtenhagen
    Research Institute on Public Health and Addiction at Zurich University, Zurich, Switzerland
    Addiction 105:29-37. 2010
  10. ncbi Activation of stress-related hypothalamic neuropeptide gene expression during morphine withdrawal
    Cristina Nunez
    Department of Pharmacology, University of Murcia, Murcia, Spain
    J Neurochem 101:1060-71. 2007

Detail Information

Publications289 found, 100 shown here

  1. ncbi Leaving methadone treatment: lessons learned, lessons forgotten, lessons ignored
    S Magura
    National Development and Research Institutes, Inc, Two World Trade Center, 16th Floor, New York, NY 10048, USA
    Mt Sinai J Med 68:62-74. 2001
    ....
  2. ncbi The impact of ongoing illicit drug use on methadone adherence in illicit drug users receiving treatment for HIV in a directly observed therapy program
    Jesse D Raffa
    Department of Statistics, University of British Columbia, Vancouver, BC, Canada
    Drug Alcohol Depend 89:306-9. 2007
    ..We sought to evaluate the impact of ongoing illicit drug use on methadone adherence within a DOT program for the treatment of HIV-infection...
  3. ncbi Quality of life among heroin users on buprenorphine versus methadone maintenance
    Alexander M Ponizovsky
    Mental Health Services, Ministry of Health, Jerusalem, Israel
    Am J Drug Alcohol Abuse 33:631-42. 2007
    ..To assess the quality of life (QoL) of heroin users starting and following 4 and 8 months of maintenance treatment program using buprenorphine vs. methadone...
  4. ncbi The effects of illicit drugs on the HIV infected brain
    Iain Crawford Anthony
    Division of Pathology Neuropathology, University of Edinburgh, Alexander Donald Building, Western General Hospital, Edinburgh, EH4 2XU, UK
    Front Biosci 13:1294-307. 2008
    ..The additional impact of intravenous drug abuse on HIV-associated brain disease, then and now, is also reviewed. Predictions for the future are discussed, based on what is known at present and on recently emerging data...
  5. ncbi Modulation of immune function by morphine: implications for susceptibility to infection
    Sabita Roy
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    J Neuroimmune Pharmacol 1:77-89. 2006
  6. ncbi The efficacy of methadone maintenance interventions in reducing illicit opiate use, HIV risk behavior and criminality: a meta-analysis
    L A Marsch
    Towson State University, Department of Psychology, Maryland, USA
    Addiction 93:515-32. 1998
    ....
  7. ncbi Molecular basis for interactions of HIV and drugs of abuse
    Avi Nath
    Department of Neurology, John Hopkins University, Baltimore, Maryland 21287, USA
    J Acquir Immune Defic Syndr 31:S62-9. 2002
    ..This article also suggests therapeutic approaches based on our current understanding of the neuropathogenesis of dementia due to HIV infection and drugs of abuse...
  8. ncbi White matter impairment in heroin addicts undergoing methadone maintenance treatment and prolonged abstinence: a preliminary DTI study
    Yarong Wang
    Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, 1 Xinsi Road, Baqiao District, Xi an 710038, China
    Neurosci Lett 494:49-53. 2011
    ..Our preliminary results suggest that methadone plays a role in the impairment of WM integrity in heroin users on long-term MMT and the normalization of WM injury may occur during abstinence...
  9. ncbi Heroin-assisted treatment in Switzerland: a case study in policy change
    Ambros Uchtenhagen
    Research Institute on Public Health and Addiction at Zurich University, Zurich, Switzerland
    Addiction 105:29-37. 2010
    ..The high visibility of 'needle parks' and the size of the acquired immune deficiency disorder (AIDS) epidemic called for a new approach and for national leadership...
  10. ncbi Activation of stress-related hypothalamic neuropeptide gene expression during morphine withdrawal
    Cristina Nunez
    Department of Pharmacology, University of Murcia, Murcia, Spain
    J Neurochem 101:1060-71. 2007
    ..These activations however were not associated with induction of CRH or AVP hnRNAs...
  11. ncbi The impact of needle and syringe provision and opiate substitution therapy on the incidence of hepatitis C virus in injecting drug users: pooling of UK evidence
    Katy M E Turner
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Addiction 106:1978-88. 2011
    ..To investigate whether opiate substitution therapy (OST) and needle and syringe programmes (NSP) can reduce hepatitis C virus (HCV) transmission among injecting drug users (IDUs)...
  12. ncbi Anesthesia for a patient with morbid obesity using dexmedetomidine without narcotics
    Roger E Hofer
    Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First Street S W, Rochester, MN 55905, USA
    Can J Anaesth 52:176-80. 2005
    ..To describe the anesthetic management of a patient with extreme obesity undergoing bariatric surgery whose intraoperative narcotic management was entirely substituted with dexmedetomidine...
  13. ncbi Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone
    Paul J Fudala
    Veterans Affairs VA Medical Center, University of Pennsylvania School of Medicine, Philadelphia, USA
    N Engl J Med 349:949-58. 2003
    ..Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone has been proposed, but its efficacy and safety have not been well studied...
  14. ncbi Association between non-medical and prescriptive usage of opioids
    Nabarun Dasgupta
    Risk Management and Health Policy, Purdue Pharma L P, One Stamford Forum, Stamford, CT 06901 3431, USA
    Drug Alcohol Depend 82:135-42. 2006
    ..9791) with the reported morbidity for prescription analgesics as a class, as measured in the DAWN system. These data suggest that non-medical use of opioids is predictable based on potency and extent of prescriptive use...
  15. ncbi Opioids, opioid receptors, and the immune response
    L McCarthy
    Department of Microbiology and Immunology, Temple University School of Medicine, 3400 N. Broad Street, Philadelphia, PA 19140, USA
    Drug Alcohol Depend 62:111-23. 2001
    ..Future research should provide a clearer understanding of the cellular and molecular targets of opioid action within the immune system...
  16. pmc Survival and cessation in injecting drug users: prospective observational study of outcomes and effect of opiate substitution treatment
    Jo Kimber
    Department of Social Medicine, University of Bristol, Bristol BS8 2PS
    BMJ 341:c3172. 2010
    ..To examine survival and long term cessation of injecting in a cohort of drug users and to assess the influence of opiate substitution treatment on these outcomes...
  17. pmc Glutamatergic substrates of drug addiction and alcoholism
    Justin T Gass
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Biochem Pharmacol 75:218-65. 2008
    ..Nonetheless, manipulation of glutamatergic neurotransmission appears to be a promising avenue of research in developing improved therapeutic agents for the treatment of drug addiction and alcoholism...
  18. ncbi Psychiatric comorbidity reduces quality of life in chronic methadone maintained patients
    Pieter J Carpentier
    Novadic Kentron, Network for Addiction Treatment Services, Vught, The Netherlands
    Am J Addict 18:470-80. 2009
    ..Such comorbid psychopathology substantially affects quality of life. The negative influence of comorbid psychopathology on quality of life is an important reason to provide additional mental health services for MMT patients...
  19. ncbi Antagonism of orexin type 1 receptors in the locus coeruleus attenuates signs of naloxone-precipitated morphine withdrawal in rats
    Hossein Azizi
    Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, PO Box 14115 331, Tehran, IR, Iran
    Neurosci Lett 482:255-9. 2010
    ..These results suggest that activation of OXR1 in the LC might be involved in the expression of withdrawal signs in morphine dependent rats...
  20. ncbi Blocking α4β2 and α7 nicotinic acetylcholine receptors inhibits the reinstatement of morphine-induced CPP by drug priming in mice
    Bin Feng
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an 710032, China
    Behav Brain Res 220:100-5. 2011
    ..The data suggest that specific nAChR subtypes, i.e., α(4)β(2) and α(7), may contribute to the reinstatement of morphine-induced CPP by drug priming in mice...
  21. pmc Predictors of methadone treatment retention from a multi-site study: a survival analysis
    Sharon M Kelly
    Friends Research Institute, Inc, 1040 Park Avenue, Baltimore, MD 21201, USA
    Drug Alcohol Depend 117:170-5. 2011
    ..Longer tenure in methadone treatment has been associated with positive outcomes such as reductions in drug use and crime, HIV seroconversion, and overdose death...
  22. ncbi Time-dependent changes in extinction behavior and stress-induced reinstatement of drug seeking following withdrawal from heroin in rats
    U Shalev
    Behavioral Neuroscience Branch, IRP/NIDA/NIH, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 156:98-107. 2001
    ..Finally, the time-dependent changes in footshock stress-induced reinstatement following withdrawal from heroin were not correlated with alterations in CRF mRNA in the CeA and BNST...
  23. ncbi Misconceptions predict dropout and poor adherence prospectively among newly admitted first-time methadone maintenance treatment clients in Guangzhou, China
    Jing Gu
    School of Public Health, Sun Yat Sen University, Guangzhou, China
    Addiction 107:1641-9. 2012
    ....
  24. ncbi The comparative toxicology and major organ pathology of fatal methadone and heroin toxicity cases
    Shane Darke
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW 2052, Australia
    Drug Alcohol Depend 106:1-6. 2010
    ....
  25. pmc 30-year trajectories of heroin and other drug use among men and women sampled from methadone treatment in California
    Christine E Grella
    UCLA Integrated Substance Abuse Programs, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90025, USA
    Drug Alcohol Depend 118:251-8. 2011
    ..This study examines 30-year trajectories of heroin and other drug use among men and women who were in methadone maintenance treatment in California in the late 1970s and interviewed in 1978-1981...
  26. pmc Toll-like receptor expression and activation in astroglia: differential regulation by HIV-1 Tat, gp120, and morphine
    Nazira El-Hage
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, USA
    Immunol Invest 40:498-522. 2011
    ..The results suggest that HIV-1 proteins and/or opioid abuse disrupt the innate immune response of the central nervous system (CNS) which may lead to increased pathogenicity...
  27. ncbi HIV infection as a predictor of methadone maintenance outcomes in Chinese injection drug users
    Lin Zhao
    Community Health Systems, University of California, San Francisco, CA, USA
    AIDS Care 24:195-203. 2012
    ..The primary implication of these findings is that HIV positive persons in methadone treatment may require more focused services to meet their special HIV care and substance treatment needs...
  28. ncbi Factors associated with incarceration and incident human immunodeficiency virus (HIV) infection among injection drug users participating in an HIV vaccine trial in Bangkok, Thailand, 1999-2003
    Pravan Suntharasamai
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Addiction 104:235-42. 2009
    ..To determine if incarceration was associated with human immunodeficiency virus (HIV) infection and identify risk factors for incarceration among injection drug users (IDUs) participating in an HIV vaccine trial in Bangkok...
  29. ncbi Synergistic increases in intracellular Ca2+, and the release of MCP-1, RANTES, and IL-6 by astrocytes treated with opiates and HIV-1 Tat
    Nazira El-Hage
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    Glia 50:91-106. 2005
    ....
  30. pmc Risk of death during and after opiate substitution treatment in primary care: prospective observational study in UK General Practice Research Database
    Rosie Cornish
    School of Social and Community Medicine, University of Bristol, Bristol BS8 2PS, UK
    BMJ 341:c5475. 2010
    ..To investigate the effect of opiate substitution treatment at the beginning and end of treatment and according to duration of treatment...
  31. ncbi Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system
    Blandine Pommier
    Departement de Pharmacochimie Moleculaire et Structurale, Institut National de la Santé et de la Recherche Médicale U266 Centre National de la Recherche Scientifique Unité Mixte de Recherche 8600, Paris Cedex 06, France
    J Neurosci 22:2005-11. 2002
    ..These biochemical and pharmacological results demonstrate the critical role played by CCK2 receptors in opioid-dependent responses...
  32. ncbi Cytoskeletal genes regulation by chronic morphine treatment in rat striatum
    Cynthia Marie-Claire
    Departement de Pharmacochimie Moleculaire et Structurale, Universite Rene Descartes Paris V, Paris, France
    Neuropsychopharmacology 29:2208-15. 2004
    ..These results demonstrate that neuroadaptation to chronic morphine administration in rat striatum implies modifications of the expression pattern of several genes and proteins of the cytoskeleton and cytoskeleton-associated components...
  33. ncbi Dissociation between rewarding and psychomotor effects of opiates: differential roles for glutamate receptors within anterior and posterior portions of the ventral tegmental area
    Maytal Shabat-Simon
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 28:8406-16. 2008
    ..These findings suggest a critical role for glutamate receptors in the VTA in opiate reward, as well as behavioral and anatomical dissociation between the rewarding and psychomotor effects of opiates...
  34. pmc Morphine modulation of thrombospondin levels in astrocytes and its implications for neurite outgrowth and synapse formation
    Hiroko Ikeda
    E A Doisy Department of Biochemistry and Molecular Biology, St Louis University, St Louis, Missouri 63104, USA
    J Biol Chem 285:38415-27. 2010
    ..Both of these variations of classical EGFR transactivation may enable opiates to diminish neurite outgrowth and synapse formation...
  35. ncbi Substance use and quality of life over 12 months among buprenorphine maintenance-treated and methadone maintenance-treated heroin-addicted patients
    Icro Maremmani
    Vincent P Dole Research Team, Department of Psychiatry NPB, Santa Chiara University Hospital, University of Pisa, Pisa, Italy
    J Subst Abuse Treat 33:91-8. 2007
    ..This study suggests the long-term efficacy of methadone treatment and buprenorphine treatment on symptoms of opioid addiction and quality of life...
  36. ncbi Secrets of the opium poppy revealed
    Christopher J Evans
    Center for Opioid Receptors and Drugs of Abuse, UCLA NPI Hatos Research Center for Neuropharmacology, NPI Psychiatry, 760 Westwood Plaza, Los Angeles, CA 90265, USA
    Neuropharmacology 47:293-9. 2004
    ....
  37. ncbi First case of stress cardiomyopathy as a result of methadone withdrawal secondary to drug-drug interaction
    Frédéric Lemesle
    Amilly Hospital, France
    Am J Emerg Med 28:387.e5-6. 2010
    ..To our knowledge, this is the first case of stress cardiomyopathy described after abrupt opiate withdrawal secondary to a drug-drug interaction...
  38. ncbi CYP2B6 and OPRM1 gene variations predict methadone-related deaths
    Hannah Bunten
    Centre for Forensic Sciences, Bournemouth University, UK
    Addict Biol 16:142-4. 2011
    ..Screening for these susceptibility variations prior to methadone prescription could assist in reducing the potential for serious adverse effects...
  39. ncbi Morphine inhibits Fc-mediated phagocytosis through mu and delta opioid receptors
    N Tomassini
    Department of Biology, University of Puerto Rico, Rio Piedras Campus, PO Box 23360, San Juan, Puerto Rico 00931 3360, USA
    J Neuroimmunol 147:131-3. 2004
  40. ncbi Change in quality of life and its predictors in heroin users receiving methadone maintenance treatment in Taiwan: an 18-month follow-up study
    Peng Wei Wang
    Department of Psychiatry, Kaohsiung Medical University Hospital, Taiwan
    Am J Drug Alcohol Abuse 38:213-9. 2012
    ..Therefore, it is of clinical benefit to examine what factors can predict a change in QOL among heroin users in the course of a methadone maintenance treatment (MMT) program...
  41. pmc Sudden death in an adult taking methadone: lessons for general practice
    Tom Fahey
    Tayside Centre for General Practice, University of Dundee, Kirsty Semple Way, Dundee DD2 4AD
    Br J Gen Pract 53:471-2. 2003
  42. ncbi Predictors of methadone maintenance treatment utilization in a multisite cohort of illicit opioid users (OPICAN)
    Benedikt Fischer
    Center for Addictions Research of British Columbia, University of Victoria, British Columbia, Canada
    J Subst Abuse Treat 34:340-6. 2008
    ..This study highlights potential factors relevant for improved MMT uptake and illustrates possible reductions of drug use related to MMT...
  43. ncbi Effect of morphine on the neuropathogenesis of SIVmac infection in Indian Rhesus Macaques
    Joanne K Marcario
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Mail Stop 3043, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Neuroimmune Pharmacol 3:12-25. 2008
    ..This difference may have been associated with the immunosuppressive effect of the drug in inhibiting CMI responses...
  44. pmc Predictors of retention in community-based methadone maintenance treatment program in Pearl River Delta, China
    Fang Yang
    Institute for AIDS Prevention and Control, Center for Disease Control and Prevention of Guangdong Province, 176 Xin gang road west, Guangzhou, 510300, China
    Harm Reduct J 10:3. 2013
    ..The aims were to identify predictors of treatment retention in methadone maintenance treatment (MMT) clinics in Pearl River Delta, China...
  45. pmc Morphine potentiates neuropathogenesis of SIV infection in rhesus macaques
    Sirosh M Bokhari
    Department of Medicine, Division of Molecular Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neuroimmune Pharmacol 6:626-39. 2011
    ..Similarly, there was a trend toward increased virus build-up in the brains of M+V animals compared with controls. A novel finding of this study was the increased influx of infected monocyte/macrophages in the brains of M+V animals...
  46. ncbi Patterns of abuse among unintentional pharmaceutical overdose fatalities
    Aron J Hall
    Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    JAMA 300:2613-20. 2008
    ..The effect of this pharmacoepidemic has been most pronounced in rural states, including West Virginia, which experienced the nation's largest increase in drug overdose mortality rates during 1999-2004...
  47. ncbi Chronic morphine accelerates the progression of lipopolysaccharide-induced sepsis to septic shock
    Frank M Ocasio
    Department of Biology, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA
    J Neuroimmunol 149:90-100. 2004
    ..Our study presents both the molecular and cellular mechanisms underlying the potentiated LPS-induced inflammation and accelerated progression to septic shock seen with chronic morphine exposure...
  48. ncbi Does retention matter? Treatment duration and improvement in drug use
    Zhiwei Zhang
    NORC at the University of Chicago, Washington, DC 20036, USA
    Addiction 98:673-84. 2003
    ..This study examines whether there is a minimum threshold, continuous or non-linear relationship between the duration of addiction treatment and improvements in drug use...
  49. ncbi Drug addiction
    Jordi Camí
    Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Barcelona, Spain
    N Engl J Med 349:975-86. 2003
  50. pmc Morphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons
    Rajarshi Sengupta
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    J Neurosci 29:2534-44. 2009
    ..By this mechanism, opiates could reduce the neuroprotective functions of CXCR4 and exacerbate neuropathology in opiate abusers who are affected by neuroinflammatory/infectious disorders, including neuroAIDS...
  51. ncbi The prevalence of mental and physical health disorders among older methadone patients
    Daniel Rosen
    University of Pittsburgh School of Social Work, Pittsburgh, PA 15260, USA
    Am J Geriatr Psychiatry 16:488-97. 2008
    ..The goal of this study was to assess the physical and mental health status of older methadone patients...
  52. pmc Orexin mediates the expression of precipitated morphine withdrawal and concurrent activation of the nucleus accumbens shell
    Ruth Sharf
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 64:175-83. 2008
    ..Although a role for orexin has been shown in reward and dependence, the molecular and neural mechanisms are unclear. We investigated the mechanism and neuroanatomic basis of orexin's role in morphine withdrawal...
  53. ncbi Morphine alters the structure of neurons in the nucleus accumbens and neocortex of rats
    T E Robinson
    Department of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Synapse 33:160-2. 1999
    ..It is suggested that some of the long-term behavioral consequences of repeated exposure to morphine may be due to its ability to reorganize patterns of synaptic connectivity in the forebrain...
  54. ncbi One year outcomes for heroin dependence: findings from the Australian Treatment Outcome Study (ATOS)
    Maree Teesson
    National Drug and Alcohol Research Centre, University of New South Wales, NSW, Australia
    Drug Alcohol Depend 83:174-80. 2006
    ..To determine 1 year outcomes for drug use, criminality, psychopathology and injection-related health problems in those entering treatment for heroin dependence in Australia...
  55. ncbi The characteristics of heroin users entering treatment: findings from the Australian treatment outcome study (ATOS)
    Joanne Ross
    National Drug and Alcohol Research Centre, University of New South Wales, Australia
    Drug Alcohol Rev 24:411-8. 2005
    ..Striking similarities were noted between the non-treatment and treatment groups in length of heroin use career, drug use and treatment histories...
  56. ncbi Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene
    H W Matthes
    UPR 9050 CNRS, ESBS Université Louis Pasteur, Strasbourg, France
    Nature 383:819-23. 1996
    ..We conclude that the mu-opioid-receptor gene product is the molecular target of morphine in vivo and that it is a mandatory component of the opioid system for morphine action...
  57. ncbi Hypoxic/ischaemic brain damage, especially pallidal lesions, in heroin addicts
    S N Andersen
    Institute of Pathology, National Hospital, University of Oslo, Norway
    Forensic Sci Int 102:51-9. 1999
    ..v. heroin addicts might have pallidal infarcts, either as the sole lesion, or combined with other manifestations of hypoxic/ischaemic brain injury. This might give severe mental disturbances in the affected persons...
  58. ncbi Morphine potentiates HIV-1 gp120-induced neuronal apoptosis
    Shuxian Hu
    Division of Infectious Diseases and International Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    J Infect Dis 191:886-9. 2005
    ..These results provide additional insight into the molecular basis whereby opiate abuse could promote HIV-1-associated dementia...
  59. ncbi The GABAB receptor agonist baclofen prevents heroin-induced reinstatement of heroin-seeking behavior in rats
    Maria Sabrina Spano
    Department of Neuroscience, University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy
    Neuropharmacology 52:1555-62. 2007
    ..The present results show that GABA(B) receptor activation may reduce the propensity to resume drug-induced heroin-seeking behavior thus offering a possible approach in maintaining opiate abstinence...
  60. ncbi Neural correlates of the motivational and somatic components of naloxone-precipitated morphine withdrawal
    Francois Frenois
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5541 Interactions Neuronales et Comportements, BP28, Universite Victor Segalen, Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Eur J Neurosci 16:1377-89. 2002
    ....
  61. pmc HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines
    Nazira El-Hage
    Department of Anatomy and Neurobiology, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536 0298, USA
    Glia 53:132-46. 2006
    ..Importantly, increased glial expression of MOR can trigger an opiate-driven amplification/positive feedback of MCP-1 production and inflammation...
  62. ncbi Antiretroviral adherence and HIV treatment outcomes among HIV/HCV co-infected injection drug users: the role of methadone maintenance therapy
    Anita Palepu
    Centre for Health Evaluation and Outcome Sciences, St Paul s Hospital, University of British Columbia, BC, Canada
    Drug Alcohol Depend 84:188-94. 2006
    ..We examined the association of methadone maintenance therapy (MMT) with highly active antiretroviral therapy (HAART) adherence and HIV treatment outcomes among a cohort of HIV/HCV co-infected injection drug users (IDUs)...
  63. ncbi Regulation of RGS proteins by chronic morphine in rat locus coeruleus
    Stephen J Gold
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas TX 75390, USA
    Eur J Neurosci 17:971-80. 2003
    ....
  64. pmc Access to pain treatment as a human right
    Diederik Lohman
    Health and Human Rights Division, Human Rights Watch, 34th Floor, New York, NY 10118, USA
    BMC Med 8:8. 2010
    ..adopted the 1961 Single Convention on Narcotic Drugs which, in addition to addressing the control of illicit narcotics, obligated countries to work towards universal access to the narcotic drugs necessary to alleviate pain and ..
  65. ncbi Chronic morphine exposure and spontaneous withdrawal are associated with modifications of dopamine receptor and neuropeptide gene expression in the rat striatum
    F Georges
    Laboratoire d Histologie Embryologie, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5541, Universite Victor Segalen Bordeaux 2, France
    Eur J Neurosci 11:481-90. 1999
    ..We also show that withdrawal is associated with a down regulation of the postsynaptic D1 and D2 receptors...
  66. ncbi Morphine preconditioning attenuates neutrophil activation in rat models of myocardial infarction
    T L Wang
    Department of Emergency Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Cardiovasc Res 40:557-63. 1998
    ..IS/AAR were definitely lowest for those with morphine PC (24 +/- 7%; p < 0.05). Morphine preconditioning increases NEP activities to attenuate shedding of gp100MEL14 and to ICAM-1 and, thus, provides myocardial protection...
  67. ncbi Dopaminergic mechanisms mediating the incentive to seek cocaine and heroin following long-term withdrawal of IV drug self-administration
    T J de Vries
    Research Institute Neurosciences Vrije Universiteit, Department of Pharmacology, Medical Faculty, Free University, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 143:254-60. 1999
    ..The neurobiological mechanisms underlying the persistence of drug craving in detoxified addicts are still poorly understood...
  68. pmc The effect of methadone maintenance on positive outcomes for opiate injection drug users
    Karen F Corsi
    Department of Psychiatry, University of Colorado Denver School of Medicine, Denver, CO, USA
    J Subst Abuse Treat 37:120-6. 2009
    ..Results from this study show that time in treatment can affect many aspects of the participant's life in a positive way, including reduction of HIV risk...
  69. ncbi The Australian Treatment Outcome Study (ATOS): what have we learnt about treatment for heroin dependence?
    Shane Darke
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia
    Drug Alcohol Rev 26:49-54. 2007
    ..It is argued that treatment for heroin dependence is money well spent, and leads to clear and sustained benefits to both heroin users and society...
  70. ncbi Benefits of retention in methadone maintenance and chronic medical conditions as risk factors for premature death among older heroin addicts
    Ayman Fareed
    Department of Psychiatry, Emory University, School of Medicine, USA
    J Psychiatr Pract 15:227-34. 2009
    ..Identifying risk factors for premature mortality and potential targets for early intervention may reduce rates of premature mortality in older patients maintained on methadone...
  71. pmc Neuropsychological functioning in opiate-dependent subjects receiving and following methadone maintenance treatment
    James Prosser
    Department of Psychiatry and Behavioral Sciences, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, NY 10003, USA
    Drug Alcohol Depend 84:240-7. 2006
    ..This study tests the hypothesis that former heroin users who have detoxified from methadone maintenance therapy and are drug-free have less pronounced cognitive impairment than patients continuing long-term MMT...
  72. ncbi Synergistic neurotoxicity of opioids and human immunodeficiency virus-1 Tat protein in striatal neurons in vitro
    J A Gurwell
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington 40536-0298, USA
    Neuroscience 102:555-63. 2001
    ..These findings demonstrate that acute opioid exposure can exacerbate the neurodegenerative effect of HIV-1 Tat protein in striatal neurons, and infer a means by which opioids may hasten the progression of HIV-associated dementia...
  73. ncbi Potential roles of GABA receptors in morphine self-administration in rats
    Seong Shoon Yoon
    College of Pharmacy, Yeungnam University, Gyeongsan, South Korea
    Neurosci Lett 428:33-7. 2007
    ..These data suggest that activation of both GABA(A) and GABA(B) receptors may be effective in suppressing the reinforcing effects of morphine...
  74. ncbi Heroin self-administration: II. CNS gene expression following withdrawal and cue-induced drug-seeking behavior
    KARA L KUNTZ
    Department of Pharmacology, Pennsylvania State University College of Medicine, R130, 500 University Drive, Hershey, PA 17033, USA
    Pharmacol Biochem Behav 90:349-56. 2008
    ..These latter observations of persistent changes in gene expression following abstinence may reflect molecular correlates of relapse liability...
  75. ncbi Smoking cessation in methadone maintenance
    Steve Shoptaw
    Friends Research Institute, Los Angeles, CA, UCLA, Department of Psychiatry, Los Angeles, CA 90025, USA
    Addiction 97:1317-28; discussion 1325. 2002
    ..To evaluate relapse prevention (relapse prevention) and contingency management (contingency management) for optimizing smoking cessation outcomes using nicotine replacement therapy for methadone-maintained tobacco smokers...
  76. ncbi Benzodiazepine prescription for patients in opioid maintenance treatment in Norway
    Jørgen G Bramness
    Department of Pharmacoepidemiology, Division of Epidemiology, Norwegian Institute of Public Health, PO Box 4404, Nydalen, 0403 Oslo, Norway
    Drug Alcohol Depend 90:203-9. 2007
    ..Previous research has used interview or urine analysis to assess benzodiazepine use. In this study a prescription database was applied...
  77. ncbi Comparison of the reinforcing effects of cocaine and cocaine/heroin combinations under progressive ratio and choice schedules in rats
    Sara Jane Ward
    Neuroscience Program, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Neuropsychopharmacology 30:286-95. 2005
    ..These apparently discrepant results demonstrate that these models are measuring different aspects of drug reinforcement, and suggest that choice procedures in rats provide a useful tool to study speedball self-administration...
  78. ncbi Methadone-nicotine interactions in methadone maintenance treatment patients
    Alexander K Elkader
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Clin Psychopharmacol 29:231-8. 2009
    ..The overall results may help to explain high smoking rates in the MMT population and may account for reports of increased positive effects of methadone when the drugs are taken together...
  79. pmc From mouse to man: the 5-HT3 receptor modulates physical dependence on opioid narcotics
    Larry F Chu
    Department of Anesthesiology, Stanford University, Palo Alto, California, USA
    Pharmacogenet Genomics 19:193-205. 2009
    Addiction to opioid narcotics represents a major public health challenge. Animal models of one component of addiction, physical dependence, show this trait to be highly heritable...
  80. ncbi The impact of benzodiazepine use on methadone maintenance treatment outcomes
    Bruna Brands
    Centre for Addiction and Mental Health, Toronto, Canada
    J Addict Dis 27:37-48. 2008
    ..Only ongoing cocaine use was negatively related to retention. Benzodiazepine use by methadone maintenance treatment patients is associated with a more complex clinical picture and may negatively influence treatment outcomes...
  81. ncbi History and current status of opioid maintenance treatments: blending conference session
    Mary Jeanne Kreek
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University and The Rockefeller University Hospital, New York, NY 10021, USA
    J Subst Abuse Treat 23:93-105. 2002
    ..Future regulatory reform will likely involve the establishment of rules for "office based opioid treatment."..
  82. ncbi Addressing the global tragedy of needless pain: rethinking the United Nations single convention on narcotic drugs
    Allyn L Taylor
    O Neill Institute for National and Global Health Law at Georgetown University Law Center, USA
    J Law Med Ethics 35:556-70, 511. 2007
    ..This article contributes to the discussion of this global health crisis by considering international legal and institutional mechanisms to promote wider accessibility to critical narcotic drugs for pain relief...
  83. pmc Morphine induces the release of CCL5 from astrocytes: potential neuroprotective mechanism against the HIV protein gp120
    Valeriya Avdoshina
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Glia 58:1630-9. 2010
    ..In these cells the neuroprotective effect of opiate agonists was blocked. Our data suggest that morphine may exhibit a neuroprotective activity against M-tropic gp120 through the release of CCL5 from astrocytes...
  84. ncbi Chronic high-dose morphine treatment promotes SH-SY5Y cell apoptosis via c-Jun N-terminal kinase-mediated activation of mitochondria-dependent pathway
    Xin Lin
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
    FEBS J 276:2022-36. 2009
    ..Thus, the present study clearly shows that morphine-induced apoptosis in SH-SY5Y cells involves JNK-dependent activation of the mitochondrial death pathway, and that ROS signaling exerts positive feedback regulation of JNK activity...
  85. ncbi Psychobiological responses to drug cues before and after methadone intake in heroin-dependent patients: a pilot study
    Marc Walter
    Psychiatric University Clinics, Division of Substance Use Disorders, University of Basel, Basel, Switzerland
    Eur Neuropsychopharmacol 18:390-3. 2008
    ..Patients displayed blunted cortisol response after post-methadone drug cues (t[15]=3.05, p=0.008) suggesting dissociated craving and cortisol reactivity after methadone intake of possible clinical relevance...
  86. ncbi Pharmacokinetic-pharmacodynamic modeling of opioids
    Jorn Lotsch
    Pharmazentrum Frankfurt, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University Hospital, Frankfurt, Germany
    J Pain Symptom Manage 29:S90-103. 2005
    ..It may provide a rational basis for the selection of opioids in clinical circumstances. PK/PD modeling of opioids may also be employed for the design and the interpretation of experiments addressing clinical effects of opioids...
  87. ncbi Effects of morphine on gene expression in the rat amygdala
    J M Rodriguez Parkitna
    Department of Molecular Neuropharmacology, Institute of Pharmacology PAN, Cracow, Poland
    J Neurochem 91:38-48. 2004
    ..Additionally, acute as well as chronic intraperitoneal morphine administration changed the abundance of PKC gamma, gamma1 subunit of GABAA and hsp70 genes...
  88. ncbi Micro-opioid receptor alkylation in the ventral pallidum and ventral tegmental area, but not in the nucleus accumbens, attenuates the effects of heroin on cocaine self-administration in rats
    Thomas J Martin
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neuropsychopharmacology 33:1171-8. 2008
    ..These data suggest that heroin may attenuate feedback inhibition from the NAc to the VP and VTA when co-self-administered with cocaine, resulting in a positive modulation of the effects of cocaine...
  89. ncbi Role of oxidative stress and heme oxygenase activity in morphine-induced glomerular epithelial cell growth
    Jaimita Patel
    Immunology and Inflammation Center for Excellence, North Shore Long Island Jewish Research Institute, New Hyde Park, NY 11040, USA
    Am J Physiol Renal Physiol 285:F861-9. 2003
    ..Morphine, de novo, had bimodal effects on HO activity: lower concentrations increased and higher concentrations decreased HO activity. It appears that HO activity may be modifying morphine-induced GEC growth...
  90. pmc Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death
    Masami Suzuki
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0613, USA
    Mol Neurodegener 6:78. 2011
    ..Time-lapse digital images were continuously recorded at 20 min intervals for up to 72 h using computer-aided microscopy to track the same cells repeatedly...
  91. ncbi Preferential vulnerability of astroglia and glial precursors to combined opioid and HIV-1 Tat exposure in vitro
    Valeriya K Khurdayan
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, KY, USA
    Eur J Neurosci 19:3171-82. 2004
    ..Our results imply that opiates can enhance the cytotoxicity of HIV-1 Tat through direct actions on glial precursors and/or astroglia, suggesting novel cellular targets for HIV-opiate interactions...
  92. ncbi Rulings in Argentinean and Colombian courts decriminalize possession of small amounts of narcotics
    David Cozac
    Canadian HIV AIDS Legal Network
    HIV AIDS Policy Law Rev 14:54-5. 2009
    ..In Colombia, the Supreme Court of Justice ruled on 8 July 2009 that the possession of illegal drugs for personal use was not a criminal offence...
  93. ncbi Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action
    Jorn Lotsch
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Clin Pharmacol Ther 79:72-89. 2006
    ....
  94. ncbi Labor analgesia and breast feeding: avoid parenteral narcotics and provide lactation support
    William Camann
    Int J Obstet Anesth 16:199-201. 2007
  95. ncbi Expression of morphine-conditioned place preference is more vulnerable than naloxone-conditioned place aversion to disruption by nociceptin in mice
    Kazuto Sakoori
    Molecular Neuropathology Group, RIKEN Brain Science Institute, Wakoshi, Saitama 351 0198, Japan
    Neurosci Lett 443:108-12. 2008
    ..These results suggest that nociceptin more potently blocks the ability of reward-associated cues than aversion-associated cues to influence behavioral biases...
  96. ncbi Erectile dysfunction in male heroin users, receiving methadone and buprenorphine maintenance treatment
    Gianluca Quaglio
    Medical Service for Addictive Disorders, Department of Internal Medicine, University of Verona, Italy
    Drug Alcohol Depend 94:12-8. 2008
    ..Both psychological and social factors were associated with ED which is an important problem for many males in methadone and buprenorphine treatment...
  97. ncbi Pattern of regional cerebral blood-flow changes induced by acute heroin administration--a perfusion MRI study
    S Guyer
    Psychiatric Neuroimaging Group, Department of Psychiatry, University Hospital, Bern, Switzerland
    J Neuroradiol 34:322-9. 2007
    ..We examined the actions of intravenous diacetylmorphine (heroin), the most widely abused opioid, on regional cerebral blood flow (rCBF), as assessed by perfusion-weighted MR imaging (PWI) in a double-blind and placebo-controlled setting...
  98. ncbi Heroin reduces startle and cortisol response in opioid-maintained heroin-dependent patients
    Marc Walter
    Psychiatric Hospital, University of Basel, Switzerland
    Addict Biol 16:145-51. 2011
    ..Acute DAM administration may suppress cortisol levels, and DAM maintenance treatment may represent an effective alternative to methadone in stress-sensitive, heroin-dependent patients...
  99. ncbi Lipopolysaccharide-induced pro-inflammatory cytokines in the brain of rats in the morphine-tolerant state
    Linda Staikos
    Institute of Neuroimmune Pharmacology, Seton Hall University, 400 South Orange Ave, South Orange, NJ 07079, USA
    J Neuroimmune Pharmacol 3:236-40. 2008
    ..IL-1beta mRNA increased 2 h post-LPS treatment, whereas IL-6 decreased. At 16 h, TNF-alpha expression mRNA increased. These data suggest that the inflammatory response in the brain is heightened during morphine tolerance...
  100. ncbi Involvement of the ventral tegmental area (VTA) in morphine-induced memory retention in morphine-sensitized rats
    Mohammad Reza Zarrindast
    Department of Pharmacology and Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, P O Box 13145 784, Tehran, Iran
    Behav Brain Res 163:100-6. 2005
    ..c.) or sulpiride (25, 50 and 100mg/kg, s.c.), during the sensitization. The results suggest that VTA has an important role in morphine-induced amnesia and morphine sensitization affects this process through opioid and dopamine receptors...
  101. pmc Morphine induces AMPA receptor internalization in primary hippocampal neurons via calcineurin-dependent dephosphorylation of GluR1 subunits
    Angel Y F Kam
    Department of Pharmacology and Basic Research Center on Molecular and Cell Biology of Drug Addiction, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 30:15304-16. 2010
    ..Together, these findings reveal a novel molecular mechanism for opioid-induced neuronal adaptation and/or synaptic impairment...

Research Grants62

  1. Therapeutic Approaches for Extinction of Conditioned Drug Reward
    Gary B Kaplan; Fiscal Year: 2013
    ..In military and VA settings, soldiers and Veterans face acute or chronic pain that is managed by opiate narcotics and misuse of these agents is widely reported...
  2. Vaccines for Sustainable Therapy of Opiate Addiction
    Frank M Orson; Fiscal Year: 2012
    ..Without more effective treatment or prevention approaches for drug abuse, addiction to narcotics is very likely to accelerate further...
  3. Sleep, Arousal, and Spontaneous Movements in Opioid Exposed Infants
    Marie J Hayes; Fiscal Year: 2010
    ..Mothers will be grouped based on early (G1, n=20) vs. late entry (G2, n=20) to a Narcotics Treatment Program...
  4. TMS in the Management of Postoperative Pain
    Jeffrey J Borckardt; Fiscal Year: 2010
    ..Despite profound advances in neuroscience, opiate narcotics are heavily relied upon for postoperative pain control...
  5. Wearable Technology for Assessment of Personal Exposure to Volatile Organic Compo
    Stephen L Coy; Fiscal Year: 2011
    ..types of explosives and of chemical warfare agents), medical uses (breath analysis), and law enforcement uses (narcotics)...
  6. Treatment of SLE with ajulemic acid, a non-psychoactive cannabinoid derivative
    Meggan Mackay; Fiscal Year: 2013
    ..gastrointestinal bleeding and kidney toxicity in the case of NSAIDS, somnolence, constipation and nausea for narcotics and osteoporosis, osteonecrosis, diabetes, cataracts and atherosclerosis for corticosteroids...
  7. Transcranial Direct Current Stimulation in the Management of Post-operative Pain
    Jeffrey J Borckardt; Fiscal Year: 2013
    ..Despite the profound advances in neuroscience over the past 20 years, we still largely use opiate narcotics, much as was done in the Civil War...
  8. Innovative Curriculum for Mid-Career Training in Palliative Care
    FRANK DOUGLAS FERRIS MD; Fiscal Year: 2013
    ..consumption in each country where the intervention is targeted as measured and reported by the International Narcotics Control Board (INCB)...
  9. ChemR23 agonists for pain and inflammation
    Miguel Garcia-Guzman; Fiscal Year: 2011
    ..Current treatments are insufficient to address the challenge of acute and chronic pain. Narcotics pose a problem of addiction and safety risk while other types of analgesics (e.g...
  10. Opioids and the Aging Brain: Dementia, Cognitive Decline and Neuropathology
    Sascha Dublin; Fiscal Year: 2013
    ..function: studies have found Alzheimer's Disease-like changes in the brains of young drug abusers who use narcotics, and opioids cause programmed cell death in microglia (brain immune cells) and neurons...
  11. NCMHD Southeastern Exploratory Sickle Cell Center of Excellence
    Abdullah Kutlar; Fiscal Year: 2013
    ..F inducing drug, hydroxyurea, ii) identifying genetic variations underlying the frequency of pain, response to narcotics, and thus addressing the important issue of biologic/genetic bases of pain and its under treatment leading to ..
  12. Point-of-care Testing for Illicit Drugs and Alcohol Intoxication in an Emergency
    Marcel Benz; Fiscal Year: 2011
    ..analysis system based on a chemical sensor array that is specialized for the detection of ethanol and narcotics. The core technology is a miniature gas chromatograph that will utilize a dual detector system based on a MEMS ..
  13. Deep brain stimulation of the ventral anterior limb of the internal capsule for m
    Andre Machado; Fiscal Year: 2009
    ..neuropathic pain, such as spinal cord stimulation, thalamic deep brain stimulation or intrathecal infusion of narcotics, are aimed at producing analgesia and are known to have limited efficacy...
  14. A Phase 3, Double-Blind Efficacy, Safety and Dose-Response Study of Lofexidine (S
    Charles W Gorodetzky; Fiscal Year: 2013
    ..With a growing trend of millions of Americans becoming dependent on prescription and other short-acting opioid narcotics, there is an unmet medical need for new detoxification treatments...
  15. Dynorphins and Kappa Opioid Receptors in the Stress Response
    Charles Chavkin; Fiscal Year: 2013
    ..Potential of Kappa Opioids in Pain and Addiction" and service on the executive committees of the International Narcotics Research Conference (INRC)...
  16. Point-of-care Testing for Illicit Drugs and Alcohol Intoxication in an Emergency
    Marcel Benz; Fiscal Year: 2013
    ..portable, point-of-contact analytical instrument;a screening tool for the simultaneous detection of alcohol and narcotics. The core technology is a miniature gas chromatograph (Mini-GC) that uses a multi-detector system to analyze the ..
  17. Spinal Noradrenergic Sprouting after Nerve Injury
    James Eisenach; Fiscal Year: 2012
    ..whether from cancer, diabetes, or trauma, can result in chronic pain which is difficult to treat, even with narcotics. These studies in rats and in people with chronic pain will explore new ways to use medicines to help the body&..
  18. Development and Testing of Adolescent Twelve-Step Facilitation
    John F Kelly; Fiscal Year: 2013
    ..Freely available community resources, such as Alcoholics Anonymous (AA) and Narcotics Anonymous (NA) have been shown to be helpful relapse prevention and recovery resources and also appear cost-..
  19. Annual Meeting of College on Problems of Drug Dependence
    Martin W Adler; Fiscal Year: 2013
    ..In 2011, the CPDD meeting will be held in conjunction with the International Narcotics Research Conference (INRC)...
  20. 41st-45th Annual International Narcotics Research Conferences
    Lakshmi A Devi; Fiscal Year: 2013
    This grant application is to request support for the 41st-45th annual International Narcotics Research Conferences (INRC)...
  21. EFFICACY AND SAFETY OF NARCOTICS FOR PEDIATRIC SEDATION
    Paul Moore; Fiscal Year: 1990
    ..The use of multiple behavioral assessment scales and multiple physiologic measures will permit a simultaneous evaluation of the sensitivity and reliability available methodologies for determining clinical safety and efficacy...
  22. Peripheral Nerve Blocks with Multimodal Analgesics
    Brian Williams; Fiscal Year: 2009
    ..The most common method to treat pain after surgery is with opioid analgesics (narcotics), which can both have many side effects and also be addictive...
  23. AROMATIC AMINE LOCAL ANESTHETICS AND MEMBRANES
    Issaku Ueda; Fiscal Year: 1990
    ..Nevertheless, atypical local anesthetics, such as alcohols, tranquilizers, antihistaminics, barbiturates, narcotics, general anesthetics, etc., also block nerve conduction...
  24. NONPHARMACOLOGIC ANALGESIA FOR INVASIVE PROCEDURES
    Elvira Lang; Fiscal Year: 2005
    ..Distress management for these procedures, in general, relies on "intravenous conscious sedation" with narcotics and sedatives...
  25. Enabling Electronic Prescribing and Enhanced Management of Controlled Medications
    Grant Carrow; Fiscal Year: 2009
    ..Expansion of e-prescribing to cover federally controlled substances (e.g., narcotics, stimulants, sedatives) will also increase needed access to and reduce risks of dangerous pharmaceuticals, ..
  26. Sedation and Psychopharmacology in Critical care
    Marjolein de Wit; Fiscal Year: 2007
    ..prevalence of psychiatric complications, and (3) to compute the pharmacokinetics of commonly used sedatives and narcotics. These aims will be achieved by enrolling critically ill patients in a prospective randomized trial comparing ..
  27. Race in Physician Decision to Prescribe Opioid Analgesia
    JOSHUA SARVER; Fiscal Year: 2002
    ..2) whether providing information on patients? socioeconomic status, role impairment, and likelihood that narcotics might be misused mitigates the effect of race on physicians? decisions to prescribe analgesics; and 3) whether ..
  28. 38th Annual International Narcotics Research Conference
    Jean Bidlack; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): Support is requested for the 38th annual meeting of the International Narcotics Research Conference (INRC) to be held in Berlin, Germany from July 8-13, 2007...
  29. Nasal Contour Pack for Epistaxis
    PAUL BUREK; Fiscal Year: 2002
    ..Gauze packing decreases blood oxygen levels and is extremely painful, requiring administration of narcotics. Nasal balloons resist conformation to the intricacies of the nasal cavity...
  30. The Dynamics of Methamphetamine Markets: A Systematic Approach to the Process
    HENRY BROWNSTEIN; Fiscal Year: 2009
    ..g., arrestees, treatment clients), community organizers and providers, local narcotics police, and local public health officials...
  31. Effect of Complementary and Alternative Medicine on Pain Among Inpatients
    Jeffery A Dusek; Fiscal Year: 2013
    ..Findings may also drive future research on the cost effectiveness of these therapies for pain management, as well as impact on patient outcomes such as length of stay and use of narcotics.
  32. 12-Step Recovery and HIV Risk Among Gay and Bisexual Men
    Thomas Lyons; Fiscal Year: 2005
    ..study explores the effect of involvement of gay and bisexual men in community-based Alcoholics Anonymous, Narcotics Anonymous and Crystal Meth Anonymous on high HIV risk sexual behavior...
  33. Nasal Contour Pack for Epistaxis
    KENNETH WEIL; Fiscal Year: 2004
    ..Gauze packing decreases blood oxygen levels and is extremely painful, requiring administration of narcotics. Nasal balloons resist conformation to the intricacies of the nasal cavity...
  34. Structural Studies of the Glycine Receptor
    Michael Cascio; Fiscal Year: 2003
    ..Since this receptor family is targeted by anesthetics, alcohols, inhaled solvents and other narcotics, these structural determinations will impact on our understanding of the basic mechanisms underlying ion channel ..
  35. SYNTHESIS AND DISTRIBUTION OF OPIOID & RELATED PEPTIDES
    Richard Houghten; Fiscal Year: 2000
    For nearly two decades, the National Institute on Drug Abuse and it's predecessor, Center for Studies of Narcotics and Drug Abuse, NIMH, has provided the scientific community working on problems of drug abuse with authentic, standardized ..
  36. BIOTRANSFORMATION OF ACETYLMETHADOL AND RELATED DRUGS
    Michael Franklin; Fiscal Year: 1980
    ..complexes inhibits the metabolism of the drugs themselves, as well as the metabolism of other drugs, especially narcotics, where the main route of biotransformation is oxidative metabolism...
  37. Drugs to Elevate Enkephalin as Novel Opiate Analgesics
    Terry Reisine; Fiscal Year: 2004
    ..of enkephalin in the nervous system could be a new treatment for pain with major advantages over presently used narcotics. Enkephalins are produced by a series of proteolytic events that cleave the large protein precursor, ..
  38. Neonatal Morphine: Long-term Cerebrovascular Effects
    Christine Gleason; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Prolonged use of narcotics such as morphine to relieve stress in critically ill preterm infants is an important health care issue-- in part because of the important influence of the postnatal ..
  39. PINEAL OPIOID RECEPTORS & ANALGESIC ACTION OF MELATONIN
    Manuchair Ebadi; Fiscal Year: 2002
    ..receptor agonist-antagonism, it is doubtful that physician simply could potentiate the analgesic efficacy of narcotics such as morphine by co-administering melatonin...
  40. COMPARISON OF SPINAL AND SUPRASPINAL PAIN THRESHOLDS
    GEORGE BORSZCZ; Fiscal Year: 1993
    ..These treatments include systemic administration of the narcotics morphine and fentanyl, and of the benzodiazepine diazepam...
  41. TIME SERIES ANALYSIS OF DRUG USE AND CRIME IN NYC
    Hope Corman; Fiscal Year: 1993
    ..police policies such as: the total number of officers, the number of officers specifically assigned to the Narcotics Division and other special units, overall arrest rates, the allocation of arrests between drug and non-drug ..
  42. CALCIUM CURRENT DEPRESSION BY VOLATILE ANESTHETICS
    Carl Lynch; Fiscal Year: 1999
    ..Since narcotics and alpha2-adrenoceptors also depress Ca currents, the interaction of these analgesic drugs with volatile ..
  43. INFLUENCE OF TRIPLICATE POLICY ON NARCOTIC UTILIZATION
    Linda Simoni Wastila; Fiscal Year: 1992
    Due to their potential to be abused by patients and non-patients alike, narcotics are extensively regulated by state and federal laws and regulations...
  44. AN ABEF SYNTHON FOR NORDITERPENOID ALKALOIDS
    David Lewis; Fiscal Year: 2001
    ..of contemporary maintenance programs which remain centered around the controlled administration of substitute narcotics such as methadone...
  45. QUANTITATIVE ANALYSIS OF A METHOD DEVELOPMENT FOR CANN
    C Cook; Fiscal Year: 2000
    For nearly two decades, the National Institute on Drug Abuse and it's predecessor, Center for Studies of Narcotics and Drug Abuse, NIMH, has provided the scientific community working on problems of drug abuse with authentic, standardized ..
  46. SECOND GENESIS RESEARCH DEMONSTRATION
    Samuel Karson; Fiscal Year: 1993
    ..The principles of Alcoholics Anonymous and Narcotics Anonymous provide a foundation for the program. The milieu is dynamic, with a moderated level of confrontation...
  47. ENHANCED METHADONE MAINTENANCE PROG FOR AIDS CONTAINMENT
    M Anglin; Fiscal Year: 1993
    ..Three subsamples of narcotics IVDU shown by recent local seroprevalence surveys to be most at risk for transmission of, or infection by, HIV ..
  48. A Dynamic Multilevel Analysis of Substance Use and HIV
    Katharine Poundstone; Fiscal Year: 2004
    ..g., community policing, targeted narcotics crackdowns) increases the risk of HIV transmission; 3) Informal social regulation (e.g...
  49. DEVELOPMENT OF TRANSNASAL KETAMINE FOR BREAKTHROUGH PAIN
    FRED MERMELESTEIN; Fiscal Year: 2000
    ..controlled by the variety of analgesics currently on the market, the most common of which are immediate-release narcotics. These agents are typically slow in onset of action and cause side effects including nausea, vomiting, ..
  50. EPIDEMIOLOGY OF HIV1 AMONG OPIATE USERS IN N THAILAND
    David Celentano; Fiscal Year: 2001
    ..users in northern Thailand, and to determine whether methadone maintenance is associated with reduced relapse to narcotics use as compared to methadone-assisted detoxification on an outpatient basis...
  51. Prescription Drug Abuse in Adolescents and Young Adults
    Linda Simoni Wastila; Fiscal Year: 2005
    ..prescription drugs among individuals age 12-25 has been increasing, especially new use of prescription narcotics. To date, few studies have explicitly examined adolescents' and young adults' non-medical use and abuse of ..
  52. South Carolina Opioid Safety Initiative (SCOSI)
    CHARLES LEE contact BENNETT; Fiscal Year: 2011
    ..a data-base effort designed to identify specific providers who have large panels of patients who receive opioid narcotics. Based on our preliminary data and discussions with opioid experts, we expect that oncology will be a central ..
  53. NEUROCHEMISTRY OF NOCICEPTION
    Patrick Mantyh; Fiscal Year: 2002
    ..syndromes presents a tremendous challenge to the medical field as current pain management approaches with narcotics, such as morphine, carry adverse side effects such as sedation, constipation, tolerance and addiction...
  54. PHARMACOLOGY OF NARCOTICS & NARCOTIC ANTAGONISTS
    JAMES MC KEARNEY; Fiscal Year: 1991
    ..In addition to morphine and naloxone, other drugs with differing affinities for the mu- and kappa-opioid receptor subtypes will be studied...
  55. Pathways ot long-term abstinence:Self-help processes
    Alexandre Laudet; Fiscal Year: 2006
    ..of SH affiliation among other groups of individuals, especially illicit polysubstance users who may attend Narcotics Anonymous rather than or in addition to AA...
  56. A High-Resolution Differential Mobility Analyzer to Study Biomolecules
    CHAMINDA GAMAGE; Fiscal Year: 2009
    ..It is also used for the detection of airborne chemical agents such as explosives, chemical warfare agents, narcotics and toxic industrial chemicals and for the study of aerosol particles...
  57. LONG-ACTING NARCOTIC METABOLISM AND DRUG INTERACTIONS
    Mary Kreek; Fiscal Year: 1980
    ..goals of this ongoing research project are to study the metabolism, excretion and persistence of long-acting narcotics, using methadone as a prototypic compound, in man, primarily in tolerant humans maintained on methadone, and in ..
  58. RESTRUCTURING, DESTRUCTURING AND ANONYMOUS ORGANIZATIONS
    JAMES AWBREY; Fiscal Year: 2000
    ..e. Narcotics Anonymous (NA) and Alcoholics Anonymous (AA)...
  59. Substance Abuse Treatment Support Group Matching
    Randolph Atkins; Fiscal Year: 2004
    ..however, many clients may experience problems with spiritually based groups, such as Alcoholics Anonymous and Narcotics Anonymous, which are predominant in the treatment industry...
  60. Opioid Analgesia in Awake Mice
    Peggy Mason; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Long after their first use by humans, narcotics remain the most widely used and effective treatment for clinical pain despite their disadvantages: numerous side effects, the development of tolerance, ..
  61. AMERICAN WOMEN AND SUBSTANCE ABUSE 1865-1980
    DAVID MUSTO; Fiscal Year: 2001
    The proposed project builds on Dr. Musto's perspective on U.S. narcotics policy during the 19th and 20th Centuries, gained over the course of his long career studying American drug use...
  62. BIOBEHAVIORAL STUDIES OF NARCOTICS ABUSE
    Jack Mendelson; Fiscal Year: 2007
    ....