intravenous anesthetics

Summary

Summary: Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)

Top Publications

  1. ncbi Intravenous anesthetics differentially modulate ligand-gated ion channels
    P Flood
    Department of Anesthesiology, Columbia University, New York, New York 10032, USA
    Anesthesiology 92:1418-25. 2000
  2. ncbi Dose-dependent effects of propofol on the central processing of thermal pain
    Robert K Hofbauer
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Anesthesiology 100:386-94. 2004
  3. ncbi Facilitation of serotonergic activity and amnesia in rats caused by intravenous anesthetics
    Kazunori Semba
    Department of Anesthesiology and Resuscitology, Ehime University School of Medicine, Japan
    Anesthesiology 102:616-23. 2005
  4. ncbi Sleep deprivation potentiates the onset and duration of loss of righting reflex induced by propofol and isoflurane
    Avery Tung
    Department of Anesthesia and Critical Care, University of Chicago, Illinois, USA
    Anesthesiology 97:906-11. 2002
  5. pmc The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: a comparative study
    M Pistis
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee
    Br J Pharmacol 122:1707-19. 1997
  6. pmc The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid
    D Belelli
    Neurosciences Institute, Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, Dundee University, Dundee, DD1 9SY, United Kingdom
    Proc Natl Acad Sci U S A 94:11031-6. 1997
  7. ncbi The effects of general anaesthetics on carbachol-evoked gamma oscillations in the rat hippocampus in vitro
    R Dickinson
    Biophysics Group, Imperial College of Science, Technology and Medicine, Blackett Laboratory, Prince Consort Road, London SW7 2BW, UK
    Neuropharmacology 44:864-72. 2003
  8. ncbi Inhalational or intravenous anesthetics for craniotomies? Pro inhalational
    Kristin Engelhard
    Klinik fur Anasthesiologie, Johannes Gutenberg Universitat, Mainz, Germany
    Curr Opin Anaesthesiol 19:504-8. 2006
  9. ncbi A comparison of pharmacokinetic/pharmacodynamic versus mass-balance measurement of brain concentrations of intravenous anesthetics in sheep
    Logan J Voss
    Department of Anaesthesia and Intensive Care, University of Adelaide and Royal Adelaide Hospital, North Terrace, Adelaide University, Adelaide, South Australia, Australia
    Anesth Analg 104:1440-6, table of contents. 2007
  10. ncbi Effects of halothane and propofol on excitatory and inhibitory synaptic transmission in rat cortical neurons
    Akira Kitamura
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    J Pharmacol Exp Ther 304:162-71. 2003

Detail Information

Publications222 found, 100 shown here

  1. ncbi Intravenous anesthetics differentially modulate ligand-gated ion channels
    P Flood
    Department of Anesthesiology, Columbia University, New York, New York 10032, USA
    Anesthesiology 92:1418-25. 2000
    ..nAChRs) are potently inhibited by volatile anesthetics, but it is not known whether they are affected by intravenous anesthetics. Ketamine potentiates gamma-aminobutyric acid type A (GABAA) receptors at high concentrations, but it is ..
  2. ncbi Dose-dependent effects of propofol on the central processing of thermal pain
    Robert K Hofbauer
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Anesthesiology 100:386-94. 2004
    ..Anatomic and physiologic data show that multiple regions of the forebrain are activated by pain. However, the effect of anesthetic level on nociceptive input to these regions is not well understood...
  3. ncbi Facilitation of serotonergic activity and amnesia in rats caused by intravenous anesthetics
    Kazunori Semba
    Department of Anesthesiology and Resuscitology, Ehime University School of Medicine, Japan
    Anesthesiology 102:616-23. 2005
    ..Because an increase in central serotonergic activity impairs learning and memory, the authors examined the relation between changes in the serotonergic activity caused by intravenous anesthetics and memory.
  4. ncbi Sleep deprivation potentiates the onset and duration of loss of righting reflex induced by propofol and isoflurane
    Avery Tung
    Department of Anesthesia and Critical Care, University of Chicago, Illinois, USA
    Anesthesiology 97:906-11. 2002
    ..Changes in the propensity to sleep may then modify the response to anesthetic agents. The authors tested the hypothesis that sleep-deprived rats would require less anesthetic than rested rats to achieve a similar loss of responsiveness...
  5. pmc The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: a comparative study
    M Pistis
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee
    Br J Pharmacol 122:1707-19. 1997
    ..However, the presence on glycine receptors of lower affinity modulatory binding sites for pentobarbitone, propofol and trichloroethanol may aid in the identification of the molecular determinants of the CNS actions of these anaesthetics...
  6. pmc The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid
    D Belelli
    Neurosciences Institute, Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, Dundee University, Dundee, DD1 9SY, United Kingdom
    Proc Natl Acad Sci U S A 94:11031-6. 1997
    ..Together with the lack of effect of intracellular etomidate, the data argue against a unitary, lipid-based theory of anesthesia...
  7. ncbi The effects of general anaesthetics on carbachol-evoked gamma oscillations in the rat hippocampus in vitro
    R Dickinson
    Biophysics Group, Imperial College of Science, Technology and Medicine, Blackett Laboratory, Prince Consort Road, London SW7 2BW, UK
    Neuropharmacology 44:864-72. 2003
    ....
  8. ncbi Inhalational or intravenous anesthetics for craniotomies? Pro inhalational
    Kristin Engelhard
    Klinik fur Anasthesiologie, Johannes Gutenberg Universitat, Mainz, Germany
    Curr Opin Anaesthesiol 19:504-8. 2006
    ....
  9. ncbi A comparison of pharmacokinetic/pharmacodynamic versus mass-balance measurement of brain concentrations of intravenous anesthetics in sheep
    Logan J Voss
    Department of Anaesthesia and Intensive Care, University of Adelaide and Royal Adelaide Hospital, North Terrace, Adelaide University, Adelaide, South Australia, Australia
    Anesth Analg 104:1440-6, table of contents. 2007
    ....
  10. ncbi Effects of halothane and propofol on excitatory and inhibitory synaptic transmission in rat cortical neurons
    Akira Kitamura
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    J Pharmacol Exp Ther 304:162-71. 2003
    ..The additional calcium-dependent inhibition of mIPSC and mEPSC frequency by halothane (but not propofol) suggests a more general mechanism by this anesthetic on presynaptic transmitter release...
  11. ncbi Endocrine stress response and inflammatory activation during CABG surgery. A randomized trial comparing remifentanil infusion to intermittent fentanyl
    M Winterhalter
    Hannover Medical School, Department of Anaesthesiology, Hannover, Germany
    Eur J Anaesthesiol 25:326-35. 2008
    ....
  12. ncbi Effects of intravenous anesthetics on renal ischemia/reperfusion injury
    Husamettin Yuzer
    Department of General Surgery, Faculty of Medicine, Kahramanmaras Sutcuimam University, Kahramanmaras, Turkey
    Ren Fail 31:290-6. 2009
    ..Aim. The purpose of this study was to investigate and compare the efficiency of ketamine, thiopental, propofol, etomidate, and intralipid in reducing the injury induced by free radicals in a rat model of renal I/R...
  13. ncbi Propofol anesthesia and cerebral blood flow changes elicited by vibrotactile stimulation: a positron emission tomography study
    V Bonhomme
    Department of Anesthesia, McGill University, Montreal, Quebec H3A 1A2, Canada
    J Neurophysiol 85:1299-308. 2001
    ..We conclude that propofol interferes with the processing of vibrotactile information first at the level of the cortex before attenuating its transfer through the thalamus...
  14. ncbi Propofol directly depresses lumbar dorsal horn neuronal responses to noxious stimulation in goats
    J F Antognini
    Department of Anesthesiology and Pain Management, University of California, Davis 95616, USA
    Can J Anaesth 47:273-9. 2000
    ..We recorded the response of lumbar dorsal horn neurons during differential delivery of propofol to the brain and torso of goats...
  15. ncbi Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane
    M D Krasowski
    Department of Committee on Neurobiology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Pharmacol 53:530-8. 1998
    ..In most cases, these mutations had little or no effect on the actions of these intravenous anesthetics. However, a point mutation in the beta1 subunit (M286W) abolished potentiation of GABA by propofol but ..
  16. ncbi Predictors of hypotension after induction of general anesthesia
    David L Reich
    Department of Anesthesiology, Mount Sinai Medical Center, Box 1010, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Anesth Analg 101:622-8, table of contents. 2005
    ..g., etomidate) should be considered in patients older than 50 yr of age with ASA physical status > or =3. We conclude that it is advisable to avoid propofol induction in patients who present with baseline MAP <70 mm Hg...
  17. ncbi The differential effects of intravenous anesthetics on myofilament Ca2+ sensitivity in pulmonary venous smooth muscle
    Xueqin Ding
    Center for Anesthesiology Research, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Anesth Analg 105:1278-86, table of contents. 2007
    ..In the present study, we investigated the direct effects of ketamine, etomidate, thiopental, and midazolam on pulmonary venous contraction and myofilament Ca2+ sensitivity in permeabilized pulmonary venous smooth muscle (PVSM)...
  18. ncbi Gene regulatory control of myocardial energy metabolism predicts postoperative cardiac function in patients undergoing off-pump coronary artery bypass graft surgery: inhalational versus intravenous anesthetics
    Eliana Lucchinetti
    Institute of Anesthesiology, University Hospital Zurich, and Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Anesthesiology 106:444-57. 2007
    ..This study aimed at identifying myocardial transcriptional phenotypes to predict cardiovascular biomarkers and function in patients undergoing off-pump coronary artery bypass graft surgery...
  19. ncbi Propofol (Diprivan-EDTA) counteracts oxidative injury and deterioration of the arterial oxygen tension during experimental septic shock
    S Basu
    Department of Geriatrics and Clinical Nutrition Research, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Resuscitation 50:341-8. 2001
    ..CONCLUSIONS: Propofol reduced endotoxin-induced free radical mediated and cyclooxygenase catalysed lipid peroxidation significantly. The implication is that propofol counteracts endotoxin-induced deterioration of PaO(2)...
  20. ncbi Intravenous anesthetics are more effective than volatile anesthetics on inhibitory pathways in rat hippocampal CA1
    Takehisa Asahi
    Department of Anesthesiology, University of Toyama, Toyama City, Toyama, Japan
    Anesth Analg 102:772-8. 2006
    ....
  21. ncbi Effects of intravenous anesthetics on interleukin (IL)-6 and IL-10 production by lipopolysaccharide-stimulated mononuclear cells from healthy volunteers
    M Takaono
    Division of Clinical Immunology, Clinical Research Institute, International Medical Center of Japan, Tokyo, Japan
    Acta Anaesthesiol Scand 46:176-9. 2002
    ..The aim of this study was therefore to examine the effects of intravenous anesthetics on the synthesis of interleukin (IL)-6 (a proinflammatory cytokine) and IL-10 (an anti-inflammatory ..
  22. ncbi Memory function during propofol and alfentanil anesthesia: predictive value of individual differences
    Chantal Kerssens
    Department of Anesthesiology, University Hospital Rotterdam, The Netherlands
    Anesthesiology 97:382-9. 2002
    ..The present study investigated memory function during deep sedation (BIS, 60-70). As memory effects are small, the authors studied potential predictors of individual differences in memory performance...
  23. ncbi Effects of intravenous anesthetics on the activity of glutamate transporter EAAT3 expressed in Xenopus oocytes: evidence for protein kinase C involvement
    Jung Yeon Yun
    Department of Anesthesiology and Clinical Research Institute, Seoul National University Hospital College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, South Korea
    Eur J Pharmacol 531:133-9. 2006
    We investigated the effects of the intravenous anesthetics, thiopental, etomidate and ketamine, on the activity of one type of glutamate transporters, EAAT3 (excitatory amino acid transporter type 3)...
  24. ncbi The effects of local and intravenous anesthetics on recombinant rat VR1 vanilloid receptors
    Kazuyoshi Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Japan
    Anesth Analg 96:1656-60, table of contents. 2003
    ..In conclusion, the present data suggest that local but not IV general anesthetics interact with recombinant rat VR1 receptors with the former anesthetics having antagonistic activity...
  25. ncbi Propofol-associated dilation of rat distal coronary arteries is mediated by multiple substances, including endothelium-derived nitric oxide
    K W Park
    Department of Anesthesia and Critical Care, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Anesth Analg 81:1191-6. 1995
    ..This effect is primarily endothelium-dependent and is mediated by multiple substances, including nitric oxide (NO) and a vasodilatory prostanoid. The effect is not mediated by opening of the K(ATP) channels...
  26. ncbi Guidelines for the use of deep sedation and anesthesia for GI endoscopy
    Douglas O Faigel
    Gastrointest Endosc 56:613-7. 2002
  27. ncbi Why we still use intravenous drugs as the basic regimen for neurosurgical anaesthesia
    Pol Hans
    University Department of Anaesthesia and Intensive Care Medicine, CHR de la Citadelle, Liege University Hospital, Liege, Belgium
    Curr Opin Anaesthesiol 19:498-503. 2006
    ..Consequently, new adjustments of anaesthesia should aim at providing brain relaxation, minimal interference with electrophysiological monitoring, rapid recovery, patients' cooperation during surgery and neuroprotection...
  28. ncbi Changes in the effect of propofol in response to altered plasma protein binding during normothermic cardiopulmonary bypass
    E Takizawa
    Department of Anaesthesiology, Saitama Cardiovascular and Pulmonary Centre, 1696 Itai Konan machi Osato gun, Saitama 360 0105, Japan
    Br J Anaesth 96:179-85. 2006
    ..The purpose of this study was to assess changes in the drug effect of propofol in response to altered plasma binding using quantitative EEG measurements...
  29. pmc Should etomidate be the induction agent of choice for rapid sequence intubation in the emergency department?
    A J Oglesby
    Department of Accident and Emergency Medicine, The Royal Infirmary of Edinburgh, Old Dalkeith Road, Edinburgh EH16 4SU, UK
    Emerg Med J 21:655-9. 2004
    ..Important questions regarding the medium to long term effects on adrenocortical function (even after a single dose) remain unanswered...
  30. ncbi Lactic acidosis: an early marker of propofol infusion syndrome?
    Marc Koch
    Intensive Care Med 30:522. 2004
  31. ncbi Plasma propofol concentration and EEG burst suppression ratio during normothermic cardiopulmonary bypass
    K Yoshitani
    Department of Anaesthesiology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    Br J Anaesth 90:122-6. 2003
    ..This topic has not been studied extensively during normothermic CPB. In this study, we related propofol dose to plasma propofol concentration and burst suppression of the EEG during normothermic bypass...
  32. pmc Preoperative anxiety and propofol requirement in conscious sedation for ovum retrieval
    Jeong Yeon Hong
    Department of Anesthesiology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 18:863-8. 2003
    ....
  33. ncbi The syndrome of irreversible acidosis after prolonged propofol infusion
    Monisha A Kumar
    Vascular and Critical Care Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neurocrit Care 3:257-9. 2005
    ..The pathogenesis of this syndrome is thought to be activation of the systemic inflammatory response, which culminates in acidosis and muscle necrosis...
  34. ncbi Response Entropy is not more sensitive than State Entropy in distinguishing the use of esmolol instead of remifentanil in patients undergoing gynaecological laparoscopy
    M Valjus
    Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
    Acta Anaesthesiol Scand 50:32-9. 2006
    ..Our hypothesis was that while keeping SE at a predetermined level, RE would be higher in patients receiving a beta-blocking agent (esmolol) instead of an opioid (remifentanil) during a propofol/nitrous oxide anaesthesia...
  35. ncbi Intravenous anesthetics inhibit capacitative calcium entry in pulmonary venous smooth muscle cells
    Sachiko Shimizu
    Center for Anesthesiology Research, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Anesthesiology 104:791-7. 2006
    ..kinase C, tyrosine kinase (TK), and rho-kinase signaling pathways in regulating CCE; and to investigate the extent and cellular mechanisms by which intravenous anesthetics (thiopental, midazolam, ketamine, and propofol) alter CCE.
  36. ncbi Overestimation of Bispectral Index in sedated intensive care unit patients revealed by administration of muscle relaxant
    Benoit Vivien
    Department of Anesthesiology, Universitaire Pitié Salpêtrière, Paris, France
    Anesthesiology 99:9-17. 2003
    ..This study aimed to investigate the magnitude of the decrease of BIS following administration of muscle relaxant in sedated intensive care unit patients...
  37. ncbi The effects of enflurane, isoflurane, and intravenous anesthetics on rat diaphragmatic function and fatigability
    Kahoru Nishina
    Department of Anaesthesia and Perioperative Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Anesth Analg 96:1674-8, table of contents. 2003
    ..Our results also indicate that large concentrations of enflurane may impair the diaphragmatic function at sites other than excitation-contraction coupling...
  38. ncbi Pretreatment with thiopental for prevention of pain associated with propofol injection
    Anil Agarwal
    Departments of Anesthesia and Biostatistics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Anesth Analg 98:683-6, table of contents. 2004
    ..05). Thiopental 0.5 mg/kg was the most effective treatment. We therefore suggest routine pretreatment with thiopental 0.5 mg/kg along with venous occlusion for 1 min for prevention of pain associated with propofol injection...
  39. ncbi The influence of hemorrhagic shock on propofol: a pharmacokinetic and pharmacodynamic analysis
    Ken B Johnson
    Department of Anesthesiology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Anesthesiology 99:409-20. 2003
    ..To investigate this further, the authors studied the influence of hemorrhagic shock on the pharmacology of propofol in a swine isobaric hemorrhage model...
  40. ncbi Survival of propofol infusion syndrome in a head-injured patient
    Stephanie Mallow Corbett
    Department of Surgery, Division of Trauma Critical Care, University of Vermont College of Medicine Burlington, USA
    Crit Care Med 34:2479-83. 2006
    ..To describe the clinical progression of an adult patient with traumatic brain injury who survived propofol infusion syndrome...
  41. ncbi Differential interaction of anaesthetics and antiepileptic drugs with neuronal Na+ channels, Ca2+ channels, and GABA(A) receptors
    R Lingamaneni
    Department of Anesthesiology, Box 50, LC 203A, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Br J Anaesth 90:199-211. 2003
    ..We compared the interactions of representative agents from each class on their putative targets using well-characterized radioligand binding assays...
  42. ncbi Anesthetic-induced burst suppression EEG activity requires glutamate-mediated excitatory synaptic transmission
    Heath S Lukatch
    Stanford Neuroscience Program and Neuropharmacology Laboratory, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    Cereb Cortex 15:1322-31. 2005
    ..A GABA(A) agonist produced a similar EEG effect to the anesthetics. It appears that anesthetic effects at both glutamate and GABA synapses contribute to EEG patterns seen during anesthesia...
  43. ncbi The mechanisms of the direct action of etomidate on vascular reactivity in rat mesenteric resistance arteries
    Kazuhiro Shirozu
    Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Kyushu University, Fukuoka 812 8582, Japan
    Anesth Analg 108:496-507. 2009
    ..e., cerebral protection) in patients with advanced age or heart disease, and during cardiopulmonary bypass. However, less is known about its action on systemic resistance arteries...
  44. pmc A unitary anesthetic binding site at high resolution
    L Sangeetha Vedula
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:24176-84. 2009
    ..Finally, apoferritin displays both structural and dynamic responses to anesthetic binding, which may mimic changes elicited by anesthetics in physiologic targets like ion channels...
  45. ncbi Incidence of propofol infusion syndrome during noninvasive radiofrequency ablation for atrial flutter or fibrillation
    Grant T Cravens
    Anesthesiology Department, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Anesthesiology 106:1134-8. 2007
    ..Propofol infusion syndrome is first manifest by unexplained metabolic acidosis. Its incidence is unknown...
  46. ncbi Effect of intravenous anesthetics on inward rectifier potassium current in rat and human ventricular myocytes
    C A Carnes
    College of Pharmacy, The Ohio State University, Columbus 43210, USA
    Anesthesiology 87:327-34. 1997
    ..Inhibition of the inward rectifying potassium current (I(K1)) may cause cardiac dysrhythmias by decreasing resting membrane potential or prolonging action potential...
  47. ncbi Functional comparison of anaesthetic agents during myocardial ischaemia-reperfusion using pressure-volume loops
    D T Andrews
    Cardiovascular and Therapeutics Unit, Department of Pharmacology, University of Melbourne, Melbourne, Australia
    Br J Anaesth 103:654-64. 2009
    ..Left ventricular (LV) pressure-volume (PV) loops were used to compare the functional effects that accompany the cardioprotection seen with desflurane, sevoflurane, and propofol in a rabbit preparation of coronary ischaemia-reperfusion (IR)...
  48. ncbi Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery
    G Trapani
    Dipartimento Farmaco Chimico, Facolta di Farmacia, Universita degli Studi di Bari, Via Orabona 4, Bari, 70125, Italy
    Curr Med Chem 7:249-71. 2000
    ....
  49. ncbi Population pharmacokinetics of propofol: a multicenter study
    J Schuttler
    Department of Anesthesiology, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Anesthesiology 92:727-38. 2000
    ..This method requires accurate knowledge of pharmacokinetics, including the effects of age and weight. The authors performed a multicenter population analysis to quantitate the effects of covariates...
  50. ncbi Short-term low-dose propofol anaesthesia associated with severe metabolic acidosis
    A Chukwuemeka
    Division of Cardiovascular Surgery, Department of Surgery, Toronto General Hospital and University of Ontario, Canada
    Anaesth Intensive Care 34:651-5. 2006
    ..This report discusses an unusual adverse effect of propofol anaesthesia and sedation and highlights the need for further investigation to define propofol toxicity...
  51. pmc Effects of propofol on endotoxin-induced acute lung injury in rabbit
    Sang Hyun Kwak
    Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, 8 Hakdong, Dong Gu, Gwangju 501 757, Korea s
    J Korean Med Sci 19:55-61. 2004
    ..In conclusion, propofol attenuated endotoxin-induced acute lung injury in rabbits mainly by inhibiting neutrophil and IL-8 responses, which may play a central role in sepsis-related lung injury...
  52. ncbi Skin impedance correlates to sedation grade, plasma propofol concentrations and bispectral index during a target-controlled infusion of propofol
    Michael Winterhalter
    Department of Anaesthesiology, University of Duesseldorf, Duesseldorf, Germany
    Eur J Anaesthesiol 26:589-96. 2009
    ..The aim of this prospective study was to evaluate electrical skin impedance in comparison with bispectral index values and the Observer's Assessment of Alertness and Sedation (OAAS) scale during propofol infusion...
  53. ncbi Lacticacidosis after short-term infusion of propofol for anaesthesia in a child with osteogenesis imperfecta
    Clemens Kill
    Department of Anaesthesiology and Intensive Care Medicine, Philipps University, Marburg, Germany
    Paediatr Anaesth 13:823-6. 2003
    ..The highest lactate concentration was 9.2 mmol.l-1 at 160 min after discontinuation of propofol. There was no significant increase in body temperature. The boy fully recovered...
  54. ncbi Propofol attenuates ovalbumin-induced smooth muscle contraction of the sensitized rat trachea: inhibition of serotonergic and cholinergic signaling
    Masakazu Yamaguchi
    Department of Anesthesiology, Nagasaki University School of Medicine, Nagasaki, Japan
    Anesth Analg 103:594-600. 2006
    ..These results suggest that the mechanism involved in the attenuation by propofol of OA-induced contraction is inhibition of the actions of 5-HT. Propofol should be a useful anesthetic in patients with immunoglobulin E-related asthma...
  55. ncbi Propofol infusion syndrome: an overview of a perplexing disease
    Vincenzo Fodale
    Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina, Messina, Italy
    Drug Saf 31:293-303. 2008
    ..So, PRIS must be kept in mind as a rare, but highly lethal, complication of propofol use, not necessarily confined to its prolonged use. Furthermore, the safe dosage of propofol may need re-evaluation, and new studies are needed...
  56. ncbi Intravenous lidocaine and ephedrine, but not propofol, suppress fentanyl-induced cough
    Chin Shuang Lin
    Department of Anesthesiology, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei, Taiwan 100
    Can J Anaesth 51:654-9. 2004
    ..The aim of this study was to evaluate the effectiveness of lidocaine, propofol and ephedrine in suppressing fentanyl-induced cough...
  57. ncbi Dose effects of propofol on hemodynamic and cytokine responses to endotoxemia in rats
    Yasuhiro Takemoto
    Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    J Anesth 19:40-4. 2005
    ..The purpose of this study was to elucidate whether these beneficial effects of propofol on hemodynamics and cytokine responses were dose related...
  58. ncbi Anti-inflammatory effects of intravenous anesthetics on endotoxemia
    Takumi Taniguchi
    Department of Emergency and Critical Care Medicine, Graduate School of Medical Science, Kanazawa University, Japan
    Mini Rev Med Chem 5:241-5. 2005
    ..Recently, it has been shown both in vitro and in vivo that several intravenous anesthetics have anti-inflammatory effects...
  59. ncbi Adrenocortical dysfunction following etomidate induction in emergency department patients
    C L Schenarts
    Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-4700, USA
    Acad Emerg Med 8:1-7. 2001
    ..However, cortisol levels remain within normal laboratory levels during this period of dysfunction. Adrenocortical dysfunction appears to resolve within 12 hours of a single bolus dose of 0.3 mg/kg etomidate...
  60. ncbi Intravenous dexamethasone pretreatment reduces fentanyl-induced cough
    Jui An Lin
    Department of Anesthesiology, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    J Formos Med Assoc 106:649-55. 2007
    ..Fentanyl is regularly used in clinical anesthesia practice but fentanyl-induced cough (FIC) will sometimes bother anesthesiologists. This study was designed to examine the effect of intravenous (IV) dexamethasone (DEX) on FIC...
  61. ncbi Comparison of four strategies to reduce the pain associated with intravenous administration of rocuronium
    A B Chiarella
    Department of Anesthesiology and Pain Medicine, 3B2 32 Walter C Mackenzie Health Sciences Centre, University of Alberta Hospitals, 8440 112 Street, Edmonton, Alberta, Canada T6G 2B7
    Br J Anaesth 90:377-9. 2003
    ..I.V. rocuronium produces intense discomfort at the site of injection in conscious patients. Four strategies to reduce or prevent this discomfort were studied...
  62. ncbi Propofol infusion syndrome: case report and literature review
    Jose Orsini
    Division of Critical Care Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10467 2490, USA
    Am J Health Syst Pharm 66:908-15. 2009
    ..A case of propofol infusion syndrome in a patient with respiratory failure and sepsis is reported...
  63. pmc Midazolam is more likely to cause hypotension than etomidate in emergency department rapid sequence intubation
    Y F Choi
    Accident and Emergency Department, Pamela Youde Nethersole Eastern Hospital, 3, Lok Man Road, Hong Kong SAR
    Emerg Med J 21:700-2. 2004
    ..To compare the haemodynamic effect of low dose midazolam and etomidate as induction agent in emergency department rapid sequence intubation...
  64. ncbi Distinct molecular targets for the central respiratory and cardiac actions of the general anesthetics etomidate and propofol
    Anja Zeller
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    FASEB J 19:1677-9. 2005
    ....
  65. ncbi Propofol infusion syndrome--a fatal case at a low infusion rate
    Tobias M Merz
    Anesth Analg 103:1050. 2006
  66. ncbi Inhibitory effects of intravenous anesthetics on mast cell function
    Takahiro Fujimoto
    Department of Anesthesiology, Graduate School of Medicine, The University of Tokyo, Japan
    Anesth Analg 101:1054-9, table of contents. 2005
    ..In conclusion, midazolam and propofol inhibited both chemotaxis and exocytosis of mast cells, while thiopental only inhibited chemotaxis, and ketamine only inhibited exocytosis...
  67. ncbi The 'propofol infusion syndrome': the facts, their interpretation and implications for patient care
    K Ahlen
    AstraZeneca R and D, Clinical Science, Sweden
    Eur J Anaesthesiol 23:990-8. 2006
    ....
  68. ncbi Etomidate for emergency anaesthesia; mad, bad and dangerous to know?
    C Morris
    Anaesthesia 60:737-40. 2005
  69. ncbi Propofol infusion syndrome associated with short-term large-dose infusion during surgical anesthesia in an adult
    Antonios Liolios
    Department of Intensive Care, Cliniques Universitaires St Luc, Avenue Hippocrate, 10, 1200 Brussels, Belgium
    Anesth Analg 100:1804-6. 2005
    ..There were no other evident causes of lactic acidosis as documented by laboratory data. We believe this is the first report of reversible lactic acidosis associated with a short duration of large-dose propofol anesthesia...
  70. ncbi Preventing the withdrawal response associated with rocuronium injection: a comparison of fentanyl with lidocaine
    Norezalee Ahmad
    Clinical Anesthesiology Specialist, Hospital Sultanah Aminah, Johor Bahru, Malaysia
    Anesth Analg 100:987-90. 2005
    ..05). In conclusion, both fentanyl and lidocaine are effective clinical treatments to alleviate the withdrawal response associated with rocuronium injection, with fentanyl being more effective...
  71. ncbi In vitro effects of intravenous anesthetics on the sphincter of Oddi strips of sheep
    Mustafa Turan
    Department of General Surgery, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey
    Pancreatology 5:215-9. 2005
    b>Intravenous anesthetics are often used for conscious sedation in endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic sphincter of Oddi (SO) manometry...
  72. ncbi Predictors of mortality in patients with suspected propofol infusion syndrome
    Jeffrey J Fong
    Northeastern University School of Pharmacy, Boston, MA, USA
    Crit Care Med 36:2281-7. 2008
    ..To identify predictors of mortality in patients with suspected propofol infusion syndrome and to develop a simple scoring system to identify patients with suspected propofol infusion syndrome who are most at risk of death...
  73. ncbi Early propofol infusion syndrome following cerebral angiographic embolization for giant aneurysm repair. Case report
    Franklin D Westhout
    Department of Neurological Surgery, School of Medicine, University of California at Irvine, USA
    J Neurosurg 106:139-42. 2007
    ..She continued to improve and was discharged from the hospital on postoperative Day 7. The metabolic acidosis and hypotension were thought to be due to propofol-related infusion syndrome...
  74. ncbi Changes in expression of GABAA alpha4 subunit mRNA in the brain under anesthesia induced by volatile and intravenous anesthetics
    Shusuke Sekine
    Department of Anesthesiology, Tokyo Medical University, 160 0023, Tokyo, Japan
    Neurochem Res 31:439-48. 2006
    ..These results indicate that the GABAA receptor alpha4 subunit plays an important role in regulating the anesthetic stage of i.v. anesthetics...
  75. ncbi Etomidate and fatal outcome--even a single bolus dose may be detrimental for some patients
    R Bloomfield
    Br J Anaesth 97:116-7. 2006
  76. ncbi Propofol infusion syndrome
    P C A Kam
    Department of Anaesthetics, University of Sydney, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
    Anaesthesia 62:690-701. 2007
    ..Treatment options are limited. Haemodialysis or haemoperfusion with cardiorespiratory support has been the most successful treatment...
  77. pmc Effect of induction agent on vasopressor and steroid use, and outcome in patients with septic shock
    David Charles Ray
    Department of Anaesthesia, Critical Care and Pain Medicine, Royal Infirmary of Edinburgh, Little France Crescent, Edinburgh EH16 4SA, Scotland, UK
    Crit Care 11:R56. 2007
    ..Etomidate could reduce steroid synthesis and increase the need for vasopressor and steroid therapy. The outcome could be worse than in patients given other induction agents...
  78. ncbi Combined effects of propofol and mild hypothermia on cerebral metabolism and blood flow in rhesus monkey: a positron emission tomography study
    Takashi Ouchi
    Department of Anesthesiology, Tokyo Dental College, Ichikawa General Hospital, 5 11 13 Sugano, Ichikawa 272 8513, Japan
    J Anesth 20:208-14. 2006
    ..This study aimed to evaluate the effects of propofol under normothermic and mild hypothermic temperatures upon rCMRO2, rCBF, and their regional coupling, through direct measurement by positron emission tomography...
  79. ncbi Premedication with intravenous low-dose ketamine suppresses fentanyl-induced cough
    Chun Chang Yeh
    Department of Anesthesiology, Tri Service General Hospital and National Defense Medical Center, Neihu 114, Taipei, Taiwan, Republic of China
    J Clin Anesth 19:53-6. 2007
    ..To evaluate the effect of low-dose ketamine on fentanyl-induced cough...
  80. ncbi Propofol infusion syndrome: a case of increasing morbidity with traumatic brain injury
    Ilya Sabsovich
    Surgical and Trauma Intensive Care Unit, Elmhurst Hospital Center, Mount Sinai School of Medicine, New York, NY, USA
    Am J Crit Care 16:82-5. 2007
    ..Despite several publications on the subject in the past decade, most cases still seem to remain undetectable...
  81. ncbi Persistent depression of contractility and vasodilation with propofol but not with sevoflurane or desflurane in rabbits
    Colin Forbes Royse
    Anaesthesia and Pain Management Research Unit, Department of Pharmacology, University of Melbourne, Victoria, Australia
    Anesthesiology 108:87-93. 2008
    ..Propofol, sevoflurane, and desflurane may cause hemodynamic compromise during anesthesia and critical care management. The aim of the study was to compare these anesthetics during increased dose and recovery to maintenance level...
  82. ncbi Propofol reduces nitric oxide-induced apoptosis in testicular ischemia-reperfusion injury by downregulating the expression of inducible nitric oxide synthase
    H Yagmurdur
    Clinic of Anesthesiology and Reanimation, The Ministry of Health Ankara Research and Training Hospital, Ankara, Turkey
    Acta Anaesthesiol Scand 52:350-7. 2008
    The aim of the present study was to investigate the underlying mechanisms in the preventive effects of intravenous anesthetics on testicular ischemia-reperfusion injury.
  83. ncbi Propofol infusion syndrome: a rare cause of multi-organ failure in a man with complicated myocardial infarction
    Avi Shimony
    Department of Cardiology Intensive Cardiac Care Unit, Soroka University Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Isr Med Assoc J 10:316-7. 2008
  84. ncbi Propofol infusion syndrome during anaesthesia for scoliosis surgery in an adolescent with neonatal progeroid syndrome
    H Hermanns
    Acta Anaesthesiol Scand 50:392-4. 2006
  85. ncbi [Severe lactic acidosis caused by propofol infusion: report of one case]
    Carlos Romero P
    Intensive Care Unit, Hospital Clinico Universidad de Chile, Santiago de Chile
    Rev Med Chil 136:88-92. 2008
    ..5 mg/kg/h, for 8 hours more. The suspicion of PRIS motivated immediate discontinuation of propofol with rapid correction of lactic acidosis and full recovery of the patient...
  86. ncbi The experimental and clinical pharmacology of propofol, an anesthetic agent with neuroprotective properties
    Yoshinori Kotani
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu 502 8585, Japan
    CNS Neurosci Ther 14:95-106. 2008
    ..Recently, EDTA has been reported to exert a neuroprotective effect itself by chelating surplus intracerebral zinc in an ischemia model. This article reviews the neuroprotective effects of propofol and its mechanism of action...
  87. ncbi Reciprocal relationships between general (Propofol) anesthesia and circadian time in rats
    Etienne Challet
    Department of Neurobiology of Rhythms, Institute of Cellular and Integrative Neurosciences, CNRS UMR7168, University L Pasteur, Strasbourg, France
    Neuropsychopharmacology 32:728-35. 2007
    ..Anesthesia-induced hypothermia was not correlated with the phase-shifting effects of propofol anesthesia. From our results, anesthesia itself can reset circadian timing, and acts as a synchronizing cue for the circadian clock...
  88. ncbi Remifentanil vs fentanyl with a target controlled propofol infusion in patients undergoing craniotomy for supratentorial lesions
    A Del Gaudio
    Department of Anaesthesia and Intensive Care IRCCS H Casa Sollievo della Sofferenza, S Giovanni Rotondo, Foggia, Italy
    Minerva Anestesiol 72:309-19. 2006
    ..This study compared the use of remifentanil with that of fentanyl during elective supratentorial craniotomy in a target controlled infusion (TCI)-propofol anesthesia regimen and evaluated the quality of recovery from anesthesia...
  89. ncbi Propofol and thiopental attenuate adenosine triphosphate-sensitive potassium channel relaxation in pulmonary veins
    Woon Seok Roh
    Center for Anesthesiology Research, NE63, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Physiol Lung Cell Mol Physiol 291:L636-43. 2006
    ..We investigated the cellular mechanisms by which the intravenous anesthetics propofol and thiopental alter adenosine triphosphate-sensitive potassium (KATP+) channel relaxation in ..
  90. ncbi [Lactic acidosis associated with propofol during general anaesthesia for neurosurgery]
    J Bordes
    Departement d Anesthesie Reanimation, HIA Sainte Anne, Boulevard Sainte Anne, 83800 Toulon, France
    Ann Fr Anesth Reanim 27:261-4. 2008
    ..Lactic acidosis could be an early marker of PRIS. We report here a case of very early lactic acidosis in a 66-year-old-man receiving propofol during a neurosurgery. The outcome was good after discontinuation of propofol...
  91. ncbi Propofol infusion syndrome in a patient with sepsis
    J J De Waele
    Intensive Care Unit, Ghent University Hospital, Belgium
    Anaesth Intensive Care 34:676-7. 2006
    ..We present a case of a septic patient without neurological illness who developed propofol infusion syndrome...
  92. pmc Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics
    M D Krasowski
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
    Neuropharmacology 41:952-64. 2001
    ..This suggests that mutation of M286 in the GABA(A) beta(2) subunit alters the dimensions of a 'binding pocket' for propofol and related alkylphenol general anesthetics...
  93. ncbi Enhanced visual memory effect for negative versus positive emotional content is potentiated at sub-anaesthetic concentrations of thiopental
    K O Pryor
    Department of Anesthesiology, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Br J Anaesth 93:348-55. 2004
    ..It is not known how gamma aminobutyric acid (GABA)ergic drugs affect the processes involved in memory modulation. This study investigates whether memory for negative emotional stimuli is more refractory to the effects of GABAergic drugs...
  94. ncbi General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit
    Rachel Jurd
    Institute of Pharmacology and Toxicology, University of Zurich, CH 8057 Zurich, Switzerland
    FASEB J 17:250-2. 2003
    ..In these mice, the suppression of noxious-evoked movements in response to the intravenous anesthetics etomidate and propofol is completely abolished, while only slightly decreased with the volatile ..
  95. ncbi The anesthetic mechanism of urethane: the effects on neurotransmitter-gated ion channels
    Koji Hara
    Waggoner Center for Alcohol and Addiction Research and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712 1095, USA
    Anesth Analg 94:313-8, table of contents. 2002
    ..Our results also suggest that small changes in multiple receptor systems can produce anesthesia...
  96. ncbi Effects of volatile and intravenous anesthetics on the uptake of GABA, glutamate and dopamine by their transporters heterologously expressed in COS cells and in rat brain synaptosomes
    M Sugimura
    Department of Anesthesiology, Faculty of Dentistry, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Japan
    Toxicol Lett 123:69-76. 2001
    ..The present study examined the effects of volatile and intravenous anesthetics on the uptake of GABA, glutamate and dopamine in COS cells heterologously expressing the transporters for ..
  97. ncbi Intravenous anesthetics inhibit nonadrenergic noncholinergic lower esophageal sphincter relaxation via nitric oxide-cyclic guanosine monophosphate pathway modulation in rabbits
    A Kohjitani
    Department of Dental Anesthesiology, Okayama University School of Dentistry, Japan
    Anesthesiology 95:176-83. 2001
    ..Nonadrenergic noncholinergic (NANC) nerves have important roles in the regulation of the lower esophageal sphincter (LES) motility and function. The effects of thiopental, ketamine, and midazolam on NANC LES relaxation were investigated...
  98. ncbi Major role for tonic GABAA conductances in anesthetic suppression of intrinsic neuronal excitability
    Mark C Bieda
    Neuroscience Program and Department of Anesthesia, Stanford University, SUMC 288 MC5117, Stanford, CA 94305, USA
    J Neurophysiol 92:1658-67. 2004
    ....
  99. ncbi General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor but not with lipid solubility
    M D Krasowski
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois, USA
    J Pharmacol Exp Ther 297:338-51. 2001
    ..These data suggest steric constraints for the binding site for propofol on the GABA(A) receptor...
  100. ncbi Propofol suppresses the cortical somatosensory evoked potential in rats
    Helene G Logginidou
    Department of Anesthesiology, Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, USA
    Anesth Analg 97:1784-8. 2003
    ..6 +/- 3.4 microg/mL (10.8 50% effective concentration), a measurable response was present in 44.5% of rats. These results suggest that even at large doses, propofol and remifentanil provide adequate conditions for SEP monitoring...
  101. ncbi Does anaesthesia care affect the outcome following craniotomy?
    Kate Leslie
    Staff Anaesthetist, Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Australia
    J Clin Neurosci 9:231-6. 2002

Research Grants61

  1. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2010
    ..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
  2. Discriminative Stimulus Effects of Alcohol in Mice
    Wouter Koek; Fiscal Year: 2007
    ..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. [unreadable] [unreadable] [unreadable]..
  3. NITROXIDERGIC CEREBROVASCULAR TONE DURING ANESTHESIA
    Shailendra Joshi; Fiscal Year: 2005
    ..abstract_text> ..
  4. PHARMACOLOGY OF ANESTHETICS IN HEMORRHAGIC SHOCK
    Ken Johnson; Fiscal Year: 2002
    ..The absence of a scientific foundation to guide the rational selection and administration of intravenous anesthetics during shock represents a huge gap in the anesthesia clinical pharmacology literature...
  5. ANESTHETIC MECHANISMS AND GABA-A RECEPTOR STRUCTURE
    MYLES AKABAS; Fiscal Year: 2001
    ..Many drugs used in the induction of general anesthesia, including benzodiazepines, volatile and intravenous anesthetics and barbiturates potentiate GABA-induced currents...
  6. ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONS
    Igor Kissin; Fiscal Year: 2001
    In the initial project (85-88), we demonstrated that a combination of intravenous anesthetics may provide different outcomes (addition, synergism, or antagonism) regarding different components of anesthesia (e.g...
  7. GENERAL ANESTHETICS AND CLONED VOLTAGE-GATED CHANNELS
    ANA CORREA; Fiscal Year: 2000
    ..The roles played by auxiliary subunits will be investigated. (4) To initiate studies on the action of intravenous anesthetics on voltage-gated ion channels...
  8. ORGAN PROTECTION: ROLE OF ANESTHETICS
    JOHN TINKER; Fiscal Year: 1980
    ..We intend to test large dose fentanyl, large dose morphine, and diazepam intravenous anesthetics using this same model...
  9. AUTONOMIC AND VASCULAR EFFECTS OF ANESTHETICS IN HUMANS
    Thomas Ebert; Fiscal Year: 2000
    ..L-NMMA) to block the synthesis of EDRF/NO before and during administration of either volatile or intravenous anesthetics. Additional studies will be carried out to determine if volatile anesthetics alter either arterial or ..
  10. BRAIN AND SPINAL CORD CONTRIBUTIONS TO ANESTHETIC ACTION
    JOSEPH ANTOGNINI; Fiscal Year: 2005
    ..This information will aid the development of newer and safer anesthetics, as well as lead to clinically useful means of modulating the neurotransmitter systems that are themselves modulated by anesthetics. ..
  11. ANESTHETIC EFFECTS ON SENSORIMOTOR INTEGRATION
    JOSEPH ANTOGNINI; Fiscal Year: 2009
    ..Understanding how and where anesthetics act will eventually lead to the development of better and safer anesthetics, thereby decreasing peri-operative morbidity and mortality and improving public health. ..
  12. The Effect of Sedation on Restorative Sleep
    Avery Tung; Fiscal Year: 2005
    ..Knowledge from this proposal will provide scientific insight into the relationships between anesthesia and sleep, and may lead to more effective clinical use of ICU sedatives. ..
  13. COMPARING THREE ELECTRODE PLACEMENTS TO OPTIMIZE ECT
    Keith Rasmussen; Fiscal Year: 2005
    ..The results of this study will promote more effective and safer treatment of the most severely ill depressed patients. ..
  14. Anesthetic Binding Sites on Three-Helix Bundle Proteins
    Jonas Johansson; Fiscal Year: 2006
    ..A precise structural description of the anesthetic binding site on this model system will allow a focused search of the Protein Data Bank for potential binding sites on existing- and future entries. ..
  15. Microarray analysis of neuronal ischemic preconditioning
    Piyush Patel; Fiscal Year: 2007
    ..A substantial benefit of the research will be the identification of novel therapeutic targets upon which future drug development can be based. ..
  16. CRH Antagonists for Treatment of Drug Abuse
    James Woods; Fiscal Year: 2005
    ..This may provide information about the etiology of drug abuse, as well as data on the potential treatment of drug abuse in normal, or particularly, in stressed individuals. ..
  17. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2006
    ..abstract_text> ..
  18. SECOND INTERNATIONAL CONFERENCE PEDIATRIC CARDIAC DEVICE
    Akif Undar; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  19. Dynamic Signal Processing Analyses of Neural Plasticity
    Emery Brown; Fiscal Year: 2006
    ..abstract_text> ..
  20. NARCOTIC DRUG AND OPIOID PEPTIDE BASIC RESEARCH PROJECT
    James Woods; Fiscal Year: 2006
    ..abstract_text> ..
  21. Functional Analysis of GABAerglc Sedative/Anxiolytics
    NANCY ATOR; Fiscal Year: 2007
    ..abstract_text> ..
  22. Neurophysiologic Development Responses to Surgery
    DOUGLAS RIRIE; Fiscal Year: 2007
    ..Through this and future studies which come from this data and training, improvement in understanding will hopefully lead to improved pain therapy that is developmentally appropriate. ..
  23. STATISTICAL ANALYSIS OF HIPPOCAMPAL INFORMATION ENCODING
    Emery Brown; Fiscal Year: 2008
    ..More accurate characterizations of neuronal dynamics may also lead to more physiologically-sound approaches to creating machine-brain interfaces and designing neural prosthetic devices. ..
  24. Pharmacotherapy of Cannabinoid Withdrawal: Pre-Clinical Studies
    Lance R McMahon; Fiscal Year: 2010
    ..Collectively, these specific aims provide a framework for developing novel pharmacotherapies of marijuana withdrawal that could markedly decrease marijuana use and dependence. ..
  25. Ischemic Stroke Treatment with Microbubbles, a Novel Clot Lysis Therapeutic
    William C Culp; Fiscal Year: 2010
    ..Our proposed pilot study will determine which of these treatments is most successful, and future studies will further explore that treatment. (End of Abstract) ..
  26. Behavioral and Pharmacological Analysis of Drugs of Abuse
    JERROLD WINTER; Fiscal Year: 2008
    ..This likelihood coupled with continued interest in the therapeutic use of agents such as psilocybin makes a detailed pharmacological assessment of these drugs of utmost importance. ..
  27. VOLATILE ANESTHETICS AND RESPIRATORY NEUROTRANSMISSION
    Eckehard Stuth; Fiscal Year: 2009
    ....
  28. Development of Esterases for the Treatment of Cocaine Overdose and Abuse
    James Woods; Fiscal Year: 2009
    ..These procedures are designed to prolong the enzyme's duration of action with the hopeful outcome that some insight will be obtained into how to make this substance useful in the long-term treatment of cocaine abuse. ..
  29. Dynamic Analyses of Learning in Behavioral Experiments
    Emery Brown; Fiscal Year: 2009
    ....
  30. FOURTH INTERNATIONAL CONFERENCE ON PEDIATRIC CARDIAC DEVICES
    Akif Undar; Fiscal Year: 2008
    ..This will be the only national/international conference to focus solely on pediatric cardiac patients. (End of Abstract) [unreadable] [unreadable] [unreadable]..
  31. SITES AND MECHANISMS OF INHALED ANESTHETIC ACTIONS
    EDMOND EGER; Fiscal Year: 2008
    ..abstract_text> ..
  32. Genes Underlying the Response to Inhaled Anesthetics
    James Sonner; Fiscal Year: 2008
    ....
  33. Drug discrimination and THC withdrawal in monkeys
    LANCE MCMAHON; Fiscal Year: 2005
    ..abstract_text> ..
  34. Increasing Functional Liver Mass in Health and Disease
    Leonidas Koniaris; Fiscal Year: 2005
    ..2) Determine the extent to which and mechanisms by which co-administrating HCF and Follistatin along with IL-6 facilitates the liver growth response and reduces IL-6 associated toxicity. ..
  35. Cerebal Ischemia During Anesthesia and Surgery
    Piyush Patel; Fiscal Year: 2004
    ..The long term goals of the research are to prevent the occurrence of isehemic brain injury in patients undergoing anesthesia and surgery. ..
  36. Ethanol and synaptic plasticity in the cerebellum
    CHIMING HUANG; Fiscal Year: 2004
    ..To ensure that the observed synaptic reorganization/loss and functional deficit occur without significant cell loss, we will employ unbiased stereology to evaluate the number of granule cells and Purkinje cells. ..
  37. MODERATE ALCOHOL CONSUMPTION AND HDL
    WILLEM DEVILLIERS; Fiscal Year: 2003
    ..This will be done by measuring the bioactivity of paraoxonase and determining the ability of HDL from human subjects exposed to alcohol to protect against macrophage-mediated LDL. ..
  38. ANESHETIC MODULATION OF NATIVE NICOTINIC RECEPTORS
    Pamela Flood; Fiscal Year: 2003
    ..The resulting information will provide understanding of the molecular mechanism underlying one of the anesthetic effects that limit anesthetic safety. ..
  39. EVALUATION OF PROTEIN BASED MEDICATIONS AGAINST COCAINE
    James Woods; Fiscal Year: 2003
    ..Studies in which the ability of BChE and Mab 15A10 to produce increases in the cocaine metabolite, egconine methyl ester are planned to demonstrate that both of these medications increase the rate of cocaine metabolism. ..
  40. Developmental Studies of Sound Localization Mechanisms
    DANIEL TOLLIN; Fiscal Year: 2003
    ....
  41. Biobehavioral Heterogeneity of Crack Cocaine Dependence
    Leslie Prichep; Fiscal Year: 2003
    ..Application of new mathematical algorithms will permit identification of the most probable neuroanatomical sources generating the QEEG, which may improve understanding of underlying mechanisms and help target new medications. ..
  42. Exacerbation of Alzheimer's Disease by Nitrous Oxide
    W Kofke; Fiscal Year: 2003
    ..Moreover, observation of a protective effect may result in discovery of an easily implemented preventative drug therapy for AD. ..
  43. CD36 AND HEPATIC STELLATE CELL ACTIVATION
    WILLEM DEVILLIERS; Fiscal Year: 2002
    ..We will determine whether spontaneously hypertensive rats and CD36-deficient mice are resistant to the development of hepatic fibrosis. ..
  44. BCHE as a Cocaine Antagonist
    James Woods; Fiscal Year: 2002
    ..The possibility that human BChE can eventually be used as a safe and effective treatment of cocaine abuse and toxicity is being explored through these studies. ..
  45. STATISTICAL ANALYSIS OF HUMAN CIRCADIAN RHYTHMS
    Emery Brown; Fiscal Year: 2001
    ....
  46. SENESCENCE ALTERS SYMPATHETIC REGULATION TO HEAT STRESS
    MICHAEL KENNEY; Fiscal Year: 2004
    ..The proposed studies will, for the first time, advance the hypothesis that the working strategies employed by sympathetic neural circuits to respond to heat stress are modified by aging. ..
  47. Oral Care and Respiratory Pathogen Colonization
    Ozan Akca; Fiscal Year: 2004
    ..Reducing respiratory pathogen colonization in the mouth could significantly reduce the morbidity and cost of VAP. ..
  48. Stress, Rearing, and Ethanol Reinforcement in Monkeys
    James Woods; Fiscal Year: 2005
    ..These studies will contribute to a better understanding of the biological basis of alcoholism, which is a first step toward the development of effective pharmacotherapeutic interventions. ..
  49. Strategies for Improving Sedation Outcomes in the ICU
    JOHN KRESS; Fiscal Year: 2005
    ..abstract_text> ..
  50. PEDIATRIC MECHANICAL CIRCULATORY SUPPORT SYSTEMS
    Akif Undar; Fiscal Year: 2005
    ..The manuscripts from all of the contributors including key note, invited, slide and poster presenters will be peer-reviewed and will be published in the November-December 2005 issue of the ASAIO Journal. ..
  51. The Role of GDF-15 in Organ Injury
    Leonidas Koniaris; Fiscal Year: 2005
    ..The completion of this mentored research training will further the candidate?s goal of applying bench-derived scientific discovery to the treatment of surgical disease as an independent investigator. ..
  52. BEHAVIORAL & PHARMACOLOGICAL ANALYSIS OF DRUGS OF ABUSE
    JERROLD WINTER; Fiscal Year: 2005
    ..abstract_text> ..
  53. Sympathetic-Immune Interface: Central Sites & Function
    MICHAEL KENNEY; Fiscal Year: 2005
    ..Ultimately, these findings may allow for the design of intervention strategies in immune regulation fostering robust and appropriate communication between the immune and nervous systems. ..
  54. Pain Assessment in Cognitively Impaired Children
    Shobha Malviya; Fiscal Year: 2005
    ..A reliable and valid pain assessment tool is critical to facilitate our future study of pain management strategies in these children. ..
  55. Statistical Modeling of Functional MRI Signals
    Emery Brown; Fiscal Year: 2004
    ..abstract_text> ..
  56. Novel direct vago-vagal recording of i.v. ghrelin action
    David Adelson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  57. Sodium Channel Blockers as Inhibitors of Prostate Cancer
    Milton Brown; Fiscal Year: 2008
    ..abstract_text> ..
  58. Gastric Tube Placement in Young Children
    Marsha Ellett; Fiscal Year: 2008
    ..Results from this study will increase the safety of using gastric tubes in young children. ..
  59. BLOOD PRESSURE CONTROL BY FOREBRAIN & BRAINSTEM NEURONS
    SUSAN BARMAN; Fiscal Year: 2008
    ..unreadable] [unreadable]..