inhalation anesthetics

Summary

Summary: Gases or volatile liquids that vary in the rate at which they induce anesthesia; potency; the degree of circulation, respiratory, or neuromuscular depression they produce; and analgesic effects. Inhalation anesthetics have advantages over intravenous agents in that the depth of anesthesia can be changed rapidly by altering the inhaled concentration. Because of their rapid elimination, any postoperative respiratory depression is of relatively short duration. (From AMA Drug Evaluations Annual, 1994, p173)

Top Publications

  1. ncbi Inhalation anesthetics induce apoptosis in normal peripheral lymphocytes in vitro
    H Matsuoka
    Department of Anesthesiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Anesthesiology 95:1467-72. 2001
  2. ncbi Influence of inhalation anesthesia assessed by comprehensive gene expression profiling
    Atsuhiro Sakamoto
    Department of Anesthesiology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Gene 356:39-48. 2005
  3. ncbi Validation of several types of noxious stimuli for use in determining the minimum alveolar concentration for inhalation anesthetics in dogs and rabbits
    Alexander Valverde
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
    Am J Vet Res 64:957-62. 2003
  4. ncbi Toward a unified theory of narcosis: brain imaging evidence for a thalamocortical switch as the neurophysiologic basis of anesthetic-induced unconsciousness
    M T Alkire
    Department of Anesthesiology, University of California at Irvine, Irvine, California 92697, USA
    Conscious Cogn 9:370-86. 2000
  5. ncbi The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the alpha(2) adrenergic sedative dexmedetomidine, and cannabinoid agonists
    Anni Maija Linden
    Institute of Biomedicine, Pharmacology, University of Helsinki, P O Box 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
    J Pharmacol Exp Ther 317:615-26. 2006
  6. ncbi Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humans
    Kaike K Kaisti
    Department of Anesthesiology, Turku University Hospital, Finland
    Anesthesiology 99:603-13. 2003
  7. ncbi Inhalation anesthetics: a review
    G Torri
    Department of Anesthesiology, S Raffaele University, Milan, Italy
    Minerva Anestesiol 76:215-28. 2010
  8. ncbi Effects of inhalation anesthetics halothane, sevoflurane, and isoflurane on human cell lines
    Slavica Kvolik
    Department of Anesthesiology, Clinical Hospital Osijek, J Huttlera 4, 31000 Osijek, Croatia
    Life Sci 77:2369-83. 2005
  9. ncbi Effects of halothane and propofol on excitatory and inhibitory synaptic transmission in rat cortical neurons
    Akira Kitamura
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    J Pharmacol Exp Ther 304:162-71. 2003
  10. ncbi Isoflurane disrupts central pattern generator activity and coordination in the lamprey isolated spinal cord
    Steven L Jinks
    Department of Anesthesiology and Pain Medicine, University of California School of Medicine, Davis, CA 95616, USA
    Anesthesiology 103:567-75. 2005

Detail Information

Publications218 found, 100 shown here

  1. ncbi Inhalation anesthetics induce apoptosis in normal peripheral lymphocytes in vitro
    H Matsuoka
    Department of Anesthesiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Anesthesiology 95:1467-72. 2001
    ..hypothesized that perioperative lymphocytopenia is partially caused by apoptosis of lymphocytes induced by inhalation anesthetics. Therefore, they evaluated whether sevoflurane and isoflurane induce apoptosis of normal peripheral ..
  2. ncbi Influence of inhalation anesthesia assessed by comprehensive gene expression profiling
    Atsuhiro Sakamoto
    Department of Anesthesiology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Gene 356:39-48. 2005
    ..Our findings provide the first assessment for the influence of inhalation anesthesia by approaches of experimental biology and genome science...
  3. ncbi Validation of several types of noxious stimuli for use in determining the minimum alveolar concentration for inhalation anesthetics in dogs and rabbits
    Alexander Valverde
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
    Am J Vet Res 64:957-62. 2003
    ..To compare 3 types of noxious stimuli applied to various anatomic areas of anesthetized dogs and rabbits for determination of the minimum alveolar concentration (MAC)...
  4. ncbi Toward a unified theory of narcosis: brain imaging evidence for a thalamocortical switch as the neurophysiologic basis of anesthetic-induced unconsciousness
    M T Alkire
    Department of Anesthesiology, University of California at Irvine, Irvine, California 92697, USA
    Conscious Cogn 9:370-86. 2000
    ....
  5. ncbi The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the alpha(2) adrenergic sedative dexmedetomidine, and cannabinoid agonists
    Anni Maija Linden
    Institute of Biomedicine, Pharmacology, University of Helsinki, P O Box 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
    J Pharmacol Exp Ther 317:615-26. 2006
    b>Inhalation anesthetics activate and cannabinoid agonists inhibit TWIK-related acid-sensitive K(+) channels (TASK)-1 two-pore domain leak K(+) channels in vitro...
  6. ncbi Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humans
    Kaike K Kaisti
    Department of Anesthesiology, Turku University Hospital, Finland
    Anesthesiology 99:603-13. 2003
    ....
  7. ncbi Inhalation anesthetics: a review
    G Torri
    Department of Anesthesiology, S Raffaele University, Milan, Italy
    Minerva Anestesiol 76:215-28. 2010
    ..The different mechanisms of action of the inhalation agents and the evolution from a unitary theory of inhaled anesthetics to a multiple mechanism concept are presented...
  8. ncbi Effects of inhalation anesthetics halothane, sevoflurane, and isoflurane on human cell lines
    Slavica Kvolik
    Department of Anesthesiology, Clinical Hospital Osijek, J Huttlera 4, 31000 Osijek, Croatia
    Life Sci 77:2369-83. 2005
    ..4% (p=0.007). A DNA fragmentation was observed in Caco-2 and MIA PaCa-2 cells. Exposition of phosphatidylserine on outer lipid bilayer plasma membrane of tumor cell treated by halothane proved apoptosis as mode of cell death...
  9. ncbi Effects of halothane and propofol on excitatory and inhibitory synaptic transmission in rat cortical neurons
    Akira Kitamura
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    J Pharmacol Exp Ther 304:162-71. 2003
    ..The additional calcium-dependent inhibition of mIPSC and mEPSC frequency by halothane (but not propofol) suggests a more general mechanism by this anesthetic on presynaptic transmitter release...
  10. ncbi Isoflurane disrupts central pattern generator activity and coordination in the lamprey isolated spinal cord
    Steven L Jinks
    Department of Anesthesiology and Pain Medicine, University of California School of Medicine, Davis, CA 95616, USA
    Anesthesiology 103:567-75. 2005
    ..However, it is unclear whether volatile anesthetics depress locomotor interneurons comprising central pattern generators or disrupt intersegmental central pattern generator coordination...
  11. ncbi Cholinergic reversal of isoflurane anesthesia in rats as measured by cross-approximate entropy of the electroencephalogram
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 99:1125-31. 2003
    ..The effect of cholinergic agents on C-ApEn has not been examined. Here, the authors test the hypothesis that cholinergic activation reverses the effect of isoflurane anesthesia on C-ApEn...
  12. pmc Isoflurane depresses glutamate release by reducing neuronal excitability at the Drosophila neuromuscular junction
    David J Sandstrom
    Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health MSC 4034, Bethesda, MD 20892, USA
    J Physiol 558:489-502. 2004
    ..These results provide a cellular context for ongoing genetic and neurophysiological analyses of volatile anaesthetic action in Drosophila, and suggest candidate anaesthetic target molecules...
  13. ncbi Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane
    Mark Liao
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 101:412-8, table of contents. 2005
    ....
  14. ncbi Long-term exposure to local but not inhalation anesthetics affects neurite regeneration and synapse formation between identified lymnaea neurons
    Shin Onizuka
    Calgary Brain Institute, Faculty of Medicine, University of Calgary, and Department of Anesthesiology, Miyazaki Medical College, University of Miyazaki, Japan
    Anesthesiology 102:353-63. 2005
    ..Because synaptic transmission recovers rapidly from various inhalation anesthetics, it is generally assumed that their effects on nerve regeneration and synapse formation that precede ..
  15. ncbi Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane
    M D Krasowski
    Department of Committee on Neurobiology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Pharmacol 53:530-8. 1998
    ..These data indicate that the receptor structural requirements for positive modulation by volatile and intravenous general anesthetics may be quite distinct...
  16. ncbi Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats
    Deborah J Culley
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Anesthesiology 100:309-14. 2004
    ..This experiment was designed to test the hypothesis that learning of new information is particularly susceptible to prolonged disruption after general anesthesia...
  17. ncbi Spatio-temporal characteristics of low-frequency BOLD signal fluctuations in isoflurane-anesthetized rat brain
    Sridhar S Kannurpatti
    Department of Radiology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Neuroimage 40:1738-47. 2008
    ..Also, a high inter-hemispheric synchrony combined with different phase characteristics of the low-frequency BOLD fluctuations particularly in the hippocampus relative to the cortex emphasizes distinct functional networks...
  18. ncbi Isoflurane blocks synaptic plasticity in the mouse hippocampus
    W Simon
    Max-Planck-Institute of Psychiatry, Munich, Germany
    Anesthesiology 94:1058-65. 2001
    ..An impairment of these processes may be a cause for the transient loss of recall and cognitive impairment after anesthesia in juvenile and adult brains...
  19. ncbi A new device to reduce the consumption of a halogenated anaesthetic agent
    M Enlund
    University Department of Anaesthesia and Intensive Care, Samariterhemmets Sjukhus Uppsala, Sweden
    Anaesthesia 56:429-32. 2001
    ..2 (3.0) ml x MAC-hour(-1) with the new device (p < 0.05). This corresponded to a 40% saving in the consumption of isoflurane. The amount of isoflurane that was scavenged to the atmosphere was reduced by an average of 55%...
  20. ncbi AnaConDa reflection filter: bench and patient evaluation of safety and volatile anesthetic conservation
    Jerôme Berton
    Anesthesia and Intensive Care Unit, Angers Teaching Hospital, Angers, France
    Anesth Analg 104:130-4. 2007
    ..The AnaConDa filter permits administration of volatile anesthetic without the use of an anesthesia machine. It is intended for use in the intensive care unit...
  21. ncbi Up-regulation of hypoxia inducible factor 1alpha by isoflurane in Hep3B cells
    Qi Fang Li
    Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dongfang Road, Shanghai 200127, China
    Anesthesiology 105:1211-9. 2006
    ..Little is known about the extent to which induction of HIF-1alpha is affected by isoflurane...
  22. ncbi Isoflurane disrupts anterio-posterior phase synchronization of flash-induced field potentials in the rat
    Olga A Imas
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA
    Neurosci Lett 402:216-21. 2006
    ..These findings suggest that a disruption of long-range anterio-posterior rather than local anterior synchronization of neuronal activity precedes the anesthetic-induced loss of consciousness...
  23. ncbi Effect of volatile anesthetics on interhemispheric EEG cross-approximate entropy in the rat
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Brain Res 954:123-31. 2002
    ..The results suggest that C-ApEn of bihemispheric EEG is a sensitive, agent-specific correlate of anesthetics' central effect...
  24. ncbi Isoflurane pretreatment inhibits lipopolysaccharide-induced inflammation in rats
    Roman V Plachinta
    Department of Anesthesiology University of Virginia Health System, Charlottesville, Virginia 22908 0710, USA
    Anesthesiology 98:89-95. 2003
    ....
  25. ncbi Mechanism of hepatic heme oxygenase-1 induction by isoflurane
    Alexander Hoetzel
    Department of Anesthesiology and Critical Care Medicine, University of Freiburg, Germany
    Anesthesiology 104:101-9. 2006
    ..Because the activating cascade remained unclear, it was the aim of this study to identify the underlying mechanism of this effect...
  26. ncbi The anesthetic conserving device compared with conventional circle system used under different flow conditions for inhaled anesthesia
    Augusto Tempia
    Istituto di Anestesia e Rianimazione, Ospedale San Luigi di Orbassano, Orbassano TO, Italy
    Anesth Analg 96:1056-61, table of contents. 2003
    ..Respiratory gas humidification was always adequate. Sevoflurane ambient concentration with the ACD was 1-70 ppb. The ACD is a valid and simple alternative to low-flow systems...
  27. ncbi Isoflurane and propofol inhibit voltage-gated sodium channels in isolated rat neurohypophysial nerve terminals
    Wei Ouyang
    Department of Anesthesiology, Box 50, LC 203, 525 E 68th St, Weill Medical College of Cornell University, New York, NY 10021, USA
    Mol Pharmacol 64:373-81. 2003
    ..Inhibition of voltage-gated Na+ channels may contribute to the presynaptic effects of general anesthetics on nerve terminal excitability and neurotransmitter release...
  28. ncbi Isoflurane preconditioning decreases glutamate receptor overactivation-induced Purkinje neuronal injury in rat cerebellar slices
    Shuqiu Zheng
    Department of Anesthesiology, University of Virginia Health System, One Hospital Drive, P O Box 800710, Charlottesville, VA 22908 0710, USA
    Brain Res 1054:143-51. 2005
    ..Thus, isoflurane preconditioning reduced glutamate receptor overstimulation-induced neuronal injury/death. This neuroprotection may be PKC- and NOS-dependent...
  29. ncbi Isoflurane inhibits transmitter release and the presynaptic action potential
    Xin Sheng Wu
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri, USA
    Anesthesiology 100:663-70. 2004
    ..However, the extent of the presynaptic contribution has not been quantitatively studied. Furthermore, the mechanism underlying the presynaptic contribution remains unclear...
  30. ncbi Direct cerebral vasodilatory effects of sevoflurane and isoflurane
    B F Matta
    Department of Anaesthesia, Addenbrooke s Hospital, Cambridge, United Kingdom
    Anesthesiology 91:677-80. 1999
    ..This study compared the direct cerebral vasodilatory actions of 0.5 and 1.5 minimum alveolar concentration (MAC) sevoflurane and isoflurane during an propofol-induced isoelectric electroencephalogram...
  31. ncbi Up-regulation of heme oxygenase-1 by isoflurane preconditioning during tolerance against neuronal injury induced by oxygen glucose deprivation
    Qifang Li
    Department of Anesthesiology, Shanghai Ninth People s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
    Acta Biochim Biophys Sin (Shanghai) 40:803-10. 2008
    ..These findings indicated that the neuroprotective role of isoflurane preconditioning against OGD-induced injury might be associated with its role in up-regulating HO-1 in ischemic neurons...
  32. ncbi A review of the safety of 50% nitrous oxide/oxygen in conscious sedation
    Valérie Collado
    Univ Clermont1, EA 3847, Faculté d Odontologie, 11 bvd Charles de Gaulle, F 63000 Clermont Ferrand, France
    Expert Opin Drug Saf 6:559-71. 2007
    ..No analysis of the effect of the method of administration was possible, nor could conclusions be drawn relating to the risk of occupational exposure...
  33. ncbi Inhalational or intravenous anesthetics for craniotomies? Pro inhalational
    Kristin Engelhard
    Klinik fur Anasthesiologie, Johannes Gutenberg Universitat, Mainz, Germany
    Curr Opin Anaesthesiol 19:504-8. 2006
    ....
  34. ncbi Cine-MRI assessment of cardiac function in mice anesthetized with ketamine/xylazine and isoflurane
    F Kober
    Centre de Resonance Magnetique Biologique et Medicale, Faculte de Medecine, 27 Bd Jean Moulin, 13005, Marseille, France
    MAGMA 17:157-61. 2004
    ....
  35. ncbi [Occupational exposure to inhalation anesthetics: 10 years of measurements at hospitals in Puglia]
    F Cassano
    Dipartimento di Medicina Interna e Medicina Pubblica, Sezione di Medicina del Lavoro, Universita degli Studi di Bari, Centro di Igiene Ambientale, Fondazione S Maugeri, Bari
    G Ital Med Lav Ergon 25:279-81. 2003
    ..Finally, the Authors prove the utility of the graphic representation of the measurements, conduced utilising dedicated instrumentation...
  36. ncbi Impaired acquisition of spatial memory 2 weeks after isoflurane and isoflurane-nitrous oxide anesthesia in aged rats
    Deborah J Culley
    Department of Anesthesiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Anesth Analg 99:1393-7; table of contents. 2004
    ..05). There were no differences in total number of errors (P < or = 0.06). Thus, spatial memory is impaired for 2 wk after general anesthesia in aged rats independent of whether nitrous oxide is used...
  37. pmc Desflurane selectively suppresses long-latency cortical neuronal response to flash in the rat
    Anthony G Hudetz
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 111:231-9. 2009
    ..The authors studied the effect of desflurane on resting and visual evoked unit activity in rat visual cortex in vivo...
  38. ncbi Inhalational anaesthetics in the ICU: theory and practice of inhalational sedation in the ICU, economics, risk-benefit
    Andreas Meiser
    Klinik fur Anaesthesiologie, St Josef Hospital, Ruhr Universitat Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Best Pract Res Clin Anaesthesiol 19:523-38. 2005
    ..The technical prerequisites are explained, and the practice and pitfalls of inhalational ICU sedation in general and when using the AnaConDa are described in detail...
  39. ncbi Prolonged isoflurane sedation of intensive care unit patients with the Anesthetic Conserving Device
    Peter V Sackey
    Department of Anesthesiology and Intensive Care Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
    Crit Care Med 32:2241-6. 2004
    ..To test the efficacy and patient safety of a new method for administering isoflurane for prolonged sedation in the intensive care unit...
  40. ncbi Safety of inhalation of a 50% nitrous oxide/oxygen premix: a prospective survey of 35 828 administrations
    Peter Onody
    Department of Clinical Research and Development, Air Liquide Santé International, Paris, France
    Drug Saf 29:633-40. 2006
    ..This prospective study, conducted in the same conditions imposed for testing a drug, aims to analyse the factors that affect tolerance of the 50% N(2)O/O(2) premix in a wide range of clinical indications...
  41. ncbi Genotoxicity of inhalation anesthetics halothane and isoflurane in human lymphocytes studied in vitro using the comet assay
    P Jaloszyński
    Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60 479, Poznan, Poland
    Mutat Res 439:199-206. 1999
    The alkaline single cell gel electrophoresis (comet) assay was applied to study genotoxic properties of two inhalation anesthetics-halothane and isoflurane-in human peripheral blood lymphocytes (PBL)...
  42. ncbi Population pharmacokinetics of sevoflurane in conjunction with the AnaConDa: toward target-controlled infusion of volatiles into the breathing system
    M Enlund
    Department of Anesthesia and Intensive Care, Central Hospital, Vasteras, Sweden
    Acta Anaesthesiol Scand 52:553-60. 2008
    ..We performed in vitro characterization of the device before developing a population pharmacokinetic model for sevoflurane administration with the AnaConDa, and retrospectively testing its performance (internal validation)...
  43. ncbi The effect of nitrous oxide on cerebral blood flow velocity in children anaesthetised with desflurane
    C Karsli
    Department of Anaesthesia, University of Toronto, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8
    Anaesthesia 58:24-7. 2003
    ..This may be due to a more potent cerebral vasodilatory effect of desflurane in children...
  44. ncbi The sevoflurane saving capacity of a new anaesthetic agent conserving device compared with a low flow circle system
    M Enlund
    University Department of Anaesthesia and Intensive Care, Uppsala, Sweden
    Acta Anaesthesiol Scand 46:506-11. 2002
    ..An anaesthetic agent conserving device (ACD) has been added to a Bain system to approach the agent-saving capacity of a low flow circle system...
  45. ncbi Functional comparison of anaesthetic agents during myocardial ischaemia-reperfusion using pressure-volume loops
    D T Andrews
    Cardiovascular and Therapeutics Unit, Department of Pharmacology, University of Melbourne, Melbourne, Australia
    Br J Anaesth 103:654-64. 2009
    ..Left ventricular (LV) pressure-volume (PV) loops were used to compare the functional effects that accompany the cardioprotection seen with desflurane, sevoflurane, and propofol in a rabbit preparation of coronary ischaemia-reperfusion (IR)...
  46. ncbi General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit
    Rachel Jurd
    Institute of Pharmacology and Toxicology, University of Zurich, CH 8057 Zurich, Switzerland
    FASEB J 17:250-2. 2003
    ....
  47. ncbi Circadian gene expression is suppressed during sevoflurane anesthesia and the suppression persists after awakening
    Katsuya Kobayashi
    Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Brain Res 1185:1-7. 2007
    ..This suggests that sevoflurane anesthesia may have effects at the molecular level and that these effects are long lasting...
  48. ncbi Cerebral blood volume (CBV) in humans during normo- and hypocapnia: influence of nitrous oxide (N(2)O)
    P Reinstrup
    Department of Anesthsiology, University Hospital, Lund, Sweden
    Anesthesiology 95:1079-82. 2001
    ..The aim of the current study was to evaluate the effect of N(2)O on three-dimensional regional and global CBV in humans during normocapnia and hypocapnia...
  49. ncbi Neocortex is the major target of sedative concentrations of volatile anaesthetics: strong depression of firing rates and increase of GABAA receptor-mediated inhibition
    Harald Hentschke
    Section of Experimental Anaesthesiology, University Clinics of Anaesthesiology, University of Tubingen, Tubingen, Germany
    Eur J Neurosci 21:93-102. 2005
    ....
  50. ncbi Isoflurane-induced surgical tolerance mediated only in part by beta3-containing GABA(A) receptors
    Sachar Lambert
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Eur J Pharmacol 516:23-7. 2005
    ..At high concentrations isoflurane also immobilizes beta3(N265M) mice, indicating that other targets also mediate immobility. Thus, our findings support a multisite model for the immobilizing action of isoflurane...
  51. pmc The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo
    Anant B Patel
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 102:5588-93. 2005
    ..The contribution of GABAergic neurons and inhibition to cortical energy metabolism has broad implications for the interpretation of functional imaging signals...
  52. ncbi Comparison of remifentanil and nitrous oxide in labour analgesia
    P Volmanen
    Department of Anaesthesia and Intensive Care, Lapland Central Hospital, Rovaniemi, Finland
    Acta Anaesthesiol Scand 49:453-8. 2005
    ..We compared the efficacy and side-effects of remifentanil with those of nitrous oxide during the first stage of labour...
  53. ncbi [AnaConDa as last resort treatment. Case report of a chronic obstructive pulmonary disease]
    E A Nickel
    Zentrum Anaesthesiologie, Rettungs und Intensivmedizin, Georg August Universitat Gottingen, 37099 Gottingen
    Anaesthesist 56:587-91. 2007
    ..Elimination of CO(2) was improved and weaning from controlled ventilation was achieved. After surgical removal of a pulmonary abscess and a total of 78 days of intensive care therapy, the patient was discharged in good health...
  54. ncbi Comparison of electroencephalogram activity and auditory evoked responses during isoflurane and halothane anaesthesia in the rat
    Luis M Antunes
    Comparative Biology Centre, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Vet Anaesth Analg 30:15-23. 2003
    ....
  55. ncbi Cerebrovascular reactivity to carbon dioxide is preserved during hypocapnia in children anesthetized with 1.0 MAC, but not with 1.5 MAC desflurane
    Igor A Luginbuehl
    Department of Anaesthesia, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Can J Anaesth 50:166-71. 2003
    ..Maintenance of cerebrovascular reactivity to CO(2) (CCO(2)R) is important during neurosurgical anesthesia. This study was designed to determine the effect of different desflurane concentrations on CCO(2)R in children...
  56. ncbi Use of the AnaConDa anaesthetic delivery system to treat life-threatening asthma
    H Thomson
    Anaesthesia 62:295-6. 2007
  57. ncbi The predictive performance of a pharmacokinetic model for manually adjusted infusion of liquid sevofluorane for use with the Anesthetic-Conserving Device (AnaConDa): a clinical study
    Javier F Belda
    Anesthesiology and Intensive Care Department, Hospital Clinico Universitario de Valencia, Avenida Blasco Ibanez, 17 46010 Valencia, Spain
    Anesth Analg 106:1207-14, table of contents. 2008
    ..We evaluated the predictive performance of a simple manually adjusted pump infusion scheme, for infusion of liquid sevoflurane to the AnaConDa...
  58. ncbi Ambient isoflurane pollution and isoflurane consumption during intensive care unit sedation with the Anesthetic Conserving Device
    Peter V Sackey
    Department of Anesthesiology and Intensive Care, Karolinska University Hospital Solna, Stockholm, Sweden
    Crit Care Med 33:585-90. 2005
    ..To examine ambient isoflurane pollution, scavenging efficacy, and isoflurane consumption using the Anesthetic Conserving Device (ACD) for prolonged isoflurane sedation in the intensive care unit...
  59. ncbi Volatile anesthetic action in a computational model of the thalamic reticular nucleus
    Allan Gottschalk
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Anesthesiology 110:996-1010. 2009
    ..Motivated by the role of the thalamus in consciousness and sensory processing, a computational model of the thalamic reticular nucleus was used to determine the collective impact on model behavior of VA action at multiple sites...
  60. ncbi Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: 4-aminopyridine-evoked release
    Robert I Westphalen
    Department of Anesthesiology LC 203, Weill Medical College of Cornell University, Box 50, 1300 York Avenue, New York, NY 10021, USA
    J Pharmacol Exp Ther 316:216-23. 2006
    ....
  61. ncbi Tolerability of an equimolar mix of nitrous oxide and oxygen during painful procedures in very elderly patients
    Carole Bauer
    Geriatrics Department, Georges Pompidou European Hospital, Paris, France
    Drugs Aging 24:501-7. 2007
    ..In this article, we investigate the tolerability of this equimolar mix in very elderly patients undergoing painful procedures...
  62. ncbi Comparison of anesthetic depth indexes based on thalamocortical local field potentials in rats
    Aura Silva
    Centro de Ciência Animal e Veterinária, Universidade de Tras os Montes e Alto Douro, Vila Real, Portugal
    Anesthesiology 112:355-63. 2010
    ....
  63. ncbi A comparative study of sevoflurane sedation with nitrous oxide sedation for dental surgery
    C Y Wang
    Department of Anaesthesia, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    Int J Oral Maxillofac Surg 31:506-10. 2002
    ..There was high acceptance of both methods and the patients rated the technique as equally satisfactory. We conclude that inhalation sedation with sevoflurane is a suitable alternative method to nitrous oxide sedation...
  64. ncbi A novel method for determining the blood/gas partition coefficients of inhalation anesthetics to calculate the percentage of loss at different temperatures
    N C Yang
    Department of Anesthesiology, Taichung Veterans General Hospital, Taichung, Taiwan
    J Anal Toxicol 28:122-7. 2004
    The loss by blood/gas (lambda) partition of inhalation anesthetics can be estimated by an equation for the percentage of loss...
  65. pmc The electrocortical effects of enflurane: experiment and theory
    James W Sleigh
    Department of Anaesthesiology, Waikato Clinical School, University of Auckland, Auckland, New Zealand
    Anesth Analg 109:1253-62. 2009
    ..In this study, we compared a theoretical computer model of this activity with real local field potential (LFP) data obtained from anesthetized rats...
  66. ncbi A randomized crossover comparison of the effects of propofol and sevoflurane on cerebral hemodynamics during carotid endarterectomy
    Timothy J McCulloch
    Department of Anaesthetics, University of Sydney, Sydney, and Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Anesthesiology 106:56-64. 2007
    ..Vasodilation is expected to increase blood flow, reduce ICAP, and reduce apparent zero flow pressure...
  67. ncbi TASK-3 knockout mice exhibit exaggerated nocturnal activity, impairments in cognitive functions, and reduced sensitivity to inhalation anesthetics
    Anni Maija Linden
    Institute of Biomedicine, Pharmacology, University of Helsinki, POB 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
    J Pharmacol Exp Ther 323:924-34. 2007
    ..Overall, our results suggest important contributions of TASK-3 channels in the neuronal circuits regulating circadian rhythms, cognitive functions, and mediating specific pharmacological effects...
  68. ncbi Effects of isoflurane and xenon on Ba2+-currents mediated by N-type calcium channels
    I L White
    Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Campus, 369 Fulham Road, London SW10 9NH, UK
    Br J Anaesth 94:784-90. 2005
    ..N-type calcium channels are a putative pre-synaptic target for these agents. We tested whether N-type calcium channels were sensitive to isoflurane and xenon and whether there was any stereoselectivity in the effect of isoflurane...
  69. ncbi Hemodynamic and catecholamine response to a rapid increase in isoflurane or sevoflurane concentration during a maintenance phase of anesthesia in humans
    Tomoki Nishiyama
    Department of Anesthesiology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Anesth 19:213-7. 2005
    ..The purpose of this study was to compare hemodynamic and catecholamine changes due to a sudden increase in inhalation anesthetic concentrations (isoflurane and sevoflurane) during surgery...
  70. ncbi Local cerebral blood flow, local cerebral glucose utilization, and flow-metabolism coupling during sevoflurane versus isoflurane anesthesia in rats
    C Lenz
    Department of Anesthesiology, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany
    Anesthesiology 89:1480-8. 1998
    ..Compared to isoflurane, knowledge of local cerebral glucose utilization (LCGU) and local cerebral blood flow (LCBF) during sevoflurane anesthesia is limited...
  71. ncbi Approximate entropy as an electroencephalographic measure of anesthetic drug effect during desflurane anesthesia
    J Bruhn
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Germany
    Anesthesiology 92:715-26. 2000
    ..The authors investigated the dose-response relation of the EEG approximate entropy during desflurane anesthesia in comparison with spectral edge frequency 95, median frequency, and bispectral index...
  72. ncbi Volatile anesthetics depress glutamate transmission via presynaptic actions
    M B Maclver
    Department of Anesthesia, Stanford University School of Medicine, California, USA
    Anesthesiology 85:823-34. 1996
    ..Recent evidence for a presynaptic depression of glutamate release produced by volatile anesthetics prompted the current study of isoflurane and halothane effects on glutamate-mediated transmission in the mammalian central nervous system...
  73. ncbi A prospective multicentric trial for effectiveness and tolerance of a N2O/O2 premix used as a sedative drug
    Martine Hennequin
    J Clin Psychopharmacol 24:552-4. 2004
  74. ncbi Propofol: relation between brain concentrations, electroencephalogram, middle cerebral artery blood flow velocity, and cerebral oxygen extraction during induction of anesthesia
    Guy L Ludbrook
    Department of Anaesthesia and Intensive Care, Royal Adelaide Hospital, Adelaide University, North Terrace, Adelaide, South Australia 5000, Australia
    Anesthesiology 97:1363-70. 2002
    ..This study measured the brain uptake of propofol in humans and the simultaneous effects on electroencephalography, cerebral blood flow velocity (V(mca)), and cerebral oxygen extraction...
  75. ncbi The effects of nitrous oxide and oxygen on transient hyperemic response in human volunteers
    K J Girling
    University Department of Anaesthesia and Intensive Care, Queen s Medical Centre and City Hospital NHS Trust, Nottingham, United Kingdom
    Anesth Analg 89:175-80. 1999
    ..5+/-0.2 to 1.2+/-0.1) and the SA (from 1.0+/-0.1 to 0.8+/-0.1) (P<0.05 for all). We conclude that breathing 50% nitrous oxide in oxygen results in both a significant increase in MCA FV and impairment of transient hyperemic response...
  76. ncbi Positron emission tomography study of regional cerebral metabolism in humans during isoflurane anesthesia
    M T Alkire
    Department of Anesthesiology, University of California Irvine Medical Center, Orange 92668, USA
    Anesthesiology 86:549-57. 1997
    ..To examine this issue, the authors studied the effects of isoflurane anesthesia on human cerebral glucose metabolism using positron emission tomography (PET)...
  77. ncbi Three cases of PICU sedation with isoflurane delivered by the 'AnaConDa'
    Peter V Sackey
    Department of Anesthesiology, Karolinska University Hospital Solna, Stockholm, Sweden
    Paediatr Anaesth 15:879-85. 2005
    ..Inhaled sedation of isoflurane with AnaConDa was effective in these patients. It may provide an alternative in difficult cases needing prolonged sedation and should be evaluated further...
  78. pmc Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear
    James M Sonner
    Department of Anesthesiology, University of California, San Francisco, San Francisco, California, USA
    Mol Pharmacol 68:61-8. 2005
    ..These results indicate that alpha1-containing GABA(A)-Rs in the hippocampus, amygdala, and/or cortex influence the amnestic effects of inhaled anesthetics and may be an important molecular target of the drug isoflurane...
  79. ncbi The effect of inhalational anaesthetics on QTc interval
    A H Karagoz
    Hacettepe University, Faculty of Medicine, Department of Anaesthesiology and Reanimation, Ankara, Turkey
    Eur J Anaesthesiol 22:171-4. 2005
    ..The aim of this study was to assess time dependent cumulative effects of three different inhalation anaesthetics on QTc interval during the maintenance of anaesthesia...
  80. ncbi Hypotensive anesthesia and recovery of cognitive function in long-term craniofacial surgery
    Valentina Caverni
    Department of Anesthesiology and Resuscitation, Umberto I Polyclinic, La Sapienza University, Rome, Italy
    J Craniofac Surg 16:531-6. 2005
    ..Early and late recovery were faster and more complete in the D group; P < 0.05. Postoperative morbidity (nausea, vomiting, shivering, pain, and edema) was slight and did not significantly differ among the groups...
  81. ncbi Postoperative pain and analgesic requirements after anesthesia with sevoflurane, desflurane or propofol
    Argyro Fassoulaki
    Department of Anesthesiology, Aretaieio Hospital, 76 Vassilissis Sofias Ave, 11527, Athens, Greece
    Anesth Analg 107:1715-9. 2008
    ....
  82. ncbi Dental anaesthesia in a patient with Noonan syndrome
    C H Ng
    Br J Oral Maxillofac Surg 43:267-8. 2005
  83. ncbi Pressure support ventilation with the ProSeal laryngeal mask airway. A comparison of sevoflurane, isoflurane and propofol
    C Keller
    Leopold Franzens University, Department of Anesthesia and Intensive Care Medicine, Innsbruck, Austria
    Eur J Anaesthesiol 22:630-3. 2005
    ..We compared propofol, sevoflurane and isoflurane for maintenance of anaesthesia with the ProSeal laryngeal mask airway during pressure support ventilation...
  84. ncbi Sevoflurane-remifentanil vs isoflurane-remifentanil for the surgical correction of craniosynostosis in infants
    Domenico Pietrini
    Department of Anesthesiology, Pediatric Neuroanesthesiology, Catholic University Medical School, Rome, Italy
    Paediatr Anaesth 15:653-62. 2005
    ..The aim of the present study was to compare the efficacy of isoflurane-remifentanil and sevoflurane-remifentanil combinations during neurosurgical correction craniosynostosis...
  85. ncbi Comparison of isoflurane and sevoflurane anesthesia after premedication with butorphanol in the green iguana (Iguana iguana)
    Sonia M Hernandez-Divers
    Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    J Zoo Wildl Med 36:169-75. 2005
    ..The cardiopulmonary effects of butorphanol-isoflurane and butorphanol-sevoflurane assessed in this study are similar, and both inhalants appear to be safe and effective for induction and maintenance in the green iguana...
  86. ncbi Effects of halothane, isoflurane, and sevoflurane on lipid peroxidation following experimental closed head trauma in rats
    A Yurdakoc
    Department of Anaesthesiology, Kirklareli Hospital, Edirne, Turkey
    Acta Anaesthesiol Scand 52:658-63. 2008
    ..In a rat closed head trauma model we examined both the time course of lipid peroxidation and the effects of halothane, isoflurane, and sevoflurane on it by analysis of malondialdehyde (MDA) formation...
  87. ncbi Remifentanil-propofol in vertebral disk operations: hemodynamics and recovery versus desflurane-n(2)o inhalation anesthesia
    Muhammet Gozdemir
    Ataturk Research and Training Hospital, Department of Anesthesiology, Ankara, Turkey
    Adv Ther 24:622-31. 2007
    ..Because of the lack of residual analgesic effects, postoperative analgesic treatment should be initiated immediately in patients undergoing TIVA...
  88. ncbi Protective effects of volatile agents against acetylcholine-induced bronchoconstriction in isolated perfused rat lungs
    E Lele
    Anaesthesiological Investigations Unit, University of Geneva, Geneva, Switzerland
    Acta Anaesthesiol Scand 50:1145-51. 2006
    ....
  89. ncbi Effects of halothane, sevoflurane and desflurane on the force-frequency relation in the dog heart in vivo
    Benedikt Preckel
    Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Postbus 22660 H1Z 139, 1100 DD Amsterdam, The Netherlands
    Can J Anaesth 53:1118-25. 2006
    ..We hypothesized that frequency potentiation is altered by volatile anesthetics and investigated the influence of halothane (H), sevoflurane (S) and desflurane (D) on the positive staircase phenomenon in dogs in vivo...
  90. ncbi The effect of nitrous oxide on halothane, isoflurane and sevoflurane requirements in ventilated dogs undergoing ovariohysterectomy
    T Duke
    Department Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada
    Vet Anaesth Analg 33:343-50. 2006
    ..To examine the effect of 64% nitrous oxide (N2O) on halothane (HAL), isoflurane (ISO) or sevoflurane (SEV) requirements in dogs undergoing ovariohysterectomy...
  91. ncbi Differences in need for hemodynamic support in horses anesthetized with sevoflurane as compared to isoflurane
    Bernd Driessen
    Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, Section of Critical Care Anesthesia, University of Pennsylvania, PA 19348, USA
    Vet Anaesth Analg 33:356-67. 2006
    ..To study whether hemodynamic function in horses, particularly mean arterial blood pressure (MAP), is better maintained with sevoflurane than isoflurane, thus requiring less pharmacological support...
  92. ncbi The effect of halothane, isoflurane, sevoflurane and propofol infusion on renal function after coronary artery bypass surgery
    Fatma Saricaoglu
    Hacettepe University, Department of Anesthesia and Reanimation, Ankara, Turkey
    Middle East J Anaesthesiol 18:955-64. 2006
    ..It is concluded that, halothane, isoflurane, sevoflurane and propofol infusion anesthesia as part of anesthesia maintenance for elective coronary artery bypass surgery does not affect early postoperative renal functions...
  93. ncbi [Is entropy a monitor for the guidance of intraoperative analgesia?]
    E Dierckens
    clinique d anesthésie réanimation, Hopital Huriez, CHRU de Lille, rue Michel Polonowski, 59037 Lille Cedex, France
    Ann Fr Anesth Reanim 26:113-8. 2007
    ..Comparison between BIS (Bispectral Index) and state (SE) and response (RE) entropy during laparotomy for inflammatory bowel disease patients (IBD) and evaluation of the variations of RE and SE during nociceptive stimulation...
  94. ncbi Comparison of sevoflurane and isoflurane in OPCAB surgery
    B G Venkatesh
    Department of Anaesthesiology and Critical Care, Escorts Heart Institute and Research Centre, New Delhi
    Ann Card Anaesth 10:46-50. 2007
    ..We conclude that sevoflurane and isoflurane can both be safely used in OPCAB surgery, but the awakening and extubation times are significantly less with sevoflurane...
  95. ncbi Inhalation anesthesia in Dumeril's monitor (Varanus dumerili) with isoflurane, sevoflurane, and nitrous oxide: effects of inspired gases on induction and recovery
    Mads F Bertelsen
    Toronto Zoo, 361A Old Finch Avenue, Scarborough, Ontario, Canada
    J Zoo Wildl Med 36:62-8. 2005
    ..There were no significant differences in recovery times between isoflurane and sevoflurane or between sevoflurane in 100% O2 and sevoflurane combined with N2O. Similar recovery times were observed in animals recovering in 100 and 21% O2...
  96. ncbi A study of the effect of hemorrhage on the cardiorespiratory actions of halothane, isoflurane and sevoflurane in the dog
    Francisco J Teixeira Neto
    Department of Veterinary Surgery and Anesthesia, Faculdade de Medicina Veterinaria e Zootecnia, Universidade Estadual Paulista, Botucatu, Sao Paulo, Brazil
    Vet Anaesth Analg 34:107-16. 2007
    ..To compare the cardiorespiratory changes induced by equipotent concentrations of halothane (HAL), isoflurane (ISO) and sevoflurane (SEVO) before and after hemorrhage...
  97. ncbi Cost minimisation and cost effectiveness in anaesthesia for total hip replacement surgery, in Belgium? A study comparing three general anaesthesia techniques
    J L Demeere
    Kliniek St Jan Brussels, Belgium
    Acta Anaesthesiol Belg 57:145-51. 2006
    ..Cost minimisation based on anaesthetic medication is ridiculously by small considering the total cost of the procedure...
  98. ncbi Differential effects of volatile and intravenous anesthetics on the activity of human TASK-1
    C Putzke
    Department of Anesthesiology and Critical Care Medicine, Philipps University Marburg, Baldingerstrasse 1, 35043, Marburg, Germany
    Am J Physiol Cell Physiol 293:C1319-26. 2007
    ..In contrast, stimulatory effects of sevoflurane and enantiomeric isoflurane on human TASK-1 can be observed at clinically relevant concentrations...
  99. ncbi [Specific features of anesthesia for primary surgery in children with facial and palatal clefts: retrospective study in 93 children at the Besançon University Hospital]
    M Brix
    Rev Stomatol Chir Maxillofac 107:126-8. 2006
  100. ncbi Evaluation of induction characteristics and hypnotic potency of isoflurane and sevoflurane in healthy dogs
    Erik H Hofmeister
    Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Am J Vet Res 69:451-6. 2008
    ..To determine induction characteristics and the minimum alveolar concentration (MAC) at which consciousness returned (MACawake) in dogs anesthetized with isoflurane or sevoflurane...
  101. ncbi [Low flow anaesthesia with isoflurane and sevoflurane in the dog]
    Sabine Kramer
    Klinik für Kleintiere, Stiftung Tierarztliche Hochschule Hannover
    Berl Munch Tierarztl Wochenschr 121:53-65. 2008
    ..Even considering that sevoflurane is more expensive than isoflurane, the use of the low flow technique decreases the cost of anaesthesia due to the reduced volatile anaesthetic consumption...

Research Grants62

  1. Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
    THOMAS JAY EBERT; Fiscal Year: 2013
    ..These studies will carefully describe the effects of glucose and statins on the function of the lining of blood vessels in humans. This new knowledge might lessen unwanted side effects related to diabetes. ..
  2. Cellular Mechanisms of Vasoregulation by Volatile Anesthetics
    Rostislav Bychkov; Fiscal Year: 2012
    ..provided by applicant): Two-pore-domain K+channels (K2P-channels) represent targets for actions of inhalation anesthetics on neurons...
  3. Genomics and pharmacodynamics of statin-related rhabdomyolysis
    Bruce M Psaty; Fiscal Year: 2013
    ..For some people, statins may be the equivalent of fluorinated- inhalation anesthetics, which precipitate malignant hyperthermia (MH) in susceptible individuals...
  4. GENERAL ANESTHETICS AND CLONED VOLTAGE-GATED CHANNELS
    ANA CORREA; Fiscal Year: 2000
    ..The specific aims are: 1) To characterize the action of general inhalation anesthetics on the macroscopic gating and conductance properties of cloned voltage-gated ion channels...
  5. MYOCARDIAL ISCHEMIA INDUCED BY INHALED ANESTHETICS
    CHARLES BUFFINGTON; Fiscal Year: 1993
    ..There is accumulating evidence that halothane and isoflurane, the major inhalation anesthetics in use today, differ in their effects on coronary vessels and platelets and thus differ in their tendency ..
  6. Role of Anesthetic Isoflurane in Alzheimer's Disease: In Vivo Investigation
    Zhongcong Xie; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE The proposed research will determine potential neurotoxic effects of inhalation anesthetics isoflurane, sevoflurane and desflurane in inducing cell death and increasing amyloid-b protein in mice and ..
  7. ACTION OF INHALED ANESTHETICS ON SYNAPTIC RECEPTORS
    Howard Wang; Fiscal Year: 1991
    ..If this hypothesis is correct, one can expect to observe specific binding of inhalation anesthetics to synaptic receptors...
  8. INTERFACIAL ACTION OF INHALATION ANESTHETICS
    Issaku Ueda; Fiscal Year: 1992
    ..The microscopic properties are measured by nuclear magnetic resonance spectroscopy, fluorescence spectrophotometry, Raman and Fourier-transform infrared spectroscopy, etc...
  9. BIOLOGICAL EFFECTS OF NITROUS OXIDE USED IN DENTISTRY
    A Verrusio; Fiscal Year: 1980
    ....
  10. SITES AND MECHANISMS OF INHALED ANESTHETIC ACTIONS
    EDMOND EGER; Fiscal Year: 2008
    ..abstract_text> ..
  11. BRAIN AND SPINAL CORD CONTRIBUTIONS TO ANESTHETIC ACTION
    JOSEPH ANTOGNINI; Fiscal Year: 2005
    ..This information will aid the development of newer and safer anesthetics, as well as lead to clinically useful means of modulating the neurotransmitter systems that are themselves modulated by anesthetics. ..
  12. ANESTHETIC EFFECTS ON SENSORIMOTOR INTEGRATION
    JOSEPH ANTOGNINI; Fiscal Year: 2009
    ..Understanding how and where anesthetics act will eventually lead to the development of better and safer anesthetics, thereby decreasing peri-operative morbidity and mortality and improving public health. ..
  13. Genes Underlying the Response to Inhaled Anesthetics
    James Sonner; Fiscal Year: 2008
    ....
  14. ANESTHETIC RENAL METABOLISM--MECHANISMS AND CONSEQUENCES
    Evan Kharasch; Fiscal Year: 2002
    ..More broadly, resulting biochemical and clinical insights will be applicable to the numerous other nephrotoxic haloalkenes that are ubiquitous environmental contaminants. ..
  15. Novel noninvasive assessment of cytochrome P450 activity
    Evan Kharasch; Fiscal Year: 2009
    ..This approach may identify inter-individual variability in drug disposition and response;permit more individualized dosing, and reduces the cost of drug interaction studies. ..
  16. Volatile Anesthetic Action in Vertebrate Locomotor Systems
    Steven L Jinks; Fiscal Year: 2010
    ..Results from these projects will increase our understanding of how and where anesthetics act in the nervous system, contributing to the development of safer anesthetics and clinical practices. ..
  17. INHALATIONAL ANESTHETIC BINDING STUDIES
    Roderic Eckenhoff; Fiscal Year: 2007
    ..abstract_text> ..
  18. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2006
    ..abstract_text> ..
  19. Interaction of amyloid beta and inhaled anesthetics
    Roderic Eckenhoff; Fiscal Year: 2006
    ..These studies will provide the feasibility to extend this hypothesis to animal models and ultimately to clinical studies of the interaction between anesthetics and neurodegeneration. ..
  20. General Anesthetics and nAcCHOR Agonist Affinity
    Douglas Raines; Fiscal Year: 2004
    ....
  21. AGE RELATED CARDIAC SENSITIVITY TO VOLATILE ANESTHETICS
    Y S Prakash; Fiscal Year: 2001
    ....
  22. COMPARING THREE ELECTRODE PLACEMENTS TO OPTIMIZE ECT
    Keith Rasmussen; Fiscal Year: 2005
    ..The results of this study will promote more effective and safer treatment of the most severely ill depressed patients. ..
  23. VOLATILE ANESTHETICS IN PRESSURE OVERLOAD HYPERTROPHY
    James Hannon; Fiscal Year: 2002
    ....
  24. Mechanisms of experimental drug-induced hepatitis
    Dolores Njoku; Fiscal Year: 2007
    ..3) To confirm antigenic spread in TFA-CYP2E1-immunized mice using spleenocyte proliferation assays stimulated with ERp58 and ASGPR and analyzed as in Specific Aim 2. [unreadable] [unreadable] [unreadable] [unreadable]..
  25. Intracellular signaling in anesthetic and hypoxic preconditioning of neurons
    Philip E Bickler; Fiscal Year: 2010
    ..The work will also identify why the aging brain may not be able to benefit from the neuroprotective actions of anesthetics or other preconditioning treatments. ..
  26. ANESHETIC MODULATION OF NATIVE NICOTINIC RECEPTORS
    Pamela Flood; Fiscal Year: 2003
    ..The resulting information will provide understanding of the molecular mechanism underlying one of the anesthetic effects that limit anesthetic safety. ..
  27. MECHANISMS OF ANESTHETIC ACTION ON SMOOTH MUSCLE
    JUDY SU; Fiscal Year: 2004
    Description (provided by applicant): Inhalation anesthetics simultaneously cause vasoconstriction and vasodilation in different vascular beds...
  28. Cerebral Edema in Pediatric Diabetic Ketoacidosis
    MONICA VAVILALA; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  29. BACKGROUND POTASSIUM CHANNELS AS ANESTHETIC TARGETS
    CHARLES YOST; Fiscal Year: 2008
    ..An understanding of the basic mechanisms underlying anesthesia has the potential to lead to improved anesthetic drugs or techniques. ..
  30. Gaq modulation of neuronal K+ channels: novel mechanisms and targets
    Douglas A Bayliss; Fiscal Year: 2011
    ..These experiments will characterize molecular substrates underlying native neuronal neurotransmitter-modulated background K+ currents and examine molecular mechanisms by which they are modulated. ..
  31. Hemodynamics and Outcome in Pediatric Brain Injury
    MONICA VAVILALA; Fiscal Year: 2007
    ..The proposed research will be carried out at the University of Washington, well-known known for mentored patient-oriented research. ..
  32. VOLATILE ANESTHETIC ACTION ON CARDIAC K CHANNELS
    Wai Meng Kwok; Fiscal Year: 2008
    ..This novel approach to anesthetic interaction with ion channels will have functional significance in the diseased myocardium where up- and downregulation of channel subunits are known to occur. ..
  33. Mechanisms of peripheral vascular anesthetic sensitivity
    THOMAS STEKIEL; Fiscal Year: 2008
    ..Additionally, this model also greatly facilitates development of congenic sub strains (partial chromosomal substitutions) for use in subsequent genetic mapping studies. ..
  34. ANESTHESIA AND COCAINE INDUCED CNS EXCITOTOXICITY
    ROBERT WHITTINGTON; Fiscal Year: 2003
    ..This award will allow me to obtain the investigational skills and knowledge base that will enable me to develop into a clinician-scientist and independent investigator in anesthesiology and neuroscience research. ..
  35. CELLULAR/MOLECULAR MECHANISMS OF GIRK CHANNEL INHIBITION
    DOUGLAS BAYLISS; Fiscal Year: 2003
    ..abstract_text> ..
  36. Estrogen and the Aging Blood Brain Barrier
    OAK CHI; Fiscal Year: 2002
    ..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
  37. Structure of the Glycine Receptor's Alcohol Binding Site
    INGRID LOBO; Fiscal Year: 2003
    ..abstract_text> ..
  38. POTASSIUM CHANNEL ACTIVATION BY VOLATILE ANESTHETICS
    CHARLES YOST; Fiscal Year: 2002
    ..Studies will be carried out in cerebellar granule neurons using whole cell ruptured patch and excised patch techniques on neurons in culture and in thin slices. ..
  39. PERINATAL HYPOXIA: ADRENOCORTICAL-METABOLIC ADAPTATIONS
    Hershel Raff; Fiscal Year: 2006
    ..Characterization of the hypothalamic-pituitary-adrenal and metabolic adaptations to perinatal hypoxia can lead to new diagnostic approaches and therapies to minimize morbidity and mortality. ..
  40. ARRAY SCREENING FOR LESCH NYHAN DISEASE
    Theodore Friedmann; Fiscal Year: 2002
    ..3. filter and chip array screening can identify individual genes and patterns of genes whose expression is modulated by HPRT expression. ..
  41. Ischemic Spasticity: Modulation by GAD65 Gene Delivery
    Martin Marsala; Fiscal Year: 2010
    ....
  42. Kinetics of Ligand Binding to Synaptic Ion Channels
    JAMES DILGER; Fiscal Year: 2006
    ..4. Use isothermal titration calorimetry to measure the thermodynamics of ligand binding to acetylcholine binding protein - a water soluble protein whose structure is being used as a template for the acetylcholine receptor. ..
  43. Biobehavioral Heterogeneity of Crack Cocaine Dependence
    Leslie Prichep; Fiscal Year: 2003
    ..Application of new mathematical algorithms will permit identification of the most probable neuroanatomical sources generating the QEEG, which may improve understanding of underlying mechanisms and help target new medications. ..
  44. GENE TRANSFER TO THE VASCULAR ENDOTHELIUM
    Theodore Friedmann; Fiscal Year: 2003
    ..Finally, we propose to characterize the biodistribution of these targeted vectors by sensitive fluorescence methods and correlate vector attachment with sites of endothelial-specific gene expression. ..
  45. SITES OF ACTION OF INHALATIONAL ANESTHETICS ON HPV
    James Baumgardner; Fiscal Year: 2001
    ..Understanding the sites of anesthetic action is of fundamental importance but may also lead to improved patient management. ..
  46. Does spinal manipulation speed determine neural response
    Joel Pickar; Fiscal Year: 2002
    ..Teaching the manual skill of spinal manipulation could be approached from the perspective of quantifying the velocity with which the clinician applies a spinal manipulation. ..
  47. The role of the TM2-TM3 linker in ethanol modulation of the Glycine Receptor
    MICHELLE DUPRE; Fiscal Year: 2008
    ..Additionally, because glycine shares homology with other cys-loop ion channels, including GABAA, nicotinic acetylcholine, and serotonin-3 receptors, [unreadable] [unreadable] [unreadable]..
  48. New PET Radiotracers-Monoamine Transporters
    Michael Kilbourn; Fiscal Year: 2003
    ....
  49. Signal Transduction Mechanisms in Neuroendocrine Neurons
    Arshad Khan; Fiscal Year: 2006
    ..This training will further my career goal of studying cellular signaling using an in vivo approach. ..
  50. Microarray analysis of neuronal ischemic preconditioning
    Piyush Patel; Fiscal Year: 2007
    ..A substantial benefit of the research will be the identification of novel therapeutic targets upon which future drug development can be based. ..
  51. Cognitive Function After Intracranial Aneurysm Surgery
    Satwant Samra; Fiscal Year: 2005
    ..Information gained from this investigation will be important in giving a prognosis for returning back to work as well as planning rehabilitation of patients suffering from aneurysmal SAH in future. ..
  52. PKC modulation of calcium current and anesthetic action
    GANESAN KAMATCHI; Fiscal Year: 2007
    ..abstract_text> ..
  53. AGING AND PERIOPERATIVE OUTCOMES
    JACQUELINE LEUNG; Fiscal Year: 2005
    ..We believe that our studies will provide important results contributing ultimately to the improvement of perioperative outcomes in geriatric patients. ..
  54. Ischemic Paraplegia: Modulation by Stem Cell Implant
    Martin Marsala; Fiscal Year: 2005
    ....
  55. Na+/H+ EXCHANGER AND CARDIAC HYPOTHERMIA: ROLE ROS
    Amadou Camara; Fiscal Year: 2007
    ..Emphasis will be placed on the effects of drug-induced blockade of mitochondrial ROS formation, NHE activity and KAav channel opening on cellular cation balance and mitochondrial bioenergetics. ..
  56. Developmental Psychobiology Symposia
    April Ronca; Fiscal Year: 2007
    ..abstract_text> ..
  57. Methods for in vivo behavioral observation of the mouse fetus
    April Ronca; Fiscal Year: 2008
    ..Ultimately, the application of these methods will increase our knowledge about developmental disabilities that will allow their prevention, prenatal detection, and cure. [unreadable] [unreadable] [unreadable]..
  58. The Effect of Sedation on Restorative Sleep
    Avery Tung; Fiscal Year: 2005
    ..Knowledge from this proposal will provide scientific insight into the relationships between anesthesia and sleep, and may lead to more effective clinical use of ICU sedatives. ..