serotonin agents

Summary

Summary: Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin receptors, the life cycle of serotonin, and the survival of serotonergic neurons.

Top Publications

  1. ncbi Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions
    Mark J Millan
    Institut de Recherche Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Trends Pharmacol Sci 29:454-64. 2008
  2. ncbi Acute behavioural and neurotoxic effects of MDMA plus cocaine in adolescent mice
    M Daza-Losada
    Departamento de Psicobiologia, Facultad de Psicologia, Universitat de Valencia, Valencia, 46010, Spain
    Neurotoxicol Teratol 31:49-59. 2009
  3. ncbi Local 5,7-dihydroxytryptamine lesions of rat amygdala: release of punished drinking, unaffected plus-maze behavior and ethanol consumption
    W Sommer
    Addiction Centre South, Dept of NEUROTEC, Karolinska Institute, Stockholm, Sweden
    Neuropsychopharmacology 24:430-40. 2001
  4. ncbi Dual 5-HT mechanisms in basolateral and central nuclei of amygdala in the regulation of the defensive behavior induced by electrical stimulation of the inferior colliculus
    Carlos Eduardo Macedo
    Laboratorio de Psicobiologia, Faculdade Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP Brazil
    Brain Res Bull 59:189-95. 2002
  5. ncbi Differential involvement of 5-HT projections within the amygdala in prepulse inhibition but not in psychotomimetic drug-induced hyperlocomotion
    Snezana Kusljic
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, VIC 3052, Australia
    Behav Brain Res 168:74-82. 2006
  6. ncbi Ecstasy: are animal data consistent between species and can they translate to humans?
    Neil Easton
    School of Biomedical Science, University of Nottingham, Queen s Medical Centre, UK
    J Psychopharmacol 20:194-210. 2006
  7. pmc Effect of the CB1 cannabinoid agonist WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference in mice
    Carmen Manzanedo
    Departamento de Psicobiologia, Universitat de Valencia, Spain
    Behav Brain Funct 6:19. 2010
  8. ncbi Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition
    Rafael de la Torre
    Unitat de Recerca en Farmacologia, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Ther Drug Monit 26:137-44. 2004
  9. ncbi Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific
    H F Clarke
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Cereb Cortex 17:18-27. 2007
  10. ncbi Auditory event-related potentials (P3) and cognitive performance in recreational ecstasy polydrug users: evidence from a 12-month longitudinal study
    Susana de Sola
    Behavioral Neurology and Dementia Section, Neurology Department, Hospital del Mar, Universitat Autonoma de Barcelona, Passeig Maritim, 25 29, 08003 Barcelona, Spain
    Psychopharmacology (Berl) 200:425-37. 2008

Research Grants

  1. Serotonergic Contribution to Adolescent Risk Taking
    ANDREW EMMETT ARRANT; Fiscal Year: 2012
  2. Serotonin Club Meeting 2010
    JULIE GORTON HENSLER; Fiscal Year: 2010
  3. ELECTROANALYSIS OF NEUROTRANSMITTERS AND MODULATORS
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
  4. Exploring the role of the central amygdala in vocalization
    IAN CHRISTOPHER HALL; Fiscal Year: 2013
  5. Neuromodulation of cortical circuits in health and disease
    Allan T Gulledge; Fiscal Year: 2013
  6. Methylphenidate, Serotonin and Dopamine Interactions
    Sara R Jones; Fiscal Year: 2013
  7. Cerebellar Neuromodulation
    Kamran Khodakhah; Fiscal Year: 2013
  8. Neurobiological Bases of Placebo Response in Major Depressive Disorder
    Cristina Cusin; Fiscal Year: 2013
  9. Serotonin Club IUPHAR Satellite Meeting
    Mark Geyer; Fiscal Year: 2006
  10. GENETIC AND BIOCHEMICAL DISSECTION OF PROLACTIN ACTIONS
    NELSON HORSEMAN; Fiscal Year: 2006

Detail Information

Publications234 found, 100 shown here

  1. ncbi Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions
    Mark J Millan
    Institut de Recherche Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Trends Pharmacol Sci 29:454-64. 2008
    ..In view of the diversity of transduction mechanisms engaged by 5-HT, much of this discussion is relevant to other classes of G-protein-coupled receptors...
  2. ncbi Acute behavioural and neurotoxic effects of MDMA plus cocaine in adolescent mice
    M Daza-Losada
    Departamento de Psicobiologia, Facultad de Psicologia, Universitat de Valencia, Valencia, 46010, Spain
    Neurotoxicol Teratol 31:49-59. 2009
    ..In conclusion, the combined use of MDMA and cocaine produces a predominance of serotonin over DA, which is associated with an anxiolytic profile, defensive behaviours and fewer social contacts...
  3. ncbi Local 5,7-dihydroxytryptamine lesions of rat amygdala: release of punished drinking, unaffected plus-maze behavior and ethanol consumption
    W Sommer
    Addiction Centre South, Dept of NEUROTEC, Karolinska Institute, Stockholm, Sweden
    Neuropsychopharmacology 24:430-40. 2001
    ....
  4. ncbi Dual 5-HT mechanisms in basolateral and central nuclei of amygdala in the regulation of the defensive behavior induced by electrical stimulation of the inferior colliculus
    Carlos Eduardo Macedo
    Laboratorio de Psicobiologia, Faculdade Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP Brazil
    Brain Res Bull 59:189-95. 2002
    ..It is likely that aversive information ascending from the inferior colliculus may receive either inhibitory or excitatory influences of 5-HT mechanisms in the BLA or CeA, respectively...
  5. ncbi Differential involvement of 5-HT projections within the amygdala in prepulse inhibition but not in psychotomimetic drug-induced hyperlocomotion
    Snezana Kusljic
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, VIC 3052, Australia
    Behav Brain Res 168:74-82. 2006
    ..Thus, the present study supports the view that 5-HT in the amygdala may be involved in aspects of schizophrenia and a target for antipsychotic drug action...
  6. ncbi Ecstasy: are animal data consistent between species and can they translate to humans?
    Neil Easton
    School of Biomedical Science, University of Nottingham, Queen s Medical Centre, UK
    J Psychopharmacol 20:194-210. 2006
    ..Consideration is also given to the role of neurotoxic metabolites and the influence of age, sex and user groups on the long-term actions of MDMA...
  7. pmc Effect of the CB1 cannabinoid agonist WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference in mice
    Carmen Manzanedo
    Departamento de Psicobiologia, Universitat de Valencia, Spain
    Behav Brain Funct 6:19. 2010
    ..The aim of the present study was to evaluate, using the conditioned place preference, the effect of the cannabinoid agonist WIN 55,212-2 on the rewarding effects of MDMA in mice...
  8. ncbi Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition
    Rafael de la Torre
    Unitat de Recerca en Farmacologia, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Ther Drug Monit 26:137-44. 2004
    ..One of the interesting features of MDMA metabolism is its potential involvement in the development of mid- to long-term neurotoxic effects as a result of progressive neurodegeneration of the serotonergic neurotransmission system...
  9. ncbi Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific
    H F Clarke
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Cereb Cortex 17:18-27. 2007
    ....
  10. ncbi Auditory event-related potentials (P3) and cognitive performance in recreational ecstasy polydrug users: evidence from a 12-month longitudinal study
    Susana de Sola
    Behavioral Neurology and Dementia Section, Neurology Department, Hospital del Mar, Universitat Autonoma de Barcelona, Passeig Maritim, 25 29, 08003 Barcelona, Spain
    Psychopharmacology (Berl) 200:425-37. 2008
    ..In humans, long-term recreational use of ecstasy has been mainly associated with memory impairment...
  11. ncbi Serotonin/dopamine interaction in learning
    María Esther Olvera-Cortés
    Laboratorio de Neurofisiología Experimental, Centro de Investigacion Biomedica de Michoacan, Instituto Mexicano del Seguro Social, Morelia, Mexico
    Prog Brain Res 172:567-602. 2008
    ..The complete significance of DA-serotonin interactions in cognitive functions could be addressed by future experimental and clinical studies...
  12. ncbi 5,7-dihydroxytryptamine injections into the prefrontal cortex and nucleus accumbens differently affect prepulse inhibition and baseline startle magnitude in rats
    Daniela Mohr
    Animal Physiology, University of Tubingen, Tubingen, Germany
    Behav Brain Res 202:58-63. 2009
    ..However, the observed changes cannot be attributed to a specific brain site since our data clearly show that local 5,7-dihydroxytryptamine injections also affect transmitter levels in brain sites away from the injection site...
  13. ncbi Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies
    Mark John Millan
    Institut de Recherches Servier, Croissy sur Seine, France
    Therapie 60:441-60. 2005
    ....
  14. ncbi Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 29:1331-43. 2004
    ..However, not all measures of impulsivity appear to be uniformly affected by 5-HT depletion, or correlate with each other, supporting the suggestion that impulsivity is not a unitary construct...
  15. ncbi Elevation of ambient room temperature has differential effects on MDMA-induced 5-HT and dopamine release in striatum and nucleus accumbens of rats
    Esther O'Shea
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Neuropsychopharmacology 30:1312-23. 2005
    ....
  16. ncbi The effects of fluoxetine on the subjective and physiological effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans
    Manuel Tancer
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, 2761 E Jefferson St, Detroit, MI 48207, USA
    Psychopharmacology (Berl) 189:565-73. 2007
    ..The purpose of this study was to investigate the role of serotonin (5-HT) in the effects of oral 3,4-methylenedioxymethamphetamine (MDMA) in humans...
  17. ncbi Serotonergic drugs : effects on appetite expression and use for the treatment of obesity
    Jason C G Halford
    Kissileff Laboratory for the Study of Human Ingestive Behaviour, School of Psychology, University of Liverpool, Liverpool, UK
    Drugs 67:27-55. 2007
    ..The hope is that these drugs will not only be free of their predecessors' adverse effect profiles, but will also be equally or more effective at regulating appetite and controlling bodyweight...
  18. ncbi Serotonin receptors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders
    Bryan L Roth
    Department of Biochemistry, and NIMH Psychoactive Drug Screening Program, Case Western Reserve University Medical School, 2109 Adelbert Road, Cleveland, OH 44106, USA
    Psychopharmacology (Berl) 174:17-24. 2004
    ..This review provides evidence for and against the use of selective 5-HT receptor drugs as cognition enhancing agents for schizophrenia and other disorders...
  19. ncbi Serotonin delivery into the ventromedial nucleus of the hypothalamus affects differently feeding pattern and body weight in obese and lean Zucker rats
    Serguei O Fetissov
    Neuroscience Program, Surgical Metabolism and Nutrition Laboratory, Department of Surgery, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Appetite 54:346-53. 2010
    ..To determine if central serotonin (5-HT)-induced satiety is altered in obesity...
  20. ncbi Effect of fenfluramine-derivative diet pills on cardiac valves: a meta-analysis of observational studies
    Molly Sachdev
    Duke Clinical Research Institute and the School of Medicine, Duke University, Durham, NC, USA
    Am Heart J 144:1065-73. 2002
    ..We systematically reviewed evidence regarding the prevalence of valvular disease after fenfluramine exposure...
  21. ncbi Activation of central melanocortin pathways by fenfluramine
    Lora K Heisler
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 297:609-11. 2002
    ..These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective anti-obesity treatments...
  22. ncbi Effects of ethanol and 3,4-methylenedioxymethamphetamine (MDMA) alone or in combination on spontaneous and evoked overflow of dopamine, serotonin and acetylcholine in striatal slices of the rat brain
    Céline Riegert
    Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Universität Freiburg, Neuropharmakologisches Labor, Freiburg, Germany
    Int J Neuropsychopharmacol 11:743-63. 2008
    ..These data do not preclude the contribution of other pharmacodynamic and/or pharmacokinetic mechanisms in vivo but support the hypothesis that EtOH may affect the abuse liability of MDMA...
  23. pmc Serotonergic neurotoxic thioether metabolites of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"): synthesis, isolation, and characterization of diastereoisomers
    Nieves Pizarro
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona Health Sciences Center, Tucson, Arizona 85721, USA
    Chem Res Toxicol 21:2272-9. 2008
    ....
  24. ncbi Administration of neurotoxic doses of MDMA reduces sensitivity to ethanol and increases GAT-1 immunoreactivity in mice striatum
    Maria Izco
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense, Madrid 28040, Spain
    Psychopharmacology (Berl) 207:671-9. 2010
    ..In keeping with human studies and other animal models where alcohol consumption and preference are also high, MDMA treatment will reduce sensitivity to certain physiological effects of EtOH...
  25. ncbi Clinical and echocardiographic follow-up of patients previously treated with dexfenfluramine or phentermine/fenfluramine
    J M Gardin
    Division of Cardiology, St John Hospital and Medical Center, 22201 Moross Rd, PB II, Suite 470, Detroit, MI 48236, USA
    JAMA 286:2011-4. 2001
    ..Use of anorexigen therapy is associated with valvular abnormalities, although there is limited information on long-term changes in valvular regurgitation following discontinuation of these agents...
  26. pmc Long-term behavioral consequences of prenatal MDMA exposure
    Valerie B Thompson
    Neuroscience Graduate Program, University of Cincinnati, 231 Albert Sabin Way, CVC Room 5940, ML 0537, Cincinnati, OH 45267, USA
    Physiol Behav 96:593-601. 2009
    ....
  27. ncbi Use of serotonergic drugs and the risk of bleeding
    B M Verdel
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Clin Pharmacol Ther 89:89-96. 2011
    ..The association between antipsychotic drugs and gastrointestinal bleeding may warrant further research, in view of the fact that this association was rather unexpected...
  28. ncbi Selective destruction of brain serotonin neurons by 5,7-dihydroxytryptamine increases responding for a conditioned reward
    P J Fletcher
    Department of Psychiatry, University of Toronto, Ontario, Canada
    Psychopharmacology (Berl) 147:291-9. 1999
    ..Previously, we have shown that increasing 5-hydroxytryptamine (5-HT) activity attenuates responding for conditioned reward (CR), and the response potentiating effect of d-amphetamine on this behaviour...
  29. pmc Pharmacological targeting of the serotonergic system for the treatment of obesity
    Alastair S Garfield
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    J Physiol 587:49-60. 2009
    ..Here we review serotonergic compounds reducing ingestive behaviour and discuss their clinical potential for the treatment of obesity...
  30. ncbi Serotonin depletion attenuates cocaine seeking but enhances sucrose seeking and the effects of cocaine priming on reinstatement of cocaine seeking in rats
    L T Tran-Nguyen
    Department of Psychology, Arizona State University, Box 871104, Tempe, AZ 85287 1104, USA
    Psychopharmacology (Berl) 157:340-8. 2001
    ..Acute serotonin (5-HT) depletion by the tryptophan hydroxylase inhibitor, para-chlorophenylalanine, attenuates cocaine seeking in rats...
  31. ncbi Prefrontal serotonin depletion affects reversal learning but not attentional set shifting
    H F Clarke
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 25:532-8. 2005
    ....
  32. ncbi Serotonin releasing agents. Neurochemical, therapeutic and adverse effects
    Richard B Rothman
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, P O Box 5180, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Pharmacol Biochem Behav 71:825-36. 2002
    ..Viewed collectively, it seems possible to develop new medications that selectively release 5-HT without the adverse effects of PPH, VHD or neurotoxicity. Such agents may have utility in treating a variety of psychiatric disorders...
  33. ncbi Echocardiographic examination of women previously treated with fenfluramine: long-term follow-up of a randomized, double-blind, placebo-controlled trial
    R Davidoff
    Section of Cardiology C8, Boston University Medical Center, 88 E Newton St, Boston, MA 02118 2393, USA
    Arch Intern Med 161:1429-36. 2001
    ..The prevalence of echocardiographic abnormalities and the clinical cardiovascular status of patients who received fenfluramine monotherapy remains uncertain...
  34. ncbi Role of serotonin1A receptors on the modulation of rat spinal mono-synaptic reflexes in vitro
    Gonzalo Hedo
    Department of Physiology, Edificio de Medicina, University of Alcala, 28871 Madrid, Spain
    Neurosci Lett 334:41-4. 2002
    ..The results are consistent with an intervention of 5-HT(1A) receptors in the modulation of non-nociceptive reflexes but do not support a prominent role for this receptor in the modulation of nociceptive reflexes...
  35. ncbi Serotonergic modulation of carbachol-induced rhythmic activity in hippocampal slices
    Michael Krause
    Tensor Biosciences, Irvine, CA 92612, USA
    Neuropharmacology 48:381-90. 2005
    ..These results strongly implicate 5-HT(1A) and 5-HT(2) receptors in the modulation of spectral power of carbachol-induced rhythmic activity and that 5-HT(1A) receptors are responsible for the prevailing effect of 5-HT...
  36. pmc An assay to evaluate the long-term effects of inflammatory mediators on murine airway smooth muscle: evidence that TNFalpha up-regulates 5-HT(2A)-mediated contraction
    Mikael Adner
    Department of Otorhinolaryngology, Malmo University Hospital, SE 20502 Malmo, Sweden
    Br J Pharmacol 137:971-82. 2002
    ..The time-dependent effect of TNFalpha indicates the importance of studying the long-term effect of cytokines on the smooth muscle cells in relation to airway hyperresponsiveness and remodelling...
  37. ncbi Host brain regulation of dopaminergic grafts function: role of the serotonergic and noradrenergic systems in amphetamine-induced responses
    Ana Munoz
    Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Spain
    Synapse 47:66-76. 2003
    ..However, indirect effects exerted by the noradrenergic system on the normal striatum were not observed in the DA-denervated and grafted striata...
  38. ncbi Comparing sertindole to other new generation antipsychotics on preferential dopamine output in limbic versus striatal projection regions: mechanism of action
    Peter Hertel
    Department of Psychopharmacology, H Lundbeck A S, Ottiliavej 9, DK 2500 Copenhagen Valby, Denmark
    Synapse 60:543-52. 2006
    ..For some compounds, blockade of D4 receptors may also play a role in this regard...
  39. ncbi Modification of cocaine-induced behavioral and neurochemical effects by serotonin1A receptor agonist/antagonist in mice
    Shigeo Nakamura
    Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    Synapse 60:479-84. 2006
    ..These results suggest that the prefrontal 5-HT system plays a pivotal role in the locomotor stimulant effect of cocaine in mice...
  40. ncbi Melatonin potentiates 5-HT(1A) receptor activation in rat hypothalamus and results in hypothermia
    Mao tsun Lin
    Department of Medical Research, Chi Mei Medical Center, Yung Kang City, Tainan Hsien, Taiwan
    J Pineal Res 33:14-9. 2002
    ..The data indicate that melatonin potentiates the 5-HT1A receptor activation in the hypothalamus and results in hypothermic effects which can be antagonized by the expected hyperthermic effect of DOI...
  41. ncbi A novel mechanism involved in 5-hydroxytryptamine-induced nociception: the indirect activation of primary afferents
    C H Tambeli
    Department of Physiology, Laboratory of Orofacial Pain, Faculty of Dentistry of Piracicaba, University of Campinas, UNICAMP, 901 Limeira Avenue, Piracicaba, São Paulo 13414 900, Brazil
    Neuroscience 141:1517-24. 2006
    ..Based on that it is proposed that dopamine, once released, activates D1 and beta1-adrenergic receptors to contribute to 5-hydroxytryptamine-induced nociception...
  42. ncbi The role of 5-HT in the impairment of thermoregulation observed in rats administered MDMA ('ecstasy') when housed at high ambient temperature
    Kathryn S Saadat
    Neuropharmacology Research Group, Leicester School of Pharmacy, De Montfort University, The Gateway Leicester, LE1 9BH, UK
    Psychopharmacology (Berl) 179:884-90. 2005
    ....
  43. ncbi In vivo effect of tramadol on locus coeruleus neurons is mediated by alpha2-adrenoceptors and modulated by serotonin
    Esther Berrocoso
    Pharmacology and Neuroscience Research Group, Department of Neuroscience Pharmacology and Psychiatry, School of Medicine, University of Cadiz, Plaza Falla 9, E 11003 Cádiz, Spain
    Neuropharmacology 51:146-53. 2006
    ..In summary, the results indicate that tramadol elicits an inhibitory effect on LC neurons in vivo through alpha(2)-adrenoceptors. Moreover, this effect is modulated by the 5-HT system and particularly by 5-HT(1A) receptors...
  44. ncbi Serotonin transporter expression is not sufficient to confer cytotoxicity to 3,4-methylenedioxymethamphetamine (MDMA) in vitro
    Shaista Hayat
    Laboratory of Molecular Signalling, The Babraham Institute, Cambridge, UK
    J Psychopharmacol 20:257-63. 2006
    ..We conclude that SERT expression is not sufficient to confer MDMA toxicity to cell lines. Therefore SERT-expressing cell lines do not offer a simple model system to elucidate the mechanisms underlying MDMA toxicity...
  45. ncbi Pharmacological characterization of serotonergic receptor activity in the hypoglossal nucleus
    Polina Fenik
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Respir Crit Care Med 167:563-9. 2003
    ..There is no evidence for serotonin 7 activity in the hypoglossal nucleus. This characterization of serotonin receptor subtypes in the hypoglossal nucleus provides a focus for the development of pharmacotherapies for sleep apnea...
  46. ncbi Neuropharmacology and neurotoxicity of 3,4-methylenedioxymethamphetamine
    Gary A Gudelsky
    College of Pharmacy, University of Cincinnati, Cincinnati, OH, USA
    Methods Mol Med 79:55-73. 2003
    ....
  47. ncbi Studies on striatal neurotoxicity caused by the 3,4-methylenedioxymethamphetamine/ malonate combination: implications for serotonin/dopamine interactions
    Beatriz Goni-Allo
    Department of Pharmacology, School of Medicine, University of Navarra, Pamplona, Spain
    J Psychopharmacol 20:245-56. 2006
    ..Overall, these results suggest that the synergic release of dopamine caused by the malonate/MDMA combination plays an important role in the long-term toxic effects. A possible mechanism of neurotoxicity and protection is proposed...
  48. ncbi Serotonin reuptake inhibitors do not prevent 5,7-dihydroxytryptamine-induced depletion of serotonin in rat brain
    SuJean Choi
    Department of Neuroscience, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain Res 1007:19-28. 2004
    ....
  49. ncbi Effect of 5-hydroxytryptamine on neurogenic vasoconstriction in the isolated, autoperfused hindquarters of the rat
    E Calama
    Laboratorio de Farmacognosia y Farmacología, Departamento de Fisiologia y Farmacologia, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
    Clin Exp Pharmacol Physiol 32:894-900. 2005
    ....
  50. ncbi Increased behavioural activity of rats in forced swimming test after partial denervation of serotonergic system by parachloroamphetamine treatment
    Riina Häidkind
    Department of Psychology, University of Tartu, Tiigi 78, 50410 Tartu, Estonia
    Neurochem Int 45:721-32. 2004
    ....
  51. ncbi Depression of mGluR-mediated IPSCs by 5-HT in dopamine neurons of the rat substantia nigra pars compacta
    E Paolucci
    Fondazione Santa Lucia IRCCS, Experimental Neurology, Via Ardeatina 306, 00179 Rome, Italy
    Eur J Neurosci 18:2743-50. 2003
    ..Our results demonstrate a powerful inhibition of the mGluR-IPSC by 5-HT in midbrain dopamine neurons, most probably through stimulation of 5-HT2A and 5-HT4 receptors...
  52. ncbi Long-lasting behavioral sensitization to psychostimulants following p-chloroamphetamine-induced neurotoxicity in mice
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences R 629, University of Miami School of Medicine, Miami, FL 33136
    Neuropharmacology 46:74-84. 2004
    ..These findings may be relevant to the psychopathology of amphetamines-induced neurotoxicity...
  53. ncbi 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis
    Sietse F de Boer
    Department of Behavioral Physiology, Biological Center, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Eur J Pharmacol 526:125-39. 2005
    ....
  54. ncbi Modulation of anxiety circuits by serotonergic systems
    Christopher A Lowry
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
    Stress 8:233-46. 2005
    ....
  55. ncbi Central serotonin depletion affects rat brain areas differently: a qualitative and quantitative comparison between different treatment schemes
    Birgitte Rahbek Kornum
    Neurobiology Research Unit, N9201, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, Denmark
    Neurosci Lett 392:129-34. 2006
    ..While the pattern of 5-HT depletion using pCPA alone was comparable to the one seen with the combined treatment, the 5-HT depletion using FEN alone showed a different pattern with 5-HT distributed in several brain regions...
  56. ncbi High-dose fenfluramine administration decreases serotonin transporter binding, but not serotonin transporter protein levels, in rat forebrain
    Richard B Rothman
    Clinical Psychopharmacology Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Synapse 50:233-9. 2003
    ..These results support the hypothesis that decreases in tissue 5-HT and SERT binding sites induced by D-FEN and PCA reflect neuroadaptive changes, rather than neurotoxic effects...
  57. ncbi Effects of fenfluramine and antidepressants on protein kinase C activity in rat cortical synaptoneurosomes
    Cecilia T Giambalvo
    Rhode Island Psychiatric Research Center, Eleanor Slater Hospital, Cranston, Rhode Island 02920, USA
    Synapse 50:212-22. 2003
    ..These results, showing that D-fenfluramine altered PKC activity similar to D-amphetamine, suggest that the topographic homology between DAT and SERT may extend to their effects on PKC activity...
  58. ncbi Endogenous 5-HT, released by MDMA through serotonin transporter- and secretory vesicle-dependent mechanisms, reduces hippocampal excitatory synaptic transmission by preferential activation of 5-HT1B receptors located on CA1 pyramidal neurons
    Boris Mlinar
    Department of Preclinical and Clinical Pharmacology Mario Aiazzi Mancini University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Eur J Neurosci 18:1559-71. 2003
    ..Thus although the SERT reversal contributes, a direct vesicle-depleting action is essential for MDMA release of 5-HT...
  59. ncbi [3,4-methylenedioxymethamphetamine ('ecstasy'): its long-term emotional and cognitive effects, and serotonin depletion]
    A Molero-Chamizo
    Departamento de Psicología y Fisiología del Comportamiento, Universidad de Granada, Granada, Spain
    Rev Neurol 41:108-14. 2005
    ....
  60. ncbi Comparison of effects of dual transporter inhibitors on monoamine transporters and extracellular levels in rats
    Susanne Koch
    Lilly Neuroscience Research Division, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Neuropharmacology 45:935-44. 2003
    ..Chlorimipramine, duloxetine, and high dose venlafaxine acted as dual transporter inhibitors in rat PFC and increased extracellular concentrations of the monoamines, indicating functional dual transporter inhibition...
  61. ncbi Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells
    Cécile Mahé
    Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, WSJ 386 7 44, CH 4002 Basel, Switzerland
    Neuropharmacology 49:40-7. 2005
    ..These data show that functional 5-HT7 receptors are present in human microglial MC-3 cells, suggesting that they are involved in neuroinflammatory processes...
  62. ncbi Reduced social interaction following 3,4-methylenedioxymethamphetamine is not associated with enhanced 5-HT 2C receptor responsivity
    E J Bull
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Neuropharmacology 44:439-48. 2003
    ..These data suggest that the MDMA-induced reduction in social interaction is not mediated via alteration of 5-HT(2C) receptor function...
  63. ncbi Influence of postweaning social isolation in the rat on brain development, conditioned behavior, and neurotransmission
    M D S Lapiz
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UN, United Kingdom
    Neurosci Behav Physiol 33:13-29. 2003
    ..A greater understanding of the processes that underlie these changes should improve our knowledge of how environmental events may alter brain development and function, and play a role in the development of neuropsychiatric disorders...
  64. pmc In vivo interaction between serotonin and galanin receptors types 1 and 2 in the dorsal raphe: implication for limbic seizures
    Andrey M Mazarati
    Department of Pediatrics, Division of Pediatric Neurology, D Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Neurochem 95:1495-503. 2005
    ....
  65. ncbi Hyperpolarization-activated current I(h) in nucleus of solitary tract neurons: regional difference in serotonergic modulation
    Yuki Iwahori
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
    Jpn J Pharmacol 88:459-62. 2002
    ..The effect of 5-HT was blocked by NAN-190, a 5-HT1A receptor antagonist. Thus, 5-HT1A receptors may regulate I(h) channel activity in caudal and medial NTS neurons...
  66. ncbi Different regulation of rat 5-HT(2A) and rat 5-HT(2C) receptors in NIH 3T3 cells upon exposure to 5-HT and pipamperone
    D V Oekelen
    Department of Biochemical Pharmacology, Janssen Pharmaceutica, Janssen Research Foundation, Turnhoutseweg 30, B-2340 Beerse, Belgium
    Eur J Pharmacol 425:21-32. 2001
    ..The uncoupled receptor does not bind 5-HT in the nanomolar range but retains its antagonist binding properties. Paradoxical antagonist-induced desensitisation of rat 5-HT(2A) receptors has also been observed in vivo...
  67. ncbi Mechanisms of serotonergic agents for treatment of gastrointestinal motility and functional bowel disorders
    S Kindt
    Center of Gastroenterological Research, Catholic University Leuven, Leuven, Belgium
    Neurogastroenterol Motil 19:32-9. 2007
    ....
  68. ncbi Pharmacogenomics and serotonergic agents: research observations and potential clinical practice implications
    M Camilleri
    CENTER Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 19:40-5. 2007
    ....
  69. ncbi 3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions
    M G Bankson
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555-1031, USA
    J Pharmacol Exp Ther 297:846-52. 2001
    ....
  70. ncbi Effects of repeated systemic administration of d-Fenfluramine on serotonin and glutamate release in rat ventral hippocampus: comparison with methamphetamine using in vivo microdialysis
    C Rocher
    Laboratoire de Neuropharmacologie UPRES EAD MENRT, , , , , France
    Naunyn Schmiedebergs Arch Pharmacol 363:422-8. 2001
    ..These data highlight marked in vivo differences between METH and d-Fenfluramine in their effects on extracellular levels of 5-HT and Glu in the rat ventral hippocampus following their repeated systemic administration...
  71. ncbi Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of L-5-hydroxytryptophan
    X Wang
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, P O Box 5180, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroscience 148:212-20. 2007
    ..Next, we treated rats with the 5-HT precursor, l-5-hydroxytryptophan (5-HTP), in an attempt to restore MDMA-induced depletions of 5-HT...
  72. ncbi In vivo binding properties of [carbonyl-11C]WAY-100635: effect of endogenous serotonin
    J Maeda
    CREST, Japan Science and Technology Corporation (JST, Chiba, Japan
    Synapse 40:122-9. 2001
    ..These results indicated that the in vivo binding of [carbonyl-(11)C]WAY-100635 in the hippocampus and cerebral cortex mainly reflects postsynaptic 5-HT(1A) receptor binding, and that this binding is not sensitive to endogenous 5-HT...
  73. pmc Multiple conductances are modulated by 5-HT receptor subtypes in rat subthalamic nucleus neurons
    K Z Shen
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Neuroscience 148:996-1003. 2007
    ..But in neurons in which 5-HT evoked outward current, 5-HT slowed NMDA-dependent burst firing. We conclude that 5-HT receptor subtypes can differentially regulate firing pattern by modulating multiple conductances in STN neurons...
  74. ncbi Acceleration of serotonin transporter transport-associated current by 3,4-methylenedioxymethamphetamine (MDMA) under acidic conditions
    Yosuke Yamauchi
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Neurosci Lett 428:72-6. 2007
    ..4, suggesting that the affinities to SERT binding sites are not influenced. These results suggest that the effect of MDMA on SERT is enhanced by acidic conditions...
  75. ncbi Ascorbic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5-HT
    M Shankaran
    College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267-0004, USA
    Synapse 40:55-64. 2001
    ....
  76. ncbi The role of 5-HT on the cardiovascular and renal systems and the clinical potential of 5-HT modulation
    Sheila A Doggrell
    School of Biomedical Sciences, University of Queensland, QLD 4072, Australia
    Expert Opin Investig Drugs 12:805-23. 2003
    ..In hypertension, agonists at the 5-HT(7) and antagonists at the 5-HT(2B) may reduce blood pressure, and in diabetes, sarpogrelate may protect against nephropathy...
  77. ncbi Neuropsychotoxicity of abused drugs: effects of serotonin receptor ligands on methamphetamine- and cocaine-induced behavioral sensitization in mice
    Yukio Ago
    Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan
    J Pharmacol Sci 106:15-21. 2008
    ....
  78. ncbi Effects of dietary sucrose on hippocampal serotonin release: a microdialysis study in the freely-moving rat
    I Smolders
    Department of Pharmaceutical Chemistry and Drug Analysis, Pharmaceutical Institute, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    Br J Nutr 86:151-5. 2001
    ..A practical implication of the present findings is that dietary sucrose may bias the results of studies investigating brain serotoninergic mechanisms and the effects of (anorectic) drugs interacting with 5HT systems in the hippocampus...
  79. ncbi Serotonin mediates rapid changes of striatal glucose and lactate metabolism after systemic 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") administration in awake rats
    Jan Bert Gramsbergen
    Anatomy and Neurobiology, Institute of Medical Biology, University of Southern Denmark, Winsløwparken 21, DK 5000 Odense C, Denmark
    Neurochem Int 51:8-15. 2007
    ..1 degrees C) following systemic MDMA treatment were entirely blocked in p-chlorophenylalanine pre-treated rats, indicating that these effects are mediated by endogenous serotonin...
  80. pmc Tolerance to 3,4-methylenedioxymethamphetamine in rats exposed to single high-dose binges
    M H Baumann
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, 333 Cassell Drive, Suite 4500, Baltimore, MD 21224, USA
    Neuroscience 152:773-84. 2008
    ..Our results suggest that MDMA tolerance in humans may reflect 5-HT deficits which could contribute to further dose escalation...
  81. ncbi Partial denervation of the locus coeruleus projections by treatment with the selective neurotoxin DSP-4 potentiates the long-term effect of parachloroamphetamine on 5-hydroxytryptamine metabolism in the rat
    Marika Eller
    Department of Psychology, Centre of Behavioural and Health Sciences, University of Tartu, 50410, Estonia
    Neurosci Lett 322:53-6. 2002
    ..Conclusively, after limited alterations in the LC projections, there is an enhanced sensitivity of 5-HT-ergic nerve terminals to PCA...
  82. ncbi Effect of endogenous serotonin on the binding of the 5-hT1A PET ligand 18F-MPPF in the rat hippocampus: kinetic beta measurements combined with microdialysis
    Luc Zimmer
    CERMEP Biomedical Cyclotron, Lyon, France
    J Neurochem 80:278-86. 2002
    ..After modelization, 18F-MPPF binding could constitute an interesting radiotracer for positron emission tomography in evaluating the serotonin endogenous levels in limbic areas of the human brain...
  83. ncbi Characterization of serotonin(4) receptors in adrenocortical aldosterone-producing adenomas: in vivo and in vitro studies
    Herve Lefebvre
    European Institute for Peptide Research IFRMP 23, Department of Endocrinology, INSERM, U 413, Centre Hospitalo Universitaire de Rouen, 76031 Rouen, France
    J Clin Endocrinol Metab 87:1211-6. 2002
    ..Our results also suggest that 5-HT, which can be locally released by intratumoral mast cells, may play a role in the pathophysiology of these tumors...
  84. ncbi Endogenous serotonin excites striatal cholinergic interneurons via the activation of 5-HT 2C, 5-HT6, and 5-HT7 serotonin receptors: implications for extrapyramidal side effects of serotonin reuptake inhibitors
    Paola Bonsi
    Fondazione Santa Lucia I R C C S, European Brain Research Institute, Rome, Italy
    Neuropsychopharmacology 32:1840-54. 2007
    ..These results suggest that 5-HT released by serotonergic fibers originating in the raphe nuclei has a potent excitatory effect on striatal cholinergic interneurons...
  85. ncbi Changes in the brain serotonin satiety system in transgenic rats lacking brain angiotensinogen
    J P Voigt
    University of Nottingham, School of Veterinary Medicine and Science, Sutton Bonington Campus, Sutton Bonington, Leicestershire, UK
    J Neuroendocrinol 20:182-7. 2008
    ..Taken together, these findings suggest that the transgenic effect on the brain 5-HT system is paralleled by functional changes of the serotonergic feeding system...
  86. pmc DARPP-32 mediates serotonergic neurotransmission in the forebrain
    Per Svenningsson
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:3188-93. 2002
    ..Our data indicate that DARPP-32 is essential not only for dopaminergic but also for serotonergic neurotransmission...
  87. ncbi Reduced serotonin release and serotonin uptake sites in the rat nucleus accumbens and striatum after prenatal cocaine exposure
    Qing Shan Yan
    Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine, Peoria, IL 61656, USA
    Brain Res 929:59-69. 2002
    ....
  88. ncbi Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines
    Tao Xie
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 31:2639-51. 2006
    ....
  89. ncbi Moclobemide: therapeutic use and clinical studies
    Udo Bonnet
    Department of Psychiatry and Psychotherapy, University of Essen, Germany
    CNS Drug Rev 9:97-140. 2003
    ..There is no evidence that moclobemide would increase body weight or produce seizures. Some preclinical data suggest that moclobemide may have anticonvulsant property...
  90. ncbi Efficacy of mirtazapine in obstructive sleep apnea syndrome
    David W Carley
    Center for Narcolepsy, Sleep and Health Research, Department of Medical Surgical Nursing, University of Illinois, M C 719, Room 910, 40 South Wood Street, Chicago, IL 60612, USA
    Sleep 30:35-41. 2007
    ..We sought to determine whether mirtazapine, a mixed 5-HT2/5-HT3 antagonist that also promotes serotonin release in the brain would effectively reduce AHI during both NREM and REM sleep in patients with OSA...
  91. ncbi Current concepts in the pharmacological management of obesity
    P J Carek
    Medical University of South Carolina, Charleston 29425, USA
    Drugs 57:883-904. 1999
    ..Therefore, diet and exercise should be the focus of any weight loss programme. There is a continued need for safe and effective pharmacotherapeutic agents for the treatment of obesity...
  92. ncbi Interaction of serotonergic excitatory drive to hypoglossal motoneurons with carbachol-induced, REM sleep-like atonia
    L Kubin
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA
    Sleep 19:187-95. 1996
    ..The study also demonstrates that other, non-serotonergic, mechanisms also contribute to the carbachol-induced suppression...
  93. pmc The pharmacological profile of ovalbumin-induced paw oedema in rats
    R F G Feitosa
    Institute of Biomedicine, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, Brazil
    Mediators Inflamm 11:155-63. 2002
    ..These data indicate that allergic oedema is more sensitive to anti-serotonin drugs, mainly anti-5-HT2, suggesting that the principal mediator of this inflammatory response is serotonin...
  94. ncbi S-100beta protects cultured neurons against glutamate- and staurosporine-induced damage and is involved in the antiapoptotic action of the 5 HT(1A)-receptor agonist, Bay x 3702
    B Ahlemeyer
    Institut fur Pharmakologie und Toxikologie, Fachbereich Pharmazie der Philipps Universität, Marburg, Ketzerbach 63, Marburg, Germany
    Brain Res 858:121-8. 2000
    ..Furthermore, S-100beta mediated partially the protective effect of the 5-HT(1A) receptor agonist, Bay x 3702, against staurosporine-induced apoptosis in mixed neuronal/glial cultures from neonatal rat hippocampus...
  95. ncbi Cerebral metabolic effects of serotonin drugs and neurotoxins
    U Freo
    Clinica delle Malattie Nervose e Mentali, Padova
    Life Sci 59:877-91. 1996
    ..b>Serotonin agents produced rCMRglc patterns different and more specific that one would predict from binding studies...
  96. ncbi Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity
    P K Gillman
    Pioneer Valley Private Hospital, Mackay, Queensland, Australia
    Br J Anaesth 95:434-41. 2005
    ..Morphine, codeine, oxycodone and buprenorphine are known not to be SRIs, and do not precipitate serotonin toxicity with MAOIs...
  97. ncbi Clinically significant drug interactions with antidepressants in the elderly
    Edoardo Spina
    Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Policlinico Universitario, Messina, Italy
    Drugs Aging 19:299-320. 2002
    ..Among other newer antidepressants, nefazodone is a potent inhibitor of CYP3A4 and its combination with substrates of this isoform should be avoided...
  98. ncbi Serotonin agonists and antagonists in obstructive sleep apnea: therapeutic potential
    Sigrid C Veasey
    Department of Medicine, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    Am J Respir Med 2:21-9. 2003
    ..However, with continued effort to elucidate the pharmacology of neurochemical control of state-dependent changes in respiratory control, the availability of pharmacological therapy for this disorder is not too far away...
  99. doi [Frontotemporal dementia: a review]
    V Chauvire
    Clinique des maladies mentales et de l Encéphale, Centre Hospitalier Sainte Anne, 100, rue de la Santé, 75674 Paris Cedex 14, France
    Encephale 33:933-40. 2007
    ....
  100. ncbi Activation of hypothalamic serotonin receptors reduced intake of dietary fat and protein but not carbohydrate
    B K Smith
    Obesity, Diabetes and Metabolism Section, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Am J Physiol 277:R802-11. 1999
    ..These results demonstrate a selective effect of exogenous serotonergic drugs in the hypothalamus to reduce fat rather than carbohydrate intake and suggest that higher baseline fat intake enhances responsivity to serotonergic drugs...
  101. ncbi Use of sibutramine and other noradrenergic and serotonergic drugs in the management of obesity
    D H Ryan
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Endocrine 13:193-9. 2000
    ....

Research Grants62

  1. Serotonergic Contribution to Adolescent Risk Taking
    ANDREW EMMETT ARRANT; Fiscal Year: 2012
    ....
  2. Serotonin Club Meeting 2010
    JULIE GORTON HENSLER; Fiscal Year: 2010
    ....
  3. ELECTROANALYSIS OF NEUROTRANSMITTERS AND MODULATORS
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
    ..The information they provide will enable a subsecond view into their concentration fluctuations of these two neurotransmitter as they regulate specific behaviors. ..
  4. Exploring the role of the central amygdala in vocalization
    IAN CHRISTOPHER HALL; Fiscal Year: 2013
    ....
  5. Neuromodulation of cortical circuits in health and disease
    Allan T Gulledge; Fiscal Year: 2013
    ....
  6. Methylphenidate, Serotonin and Dopamine Interactions
    Sara R Jones; Fiscal Year: 2013
    ..p. MPH treatment in mice, 2) Sites of 5-HT action, using dual probe microdialysis in mice 3) MPH self-administration in rats 4) 5-HT alterations in response to MPH self-administration. ..
  7. Cerebellar Neuromodulation
    Kamran Khodakhah; Fiscal Year: 2013
    ..The goal of this proposal is to delineate the effects of serotonergic drugs on cerebellar Purkinje cells. ..
  8. Neurobiological Bases of Placebo Response in Major Depressive Disorder
    Cristina Cusin; Fiscal Year: 2013
    ..The understanding of the neurobiological bases of placebo effect, and how to modulate it, would potentially lead to the development of new treatments for depression and profoundly modify the conduct of clinical trials. ..
  9. Serotonin Club IUPHAR Satellite Meeting
    Mark Geyer; Fiscal Year: 2006
    ..Hence, helping neuroscientists-in-training attend the meeting will have a positive influence on trainees and a lasting impact on the field. [unreadable] [unreadable] [unreadable]..
  10. GENETIC AND BIOCHEMICAL DISSECTION OF PROLACTIN ACTIONS
    NELSON HORSEMAN; Fiscal Year: 2006
    ..These models will allow us to examine the role of mammary-expressed TPH in development and physiology in animals that have interruptions in their autocrine/paracrine 5-HT exposure. ..
  11. SELECTIVE SEROTONERGIC AGENTS
    RICHARD GLENNON; Fiscal Year: 2004
    ..Radioligand binding and functional assays will be conducted. The 5-HT1F ligand is not selective; we propose to explore its structure-activity relationships and functional activity in an attempt to develop a 5-HT1F-selective ligand. ..
  12. Exercise, Serotonin and Anxiety
    SAYAMWONG EMWILL HAMMACK; Fiscal Year: 2010
    ..Understanding these mechanisms will provide critical insight for both the etiology and treatment of anxiety disorders. ..
  13. NEUROCHEMICAL EFFECTS OF PRENATAL COCAINE IN RAT STRIATA
    Denise Jackson; Fiscal Year: 2002
    ..Third, the results of the studies cited in this proposal may relate to issues involving propensity of children of cocaine-addicted mothers to abuse cocaine and to sex differences in cocaine sensitivity. ..
  14. Bioreactor Organ Cultures of Serotonergic Valvulopathies
    KATHRYN GRANDE ALLEN; Fiscal Year: 2007
    ..In the future, similar methods can be used to screen potentially damaging drugs and to understand other valve diseases - both essential to public health. [unreadable] [unreadable]..
  15. SEROTONERGIC MODULATION OF ETHANOL'S MOTIVATIONAL EFFECT
    FRED RISINGER; Fiscal Year: 1999
    ..These experiments will provide important new information on the mechanism of ethanol's motivational effects which are often seen as critical for the development of alcoholism and alcohol abuse. ..
  16. SUBSTANCE DEPENDENT TEENS--IMPACT OF TREATING DEPRESSION
    Paula Riggs; Fiscal Year: 2004
    ....
  17. A Pharmacogenetic Study of Escitalopram in Autism
    Thomas Owley; Fiscal Year: 2006
    ..abstract_text> ..
  18. PSYCHOTHERAPY AND MEDICATION FOR BINGE EATING DISORDER
    Michael Devlin; Fiscal Year: 2001
    ..Treatment will take place over a period of five months, and patients will be followed for two years after treatment. ..
  19. Cannabinoid Antagonist Influences on Ingestive Behavior
    JAMES KOCH; Fiscal Year: 2003
    ..Each rat receives all doses of a specific compound and serves as its own experimental control, thus creating a basic within-subjects design which reveals dose-dependent effects on behavior, in this case ingestion. ..
  20. The role of the M-current in the anorectic effects of estrogen and serotonin.
    TROY ROEPKE; Fiscal Year: 2007
    ..The mechanism through which peripheral and central signals control food intake must be examined to develop new strategies and therapies for one of the most serious health issues facing us today. [unreadable] [unreadable] [unreadable]..
  21. SITE-SELECTIVE SEROTONERGIC AGENTS
    RICHARD GLENNON; Fiscal Year: 1990
    ..g. 5-HT1D, 5-HT3) or have not yet been identified in human brain (5-HT1B, 5-HT3); studies similar to those described above can ultimately be used to identify/study agents selective for these sites...
  22. HUMAN BEHAVIORAL PHARMACOLOGY OF DRUG ABUSE
    George Bigelow; Fiscal Year: 2002
    ..The cocaine dependence clinical trials will evaluate the efficacy of the serotonergic agents tryptophan and fluoxetine in the context of an incentive-based behavior therapy program. ..
  23. Human Tissue Cell-Based Toxicity by Flow Cytometry
    John Ransom; Fiscal Year: 2003
    ..abstract_text> ..
  24. SYNAPTIC ORGANIZATION OF THE BASOLATERAL AMYGDALA
    ALEXANDER MCDONALD; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  25. SEROTONERGIC MECHANISMS IN ALCOHOL DEPENDENCE
    SUBHASH PANDEY; Fiscal Year: 2000
    ..g., anxiety. ..
  26. Austin 5HT Candidate Gene Discovery with C Elegans
    J Jay Gargus; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  27. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  28. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  29. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  30. DO GENES & BRAIN ACTIVITY PREDICT ALCOHOL RISK?
    Nassima Ait Daoud; Fiscal Year: 2005
    ....
  31. Sleep Apnea: Upper Airway Nerve Injury
    Sigrid Veasey; Fiscal Year: 2009
    ..Collectively, the proposed studies will unveil important mechanisms of neuronal injury in obstructive sleep apnea and should reveal diabetes is a risk factor for this neural injury in sleep apnea. ..
  32. DEVELOPMENTAL EFFECTS OF METHLENEDIOXYMETHAMPHETAMINE
    Charles Vorhees; Fiscal Year: 2002
    ..Such data will help identify risks associated with the prenatal use of MDMA on brain and cognitive development. ..
  33. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE-LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 2009
    ..The number of prenatally MA exposed children continues to grow. Our goal is to develop models of early MA exposure that permit an understanding of the long-term consequences on brain development and cognition. ..
  34. Effects of Neonatal MDMA on Brain and Behavior
    Charles V Vorhees; Fiscal Year: 2010
    ....
  35. Matching 5-HT Genotypes to Serotonergic Medications for Alcoholism
    GEORGE ANTHONY KENNA; Fiscal Year: 2010
    ....
  36. NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBS
    Lin Chang; Fiscal Year: 2010
    ..abstract_text> ..
  37. NEURAL MECHANISMS RESETTING THE AGED CIRCADIAN PACEMAKER
    Marilyn J Duncan; Fiscal Year: 2010
    ....
  38. Effects of Chronic THC in Adolescence
    Peter J Winsauer; Fiscal Year: 2010
    ..Together, data from these experiments will demonstrate how drug abuse and hormonal status during adolescence may permanently alter brain function and the liability of subsequent abuse of A9-THC. ..
  39. Genetic Factors in Human MDMA Toxicity: A PET Study
    Ronald Cowan; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  40. MR Analysis of Persistent CNS Damage in Human MDMA Users
    Ronald Cowan; Fiscal Year: 2006
    ..abstract_text> ..
  41. High-Field Functional MRI of Human Euphoria
    Ronald Cowan; Fiscal Year: 2003
    ..Eventually, we believe that a better understanding of the brain structures that allow us to get high, and become addicted, will lead to improved awareness and treatment for substance abuse. ..
  42. BRAIN SEROTONIN TRANSPORTER IN ECSTASY AND MDA USERS
    Stephen Kish; Fiscal Year: 2007
    ..More broadly, our data will help define the contribution of different neuroanatomical components of the brain serotonin system to human behavior. ..
  43. SERT polymorphisms and human cortical 5-HT2A receptors
    Ronald Cowan; Fiscal Year: 2007
    ..Because the rate of depression is greater in females than males, and because regulation of the 5-HT2A receptor is influenced by estrogen, we have chosen to study the effects of having SS or L-A L-A genotype in female subjects. ..
  44. DIFFERENTIAL VULNERABILITY TO MORBIDITIES OF SLEEP APNEA
    Sigrid Veasey; Fiscal Year: 2003
    ..Therefore, this work provides an essential foundation for determining gene function in the susceptibility of sleepiness, impaired cognation and behavioral responses caused by obstructive sleep apnea. (End of Abstract.) ..
  45. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  46. PLATELET ACTIVATING FACTOR SIGNALING IN LIVER
    Rory Fisher; Fiscal Year: 2002
    ..The proposed studies will provide novel insights into the molecular basis of action of PAF and should have broad implications in understanding PAF signaling in liver and other tissues. ..
  47. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  48. TRAINING IN FUNCTIONAL IMAGING AND ALCOHOL WITHDRAWAL
    DONALD MYRICK; Fiscal Year: 2004
    ....
  49. Crack & Health Service Use--A Natural History Approach
    Russel Falck; Fiscal Year: 2005
    ....
  50. Molecular Analysis and Role of RGS6 as a Novel Growth Suppressor
    Rory A Fisher; Fiscal Year: 2010
    ..This work will determine how RGS6 works and will determine the basis for loss of RGS6 expression in human cancers. These studies could contribute to novel approaches in cancer therapy. ..
  51. MDMA Neurotoxicity in Humans: Occurence & Consequences
    George Ricaurte; Fiscal Year: 2006
    ....
  52. PET Imaging MDMA Neurotoxicity
    Una McCann; Fiscal Year: 2006
    ..g., dementia, Parkinsonism, depression/anxiety). In addition, the proposed 18FDG studies will address the question of if MDMA exposure leads to altered brain function at the most fundamental level, glucose utilization. ..
  53. Zonisamide for Weight Reduction in Obese Adults
    Kishore Gadde; Fiscal Year: 2009
    ..We will also systematically assess whether weight loss achieved with zonisamide treatment can reduce metabolic and cardiovascular risk factors. ..
  54. Norepinephrine and Impulsivity
    Alan Swann; Fiscal Year: 2009
    ..The results of these experiments may suggest means for monitoring risk for impulsive behavior and for a rational treatment schema for impulsivity. ..
  55. New PET radioligand for the serotonin transporter
    Yiyun Huang; Fiscal Year: 2007
    ..Introduction of [18F]AFM would constitute the first PET tracer for the SERT that can be prepared in a central facility and distributed to various sites for clinical imaging purposes. ..
  56. Tryptophan Metabolism, Genes, and Major Depression
    David Steffens; Fiscal Year: 2007
    ..Results from this study will help inform future treatment studies using genetics and metabolomic technology. [unreadable] [unreadable] [unreadable]..
  57. Distress, Fish Oil, Inflammation, and Heart Disease
    Matthew Muldoon; Fiscal Year: 2006
    ..Results of the study could redirect current conceptualizations of the relationship between psychological factors and CHD risk, and lead to randomized clinical trials testing new interventions. ..
  58. Development of the enteric nervous system: Cells & genes
    Michael Gershon; Fiscal Year: 2006
    ..The invited speakers include all of the leading researchers in the field, including Professor Nicole Le Douarin. We also anticipate that many post-graduate students and post-doctoral fellows will also attend. [unreadable] [unreadable]..
  59. Trigeminal Mechanisms of Oral Irritation
    Earl Carstens; Fiscal Year: 2009
    ..In a corresponding animal study, we will determine if responses of neurons in the n. tractus solitarius (NTS), a taste relay, are reduced by intraoral capsaicin ..
  60. NEURAL CONTROL OF THE GALLBLADDER
    Gary M Mawe; Fiscal Year: 2010
    ....
  61. DEVELOPMENTAL PLASTICITY IN VENTILATORY CONTROL
    Gordon Mitchell; Fiscal Year: 2001
    ..Further understanding of mechanism(s) that underlie developmental plasticity with its associated functional impairments may provide the rationale for therapeutic intervention, thereby enhancing functional recovery. ..