Genomes and Genes
Summary: Gases or volatile liquids that vary in the rate at which they induce anesthesia; potency; the degree of circulation, respiratory, or neuromuscular depression they produce; and analgesic effects. Inhalation anesthetics have advantages over intravenous agents in that the depth of anesthesia can be changed rapidly by altering the inhaled concentration. Because of their rapid elimination, any postoperative respiratory depression is of relatively short duration. (From AMA Drug Evaluations Annual, 1994, p173)
Publications218 found, 100 shown here
- Inhalation anesthetics induce apoptosis in normal peripheral lymphocytes in vitroH Matsuoka
Department of Anesthesiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
Anesthesiology 95:1467-72. 2001..hypothesized that perioperative lymphocytopenia is partially caused by apoptosis of lymphocytes induced by inhalation anesthetics. Therefore, they evaluated whether sevoflurane and isoflurane induce apoptosis of normal peripheral ..
- Influence of inhalation anesthesia assessed by comprehensive gene expression profilingAtsuhiro Sakamoto
Department of Anesthesiology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
Gene 356:39-48. 2005..Our findings provide the first assessment for the influence of inhalation anesthesia by approaches of experimental biology and genome science...
- Validation of several types of noxious stimuli for use in determining the minimum alveolar concentration for inhalation anesthetics in dogs and rabbitsAlexander Valverde
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
Am J Vet Res 64:957-62. 2003..To compare 3 types of noxious stimuli applied to various anatomic areas of anesthetized dogs and rabbits for determination of the minimum alveolar concentration (MAC)...
- Toward a unified theory of narcosis: brain imaging evidence for a thalamocortical switch as the neurophysiologic basis of anesthetic-induced unconsciousnessM T Alkire
Department of Anesthesiology, University of California at Irvine, Irvine, California 92697, USA
Conscious Cogn 9:370-86. 2000....
- The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the alpha(2) adrenergic sedative dexmedetomidine, and cannabinoid agonistsAnni Maija Linden
Institute of Biomedicine, Pharmacology, University of Helsinki, P O Box 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
J Pharmacol Exp Ther 317:615-26. 2006b>Inhalation anesthetics activate and cannabinoid agonists inhibit TWIK-related acid-sensitive K(+) channels (TASK)-1 two-pore domain leak K(+) channels in vitro...
- Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humansKaike K Kaisti
Department of Anesthesiology, Turku University Hospital, Finland
Anesthesiology 99:603-13. 2003....
- Inhalation anesthetics: a reviewG Torri
Department of Anesthesiology, S Raffaele University, Milan, Italy
Minerva Anestesiol 76:215-28. 2010..The different mechanisms of action of the inhalation agents and the evolution from a unitary theory of inhaled anesthetics to a multiple mechanism concept are presented...
- Effects of inhalation anesthetics halothane, sevoflurane, and isoflurane on human cell linesSlavica Kvolik
Department of Anesthesiology, Clinical Hospital Osijek, J Huttlera 4, 31000 Osijek, Croatia
Life Sci 77:2369-83. 2005..4% (p=0.007). A DNA fragmentation was observed in Caco-2 and MIA PaCa-2 cells. Exposition of phosphatidylserine on outer lipid bilayer plasma membrane of tumor cell treated by halothane proved apoptosis as mode of cell death...
- Effects of halothane and propofol on excitatory and inhibitory synaptic transmission in rat cortical neuronsAkira Kitamura
Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
J Pharmacol Exp Ther 304:162-71. 2003..The additional calcium-dependent inhibition of mIPSC and mEPSC frequency by halothane (but not propofol) suggests a more general mechanism by this anesthetic on presynaptic transmitter release...
- Isoflurane disrupts central pattern generator activity and coordination in the lamprey isolated spinal cordSteven L Jinks
Department of Anesthesiology and Pain Medicine, University of California School of Medicine, Davis, CA 95616, USA
Anesthesiology 103:567-75. 2005..However, it is unclear whether volatile anesthetics depress locomotor interneurons comprising central pattern generators or disrupt intersegmental central pattern generator coordination...
- Cholinergic reversal of isoflurane anesthesia in rats as measured by cross-approximate entropy of the electroencephalogramAnthony G Hudetz
Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
Anesthesiology 99:1125-31. 2003..The effect of cholinergic agents on C-ApEn has not been examined. Here, the authors test the hypothesis that cholinergic activation reverses the effect of isoflurane anesthesia on C-ApEn...
- Isoflurane depresses glutamate release by reducing neuronal excitability at the Drosophila neuromuscular junctionDavid J Sandstrom
Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health MSC 4034, Bethesda, MD 20892, USA
J Physiol 558:489-502. 2004..These results provide a cellular context for ongoing genetic and neurophysiological analyses of volatile anaesthetic action in Drosophila, and suggest candidate anaesthetic target molecules...
- Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isofluraneMark Liao
Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
Anesth Analg 101:412-8, table of contents. 2005....
- Long-term exposure to local but not inhalation anesthetics affects neurite regeneration and synapse formation between identified lymnaea neuronsShin Onizuka
Calgary Brain Institute, Faculty of Medicine, University of Calgary, and Department of Anesthesiology, Miyazaki Medical College, University of Miyazaki, Japan
Anesthesiology 102:353-63. 2005..Because synaptic transmission recovers rapidly from various inhalation anesthetics, it is generally assumed that their effects on nerve regeneration and synapse formation that precede ..
- Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isofluraneM D Krasowski
Department of Committee on Neurobiology, University of Chicago, Chicago, Illinois 60637, USA
Mol Pharmacol 53:530-8. 1998..These data indicate that the receptor structural requirements for positive modulation by volatile and intravenous general anesthetics may be quite distinct...
- Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in ratsDeborah J Culley
Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
Anesthesiology 100:309-14. 2004..This experiment was designed to test the hypothesis that learning of new information is particularly susceptible to prolonged disruption after general anesthesia...
- Spatio-temporal characteristics of low-frequency BOLD signal fluctuations in isoflurane-anesthetized rat brainSridhar S Kannurpatti
Department of Radiology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
Neuroimage 40:1738-47. 2008..Also, a high inter-hemispheric synchrony combined with different phase characteristics of the low-frequency BOLD fluctuations particularly in the hippocampus relative to the cortex emphasizes distinct functional networks...
- Isoflurane blocks synaptic plasticity in the mouse hippocampusW Simon
Max-Planck-Institute of Psychiatry, Munich, Germany
Anesthesiology 94:1058-65. 2001..An impairment of these processes may be a cause for the transient loss of recall and cognitive impairment after anesthesia in juvenile and adult brains...
- A new device to reduce the consumption of a halogenated anaesthetic agentM Enlund
University Department of Anaesthesia and Intensive Care, Samariterhemmets Sjukhus Uppsala, Sweden
Anaesthesia 56:429-32. 2001..2 (3.0) ml x MAC-hour(-1) with the new device (p < 0.05). This corresponded to a 40% saving in the consumption of isoflurane. The amount of isoflurane that was scavenged to the atmosphere was reduced by an average of 55%...
- AnaConDa reflection filter: bench and patient evaluation of safety and volatile anesthetic conservationJerôme Berton
Anesthesia and Intensive Care Unit, Angers Teaching Hospital, Angers, France
Anesth Analg 104:130-4. 2007..The AnaConDa filter permits administration of volatile anesthetic without the use of an anesthesia machine. It is intended for use in the intensive care unit...
- Up-regulation of hypoxia inducible factor 1alpha by isoflurane in Hep3B cellsQi Fang Li
Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dongfang Road, Shanghai 200127, China
Anesthesiology 105:1211-9. 2006..Little is known about the extent to which induction of HIF-1alpha is affected by isoflurane...
- Isoflurane disrupts anterio-posterior phase synchronization of flash-induced field potentials in the ratOlga A Imas
Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA
Neurosci Lett 402:216-21. 2006..These findings suggest that a disruption of long-range anterio-posterior rather than local anterior synchronization of neuronal activity precedes the anesthetic-induced loss of consciousness...
- Effect of volatile anesthetics on interhemispheric EEG cross-approximate entropy in the ratAnthony G Hudetz
Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Brain Res 954:123-31. 2002..The results suggest that C-ApEn of bihemispheric EEG is a sensitive, agent-specific correlate of anesthetics' central effect...
- Isoflurane pretreatment inhibits lipopolysaccharide-induced inflammation in ratsRoman V Plachinta
Department of Anesthesiology University of Virginia Health System, Charlottesville, Virginia 22908 0710, USA
Anesthesiology 98:89-95. 2003....
- Mechanism of hepatic heme oxygenase-1 induction by isofluraneAlexander Hoetzel
Department of Anesthesiology and Critical Care Medicine, University of Freiburg, Germany
Anesthesiology 104:101-9. 2006..Because the activating cascade remained unclear, it was the aim of this study to identify the underlying mechanism of this effect...
- The anesthetic conserving device compared with conventional circle system used under different flow conditions for inhaled anesthesiaAugusto Tempia
Istituto di Anestesia e Rianimazione, Ospedale San Luigi di Orbassano, Orbassano TO, Italy
Anesth Analg 96:1056-61, table of contents. 2003..Respiratory gas humidification was always adequate. Sevoflurane ambient concentration with the ACD was 1-70 ppb. The ACD is a valid and simple alternative to low-flow systems...
- Isoflurane and propofol inhibit voltage-gated sodium channels in isolated rat neurohypophysial nerve terminalsWei Ouyang
Department of Anesthesiology, Box 50, LC 203, 525 E 68th St, Weill Medical College of Cornell University, New York, NY 10021, USA
Mol Pharmacol 64:373-81. 2003..Inhibition of voltage-gated Na+ channels may contribute to the presynaptic effects of general anesthetics on nerve terminal excitability and neurotransmitter release...
- Isoflurane preconditioning decreases glutamate receptor overactivation-induced Purkinje neuronal injury in rat cerebellar slicesShuqiu Zheng
Department of Anesthesiology, University of Virginia Health System, One Hospital Drive, P O Box 800710, Charlottesville, VA 22908 0710, USA
Brain Res 1054:143-51. 2005..Thus, isoflurane preconditioning reduced glutamate receptor overstimulation-induced neuronal injury/death. This neuroprotection may be PKC- and NOS-dependent...
- Isoflurane inhibits transmitter release and the presynaptic action potentialXin Sheng Wu
Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri, USA
Anesthesiology 100:663-70. 2004..However, the extent of the presynaptic contribution has not been quantitatively studied. Furthermore, the mechanism underlying the presynaptic contribution remains unclear...
- Direct cerebral vasodilatory effects of sevoflurane and isofluraneB F Matta
Department of Anaesthesia, Addenbrooke s Hospital, Cambridge, United Kingdom
Anesthesiology 91:677-80. 1999..This study compared the direct cerebral vasodilatory actions of 0.5 and 1.5 minimum alveolar concentration (MAC) sevoflurane and isoflurane during an propofol-induced isoelectric electroencephalogram...
- Up-regulation of heme oxygenase-1 by isoflurane preconditioning during tolerance against neuronal injury induced by oxygen glucose deprivationQifang Li
Department of Anesthesiology, Shanghai Ninth People s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
Acta Biochim Biophys Sin (Shanghai) 40:803-10. 2008..These findings indicated that the neuroprotective role of isoflurane preconditioning against OGD-induced injury might be associated with its role in up-regulating HO-1 in ischemic neurons...
- A review of the safety of 50% nitrous oxide/oxygen in conscious sedationValérie Collado
Univ Clermont1, EA 3847, Faculté d Odontologie, 11 bvd Charles de Gaulle, F 63000 Clermont Ferrand, France
Expert Opin Drug Saf 6:559-71. 2007..No analysis of the effect of the method of administration was possible, nor could conclusions be drawn relating to the risk of occupational exposure...
- Inhalational or intravenous anesthetics for craniotomies? Pro inhalationalKristin Engelhard
Klinik fur Anasthesiologie, Johannes Gutenberg Universitat, Mainz, Germany
Curr Opin Anaesthesiol 19:504-8. 2006....
- Cine-MRI assessment of cardiac function in mice anesthetized with ketamine/xylazine and isofluraneF Kober
Centre de Resonance Magnetique Biologique et Medicale, Faculte de Medecine, 27 Bd Jean Moulin, 13005, Marseille, France
MAGMA 17:157-61. 2004....
- [Occupational exposure to inhalation anesthetics: 10 years of measurements at hospitals in Puglia]F Cassano
Dipartimento di Medicina Interna e Medicina Pubblica, Sezione di Medicina del Lavoro, Universita degli Studi di Bari, Centro di Igiene Ambientale, Fondazione S Maugeri, Bari
G Ital Med Lav Ergon 25:279-81. 2003..Finally, the Authors prove the utility of the graphic representation of the measurements, conduced utilising dedicated instrumentation...
- Impaired acquisition of spatial memory 2 weeks after isoflurane and isoflurane-nitrous oxide anesthesia in aged ratsDeborah J Culley
Department of Anesthesiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Anesth Analg 99:1393-7; table of contents. 2004..05). There were no differences in total number of errors (P < or = 0.06). Thus, spatial memory is impaired for 2 wk after general anesthesia in aged rats independent of whether nitrous oxide is used...
- Desflurane selectively suppresses long-latency cortical neuronal response to flash in the ratAnthony G Hudetz
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Anesthesiology 111:231-9. 2009..The authors studied the effect of desflurane on resting and visual evoked unit activity in rat visual cortex in vivo...
- Inhalational anaesthetics in the ICU: theory and practice of inhalational sedation in the ICU, economics, risk-benefitAndreas Meiser
Klinik fur Anaesthesiologie, St Josef Hospital, Ruhr Universitat Bochum, Gudrunstr 56, 44791 Bochum, Germany
Best Pract Res Clin Anaesthesiol 19:523-38. 2005..The technical prerequisites are explained, and the practice and pitfalls of inhalational ICU sedation in general and when using the AnaConDa are described in detail...
- Prolonged isoflurane sedation of intensive care unit patients with the Anesthetic Conserving DevicePeter V Sackey
Department of Anesthesiology and Intensive Care Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
Crit Care Med 32:2241-6. 2004..To test the efficacy and patient safety of a new method for administering isoflurane for prolonged sedation in the intensive care unit...
- Safety of inhalation of a 50% nitrous oxide/oxygen premix: a prospective survey of 35 828 administrationsPeter Onody
Department of Clinical Research and Development, Air Liquide Santé International, Paris, France
Drug Saf 29:633-40. 2006..This prospective study, conducted in the same conditions imposed for testing a drug, aims to analyse the factors that affect tolerance of the 50% N(2)O/O(2) premix in a wide range of clinical indications...
- Genotoxicity of inhalation anesthetics halothane and isoflurane in human lymphocytes studied in vitro using the comet assayP Jaloszyński
Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60 479, Poznan, Poland
Mutat Res 439:199-206. 1999The alkaline single cell gel electrophoresis (comet) assay was applied to study genotoxic properties of two inhalation anesthetics-halothane and isoflurane-in human peripheral blood lymphocytes (PBL)...
- Population pharmacokinetics of sevoflurane in conjunction with the AnaConDa: toward target-controlled infusion of volatiles into the breathing systemM Enlund
Department of Anesthesia and Intensive Care, Central Hospital, Vasteras, Sweden
Acta Anaesthesiol Scand 52:553-60. 2008..We performed in vitro characterization of the device before developing a population pharmacokinetic model for sevoflurane administration with the AnaConDa, and retrospectively testing its performance (internal validation)...
- The effect of nitrous oxide on cerebral blood flow velocity in children anaesthetised with desfluraneC Karsli
Department of Anaesthesia, University of Toronto, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8
Anaesthesia 58:24-7. 2003..This may be due to a more potent cerebral vasodilatory effect of desflurane in children...
- The sevoflurane saving capacity of a new anaesthetic agent conserving device compared with a low flow circle systemM Enlund
University Department of Anaesthesia and Intensive Care, Uppsala, Sweden
Acta Anaesthesiol Scand 46:506-11. 2002..An anaesthetic agent conserving device (ACD) has been added to a Bain system to approach the agent-saving capacity of a low flow circle system...
- Functional comparison of anaesthetic agents during myocardial ischaemia-reperfusion using pressure-volume loopsD T Andrews
Cardiovascular and Therapeutics Unit, Department of Pharmacology, University of Melbourne, Melbourne, Australia
Br J Anaesth 103:654-64. 2009..Left ventricular (LV) pressure-volume (PV) loops were used to compare the functional effects that accompany the cardioprotection seen with desflurane, sevoflurane, and propofol in a rabbit preparation of coronary ischaemia-reperfusion (IR)...
- General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunitRachel Jurd
Institute of Pharmacology and Toxicology, University of Zurich, CH 8057 Zurich, Switzerland
FASEB J 17:250-2. 2003....
- Circadian gene expression is suppressed during sevoflurane anesthesia and the suppression persists after awakeningKatsuya Kobayashi
Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
Brain Res 1185:1-7. 2007..This suggests that sevoflurane anesthesia may have effects at the molecular level and that these effects are long lasting...
- Cerebral blood volume (CBV) in humans during normo- and hypocapnia: influence of nitrous oxide (N(2)O)P Reinstrup
Department of Anesthsiology, University Hospital, Lund, Sweden
Anesthesiology 95:1079-82. 2001..The aim of the current study was to evaluate the effect of N(2)O on three-dimensional regional and global CBV in humans during normocapnia and hypocapnia...
- Neocortex is the major target of sedative concentrations of volatile anaesthetics: strong depression of firing rates and increase of GABAA receptor-mediated inhibitionHarald Hentschke
Section of Experimental Anaesthesiology, University Clinics of Anaesthesiology, University of Tubingen, Tubingen, Germany
Eur J Neurosci 21:93-102. 2005....
- Isoflurane-induced surgical tolerance mediated only in part by beta3-containing GABA(A) receptorsSachar Lambert
Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Eur J Pharmacol 516:23-7. 2005..At high concentrations isoflurane also immobilizes beta3(N265M) mice, indicating that other targets also mediate immobility. Thus, our findings support a multisite model for the immobilizing action of isoflurane...
- The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivoAnant B Patel
Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 102:5588-93. 2005..The contribution of GABAergic neurons and inhibition to cortical energy metabolism has broad implications for the interpretation of functional imaging signals...
- Comparison of remifentanil and nitrous oxide in labour analgesiaP Volmanen
Department of Anaesthesia and Intensive Care, Lapland Central Hospital, Rovaniemi, Finland
Acta Anaesthesiol Scand 49:453-8. 2005..We compared the efficacy and side-effects of remifentanil with those of nitrous oxide during the first stage of labour...
- [AnaConDa as last resort treatment. Case report of a chronic obstructive pulmonary disease]E A Nickel
Zentrum Anaesthesiologie, Rettungs und Intensivmedizin, Georg August Universitat Gottingen, 37099 Gottingen
Anaesthesist 56:587-91. 2007..Elimination of CO(2) was improved and weaning from controlled ventilation was achieved. After surgical removal of a pulmonary abscess and a total of 78 days of intensive care therapy, the patient was discharged in good health...
- Comparison of electroencephalogram activity and auditory evoked responses during isoflurane and halothane anaesthesia in the ratLuis M Antunes
Comparative Biology Centre, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Vet Anaesth Analg 30:15-23. 2003....
- Cerebrovascular reactivity to carbon dioxide is preserved during hypocapnia in children anesthetized with 1.0 MAC, but not with 1.5 MAC desfluraneIgor A Luginbuehl
Department of Anaesthesia, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Can J Anaesth 50:166-71. 2003..Maintenance of cerebrovascular reactivity to CO(2) (CCO(2)R) is important during neurosurgical anesthesia. This study was designed to determine the effect of different desflurane concentrations on CCO(2)R in children...
- Use of the AnaConDa anaesthetic delivery system to treat life-threatening asthmaH Thomson
Anaesthesia 62:295-6. 2007
- The predictive performance of a pharmacokinetic model for manually adjusted infusion of liquid sevofluorane for use with the Anesthetic-Conserving Device (AnaConDa): a clinical studyJavier F Belda
Anesthesiology and Intensive Care Department, Hospital Clinico Universitario de Valencia, Avenida Blasco Ibanez, 17 46010 Valencia, Spain
Anesth Analg 106:1207-14, table of contents. 2008..We evaluated the predictive performance of a simple manually adjusted pump infusion scheme, for infusion of liquid sevoflurane to the AnaConDa...
- Ambient isoflurane pollution and isoflurane consumption during intensive care unit sedation with the Anesthetic Conserving DevicePeter V Sackey
Department of Anesthesiology and Intensive Care, Karolinska University Hospital Solna, Stockholm, Sweden
Crit Care Med 33:585-90. 2005..To examine ambient isoflurane pollution, scavenging efficacy, and isoflurane consumption using the Anesthetic Conserving Device (ACD) for prolonged isoflurane sedation in the intensive care unit...
- Volatile anesthetic action in a computational model of the thalamic reticular nucleusAllan Gottschalk
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Anesthesiology 110:996-1010. 2009..Motivated by the role of the thalamus in consciousness and sensory processing, a computational model of the thalamic reticular nucleus was used to determine the collective impact on model behavior of VA action at multiple sites...
- Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: 4-aminopyridine-evoked releaseRobert I Westphalen
Department of Anesthesiology LC 203, Weill Medical College of Cornell University, Box 50, 1300 York Avenue, New York, NY 10021, USA
J Pharmacol Exp Ther 316:216-23. 2006....
- Tolerability of an equimolar mix of nitrous oxide and oxygen during painful procedures in very elderly patientsCarole Bauer
Geriatrics Department, Georges Pompidou European Hospital, Paris, France
Drugs Aging 24:501-7. 2007..In this article, we investigate the tolerability of this equimolar mix in very elderly patients undergoing painful procedures...
- Comparison of anesthetic depth indexes based on thalamocortical local field potentials in ratsAura Silva
Centro de Ciência Animal e Veterinária, Universidade de Tras os Montes e Alto Douro, Vila Real, Portugal
Anesthesiology 112:355-63. 2010....
- A comparative study of sevoflurane sedation with nitrous oxide sedation for dental surgeryC Y Wang
Department of Anaesthesia, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
Int J Oral Maxillofac Surg 31:506-10. 2002..There was high acceptance of both methods and the patients rated the technique as equally satisfactory. We conclude that inhalation sedation with sevoflurane is a suitable alternative method to nitrous oxide sedation...
- A novel method for determining the blood/gas partition coefficients of inhalation anesthetics to calculate the percentage of loss at different temperaturesN C Yang
Department of Anesthesiology, Taichung Veterans General Hospital, Taichung, Taiwan
J Anal Toxicol 28:122-7. 2004The loss by blood/gas (lambda) partition of inhalation anesthetics can be estimated by an equation for the percentage of loss...
- The electrocortical effects of enflurane: experiment and theoryJames W Sleigh
Department of Anaesthesiology, Waikato Clinical School, University of Auckland, Auckland, New Zealand
Anesth Analg 109:1253-62. 2009..In this study, we compared a theoretical computer model of this activity with real local field potential (LFP) data obtained from anesthetized rats...
- A randomized crossover comparison of the effects of propofol and sevoflurane on cerebral hemodynamics during carotid endarterectomyTimothy J McCulloch
Department of Anaesthetics, University of Sydney, Sydney, and Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
Anesthesiology 106:56-64. 2007..Vasodilation is expected to increase blood flow, reduce ICAP, and reduce apparent zero flow pressure...
- TASK-3 knockout mice exhibit exaggerated nocturnal activity, impairments in cognitive functions, and reduced sensitivity to inhalation anestheticsAnni Maija Linden
Institute of Biomedicine, Pharmacology, University of Helsinki, POB 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
J Pharmacol Exp Ther 323:924-34. 2007..Overall, our results suggest important contributions of TASK-3 channels in the neuronal circuits regulating circadian rhythms, cognitive functions, and mediating specific pharmacological effects...
- Effects of isoflurane and xenon on Ba2+-currents mediated by N-type calcium channelsI L White
Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Campus, 369 Fulham Road, London SW10 9NH, UK
Br J Anaesth 94:784-90. 2005..N-type calcium channels are a putative pre-synaptic target for these agents. We tested whether N-type calcium channels were sensitive to isoflurane and xenon and whether there was any stereoselectivity in the effect of isoflurane...
- Hemodynamic and catecholamine response to a rapid increase in isoflurane or sevoflurane concentration during a maintenance phase of anesthesia in humansTomoki Nishiyama
Department of Anesthesiology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
J Anesth 19:213-7. 2005..The purpose of this study was to compare hemodynamic and catecholamine changes due to a sudden increase in inhalation anesthetic concentrations (isoflurane and sevoflurane) during surgery...
- Local cerebral blood flow, local cerebral glucose utilization, and flow-metabolism coupling during sevoflurane versus isoflurane anesthesia in ratsC Lenz
Department of Anesthesiology, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany
Anesthesiology 89:1480-8. 1998..Compared to isoflurane, knowledge of local cerebral glucose utilization (LCGU) and local cerebral blood flow (LCBF) during sevoflurane anesthesia is limited...
- Approximate entropy as an electroencephalographic measure of anesthetic drug effect during desflurane anesthesiaJ Bruhn
Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Germany
Anesthesiology 92:715-26. 2000..The authors investigated the dose-response relation of the EEG approximate entropy during desflurane anesthesia in comparison with spectral edge frequency 95, median frequency, and bispectral index...
- Volatile anesthetics depress glutamate transmission via presynaptic actionsM B Maclver
Department of Anesthesia, Stanford University School of Medicine, California, USA
Anesthesiology 85:823-34. 1996..Recent evidence for a presynaptic depression of glutamate release produced by volatile anesthetics prompted the current study of isoflurane and halothane effects on glutamate-mediated transmission in the mammalian central nervous system...
- A prospective multicentric trial for effectiveness and tolerance of a N2O/O2 premix used as a sedative drugMartine Hennequin
J Clin Psychopharmacol 24:552-4. 2004
- Propofol: relation between brain concentrations, electroencephalogram, middle cerebral artery blood flow velocity, and cerebral oxygen extraction during induction of anesthesiaGuy L Ludbrook
Department of Anaesthesia and Intensive Care, Royal Adelaide Hospital, Adelaide University, North Terrace, Adelaide, South Australia 5000, Australia
Anesthesiology 97:1363-70. 2002..This study measured the brain uptake of propofol in humans and the simultaneous effects on electroencephalography, cerebral blood flow velocity (V(mca)), and cerebral oxygen extraction...
- The effects of nitrous oxide and oxygen on transient hyperemic response in human volunteersK J Girling
University Department of Anaesthesia and Intensive Care, Queen s Medical Centre and City Hospital NHS Trust, Nottingham, United Kingdom
Anesth Analg 89:175-80. 1999..5+/-0.2 to 1.2+/-0.1) and the SA (from 1.0+/-0.1 to 0.8+/-0.1) (P<0.05 for all). We conclude that breathing 50% nitrous oxide in oxygen results in both a significant increase in MCA FV and impairment of transient hyperemic response...
- Positron emission tomography study of regional cerebral metabolism in humans during isoflurane anesthesiaM T Alkire
Department of Anesthesiology, University of California Irvine Medical Center, Orange 92668, USA
Anesthesiology 86:549-57. 1997..To examine this issue, the authors studied the effects of isoflurane anesthesia on human cerebral glucose metabolism using positron emission tomography (PET)...
- Three cases of PICU sedation with isoflurane delivered by the 'AnaConDa'Peter V Sackey
Department of Anesthesiology, Karolinska University Hospital Solna, Stockholm, Sweden
Paediatr Anaesth 15:879-85. 2005..Inhaled sedation of isoflurane with AnaConDa was effective in these patients. It may provide an alternative in difficult cases needing prolonged sedation and should be evaluated further...
- Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fearJames M Sonner
Department of Anesthesiology, University of California, San Francisco, San Francisco, California, USA
Mol Pharmacol 68:61-8. 2005..These results indicate that alpha1-containing GABA(A)-Rs in the hippocampus, amygdala, and/or cortex influence the amnestic effects of inhaled anesthetics and may be an important molecular target of the drug isoflurane...
- The effect of inhalational anaesthetics on QTc intervalA H Karagoz
Hacettepe University, Faculty of Medicine, Department of Anaesthesiology and Reanimation, Ankara, Turkey
Eur J Anaesthesiol 22:171-4. 2005..The aim of this study was to assess time dependent cumulative effects of three different inhalation anaesthetics on QTc interval during the maintenance of anaesthesia...
- Hypotensive anesthesia and recovery of cognitive function in long-term craniofacial surgeryValentina Caverni
Department of Anesthesiology and Resuscitation, Umberto I Polyclinic, La Sapienza University, Rome, Italy
J Craniofac Surg 16:531-6. 2005..Early and late recovery were faster and more complete in the D group; P < 0.05. Postoperative morbidity (nausea, vomiting, shivering, pain, and edema) was slight and did not significantly differ among the groups...
- Postoperative pain and analgesic requirements after anesthesia with sevoflurane, desflurane or propofolArgyro Fassoulaki
Department of Anesthesiology, Aretaieio Hospital, 76 Vassilissis Sofias Ave, 11527, Athens, Greece
Anesth Analg 107:1715-9. 2008....
- Dental anaesthesia in a patient with Noonan syndromeC H Ng
Br J Oral Maxillofac Surg 43:267-8. 2005
- Pressure support ventilation with the ProSeal laryngeal mask airway. A comparison of sevoflurane, isoflurane and propofolC Keller
Leopold Franzens University, Department of Anesthesia and Intensive Care Medicine, Innsbruck, Austria
Eur J Anaesthesiol 22:630-3. 2005..We compared propofol, sevoflurane and isoflurane for maintenance of anaesthesia with the ProSeal laryngeal mask airway during pressure support ventilation...
- Sevoflurane-remifentanil vs isoflurane-remifentanil for the surgical correction of craniosynostosis in infantsDomenico Pietrini
Department of Anesthesiology, Pediatric Neuroanesthesiology, Catholic University Medical School, Rome, Italy
Paediatr Anaesth 15:653-62. 2005..The aim of the present study was to compare the efficacy of isoflurane-remifentanil and sevoflurane-remifentanil combinations during neurosurgical correction craniosynostosis...
- Comparison of isoflurane and sevoflurane anesthesia after premedication with butorphanol in the green iguana (Iguana iguana)Sonia M Hernandez-Divers
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
J Zoo Wildl Med 36:169-75. 2005..The cardiopulmonary effects of butorphanol-isoflurane and butorphanol-sevoflurane assessed in this study are similar, and both inhalants appear to be safe and effective for induction and maintenance in the green iguana...
- Effects of halothane, isoflurane, and sevoflurane on lipid peroxidation following experimental closed head trauma in ratsA Yurdakoc
Department of Anaesthesiology, Kirklareli Hospital, Edirne, Turkey
Acta Anaesthesiol Scand 52:658-63. 2008..In a rat closed head trauma model we examined both the time course of lipid peroxidation and the effects of halothane, isoflurane, and sevoflurane on it by analysis of malondialdehyde (MDA) formation...
- Remifentanil-propofol in vertebral disk operations: hemodynamics and recovery versus desflurane-n(2)o inhalation anesthesiaMuhammet Gozdemir
Ataturk Research and Training Hospital, Department of Anesthesiology, Ankara, Turkey
Adv Ther 24:622-31. 2007..Because of the lack of residual analgesic effects, postoperative analgesic treatment should be initiated immediately in patients undergoing TIVA...
- Protective effects of volatile agents against acetylcholine-induced bronchoconstriction in isolated perfused rat lungsE Lele
Anaesthesiological Investigations Unit, University of Geneva, Geneva, Switzerland
Acta Anaesthesiol Scand 50:1145-51. 2006....
- Effects of halothane, sevoflurane and desflurane on the force-frequency relation in the dog heart in vivoBenedikt Preckel
Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Postbus 22660 H1Z 139, 1100 DD Amsterdam, The Netherlands
Can J Anaesth 53:1118-25. 2006..We hypothesized that frequency potentiation is altered by volatile anesthetics and investigated the influence of halothane (H), sevoflurane (S) and desflurane (D) on the positive staircase phenomenon in dogs in vivo...
- The effect of nitrous oxide on halothane, isoflurane and sevoflurane requirements in ventilated dogs undergoing ovariohysterectomyT Duke
Department Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada
Vet Anaesth Analg 33:343-50. 2006..To examine the effect of 64% nitrous oxide (N2O) on halothane (HAL), isoflurane (ISO) or sevoflurane (SEV) requirements in dogs undergoing ovariohysterectomy...
- Differences in need for hemodynamic support in horses anesthetized with sevoflurane as compared to isofluraneBernd Driessen
Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, Section of Critical Care Anesthesia, University of Pennsylvania, PA 19348, USA
Vet Anaesth Analg 33:356-67. 2006..To study whether hemodynamic function in horses, particularly mean arterial blood pressure (MAP), is better maintained with sevoflurane than isoflurane, thus requiring less pharmacological support...
- The effect of halothane, isoflurane, sevoflurane and propofol infusion on renal function after coronary artery bypass surgeryFatma Saricaoglu
Hacettepe University, Department of Anesthesia and Reanimation, Ankara, Turkey
Middle East J Anaesthesiol 18:955-64. 2006..It is concluded that, halothane, isoflurane, sevoflurane and propofol infusion anesthesia as part of anesthesia maintenance for elective coronary artery bypass surgery does not affect early postoperative renal functions...
- [Is entropy a monitor for the guidance of intraoperative analgesia?]E Dierckens
clinique d anesthésie réanimation, Hopital Huriez, CHRU de Lille, rue Michel Polonowski, 59037 Lille Cedex, France
Ann Fr Anesth Reanim 26:113-8. 2007..Comparison between BIS (Bispectral Index) and state (SE) and response (RE) entropy during laparotomy for inflammatory bowel disease patients (IBD) and evaluation of the variations of RE and SE during nociceptive stimulation...
- Comparison of sevoflurane and isoflurane in OPCAB surgeryB G Venkatesh
Department of Anaesthesiology and Critical Care, Escorts Heart Institute and Research Centre, New Delhi
Ann Card Anaesth 10:46-50. 2007..We conclude that sevoflurane and isoflurane can both be safely used in OPCAB surgery, but the awakening and extubation times are significantly less with sevoflurane...
- Inhalation anesthesia in Dumeril's monitor (Varanus dumerili) with isoflurane, sevoflurane, and nitrous oxide: effects of inspired gases on induction and recoveryMads F Bertelsen
Toronto Zoo, 361A Old Finch Avenue, Scarborough, Ontario, Canada
J Zoo Wildl Med 36:62-8. 2005..There were no significant differences in recovery times between isoflurane and sevoflurane or between sevoflurane in 100% O2 and sevoflurane combined with N2O. Similar recovery times were observed in animals recovering in 100 and 21% O2...
- A study of the effect of hemorrhage on the cardiorespiratory actions of halothane, isoflurane and sevoflurane in the dogFrancisco J Teixeira Neto
Department of Veterinary Surgery and Anesthesia, Faculdade de Medicina Veterinaria e Zootecnia, Universidade Estadual Paulista, Botucatu, Sao Paulo, Brazil
Vet Anaesth Analg 34:107-16. 2007..To compare the cardiorespiratory changes induced by equipotent concentrations of halothane (HAL), isoflurane (ISO) and sevoflurane (SEVO) before and after hemorrhage...
- Cost minimisation and cost effectiveness in anaesthesia for total hip replacement surgery, in Belgium? A study comparing three general anaesthesia techniquesJ L Demeere
Kliniek St Jan Brussels, Belgium
Acta Anaesthesiol Belg 57:145-51. 2006..Cost minimisation based on anaesthetic medication is ridiculously by small considering the total cost of the procedure...
- Differential effects of volatile and intravenous anesthetics on the activity of human TASK-1C Putzke
Department of Anesthesiology and Critical Care Medicine, Philipps University Marburg, Baldingerstrasse 1, 35043, Marburg, Germany
Am J Physiol Cell Physiol 293:C1319-26. 2007..In contrast, stimulatory effects of sevoflurane and enantiomeric isoflurane on human TASK-1 can be observed at clinically relevant concentrations...
- [Specific features of anesthesia for primary surgery in children with facial and palatal clefts: retrospective study in 93 children at the Besançon University Hospital]M Brix
Rev Stomatol Chir Maxillofac 107:126-8. 2006
- Evaluation of induction characteristics and hypnotic potency of isoflurane and sevoflurane in healthy dogsErik H Hofmeister
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
Am J Vet Res 69:451-6. 2008..To determine induction characteristics and the minimum alveolar concentration (MAC) at which consciousness returned (MACawake) in dogs anesthetized with isoflurane or sevoflurane...
- [Low flow anaesthesia with isoflurane and sevoflurane in the dog]Sabine Kramer
Klinik für Kleintiere, Stiftung Tierarztliche Hochschule Hannover
Berl Munch Tierarztl Wochenschr 121:53-65. 2008..Even considering that sevoflurane is more expensive than isoflurane, the use of the low flow technique decreases the cost of anaesthesia due to the reduced volatile anaesthetic consumption...
- Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and StatinsTHOMAS JAY EBERT; Fiscal Year: 2013..These studies will carefully describe the effects of glucose and statins on the function of the lining of blood vessels in humans. This new knowledge might lessen unwanted side effects related to diabetes. ..
- Cellular Mechanisms of Vasoregulation by Volatile AnestheticsRostislav Bychkov; Fiscal Year: 2012..provided by applicant): Two-pore-domain K+channels (K2P-channels) represent targets for actions of inhalation anesthetics on neurons...
- Genomics and pharmacodynamics of statin-related rhabdomyolysisBruce M Psaty; Fiscal Year: 2013..For some people, statins may be the equivalent of fluorinated- inhalation anesthetics, which precipitate malignant hyperthermia (MH) in susceptible individuals...
- GENERAL ANESTHETICS AND CLONED VOLTAGE-GATED CHANNELSANA CORREA; Fiscal Year: 2000..The specific aims are: 1) To characterize the action of general inhalation anesthetics on the macroscopic gating and conductance properties of cloned voltage-gated ion channels...
- MYOCARDIAL ISCHEMIA INDUCED BY INHALED ANESTHETICSCHARLES BUFFINGTON; Fiscal Year: 1993..There is accumulating evidence that halothane and isoflurane, the major inhalation anesthetics in use today, differ in their effects on coronary vessels and platelets and thus differ in their tendency ..
- Role of Anesthetic Isoflurane in Alzheimer's Disease: In Vivo InvestigationZhongcong Xie; Fiscal Year: 2009..PUBLIC HEALTH RELEVANCE The proposed research will determine potential neurotoxic effects of inhalation anesthetics isoflurane, sevoflurane and desflurane in inducing cell death and increasing amyloid-b protein in mice and ..
- ACTION OF INHALED ANESTHETICS ON SYNAPTIC RECEPTORSHoward Wang; Fiscal Year: 1991..If this hypothesis is correct, one can expect to observe specific binding of inhalation anesthetics to synaptic receptors...
- INTERFACIAL ACTION OF INHALATION ANESTHETICSIssaku Ueda; Fiscal Year: 1992..The microscopic properties are measured by nuclear magnetic resonance spectroscopy, fluorescence spectrophotometry, Raman and Fourier-transform infrared spectroscopy, etc...
- BIOLOGICAL EFFECTS OF NITROUS OXIDE USED IN DENTISTRYA Verrusio; Fiscal Year: 1980....
- SITES AND MECHANISMS OF INHALED ANESTHETIC ACTIONSEDMOND EGER; Fiscal Year: 2008..abstract_text> ..
- BRAIN AND SPINAL CORD CONTRIBUTIONS TO ANESTHETIC ACTIONJOSEPH ANTOGNINI; Fiscal Year: 2005..This information will aid the development of newer and safer anesthetics, as well as lead to clinically useful means of modulating the neurotransmitter systems that are themselves modulated by anesthetics. ..
- ANESTHETIC EFFECTS ON SENSORIMOTOR INTEGRATIONJOSEPH ANTOGNINI; Fiscal Year: 2009..Understanding how and where anesthetics act will eventually lead to the development of better and safer anesthetics, thereby decreasing peri-operative morbidity and mortality and improving public health. ..
- Genes Underlying the Response to Inhaled AnestheticsJames Sonner; Fiscal Year: 2008....
- ANESTHETIC RENAL METABOLISM--MECHANISMS AND CONSEQUENCESEvan Kharasch; Fiscal Year: 2002..More broadly, resulting biochemical and clinical insights will be applicable to the numerous other nephrotoxic haloalkenes that are ubiquitous environmental contaminants. ..
- Novel noninvasive assessment of cytochrome P450 activityEvan Kharasch; Fiscal Year: 2009..This approach may identify inter-individual variability in drug disposition and response;permit more individualized dosing, and reduces the cost of drug interaction studies. ..
- Volatile Anesthetic Action in Vertebrate Locomotor SystemsSteven L Jinks; Fiscal Year: 2010..Results from these projects will increase our understanding of how and where anesthetics act in the nervous system, contributing to the development of safer anesthetics and clinical practices. ..
- INHALATIONAL ANESTHETIC BINDING STUDIESRoderic Eckenhoff; Fiscal Year: 2007..abstract_text> ..
- The Role of the Amygdala in Anesthetic-Induced AmnesiaMICHAEL ALKIRE; Fiscal Year: 2006..abstract_text> ..
- Interaction of amyloid beta and inhaled anestheticsRoderic Eckenhoff; Fiscal Year: 2006..These studies will provide the feasibility to extend this hypothesis to animal models and ultimately to clinical studies of the interaction between anesthetics and neurodegeneration. ..
- General Anesthetics and nAcCHOR Agonist AffinityDouglas Raines; Fiscal Year: 2004....
- AGE RELATED CARDIAC SENSITIVITY TO VOLATILE ANESTHETICSY S Prakash; Fiscal Year: 2001....
- COMPARING THREE ELECTRODE PLACEMENTS TO OPTIMIZE ECTKeith Rasmussen; Fiscal Year: 2005..The results of this study will promote more effective and safer treatment of the most severely ill depressed patients. ..
- VOLATILE ANESTHETICS IN PRESSURE OVERLOAD HYPERTROPHYJames Hannon; Fiscal Year: 2002....
- Mechanisms of experimental drug-induced hepatitisDolores Njoku; Fiscal Year: 2007..3) To confirm antigenic spread in TFA-CYP2E1-immunized mice using spleenocyte proliferation assays stimulated with ERp58 and ASGPR and analyzed as in Specific Aim 2. [unreadable] [unreadable] [unreadable] [unreadable]..
- Intracellular signaling in anesthetic and hypoxic preconditioning of neuronsPhilip E Bickler; Fiscal Year: 2010..The work will also identify why the aging brain may not be able to benefit from the neuroprotective actions of anesthetics or other preconditioning treatments. ..
- ANESHETIC MODULATION OF NATIVE NICOTINIC RECEPTORSPamela Flood; Fiscal Year: 2003..The resulting information will provide understanding of the molecular mechanism underlying one of the anesthetic effects that limit anesthetic safety. ..
- MECHANISMS OF ANESTHETIC ACTION ON SMOOTH MUSCLEJUDY SU; Fiscal Year: 2004Description (provided by applicant): Inhalation anesthetics simultaneously cause vasoconstriction and vasodilation in different vascular beds...
- Cerebral Edema in Pediatric Diabetic KetoacidosisMONICA VAVILALA; Fiscal Year: 2006..unreadable] [unreadable]..
- BACKGROUND POTASSIUM CHANNELS AS ANESTHETIC TARGETSCHARLES YOST; Fiscal Year: 2008..An understanding of the basic mechanisms underlying anesthesia has the potential to lead to improved anesthetic drugs or techniques. ..
- Gaq modulation of neuronal K+ channels: novel mechanisms and targetsDouglas A Bayliss; Fiscal Year: 2011..These experiments will characterize molecular substrates underlying native neuronal neurotransmitter-modulated background K+ currents and examine molecular mechanisms by which they are modulated. ..
- Hemodynamics and Outcome in Pediatric Brain InjuryMONICA VAVILALA; Fiscal Year: 2007..The proposed research will be carried out at the University of Washington, well-known known for mentored patient-oriented research. ..
- VOLATILE ANESTHETIC ACTION ON CARDIAC K CHANNELSWai Meng Kwok; Fiscal Year: 2008..This novel approach to anesthetic interaction with ion channels will have functional significance in the diseased myocardium where up- and downregulation of channel subunits are known to occur. ..
- Mechanisms of peripheral vascular anesthetic sensitivityTHOMAS STEKIEL; Fiscal Year: 2008..Additionally, this model also greatly facilitates development of congenic sub strains (partial chromosomal substitutions) for use in subsequent genetic mapping studies. ..
- ANESTHESIA AND COCAINE INDUCED CNS EXCITOTOXICITYROBERT WHITTINGTON; Fiscal Year: 2003..This award will allow me to obtain the investigational skills and knowledge base that will enable me to develop into a clinician-scientist and independent investigator in anesthesiology and neuroscience research. ..
- CELLULAR/MOLECULAR MECHANISMS OF GIRK CHANNEL INHIBITIONDOUGLAS BAYLISS; Fiscal Year: 2003..abstract_text> ..
- Estrogen and the Aging Blood Brain BarrierOAK CHI; Fiscal Year: 2002..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
- Structure of the Glycine Receptor's Alcohol Binding SiteINGRID LOBO; Fiscal Year: 2003..abstract_text> ..
- POTASSIUM CHANNEL ACTIVATION BY VOLATILE ANESTHETICSCHARLES YOST; Fiscal Year: 2002..Studies will be carried out in cerebellar granule neurons using whole cell ruptured patch and excised patch techniques on neurons in culture and in thin slices. ..
- PERINATAL HYPOXIA: ADRENOCORTICAL-METABOLIC ADAPTATIONSHershel Raff; Fiscal Year: 2006..Characterization of the hypothalamic-pituitary-adrenal and metabolic adaptations to perinatal hypoxia can lead to new diagnostic approaches and therapies to minimize morbidity and mortality. ..
- ARRAY SCREENING FOR LESCH NYHAN DISEASETheodore Friedmann; Fiscal Year: 2002..3. filter and chip array screening can identify individual genes and patterns of genes whose expression is modulated by HPRT expression. ..
- Ischemic Spasticity: Modulation by GAD65 Gene DeliveryMartin Marsala; Fiscal Year: 2010....
- Kinetics of Ligand Binding to Synaptic Ion ChannelsJAMES DILGER; Fiscal Year: 2006..4. Use isothermal titration calorimetry to measure the thermodynamics of ligand binding to acetylcholine binding protein - a water soluble protein whose structure is being used as a template for the acetylcholine receptor. ..
- Biobehavioral Heterogeneity of Crack Cocaine DependenceLeslie Prichep; Fiscal Year: 2003..Application of new mathematical algorithms will permit identification of the most probable neuroanatomical sources generating the QEEG, which may improve understanding of underlying mechanisms and help target new medications. ..
- GENE TRANSFER TO THE VASCULAR ENDOTHELIUMTheodore Friedmann; Fiscal Year: 2003..Finally, we propose to characterize the biodistribution of these targeted vectors by sensitive fluorescence methods and correlate vector attachment with sites of endothelial-specific gene expression. ..
- SITES OF ACTION OF INHALATIONAL ANESTHETICS ON HPVJames Baumgardner; Fiscal Year: 2001..Understanding the sites of anesthetic action is of fundamental importance but may also lead to improved patient management. ..
- Does spinal manipulation speed determine neural responseJoel Pickar; Fiscal Year: 2002..Teaching the manual skill of spinal manipulation could be approached from the perspective of quantifying the velocity with which the clinician applies a spinal manipulation. ..
- The role of the TM2-TM3 linker in ethanol modulation of the Glycine ReceptorMICHELLE DUPRE; Fiscal Year: 2008..Additionally, because glycine shares homology with other cys-loop ion channels, including GABAA, nicotinic acetylcholine, and serotonin-3 receptors, [unreadable] [unreadable] [unreadable]..
- New PET Radiotracers-Monoamine TransportersMichael Kilbourn; Fiscal Year: 2003....
- Signal Transduction Mechanisms in Neuroendocrine NeuronsArshad Khan; Fiscal Year: 2006..This training will further my career goal of studying cellular signaling using an in vivo approach. ..
- Microarray analysis of neuronal ischemic preconditioningPiyush Patel; Fiscal Year: 2007..A substantial benefit of the research will be the identification of novel therapeutic targets upon which future drug development can be based. ..
- Cognitive Function After Intracranial Aneurysm SurgerySatwant Samra; Fiscal Year: 2005..Information gained from this investigation will be important in giving a prognosis for returning back to work as well as planning rehabilitation of patients suffering from aneurysmal SAH in future. ..
- PKC modulation of calcium current and anesthetic actionGANESAN KAMATCHI; Fiscal Year: 2007..abstract_text> ..
- AGING AND PERIOPERATIVE OUTCOMESJACQUELINE LEUNG; Fiscal Year: 2005..We believe that our studies will provide important results contributing ultimately to the improvement of perioperative outcomes in geriatric patients. ..
- Ischemic Paraplegia: Modulation by Stem Cell ImplantMartin Marsala; Fiscal Year: 2005....
- Na+/H+ EXCHANGER AND CARDIAC HYPOTHERMIA: ROLE ROSAmadou Camara; Fiscal Year: 2007..Emphasis will be placed on the effects of drug-induced blockade of mitochondrial ROS formation, NHE activity and KAav channel opening on cellular cation balance and mitochondrial bioenergetics. ..
- Developmental Psychobiology SymposiaApril Ronca; Fiscal Year: 2007..abstract_text> ..
- Methods for in vivo behavioral observation of the mouse fetusApril Ronca; Fiscal Year: 2008..Ultimately, the application of these methods will increase our knowledge about developmental disabilities that will allow their prevention, prenatal detection, and cure. [unreadable] [unreadable] [unreadable]..
- The Effect of Sedation on Restorative SleepAvery Tung; Fiscal Year: 2005..Knowledge from this proposal will provide scientific insight into the relationships between anesthesia and sleep, and may lead to more effective clinical use of ICU sedatives. ..