nitric oxide donors

Summary

Summary: A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81)

Top Publications

  1. ncbi Nitric oxide donors release extracellular traps from human neutrophils by augmenting free radical generation
    Satyananda Patel
    Cardiovascular Pharmacology Unit, Central Drug Research Institute Council of Scientific and Industrial Research, Lucknow, India
    Nitric Oxide 22:226-34. 2010
  2. ncbi Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2
    Sangwon F Kim
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Science 310:1966-70. 2005
  3. ncbi Nitric oxide donor-induced persistent inhibition of cell adhesion protein expression and NFkappaB activation in endothelial cells
    Thomas Waldow
    Herzzentrum Dresden GmbH, Universitatsklinikum Carl Gustav Carus, 01307 Dresden, Germany
    Nitric Oxide 15:103-13. 2006
  4. pmc Nitric oxide regulates lung carcinoma cell anoikis through inhibition of ubiquitin-proteasomal degradation of caveolin-1
    Pithi Chanvorachote
    Department of Physiology, Chulalongkorn University, Bangkok 10330, Thailand
    J Biol Chem 284:28476-84. 2009
  5. ncbi MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: implications in breast cancer
    Shehla Pervin
    Department of Obstetrics and Gynecology and Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1740, USA
    Cancer Res 63:8853-60. 2003
  6. pmc Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress
    Jianjun Gao
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794 5200, USA
    Proc Natl Acad Sci U S A 102:17207-12. 2005
  7. ncbi Syntheses, calcium channel agonist-antagonist modulation activities, and nitric oxide release studies of nitrooxyalkyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2,1,3-benzoxadiazol-4-yl)pyridine-5-carboxylate racemates, enantiomers, and diastereomers
    Rudong Shan
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, T6G 2N8 Canada
    J Med Chem 47:254-61. 2004
  8. ncbi The effect of nitric oxide donors on nitric oxide synthase-expressing myenteric neurones in culture
    M Zandecki
    Centre for Gastroenterological Research, Katholieke Universiteit Leuven, Belgium
    Neurogastroenterol Motil 18:307-15. 2006
  9. ncbi A self-propelling cycle mediated by reactive oxide species and nitric oxide exists in LPS-activated microglia
    Zhang Lijia
    Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, People s Republic of China
    Neurochem Int 61:1220-30. 2012
  10. ncbi Phase II study of nitric oxide donor for men with increasing prostate-specific antigen level after surgery or radiotherapy for prostate cancer
    D Robert Siemens
    Department of Urology and Centre for Applied Urological Research, Queen s University, Kingston, Ontario, Canada
    Urology 74:878-83. 2009

Research Grants

  1. ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGY
    Paul Kaufman; Fiscal Year: 2009
  2. PKG Redox Modulation of Cardiac Function and Disease
    DAVID ALAN KASS; Fiscal Year: 2013
  3. NITRIC OXIDE AND GASTROINTESTINAL OXIDATIVE INJURY
    Walee Chamulitrat; Fiscal Year: 1999
  4. Novel therapy for female sexual dysfunction
    Garry Southan; Fiscal Year: 2001
  5. Abnormalities in Keratoconus Corneas
    MARIA KENNEY; Fiscal Year: 2003
  6. Flow-Mediated Dilation of Human Coronary Arterioles
    David D Gutterman; Fiscal Year: 2010
  7. RETINAL VASCULAR DYSFUNCTION FOLLOWING ISCHEMIA
    JEFFREY GIDDAY; Fiscal Year: 2000
  8. NITRIC OXIDE IN NORMAL AND DISEASED OCULAR MUSCLE
    HENRY KAMINSKI; Fiscal Year: 2000
  9. REACTIVE OXYGEN SPECIES AND HEMOGLOBIN-INDUCED INJURY
    ANN BALDWIN; Fiscal Year: 2003
  10. Preventing Resuscitation Injury and Improving Outcomes
    Richard Kerber; Fiscal Year: 2005

Detail Information

Publications345 found, 100 shown here

  1. ncbi Nitric oxide donors release extracellular traps from human neutrophils by augmenting free radical generation
    Satyananda Patel
    Cardiovascular Pharmacology Unit, Central Drug Research Institute Council of Scientific and Industrial Research, Lucknow, India
    Nitric Oxide 22:226-34. 2010
    ..We thus demonstrate that NO by augmenting free radical formation in human neutrophils mediates NETs release...
  2. ncbi Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2
    Sangwon F Kim
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Science 310:1966-70. 2005
    ..Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction between two inflammatory systems may inform the development of anti-inflammatory drugs...
  3. ncbi Nitric oxide donor-induced persistent inhibition of cell adhesion protein expression and NFkappaB activation in endothelial cells
    Thomas Waldow
    Herzzentrum Dresden GmbH, Universitatsklinikum Carl Gustav Carus, 01307 Dresden, Germany
    Nitric Oxide 15:103-13. 2006
    ..In summary, a short preincubation of HUVEC with SNAP/Cys results in a persistent suppression of NFkappaB-dependent expression of CAM. The stabilization of IkappaBalpha over the same time span may be causally related to this effect...
  4. pmc Nitric oxide regulates lung carcinoma cell anoikis through inhibition of ubiquitin-proteasomal degradation of caveolin-1
    Pithi Chanvorachote
    Department of Physiology, Chulalongkorn University, Bangkok 10330, Thailand
    J Biol Chem 284:28476-84. 2009
    ..These findings indicate a novel pathway for NO regulation of Cav-1, which could be a key mechanism of anoikis resistance in tumor cells...
  5. ncbi MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: implications in breast cancer
    Shehla Pervin
    Department of Obstetrics and Gynecology and Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1740, USA
    Cancer Res 63:8853-60. 2003
    ..Our results indicate that expression of MKP-1 by NO leading to dephosphorylation of ERK1/2 is the initial essential event that commits the cells to the apoptotic pathway in breast cancer cells...
  6. pmc Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress
    Jianjun Gao
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794 5200, USA
    Proc Natl Acad Sci U S A 102:17207-12. 2005
    ....
  7. ncbi Syntheses, calcium channel agonist-antagonist modulation activities, and nitric oxide release studies of nitrooxyalkyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2,1,3-benzoxadiazol-4-yl)pyridine-5-carboxylate racemates, enantiomers, and diastereomers
    Rudong Shan
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, T6G 2N8 Canada
    J Med Chem 47:254-61. 2004
    ....
  8. ncbi The effect of nitric oxide donors on nitric oxide synthase-expressing myenteric neurones in culture
    M Zandecki
    Centre for Gastroenterological Research, Katholieke Universiteit Leuven, Belgium
    Neurogastroenterol Motil 18:307-15. 2006
    ..In conclusion, the NO donor SNP decreases the number of NOS-expressing myenteric neurones time and concentration dependently, without affecting the amount of neuronal material. Glutathione plays an important protective role...
  9. ncbi A self-propelling cycle mediated by reactive oxide species and nitric oxide exists in LPS-activated microglia
    Zhang Lijia
    Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, People s Republic of China
    Neurochem Int 61:1220-30. 2012
    ..It may be responsible partially for the ongoing microglial activation and the progressive nature of neurodegenerative diseases...
  10. ncbi Phase II study of nitric oxide donor for men with increasing prostate-specific antigen level after surgery or radiotherapy for prostate cancer
    D Robert Siemens
    Department of Urology and Centre for Applied Urological Research, Queen s University, Kingston, Ontario, Canada
    Urology 74:878-83. 2009
    ..Preclinical, proof-of-principle studies have demonstrated that nitric oxide signaling plays a significant role in the hypoxia-induced progression of prostate cancer...
  11. ncbi Nitric oxide is an essential negative regulator of cell proliferation in Xenopus brain
    N Peunova
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 21:8809-18. 2001
    ..NOS inhibition yielded larger brains with grossly perturbed organization. Our results indicate that NO is an essential negative regulator of neuronal precursor proliferation during vertebrate brain development...
  12. ncbi Nitric oxide donor and non steroidal anti inflammatory drugs as a therapy for muscular dystrophies: evidence from a safety study with pilot efficacy measures in adult dystrophic patients
    Maria Grazia D'Angelo
    E Medea Scientific Institute, Bosisio Parini, Italy
    Pharmacol Res 65:472-9. 2012
    ..Systemic administration of ibuprofen and isosorbide dinitrate provides an adequate safety margin for clinical studies aimed at assessing efficacy...
  13. ncbi Nitric oxide donors inhibit the coxsackievirus B3 proteinases 2A and 3C in vitro, virus production in cells, and signs of myocarditis in virus-infected mice
    Roland Zell
    Institute for Virology, Medical Center at the Friedrich Schiller University, Winzerlaer Strasse 10, 07745 Jena, Germany
    Med Microbiol Immunol 193:91-100. 2004
    ....
  14. ncbi S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function
    Kenny K K Chung
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 304:1328-31. 2004
    ..The inhibition of parkin's ubiquitin E3 ligase activity by S-nitrosylation could contribute to the degenerative process in these disorders by impairing the ubiquitination of parkin substrates...
  15. ncbi Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling
    Kenji Kasuno
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan 563 0053
    J Biol Chem 279:2550-8. 2004
    ..We conclude that the NO donor NOC18 induces HIF-1alpha synthesis under conditions of NO formation during normoxia and that hydroxylation of HIF-1alpha is not regulated by NOC18...
  16. ncbi ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status
    Song Ja Kim
    National Research Laboratory, Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500 712, Korea
    J Biol Chem 277:1332-9. 2002
    ..Our findings collectively suggest that ERK-1/2 and p38 kinase oppositely regulate NO-induced apoptosis of chondrocytes, in association with p53 accumulation, caspase-3 activation, and differentiation status...
  17. pmc Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide
    Douglas D Thomas
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:8894-9. 2004
    ..The findings show that concentration and duration of NO exposure are critical determinants in the regulation of tumor-related proteins...
  18. ncbi Nitric oxide suppresses NADPH oxidase-dependent superoxide production by S-nitrosylation in human endothelial cells
    Stavros Selemidis
    Bernard O Brien Institute of Microsurgery, University of Melbourne, Fitzroy, Victoria 3065, Australia
    Cardiovasc Res 75:349-58. 2007
    ..Here we investigate the regulation of NADPH oxidase activity by nitric oxide (NO)...
  19. pmc Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro
    Brian J Lee
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Brain Res 1307:22-7. 2010
    ..Edaravone significantly ameliorated this response. These data suggest that free radical scavengers are effective in all cell types of the neurovascular unit, and should still be considered as a potential therapeutic approach for stroke...
  20. ncbi Protein S-nitrosylation: a physiological signal for neuronal nitric oxide
    S R Jaffrey
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Cell Biol 3:193-7. 2001
    ..Targets of NO include metabolic, structural and signalling proteins that may be effectors for neuronally generated NO. These findings establish protein S-nitrosylation as a physiological signalling mechanism for nNOS...
  21. pmc Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation
    Niki L Reynaert
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 101:8945-50. 2004
    ..Collectively, our findings demonstrate that IKKbeta is an important target for the redox regulation of NF-kappaB by endogenous or exogenous NO, providing an additional mechanism for its antiinflammatory properties...
  22. pmc Role of nitric oxide signaling components in differentiation of embryonic stem cells into myocardial cells
    Kalpana Mujoo
    Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center, 1825 Pressler Street, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:18924-9. 2008
    ..These studies demonstrate that cGMP-mediated NO signaling plays an important role in the differentiation of ES cells into myocardial cells...
  23. pmc Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): potential role of cyclin D1
    S Pervin
    Department of Obstetrics and Gynecology and Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 98:3583-8. 2001
    ..We conclude that down-regulation of cyclin D1 protein by DETA-NONOate played an important role in the cytostasis and arrest of these tumor cells in the G(1) phase of the cell cycle...
  24. ncbi Nitric oxide-induced down-regulation of beta-catenin in colon cancer cells by a proteasome-independent specific pathway
    Laurent Prevotat
    Laboratoire d immunologie et immunothérapie des cancers, EPHE INSERM U517, IFR100, Faculty of Medicine, 7 bd Jeanne d Arc, 21079 Dijon, France
    Gastroenterology 131:1142-52. 2006
    ..Because an inappropriate activation of beta-catenin has been associated with intestinal cell malignant transformation, we explored whether nitric oxide could affect beta-catenin expression and function...
  25. ncbi ZJM-289, a novel nitric oxide donor, alleviates the cerebral ischaemic-reperfusion injury in rats
    Pei Zhuang
    Department of Pharmacology, China Pharmaceutical University, Nanjing, China
    Clin Exp Pharmacol Physiol 37:e121-7. 2010
    ..Therefore, a suitable NO donor might be an effective candidate for the treatment of acute stroke by neuroprotection...
  26. ncbi The mechanism of action of nitric oxide-donating aspirin
    Khosrow Kashfi
    Department of Physiology and Pharmacology, City University of New York Medical School, New York, NY 10031, USA
    Biochem Biophys Res Commun 358:1096-101. 2007
    ..We propose a mechanism of action of NO-ASA involving formation of quinone methide from its para and ortho isomers and of a carbocation from the meta, with the NO-releasing group functioning as a leaving group...
  27. ncbi Nitric oxide-mediated cytoprotection of hepatocytes from glucose deprivation-induced cytotoxicity: involvement of heme oxygenase-1
    Byung Min Choi
    Medicinal Resources Research Center MRRC and the Department of Microbiology and Immunology, Wonkwang University School of Medicine, Iksan, Chonbuk, South Korea
    Hepatology 37:810-23. 2003
    ..Thus, HO-1 might be an important cellular target of NO donor with clinical implications for the prevention of acute liver injury in several pathological conditions...
  28. ncbi Tyrosine nitration on p65: a novel mechanism to rapidly inactivate nuclear factor-kappaB
    Sung Wook Park
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Cell Proteomics 4:300-9. 2005
    ..This study identified a novel and efficient pathway where NO rapidly inactivated NF-kappaB activity by inducing Tyr nitration on p65...
  29. ncbi Tumor necrosis factor alpha but not interleukin 1 beta mediates neuroprotection in response to acute nitric oxide excitotoxicity
    Nicolas P Turrin
    Laboratory of Molecular Endocrinology, Centre Hospitalier de l Universite Laval Research Center, Sainte Foy, Quebec, G1V 4G2, Canada
    J Neurosci 26:143-51. 2006
    ..These findings may have direct implications for the use anti-inflammatory drugs in acute neurodegenerative and demyelinating disorders...
  30. pmc Vascular smooth muscle relaxation mediated by nitric oxide donors: a comparison with acetylcholine, nitric oxide and nitroxyl ion
    J C Wanstall
    School of Biomedical Sciences, Department of Physiology and Pharmacology, The University of Queensland, Brisbane, Queensland, Australia
    Br J Pharmacol 134:463-72. 2001
    ..Spermine NONOate, which generates NO spontaneously outside the tissue, was the drug that most closely resembled (but was not identical to) exogenous NO...
  31. ncbi Role of nitric oxide, reactive oxygen species, and p38 MAP kinase in the regulation of human chondrocyte apoptosis
    Klaus Kuhn
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Cell Physiol 197:379-87. 2003
    ..The pro-apoptotic effect of IL-1beta is not dependent on NO. In contrast, the anti-apoptotic effect of IL-1beta observed in a minority of samples is partially NO-dependent...
  32. ncbi Exogenous nitric oxide upregulates p21(waf1/cip1) in pulmonary microvascular smooth muscle cells
    William H Stotz
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Vasc Res 41:211-9. 2004
    ..The ability of NO to induce p21 upregulation may be a mechanism by which it exerts antiproliferative effects in PMVSMC...
  33. ncbi The role of nitric oxide donors in treating cerebral vasospasm after subarachnoid hemorrhage
    Ali R Fathi
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bldg 10, Room 3D20, SNB NINDS NIH, Bethesda, MD, USA
    Acta Neurochir Suppl 110:93-7. 2011
    ..Additional novel concepts to increase NO concentrations, such as the activation of endothelial nitric oxide synthase (eNOS), are discussed...
  34. ncbi Even after UVA-exposure will nitric oxide protect cells from reactive oxygen intermediate-mediated apoptosis and necrosis
    C V Suschek
    Research Group Immunobiology, , , Germany
    Cell Death Differ 8:515-27. 2001
    ..Thus, the experiments presented demonstrate that NO exposure during or even after a ROS-mediated toxic insult fully protects from apoptosis or necrosis by maintaining membrane integrity and function...
  35. ncbi Evidence for involvement of c-Src in the anti-apoptotic action of nitric oxide in serum-deprived RINm5F cells
    J R Tejedo
    Laboratory of Biochemistry of the Immune System, Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, University of Sevilla, Avenida Sanchez Pizjuan, 41009, Seville, Spain
    Cell Signal 13:809-17. 2001
    ..We thus propose that activation of c-Src is an early step in the chain of events that signal cGMP-dependent anti-apoptotic actions of NO in mitocohondria...
  36. ncbi Inhibition of cathepsin K by nitric oxide donors: evidence for the formation of mixed disulfides and a sulfenic acid
    M D Percival
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
    Biochemistry 38:13574-83. 1999
    ..This work also shows that oxidative thiol modifications besides S-nitrosylation should be considered when the effects of NO and NO donors on critical thiol-containing proteins are investigated...
  37. ncbi RS-alpha-lipoic acid protects cholinergic cells against sodium nitroprusside and amyloid-beta neurotoxicity through restoration of acetyl-CoA level
    Hanna Bielarczyk
    Department of Laboratory Medicine, Medical University of Gdansk, Gdansk, Poland
    J Neurochem 98:1242-51. 2006
    ..Thus, we conclude that, in cholinergic neurons, particular elements of the pyruvate-acetyl-CoA-acetylcholine pathway form a functional unit responding uniformly to nerotoxic and neuroprotectory conditions...
  38. pmc Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways
    David S Gelinas
    Department of Pharmacology, University of Montreal, Montreal QC, Canada
    Br J Pharmacol 137:1021-30. 2002
    ..5. In conclusion, VEGF induces an immediate cGMP synthesis through the PLC-Ca2+/CaM pathway, and that the induction of delayed cGMP synthesis implies Akt and PKC activity...
  39. ncbi Nitric oxide donors: chemical activities and biological applications
    Peng George Wang
    Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA
    Chem Rev 102:1091-134. 2002
  40. ncbi GSNO attenuates EAE disease by S-nitrosylation-mediated modulation of endothelial-monocyte interactions
    Ratna Prasad
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Glia 55:65-77. 2007
    ..These observations suggest that GSNO exerts its protective effects in EAE by inhibition of cellular infiltration into the CNS by S-nitrosylation of p65, thereby modulating NF-kappaB-CAMs pathway in endothelial cells...
  41. ncbi The attenuation of hemorrhage-induced liver injury by exogenous nitric oxide, L-arginine, and inhibition of inducible nitric oxide synthase
    Roberto Anaya-Prado
    Borgess Research Institute, Trauma, Surgery Research Sciences and Molecular Biology, Kalamazoo, Michigan 49048, USA
    J Invest Surg 16:247-61. 2003
    ..The protective action noted with L-arginine cannot be fully explained within the context of this article, although it could be most likely associated with the supplementation of eNOS-generated NO...
  42. ncbi Nitric oxide stimulates PC12 cell proliferation via cGMP and inhibits at higher concentrations mainly via energy depletion
    Anna Bal-Price
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, UK
    Nitric Oxide 14:238-46. 2006
    ..Our results indicate that NO at low concentrations increases cell proliferation via cGMP, while high concentrations of NO block proliferation via inhibition of both glycolysis and respiration, causing energy depletion...
  43. pmc Nitric oxide release combined with nonsteroidal antiinflammatory activity prevents muscular dystrophy pathology and enhances stem cell therapy
    Silvia Brunelli
    Department of Experimental Medicine, University of Milano Bicocca, 20052 Monza, Italy
    Proc Natl Acad Sci U S A 104:264-9. 2007
    ....
  44. ncbi Nitric oxide and the regulation of gene expression
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Wasserturmstrasse 3, D 91054, Erlangen, Germany
    Trends Cell Biol 11:66-75. 2001
    ....
  45. ncbi Ex vivo treatment with nitric oxide increases mesoangioblast therapeutic efficacy in muscular dystrophy
    Clara Sciorati
    Stem Cell Research Institute, H San Raffaele Scientific Institute, 20132, Milan, Italy
    J Cell Sci 119:5114-23. 2006
    ..We conclude that NO donors exert multiple beneficial effects on mesoangioblasts that may be used to increase their efficacy in cell therapy of muscular dystrophies...
  46. ncbi Deciphering the protective role of nitric oxide against salt stress at the physiological and proteomic levels in maize
    Xuegui Bai
    Key Laboratory of Biodiversity and Biogeography, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, China
    J Proteome Res 10:4349-64. 2011
    ..During this process, G-protein signaling is an early event that works upstream of NO biogenesis...
  47. pmc Co-administration of ibuprofen and nitric oxide is an effective experimental therapy for muscular dystrophy, with immediate applicability to humans
    Clara Sciorati
    San Raffaele Scientific Institute, Stem Cell Research Institute, Milan, Italy
    Br J Pharmacol 160:1550-60. 2010
    ....
  48. pmc Pulmonary nanoparticle exposure disrupts systemic microvascular nitric oxide signaling
    Timothy R Nurkiewicz
    Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    Toxicol Sci 110:191-203. 2009
    ..These results indicate that in conjunction with microvascular dysfunction, nanoparticle exposure also decreases NO bioavailability through at least two functionally distinct mechanisms that may mutually increase local reactive species...
  49. ncbi Nitric oxide acts as a volume transmitter to modulate electrical properties of spontaneously firing neurons via apamin-sensitive potassium channels
    Liana Artinian
    Department of Biology, Georgia State University, Atlanta, Georgia 30302 4010, USA
    J Neurosci 30:1699-711. 2010
    ....
  50. ncbi Effect of nitric oxide donors on NADPH oxidase signaling pathway in human neutrophils in vitro
    Magdalena Klink
    Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    Immunobiology 214:692-702. 2009
    ..We show that whereas NO donors have no effect on MAPKs activity, they do decrease PMA- and/or fMLP-induced phosphorylation of p47(phox) and PKC as well as PMA- and fMLP-induced ROS production...
  51. pmc Response to reactive nitrogen intermediates in Mycobacterium tuberculosis: induction of the 16-kilodalton alpha-crystallin homolog by exposure to nitric oxide donors
    T R Garbe
    Department of Microbiology and Immunology, University of Texas Health Science Center San Antonio 78284, USA
    Infect Immun 67:460-5. 1999
    ..tuberculosis protein induced upon exposure to reactive nitrogen intermediates...
  52. ncbi Iron released by sodium nitroprusside contributes to heme oxygenase-1 induction via the cAMP-protein kinase A-mitogen-activated protein kinase pathway in RAW 264.7 cells
    Hye Jung Kim
    Department of Pharmacology, College of Medicine, Gyeongsang National University, 92 Chilam dong, Jinju, South Korea
    Mol Pharmacol 69:1633-40. 2006
    ..Therefore, studies on the effects of SNP should consider the role of iron in some biological functions. We concluded that iron released by SNP contributes to HO-1 induction via the cAMP-PKA-mitogen-activated protein kinase pathway...
  53. ncbi Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha
    Thilo Hagen
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Science 302:1975-8. 2003
    ..Thus, the signaling consequences of hypoxia may be profoundly modified by nitric oxide...
  54. ncbi Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide
    H Kimura
    Investigative Treatment Division, National Cancer Center Research Institute East, Kashiwa, Chiba, Japan
    Blood 95:189-97. 2000
    ..These results show that there is a primary role for NO in the control of VEGF synthesis and in cell adaptations to hypoxia. (Blood. 2000;95:189-197)..
  55. pmc S-nitrosylation of endothelial nitric oxide synthase is associated with monomerization and decreased enzyme activity
    Kandasam Ravi
    Department of Pediatrics, Northwestern University, Chicago, IL 60611 3008, USA
    Proc Natl Acad Sci U S A 101:2619-24. 2004
    ..Therefore, this study links the inhibitory action of NO with the destruction of zinc tetrathiolate cluster at the dimeric interface through S-nitrosylation of the cysteine residues...
  56. ncbi Nitric oxide inhibits caspase-3 by S-nitrosation in vivo
    L Rossig
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Biol Chem 274:6823-6. 1999
    ..Thus, NO supplied by exogenous NO donors serves in vivo as an antiapoptotic regulator of caspase activity via S-nitrosation of the Cys-163 residue of caspase-3...
  57. ncbi Nitric oxide decreases subventricular zone stem cell proliferation by inhibition of epidermal growth factor receptor and phosphoinositide-3-kinase/Akt pathway
    Ana Torroglosa
    Area de Fisiologia, Facultad de Medicina, Universidad de Cadiz, Plaza Falla 9, 11003 Cadiz, Spain
    Stem Cells 25:88-97. 2007
    ....
  58. pmc Pharmacology and potential therapeutic applications of nitric oxide-releasing non-steroidal anti-inflammatory and related nitric oxide-donating drugs
    J E Keeble
    Centre for Cardiovascular Biology and Medicine, King s College, University of London, Guy s Campus, London SE1 9RT
    Br J Pharmacol 137:295-310. 2002
    ....
  59. pmc Effect of nitric oxide on mitochondrial respiratory activity of human articular chondrocytes
    E Maneiro
    Laboratory of Investigation, Rheumatology Division, Juan Canalejo Hospital, C Xubias 84, 15006 A Coruna, Spain
    Ann Rheum Dis 64:388-95. 2005
    ..To investigate the effect of nitric oxide (NO) on mitochondrial activity and its relation with the apoptosis of human articular chondrocytes...
  60. ncbi Low concentration of oxidant and nitric oxide donors stimulate proliferation of human endothelial cells in vitro
    Katarzyna Łuczak
    Department of Molecular Biophysics, University of Łódź, Banacha 12 13, 90 237 Lodz, Poland
    Cell Biol Int 28:483-6. 2004
    ..of human umbilical vein endothelial cells in vitro was inhibited by high concentrations of oxidants and nitric oxide donors but stimulated by low (micromolar or submicromolar) concentrations of hydrogen peroxide, menadione, tert-..
  61. ncbi Estradiol-induced expression of N(+)-K(+)-ATPase catalytic isoforms in rat arteries: gender differences in activity mediated by nitric oxide donors
    Javier Palacios
    Laboratory of Cellular and Molecular Physiology, School of Medicine, Universidad Los Andes, Santiago, Chile 6782468
    Am J Physiol Heart Circ Physiol 286:H1793-800. 2004
    ....
  62. ncbi Effects of nitric oxide on reactive oxygen species production and infarction size after brain reperfusion injury
    R M Pluta
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    Neurosurgery 48:884-92; discussion 892-3. 2001
    ..We hypothesized that, during reperfusion, exogenous nitric oxide (NO) would reduce stroke size by quenching ROS...
  63. ncbi Molecular mechanism of PC12 cell death evoked by sodium nitroprusside, a nitric oxide donor
    Magdalena Pytlowany
    Department of Cellular Signaling, Medical Research Centre, Polish Academy of Sciences, Warszawa, Poland
    Acta Biochim Pol 55:339-47. 2008
    ..The data demonstrate that NO liberated in excess decreases PARP-1 activity. Our results indicate that COX(s) and LOX(s) are involved in PC12 cell death evoked by NO released from its donor, SNP...
  64. ncbi DETA/NONOate, a nitric oxide donor, produces antidepressant effects by promoting hippocampal neurogenesis
    Yao Hua
    Department of Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, 210029, China
    Psychopharmacology (Berl) 200:231-42. 2008
    ..Our recent study shows that endogenous nitric oxide (NO) contributes to chronic mild stress (CMS)-induced depression by suppressing hippocampal neurogenesis...
  65. pmc Nitric oxide donor upregulation of stromal cell-derived factor-1/chemokine (CXC motif) receptor 4 enhances bone marrow stromal cell migration into ischemic brain after stroke
    Xu Cui
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    Stem Cells 25:2777-85. 2007
    ..Our data demonstrate that DETA-NONOate enhanced the therapeutic potency of BMSCs, possibly via upregulation of SDF1/CXCR4 and MMP pathways, and increased BMSC engraftment into the ischemic brain...
  66. ncbi Effects of nitric oxide on the contraction of skeletal muscle
    G Marechal
    Department of Physiology and Pharmacology, Faculty of Medicine, Catholic University of Louvain, Brussels, Belgium
    Cell Mol Life Sci 55:1088-102. 1999
    ..The general consequence of cGMP-mediated effects of NO is to improve mechanical and metabolic muscle power, similar to a transformation of slow-twitch to fast-twitch muscle, an effect that we may summarize as a 'slow-to-fast' shift...
  67. ncbi Carbon monoxide released by CORM-3 inhibits human platelets by a mechanism independent of soluble guanylate cyclase
    Stefan Chlopicki
    Department of Experimental Pharmacology, Chair of Pharmacology, Jagiellonian University Medical College, 31 531 Krakow 16 Grzegorzecka, Poland
    Cardiovasc Res 71:393-401. 2006
    ..Here we investigated the possible involvement of soluble guanylate cyclase in the anti-aggregatory effect of micromolar concentrations of CO released by a novel, water-soluble, CO releasing molecule (CORM) in human platelets...
  68. ncbi The effect of the nitric oxide donor sodium nitroprusside on glucose uptake in human primary skeletal muscle cells
    Darren C Henstridge
    Alfred and Baker Medical Unit, Baker IDI Heart and Diabetes Institute, Melbourne 8008, Vic, Australia
    Nitric Oxide 21:126-31. 2009
    ..These data confirm that nitric oxide donors have potential therapeutic utility to increase glucose uptake in humans, but that SNP only achieves this in ..
  69. ncbi Effect of nitric oxide synthase inhibitors on ovum transport and oviductal smooth muscle activity in the rat oviduct
    S Perez Martinez
    Centro de Estudios Farmacológicos y Botánicos CEFYBO CONICET, Buenos Aires, Argentina
    J Reprod Fertil 118:111-7. 2000
    ....
  70. ncbi Nitric oxide-induced endoplasmic reticulum stress activates the expression of cargo receptor proteins and alters the glycoprotein transport to the Golgi complex
    Maurizio Renna
    Dipartimento di Biochimica e Biotecnologie Mediche, University of Naples Federico II, Via S Pansini 5, 1 80131 Naples, Italy
    Int J Biochem Cell Biol 38:2040-8. 2006
    ....
  71. ncbi Combination of isosorbide dinitrate and hydralazine in blacks with heart failure
    Anne L Taylor
    Department of Medicine Cardiology, University of Minnesota Medical School, Minneapolis 55455, USA
    N Engl J Med 351:2049-57. 2004
    ..We examined whether a fixed dose of both isosorbide dinitrate and hydralazine provides additional benefit in blacks with advanced heart failure, a subgroup previously noted to have a favorable response to this therapy...
  72. ncbi Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition
    Guangwu Wang
    Department of Physiology, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Am J Physiol Heart Circ Physiol 288:H1290-5. 2005
    ..These data suggest that a critical process during NO donor-induced cardioprotection is to prevent MPT pore opening potentially via targeting of the adenine nucleotide translocator...
  73. ncbi Peroxynitrite-mediated oxidative damage to brain mitochondria: Protective effects of peroxynitrite scavengers
    Indrapal N Singh
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY 40536 0509, USA
    J Neurosci Res 85:2216-23. 2007
    ....
  74. ncbi Exogenous nitric oxide generates ROS and induces cardioprotection: involvement of PKG, mitochondrial KATP channels, and ERK
    Zhelong Xu
    Department of Anesthesiology, University of North Carolina, Chapel Hill, NC 27599 7010, USA
    Am J Physiol Heart Circ Physiol 286:H1433-40. 2004
    ..ROS and mitochondrial K(ATP) channels participate in the anti-infarct effect of SNAP. Moreover, phosphorylation of ERK is the downstream signaling event of ROS and plays a role in the cardioprotection of SNAP...
  75. ncbi Augmentation of intrapericardial nitric oxide level by a prolonged-release nitric oxide donor reduces luminal narrowing after porcine coronary angioplasty
    Sang Hong Baek
    Department of Medicine, Division of Cardiology, Indiana University Medical Center, Indianapolis, Ind, USA
    Circulation 105:2779-84. 2002
    ..The data suggest that intrapericardial delivery of NO donors for which NO release rates and pericardial residence times are matched and optimized might be a beneficial adjunct to coronary angioplasty...
  76. ncbi Are nitric oxide donors a valuable tool to study the functional role of nitric oxide in plant metabolism?
    M Arasimowicz-Jelonek
    Department of Plant Ecophysiology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland
    Plant Biol (Stuttg) 13:747-56. 2011
    ....
  77. ncbi Nitric oxide-donating aspirin inhibits colon cancer cell growth via mitogen-activated protein kinase activation
    Thomas R Hundley
    Division of Cancer Prevention, Department of Medicine, Life Sciences Bldg 06, State University of New York at Stony Brook, Stony Brook, NY 11794 5200, USA
    J Pharmacol Exp Ther 316:25-34. 2006
    ..Our data indicate that NO-aspirin is dependent on both the p38 and the JNK MAP kinase pathways for its ability to inhibit the growth of colon cancer cells...
  78. ncbi Inhalable microparticles of nitric oxide donors induce phagosome maturation and kill Mycobacterium tuberculosis
    Rahul Kumar Verma
    Pharmaceutics Division, CSIR Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226001, India
    Tuberculosis (Edinb) 93:412-7. 2013
    ..Gross morphology and histology of the lungs and spleen indicated that inhaled particles were well-tolerated. Inhalable MP containing NO donors need further investigation as an adjunct to standard anti-tuberculosis chemotherapy...
  79. ncbi Nitric-oxide-donating NSAIDs as agents for cancer prevention
    Basil Rigas
    Division of Cancer Prevention, Department of Medicine, SUNY at Stony Brook, Stony Brook, NY 11794 8160, USA
    Trends Mol Med 10:324-30. 2004
    ..The apparent safety and superior efficacy of NO-NSAIDs makes them promising chemopreventive agents against cancer...
  80. ncbi S-nitroso-N-acetylpenicillamine and nitroprusside induce apoptosis in a neuronal cell line by the production of different reactive molecules
    D Terwel
    Department of Psychiatry and Neuropsychology, European Graduate School of Neuroscience EURON, Maastricht University, P O Box 616, 6200 MD, Maastricht, Netherlands
    Eur J Pharmacol 400:19-33. 2000
    ....
  81. ncbi Novel therapeutic applications of nitric oxide donors in cancer: roles in chemo- and immunosensitization to apoptosis and inhibition of metastases
    Benjamin Bonavida
    Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1747, USA
    Nitric Oxide 19:152-7. 2008
    ..We have found that nitric oxide donors, similar to DETANONOate, inhibit cell survival anti-apoptotic pathways, such as the constitutively ..
  82. ncbi Assessment of ocular surface toxicity after topical instillation of nitric oxide donors
    Angelino Julio Cariello
    Department of Ophthalmology, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    Arq Bras Oftalmol 76:38-41. 2013
    To evaluate the ocular surface toxicity of two nitric oxide donors in ex vivo and in vivo animal models: S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylcysteine (SNAC) in a hydroxypropyl methylcellulose (HPMC) matrix at final ..
  83. ncbi The mechanisms responsible for neuroprotective capacity of arylpiperazine dopaminergic ligands against cell death induced by sodium nitroprusside
    Đurđica Ignjatović
    Department of Biochemistry, Institute for Biological Research, University of Belgrade, 142 Despot Stefana Blvd, 11060 Belgrade, Serbia
    Eur J Pharmacol 683:93-100. 2012
    ..It is postulated that neuroprotection was acquired also by elevation of endogenous glutathione or total superoxide dismutase activity...
  84. ncbi Exogenous nitric oxide donor and related compounds protect against lung inflammatory response after hemorrhagic shock and resuscitation
    Roberto Anaya-Prado
    Borgess Research Institute, Trauma, Surgery Research Sciences and Molecular Biology, the Departments of Surgery and Research, Michigan State University Kalamazoo Center for Medical Studies, Kalamazoo, Michigan, USA
    J Trauma 57:980-8. 2004
    ....
  85. pmc Experimental chemotherapy against Trypanosoma cruzi infection using ruthenium nitric oxide donors
    Jean Jerley N Silva
    Departamento de Quimica e Fisica Molecular, Instituto de Quimica de Sao Carlos Universidade de Sao Paulo, Sao Carlos, SP, Brazil
    Antimicrob Agents Chemother 53:4414-21. 2009
    ....
  86. ncbi Incubation of porcine iris-ciliary bodies to study the mechanisms by which nitric oxide donors lower intraocular pressure
    Hanna Kotikoski
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, University of Helsinki, Finland
    Med Sci Monit 9:BR1-7. 2003
    ..We previously reported that several nitric oxide (NO) donors, guanylate cyclase activators, and cyclic GMP lower intraocular pressure (IOP) in rabbits...
  87. ncbi Nitric oxide (NO) enhances pemetrexed cytotoxicity via NO‑cGMP signaling in lung adenocarcinoma cells in vitro and in vivo
    Hiroki Nagai
    Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto 606 8507, Japan
    Int J Oncol 41:24-30. 2012
    ..These findings suggest that NO donors, such as NOC-18 and GTN, enhance the anticancer effects of PEM by increasing the RFC1 and FPGS expression and stimulating cGMP signaling pathways in cancer cells...
  88. ncbi Modification of tubulin cysteines by nitric oxide and nitroxyl donors alters tubulin polymerization activity
    Lisa M Landino
    Department of Chemistry, The College of William and Mary, P O Box 8795, Williamsburg, Virginia 23187 8795, USA
    Chem Res Toxicol 20:1693-700. 2007
    ....
  89. ncbi No nitric oxide for HO-1 from sodium nitroprusside
    Henning Schroder
    Department of Pharmacology and Toxicology, School of Pharmacy, Martin Luther University, Halle, Germany
    Mol Pharmacol 69:1507-9. 2006
    ..This work not only helps revise concepts in NO and HO-1 research but also may direct future efforts to the role of iron and reactive oxygen species in the regulation of adenylyl cyclase...
  90. ncbi New nitric oxide donors based on ruthenium complexes
    C N Lunardi
    Laboratorio de Farmacologia, Departamento de Fisica e Quimica, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    Braz J Med Biol Res 42:87-93. 2009
    ..A growing amount of evidence supports the possibility that increased NO inactivation by excess O2- may account for the decreased NO bioavailability and vascular dysfunction in hypertension...
  91. ncbi Maturation alters cyclic nucleotide and relaxation responses to nitric oxide donors in ovine cerebral arteries
    Surya M Nauli
    Division of Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, Calif 92350, USA
    Biol Neonate 83:123-35. 2003
    ..Together, these findings emphasize that the cerebrovascular effects of NO are highly age dependent and artery specific, and should be carefully considered when administering NO therapeutically in the neonate...
  92. ncbi Antitumor platinum(II) complexes containing platinum-based moieties of present platinum drugs and furoxan groups as nitric oxide donors: synthesis, DNA interaction, and cytotoxicity
    Jian Zhao
    Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, China
    Inorg Chem 51:10317-24. 2012
    ..This finding is in accordance with the previous reports that NO hybrids show higher cytotoxicity against colon cancer cell lines compared with their parent compounds...
  93. ncbi Nitric oxide reverses prednisolone-induced inactivation of muscle satellite cells
    Jenna L Betters
    Center for Exercise Science, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
    Muscle Nerve 37:203-9. 2008
    ..05). Therefore, supplementation of GC myofibers with DETA-NO restores satellite cell activity to control levels. Nitric oxide production could be an important therapeutic target for the prevention of corticosteroid myopathy...
  94. ncbi Licofelone-nitric oxide donors as anticancer agents
    Wukun Liu
    College of Chemistry and Chemical Engineering, Hunan University, Changsha, P R China
    Arch Pharm (Weinheim) 344:487-93. 2011
    ..A correlation between COX inhibition and growth inhibitory properties is not visible. However, the high levels of nitric oxide production of the compounds may result in their high cytotoxic activity...
  95. ncbi Smad-interacting protein-1 and microRNA 200 family define a nitric oxide-dependent molecular circuitry involved in embryonic stem cell mesendoderm differentiation
    Jessica Rosati
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata IRCCS, Rome, Italy
    Arterioscler Thromb Vasc Biol 31:898-907. 2011
    ..Remarkably, SIP1/ZEB2 is a known target of the microRNA 200 (miR-200) family. In this light, we postulated that Sip1/ZEB2 and the miR-200 family could play a role during the NO-dependent differentiation of mES...
  96. pmc Haem and nitric oxide: synergism in the modulation of the endothelial haem oxygenase-1 pathway
    Roberta Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Biochem J 372:381-90. 2003
    ....
  97. ncbi Nitric oxide donors selectively reduce the expression of matrix metalloproteinases-8 and -9 by human diabetic skin fibroblasts
    Jamey W Burrow
    Department of Orthopaedics, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    J Surg Res 140:90-8. 2007
    ..In contrast, the concentration of nitric oxide (NO) is significantly reduced in these chronic ulcers. Addition of NO to diabetic wounds improves wound healing, but the mechanism for this effect is poorly understood...
  98. ncbi Divergent effects of nitric oxide donors on the biliary efflux transporters in isolated perfused rat livers: nitric oxide-independent inhibition of ABC transporters by sodium nitroprusside
    Ridhi Parasrampuria
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    Drug Metab Lett 5:64-72. 2011
    ..The observed inhibitory effects of SNP on the functions of both P-gp and Mrp2 are via an NO-independent mechanism...
  99. ncbi NO release by nitric oxide donors in vitro and in planta
    Luisa Ederli
    Department of Applied Biology, Borgo XX Giugno, 74, I 06121 Perugia, Italy
    Plant Physiol Biochem 47:42-8. 2009
    ..In spite of the different NO release signatures by SNP and NOS in tissue, the NO dependent responses examined were similar, suggesting that there is a critical threshold for the NO response...
  100. ncbi Nitric oxide synthase inhibitors and nitric oxide donors modulate the biosynthesis of thaxtomin A, a nitrated phytotoxin produced by Streptomyces spp
    Michael J Wach
    Department of Plant Pathology, Cornell University, Ithaca, NY 14853, USA
    Nitric Oxide 12:46-53. 2005
    ..Our data suggest that bacterial nitric oxide synthases may, at least in part, produce NO for biosynthetic purposes, rather than for cellular signaling, as they do in mammals...
  101. ncbi Activation of pig oocytes using nitric oxide donors
    Jaroslav Petr
    Research Institute for Animal Production, Prague, Uhrínìves, Czech Republic
    Mol Reprod Dev 71:115-22. 2005
    ..Also, the cleavage of parthenogenetic embryos was very low, and embryos did not develop beyond the stage of eight blastomeres...

Research Grants62

  1. ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGY
    Paul Kaufman; Fiscal Year: 2009
    ..pressure (IOP) reduction of other classes of potential glaucoma therapeutic agents (cannabinoids, nitric oxide donors, prostaglandin EP4 agonists, angiotensin and chymase), and their interactions with existing glaucoma ..
  2. PKG Redox Modulation of Cardiac Function and Disease
    DAVID ALAN KASS; Fiscal Year: 2013
    ..This indicates that therapies leveraging PKG activation, such as natriuretic peptides, nitric oxide donors, or PDE5-inhibitors, may themselves critically depend on PKG redox state...
  3. NITRIC OXIDE AND GASTROINTESTINAL OXIDATIVE INJURY
    Walee Chamulitrat; Fiscal Year: 1999
    ..Effects of nitric oxide donors on these parameters will give insights into the conditions which nitric oxide is protective or damaging...
  4. Novel therapy for female sexual dysfunction
    Garry Southan; Fiscal Year: 2001
    ..Topical application of traditional nitric oxide donors to the female genitalia, however, produces profound systemic side effects, including headache and ..
  5. Abnormalities in Keratoconus Corneas
    MARIA KENNEY; Fiscal Year: 2003
    ..Specific Aim #3 will address whether nitric oxide donors or peroxynitrites can affect the tyrosine phosphatase (LAR) or the tyrosine kinase (ErbBIPYK2/JNK) pathways...
  6. Flow-Mediated Dilation of Human Coronary Arterioles
    David D Gutterman; Fiscal Year: 2010
    ..This will be done using nitric oxide donors, measuring mitochondrial complex activity and ROS generation...
  7. RETINAL VASCULAR DYSFUNCTION FOLLOWING ISCHEMIA
    JEFFREY GIDDAY; Fiscal Year: 2000
    ..We will examine the efficacy of different oxygen free radical inhibitors and scavengers. nitric oxide donors, and TNF alpha inhibitors, in attenuating postischemic hypoperfusion, vascular leakage, impaired reactivity,..
  8. NITRIC OXIDE IN NORMAL AND DISEASED OCULAR MUSCLE
    HENRY KAMINSKI; Fiscal Year: 2000
    ..The effect of nitric oxide donors and nitric oxide synthase inhibitors on contractile function and evoked and miniature endplate potentials ..
  9. REACTIVE OXYGEN SPECIES AND HEMOGLOBIN-INDUCED INJURY
    ANN BALDWIN; Fiscal Year: 2003
    ..The effects of pretreatment with ROS scavengers, mast cell stabilizers, iron chelators and nitric oxide donors on intestinal endothelial and epithelial cell damage, and on formation of products of lipid peroxidation ..
  10. Preventing Resuscitation Injury and Improving Outcomes
    Richard Kerber; Fiscal Year: 2005
    ..Conversely, nitric oxide donors given during arrest and resuscitation exacerbate cardiac resuscitation injury by increasing toxic ..
  11. Unfolded protein response as a regulator of human beta-*
    John Corbett; Fiscal Year: 2005
    ..Experiments proposed will evaluate the effects of cytokines and nitric oxide donors on UPR activation and determine if UPR inhibition protects beta-cells from cytokine-mediated death. 2...
  12. COLLABORATIVE R01-CARDIAC GRAFTS-FUNCTIONAL ANALYSES
    Robert Kloner; Fiscal Year: 2003
    ....
  13. Biologic Ventricular Assist Device
    Robert Kloner; Fiscal Year: 2004
    ..Identification and characterization of transplants will be carried out with PCR analysis of the Y chromosome (male cells into female host), detailed histologic analysis and immunostaining for muscle cell markers. ..
  14. Mesenchymal Stem Cells for Myocardial Infarction
    Robert Kloner; Fiscal Year: 2006
    ..abstract_text> ..
  15. Nitroxyl and Nitric Oxide Producing Reactions of Hydroxyurea and Related Compound
    S Bruce King; Fiscal Year: 2010
    ..The results from these studies should enhance our ability to use HNO/NO donors as treatments for sickle cell disease, other anemias and congestive heart failure. . ..
  16. Assessment of the Chemical Biology of HNO via New Donors
    Katrina M Miranda; Fiscal Year: 2010
    ..Additionally, new biological targets, such as zinc fingers and non-heme iron centers, are likely to be revealed, which may suggest other therapeutic interventions. ..
  17. Prevention of Postmenopausal Bone Loss with Nitric Oxide
    Sunil Wimalawansa; Fiscal Year: 2007
    ..The study will also pave the way for the future, for providing more acceptable, affordable and cost- effective therapies for the prevention of postmenopausalosteoporosis. ..
  18. Botanicals for Treatment of Depression
    GREGORY THATCHER; Fiscal Year: 2006
    ..A long term goal of the project, is the development of an in vitro screen for identifying antidepressant botanicals. ..
  19. Mechanism of Metabolism of S-Nitrosothiols
    Neil Hogg; Fiscal Year: 2010
    ..Importantly, these studies will point to a role of RSNO formation not simply as 'carriers'of NO bioactivity but as a distinct bifurcation in NO signaling pathways. ..
  20. MECHANISMS OF NO-MEDIATED PROTEIN S-NITROSYLATION IN EAE
    OSCAR BIZZOZERO; Fiscal Year: 2007
    ..abstract_text> ..
  21. SUMMER RESEARCH EXPERIENCES FOR UNDERGRADUATES
    Neil Hogg; Fiscal Year: 2006
    ..The success of the program will be closely monitored by follow-up questionnaires to both students and participating faculty. ..
  22. Nitric oxide mimetic NSAIDs for treatment of Alzheimer's Disease
    GREGORY THATCHER; Fiscal Year: 2007
    ..This project will yield a drug candidate for which amyloid load will be measured in transgenic models in subsequent research, providing the impetus for moving this drug candidate from discovery to the clinic. [unreadable] [unreadable]..
  23. Caveolae and Anesthetic Induced Cardiac Protection
    David M Roth; Fiscal Year: 2010
    ..The proposed work will provide novel data with specific clinical implications for patients with myocardial ischemia or patients at high cardiac risk undergoing cardiac or noncardiac surgery. ..
  24. Cardiovascular Response to Glutamate Nitric Oxide
    WILLIAM TALMAN; Fiscal Year: 2006
    ..e. on nNOS immunoreactive dendrites or neurons in NTS. ..
  25. Nitric Oxide Tolerance in Smooth Muscle
    William Perkins; Fiscal Year: 2005
    ..We will use a combination of pharmacological probes and novel antisense oligomers to determine the mechanism by which chronic NO treatment decreases the expression and activity of sGC subunits and cGK isoforms. ..
  26. NITRIC OXIDE, PLP ACYLATION & THE PATHOPHYSIOLOGY OF MS
    OSCAR BIZZOZERO; Fiscal Year: 2003
    ..abstract_text> ..
  27. Elucidation of nitric oxide resistance mechanisms in motor neurons
    Amy Bishop; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  28. NICOTINE INDUCED CEREBROVASCULAR DYSFUNCTION
    WILLIAM MAYHAN; Fiscal Year: 2006
    ..In addition, results of these studies may provide insights regarding possible therapeutic approaches for the treatment of nicotine-induced vascular dysfunction. ..
  29. Interaction of COX-2 AND nNOS in renin secretion (R01)
    Tianxin Yang; Fiscal Year: 2008
    ..abstract_text> ..
  30. Endothelial Transduction of Shear Stress
    TIMOTHY NURKIEWICZ; Fiscal Year: 2003
    ..abstract_text> ..
  31. Nitric Oxide, Oxygen and Mechanical Stress in Cartilage
    Beverley Fermor; Fiscal Year: 2008
    ..Since mechanical stress is protective to ILl induced matrix breakdown we sha nvest gate if th s phenomenon is nfluenced by oxygen tension. ..
  32. AGING AND ENDOTHELIAL CELL FUNCTION
    May Reed; Fiscal Year: 2009
    ..The elucidation of mechanisms that regulate MMP activity in aged cells and tissues will assist the development of therapies to improve wound repair and revascularization of ischemic organs. ..
  33. Endothelial reactivity and nitric oxide synthetase activity in the ALMS (Aspreva
    Robert Clancy; Fiscal Year: 2009
    ..Relevance to public health: The association of markers/indices of NOS2 expression with mechanism of action of a successful drug treatment in lupus nephritis would be a major advance. ..
  34. Salt Absorption by the THAL: Role of NKCC2 trafficking
    Pablo A Ortiz; Fiscal Year: 2010
    ..Data from this proposal will increase our understanding of how salt absorption by the THAL is regulated in normal and salt-sensitive animals, and will identify new targets for the development of diuretics. ..
  35. NOS-INDEPENDENT NO PRODUCTION IN THE NERVOUS SYSTEM
    Leonid Moroz; Fiscal Year: 2002
    ..Thus, significant gains can be made in our understanding of the synthesis of this gaseous messenger in the brain. This work will also contribute to our understanding of the neural functions in normal and pathological conditions. ..
  36. Cardiac myofibroblasts in autoimmune-associated CHB
    Robert Clancy; Fiscal Year: 2002
    ....
  37. REGULATION OF EXPRESSION OF NO SYNTHASE
    Louis Ignarro; Fiscal Year: 2002
    ..The proposed research represents a continuing long-term effort to elucidate the biological factors influencing the vascular and related actions of NO in health and disease. ..
  38. G PROTEINS AND PAROTID SECRETORY GRANULE
    EILEEN WATSON; Fiscal Year: 2002
    ..These studies will also provide a framework for examining cellular biochemical defects in diseases relating to salivary dysfunction. ..
  39. NOS1/NOS3 Functional Effects on Cardiac Myocyte Function
    Mark T Ziolo; Fiscal Year: 2010
    ..The relevance of this proposal to public health is that these results may improve the treatment of heart disease by potentially identifying new targets for drug development. ..
  40. HPLC DETECTION OF RADICAL INTERMEDIATES
    Detcho Stoyanovsky; Fiscal Year: 2002
    ..The method is expected to display several orders of magnitude higher sensitivity than then traditional ESR spin trapping technique and may be a new approach in assays of oxidative stress. ..
  41. HYPOXIA AND HEPATIC FIBROGENESIS
    Victor Ankoma Sey; Fiscal Year: 2002
    ..abstract_text> ..
  42. Vasoactive Peptides that Stimulate Smooth Muscles
    RANDAL A contact SKIDGEL; Fiscal Year: 2010
    ..abstract_text> ..
  43. Nitric Oxide-Mediated Pulmonary Vasodilation After Chronic Hypoxia
    Thomas Resta; Fiscal Year: 2007
    ..Findings from studies are expected to fundamentally advance our understanding of signal transduction mechanisms by which PKG regulates pulmonary vascular tone, as well as adaptive responses of the pulmonary circulation to CH. ..
  44. Cyclic AMP signaling in cardiac myocytes
    THOMAS RICH; Fiscal Year: 2007
    ..g., protenoid, beta1-,or beta2-adrenergic receptors) or inhibit phosphodiesterase (PDE) will shed new light on the physiologic functions of these enzymes and their relation to cardiac function. ..
  45. MECHANICAL STRESS AND PROSTAGLANDINS IN CARTILAGE
    Beverley Fermor; Fiscal Year: 2003
    ..The findings will have significant implications in the development of pharmaceutical or biophysical interventions for the treatment of arthritis. ..
  46. Excitatory Amino Acid Release in Ischemia
    HAROLD KIMELBERG; Fiscal Year: 2005
    ..The second half of the project that deals with neuroprotection has direct potential clinical implications, as TAM is known to be well tolerated in humans being widely used for breast cancer treatment. ..
  47. Toxicokinetics and Toxicodynamics of GHB and Precursors
    Ho Leung Fung; Fiscal Year: 2004
    ..A pharmacogenetic mapping of the pharmacological effects of GHB will be obtained. The effects of tolerance development, withdrawal, gender, receptor blockade on these effects will be examined. ..
  48. Signaling for cardioprotection against oxidative stress
    Yuichiro Suzuki; Fiscal Year: 2006
    ..In addition, it is expected that the results will fundamentally advance the field of cardiac muscle cell biology. ..
  49. Aging, aortic stiffness, and intracellular signaling.
    Eric Blough; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  50. Regulation of Hypoxia Inducible Factor-1 by Nitric Oxide
    Lisa Palmer; Fiscal Year: 2004
    ..At the completion of this project, we believe we will have identified several new targets for the prevention and treatment of hypoxia- induced and primary pulmonary hypertension. ..
  51. ALCOHOL, ACETAMINOPHEN, AND LIVER SINUSOID DYSFUNCTION
    ROBERT MC CUSKEY; Fiscal Year: 2004
    ..A better knowledge of the hepatic pathophysiology of alcohol bringing also should result. ..
  52. ASTROCYTE-DERIVED NITRIC OXIDE IN THE CNS
    Sean Murphy; Fiscal Year: 2003
    ..These studies will not only reveal roles for NO in the onset and recovery from damage following ischemia but may also provide the basis for novel and rational therapeutics. ..
  53. HEPATIC CARCINOGENESIS: MOLECULAR MECHANISMS
    Martina Buck; Fiscal Year: 2006
    ..abstract_text> ..
  54. ESTROGEN/SYMPATHETIC VASOCONSTRICTION IN SKELETAL MUSCLE
    Gail Thomas; Fiscal Year: 2003
    ....
  55. Generation of Collecting Duct Knockout of PPARgamma
    Tianxin Yang; Fiscal Year: 2006
    ..New information provided by this proposal is expected to provide insights into the roles of PPARgamma in regulation of fluid balance and in mediation of the side effects of TDZ. ..
  56. EPR IMAGING OF TUMOR HETEROGENEITY AND OXYGENATION
    Periannan Kuppusamy; Fiscal Year: 2003
    ..Information obtained from these studies should enable the development and optimization of therapeutic modalities for cancer treatment. ..
  57. Afferent modulation in bladde dysfunction
    Naoki Yoshimura; Fiscal Year: 2007
    ..abstract not provided ..
  58. Regulation of Airway Goblet Cell Mucin Secretion
    C Davis; Fiscal Year: 2007
    ..abstract_text> ..
  59. Role of Cytokines and Promoter Genotype in Prematurity
    Hyagriv Simhan; Fiscal Year: 2007
    ..abstract_text> ..
  60. A molecular target for nutrients in the prostate
    JEFFREY LASKIN; Fiscal Year: 2007
    ..We will also assess the effects of dietary nutrients on this enzyme activity in prostate cells. These studies will provide important information on a unique target for chemopreventative agents in the prostate. ..
  61. PULMONARY VASODILATION AND GUANYLATE CYCLASE REGULATION
    Michael S Wolin; Fiscal Year: 2010
    ....