Genomes and Genes
Summary: Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)
Publications222 found, 100 shown here
- Intravenous anesthetics differentially modulate ligand-gated ion channelsP Flood
Department of Anesthesiology, Columbia University, New York, New York 10032, USA
Anesthesiology 92:1418-25. 2000..nAChRs) are potently inhibited by volatile anesthetics, but it is not known whether they are affected by intravenous anesthetics. Ketamine potentiates gamma-aminobutyric acid type A (GABAA) receptors at high concentrations, but it is ..
- Dose-dependent effects of propofol on the central processing of thermal painRobert K Hofbauer
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
Anesthesiology 100:386-94. 2004..Anatomic and physiologic data show that multiple regions of the forebrain are activated by pain. However, the effect of anesthetic level on nociceptive input to these regions is not well understood...
- Facilitation of serotonergic activity and amnesia in rats caused by intravenous anestheticsKazunori Semba
Department of Anesthesiology and Resuscitology, Ehime University School of Medicine, Japan
Anesthesiology 102:616-23. 2005..Because an increase in central serotonergic activity impairs learning and memory, the authors examined the relation between changes in the serotonergic activity caused by intravenous anesthetics and memory.
- Sleep deprivation potentiates the onset and duration of loss of righting reflex induced by propofol and isofluraneAvery Tung
Department of Anesthesia and Critical Care, University of Chicago, Illinois, USA
Anesthesiology 97:906-11. 2002..Changes in the propensity to sleep may then modify the response to anesthetic agents. The authors tested the hypothesis that sleep-deprived rats would require less anesthetic than rested rats to achieve a similar loss of responsiveness...
- The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: a comparative studyM Pistis
Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee
Br J Pharmacol 122:1707-19. 1997..However, the presence on glycine receptors of lower affinity modulatory binding sites for pentobarbitone, propofol and trichloroethanol may aid in the identification of the molecular determinants of the CNS actions of these anaesthetics...
- The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acidD Belelli
Neurosciences Institute, Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, Dundee University, Dundee, DD1 9SY, United Kingdom
Proc Natl Acad Sci U S A 94:11031-6. 1997..Together with the lack of effect of intracellular etomidate, the data argue against a unitary, lipid-based theory of anesthesia...
- The effects of general anaesthetics on carbachol-evoked gamma oscillations in the rat hippocampus in vitroR Dickinson
Biophysics Group, Imperial College of Science, Technology and Medicine, Blackett Laboratory, Prince Consort Road, London SW7 2BW, UK
Neuropharmacology 44:864-72. 2003....
- Inhalational or intravenous anesthetics for craniotomies? Pro inhalationalKristin Engelhard
Klinik fur Anasthesiologie, Johannes Gutenberg Universitat, Mainz, Germany
Curr Opin Anaesthesiol 19:504-8. 2006....
- A comparison of pharmacokinetic/pharmacodynamic versus mass-balance measurement of brain concentrations of intravenous anesthetics in sheepLogan J Voss
Department of Anaesthesia and Intensive Care, University of Adelaide and Royal Adelaide Hospital, North Terrace, Adelaide University, Adelaide, South Australia, Australia
Anesth Analg 104:1440-6, table of contents. 2007....
- Effects of halothane and propofol on excitatory and inhibitory synaptic transmission in rat cortical neuronsAkira Kitamura
Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
J Pharmacol Exp Ther 304:162-71. 2003..The additional calcium-dependent inhibition of mIPSC and mEPSC frequency by halothane (but not propofol) suggests a more general mechanism by this anesthetic on presynaptic transmitter release...
- Endocrine stress response and inflammatory activation during CABG surgery. A randomized trial comparing remifentanil infusion to intermittent fentanylM Winterhalter
Hannover Medical School, Department of Anaesthesiology, Hannover, Germany
Eur J Anaesthesiol 25:326-35. 2008....
- Effects of intravenous anesthetics on renal ischemia/reperfusion injuryHusamettin Yuzer
Department of General Surgery, Faculty of Medicine, Kahramanmaras Sutcuimam University, Kahramanmaras, Turkey
Ren Fail 31:290-6. 2009..Aim. The purpose of this study was to investigate and compare the efficiency of ketamine, thiopental, propofol, etomidate, and intralipid in reducing the injury induced by free radicals in a rat model of renal I/R...
- Propofol anesthesia and cerebral blood flow changes elicited by vibrotactile stimulation: a positron emission tomography studyV Bonhomme
Department of Anesthesia, McGill University, Montreal, Quebec H3A 1A2, Canada
J Neurophysiol 85:1299-308. 2001..We conclude that propofol interferes with the processing of vibrotactile information first at the level of the cortex before attenuating its transfer through the thalamus...
- Propofol directly depresses lumbar dorsal horn neuronal responses to noxious stimulation in goatsJ F Antognini
Department of Anesthesiology and Pain Management, University of California, Davis 95616, USA
Can J Anaesth 47:273-9. 2000..We recorded the response of lumbar dorsal horn neurons during differential delivery of propofol to the brain and torso of goats...
- Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isofluraneM D Krasowski
Department of Committee on Neurobiology, University of Chicago, Chicago, Illinois 60637, USA
Mol Pharmacol 53:530-8. 1998..In most cases, these mutations had little or no effect on the actions of these intravenous anesthetics. However, a point mutation in the beta1 subunit (M286W) abolished potentiation of GABA by propofol but ..
- Predictors of hypotension after induction of general anesthesiaDavid L Reich
Department of Anesthesiology, Mount Sinai Medical Center, Box 1010, One Gustave L Levy Place, New York, NY 10029 6574, USA
Anesth Analg 101:622-8, table of contents. 2005..g., etomidate) should be considered in patients older than 50 yr of age with ASA physical status > or =3. We conclude that it is advisable to avoid propofol induction in patients who present with baseline MAP <70 mm Hg...
- The differential effects of intravenous anesthetics on myofilament Ca2+ sensitivity in pulmonary venous smooth muscleXueqin Ding
Center for Anesthesiology Research, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Anesth Analg 105:1278-86, table of contents. 2007..In the present study, we investigated the direct effects of ketamine, etomidate, thiopental, and midazolam on pulmonary venous contraction and myofilament Ca2+ sensitivity in permeabilized pulmonary venous smooth muscle (PVSM)...
- Gene regulatory control of myocardial energy metabolism predicts postoperative cardiac function in patients undergoing off-pump coronary artery bypass graft surgery: inhalational versus intravenous anestheticsEliana Lucchinetti
Institute of Anesthesiology, University Hospital Zurich, and Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland
Anesthesiology 106:444-57. 2007..This study aimed at identifying myocardial transcriptional phenotypes to predict cardiovascular biomarkers and function in patients undergoing off-pump coronary artery bypass graft surgery...
- Propofol (Diprivan-EDTA) counteracts oxidative injury and deterioration of the arterial oxygen tension during experimental septic shockS Basu
Department of Geriatrics and Clinical Nutrition Research, Uppsala University Hospital, S 751 85 Uppsala, Sweden
Resuscitation 50:341-8. 2001..CONCLUSIONS: Propofol reduced endotoxin-induced free radical mediated and cyclooxygenase catalysed lipid peroxidation significantly. The implication is that propofol counteracts endotoxin-induced deterioration of PaO(2)...
- Intravenous anesthetics are more effective than volatile anesthetics on inhibitory pathways in rat hippocampal CA1Takehisa Asahi
Department of Anesthesiology, University of Toyama, Toyama City, Toyama, Japan
Anesth Analg 102:772-8. 2006....
- Effects of intravenous anesthetics on interleukin (IL)-6 and IL-10 production by lipopolysaccharide-stimulated mononuclear cells from healthy volunteersM Takaono
Division of Clinical Immunology, Clinical Research Institute, International Medical Center of Japan, Tokyo, Japan
Acta Anaesthesiol Scand 46:176-9. 2002..The aim of this study was therefore to examine the effects of intravenous anesthetics on the synthesis of interleukin (IL)-6 (a proinflammatory cytokine) and IL-10 (an anti-inflammatory ..
- Memory function during propofol and alfentanil anesthesia: predictive value of individual differencesChantal Kerssens
Department of Anesthesiology, University Hospital Rotterdam, The Netherlands
Anesthesiology 97:382-9. 2002..The present study investigated memory function during deep sedation (BIS, 60-70). As memory effects are small, the authors studied potential predictors of individual differences in memory performance...
- Effects of intravenous anesthetics on the activity of glutamate transporter EAAT3 expressed in Xenopus oocytes: evidence for protein kinase C involvementJung Yeon Yun
Department of Anesthesiology and Clinical Research Institute, Seoul National University Hospital College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, South Korea
Eur J Pharmacol 531:133-9. 2006We investigated the effects of the intravenous anesthetics, thiopental, etomidate and ketamine, on the activity of one type of glutamate transporters, EAAT3 (excitatory amino acid transporter type 3)...
- The effects of local and intravenous anesthetics on recombinant rat VR1 vanilloid receptorsKazuyoshi Hirota
Department of Anesthesiology, University of Hirosaki School of Medicine, Japan
Anesth Analg 96:1656-60, table of contents. 2003..In conclusion, the present data suggest that local but not IV general anesthetics interact with recombinant rat VR1 receptors with the former anesthetics having antagonistic activity...
- Propofol-associated dilation of rat distal coronary arteries is mediated by multiple substances, including endothelium-derived nitric oxideK W Park
Department of Anesthesia and Critical Care, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Anesth Analg 81:1191-6. 1995..This effect is primarily endothelium-dependent and is mediated by multiple substances, including nitric oxide (NO) and a vasodilatory prostanoid. The effect is not mediated by opening of the K(ATP) channels...
- Guidelines for the use of deep sedation and anesthesia for GI endoscopyDouglas O Faigel
Gastrointest Endosc 56:613-7. 2002
- Why we still use intravenous drugs as the basic regimen for neurosurgical anaesthesiaPol Hans
University Department of Anaesthesia and Intensive Care Medicine, CHR de la Citadelle, Liege University Hospital, Liege, Belgium
Curr Opin Anaesthesiol 19:498-503. 2006..Consequently, new adjustments of anaesthesia should aim at providing brain relaxation, minimal interference with electrophysiological monitoring, rapid recovery, patients' cooperation during surgery and neuroprotection...
- Changes in the effect of propofol in response to altered plasma protein binding during normothermic cardiopulmonary bypassE Takizawa
Department of Anaesthesiology, Saitama Cardiovascular and Pulmonary Centre, 1696 Itai Konan machi Osato gun, Saitama 360 0105, Japan
Br J Anaesth 96:179-85. 2006..The purpose of this study was to assess changes in the drug effect of propofol in response to altered plasma binding using quantitative EEG measurements...
- Should etomidate be the induction agent of choice for rapid sequence intubation in the emergency department?A J Oglesby
Department of Accident and Emergency Medicine, The Royal Infirmary of Edinburgh, Old Dalkeith Road, Edinburgh EH16 4SU, UK
Emerg Med J 21:655-9. 2004..Important questions regarding the medium to long term effects on adrenocortical function (even after a single dose) remain unanswered...
- Lactic acidosis: an early marker of propofol infusion syndrome?Marc Koch
Intensive Care Med 30:522. 2004
- Plasma propofol concentration and EEG burst suppression ratio during normothermic cardiopulmonary bypassK Yoshitani
Department of Anaesthesiology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
Br J Anaesth 90:122-6. 2003..This topic has not been studied extensively during normothermic CPB. In this study, we related propofol dose to plasma propofol concentration and burst suppression of the EEG during normothermic bypass...
- Preoperative anxiety and propofol requirement in conscious sedation for ovum retrievalJeong Yeon Hong
Department of Anesthesiology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
J Korean Med Sci 18:863-8. 2003....
- The syndrome of irreversible acidosis after prolonged propofol infusionMonisha A Kumar
Vascular and Critical Care Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Neurocrit Care 3:257-9. 2005..The pathogenesis of this syndrome is thought to be activation of the systemic inflammatory response, which culminates in acidosis and muscle necrosis...
- Response Entropy is not more sensitive than State Entropy in distinguishing the use of esmolol instead of remifentanil in patients undergoing gynaecological laparoscopyM Valjus
Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
Acta Anaesthesiol Scand 50:32-9. 2006..Our hypothesis was that while keeping SE at a predetermined level, RE would be higher in patients receiving a beta-blocking agent (esmolol) instead of an opioid (remifentanil) during a propofol/nitrous oxide anaesthesia...
- Intravenous anesthetics inhibit capacitative calcium entry in pulmonary venous smooth muscle cellsSachiko Shimizu
Center for Anesthesiology Research, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Anesthesiology 104:791-7. 2006..kinase C, tyrosine kinase (TK), and rho-kinase signaling pathways in regulating CCE; and to investigate the extent and cellular mechanisms by which intravenous anesthetics (thiopental, midazolam, ketamine, and propofol) alter CCE.
- Overestimation of Bispectral Index in sedated intensive care unit patients revealed by administration of muscle relaxantBenoit Vivien
Department of Anesthesiology, Universitaire Pitié Salpêtrière, Paris, France
Anesthesiology 99:9-17. 2003..This study aimed to investigate the magnitude of the decrease of BIS following administration of muscle relaxant in sedated intensive care unit patients...
- The effects of enflurane, isoflurane, and intravenous anesthetics on rat diaphragmatic function and fatigabilityKahoru Nishina
Department of Anaesthesia and Perioperative Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
Anesth Analg 96:1674-8, table of contents. 2003..Our results also indicate that large concentrations of enflurane may impair the diaphragmatic function at sites other than excitation-contraction coupling...
- Pretreatment with thiopental for prevention of pain associated with propofol injectionAnil Agarwal
Departments of Anesthesia and Biostatistics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Anesth Analg 98:683-6, table of contents. 2004..05). Thiopental 0.5 mg/kg was the most effective treatment. We therefore suggest routine pretreatment with thiopental 0.5 mg/kg along with venous occlusion for 1 min for prevention of pain associated with propofol injection...
- The influence of hemorrhagic shock on propofol: a pharmacokinetic and pharmacodynamic analysisKen B Johnson
Department of Anesthesiology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Anesthesiology 99:409-20. 2003..To investigate this further, the authors studied the influence of hemorrhagic shock on the pharmacology of propofol in a swine isobaric hemorrhage model...
- Survival of propofol infusion syndrome in a head-injured patientStephanie Mallow Corbett
Department of Surgery, Division of Trauma Critical Care, University of Vermont College of Medicine Burlington, USA
Crit Care Med 34:2479-83. 2006..To describe the clinical progression of an adult patient with traumatic brain injury who survived propofol infusion syndrome...
- Differential interaction of anaesthetics and antiepileptic drugs with neuronal Na+ channels, Ca2+ channels, and GABA(A) receptorsR Lingamaneni
Department of Anesthesiology, Box 50, LC 203A, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
Br J Anaesth 90:199-211. 2003..We compared the interactions of representative agents from each class on their putative targets using well-characterized radioligand binding assays...
- Anesthetic-induced burst suppression EEG activity requires glutamate-mediated excitatory synaptic transmissionHeath S Lukatch
Stanford Neuroscience Program and Neuropharmacology Laboratory, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
Cereb Cortex 15:1322-31. 2005..A GABA(A) agonist produced a similar EEG effect to the anesthetics. It appears that anesthetic effects at both glutamate and GABA synapses contribute to EEG patterns seen during anesthesia...
- The mechanisms of the direct action of etomidate on vascular reactivity in rat mesenteric resistance arteriesKazuhiro Shirozu
Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Kyushu University, Fukuoka 812 8582, Japan
Anesth Analg 108:496-507. 2009..e., cerebral protection) in patients with advanced age or heart disease, and during cardiopulmonary bypass. However, less is known about its action on systemic resistance arteries...
- A unitary anesthetic binding site at high resolutionL Sangeetha Vedula
Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 284:24176-84. 2009..Finally, apoferritin displays both structural and dynamic responses to anesthetic binding, which may mimic changes elicited by anesthetics in physiologic targets like ion channels...
- Incidence of propofol infusion syndrome during noninvasive radiofrequency ablation for atrial flutter or fibrillationGrant T Cravens
Anesthesiology Department, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Anesthesiology 106:1134-8. 2007..Propofol infusion syndrome is first manifest by unexplained metabolic acidosis. Its incidence is unknown...
- Effect of intravenous anesthetics on inward rectifier potassium current in rat and human ventricular myocytesC A Carnes
College of Pharmacy, The Ohio State University, Columbus 43210, USA
Anesthesiology 87:327-34. 1997..Inhibition of the inward rectifying potassium current (I(K1)) may cause cardiac dysrhythmias by decreasing resting membrane potential or prolonging action potential...
- Functional comparison of anaesthetic agents during myocardial ischaemia-reperfusion using pressure-volume loopsD T Andrews
Cardiovascular and Therapeutics Unit, Department of Pharmacology, University of Melbourne, Melbourne, Australia
Br J Anaesth 103:654-64. 2009..Left ventricular (LV) pressure-volume (PV) loops were used to compare the functional effects that accompany the cardioprotection seen with desflurane, sevoflurane, and propofol in a rabbit preparation of coronary ischaemia-reperfusion (IR)...
- Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug deliveryG Trapani
Dipartimento Farmaco Chimico, Facolta di Farmacia, Universita degli Studi di Bari, Via Orabona 4, Bari, 70125, Italy
Curr Med Chem 7:249-71. 2000....
- Population pharmacokinetics of propofol: a multicenter studyJ Schuttler
Department of Anesthesiology, Friedrich Alexander University of Erlangen Nuremberg, Germany
Anesthesiology 92:727-38. 2000..This method requires accurate knowledge of pharmacokinetics, including the effects of age and weight. The authors performed a multicenter population analysis to quantitate the effects of covariates...
- Short-term low-dose propofol anaesthesia associated with severe metabolic acidosisA Chukwuemeka
Division of Cardiovascular Surgery, Department of Surgery, Toronto General Hospital and University of Ontario, Canada
Anaesth Intensive Care 34:651-5. 2006..This report discusses an unusual adverse effect of propofol anaesthesia and sedation and highlights the need for further investigation to define propofol toxicity...
- Effects of propofol on endotoxin-induced acute lung injury in rabbitSang Hyun Kwak
Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, 8 Hakdong, Dong Gu, Gwangju 501 757, Korea s
J Korean Med Sci 19:55-61. 2004..In conclusion, propofol attenuated endotoxin-induced acute lung injury in rabbits mainly by inhibiting neutrophil and IL-8 responses, which may play a central role in sepsis-related lung injury...
- Skin impedance correlates to sedation grade, plasma propofol concentrations and bispectral index during a target-controlled infusion of propofolMichael Winterhalter
Department of Anaesthesiology, University of Duesseldorf, Duesseldorf, Germany
Eur J Anaesthesiol 26:589-96. 2009..The aim of this prospective study was to evaluate electrical skin impedance in comparison with bispectral index values and the Observer's Assessment of Alertness and Sedation (OAAS) scale during propofol infusion...
- Lacticacidosis after short-term infusion of propofol for anaesthesia in a child with osteogenesis imperfectaClemens Kill
Department of Anaesthesiology and Intensive Care Medicine, Philipps University, Marburg, Germany
Paediatr Anaesth 13:823-6. 2003..The highest lactate concentration was 9.2 mmol.l-1 at 160 min after discontinuation of propofol. There was no significant increase in body temperature. The boy fully recovered...
- Propofol attenuates ovalbumin-induced smooth muscle contraction of the sensitized rat trachea: inhibition of serotonergic and cholinergic signalingMasakazu Yamaguchi
Department of Anesthesiology, Nagasaki University School of Medicine, Nagasaki, Japan
Anesth Analg 103:594-600. 2006..These results suggest that the mechanism involved in the attenuation by propofol of OA-induced contraction is inhibition of the actions of 5-HT. Propofol should be a useful anesthetic in patients with immunoglobulin E-related asthma...
- Propofol infusion syndrome: an overview of a perplexing diseaseVincenzo Fodale
Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina, Messina, Italy
Drug Saf 31:293-303. 2008..So, PRIS must be kept in mind as a rare, but highly lethal, complication of propofol use, not necessarily confined to its prolonged use. Furthermore, the safe dosage of propofol may need re-evaluation, and new studies are needed...
- Intravenous lidocaine and ephedrine, but not propofol, suppress fentanyl-induced coughChin Shuang Lin
Department of Anesthesiology, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei, Taiwan 100
Can J Anaesth 51:654-9. 2004..The aim of this study was to evaluate the effectiveness of lidocaine, propofol and ephedrine in suppressing fentanyl-induced cough...
- Dose effects of propofol on hemodynamic and cytokine responses to endotoxemia in ratsYasuhiro Takemoto
Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, 920 8641, Japan
J Anesth 19:40-4. 2005..The purpose of this study was to elucidate whether these beneficial effects of propofol on hemodynamics and cytokine responses were dose related...
- Anti-inflammatory effects of intravenous anesthetics on endotoxemiaTakumi Taniguchi
Department of Emergency and Critical Care Medicine, Graduate School of Medical Science, Kanazawa University, Japan
Mini Rev Med Chem 5:241-5. 2005..Recently, it has been shown both in vitro and in vivo that several intravenous anesthetics have anti-inflammatory effects...
- Adrenocortical dysfunction following etomidate induction in emergency department patientsC L Schenarts
Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-4700, USA
Acad Emerg Med 8:1-7. 2001..However, cortisol levels remain within normal laboratory levels during this period of dysfunction. Adrenocortical dysfunction appears to resolve within 12 hours of a single bolus dose of 0.3 mg/kg etomidate...
- Intravenous dexamethasone pretreatment reduces fentanyl-induced coughJui An Lin
Department of Anesthesiology, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
J Formos Med Assoc 106:649-55. 2007..Fentanyl is regularly used in clinical anesthesia practice but fentanyl-induced cough (FIC) will sometimes bother anesthesiologists. This study was designed to examine the effect of intravenous (IV) dexamethasone (DEX) on FIC...
- Comparison of four strategies to reduce the pain associated with intravenous administration of rocuroniumA B Chiarella
Department of Anesthesiology and Pain Medicine, 3B2 32 Walter C Mackenzie Health Sciences Centre, University of Alberta Hospitals, 8440 112 Street, Edmonton, Alberta, Canada T6G 2B7
Br J Anaesth 90:377-9. 2003..I.V. rocuronium produces intense discomfort at the site of injection in conscious patients. Four strategies to reduce or prevent this discomfort were studied...
- Propofol infusion syndrome: case report and literature reviewJose Orsini
Division of Critical Care Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10467 2490, USA
Am J Health Syst Pharm 66:908-15. 2009..A case of propofol infusion syndrome in a patient with respiratory failure and sepsis is reported...
- Midazolam is more likely to cause hypotension than etomidate in emergency department rapid sequence intubationY F Choi
Accident and Emergency Department, Pamela Youde Nethersole Eastern Hospital, 3, Lok Man Road, Hong Kong SAR
Emerg Med J 21:700-2. 2004..To compare the haemodynamic effect of low dose midazolam and etomidate as induction agent in emergency department rapid sequence intubation...
- Distinct molecular targets for the central respiratory and cardiac actions of the general anesthetics etomidate and propofolAnja Zeller
Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
FASEB J 19:1677-9. 2005....
- Propofol infusion syndrome--a fatal case at a low infusion rateTobias M Merz
Anesth Analg 103:1050. 2006
- Inhibitory effects of intravenous anesthetics on mast cell functionTakahiro Fujimoto
Department of Anesthesiology, Graduate School of Medicine, The University of Tokyo, Japan
Anesth Analg 101:1054-9, table of contents. 2005..In conclusion, midazolam and propofol inhibited both chemotaxis and exocytosis of mast cells, while thiopental only inhibited chemotaxis, and ketamine only inhibited exocytosis...
- The 'propofol infusion syndrome': the facts, their interpretation and implications for patient careK Ahlen
AstraZeneca R and D, Clinical Science, Sweden
Eur J Anaesthesiol 23:990-8. 2006....
- Etomidate for emergency anaesthesia; mad, bad and dangerous to know?C Morris
Anaesthesia 60:737-40. 2005
- Propofol infusion syndrome associated with short-term large-dose infusion during surgical anesthesia in an adultAntonios Liolios
Department of Intensive Care, Cliniques Universitaires St Luc, Avenue Hippocrate, 10, 1200 Brussels, Belgium
Anesth Analg 100:1804-6. 2005..There were no other evident causes of lactic acidosis as documented by laboratory data. We believe this is the first report of reversible lactic acidosis associated with a short duration of large-dose propofol anesthesia...
- Preventing the withdrawal response associated with rocuronium injection: a comparison of fentanyl with lidocaineNorezalee Ahmad
Clinical Anesthesiology Specialist, Hospital Sultanah Aminah, Johor Bahru, Malaysia
Anesth Analg 100:987-90. 2005..05). In conclusion, both fentanyl and lidocaine are effective clinical treatments to alleviate the withdrawal response associated with rocuronium injection, with fentanyl being more effective...
- In vitro effects of intravenous anesthetics on the sphincter of Oddi strips of sheepMustafa Turan
Department of General Surgery, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey
Pancreatology 5:215-9. 2005b>Intravenous anesthetics are often used for conscious sedation in endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic sphincter of Oddi (SO) manometry...
- Predictors of mortality in patients with suspected propofol infusion syndromeJeffrey J Fong
Northeastern University School of Pharmacy, Boston, MA, USA
Crit Care Med 36:2281-7. 2008..To identify predictors of mortality in patients with suspected propofol infusion syndrome and to develop a simple scoring system to identify patients with suspected propofol infusion syndrome who are most at risk of death...
- Early propofol infusion syndrome following cerebral angiographic embolization for giant aneurysm repair. Case reportFranklin D Westhout
Department of Neurological Surgery, School of Medicine, University of California at Irvine, USA
J Neurosurg 106:139-42. 2007..She continued to improve and was discharged from the hospital on postoperative Day 7. The metabolic acidosis and hypotension were thought to be due to propofol-related infusion syndrome...
- Changes in expression of GABAA alpha4 subunit mRNA in the brain under anesthesia induced by volatile and intravenous anestheticsShusuke Sekine
Department of Anesthesiology, Tokyo Medical University, 160 0023, Tokyo, Japan
Neurochem Res 31:439-48. 2006..These results indicate that the GABAA receptor alpha4 subunit plays an important role in regulating the anesthetic stage of i.v. anesthetics...
- Etomidate and fatal outcome--even a single bolus dose may be detrimental for some patientsR Bloomfield
Br J Anaesth 97:116-7. 2006
- Propofol infusion syndromeP C A Kam
Department of Anaesthetics, University of Sydney, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
Anaesthesia 62:690-701. 2007..Treatment options are limited. Haemodialysis or haemoperfusion with cardiorespiratory support has been the most successful treatment...
- Effect of induction agent on vasopressor and steroid use, and outcome in patients with septic shockDavid Charles Ray
Department of Anaesthesia, Critical Care and Pain Medicine, Royal Infirmary of Edinburgh, Little France Crescent, Edinburgh EH16 4SA, Scotland, UK
Crit Care 11:R56. 2007..Etomidate could reduce steroid synthesis and increase the need for vasopressor and steroid therapy. The outcome could be worse than in patients given other induction agents...
- Combined effects of propofol and mild hypothermia on cerebral metabolism and blood flow in rhesus monkey: a positron emission tomography studyTakashi Ouchi
Department of Anesthesiology, Tokyo Dental College, Ichikawa General Hospital, 5 11 13 Sugano, Ichikawa 272 8513, Japan
J Anesth 20:208-14. 2006..This study aimed to evaluate the effects of propofol under normothermic and mild hypothermic temperatures upon rCMRO2, rCBF, and their regional coupling, through direct measurement by positron emission tomography...
- Premedication with intravenous low-dose ketamine suppresses fentanyl-induced coughChun Chang Yeh
Department of Anesthesiology, Tri Service General Hospital and National Defense Medical Center, Neihu 114, Taipei, Taiwan, Republic of China
J Clin Anesth 19:53-6. 2007..To evaluate the effect of low-dose ketamine on fentanyl-induced cough...
- Propofol infusion syndrome: a case of increasing morbidity with traumatic brain injuryIlya Sabsovich
Surgical and Trauma Intensive Care Unit, Elmhurst Hospital Center, Mount Sinai School of Medicine, New York, NY, USA
Am J Crit Care 16:82-5. 2007..Despite several publications on the subject in the past decade, most cases still seem to remain undetectable...
- Persistent depression of contractility and vasodilation with propofol but not with sevoflurane or desflurane in rabbitsColin Forbes Royse
Anaesthesia and Pain Management Research Unit, Department of Pharmacology, University of Melbourne, Victoria, Australia
Anesthesiology 108:87-93. 2008..Propofol, sevoflurane, and desflurane may cause hemodynamic compromise during anesthesia and critical care management. The aim of the study was to compare these anesthetics during increased dose and recovery to maintenance level...
- Propofol reduces nitric oxide-induced apoptosis in testicular ischemia-reperfusion injury by downregulating the expression of inducible nitric oxide synthaseH Yagmurdur
Clinic of Anesthesiology and Reanimation, The Ministry of Health Ankara Research and Training Hospital, Ankara, Turkey
Acta Anaesthesiol Scand 52:350-7. 2008The aim of the present study was to investigate the underlying mechanisms in the preventive effects of intravenous anesthetics on testicular ischemia-reperfusion injury.
- Propofol infusion syndrome: a rare cause of multi-organ failure in a man with complicated myocardial infarctionAvi Shimony
Department of Cardiology Intensive Cardiac Care Unit, Soroka University Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Isr Med Assoc J 10:316-7. 2008
- Propofol infusion syndrome during anaesthesia for scoliosis surgery in an adolescent with neonatal progeroid syndromeH Hermanns
Acta Anaesthesiol Scand 50:392-4. 2006
- [Severe lactic acidosis caused by propofol infusion: report of one case]Carlos Romero P
Intensive Care Unit, Hospital Clinico Universidad de Chile, Santiago de Chile
Rev Med Chil 136:88-92. 2008..5 mg/kg/h, for 8 hours more. The suspicion of PRIS motivated immediate discontinuation of propofol with rapid correction of lactic acidosis and full recovery of the patient...
- The experimental and clinical pharmacology of propofol, an anesthetic agent with neuroprotective propertiesYoshinori Kotani
Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu 502 8585, Japan
CNS Neurosci Ther 14:95-106. 2008..Recently, EDTA has been reported to exert a neuroprotective effect itself by chelating surplus intracerebral zinc in an ischemia model. This article reviews the neuroprotective effects of propofol and its mechanism of action...
- Reciprocal relationships between general (Propofol) anesthesia and circadian time in ratsEtienne Challet
Department of Neurobiology of Rhythms, Institute of Cellular and Integrative Neurosciences, CNRS UMR7168, University L Pasteur, Strasbourg, France
Neuropsychopharmacology 32:728-35. 2007..Anesthesia-induced hypothermia was not correlated with the phase-shifting effects of propofol anesthesia. From our results, anesthesia itself can reset circadian timing, and acts as a synchronizing cue for the circadian clock...
- Remifentanil vs fentanyl with a target controlled propofol infusion in patients undergoing craniotomy for supratentorial lesionsA Del Gaudio
Department of Anaesthesia and Intensive Care IRCCS H Casa Sollievo della Sofferenza, S Giovanni Rotondo, Foggia, Italy
Minerva Anestesiol 72:309-19. 2006..This study compared the use of remifentanil with that of fentanyl during elective supratentorial craniotomy in a target controlled infusion (TCI)-propofol anesthesia regimen and evaluated the quality of recovery from anesthesia...
- Propofol and thiopental attenuate adenosine triphosphate-sensitive potassium channel relaxation in pulmonary veinsWoon Seok Roh
Center for Anesthesiology Research, NE63, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
Am J Physiol Lung Cell Mol Physiol 291:L636-43. 2006..We investigated the cellular mechanisms by which the intravenous anesthetics propofol and thiopental alter adenosine triphosphate-sensitive potassium (KATP+) channel relaxation in ..
- [Lactic acidosis associated with propofol during general anaesthesia for neurosurgery]J Bordes
Departement d Anesthesie Reanimation, HIA Sainte Anne, Boulevard Sainte Anne, 83800 Toulon, France
Ann Fr Anesth Reanim 27:261-4. 2008..Lactic acidosis could be an early marker of PRIS. We report here a case of very early lactic acidosis in a 66-year-old-man receiving propofol during a neurosurgery. The outcome was good after discontinuation of propofol...
- Propofol infusion syndrome in a patient with sepsisJ J De Waele
Intensive Care Unit, Ghent University Hospital, Belgium
Anaesth Intensive Care 34:676-7. 2006..We present a case of a septic patient without neurological illness who developed propofol infusion syndrome...
- Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anestheticsM D Krasowski
Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
Neuropharmacology 41:952-64. 2001..This suggests that mutation of M286 in the GABA(A) beta(2) subunit alters the dimensions of a 'binding pocket' for propofol and related alkylphenol general anesthetics...
- Enhanced visual memory effect for negative versus positive emotional content is potentiated at sub-anaesthetic concentrations of thiopentalK O Pryor
Department of Anesthesiology, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
Br J Anaesth 93:348-55. 2004..It is not known how gamma aminobutyric acid (GABA)ergic drugs affect the processes involved in memory modulation. This study investigates whether memory for negative emotional stimuli is more refractory to the effects of GABAergic drugs...
- General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunitRachel Jurd
Institute of Pharmacology and Toxicology, University of Zurich, CH 8057 Zurich, Switzerland
FASEB J 17:250-2. 2003..In these mice, the suppression of noxious-evoked movements in response to the intravenous anesthetics etomidate and propofol is completely abolished, while only slightly decreased with the volatile ..
- The anesthetic mechanism of urethane: the effects on neurotransmitter-gated ion channelsKoji Hara
Waggoner Center for Alcohol and Addiction Research and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712 1095, USA
Anesth Analg 94:313-8, table of contents. 2002..Our results also suggest that small changes in multiple receptor systems can produce anesthesia...
- Effects of volatile and intravenous anesthetics on the uptake of GABA, glutamate and dopamine by their transporters heterologously expressed in COS cells and in rat brain synaptosomesM Sugimura
Department of Anesthesiology, Faculty of Dentistry, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Japan
Toxicol Lett 123:69-76. 2001..The present study examined the effects of volatile and intravenous anesthetics on the uptake of GABA, glutamate and dopamine in COS cells heterologously expressing the transporters for ..
- Intravenous anesthetics inhibit nonadrenergic noncholinergic lower esophageal sphincter relaxation via nitric oxide-cyclic guanosine monophosphate pathway modulation in rabbitsA Kohjitani
Department of Dental Anesthesiology, Okayama University School of Dentistry, Japan
Anesthesiology 95:176-83. 2001..Nonadrenergic noncholinergic (NANC) nerves have important roles in the regulation of the lower esophageal sphincter (LES) motility and function. The effects of thiopental, ketamine, and midazolam on NANC LES relaxation were investigated...
- Major role for tonic GABAA conductances in anesthetic suppression of intrinsic neuronal excitabilityMark C Bieda
Neuroscience Program and Department of Anesthesia, Stanford University, SUMC 288 MC5117, Stanford, CA 94305, USA
J Neurophysiol 92:1658-67. 2004....
- General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor but not with lipid solubilityM D Krasowski
Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois, USA
J Pharmacol Exp Ther 297:338-51. 2001..These data suggest steric constraints for the binding site for propofol on the GABA(A) receptor...
- Propofol suppresses the cortical somatosensory evoked potential in ratsHelene G Logginidou
Department of Anesthesiology, Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, USA
Anesth Analg 97:1784-8. 2003..6 +/- 3.4 microg/mL (10.8 50% effective concentration), a measurable response was present in 44.5% of rats. These results suggest that even at large doses, propofol and remifentanil provide adequate conditions for SEP monitoring...
- Does anaesthesia care affect the outcome following craniotomy?Kate Leslie
Staff Anaesthetist, Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Australia
J Clin Neurosci 9:231-6. 2002
- Neuropharmacology of GHB discriminationWouter Koek; Fiscal Year: 2010..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
- Discriminative Stimulus Effects of Alcohol in MiceWouter Koek; Fiscal Year: 2007..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. [unreadable] [unreadable] [unreadable]..
- NITROXIDERGIC CEREBROVASCULAR TONE DURING ANESTHESIAShailendra Joshi; Fiscal Year: 2005..abstract_text> ..
- PHARMACOLOGY OF ANESTHETICS IN HEMORRHAGIC SHOCKKen Johnson; Fiscal Year: 2002..The absence of a scientific foundation to guide the rational selection and administration of intravenous anesthetics during shock represents a huge gap in the anesthesia clinical pharmacology literature...
- ANESTHETIC MECHANISMS AND GABA-A RECEPTOR STRUCTUREMYLES AKABAS; Fiscal Year: 2001..Many drugs used in the induction of general anesthesia, including benzodiazepines, volatile and intravenous anesthetics and barbiturates potentiate GABA-induced currents...
- ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONSIgor Kissin; Fiscal Year: 2001In the initial project (85-88), we demonstrated that a combination of intravenous anesthetics may provide different outcomes (addition, synergism, or antagonism) regarding different components of anesthesia (e.g...
- GENERAL ANESTHETICS AND CLONED VOLTAGE-GATED CHANNELSANA CORREA; Fiscal Year: 2000..The roles played by auxiliary subunits will be investigated. (4) To initiate studies on the action of intravenous anesthetics on voltage-gated ion channels...
- ORGAN PROTECTION: ROLE OF ANESTHETICSJOHN TINKER; Fiscal Year: 1980..We intend to test large dose fentanyl, large dose morphine, and diazepam intravenous anesthetics using this same model...
- AUTONOMIC AND VASCULAR EFFECTS OF ANESTHETICS IN HUMANSThomas Ebert; Fiscal Year: 2000..L-NMMA) to block the synthesis of EDRF/NO before and during administration of either volatile or intravenous anesthetics. Additional studies will be carried out to determine if volatile anesthetics alter either arterial or ..
- BRAIN AND SPINAL CORD CONTRIBUTIONS TO ANESTHETIC ACTIONJOSEPH ANTOGNINI; Fiscal Year: 2005..This information will aid the development of newer and safer anesthetics, as well as lead to clinically useful means of modulating the neurotransmitter systems that are themselves modulated by anesthetics. ..
- ANESTHETIC EFFECTS ON SENSORIMOTOR INTEGRATIONJOSEPH ANTOGNINI; Fiscal Year: 2009..Understanding how and where anesthetics act will eventually lead to the development of better and safer anesthetics, thereby decreasing peri-operative morbidity and mortality and improving public health. ..
- The Effect of Sedation on Restorative SleepAvery Tung; Fiscal Year: 2005..Knowledge from this proposal will provide scientific insight into the relationships between anesthesia and sleep, and may lead to more effective clinical use of ICU sedatives. ..
- COMPARING THREE ELECTRODE PLACEMENTS TO OPTIMIZE ECTKeith Rasmussen; Fiscal Year: 2005..The results of this study will promote more effective and safer treatment of the most severely ill depressed patients. ..
- Anesthetic Binding Sites on Three-Helix Bundle ProteinsJonas Johansson; Fiscal Year: 2006..A precise structural description of the anesthetic binding site on this model system will allow a focused search of the Protein Data Bank for potential binding sites on existing- and future entries. ..
- Microarray analysis of neuronal ischemic preconditioningPiyush Patel; Fiscal Year: 2007..A substantial benefit of the research will be the identification of novel therapeutic targets upon which future drug development can be based. ..
- CRH Antagonists for Treatment of Drug AbuseJames Woods; Fiscal Year: 2005..This may provide information about the etiology of drug abuse, as well as data on the potential treatment of drug abuse in normal, or particularly, in stressed individuals. ..
- The Role of the Amygdala in Anesthetic-Induced AmnesiaMICHAEL ALKIRE; Fiscal Year: 2006..abstract_text> ..
- SECOND INTERNATIONAL CONFERENCE PEDIATRIC CARDIAC DEVICEAkif Undar; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- Dynamic Signal Processing Analyses of Neural PlasticityEmery Brown; Fiscal Year: 2006..abstract_text> ..
- NARCOTIC DRUG AND OPIOID PEPTIDE BASIC RESEARCH PROJECTJames Woods; Fiscal Year: 2006..abstract_text> ..
- Functional Analysis of GABAerglc Sedative/AnxiolyticsNANCY ATOR; Fiscal Year: 2007..abstract_text> ..
- Neurophysiologic Development Responses to SurgeryDOUGLAS RIRIE; Fiscal Year: 2007..Through this and future studies which come from this data and training, improvement in understanding will hopefully lead to improved pain therapy that is developmentally appropriate. ..
- STATISTICAL ANALYSIS OF HIPPOCAMPAL INFORMATION ENCODINGEmery Brown; Fiscal Year: 2008..More accurate characterizations of neuronal dynamics may also lead to more physiologically-sound approaches to creating machine-brain interfaces and designing neural prosthetic devices. ..
- Pharmacotherapy of Cannabinoid Withdrawal: Pre-Clinical StudiesLance R McMahon; Fiscal Year: 2010..Collectively, these specific aims provide a framework for developing novel pharmacotherapies of marijuana withdrawal that could markedly decrease marijuana use and dependence. ..
- Ischemic Stroke Treatment with Microbubbles, a Novel Clot Lysis TherapeuticWilliam C Culp; Fiscal Year: 2010..Our proposed pilot study will determine which of these treatments is most successful, and future studies will further explore that treatment. (End of Abstract) ..
- Behavioral and Pharmacological Analysis of Drugs of AbuseJERROLD WINTER; Fiscal Year: 2008..This likelihood coupled with continued interest in the therapeutic use of agents such as psilocybin makes a detailed pharmacological assessment of these drugs of utmost importance. ..
- VOLATILE ANESTHETICS AND RESPIRATORY NEUROTRANSMISSIONEckehard Stuth; Fiscal Year: 2009....
- Development of Esterases for the Treatment of Cocaine Overdose and AbuseJames Woods; Fiscal Year: 2009..These procedures are designed to prolong the enzyme's duration of action with the hopeful outcome that some insight will be obtained into how to make this substance useful in the long-term treatment of cocaine abuse. ..
- Dynamic Analyses of Learning in Behavioral ExperimentsEmery Brown; Fiscal Year: 2009....
- FOURTH INTERNATIONAL CONFERENCE ON PEDIATRIC CARDIAC DEVICESAkif Undar; Fiscal Year: 2008..This will be the only national/international conference to focus solely on pediatric cardiac patients. (End of Abstract) [unreadable] [unreadable] [unreadable]..
- SITES AND MECHANISMS OF INHALED ANESTHETIC ACTIONSEDMOND EGER; Fiscal Year: 2008..abstract_text> ..
- Genes Underlying the Response to Inhaled AnestheticsJames Sonner; Fiscal Year: 2008....
- Drug discrimination and THC withdrawal in monkeysLANCE MCMAHON; Fiscal Year: 2005..abstract_text> ..
- Increasing Functional Liver Mass in Health and DiseaseLeonidas Koniaris; Fiscal Year: 2005..2) Determine the extent to which and mechanisms by which co-administrating HCF and Follistatin along with IL-6 facilitates the liver growth response and reduces IL-6 associated toxicity. ..
- Cerebal Ischemia During Anesthesia and SurgeryPiyush Patel; Fiscal Year: 2004..The long term goals of the research are to prevent the occurrence of isehemic brain injury in patients undergoing anesthesia and surgery. ..
- Ethanol and synaptic plasticity in the cerebellumCHIMING HUANG; Fiscal Year: 2004..To ensure that the observed synaptic reorganization/loss and functional deficit occur without significant cell loss, we will employ unbiased stereology to evaluate the number of granule cells and Purkinje cells. ..
- MODERATE ALCOHOL CONSUMPTION AND HDLWILLEM DEVILLIERS; Fiscal Year: 2003..This will be done by measuring the bioactivity of paraoxonase and determining the ability of HDL from human subjects exposed to alcohol to protect against macrophage-mediated LDL. ..
- ANESHETIC MODULATION OF NATIVE NICOTINIC RECEPTORSPamela Flood; Fiscal Year: 2003..The resulting information will provide understanding of the molecular mechanism underlying one of the anesthetic effects that limit anesthetic safety. ..
- EVALUATION OF PROTEIN BASED MEDICATIONS AGAINST COCAINEJames Woods; Fiscal Year: 2003..Studies in which the ability of BChE and Mab 15A10 to produce increases in the cocaine metabolite, egconine methyl ester are planned to demonstrate that both of these medications increase the rate of cocaine metabolism. ..
- Developmental Studies of Sound Localization MechanismsDANIEL TOLLIN; Fiscal Year: 2003....
- Biobehavioral Heterogeneity of Crack Cocaine DependenceLeslie Prichep; Fiscal Year: 2003..Application of new mathematical algorithms will permit identification of the most probable neuroanatomical sources generating the QEEG, which may improve understanding of underlying mechanisms and help target new medications. ..
- Exacerbation of Alzheimer's Disease by Nitrous OxideW Kofke; Fiscal Year: 2003..Moreover, observation of a protective effect may result in discovery of an easily implemented preventative drug therapy for AD. ..
- CD36 AND HEPATIC STELLATE CELL ACTIVATIONWILLEM DEVILLIERS; Fiscal Year: 2002..We will determine whether spontaneously hypertensive rats and CD36-deficient mice are resistant to the development of hepatic fibrosis. ..
- BCHE as a Cocaine AntagonistJames Woods; Fiscal Year: 2002..The possibility that human BChE can eventually be used as a safe and effective treatment of cocaine abuse and toxicity is being explored through these studies. ..
- STATISTICAL ANALYSIS OF HUMAN CIRCADIAN RHYTHMSEmery Brown; Fiscal Year: 2001....
- SENESCENCE ALTERS SYMPATHETIC REGULATION TO HEAT STRESSMICHAEL KENNEY; Fiscal Year: 2004..The proposed studies will, for the first time, advance the hypothesis that the working strategies employed by sympathetic neural circuits to respond to heat stress are modified by aging. ..
- Oral Care and Respiratory Pathogen ColonizationOzan Akca; Fiscal Year: 2004..Reducing respiratory pathogen colonization in the mouth could significantly reduce the morbidity and cost of VAP. ..
- Stress, Rearing, and Ethanol Reinforcement in MonkeysJames Woods; Fiscal Year: 2005..These studies will contribute to a better understanding of the biological basis of alcoholism, which is a first step toward the development of effective pharmacotherapeutic interventions. ..
- Strategies for Improving Sedation Outcomes in the ICUJOHN KRESS; Fiscal Year: 2005..abstract_text> ..
- PEDIATRIC MECHANICAL CIRCULATORY SUPPORT SYSTEMSAkif Undar; Fiscal Year: 2005..The manuscripts from all of the contributors including key note, invited, slide and poster presenters will be peer-reviewed and will be published in the November-December 2005 issue of the ASAIO Journal. ..
- The Role of GDF-15 in Organ InjuryLeonidas Koniaris; Fiscal Year: 2005..The completion of this mentored research training will further the candidate?s goal of applying bench-derived scientific discovery to the treatment of surgical disease as an independent investigator. ..
- BEHAVIORAL & PHARMACOLOGICAL ANALYSIS OF DRUGS OF ABUSEJERROLD WINTER; Fiscal Year: 2005..abstract_text> ..
- Sympathetic-Immune Interface: Central Sites & FunctionMICHAEL KENNEY; Fiscal Year: 2005..Ultimately, these findings may allow for the design of intervention strategies in immune regulation fostering robust and appropriate communication between the immune and nervous systems. ..
- Pain Assessment in Cognitively Impaired ChildrenShobha Malviya; Fiscal Year: 2005..A reliable and valid pain assessment tool is critical to facilitate our future study of pain management strategies in these children. ..
- Statistical Modeling of Functional MRI SignalsEmery Brown; Fiscal Year: 2004..abstract_text> ..
- Novel direct vago-vagal recording of i.v. ghrelin actionDavid Adelson; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Sodium Channel Blockers as Inhibitors of Prostate CancerMilton Brown; Fiscal Year: 2008..abstract_text> ..
- Gastric Tube Placement in Young ChildrenMarsha Ellett; Fiscal Year: 2008..Results from this study will increase the safety of using gastric tubes in young children. ..
- BLOOD PRESSURE CONTROL BY FOREBRAIN & BRAINSTEM NEURONSSUSAN BARMAN; Fiscal Year: 2008..unreadable] [unreadable]..