Genomes and Genes
Summary: Agents that are capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general anesthesia, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.
Publications246 found, 100 shown here
- Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patientsDeborah P Saunders
Department of Dental Oncology, North East Cancer Center, Health Sciences North, Sudbury, Ontario, Canada
Support Care Cancer 21:3191-207. 2013The aim of this project was to develop clinical practice guidelines on the use of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the prevention and management of oral mucositis (OM) in cancer patients.
- Effects of common anesthetics on eye movement and electroretinogramGovind Nair
Yerkes Imaging Center, Neuroscience Division, Emory University, Atlanta, GA, USA
Doc Ophthalmol 122:163-76. 2011..Eye movement and drift, however, could limit high spatial resolution imaging, and anesthetics that minimize eye movement could significantly attenuate retinal function...
- Comparative efficacy of tricaine methanesulfonate and clove oil for use as anesthetics in red pacu (Piaractus brachypomus)K K Sladky
Environmental Medicine Consortium, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
Am J Vet Res 62:337-42. 2001..Care must be taken when using high concentrations of eugenol for induction, because ventilatory failure may occur rapidly. In addition, analgesic properties of eugenol are unknown...
- Direct activation of sleep-promoting VLPO neurons by volatile anesthetics contributes to anesthetic hypnosisJason T Moore
Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
Curr Biol 22:2008-16. 2012Despite seventeen decades of continuous clinical use, the neuronal mechanisms through which volatile anesthetics act to produce unconsciousness remain obscure...
- The impact of anesthetics and hyperoxia on cortical spreading depressionChiho Kudo
Department of Radiology, Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Exp Neurol 212:201-6. 2008..Various combinations of anesthetics and ambient conditions have been used by different laboratories making comparisons problematic and differences ..
- Anesthetics rapidly promote synaptogenesis during a critical period of brain developmentMathias De Roo
Department of Neuroscience, Faculty of Medicine, University of Geneva, Geneva, Switzerland
PLoS ONE 4:e7043. 2009..Since general anesthetics are powerful pharmacological modulators of neuronal activity, an important question is whether and how these ..
- Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESKBharat Keshavaprasad
Department of Anesthesia and Perioperative Care, University of California San Francisco, 513 Parnassus Ave, Room s 261, Box 0542, San Francisco, California 94143, USA
Anesth Analg 101:1042-9, table of contents. 2005..Amide local anesthetics inhibited the rodent TRESKs at almost 10-fold smaller concentrations than that which inhibit human TRESK...
- The common chemical motifs within anesthetic binding sitesEdward J Bertaccini
Department of Anesthesia, Stanford University School of Medicine, Stanford, California, USA
Anesth Analg 104:318-24. 2007..However, there are x-ray crystal structures in which anesthetics are complexed with proteins that are not directly related to anesthetic action...
- Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channelYun Weng
Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0464, USA
Anesth Analg 110:59-63. 2010..We report its modulation by 9 anesthetics using 2-electrode voltage clamping in Xenopus laevis oocytes...
- Anesthetic-related cardiac arrest and its mortality: a report covering 72,959 anesthetics over 10 years from a US teaching hospitalMyrna C Newland
Department of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 4455, USA
Anesthesiology 97:108-15. 2002....
- Consciousness and anesthesiaMichael T Alkire
Department of Anesthesiology and The Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA 92868, USA
Science 322:876-80. 2008..For instance, certain anesthetics act on areas of the brain's cortex near the midline and abolish behavioral responsiveness, but not necessarily ..
- Drugs of anaesthesia and cancerLetterio B Santamaria
Department of Neurosciences, Psychiatric and Anesthesiological Sciences, University of Messina, Via C Valeria, Messina, Italy
Surg Oncol 19:63-81. 2010..This kind of knowledge could be a basic valuable support to improve anaesthesia performance and patient safety...
- Anesthetics and tau protein: animal model studiesXiaoqin Run
Department of General Surgery, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China
J Alzheimers Dis 22:49-55. 2010..An understanding of the mechanism will help develop strategies for preventing or eliminating this adverse effect of anesthesia...
- Prevalence of malignant hyperthermia and relationship with anesthetics in Japan: data from the diagnosis procedure combination databaseMasahiko Sumitani
Department of Anesthesiology and Pain Relief Center, University of Tokyo Hospital, Tokyo, Japan
Anesthesiology 114:84-90. 2011..The actual prevalence of MH remains unclear, and the association between MH and various anesthetic drugs remains controversial because of a lack of universal reporting...
- Regulatory role of anesthetics on heme oxygenase-1Alexander Hoetzel
University Medical Center Freiburg, Department of Anesthesiology and Critical Care Medicine, Freiburg, Germany
Curr Drug Targets 11:1495-503. 2010..In recent studies, intravenous and inhaled anesthetics (e.g., ketamine, propofol, opioids, isoflurane, sevoflurane, desflurane, etc...
- Anesthetics impact the resolution of inflammationNan Chiang
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 3:e1879. 2008Local and volatile anesthetics are widely used for surgery. It is not known whether anesthetics impinge on the orchestrated events in spontaneous resolution of acute inflammation...
- Physiologic and biochemical measurements and response to noxious stimulation at various concentrations of MS-222 in koi (Cyprinus carpio)Jonathan Stockman
William R Pritchard Veterinary Medical Teaching Hospital VMTH, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Vet Anaesth Analg 40:35-47. 2013..To evaluate the physiological effect and response to noxious stimulation at five concentrations of MS-222 in koi (Cyprinus carpio)...
- Densities of dextrose-free intrathecal local anesthetics, opioids, and combinations measured at 37 degrees CM G Richardson
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, New York, NY 14642, USA
Anesth Analg 84:95-9. 1997..Densities of dextrose-free solutions of local anesthetics and opioids, and commonly used anesthetic/opioid mixtures were determined at 37...
- Promiscuous ligands and attractive cavities: how do the inhaled anesthetics work?R G Eckenhoff
Department of Anesthesiology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
Mol Interv 1:258-68. 2001The inhaled anesthetics were officially introduced to American medicine more than 160 years ago and rank among the most important medical advances in our time...
- Activity regulates programmed cell death of zebrafish Rohon-Beard neuronsK R Svoboda
Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Development 128:3511-20. 2001..The results indicate that electrical activity provides signals that are required for the normal elimination of Rohon-Beard cells...
- Daily rhythms of toxicity and effectiveness of anesthetics (MS222 and eugenol) in zebrafish (Danio rerio)Francisco J Sánchez-Vázquez
Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain
Chronobiol Int 28:109-17. 2011..zebrafish were kept under a 12 h:12 h light-dark (LD) cycle and exposed to different concentrations of the anesthetics for 15 min at ML or MD...
- Increasing the depth of anesthesia assessmentIead Rezek
Imperial College London
IEEE Eng Med Biol Mag 26:64-73. 2007
- Hemodynamics of anesthetized ventilated mouse models: aspects of anesthetics, fluid support, and strainCoert J Zuurbier
Department of Anaesthesiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
Am J Physiol Heart Circ Physiol 282:H2099-105. 2002..No differences in HR for the three anesthetics were observed for the BalbC strain...
- A clinical prospective comparison of anesthetics sensitivity and hemodynamic effect among patients with or without obstructive jaundiceL Q Yang
Department of Anesthesiology, The Second Military Medical University, Shanghai, China
Acta Anaesthesiol Scand 54:871-7. 2010..To compare isoflurane anesthesia in patients with or without hyperbilirubinemia undergoing hepatobiliary surgery...
- Ontogenetic changes in the toxicity and efficacy of the anaesthetic MS222 (tricaine methanesulfonate) in zebrafish (Danio rerio) larvaePeter J Rombough
Department of Zoology, Brandon University, Brandon, Manitoba, Canada R7A 6A9
Comp Biochem Physiol A Mol Integr Physiol 148:463-9. 2007..The implications of these ontogenetic changes in lethal and effective levels for researchers or others intending to use the anaesthetic with fish larvae are discussed...
- Weak intermolecular associations and anesthesiaCamille Sandorfy
Departement de Chimie, Universite de Montreal, Montreal, Quebec
Anesthesiology 101:1225-7. 2004
- [Serious intraoperative problems--a five-year review of 83,844 anesthetics]Sigurd Fasting
Department of Anesthesia and Intensive Care, St Olav s Hospital, University Hospital of Trondheim, Trondheim, Norway
Can J Anaesth 49:545-53. 2002..Using data from a simple routine-based system of problem reporting, we have analyzed the pattern and causes of serious non-fatal problems, in order to improve preventive strategies...
- A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anestheticsMandy L McCracken
Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, Texas 78712, USA
J Pharmacol Exp Ther 335:600-6. 2010Alcohols and inhaled anesthetics enhance the function of GABA(A) receptors containing α, β, and γ subunits...
- Immersion anaesthesia with tricaine methanesulphonate or propofol on different sizes and strains of silver catfish Rhamdia quelenL T Gressler
Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, 97105 900 Santa Maria, RS, Brazil
J Fish Biol 81:1436-45. 2012..quelen with MS222 or propofol bath solution in order to minimize physiological impact...
- Anesthetics and anesthesia techniques: impacts on perioperative management and postoperative outcomesBrian M Parker
Department of General Anesthesiology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Cleve Clin J Med 73:S13-7. 2006..Spinal and epidural anesthetics also produce significant physiologic changes...
- The impact of four different classes of anesthetics on the mechanisms of blood pressure regulation in normotensive and spontaneously hypertensive ratsM Bencze
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Physiol Res 62:471-8. 2013Most anesthetics induce characteristic hemodynamic changes leading to blood pressure (BP) reduction but the role of renin-angiotensin system (RAS), sympathetic nervous system (SNS) and nitric oxide (NO) synthesis in this BP reduction is ..
- A chronic implant to record electroretinogram, visual evoked potentials and oscillatory potentials in awake, freely moving rats for pharmacological studiesIrene Guarino
Istituto Superiore di Sanita, via Regina Elena 299, 00161 Roma, Italy
Neural Plast 11:241-50. 2004..In particular, the analysis of the variation of latency, amplitude, and spectral content of rapid oscillatory potentials could be important for a functional evaluation of the visual system in unanesthetized versus anesthetized animals...
- The immune system and the effects of non-volatile anesthetics on neutrophil transmigration through endothelial cell monolayersR Hofbauer
Department of Medical and Chemical Laboratory Diagnostics, Medical Intensive Care Unit, University of Vienna, Vienna, Austria
Curr Pharm Des 5:1015-27. 1999..In long-term mechanically ventilated critically ill patients, non-volatile anesthetics are needed over a prolonged time period...
- Blood gases and energy metabolites in mouse blood before and after cerebral ischemia: the effects of anestheticsTina M Schwarzkopf
Department of Pharmacology, University of Frankfurt College of Pharmacy, Max von Laue Str 9, 60438 Frankfurt, Germany
Exp Biol Med (Maywood) 238:84-9. 2013..We found that all of the injectable anesthetics tested (ketamine/xylazine, chloral hydrate, propofol and pentobarbital) caused a decrease in blood pH and ..
- The effects of anesthetics on chronic pain after breast cancer surgeryAh Reum Cho
Department of Anesthesia and Pain Medicine, School of Medicine, Pusan National University, Medical Research Institute, Pusan National University Hospital, Gudeok Ro, Seo Gu, Busan 602 739, Korea
Anesth Analg 116:685-93. 2013..In this study, we investigated the hypothesis that propofol would prevent the development and severity of chronic pain after breast cancer surgery, as in acute pain...
- Effects of different anesthetics on the paired-pulse depression of the h reflex in adult ratStephen M Ho
Developmental Neurobiology, Research School of Biological Sciences, Australian National University, Canberra, ACT 2601, Australia
Exp Neurol 177:494-502. 2002..its use in SCI, the excitability of the Hoffman reflex (H reflex) has been assessed under several commonly used anesthetics. The H reflex was recorded in the distal foot muscles (dorsal interossei) of adult rats, while the lateral ..
- Ketamine does not affect intestinal microcirculation in pentobarbital-anaesthetized rats during experimental endotoxaemiaCh Lehmann
Klinik für Anästhesiologie und Intensivmedizin, Ernst Moritz Arndt Universitat Greifswald, 17475 Greifswald, F Loeffler Str 23, Germany
Lab Anim 41:55-62. 2007..In rats, the combination of pentobarbital and ketamine is suitable for use during the study of intestinal microcirculation in experimental endotoxaemia...
- Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anestheticsJ E Kralic
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
J Pharmacol Exp Ther 305:600-7. 2003..of alpha1 subunit containing receptors to ethanol responses in comparison to neurosteroids and other anesthetics using GABA(A) receptor alpha1 subunit knockout mice...
- The young: neuroapoptosis induced by anesthetics and what to do about itCatherine E Creeley
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
Anesth Analg 110:442-8. 2010..However, recent reports provide mounting evidence that exposure of the immature animal brain to anesthetics during the period of rapid synaptogenesis, also known as the brain growth spurt period, triggers widespread ..
- General anesthetics and molecular mechanisms of unconsciousnessStuart A Forman
Department of Anaesthesia, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
Int Anesthesiol Clin 46:43-53. 2008
- Hypersensitivity reactions in the anesthesia setting/allergic reactions to anestheticsPaul M Mertes
CHU de Nancy, Service d Anesthésie Réanimation Chirurgicale, INSERM U 911 Groupe Choc, Hopital Central, Nancy, France
Curr Opin Allergy Clin Immunol 12:361-8. 2012..Immediate hypersensitivity reactions are an important cause for mortality and morbidity in anesthesia. The present review considers reports covering epidemiology, diagnosis, and treatment of these reactions...
- Two populations of layer v pyramidal cells of the mouse neocortex: development and sensitivity to anestheticsElodie Christophe
Neurophysiology and New Microscopies Laboratory, INSERM U603, CNRS FRE 2500, Universite Paris Descartes, 45 Rue des StPères, 75006 Paris, France
J Neurophysiol 94:3357-67. 2005..Together these results indicate that the two populations of layer V pyramidal neurons already start to differ during the first postnatal week and exhibit different firing capabilities after anesthesia...
- Mimosa pudica, Dionaea muscipula and anestheticsThiago Paes de Barros De Luccia
Department of Physiology, University of Sao Paulo Medical School, Sao Paulo, Brazil
Plant Signal Behav 7:1163-7. 2012Some studies showed that anesthetics reduce the response of physical stimuli in Mimosa pudica and in Venus Flytrap (Dionaea muscipula), peculiar plants that have the ability to respond to touch stimuli...
- Differential effects of anesthetics on cocaine's pharmacokinetic and pharmacodynamic effects in brainCongwu Du
Department of Anesthesiology, State University of New York at Stony Brook, Stony Brook, NY, USA
Eur J Neurosci 30:1565-75. 2009..Here we assessed the effects of two commonly used anesthetics [alpha-chloralose (alpha-CHLOR) and isofluorane (ISO)] on the effects of acute cocaine (1 mg/kg i.v...
- Transient effects of anesthetics on dendritic spines and filopodia in the living mouse cortexGuang Yang
Department of Anesthesiology, New York University Medical Center, New York, New York, USA
Anesthesiology 115:718-26. 2011b>Anesthetics are widely used to induce unconsciousness, pain relief, and immobility during surgery...
- Interactions of anesthetics with their targets: non-specific, specific or both?Bernd W Urban
Klinik fur Anasthesiologie und Operative Intensivmedizin, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, D 53127 Bonn, Germany
Pharmacol Ther 111:729-70. 2006..anesthetic? We shall review first what general anesthesia is all about and which drugs are being used as anesthetics. There is neither a unique definition of general anesthesia nor any consensus on how to measure it...
- Morphological transitions in model membrane systems by the addition of anestheticsMagdalene Baciu
Centre for Materials Science, Department of Physics, Astronomy, and Mathematics, University of Central Lancashire, Preston, PR1 2HE Lancashire, UK
J Phys Chem B 111:909-17. 2007..It has been proposed that anesthetics may have the effect of promoting pore formation across membranes or at least switching transmembrane channels...
- Postoperative mortality in children after 101,885 anesthetics at a tertiary pediatric hospitalBenjamin F van der Griend
Christchurch Hospital, Christchurch, New Zealand
Anesth Analg 112:1440-7. 2011..Our objective for this study was to determine the incidence of 24-hour and 30-day mortality after anesthesia and to determine the incidence and nature of anesthesia-related mortality in pediatric practice at a large tertiary institution...
- Isomap approach to EEG-based assessment of neurophysiological changes during anesthesiaJukka Kortelainen
Department of Electrical and Information Engineering, University of Oulu, Finland
IEEE Trans Neural Syst Rehabil Eng 19:113-20. 2011Increasing concentrations of anesthetics in the blood induce a continuum of neurophysiological changes, which reflect on the electroencephalogram (EEG)...
- The effects of volatile aromatic anesthetics on voltage-gated Na+ channels expressed in Xenopus oocytesTakafumi Horishita
Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, 1 University Station A4800, Austin, TX 78712, USA
Anesth Analg 107:1579-86. 2008Many inhaled anesthetics inhibit voltage-gated sodium channels at clinically relevant concentrations, and suppression of neurotransmitter release by these anesthetics results, at least partly, from decreased presynaptic sodium channel ..
- The intravenous anesthetics barbiturates inhibit hypoxia-inducible factor 1 activationTakuhiko Wakamatsu
Department of Anesthesia, Kyoto University Hospital, Kyoto University, Kyoto, Japan
Eur J Pharmacol 617:17-22. 2009Hypoxia-inducible factor 1 (HIF-1) is a master transcription factor of hypoxia-induced gene expression. Anesthetics and perioperative drugs have been reported to affect HIF-1 activity...
- Membrane structural perturbations caused by anesthetics and nonimmobilizers: a molecular dynamics investigationL Koubi
Center for Molecular Modeling, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA
Biophys J 81:3339-45. 2001..These contrasting perturbations of the lipid membrane caused by those quite similarly sized molecules may explain the difference in their physiological effects as anesthetics and nonimmobilizers, respectively.
- Anesthetics alter the physical and functional properties of the Ca-ATPase in cardiac sarcoplasmic reticulumB S Karon
Department of Biochemistry, University of Minnesota Medical School, Minneapolis 55455, USA
Biophys J 68:936-45. 1995..These results underscore the crucial role of protein-protein interactions on Ca-ATPase regulation and anesthetic perturbation of cardiac SR...
- Anesthetics and sedatives: toxic or protective for the developing brain?Christopher G Ward
Department of Anesthesia, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Pharmacol Res 65:271-4. 2012Despite our insufficient understanding of the exact molecular mechanisms of general anesthetics and sedatives, every year millions of children are treated with these drugs in a seemingly safe manner...
- Disruption of the circadian system by environmental factors: Effects of hypoxia, magnetic fields and general anesthetics agentsYvan Touitou
Unite de Chronobiologie, Fondation Ophtalmologique A de Rothschild, Paris, France
Adv Drug Deliv Rev 62:928-45. 2010..These factors are hypoxia, magnetic fields and anesthetic agents whose importance has to be considered...
- Mutations conferring new patterns of sensitivity to volatile anesthetics in Caenorhabditis elegansP G Morgan
Department of Anesthesiology, University Hospitals of Cleveland, Ohio
Anesthesiology 81:888-98. 1994..use of the nematode Caenorabditis elegans as a genetic model for studying the mechanism of action of volatile anesthetics. All previous strains of C...
- Using Elman recurrent neural networks with conjugate gradient algorithm in determining the anesthetic the amount of anesthetic medicine to be appliedRüştü Güntürkün
Department of Electronics, Dumlupinar University, Simav Kütahya, Turkey
J Med Syst 34:479-84. 2010....
- Neuroprotective properties of different anesthetics on axotomized rat retinal ganglion cells in vivoSidar Ozden
Neuroregeneration Laboratory, Department of Neurology, University of Jena, Jena, Germany
J Neurotrauma 21:73-82. 2004..GDNF) that rescues injured RGCs, to study if the anesthetics (A, B, E; see above) would influence the degree of RGC neuroprotection afforded by GDNF...
- A system for tracking changes in the mid-latency evoked potential during anesthesiaM Hansson
Department of Applied Electronics, Lund University, Sweden
IEEE Trans Biomed Eng 45:323-34. 1998..The procedure is based on inherent properties of the MLAEP and the noise. A simulation and examples of the performance on real data recorded during surgery are shown...
- General anesthetics and the developing brainGeorge K Istaphanous
Department of Anesthesia, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Curr Opin Anaesthesiol 22:368-73. 2009General anesthetics and sedatives are used in millions of children every year to facilitate surgical procedures, imaging studies, and sedation in operating rooms, radiology suites, emergency departments, and ICUs...
- Intravenous self-administration of abused solvents and anesthetics in miceElena A Blokhina
Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Leo Tolstoy Street, St Petersburg 197089, Russia
Eur J Pharmacol 485:211-8. 2004Volatile organic solvents, fuels and anesthetics are subject to abuse. The aim of the present study was to evaluate i.v...
- Anaphylaxis to general anestheticsD Anne Moneret-Vautrin
Department of Internal Medicine, Clinical Immunology and Allergology, Nancy, France
Chem Immunol Allergy 95:180-9. 2010The incidence of hypersensitivity reactions to anesthetics is estimated 1 in 13,000 anesthetics up to 1 in 3,180. The rate of mortality ranges between 3 and 9%. 90% of reactions appear at anesthesia induction...
- Anesthetics, immune cells, and immune responsesShin Kurosawa
Department of Anesthesiology and Intensive Care Medicine, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
J Anesth 22:263-77. 2008..Along with stress such as surgery, blood transfusion, hypothermia, hyperglycemia, and postoperative pain, anesthetics per se are associated with suppressed immunity during perioperative periods because every anesthetic has direct ..
- Is there a specific receptor for anesthetics? Contrary effects of alcohols and fatty acids on phase transition and bioluminescence of firefly luciferaseI Ueda
Anesthesia 112A, Department of Veterans Administration Medical Center, and University of Utah School of Medicine, Salt Lake City, Utah 84148 USA
Biophys J 75:1052-7. 1998..Eyring's unfolding theory (Science. 1966. 154:1609-1613) postulates that anesthetics and alcohols bind nonspecifically to interfacial areas of proteins and reversibly unfold the conformation...
- Somatosensory cortical neuronal population activity across states of anaesthesiaIrina A Erchova
Cognitive Neuroscience Sector, International School for Advanced Studies, Via Beirut, 9, 34014 Trieste, Italy
Eur J Neurosci 15:744-52. 2002..The possible significance of the cyclic cortical responsiveness encountered during urethane anaesthesia to cortical processing in awake rats is considered...
- The slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillatorsVincenzo Crunelli
School of Biosciences, Cardiff University, Cardiff, UK
Nat Neurosci 13:9-17. 2010....
- Hypersensitivity of the anesthesia-induced comatose brainDaniel Kroeger
Laboratoire de Neurophysiologie, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec, Canada G1J 2G3
J Neurosci 27:10597-607. 2007..These findings raise the issue of what burst spontaneity during anesthesia-induced coma means and opens new venues for the handling of comatose patients...
- Different actions of general anesthetics on the firing patterns of neocortical neurons mediated by the GABA(A) receptorB Antkowiak
Max Planck Institut für biologische Kybernetik, Tubingen, Germany
Anesthesiology 91:500-11. 1999In cultured slice preparations of rat neocortical tissue, clinically relevant concentrations of volatile anesthetics mainly decreased action potential firing of neurons by enhancing gamma-aminobutyric acid (GABA(A)) receptor-mediated ..
- Effects of anesthetics on mutant N-methyl-D-aspartate receptors expressed in Xenopus oocytesJunichi Ogata
University of Texas, Waggoner Center for Alcohol and Addiction Research, 1 University Station A4800, Austin, TX 78712 0159, USA, and Department of Anesthesia, Kyoto University Hospital, Japan
J Pharmacol Exp Ther 318:434-43. 2006Alcohols, inhaled anesthetics, and some injectable anesthetics inhibit the function of N-methyl-d-aspartate (NMDA) receptors, but the mechanisms responsible for this inhibition are not fully understood...
- Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouseMihail G Chelu
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
FASEB J 20:329-30. 2006..disorder characterized by skeletal muscle rigidity and elevated body temperature in response to halogenated anesthetics such as isoflurane or halothane...
- Correlating the clinical actions and molecular mechanisms of general anestheticsKen Solt
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
Curr Opin Anaesthesiol 20:300-6. 2007To summarize recent in-vitro and in-vivo research on molecular mechanisms of general anesthetics' actions.
- Free radicals, antioxidants, and neurologic injury: possible relationship to cerebral protection by anestheticsJohn X Wilson
Department of Physiology, University of Western Ontario, London, Ontario, Canada
J Neurosurg Anesthesiol 14:66-79. 2002..General anesthetics penetrate into brain parenchyma, where they may abrogate oxidative injury to neurons by several mechanisms that ..
- Optimization of intraperitoneal injection anesthesia in mice: drugs, dosages, adverse effects, and anesthesia depthM Arras
Institute of Laboratory Animal Science, Central Biological Laboratory, University of Zurich, Switzerland
Comp Med 51:443-56. 2001..g., embryo transfer/vasectomy) coupled with a simple method to assess anesthesia depth under routine laboratory conditions...
- Anesthesia for patients with congenital insensitivity to pain and anhidrosis: a questionnaire study in JapanToshiya Tomioka
Department of Anesthesiology, Faculty of Medicine, The University of Tokyo, Japan
Anesth Analg 94:271-4, table of contents. 2002..Although lacking pain sensation, some patients do have tactile hyperesthesia. Thus, anesthetics are a necessity during operations...
- Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptorsN Brown
Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
Br J Pharmacol 136:965-74. 2002..With its restricted distribution within the brain and unique pharmacology this receptor may play an important role in the action of neurosteroids and anaesthetics. British Journal of Pharmacology (2002) 136, 965-974..
- Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermiaEmmanuel Planel
Columbia University Medical Center, Department of Pathology, Taub Institute for Alzheimer s Disease Research, New York, New York 10032, USA
J Neurosci 27:3090-7. 2007..thus examined whether general anesthesia is associated with AD, with some studies suggesting that exposure to anesthetics may increase the risk of AD...
- Four-alpha-helix bundle with designed anesthetic binding pockets. Part I: structural and dynamical analysesDejian Ma
Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 15260, USA
Biophys J 94:4454-63. 2008..mimics the transmembrane domain of the Cys-loop receptor family believed to be the protein target for general anesthetics. Using high resolution NMR, we solved the structure (Protein Data Bank ID: 2I7U) of a prototypical dimeric four-..
- The effect of different anesthetics on neurovascular couplingMaria Angela Franceschini
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
Neuroimage 51:1367-77. 2010..Baseline cerebral blood flow (CBF) interacts with neural activity and influences the evoked hemodynamic responses. Finally, neurovascular coupling appears to be the same across all anesthetics used.
- Cortical inhibition during burst suppression induced with isoflurane anesthesiaJudy Fay Ferron
Department of Stomatology, School of Medical Dentistry, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
J Neurosci 29:9850-60. 2009..Thus cortical hyperexcitability during BS is favored by suppressed inhibition...
- Exposure to anaesthetic agents, cognitive functioning and depressive symptomatology in the elderlyM L Ancelin
INSERM EPI-9930, Epidemiology and Clinical Research in Nervous System Pathologies, CLRC Val d'Aurelle, Bat. Rech. Rdc, , 34298 Montpellier Cedex 5, France
Br J Psychiatry 178:360-6. 2001..CONCLUSIONS: Cognitive functions are not equally affected, type of impairment being determined by the risk factors described above and anaesthesia type...
- Anesthetic- and heat-induced sudden death in calsequestrin-1-knockout miceMarco Dainese
Ce S I Department of Basic and Applied Medical Sciences, Interuniversity Institute of Myology, University G D Annunzio, I 66013 Chieti, Italy
FASEB J 23:1710-20. 2009..These results demonstrate that CASQ1 deficiency alters proper control of RYR1 function and suggest CASQ1 as a potential candidate gene for linkage analysis in families with MH/EHS where mutations in the RYR1 gene are excluded...
- Inhalational anesthetic-binding proteins in rat neuronal membranesJin Xi
Department of Anesthesia, University of Pennsylvania Health System, 305 John Morgan, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
J Biol Chem 279:19628-33. 2004Molecular targets of inhaled anesthetics must be represented in the group that specifically bind these drugs, but the paucity of direct binding data has limited the number of candidates for further evaluation...
- Safety and efficacy of various combinations of injectable anesthetics in BALB/c miceSandra Buitrago
Department of Laboratory Animal Resources, Roswell Park Cancer Institute, Buffalo, NY, USA
J Am Assoc Lab Anim Sci 47:11-7. 2008..All anesthetic protocols produced significant hypotension. No deaths occurred. We recommend KXA as a safe and reliable anesthetic for mice requiring a surgical plane of anesthesia...
- Anesthetics and ion channels: molecular models and sites of actionT Yamakura
Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, Texas 78712, USA
Annu Rev Pharmacol Toxicol 41:23-51. 2001..the past several decades, a group of ligand-gated ion channels have emerged as plausible targets for general anesthetics. Molecular biology techniques have greatly accelerated attempts to classify ligand-gated ion channel ..
- Fluorinated groups mediate the immunomodulatory effects of volatile anesthetics in acute cell injuryMartin Urner
Institute of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
Am J Respir Cell Mol Biol 45:617-24. 2011Volatile anesthetics are known to attenuate inflammatory response and tissue damage markers in acute organ injury...
- A longitudinal study for investigating the exposure level of anesthetics that impairs neurobehavioral performanceMaria Luisa Scapellato
Department of Environmental Medicine and Public Health, University of Padova, Italy
Neurotoxicology 29:116-23. 2008There is conflicting evidence on the level of anesthetics that impairs neurobehavioral performance, leading to differences in exposure standards (25 or 50 ppm for N(2)O)...
- GABAA receptors, anesthetics and anticonvulsants in brain developmentOliver Henschel
Department of Neurosurgery, Yale University, New Haven, CT 06520 8082, USA
CNS Neurol Disord Drug Targets 7:211-24. 2008..Several GABAergic drugs have been commonly used as anesthetics, sedatives, and anticonvulsants for decades...
- The temperature dependence of lipid membrane permeability, its quantized nature, and the influence of anestheticsAndreas Blicher
Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark
Biophys J 96:4581-91. 2009..Further, we demonstrate that anesthetics lead to a change in membrane permeability that can be predicted from their effect on heat capacity profiles...
- General anesthetics inhibit cytochrome P450 monooxygenases and arachidonic acid metabolismF S LaBella
Department of Pharmacology and Therapeutics, University of Manitoba, Faculty of Medicine, Winnipeg, Man, Canada
Can J Physiol Pharmacol 71:48-53. 1993Identification of a specific biomolecular target appropriately sensitive to a wide array of anesthetics has been elusive...
- The effects of anesthetics on cortical spreading depression elicitation and c-fos expression in ratsY Kitahara
Department of Anesthesiology, Brain Research Institute, Niigata University School of Medicine, Japan
J Neurosurg Anesthesiol 13:26-32. 2001The effects of anesthetics on the generation of cortical spreading depression (CSD) were investigated. Volatile anesthetics halothane, isoflurane, sevoflurane (0.5, 1.0, and 2...
- General anesthetics potentiate gamma-aminobutyric acid actions on gamma-aminobutyric acidA receptors expressed by Xenopus oocytes: lack of involvement of intracellular calciumL H Lin
Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado
J Pharmacol Exp Ther 263:569-78. 1992..We asked whether the GABAA receptor is a target site common for general anesthetics that are chemically and structurally diverse...
- How anesthetics, neurotransmitters, and antibiotics influence the relaxation processes in lipid membranesHeiko M Seeger
The Niels Bohr Institute, University of Copenhagen, Blegdamsvej 17, 2100 Copenhagen Ø, Denmark
J Phys Chem B 111:13858-66. 2007..unilamellar and multilamellar vesicle systems with and without the addition of small molecules such as general anesthetics, neurotransmitters, and antibiotics. These drugs interact with membranes and affect melting points and profiles...
- Considerations for the use of anesthetics in neurotoxicity studiesSumedha W Karmarkar
Department of Pharmacology, School of Medicine, Southern Illinois University, Springfield, IL, USA
Comp Med 60:256-62. 2010b>Anesthetics are widely used in experiments investigating neurotoxicity and neuroprotection; however, these agents are known to interfere with the outcome of these experiments...
- Muscarinic signaling in the central nervous system. Recent developments and anesthetic implicationsM E Durieux
Department of Anesthesiology, University of Virginia Health Sciences Center, Charlottesville 22908, USA
Anesthesiology 84:173-89. 1996..The next years will doubtlessly see progress in this area, and our specialty may well reap the benefits...
- Anesthetics discriminate between tonic and phasic gamma-aminobutyric acid receptors on hippocampal CA1 neuronsMark C Bieda
Department of Anesthesia, Stanford University School of Medicine, SUMC S288, Stanford, CA 94305 5117, USA
Anesth Analg 108:484-90. 2009..Recent studies have indicated that anesthetics can enhance inhibition of CNS neurons by increasing current flow through tonic gamma-aminobutyric acid (GABA(A))..
- Atomic force microscopy to study interacting forces in phospholipid bilayers containing general anestheticsZoya V Leonenko
Department of Chemistry, University of Calgary, Alberta, Canada
Methods Mol Biol 400:601-9. 2007Atomic force microscopy (AFM) can be used to reveal intimate details about the effect of anesthetics on phospholipid bilayers...
- Neural pathways associated with loss of consciousness caused by intracerebral microinjection of GABA A-active anestheticsI Sukhotinsky
Department of Cell and Animal Biology, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Eur J Neurosci 25:1417-36. 2007..We hypothesize that barbiturate anesthetics and related agents microinjected into the MPTA enhance the inhibitory response of local GABA(A)-R-bearing ..
- HCN subunit-specific and cAMP-modulated effects of anesthetics on neuronal pacemaker currentsXiangdong Chen
Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
J Neurosci 25:5803-14. 2005General anesthetics have been a mainstay of surgical practice for more than 150 years, but the mechanisms by which they mediate their important clinical actions remain unclear...
- Differential subunit dependence of the actions of the general anesthetics alphaxalone and etomidate at gamma-aminobutyric acid type A receptors expressed in Xenopus laevis oocytesE Sanna
Department of Experimental Biology, University of Cagliari, Italy
Mol Pharmacol 51:484-90. 1997..composition of the gamma-aminobutyric acid (GABA) type A receptor on the multiple actions of the general anesthetics alphaxalone and etomidate were investigated...
- GAS-1: a mitochondrial protein controls sensitivity to volatile anesthetics in the nematode Caenorhabditis elegansE B Kayser
Department of Anesthesiology, University Hospitals and Case Western Reserve University, Cleveland, Ohio 44106, USA
Anesthesiology 90:545-54. 1999Mutations in several genes of Caenorhabditis elegans confer altered sensitivities to volatile anesthetics. A mutation in one gene, gas-1(fc21), causes animals to be immobilized at lower concentrations of all volatile anesthetics than in ..
- Allergic to anestheticsJonathan Moss
Anesthesiology 99:521-3. 2003
- SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODSDavid Allen; Fiscal Year: 2012..These included: [unreadable] The routine use of topical anesthetics, systemic analgesics, and humane endpoints to avoid and minimize pain and distress during in vivo ocular ..
- SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODSDavid Allen; Fiscal Year: 2011..These included: [unreadable] The routine use of topical anesthetics, systemic analgesics, and humane endpoints to avoid and minimize pain and distress during in vivo ocular ..
- SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODSDavid Allen; Fiscal Year: 2009..In addition, a comprehensive review of the use of topical anesthetics and systemic analgesics for reducing pain and distress will be conducted to determine their applicability in ..
- Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and StatinsTHOMAS JAY EBERT; Fiscal Year: 2013..A newer concept of "multi-organ" protection from I/R injury by volatile anesthetics might be explained by an effect of the volatile anesthetics on vascular endothelium...
- Microfluidic-microtiter interface for rapid large-scale screenings of C. elegansAdela Ben Yakar; Fiscal Year: 2010..the microfluidic immobilization chip has enabled rapid trapping of worms for surgery without using any anesthetics, reducing the time required to perform the surgery by a factor of 100 (from tens of minutes to several seconds) ..
- GABA chaperoning of epilepsy-associated GABAA receptor mutants.Nancy J Leidenheimer; Fiscal Year: 2012..2009) and is the target of several classes of therapeutic agents including benzodiazepines, barbiturates and anesthetics (Whiting, 2003)...
- Propofol and Protein Kinase C: Molecular Interactions in CardiomyocytesDEREK SCOTT DAMRON; Fiscal Year: 2011..The cellular and molecular mechanisms by which anesthetics preserve organ systems and promote cell survival from an ischemic challenge are not clearly established...
- Structural Rearrangements in GABA-A ReceptorsCYNTHIA M CZAJKOWSKI; Fiscal Year: 2012..and are modulated by a variety of clinically important drugs, such as benzodiazepines, barbiturates, steroids, anesthetics and anti-convulsants. Furthermore, GABAAR mutations have recently been linked to epilepsy...
- General Anesthetic Sites in GABA-A Receptor Subunit Interfacial PocketsStuart A Forman; Fiscal Year: 2013..acid type A (GABAA) receptors in the central nervous system are major targets of the potent general anesthetics etomidate, propofol, barbiturates, and neuroactive steroids...
- Neonatal Anesthetic NeurotoxicityPiyush M Patel; Fiscal Year: 2013DESCRIPTION (provided by applicant): A premise of general anesthesia is that anesthetics produce a non-toxic and reversible state of unconsciousness...
- Crosby_Gregory_Mechanisms of Post-Anesthetic CNS Dysfunction in AgingGregory Crosby; Fiscal Year: 2012..There has been little attention to these aspects of anesthetic action previously and elucidating how general anesthetics interfere acutely and persistently with morphological and functional indices of synaptic communication may ..
- The geriatric surgical patient: stress, anesthetics, and functional outcomesStacie Deiner; Fiscal Year: 2012..The results from this study will form the basis for larger comparative effectiveness trials of anesthetic technique and outcomes in the elderly. ..
- Role of Metallothioneins in Isoflurane-Preconditioning of neurons in vitro.Adam C Hall; Fiscal Year: 2010..preconditioning is a phenomenon whereby a prior exposure to clinical concentrations of commonly used inhaled anesthetics (including isoflurane) induces the production of endogenous protective proteins...
- Identification of altered lipids predictive of anesthetic-induced brain injuryXianlin Han; Fiscal Year: 2013..on the profoundly increasing preclinical evidences in rodents and nonhuman primates that the commonly used anesthetics in clinic are neurotoxic to the developing brain and may cause long-term neurobehavioral abnormalities...
- SYNAPTIC MECHANISMS OF GENERAL ANESTHETIC ACTIONHugh C Hemmings; Fiscal Year: 2013DESCRIPTION (provided by applicant): The pharmacology and toxicology of general anesthetics are remarkably incomplete for such a widely used and medically important class of drugs that are administered to increasingly older and sicker ..
- Perioperative Stroke and Cerebral Conditioning in the FemaleStephanie J Murphy; Fiscal Year: 2010..Our findings will elucidate the mechanisms by which female stroke outcomes are worsened by preischemic isoflurane exposure. ..
- Volatile Anesthetic Regulation of TASK Tandem Pore Potassium ChannelsJoseph F Cotten; Fiscal Year: 2012..Our SPECIFIC AIMS wil test the novel hypothesis that volatile anesthetics potentiate TASK-3 function indirectly by inhibition of basal or agonst-mediated Galpha-q protein coupled ..
- Arousal, orexins and anesthesiaMAX KELZ; Fiscal Year: 2010..They promise to unveil mechanisms of anesthetic-induced unconsciousness as well. Sensitivity to anesthetics varies across a population with some individuals requiring a higher dose to achieve a given depth of anesthesia...
- NEURONAL BASIS UNDERLYING VOLATILE ANESTHETIC INDUCED HYPNOSISMAX KELZ; Fiscal Year: 2013DESCRIPTION (provided by applicant): Although much progress has been made deciphering the effects of anesthetics upon individual ion channels, identification of the neural substrates upon which anesthetics act to produce their ..
- Cellular Mechanisms of Vasoregulation by Volatile AnestheticsRostislav Bychkov; Fiscal Year: 2012..provided by applicant): Two-pore-domain K+channels (K2P-channels) represent targets for actions of inhalation anesthetics on neurons...
- Adiponectin Polymorphisms, Insulin Resistance, and Pharmacokinetics in ObesityJerry Ingrande; Fiscal Year: 2013..A team of expert mentors has been compiled to ensure the candidate has ample support during this career development award period to meet the aims of this project and become an expert in pharmacogenomics. ..
- Structural Mechanism of the Acetylcholine Receptor in Tubular Membrane CrystalsPETER NIGEL UNWIN; Fiscal Year: 2013..Our structural studies are providing three-dimensional information about the binding sites for anesthetics and other drugs which affect the brain by modulating the function of these receptors...
- Role of the TRPV1 channel in myocardial salvage from ischemia-reperfusion injuryERIC RICHARD GROSS; Fiscal Year: 2012..I will then examine whether agents commonly given in the operating room, opioids and volatile anesthetics, require TRPV1 to reduce damage from ischemia-reperfusion injury (Aim 3)...
- Anesthetic Action: Molecular Substrates &Neural MechanismsDouglas A Bayliss; Fiscal Year: 2013..actions by using a forebrain-selective HCN1 knockout model;characterize effects of other dissociative anesthetics on HCN channels and anesthetic-induced hypnosis;identify molecular determinants for subunit-selective effects ..
- ANESTHETIC-INDUCED CARDIAC PRECONDITIONINGZeljko J Bosnjak; Fiscal Year: 2012..cardioprotection is the knowledge we have gained regarding the regulation of mitochondrial function by volatile anesthetics. Given the fundamental role of mitochondria in myocardial energetics and oxidative stress, we believe that they ..
- Local anesthetic receptor in peripheral Na+ channelsGING K WANG; Fiscal Year: 2013DESCRIPTION (provided by applicant): Local anesthetics (LAs) block voltage-gated Na+ channels and impede both motor and sensory functions reversibly during local anesthesia...
- Cognitive and socioemotional development after postnatal anesthesiaMark G Baxter; Fiscal Year: 2013DESCRIPTION (provided by applicant): General anesthetics may act as neurotoxins when given early in mammalian development...
- Genomics and pharmacodynamics of statin-related rhabdomyolysisBruce M Psaty; Fiscal Year: 2013..For some people, statins may be the equivalent of fluorinated- inhalation anesthetics, which precipitate malignant hyperthermia (MH) in susceptible individuals...
- Mechanisms of anesthesia mediaited neurotoxicityHuafeng Wei; Fiscal Year: 2012Increasing evidence suggests that commonly used inhaled anesthetics, especially isoflurane, cause neuronal apoptosis in the developing brain, which is associated with memory loss and learning disabilities...
- Mechanisms of Renal Protection with Volatile AnestheticsH Thomas Lee; Fiscal Year: 2013..We previously demonstrated that volatile anesthetics including isoflurane administered after renal ischemia protected against IR injury in part by the synthesis of ..
- Structure of the GABA-A Receptor Binding SitesCYNTHIA M CZAJKOWSKI; Fiscal Year: 2012..drugs, including muscle relaxants, sedative-hypnotics, anticonvulsants, anxiolytics, intravenous and volatile anesthetics, anti-emetics, drugs for nicotine addiction and drugs to treat Alzheimer[unreadable]s disease target these ..
- Structure of the GABA-A Receptor Binding SitesCYNTHIA M CZAJKOWSKI; Fiscal Year: 2013..drugs, including muscle relaxants, sedative-hypnotics, anti- convulsants, anxiolytics, intravenous and volatile anesthetics, anti-emetics, drugs for nicotine addiction and drugs to treat Alzheimer's disease target these channels...
- Cellular Cholesterol Movement and HomeostasisYvonne Lange; Fiscal Year: 2012..We suggest that a wide range of anesthetics act by intercalating into the plasma membrane bilayer of neurons, displacing and thereby activating a small ..
- The combined effects of zinc and ethanol at the glycine receptorLindsay M McCracken; Fiscal Year: 2011..protein targets of ethanol are glycine receptors, which in addition to being modulated by alcohol and anesthetics, are also modulated by endogenous zinc...
- Anesthetic Sites in Transmembrance Peptides by NMRPei Tang; Fiscal Year: 2012..the most crucial elements in the manifestation of neurotransmitter-gated receptors'sensitivity to general anesthetics. Modulation of protein global dynamics may underlie a common molecular mechanism of anesthetic action...
- Characterization of a novel presynaptic target for ethanol actionGREGG W ROMAN; Fiscal Year: 2012..In Caenorhabditis elegans, the homologous Unc13 protein is responsible for the sensitivity to volatile anesthetics. The C1 or diacylglycerol binding domain of the Munc13 family of proteins is structurally similar to that of ..
- Central mechanisms of maintenance of orofacial pain after injuryAsaf Keller; Fiscal Year: 2013..months, and the inflammation due to the surgical procedure can be separated with the use of long-duration local anesthetics. Our major hypothesis is that tissue and nerve injury in the orofacial region can lead to the maintenance of ..
- The role of ubiquitination in regulating GABA(A) receptor functional expressionStephen J Moss; Fiscal Year: 2010..the brain and are critical drug targets for therapeutic agents including benzodiazepines, barbiturates, general anesthetics and neurosteroids...
- Anesthesia-induced developmental neurodegenerationVESNA JEVTOVIC TODOROVIC JEVTOVIC-TODOROVIC; Fiscal Year: 2013..This is the main focus of our revised application. PUBLIC HEALTH RELEVANCE: Clinically used general anesthetics are damaging to developing mammalian brain...
- Selective targeting of sodium channel blockers to pain-sensing neuronsBruce P Bean; Fiscal Year: 2012..The most effective form of pain relief without loss of consciousness is provided by administration of local anesthetics, which act by inhibiting voltage-dependent sodium channels and thereby depressing electrical excitability...
- Integration of ascending and descending input to auditory cortexMatthew I Banks; Fiscal Year: 2013..cellular and circuit mechanisms of this integrative process in auditory cortex and its modulation by general anesthetics. Based on the laminar segregation of ascending and descending afferents to a column and of cell types with ..
- A Systems Neuroscience Approach for the Study of General AnesthesiaEmery N Brown; Fiscal Year: 2011..This research will also have broad impact on the training of anesthesiologists by placing greater emphasis on systems neuroscience. ..
- Structural biology of neurotransmitter ion channelsJames E Gouaux; Fiscal Year: 2013..Equally important, these ion channels are the targets of many therapeutic agents, from sedatives and anesthetics to anticonvulsants, and they are implicated or associated with a broad range of devastating diseases including ..
- The role of Drosophila CrebA in ethanol toleranceBENJAMIN R TROUTWINE; Fiscal Year: 2012..Drosophila acquire tolerance to the sedative effects of ethanol and organic solvent anesthetics such as benzyl alcohol after a single exposure...
- A Neural Systems Approach to Monitoring and Drug-Delivery for General AnesthesiaPATRICK PURDON; Fiscal Year: 2009..The proposed studies will result not only in dramatically improved anesthesia care in the long term, but will also result in fundamental discoveries and developments in systems neuroscience, neuroimaging, and drug delivery. ..
- Does Anesthetic Solubility Determine Receptor Specificity?ROBERT JOSEPH BROSNAN; Fiscal Year: 2013..Since each homologous pair of anesthetics will have a water solubility value on either side of the specificity "cut-off" value, we hypothesize that NMDA ..
- PROLONGED DURATION LOCAL ANESTHESIADaniel S Kohane; Fiscal Year: 2013..The purpose of this research is to develop particulate prolonged duration local anesthetics (PDLA) employing site 1 sodium channel blockers such as saxitoxin (STX)...
- Redesigning General AnesthesiaMatthew A Wilson; Fiscal Year: 2013..The paradigm-shifting question whose answer will revolutionize anesthesiology is not, "how do current anesthetics work?", but rather, "how should the state of general anesthesia be designed?" We hypothesize that the answer is ..
- Anesthetic actions on GABA(A) fast, slow, tonic and GABA(B) receptorsM Bruce MacIver; Fiscal Year: 2013..play for anesthetic- induced circuit depression, and 3 - to assess the role GABAB mediated inhibition plays for anesthetics. Information from these aims is essential for designing safer and more effective anesthetics that selectively ..
- The Impact Of Prolonged Anesthetic Exposure On Tau Pathology And FunctionRobert A Whittington; Fiscal Year: 2013..The etiology of AD is probably multifactorial;however, recent studies suggest that general anesthetics may contribute to the development and exacerbation of this neurodegenerative disorder...
- G Protein Modulation of Glycine Receptor Function and Ethanol ActionGregg E Homanics; Fiscal Year: 2012..and antagonist affinities and single channel conductance) were normal and receptor modulation by general anesthetics was not altered, indicating significant selectivity for EtOH...
- Neurophysiological Basis of General AnesthesiaALEXANDER PROEKT; Fiscal Year: 2013DESCRIPTION (provided by applicant): Advent of general anesthetics over a century ago revolutionized the practice of medicine by allowing humane care for surgical patients...
- Immunomodulatory mechanism of volatile anestheticsKoichi Yuki; Fiscal Year: 2013DESCRIPTION (provided by applicant): Volatile anesthetics are major drugs to provide general anesthesia during perioperative period...
- Neurodevelopment of Children Exposed to Anesthesia: A Population-Based AssessmentDavid O Warner; Fiscal Year: 2013..Existing studies show that exposure to multiple, but not single, anesthetics at a young age is associated with an increased frequency of learning disabilities, but there are significant ..
- VOLATILE ANESTHETICS AND NEURONAL CALCIUMTHOMAS JOSEPH JOHN BLANCK; Fiscal Year: 2010Immobility mediated by volatile anesthetics (VAs) appears to result largely from depression of excitatory neurotransmission at the spinal cord level...
- ANESTHETICS AND CARDIAC SIGNAL TRANSDUCTIONZeljko J Bosnjak; Fiscal Year: 2013..Specific Aim 3. Determine how anesthetics modulate human PT pore opening under I/R stress in intact human ventricular cardiomyocytes derived from N-iPSCs ..
- General Anesthetic Sites on Ligand-Gated Ion ChannelsKeith W Miller; Fiscal Year: 2013..General anesthetics act on a superfamily of ligand gated channels which include inhibitory anion channels gated by GABA and glycine,..
- Propofol in Exhaled Breath: Real-time Detection by Surface Acoustic Wave SensorsDONN MICHAEL DENNIS; Fiscal Year: 2012..carbon dioxide to assure placement of an endotracheal tube in the trachea and adequate ventilation, and anesthetics (e.g., desflurane, nitrous oxide) to maintain the appropriate "level of consciousness"/depth of anesthesia...
- Mechanism of neurological and cognitive side effects of sevoflurane anesthesia atAnatoly E Martynyuk; Fiscal Year: 2013..Based on our preliminary results and literature data we hypothesize: 1) anesthetics that enhance GABAA/glycine receptor activity may exacerbate GABA-induced depolarization and Ca2+ influx in ..
- Effects of general vs. regional anesthesia on infant neurodevelopment and apneaMary Ellen McCann; Fiscal Year: 2013..If general and regional awake anesthesia result in neurodevelopmental outcomes that are equivalent, this would support the safety of general anesthetics as currently used.
- Insecticide Action at the Local Anesthetic ReceptorDavid M Soderlund; Fiscal Year: 2011..g., local anesthetics, antiarrhythmics, anticonvulsants, neuroprotectants and analgesics) that bind to the "local anesthetic receptor"..
- THE EFFECT OF SEDATION ON PAIN PERCEPTIONMichael A Froelich; Fiscal Year: 2010..safe level of anesthesia while minimizing the cardiocirculatory, pulmonary, and cognitive effects of excessive anesthetics. We plan to investigate the clinical (psychometric) effect of drug-induced sedation on pain perception...
- INHALATIONAL ANESTHETICS AND CORONARY VASOMOTIONJOHN SILL; Fiscal Year: 1992Effects of the anesthetics isoflurane, halothane, enflurane, and nitrous oxide upon epicardial coronary dimensions and coronary arteriolar tone will be studied in dogs and humans...
- GENERAL ANESTHETICS AND CLONED VOLTAGE-GATED CHANNELSANA CORREA; Fiscal Year: 2000..Inhalation general anesthetics (GA), fundamental aides in surgical anesthesia, induce both but not without displaying some serious side ..
- AROMATIC AMINE LOCAL ANESTHETICS AND MEMBRANESIssaku Ueda; Fiscal Year: 1990..The fact that part of the aromatic amine local anesthetics exists as a positively charged form is consistent with receptor binding because biological membranes usually ..
- Anesthetics, GABA and the Injured BrainDavid Warner; Fiscal Year: 2006Perioperative stroke remains a major risk during surgery. Volatile anesthetics protect against experimental brain ischemia but the mechanism is not defined...
- ANESTHETIC TOXICITY--MECHANISMS AND PREVENTIONEvan Kharasch; Fiscal Year: 1999..Investigator's Abstract): The overall objective of this research proposal is to enhance the safety of volatile anesthetics by diminishing or preventing their toxicity...
- EFFECTS OF GENERAL ANESTHETICS ON NICOTINIC MEMBRANESLeonard Firestone; Fiscal Year: 1991The potency of most general anesthetics can be predicted by a shared physical feature, lipid solubility...
- The neurotransmitter release machinery: a new target general anestheticsBRUCE HERRING; Fiscal Year: 2009DESCRIPTION (provided by applicant): General anesthetics (GAs) are known to suppress central nervous system activity in part through the activation/facilitation of postsynaptic GABA(A) receptors...
- Volatile Anesthesic Inhibition of Ca2+ Release in AirwayGary Sieck; Fiscal Year: 2006Volatile anesthetics such as halothane, isoflurane and sevoflurane are potent bronchodilators. The long-term goal of the proposed research is to understand the mechanisms by which volatile anesthetics relax airway smooth muscle (ASM)...
- ANESTHETICS ALTER VASCULAR CELL PHOSPHATIDYLINOSITOLAudrey Robinson White; Fiscal Year: 1990..Our preliminary studies on the effects of anesthetics on smooth muscle cells show that the barbiturate, pentobarbital (Pb), dose-dependently inhibits PI hydrolysis ..
- Cerebal Ischemia During Anesthesia and SurgeryPiyush Patel; Fiscal Year: 2004..This has fostered an interest in identifying agents that might protect the brain against ischemic injury. Anesthetics are logical candidate neuroprotective agents because they reduce excitotoxic injury...
- INFLUENCE OF ANESTHETICS ON ISCHEMIC MYOCARDIUMDavid Warltier; Fiscal Year: 1990..In this proposal, the effects of 3 volatile anesthetics (halothane, enflurane and isoflurane) and 2 narcotic agonists (fentanyl and sufentanil) on ischemic myocardium ..
- GABAA RECEPTOR BETA-SUBUNIT AND GENERAL ANESTHETICSJay Yang; Fiscal Year: 2002..Recent progress suggests highly specific effects of several general anesthetics at the GABAA receptor; the details of this mechanism, however, are unknown...