central nervous system stimulants

Summary

Summary: A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.

Top Publications

  1. pmc European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD
    Sandra J J Kooij
    PsyQ, psycho medische programma s, Department Adult ADHD, Carel Reinierszkade 197, Den Haag, The Netherlands
    BMC Psychiatry 10:67. 2010
  2. pmc Methamphetamine toxicity and messengers of death
    Irina N Krasnova
    Molecular Neuropsychiatry Research Branch, Intramural Research Program, NIDA NIH DHHS, Baltimore, MD 21224, USA
    Brain Res Rev 60:379-407. 2009
  3. pmc The epidemiology of pharmacologically treated attention deficit hyperactivity disorder (ADHD) in children, adolescents and adults in UK primary care
    Suzanne McCarthy
    School of Pharmacy, University College Cork, Cork, Ireland
    BMC Pediatr 12:78. 2012
  4. ncbi The roles of dopamine and noradrenaline in the pathophysiology and treatment of attention-deficit/hyperactivity disorder
    Natalia Del Campo
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 69:e145-57. 2011
  5. ncbi ADHD drugs and serious cardiovascular events in children and young adults
    William O Cooper
    Division of General Pediatrics, Vanderbilt University, Nashville, TN 37232 4313, USA
    N Engl J Med 365:1896-904. 2011
  6. ncbi Lisdexamfetamine dimesylate: linear dose-proportionality, low intersubject and intrasubject variability, and safety in an open-label single-dose pharmacokinetic study in healthy adult volunteers
    James Ermer
    Shire Development, 725 Chesterbrook Blvd, Wayne, PA 19087, USA
    J Clin Pharmacol 50:1001-10. 2010
  7. ncbi Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin
    R B Rothman
    Clinical Psychopharmacology Section, Intramural Research Program, NIDA, NIH, Baltimore, Maryland 21224, USA
    Synapse 39:32-41. 2001
  8. ncbi Double-blind, placebo-controlled study of the efficacy and safety of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder
    Lenard A Adler
    Department of Psychiatry, New York University School of Medicine, 530 First Ave 7D, New York, NY 10016, USA
    J Clin Psychiatry 69:1364-73. 2008
  9. ncbi Pharmacokinetics of lisdexamfetamine dimesylate and its active metabolite, d-amphetamine, with increasing oral doses of lisdexamfetamine dimesylate in children with attention-deficit/hyperactivity disorder: a single-dose, randomized, open-label, crossover
    Samuel W Boellner
    Clinical Study Centers, Little Rock, Arkansas, USA
    Clin Ther 32:252-64. 2010
  10. ncbi Methylphenidate normalises activation and functional connectivity deficits in attention and motivation networks in medication-naïve children with ADHD during a rewarded continuous performance task
    Katya Rubia
    Department of Child Psychiatry, Institute of Psychiatry, King s College, London, UK
    Neuropharmacology 57:640-52. 2009

Detail Information

Publications330 found, 100 shown here

  1. pmc European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD
    Sandra J J Kooij
    PsyQ, psycho medische programma s, Department Adult ADHD, Carel Reinierszkade 197, Den Haag, The Netherlands
    BMC Psychiatry 10:67. 2010
    ..The evidence on persistence poses several difficulties for adult psychiatry considering the lack of expertise for diagnostic assessment, limited treatment options and patient facilities across Europe...
  2. pmc Methamphetamine toxicity and messengers of death
    Irina N Krasnova
    Molecular Neuropsychiatry Research Branch, Intramural Research Program, NIDA NIH DHHS, Baltimore, MD 21224, USA
    Brain Res Rev 60:379-407. 2009
    ....
  3. pmc The epidemiology of pharmacologically treated attention deficit hyperactivity disorder (ADHD) in children, adolescents and adults in UK primary care
    Suzanne McCarthy
    School of Pharmacy, University College Cork, Cork, Ireland
    BMC Pediatr 12:78. 2012
    ..The aim of this study was to investigate the annual prevalence and incidence of pharmacologically treated ADHD in children, adolescents and adults in UK primary care...
  4. ncbi The roles of dopamine and noradrenaline in the pathophysiology and treatment of attention-deficit/hyperactivity disorder
    Natalia Del Campo
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 69:e145-57. 2011
    ....
  5. ncbi ADHD drugs and serious cardiovascular events in children and young adults
    William O Cooper
    Division of General Pediatrics, Vanderbilt University, Nashville, TN 37232 4313, USA
    N Engl J Med 365:1896-904. 2011
    ..Adverse-event reports from North America have raised concern that the use of drugs for attention deficit-hyperactivity disorder (ADHD) increases the risk of serious cardiovascular events...
  6. ncbi Lisdexamfetamine dimesylate: linear dose-proportionality, low intersubject and intrasubject variability, and safety in an open-label single-dose pharmacokinetic study in healthy adult volunteers
    James Ermer
    Shire Development, 725 Chesterbrook Blvd, Wayne, PA 19087, USA
    J Clin Pharmacol 50:1001-10. 2010
    ..These findings indicate that the pharmacokinetic parameters of d-amphetamine were dose-proportional and predictable over a wide range of lisdexamfetamine dimesylate doses...
  7. ncbi Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin
    R B Rothman
    Clinical Psychopharmacology Section, Intramural Research Program, NIDA, NIH, Baltimore, Maryland 21224, USA
    Synapse 39:32-41. 2001
    ..the hypothesis that mesolimbic dopamine (DA) mediates, in animal models, the reinforcing effects of central nervous system stimulants such as cocaine and amphetamine...
  8. ncbi Double-blind, placebo-controlled study of the efficacy and safety of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder
    Lenard A Adler
    Department of Psychiatry, New York University School of Medicine, 530 First Ave 7D, New York, NY 10016, USA
    J Clin Psychiatry 69:1364-73. 2008
    ..To evaluate the efficacy and safety of 30, 50, and 70 mg/day lisdexamfetamine dimesylate compared with placebo in adults with attention-deficit/hyperactivity disorder (ADHD)...
  9. ncbi Pharmacokinetics of lisdexamfetamine dimesylate and its active metabolite, d-amphetamine, with increasing oral doses of lisdexamfetamine dimesylate in children with attention-deficit/hyperactivity disorder: a single-dose, randomized, open-label, crossover
    Samuel W Boellner
    Clinical Study Centers, Little Rock, Arkansas, USA
    Clin Ther 32:252-64. 2010
    ..Information on the pharmacokinetic profile of LDX in children with ADHD is lacking...
  10. ncbi Methylphenidate normalises activation and functional connectivity deficits in attention and motivation networks in medication-naïve children with ADHD during a rewarded continuous performance task
    Katya Rubia
    Department of Child Psychiatry, Institute of Psychiatry, King s College, London, UK
    Neuropharmacology 57:640-52. 2009
    ..We used functional magnetic resonance imaging (fMRI) to investigate the effects of MPH in medication-naïve children with ADHD on the activation and functional connectivity of "cool" attentional as well as "hot" motivation networks...
  11. ncbi Efficacy and tolerability of lisdexamfetamine dimesylate (NRP-104) in children with attention-deficit/hyperactivity disorder: a phase III, multicenter, randomized, double-blind, forced-dose, parallel-group study
    Joseph Biederman
    Department of Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Ther 29:450-63. 2007
    ..Following ingestion, the pharmacologically active d-amphetamine molecule is gradually released by rate-limited hydrolysis...
  12. ncbi Modafinil and methylphenidate for neuroenhancement in healthy individuals: A systematic review
    Dimitris Repantis
    Department of Psychiatry, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, 14050 Berlin, Germany
    Pharmacol Res 62:187-206. 2010
    ....
  13. ncbi Misuse and diversion of stimulants prescribed for ADHD: a systematic review of the literature
    Timothy E Wilens
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 47:21-31. 2008
    ..The purpose of this systematic review of the literature is to evaluate the extent and characteristics of stimulant misuse and diversion in attention-deficit/hyperactivity disorder (ADHD) and non-ADHD individuals...
  14. ncbi A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizes
    Stephen V Faraone
    Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    J Clin Psychiatry 71:754-63. 2010
    ....
  15. pmc Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens
    Michael Lazarus
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    J Neurosci 31:10067-75. 2011
    ..Our observations suggest that caffeine promotes arousal by activating pathways that traditionally have been associated with motivational and motor responses in the brain...
  16. pmc European guidelines on managing adverse effects of medication for ADHD
    J Graham
    Child and Adolescent Psychiatry, The Centre for Child Health, Dundee, UK
    Eur Child Adolesc Psychiatry 20:17-37. 2011
    ..Some of the effects examined appeared to be minimal in impact or difficult to distinguish from risk to untreated populations. However, several areas require further study to allow a more precise understanding of these risks...
  17. ncbi Long-acting medications for the hyperkinetic disorders. A systematic review and European treatment guideline
    Tobias Banaschewski
    Dept of Child and Adolescent Psychiatry Psychotherapy, University of Goettingen, Von Siebold Str 5, 37075 Goettingen, Germany
    Eur Child Adolesc Psychiatry 15:476-95. 2006
    ..Individual clinical choice is needed. (3) Both ATX and extended-release preparations of stimulants should be available. The choice will depend upon the circumstances, and detailed recommendations are made...
  18. ncbi Mechanisms of neurotransmitter release by amphetamines: a review
    David Sulzer
    Department of Psychiatry, Neurology and Pharmacology, New York State Psychiatric Institute, Columbia University, 650 W 168th Street, Black Building Room 309, New York, NY 10032, USA
    Prog Neurobiol 75:406-33. 2005
    ....
  19. ncbi Non-medical use of prescription stimulants among US college students: prevalence and correlates from a national survey
    Sean Esteban McCabe
    University of Michigan, Substance Abuse Research Center, Ann Arbor, MI 48105, USA
    Addiction 100:96-106. 2005
    ..To examine the prevalence rates and correlates of non-medical use of prescription stimulants (Ritalin, Dexedrine or Adderall) among US college students in terms of student and college characteristics...
  20. ncbi Lisdexamfetamine dimesylate and mixed amphetamine salts extended-release in children with ADHD: a double-blind, placebo-controlled, crossover analog classroom study
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 62:970-6. 2007
    ..Pharmacologically active d-amphetamine is released from lisdexamfetamine following oral ingestion...
  21. ncbi A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants
    R C Pierce
    Alcohol and Drug Abuse Program, Washington State University, Pullman 99164 6520, USA
    Brain Res Brain Res Rev 25:192-216. 1997
    ..This neural circuit is used as a template to organize the relevant biochemical and molecular findings into a model of the expression of behavioral sensitization...
  22. ncbi Evidence-based guidelines for management of attention-deficit/hyperactivity disorder in adolescents in transition to adult services and in adults: recommendations from the British Association for Psychopharmacology
    D J Nutt
    Psychopharmacology Unit, University of Bristol, Bristol, and Bethlem Royal Hospital, Kent, UK
    J Psychopharmacol 21:10-41. 2007
    ..We hope that, by the time these guidelines are updated, much evidence will be available to address the many directions for future research that are detailed here...
  23. ncbi 3-year follow-up of the NIMH MTA study
    Peter S Jensen
    Center for the Advancement of Children s Mental Health, Unit 78, Columbia University NYSPI, 1051 Riverside Drive, New York, NY 10027, USA
    J Am Acad Child Adolesc Psychiatry 46:989-1002. 2007
    ..This report examines 36-month outcomes, 2 years after treatment by the study ended...
  24. pmc Illicit use of specific prescription stimulants among college students: prevalence, motives, and routes of administration
    Christian J Teter
    School of Pharmacy, Northeastern University, Boston, Massachusetts, USA
    Pharmacotherapy 26:1501-10. 2006
    ..To explore the illicit use of specific prescription stimulants among college students and add to our understanding of reasons (motives) and routes of administration associated with illicit use of these drugs...
  25. ncbi Major physical and psychological harms of methamphetamine use
    Shane Darke
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia
    Drug Alcohol Rev 27:253-62. 2008
    ..The major physical and psychological health effects of methamphetamine use, and the factors associated with such harms...
  26. ncbi Pharmacokinetic variability of long-acting stimulants in the treatment of children and adults with attention-deficit hyperactivity disorder
    James C Ermer
    Clinical Pharmacology and Pharmacokinetics, Shire Development Inc, Wayne, Pennsylvania, USA
    CNS Drugs 24:1009-25. 2010
    ..As such, clinicians are urged both to adjust stimulant doses based on therapeutic response and the risk for adverse events and to monitor patients for potential causes of pharmacokinetic variability...
  27. ncbi Dopaminergic role in stimulant-induced wakefulness
    J P Wisor
    Sleep Disorders Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 21:1787-94. 2001
    ..Thus, dopamine transporters play an important role in sleep regulation and are necessary for the specific wake-promoting action of amphetamines and modafinil...
  28. pmc Are prescription stimulants "smart pills"? The epidemiology and cognitive neuroscience of prescription stimulant use by normal healthy individuals
    M Elizabeth Smith
    Department of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
    Psychol Bull 137:717-41. 2011
    ..In closing, we enumerate the many outstanding questions that remain to be addressed by future research and also identify obstacles facing this research...
  29. ncbi Mortality associated with attention-deficit hyperactivity disorder (ADHD) drug treatment: a retrospective cohort study of children, adolescents and young adults using the general practice research database
    Suzanne McCarthy
    Centre for Paediatric Pharmacy Research, The School of Pharmacy, University of London and the Institute of Child Health, University College London, London, UK
    Drug Saf 32:1089-96. 2009
    ....
  30. ncbi Attention deficit hyperactivity disorder in adults
    Michael Rösler
    Neurozentrum, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    World J Biol Psychiatry 11:684-98. 2010
    ..To examine available literature regarding attention deficit hyperactivity disorder (ADHD) in adults...
  31. ncbi Subjective, behavioral, and physiological effects of acute caffeine in light, nondependent caffeine users
    Emma Childs
    The University of Chicago, 5841 S Maryland Avenue, MC3077, Chicago, IL 60637, USA
    Psychopharmacology (Berl) 185:514-23. 2006
    ....
  32. ncbi Short-term cardiovascular effects of methylphenidate and adderall
    R L Findling
    Department of Psychiatry and Pediatrics, University Hospitals of Cleveland, Case Western Reserve University, OH 44106-5080, USA
    J Am Acad Child Adolesc Psychiatry 40:525-9. 2001
    ..In addition, under similar conditions, using similar methods, both medication treatments led to changes in blood pressure and pulse that were clinically insignificant...
  33. ncbi Modafinil for excessive sleepiness associated with shift-work sleep disorder
    Charles A Czeisler
    Division of Sleep Medicine, Harvard Medical School, and Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 353:476-86. 2005
    ..Patients with shift-work sleep disorder chronically have excessive sleepiness during night work and insomnia when attempting to sleep during the day. We evaluated the use of modafinil for treating sleepiness in patients with this disorder...
  34. pmc Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications
    Nora D Volkow
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    JAMA 301:1148-54. 2009
    ..Although initially launched as distinct from stimulants that increase extracellular dopamine by targeting dopamine transporters, recent preclinical studies suggest otherwise...
  35. ncbi Illicit use of prescription ADHD medications on a college campus: a multimethodological approach
    Alan D DeSantis
    The Department of Communication, The University of Kentucky, Lexington, KY 40506, USA
    J Am Coll Health 57:315-24. 2008
    ..The authors used quantitative and qualitative methodologies to investigate college students' perceptions and use of illegal Attention Deficit Hyperactivity Disorder (ADHD) stimulants during spring and summer 2006...
  36. ncbi Methamphetamine transiently increases the blood-brain barrier permeability in the hippocampus: role of tight junction proteins and matrix metalloproteinase-9
    Tânia Martins
    Laboratory of Pharmacology and Experimental Therapeutics, Faculty of Medicine, University of Coimbra, 3004 548 Coimbra, Portugal
    Brain Res 1411:28-40. 2011
    ..Overall, the present data demonstrate that METH transiently increases the BBB permeability in the hippocampus, which can be explained by alterations on TJ proteins and MMP-9...
  37. ncbi The impact of medications on quality of life in attention-deficit hyperactivity disorder: a systematic review
    David Coghill
    Centre for Neuroscience, Division of Medical Sciences, University of Dundee, Centre for Child Health, Dundee, UK
    CNS Drugs 24:843-66. 2010
    ..The lack of systematic studies of the impact on QOL of psychological therapies, either on their own or in multimodal combinations with medication, is a serious omission that should be urgently addressed...
  38. ncbi A dose-response study of OROS methylphenidate in children with attention-deficit/hyperactivity disorder
    Mark A Stein
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Pediatrics 112:e404. 2003
    ..This study was conducted to examine dosage effects on ADHD symptoms and stimulant side effects and to explore potential moderating effects of ADHD subtype...
  39. ncbi Review of medication adherence in children and adults with ADHD
    Lisa D Adler
    Cornell University, Ithaca, NY, USA
    Postgrad Med 122:184-91. 2010
    ..To review the literature on the prevalence, potential causes, and consequences of medication nonadherence in adult attention-deficit/hyperactivity disorder (ADHD)...
  40. pmc A disorder of anger and aggression: children's perspectives on attention deficit/hyperactivity disorder in the UK
    Ilina Singh
    London School of Economics and Political Science, BIOS Research Centre, London, UK
    Soc Sci Med 73:889-96. 2011
    ..The findings support a proposal for a complex sociological model of ADHD diagnosis and demonstrate the relevance of this model for national policy initiatives related to mental health and wellbeing in children...
  41. ncbi Why do children with ADHD discontinue their medication?
    Sara L Toomey
    Boston Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Pediatr (Phila) 51:763-9. 2012
    ..To examine factors associated with parent-reported discontinuation of attention-deficit/hyperactivity disorder (ADHD) medication...
  42. ncbi Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter
    S R Jones
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 18:1979-86. 1998
    ..Furthermore, these findings suggest that in the absence of pharmacological manipulation, such as the use of amphetamine, endogenous cytoplasmic DA normally does not reach sufficient concentrations to reverse the DAT...
  43. pmc Cardiovascular safety of central nervous system stimulants in children and adolescents: population based cohort study
    Almut G Winterstein
    Pharmaceutical Outcomes and Policy, College of Pharmacy, Epidemiology, Colleges of Medicine and Public Health and Health Professions, University of Florida, Gainesville, Florida 32611, USA
    BMJ 345:e4627. 2012
    To evaluate the cardiac safety of central nervous system stimulants in children and adolescents.
  44. ncbi Age-specific prevalence, incidence of new diagnoses, and drug treatment of attention-deficit/hyperactivity disorder in Germany
    Christina Lindemann
    Bremen Institute for Prevention Research and Social Medicine, Bremen, Germany
    J Child Adolesc Psychopharmacol 22:307-14. 2012
    ..The purpose of this study was to estimate the prevalence and incidence of new diagnoses of attention-deficit/hyperactivity disorder (ADHD) and assess drug treatment of ADHD in the 3-17 year age group in Germany...
  45. ncbi Striatal creatine and glutamate/glutamine in attention-deficit/hyperactivity disorder
    Normand J Carrey
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    J Child Adolesc Psychopharmacol 17:11-7. 2007
    ..We used short echo proton magnetic resonance spectroscopy (1H-MRS) to examine glutamate in the prefrontal cortex, left striatum, and, as a control area, the occipital lobe...
  46. ncbi "Adderall is definitely not a drug": justifications for the illegal use of ADHD stimulants
    Alan D DeSantis
    Department of Communication, University of Kentucky, Lexington, Kentucky, USA
    Subst Use Misuse 45:31-46. 2010
    ..We discuss limitations to the study and conclude by suggesting five strategies for prevention researchers that would directly target these four arguments...
  47. pmc Amphetamine toxicities: classical and emerging mechanisms
    Bryan K Yamamoto
    Department of Neurosciences, University of Toledo College of Medicine, Toledo, Ohio 43614, USA
    Ann N Y Acad Sci 1187:101-21. 2010
    ..Moreover, the high coincidence of substituted amphetamine abuse by humans with HIV and/or chronic stress exposure suggests a potential enhanced vulnerability of these individuals to the neurotoxic actions of the amphetamines...
  48. ncbi Illicit use of prescription stimulants among college students: prescription status, motives, theory of planned behaviour, knowledge and self-diagnostic tendencies
    Rachel Judson
    Department of Psychology, Bates College, Lewiston, Maine, USA
    Psychol Health Med 14:97-104. 2009
    ..Implications for future research and the need for interventions to provide aid to students who are at risk for using stimulant medications illicitly are discussed...
  49. ncbi The use of methylphenidate among students: the future of enhancement?
    Simon M Outram
    Novel Tech Ethics, Dalhousie University, 1234 LeMarchant Street, Halifax NS B3H 3P7, Canada
    J Med Ethics 36:198-202. 2010
    ..In light of these empirically based conclusions, the article discusses why methylphenidate might have become seen as a smart drug or cognitive enhancer...
  50. ncbi Abuse liability and safety of oral lisdexamfetamine dimesylate in individuals with a history of stimulant abuse
    D R Jasinski
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    J Psychopharmacol 23:419-27. 2009
    ..Abuse-related liking scores of LDX at a dose corresponding to a 50% higher amphetamine base (LDX 150 mg) were similar to d-amphetamine 40 mg...
  51. pmc Persistence of pharmacological treatment into adulthood, in UK primary care, for ADHD patients who started treatment in childhood or adolescence
    Suzanne McCarthy
    School of Pharmacy, University College Cork, Cork, Ireland
    BMC Psychiatry 12:219. 2012
    ....
  52. pmc An observational study of once-daily modified-release methylphenidate in ADHD: effectiveness on symptoms and impairment, and safety
    Manfred Dopfner
    Department of Child and Adolescent Psychiatry, University of Cologne, Cologne, Germany
    Eur Child Adolesc Psychiatry 20:S243-55. 2011
    ..Equasym XL(®) was generally well tolerated; only 3.16% of patients permanently discontinued treatment due to adverse events. Equasym XL(®) is effective and well tolerated in daily clinical practice...
  53. ncbi Caffeine improves supramaximal cycling but not the rate of anaerobic energy release
    Michael J Simmonds
    School of Physiotherapy and Exercise Science, Gold Coast Campus, Griffith University, Southport, QLD 4215, Australia
    Eur J Appl Physiol 109:287-95. 2010
    ..Considering caffeine ingestion did not change VO2 kinetics or isotime AO(2) deficit, increases in absolute AO(2) deficit may be a consequence of prolonged TE, rather than causal...
  54. pmc Withdrawal symptoms in abstinent methamphetamine-dependent subjects
    Todd Zorick
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Addiction 105:1809-18. 2010
    ..g. depression, psychosis) persist beyond a month of abstinence...
  55. pmc Chronic methamphetamine exposure suppresses the striatal expression of members of multiple families of immediate early genes (IEGs) in the rat: normalization by an acute methamphetamine injection
    Michael T McCoy
    Molecular Neuropsychiatry Research Branch, DHHS NIH NIDA Intramural Research Program, NIDA NIH, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 215:353-65. 2011
    ..Repeated injections of cocaine cause blunted responses to acute cocaine challenge-induced increases in the expression of immediate early genes (IEGs)...
  56. ncbi Methylphenidate and risk of serious cardiovascular events in adults
    Hedi Schelleman
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
    Am J Psychiatry 169:178-85. 2012
    ..The authors sought to determine whether use of methylphenidate in adults is associated with elevated rates of serious cardiovascular events compared with rates in nonusers...
  57. ncbi ADHD in children, adolescents, and adults
    Sreenivas Katragadda
    Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03766, USA
    Prim Care 34:317-41; abstract viii. 2007
    ..The primary care physician should be able to screen, diagnose, educate, and initiate medication management in patients with uncomplicated ADHD...
  58. ncbi Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese methamphetamine abusers
    Norikazu Ezaki
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Ann N Y Acad Sci 1139:49-56. 2008
    ..Thus, we suggest a possible role for the 5-HTTLPR polymorphism in MAP psychosis...
  59. ncbi Pharmacological treatment patterns among patients with attention-deficit/hyperactivity disorder: retrospective claims-based analysis of a managed care population
    Laura Christensen
    i3 Innovus, Ann Arbor, MI, USA
    Curr Med Res Opin 26:977-89. 2010
    ....
  60. pmc Cardiovascular events and death in children exposed and unexposed to ADHD agents
    Hedi Schelleman
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104 6021, USA
    Pediatrics 127:1102-10. 2011
    ..The objective of this study was to compare the rate of severe cardiovascular events and death in children who use attention-deficit/hyperactivity disorder (ADHD) medications versus nonusers...
  61. pmc Functional improvement and correlations with symptomatic improvement in adults with attention deficit hyperactivity disorder receiving long-acting methylphenidate
    J K Buitelaar
    Department of Cognitive Neuroscience, University Medical Centre, St Radboud and Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, The Netherlands
    Psychol Med 42:195-204. 2012
    ..Daily functioning was assessed as part of an open-label extension, and associations with symptom scores were evaluated...
  62. pmc The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors
    Kyle C Schmitt
    Department of Pharmacology, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 6:e25790. 2011
    ..Our findings highlight a mechanistic difference between modafinil and cocaine-like stimulants and further demonstrate that the conformational effects of a given DAT inhibitor influence its phenomenological effects...
  63. ncbi A controlled trial of extended-release guanfacine and psychostimulants for attention-deficit/hyperactivity disorder
    Timothy E Wilens
    Massachusetts General Hospital, Boston, MA, USA
    J Am Acad Child Adolesc Psychiatry 51:74-85.e2. 2012
    ....
  64. pmc The need for speed: an update on methamphetamine addiction
    Alasdair M Barr
    Centre for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    J Psychiatry Neurosci 31:301-13. 2006
    ..It is hoped that increased knowledge of MA abuse will provide the basis for future treatment strategies...
  65. ncbi Methylphenidate improves working memory and set-shifting in AD/HD: relationships to baseline memory capacity
    Mitul A Mehta
    University of Cambridge, Department of Psychiatry, UK
    J Child Psychol Psychiatry 45:293-305. 2004
    ..Clear delineation of the effects of methylphenidate upon such cognitive functions in AD/HD would enhance understanding of the effects of drug treatment...
  66. ncbi Sex differences in attentional performance and their modulation by methylphenidate in children with attention-deficit/hyperactivity disorder
    Thomas Gunther
    Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, University Hospital of the RWTH Aachen, Aachen, Germany
    J Child Adolesc Psychopharmacol 20:179-86. 2010
    ....
  67. pmc A comparison of amphetamine- and methamphetamine-induced locomotor activity in rats: evidence for qualitative differences in behavior
    Darien A Hall
    Department of Psychology and Neuroscience Program, University of Illinois at Urbana Champaign, 731 Psychology Bldg MC 716, 603 E Daniel St, Champaign, IL 61820, USA
    Psychopharmacology (Berl) 195:469-78. 2008
    ....
  68. ncbi The rise of methamphetamine in Southeast and East Asia
    Rebecca McKetin
    National Drug and Alcohol Research Centre, University of New South Wales, Australia
    Drug Alcohol Rev 27:220-8. 2008
    ..Southeast and East Asia has become a global hub for methamphetamine production and trafficking over the past decade. This paper describes the rise of methamphetamine supply and to what extent use of the drug is occurring in the region...
  69. ncbi Translational approaches to frontostriatal dysfunction in attention-deficit/hyperactivity disorder using a computerized neuropsychological battery
    Samuel R Chamberlain
    Department of Psychiatry and Medical Research Council Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 69:1192-203. 2011
    ..The findings suggest overlapping but also distinct early cognitive effects of ADHD medications and have important implications for understanding the pathophysiology of ADHD and for future trials...
  70. pmc National trends in child and adolescent psychotropic polypharmacy in office-based practice, 1996-2007
    Jonathan S Comer
    College of Physicians and Surgeons, Columbia University, and the New York State Psychiatric Institute, New York, USA
    J Am Acad Child Adolesc Psychiatry 49:1001-10. 2010
    ..To examine patterns and recent trends in multiclass psychotropic treatment among youth visits to office-based physicians in the United States...
  71. ncbi Methylphenidate improves deficient error evaluation in children with ADHD: an event-related brain potential study
    Lisa M Jonkman
    Faculty of Psychology, Department of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands
    Biol Psychol 76:217-29. 2007
    ..Methylphenidate's ameliorating effects might be established through its influence on brain networks including posterior (parietal) cortex, enabling children with ADHD to allocate more attention to significant events...
  72. pmc Methamphetamine causes microglial activation in the brains of human abusers
    Yoshimoto Sekine
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 28:5756-61. 2008
    ..These results suggest that chronic self-administration of methamphetamine can cause reactive microgliosis in the brains of human methamphetamine abusers, a level of activation that appears to subside over longer periods of abstinence...
  73. pmc Effects of clonidine and methylphenidate on family quality of life in attention-deficit/hyperactivity disorder
    Michael Cannon
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    J Child Adolesc Psychopharmacol 19:511-7. 2009
    ..The aim of this study was to determine the effect on family quality of life (QOL) of clonidine (CLON) and methylphenidate (MPH), used alone and in combination, in treating attention-deficit/hyperactivity disorder (ADHD)...
  74. ncbi Efficacy of a novel biphasic controlled-release methylphenidate formula in adults with attention-deficit/hyperactivity disorder: results of a double-blind, placebo-controlled crossover study
    Umesh Jain
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Clin Psychiatry 68:268-77. 2007
    ..To evaluate the efficacy and safety of a new biphasic multilayer-release (MLR) methylphenidate formulation in a double-blind, placebo-controlled crossover study of adults with attention-deficit/hyperactivity disorder (ADHD)...
  75. pmc Understanding the effects of stimulant medications on cognition in individuals with attention-deficit hyperactivity disorder: a decade of progress
    James Swanson
    Department of Pediatrics, University of California, Irvine, CA, USA
    Neuropsychopharmacology 36:207-26. 2011
    ..We will review some key findings from the recent literature, and then offer interpretations of the progress that has been made over the past decade in understanding the cognitive effects of stimulant medication on individuals with ADHD...
  76. ncbi Nonmedical use of prescription stimulants in the United States
    Larry A Kroutil
    RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA
    Drug Alcohol Depend 84:135-43. 2006
    ..This study estimated prevalences and correlates of stimulant diversion in the United States and examined relationships between diversion and measures of abuse or dependence...
  77. ncbi Long-term safety and effectiveness of lisdexamfetamine dimesylate in adults with attention-deficit/ hyperactivity disorder
    Richard Weisler
    Department of Psychiatry, University of North Carolina, Chapel Hill, USA
    CNS Spectr 14:573-85. 2009
    ..To evaluate the long-term safety and effectiveness of lisdexamfetamine dimesylate (LDX) in the treatment of adults with attention-deficit/hyperactivity disorder (ADHD)...
  78. pmc Medical use, illicit use, and diversion of abusable prescription drugs
    Sean Esteban McCabe
    Substance Abuse Research Center, University of Michigan, Ann Arbor 48105 2194, USA
    J Am Coll Health 54:269-78. 2006
    ..The authors provide evidence that prescription drug abuse is a problem among college students...
  79. ncbi The changing face of teenage drug abuse--the trend toward prescription drugs
    Richard A Friedman
    Psychopharmacology Clinic at Weill Cornell Medical College, New York, USA
    N Engl J Med 354:1448-50. 2006
  80. ncbi Neurochemical enhancement of conscious error awareness
    Robert Hester
    Department of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia
    J Neurosci 32:2619-27. 2012
    ....
  81. ncbi Pharmacokinetics of methylphenidate after oral administration of two modified-release formulations in healthy adults
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425 0742, USA
    Clin Pharmacokinet 42:393-401. 2003
    ..To compare the rate and extent of absorption of DL-threo-methylphenidate (MPH) from two modified-release MPH formulations at their respective recommended starting doses in healthy adult volunteers...
  82. ncbi The neuropharmacology of ADHD drugs in vivo: insights on efficacy and safety
    D J Heal
    RenaSci Consultancy Ltd, BioCity, Nottingham NG1 1GF, UK
    Neuropharmacology 57:608-18. 2009
    ..This review will discuss the in vivo pharmacological profiles of approved catecholaminergic drugs for treatment of ADHD and implications for their clinical efficacy and abuse liability...
  83. ncbi Caffeine and anaerobic performance: ergogenic value and mechanisms of action
    J K Davis
    Department of Health and Human Performance, Texas A and M University Commerce, Commerce, Texas, USA
    Sports Med 39:813-32. 2009
    ..The exact mechanisms behind caffeine's action remain to be elucidated...
  84. pmc Selective effects of methylphenidate in attention deficit hyperactivity disorder: a functional magnetic resonance study
    C J Vaidya
    Department of Psychology, Stanford University, Stanford, CA 94305
    Proc Natl Acad Sci U S A 95:14494-9. 1998
    ..These results suggest that ADHD is characterized by atypical frontal-striatal function and that methylphenidate affects striatal activation differently in ADHD than in healthy children...
  85. pmc Pattern classification of working memory networks reveals differential effects of methylphenidate, atomoxetine, and placebo in healthy volunteers
    Andre F Marquand
    Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, London, UK
    Neuropsychopharmacology 36:1237-47. 2011
    ..Thus, interactions between drug effects and motivational state are crucial in defining the effects of MPH and ATX...
  86. pmc Advances in understanding and treating ADHD
    Kevin M Antshel
    State University of New York, Upstate Medical University, Department of Psychiatry and Behavioral Sciences, 750 East Adams Street, Syracuse, NY 13210, USA
    BMC Med 9:72. 2011
    ....
  87. pmc Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons
    Yan Rao
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 117:4022-33. 2007
    ..These results indicate that synaptic plasticity due to prolonged wakefulness occurs in circuits responsible for arousal and may contribute to changes in the brain and body of animals experiencing sleep loss...
  88. ncbi Incidence of Parkinson's disease among hospital patients with methamphetamine-use disorders
    Russell C Callaghan
    Social, Epidemiological Research Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Mov Disord 25:2333-9. 2010
    ..We strongly emphasize the preliminary nature of the findings. Nevertheless, these data, requiring replication, provide some evidence that methamphetamine users might be at greater than normal risk for developing Parkinson's disease...
  89. pmc Psychostimulant treatment and the developing cortex in attention deficit hyperactivity disorder
    Philip Shaw
    Child Psychiatry Branch, Bldg 10, Center Dr, NIMH, Bethesda, MD 20892, USA
    Am J Psychiatry 166:58-63. 2009
    ..The authors sought to determine prospectively whether psychostimulant treatment for attention deficit hyperactivity disorder (ADHD) was associated with differences in the development of the cerebral cortex during adolescence...
  90. ncbi Comparing the efficacy of stimulants for ADHD in children and adolescents using meta-analysis
    Stephen V Faraone
    Departments of Psychiatry and Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA
    Eur Child Adolesc Psychiatry 19:353-64. 2010
    ..This difference in effect size may be due to differences between amfetamine and methylphenidate in the molecular mechanisms involved in facilitating the dopaminergic neurotransmission...
  91. ncbi [ADHD in adulthood--guidelines based on expert consensus with DGPPN support]
    D Ebert
    Nervenarzt 74:939-46. 2003
  92. ncbi Molecular bases of methamphetamine-induced neurodegeneration
    Jean Lud Cadet
    Molecular Neuropsychiatry Branch, NIDA Intramural Research Program, NIH DHHS, Baltimore, Maryland 21224, USA
    Int Rev Neurobiol 88:101-19. 2009
    ..Better understanding of the cellular and molecular mechanisms involved in METH toxicity should help to generate modern therapeutic approaches to prevent or attenuate the long-term consequences of psychostimulant use disorders in humans...
  93. ncbi Human immunodeficiency virus type 1 Tat and methamphetamine affect the release and activation of matrix-degrading proteinases
    Katherine Conant
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA
    J Neurovirol 10:21-8. 2004
    ..These results also suggest a potential mechanism for acceleration of HIVD with methamphetamine use...
  94. pmc Clinically relevant doses of methylphenidate significantly occupy norepinephrine transporters in humans in vivo
    Jonas Hannestad
    Department of Psychiatry, Yale PET Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 68:854-60. 2010
    ..The goal of this study was to use positron emission tomography to measure the occupancy of brain norepinephrine transporter by methylphenidate in vivo in humans...
  95. ncbi Health outcomes associated with methamphetamine use among young people: a systematic review
    Brandon D L Marshall
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, BC, Canada
    Addiction 105:991-1002. 2010
    ..While responses have focused upon various perceived severe harms of MA use, effective public health interventions require a strong scientific evidence base...
  96. pmc Impulsiveness as a timing disturbance: neurocognitive abnormalities in attention-deficit hyperactivity disorder during temporal processes and normalization with methylphenidate
    Katya Rubia
    Department of Child Psychiatry MRC Center for Social, Genetic and Developmental Psychiatry SGDP, Institute of Psychiatry, 16 De Crespigny Park, London, UK
    Philos Trans R Soc Lond B Biol Sci 364:1919-31. 2009
    ....
  97. ncbi Effects of methylphenidate on the catecholaminergic system in attention-deficit/hyperactivity disorder
    Timothy E Wilens
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychopharmacol 28:S46-53. 2008
    ..Overall, the changes in catecholaminergic tone clinically manifest as improvements in attention deficit, distractibility, and motor hyperactivity in patients with ADHD...
  98. ncbi Involvement of pallidotegmental neurons in methamphetamine- and MK-801-induced impairment of prepulse inhibition of the acoustic startle reflex in mice: reversal by GABAB receptor agonist baclofen
    Sawako Arai
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    Neuropsychopharmacology 33:3164-75. 2008
    ..GABA(B) receptor may constitute a putative target in treating neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia and METH psychosis...
  99. pmc Safety and effectiveness of coadministration of guanfacine extended release and psychostimulants in children and adolescents with attention-deficit/hyperactivity disorder
    Thomas J Spencer
    Clinical and Research Program, Pediatric Psychopharmacology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
    J Child Adolesc Psychopharmacol 19:501-10. 2009
    ....
  100. ncbi What are the cognitive effects of stimulant medications? Emphasis on adults with attention-deficit/hyperactivity disorder (ADHD)
    Claire Advokat
    Department of Psychology, Louisiana State University, 215 Audubon Hall, Baton Rouge, LA 70803, USA
    Neurosci Biobehav Rev 34:1256-66. 2010
    ..Stimulants may influence cognition by their effects on physiological arousal. Regardless, the evidence does not support the conclusion that stimulants are cognitive 'enhancers.'..
  101. ncbi Caffeine potentiates low frequency skeletal muscle force in habitual and nonhabitual caffeine consumers
    M Tarnopolsky
    Department of Neurology and Rehabilitation Medicine and Kinesiology, McMaster University Medical Center, Hamilton, Ontario L8N 3Z5, Canada
    J Appl Physiol (1985) 89:1719-24. 2000
    ..These data support the hypothesis that some of the ergogenic effect of caffeine in endurance exercise performance occurs directly at the skeletal muscle level...

Research Grants74

  1. Inhibition of Carboxylesterase Metabolism by Ethanol
    Robert B Parker; Fiscal Year: 2011
    ..used medications including angiotensin-converting enzyme inhibitors, anticancer agents, statins, central nervous system stimulants, and drugs of abuse such as cocaine and heroin...
  2. Comparative Safety and Effectiveness of Stimulants in Medicaid Youth with ADHD
    Almut G Winterstein; Fiscal Year: 2010
    DESCRIPTION (provided by the PI): Comparative effectiveness data that quantify effects of central nervous system stimulants (stimulants) on real-life function in the treatment of attention deficit/hyperactivity (ADHD) disorder are ..
  3. AN ECOGENETIC STUDY OF ADHD
    Stephen Faraone; Fiscal Year: 2003
    ..Furthermore, no studies have used an ecogenetic approach to sharpen the accuracy of risk prediction. ..
  4. 2/5-The Psychiatric GWAS Consortium: Integrated & Coordinated GWAS Meta-Analyses
    Stephen Faraone; Fiscal Year: 2008
    ..Finally, the PGC proposes to abide as fully as possible with the NIH's GWAS data sharing policies and we provide a detailed data sharing plan and timetable. [unreadable] [unreadable] [unreadable]..
  5. Validating Novel Familial Phenotypes of Drug Abuse
    Stephen Faraone; Fiscal Year: 2007
    ..State of the art statistical techniques will be employed. ..
  6. PREVENTION OF CIGARETTE SMOKING IN ADHD YOUTH
    Joseph Biederman; Fiscal Year: 2001
    ..Since there are estimated to be 3.5 million children with ADHD and 20% have been shown to be smokers, targeting this group could potentially impact 700,000 children and adolescents. ..
  7. Adult Outcome of Attention Deficit Hyperactivity Disorder
    Joseph Biederman; Fiscal Year: 2007
    ..For these reasons, we expect the proposed work to clarify the course and outcome of ADHD. ..
  8. Course of psychopathology in female youth: Analysis with extant longitudinal data
    Joseph Biederman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. Analysis of an ADHD Whole Genome Association Scan
    Stephen Faraone; Fiscal Year: 2007
    ..All genotype data generated by the GAIN whole genome association scan will be made available to the scientific community by GAIN as soon as the genotypes are completed. [unreadable] [unreadable] [unreadable]..
  10. Searching for ADHD Susceptibility Genes
    Stephen V Faraone; Fiscal Year: 2010
    ..That, in turn, should facilitate the search for newer, more effective treatments for the disorder. ..
  11. Juvenile Bipolar Disorder and Substance Abuse
    Timothy E Wilens; Fiscal Year: 2010
    ..Since BPD is identifiable and treatable, findings from the four-year follow-up will provide valuable information to formulate prevention and early intervention strategies. ..
  12. LONG TERM DRUG ABUSE IN ADHD
    Timothy Wilens; Fiscal Year: 2002
    ..abstract_text> ..
  13. Collaborative Pediatric Bipolar Disorder Conference
    Joseph Biederman; Fiscal Year: 2007
    ..While the proposed conference does not intend to solve all outstanding problems associated with pediatric bipolar disorder, it will provide a forum to begin formulating a solution. ..
  14. Evaluation of Stimulant Drugs
    Sharon Wigal; Fiscal Year: 2006
    ..Within-subject PK variability in time-course of serum concentration for each medication will be analyzed, and the time-response characteristics also will be estimated based on PD measures for methylphenidate. ..
  15. LONGITUDINAL FOLLOW UP OF ADHD GIRLS AND THEIR SIBLINGS
    Joseph Biederman; Fiscal Year: 2002
    ....
  16. TESTING THE VALIDITY OF ADULT ATTENTION DEFICIT DISORDER
    Stephen Faraone; Fiscal Year: 2002
    ..Thus, if founded, we expect that the proposed work will lead to a program of research that can both clarify the nosological complexities of adult ADHD and clarify the nature of genes that are risk factors for the disorder. ..
  17. Substance Abuse in ADHD Girls
    Timothy Wilens; Fiscal Year: 2006
    ..Thus, the research, approach, and goals of this R01 application are consistent with those underscored in the PA and by the Institute of Medicine as being of the highest research priority. ..
  18. International Multi-Center ADHD Genetics Project
    Stephen Faraone; Fiscal Year: 2007
    ..abstract_text> ..
  19. PEDIATRIC BIPOLAR COLLABORATIVE MOOD STABILZER TRAIL
    Robert Findling; Fiscal Year: 2003
    ..Lastly, this trial will provide descriptive information on the stability of acute phase response to monotherapy over a 16 week continuation phase. ..
  20. Nonmedical Prescription Drug Use among College Students
    SEAN MCCABE; Fiscal Year: 2005
    ..Findings from this research will have important implications for the understanding of the epidemiology, prevention and treatment of prescription drug abuse. ..
  21. Epidemiology of Prescription Drug Abuse in the United States
    SEAN MCCABE; Fiscal Year: 2007
    ..It will help identify risk factors for substance abuse. Most importantly, the findings will provide guidance for the prevention, assessment, and treatment of prescription drug abuse. [unreadable] [unreadable]..
  22. Progestrone and the Effects of Nicotine
    Mehmet Sofuoglu; Fiscal Year: 2006
    ..By characterizing the progesterone effects on nicotine dependence, this study may provide a better understanding of the mechanisms which mediate the sex and menstrual cycle phase effects on nicotine dependence. ..
  23. Methylphenidate Abuse Potential in ADHD Adults
    Scott Kollins; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  24. Prescription Drug Abuse Among College Students
    SEAN MCCABE; Fiscal Year: 2005
    ....
  25. Protective Influence of Residential Learning Communities
    SEAN MCCABE; Fiscal Year: 2006
    ..At each measurement point, participants will complete a set of measures that assess substance use behaviors and constructs addressed by RLCs. ..
  26. Smoking reinforcement in adults with and without ADHD
    Scott H Kollins; Fiscal Year: 2010
    ..This project will help identify some of the reasons why people with ADHD smoke more and will potentially lead to better prevention and treatment programs. ..
  27. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2010
    ..This proposal, by testing the efficacy of carvedilol and investigating the influence of withdrawal severity on carvedilol's efficacy, may result in development of more effective treatments for cocaine addiction. ..
  28. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2009
    ..The findings of this study will provide valuable information to develop new pharmacotherapies for smoking cessation. ..
  29. Sexual Orientation, Substance Use and Mental Health
    SEAN MCCABE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  30. Follow up of the PATS sample
    Scott Kollins; Fiscal Year: 2008
    ..Aim 4 is to determine the stability of the ADHD diagnosis and other comorbidities made for study entry at age 3-5 years across subsequent development [unreadable] [unreadable]..
  31. Mechanisms of Nicotine Dependence in ADHD Adults
    Scott Kollins; Fiscal Year: 2008
    ..Data generated will also lead to subsequent clinical projects to develop more effective interventions for nicotine dependence in this high risk group. [unreadable] [unreadable] [unreadable]..
  32. UCI-CFC Projects on School Readiness
    James Swanson; Fiscal Year: 2002
    ....
  33. Genetics of Attention Deficit-Hyperactivity Disorder
    James Swanson; Fiscal Year: 2006
    ..Genomic haplotypes", meaning haplo-specific genotypes at more than one locus, will be defined and tested for possible interactive roles among the genes. ..
  34. Role of hypocretin/histamine in Narcolepsy/EDS disorders
    Seiji Nishino; Fiscal Year: 2009
    ..We believe that results from these studies will bring new insights regarding the roles of the hypocretin/histamine interaction in narcolepsy and other EDS disorders and better treatment modalities in humans. ..
  35. Role of Histamine in Narcolepsy/EDS Disorders
    Seiji Nishino; Fiscal Year: 2008
    ..As almost nothing is known on the pathophysiology of non- hypocretin deficient hypersomnias, we believe this work to be ideally suited for a small grant application. [unreadable] [unreadable] [unreadable]..
  36. " Evaluating a Microeconomic Intervention for High Risk Women in India"
    SUSAN GAIL SHERMAN; Fiscal Year: 2010
    ..Ultimately, the evaluation will provide the cost effectiveness of such an intervention as well as the impact on HIV/STI incidence and risky behaviors. ..
  37. Modafinil Treatment for Fatigue in HIV+ Patients
    Judith Rabkin; Fiscal Year: 2008
    ..The major aims concern modafinil efficacy for fatigue compared to placebo, safety in terms of effects on immunologic/virologic measures, and impact on depressive symptoms when present at baseline. ..
  38. RUPP-PI
    Oscar Bukstein; Fiscal Year: 2006
    ..The expertise and experience at this RUPP-PI site also will be directed to train new investigators. In creating TASA, a collaborative group of 8 applicants forged the ability to work together. ..
  39. DAYTIME SLEEPINESS--PREVALENCE, CONSEQUENCES, AND RISKS
    Thomas Roth; Fiscal Year: 2003
    ..The important contribution of the present proposal is that it will be the first population-based study to use laboratory assessments, its consequences and risks to measure sleepiness. ..
  40. DHEA EFFECTS ON MOOD IN DEPRESSED HIV+ PATIENTS
    Judith Rabkin; Fiscal Year: 2003
    ..This will permit the investigators to assess potential underlying mechanisms for the putative therapeutic effects of DHEA on mood, libido, and body composition. ..
  41. PHARMACOLOGICAL STUDIES OF HUMAN AND CANINE NARCOLEPSY
    Seiji Nishino; Fiscal Year: 2002
    ....
  42. Home Base Treatment for Drug Use in Early Adolescents
    Oscar Bukstein; Fiscal Year: 2005
    ..These interventions are expected to improve not only substance abuse outcomes, but a range of impairments and symptoms associated with the DBDs and high risk for the early onset type of substance use disorder. ..
  43. DYING AT HOME OF AIDS & CANCER: PREFERENCES & OUTCOMES
    Judith Rabkin; Fiscal Year: 2004
    ..The data collected in the preliminary study will be used in the full-scale study. ..
  44. HIV BEHAVIORS IN INJECTING AND NONINJECTING DRUG USERS
    Susan Sherman; Fiscal Year: 2003
    ..Additionally, we are complementing our research with the inclusion of NIUs of whom we will compare and contrast with our new injectors and, observe factors associated with the transition into an injecting career. ..
  45. Medication Management Decisions in Schizophrenia
    Mark Olfson; Fiscal Year: 2003
    ..The results will inform quality improvement programs by identifying key modifiable determinants of the quality of medication management in the community treatment of schizophrenia. ..
  46. Therapeutic Placebos as Complementary Therapy in ADHD
    Adrian Sandler; Fiscal Year: 2004
    ....
  47. METHYLPHENIDATE TREATMENT OF ADHD IN CHILDREN WITH TS
    Kenneth Gadow; Fiscal Year: 2004
    ..To evaluate the impact of tic severity and comorbid internalizing and externalizing symptoms on clinical outcome, children with ADHD/+tics will be compared with an additional sample of children with ADHD/-tics at ages 11 and 16 years. ..
  48. Can beta-lactam antibiotics decrease morphine physical dependence?
    SCOTT RAWLS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  49. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE-LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 2009
    ..The number of prenatally MA exposed children continues to grow. Our goal is to develop models of early MA exposure that permit an understanding of the long-term consequences on brain development and cognition. ..
  50. PROMOTING EVIDENCE-BASED ADHD TREATMENT IN THE COMMUNITY
    JEFF EPSTEIN; Fiscal Year: 2003
    ..The study design will allow for between-groups and within-group comparisons of pediatricians' utilization of the infrastructure, pediatricians' practice behaviors, child outcomes, consumer satisfaction, and costs. ..
  51. Effects of Neonatal MDMA on Brain and Behavior
    Charles V Vorhees; Fiscal Year: 2010
    ....
  52. Neuropharmacology of Tramadol: Clinical Efficacy and Abuse Potential
    WILLIAM WALTON STOOPS; Fiscal Year: 2010
    ..Developing analgesics with reduced abuse potential may reduce the prevalence of prescription opioid misuse and subsequent opioid use disorders. ..
  53. CONTROLLED STUDY OF METHYLPHENIDATE IN ADULTS WITH ADHD
    Thomas Spencer; Fiscal Year: 2002
    ..The auditory and visual continuous performance tasks and the Stroop test will be used to further assess treatment efficacy. A larger neuropsychological battery will be used to assess the long term effects of MPH treatment. ..
  54. DEVELOPMENTAL EFFECTS OF METHLENEDIOXYMETHAMPHETAMINE
    Charles Vorhees; Fiscal Year: 2002
    ..Such data will help identify risks associated with the prenatal use of MDMA on brain and cognitive development. ..
  55. Enhancing School-Based Services for ADHD Students
    DESIREE MURRAY; Fiscal Year: 2003
    ..abstract_text> ..
  56. Functional neuroanatomical deficits in ADHD families
    Scott Kollins; Fiscal Year: 2004
    ..Imaging will be performed at corresponding imaging sites at DUMC, Weill Medical College of Cornell University, and Stanford University respectively. ..
  57. Anatomy and Activation of Nucleus Accumbens CART Neurons
    GEORGE HUBERT; Fiscal Year: 2008
    ..This will add to our understanding of the anatomy of drug abuse and to hypothesize treatments to alleviate this major social problem. ..
  58. Dopamine Transporter Binding by PET in Adult ADHD
    Thomas Spencer; Fiscal Year: 2007
    ..qenetic risk factors, a) We hypothesize that DAT binding will be associated with the 480 allele of the 40-bp VNTR in the 3'-untranslated region of the dopamine transporter gene. ..
  59. Cannabinoid Regulation of Basal Ganglia Glutamate and GABA
    SCOTT RAWLS; Fiscal Year: 2007
    ..Our outcomes will be a first step in determining whether blocking endocannabinoid inactivation offers any therapeutic advantage over direct activation of cannabinoid receptors with marijuana. [unreadable] [unreadable] [unreadable]..
  60. AMPHETAMINE-LIKE STIMULANTS: NOREPINEPHRINE & BEHAVIOR
    CRAIG BERRIDGE; Fiscal Year: 2005
    ..Information obtained in these studies may provide insight into mechanisms subserving, and treatment of, stimulant drug abuse. ..
  61. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  62. Neurobiology of Orexin/Hypocretin-Induced Arousal
    CRAIG BERRIDGE; Fiscal Year: 2004
    ..These studies will provide a better understanding of the neurobiology of orexin, the neurobiology of sleep and waking, and the potential role of orexin in narcolepsy and other disorders of arousal. ..
  63. Tobacco Quitlines: An Adjunct to Dental Interventions
    Judith Gordon; Fiscal Year: 2006
    ..In addition, we will conduct an economic analysis to determine the relative cost effectiveness of each intervention. ..
  64. Microarray analysis of morphine's behavioral effects
    GREGORY ELMER; Fiscal Year: 2007
    ..abstract_text> ..
  65. Help Seeking by At-Risk Youth After Suicide Screenings
    Madelyn Gould; Fiscal Year: 2005
    ..abstract_text> ..
  66. MONITORING METHAMPHETAMINE ABUSE TREATMENT WITH 1H MRS
    Linda Chang; Fiscal Year: 2001
    ..This comprehensive approach will allow us to determine the relationship between changes in cognitive function and metabolite changes in brain tissue associated with chronic methamphetamine abuse and treatment. ..
  67. Serotonin, Drug Use and MDMA Induced Deficits
    FREDERICK MOELLER; Fiscal Year: 2005
    ..Specific Aim 3: To determine whether neurobehavioral deficits seen in heavy MDMA users are related to serotonergic function as measured by a mCPP neuroendocrine challenge in these subjects. ..
  68. MECHANISM OF ACTION OF DRUGS OF ABUSE--AMPHETAMINE
    Ronald Kuczenski; Fiscal Year: 2004
    ..The possibility of nonsynaptic release sites on nigrostriatal DA afferents will be assessed by labeling components of the release mechanism and then correlating them with the locations of dopamine receptors. ..
  69. Algorithm for drug discovery
    GREGORY ELMER; Fiscal Year: 2007
    ..Second, it will establish a core database for data mining and provide a template for use in screening novel compounds with potential clinical efficacy. [unreadable] [unreadable] [unreadable]..
  70. Neuroanatomical MRI Studies of Childhood Disorders
    Bradley Peterson; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  71. Parental Influences on Peer Socialization Among Children with ADHD
    AMORI MIKAMI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  72. FMRI STUDIES OF IMPULSE CONTROL IN CHILDHOOD DISORDERS
    Bradley Peterson; Fiscal Year: 2002
    ..These studies should provide important new insights into the underlying neurobiological basis of each disorder. ..