serotonin uptake inhibitors

Summary

Summary: Compounds that specifically inhibit the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. These agents have been used in treatment of depression, panic disorder, obsessive-compulsive behavior, and alcoholism, as analgesics, and to treat obesity and bulimia. Many of the ADRENERGIC UPTAKE INHIBITORS also inhibit serotonin uptake; they are not included here.

Top Publications

  1. ncbi The antidepressant fluoxetine restores plasticity in the adult visual cortex
    José Fernando Maya Vetencourt
    Scuola Normale Superiore, Piazza dei Cavalieri, I 56100 Pisa, Italy
    Science 320:385-8. 2008
  2. pmc Gastro-intestinal haemorrhage risks of selective serotonin receptor antagonist therapy: a new look
    Lucie Opatrny
    Division of Clinical Epidemiology, McGill University Health Center, McGill University, Montreal, Canada
    Br J Clin Pharmacol 66:76-81. 2008
  3. ncbi Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses
    Tim F Oberlander
    Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Epigenetics 3:97-106. 2008
  4. ncbi Risk of upper gastrointestinal tract bleeding associated with selective serotonin reuptake inhibitors and venlafaxine therapy: interaction with nonsteroidal anti-inflammatory drugs and effect of acid-suppressing agents
    Francisco J de Abajo
    Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Agency for Medicines and Healthcare Products, Campezo 1, Madrid 28022, Spain
    Arch Gen Psychiatry 65:795-803. 2008
  5. pmc Paradoxical anxiogenic response of juvenile mice to fluoxetine
    Ji Eun Oh
    Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Neuropsychopharmacology 34:2197-207. 2009
  6. ncbi Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Exchange Park Express, American General Tower, 6363 Forest Park Rd, Suite 1300, Dallas, TX 75390 9119, USA
    Am J Psychiatry 163:28-40. 2006
  7. ncbi Pain reactivity in 2-month-old infants after prenatal and postnatal serotonin reuptake inhibitor medication exposure
    Tim F Oberlander
    Department of Pediatrics, Biobehavioral Research Unit, Centre for Community Child Health Research, Room L408, 4480 Oak St, Vancouver, BC, Canada
    Pediatrics 115:411-25. 2005
  8. ncbi miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants
    Anne Baudry
    Cellules Souches, Signalisation et Prions, INSERM U747, Universite Paris Descartes, 75006 Paris, France
    Science 329:1537-41. 2010
  9. ncbi Delivery outcome after maternal use of antidepressant drugs in pregnancy: an update using Swedish data
    M Reis
    Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linkoping, Sweden
    Psychol Med 40:1723-33. 2010
  10. pmc Fluoxetine targets early progenitor cells in the adult brain
    Juan M Encinas
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 103:8233-8. 2006

Detail Information

Publications292 found, 100 shown here

  1. ncbi The antidepressant fluoxetine restores plasticity in the adult visual cortex
    José Fernando Maya Vetencourt
    Scuola Normale Superiore, Piazza dei Cavalieri, I 56100 Pisa, Italy
    Science 320:385-8. 2008
    ..Our results suggest a potential clinical application for fluoxetine in amblyopia as well as new mechanisms for the therapeutic effects of antidepressants and for the pathophysiology of mood disorders...
  2. pmc Gastro-intestinal haemorrhage risks of selective serotonin receptor antagonist therapy: a new look
    Lucie Opatrny
    Division of Clinical Epidemiology, McGill University Health Center, McGill University, Montreal, Canada
    Br J Clin Pharmacol 66:76-81. 2008
    ....
  3. ncbi Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses
    Tim F Oberlander
    Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Epigenetics 3:97-106. 2008
    ....
  4. ncbi Risk of upper gastrointestinal tract bleeding associated with selective serotonin reuptake inhibitors and venlafaxine therapy: interaction with nonsteroidal anti-inflammatory drugs and effect of acid-suppressing agents
    Francisco J de Abajo
    Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Agency for Medicines and Healthcare Products, Campezo 1, Madrid 28022, Spain
    Arch Gen Psychiatry 65:795-803. 2008
    ..The wide use of these drugs makes such potential risk a public health concern, and identification of factors that may increase or minimize such risk is necessary...
  5. pmc Paradoxical anxiogenic response of juvenile mice to fluoxetine
    Ji Eun Oh
    Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Neuropsychopharmacology 34:2197-207. 2009
    ....
  6. ncbi Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Exchange Park Express, American General Tower, 6363 Forest Park Rd, Suite 1300, Dallas, TX 75390 9119, USA
    Am J Psychiatry 163:28-40. 2006
    ....
  7. ncbi Pain reactivity in 2-month-old infants after prenatal and postnatal serotonin reuptake inhibitor medication exposure
    Tim F Oberlander
    Department of Pediatrics, Biobehavioral Research Unit, Centre for Community Child Health Research, Room L408, 4480 Oak St, Vancouver, BC, Canada
    Pediatrics 115:411-25. 2005
    ..Based on previous findings showing reduced pain responses in newborns after prenatal exposure, we hypothesized that altered pain reactivity would also be found at 2 months of age...
  8. ncbi miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants
    Anne Baudry
    Cellules Souches, Signalisation et Prions, INSERM U747, Universite Paris Descartes, 75006 Paris, France
    Science 329:1537-41. 2010
    ..Based on pharmacological and behavioral data, we propose that miR-16 contributes to the therapeutic action of SSRI antidepressants in monoaminergic neurons...
  9. ncbi Delivery outcome after maternal use of antidepressant drugs in pregnancy: an update using Swedish data
    M Reis
    Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linkoping, Sweden
    Psychol Med 40:1723-33. 2010
    ..Concerns have been expressed about possible adverse effects of the use of antidepressant medication during pregnancy, including risk for neonatal pathology and the presence of congenital malformations...
  10. pmc Fluoxetine targets early progenitor cells in the adult brain
    Juan M Encinas
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 103:8233-8. 2006
    ..This finding defines a cellular target for antidepressant drug therapies...
  11. ncbi Increasing use of antidepressants in pregnancy
    William O Cooper
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232 2504, USA
    Am J Obstet Gynecol 196:544.e1-5. 2007
    ..The purpose of this study was to quantify the rate of exposures to antidepressants during pregnancy in a large cohort of women...
  12. ncbi Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) Randomized Trial
    Lisa F Berkman
    Harvard University, Boston, MA, USA
    JAMA 289:3106-16. 2003
    ..Depression and low perceived social support (LPSS) after myocardial infarction (MI) are associated with higher morbidity and mortality, but little is known about whether this excess risk can be reduced through treatment...
  13. ncbi High-speed imaging reveals neurophysiological links to behavior in an animal model of depression
    Raag D Airan
    Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
    Science 317:819-23. 2007
    ..Our results define a circuit-level neurophysiological endophenotype for affective behavior and suggest an approach to understanding circuit-level substrates underlying psychiatric disease symptoms...
  14. ncbi Sertraline increases extracellular levels not only of serotonin, but also of dopamine in the nucleus accumbens and striatum of rats
    Yuji Kitaichi
    Department of Molecular Stressphysiology, Max Planck Institute of Psychiatry, Munich, Germany
    Eur J Pharmacol 647:90-6. 2010
    ..These results suggest that neurochemical differences account for the differences in clinical antidepressant effects among SSRIs...
  15. ncbi Selective serotonin reuptake inhibitors in childhood depression: systematic review of published versus unpublished data
    Craig J Whittington
    Centre for Outcomes Research and Effectiveness, Subdepartment of Clinical Health Psychology, University College London, 1 19 Torrington Place, London WC1E 7HB, UK
    Lancet 363:1341-5. 2004
    ..Questions concerning the safety of selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression in children led us to compare and contrast published and unpublished data on the risks and benefits of these drugs...
  16. ncbi New perspectives on the neurodevelopmental effects of SSRIs
    Judith R Homberg
    Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands
    Trends Pharmacol Sci 31:60-5. 2010
    ..Here, we review the existing evidence on the long-term effects of developmental SSRI exposure...
  17. pmc Selective serotonin reuptake inhibitors in pregnancy and congenital malformations: population based cohort study
    Lars Henning Pedersen
    Department of Epidemiology, Institute of Public Health, Aarhus University, Bartolin Allé 2, DK 8000 Aarhus, Denmark
    BMJ 339:b3569. 2009
    ..To investigate any association between selective serotonin reuptake inhibitors (SSRIs) taken during pregnancy and congenital major malformations...
  18. ncbi Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice
    Mark S Ansorge
    Sackler Institute for Developmental Psychobiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Science 306:879-81. 2004
    ....
  19. ncbi Neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitor antidepressants and maternal depression using population-based linked health data
    Tim F Oberlander
    Department of Pediatrics, Human Early Learning Partnership, Faculty of Graduate Studies, University of British Columbia, Vancouver
    Arch Gen Psychiatry 63:898-906. 2006
    ..Prenatal exposure to selective serotonin reuptake inhibitor (SSRI) antidepressants and maternal depression both alter neonatal health, and distinguishing the effects of each influence remains challenging...
  20. pmc Sustained neurobehavioral effects of exposure to SSRI antidepressants during development: molecular to clinical evidence
    T F Oberlander
    Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
    Clin Pharmacol Ther 86:672-7. 2009
    ..In humans, sustained developmental outcomes remain largely unstudied, and distinguishing between the effects of prenatal SSRI exposure and the impact of maternal mental illness remains a key challenge...
  21. pmc LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake
    Zheng Zhou
    Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Science 317:1390-3. 2007
    ..Mutagenesis experiments on human SERT and DAT indicate that both the desipramine-binding site and its inhibition mechanism are probably conserved in the human neurotransmitter transporters...
  22. ncbi Genetic predictors of response to antidepressants in the GENDEP project
    Rudolf Uher
    MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King s College London, London, UK
    Pharmacogenomics J 9:225-33. 2009
    ..The single marker associations explained only a small proportion of variance in response to antidepressants, indicating a need for a multivariate approach to prediction...
  23. ncbi Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn
    Christina D Chambers
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92103, USA
    N Engl J Med 354:579-87. 2006
    ..We performed a case-control study to assess whether PPHN is associated with exposure to SSRIs during late pregnancy...
  24. ncbi Neonatal signs after late in utero exposure to serotonin reuptake inhibitors: literature review and implications for clinical applications
    Eydie L Moses-Kolko
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    JAMA 293:2372-83. 2005
    ..Integration of data about the neonatal behavioral syndrome into the management of pregnancy in women who take SRIs is a current challenge for physicians...
  25. ncbi Effects of exposure to selective serotonin reuptake inhibitors during pregnancy on serotonergic symptoms in newborns and cord blood monoamine and prolactin concentrations
    Kari Laine
    Department of Pharmacology and Clinical Pharmacology, University of Turku and Turku University Central Hospital, Turku, Finland
    Arch Gen Psychiatry 60:720-6. 2003
    ..We aimed to investigate the perinatal sequelae of infants exposed to SSRIs during their fetal life and the relationship of these symptoms to the cord blood monoamine and prolactin concentrations...
  26. ncbi The age-dependent effects of selective serotonin reuptake inhibitors in humans and rodents: A review
    J D A Olivier
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Dept of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21, 6525 GA Nijmegen, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 35:1400-8. 2011
    ..Given the overlap between human and rodent findings, rodents provide heuristic value in further research on the age-dependent effects of SSRIs...
  27. pmc Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics
    Y Ji
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA
    Clin Pharmacol Ther 89:97-104. 2011
    ..02) in DNA taken from these patients. These results highlight a possible role for glycine in SSRI response and illustrate the use of pharmacometabolomics to "inform" pharmacogenomics...
  28. ncbi Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9086, USA
    N Engl J Med 354:1231-42. 2006
    ..After unsuccessful treatment for depression with a selective serotonin-reuptake inhibitor (SSRI), it is not known whether switching to one antidepressant is more effective than switching to another...
  29. ncbi Effects of chronic fluoxetine in animal models of anxiety and depression
    Stephanie C Dulawa
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 29:1321-30. 2004
    ..In the forced swim test, 10 and 18 mg/kg/day increased swimming and reduced immobility. Here we present several novel effects of chronic, but not subchronic, antidepressant treatment...
  30. pmc Serotonin and depression: a disconnect between the advertisements and the scientific literature
    Jeffrey R Lacasse
    Florida State University College of Social Work, Tallahassee, Florida, United States of America
    PLoS Med 2:e392. 2005
  31. ncbi Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine
    Vered Stearns
    The Breast Cancer Program, Department of Medicine, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC, USA
    J Natl Cancer Inst 95:1758-64. 2003
    ..In a prospective clinical trial, we tested the effects of coadministration of tamoxifen and the SSRI paroxetine, an inhibitor of CYP2D6, on tamoxifen metabolism...
  32. ncbi First-trimester use of selective serotonin-reuptake inhibitors and the risk of birth defects
    Carol Louik
    Slone Epidemiology Center at Boston University, Boston, MA 02215, USA
    N Engl J Med 356:2675-83. 2007
    ..The risk of birth defects after antenatal exposure to selective serotonin-reuptake inhibitors (SSRIs) remains controversial...
  33. ncbi How psychotherapy changes the brain--the contribution of functional neuroimaging
    D E J Linden
    School of Psychology, University of Wales Bangor, Bangor, UK
    Mol Psychiatry 11:528-38. 2006
    ....
  34. pmc Effect of a single dose of citalopram on amygdala response to emotional faces
    Susannah E Murphy
    Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX
    Br J Psychiatry 194:535-40. 2009
    ..However, recent reports suggest they may have a much earlier therapeutic onset. A reduction in amygdala responsivity has been implicated in the therapeutic action of SSRIs...
  35. ncbi Antidepressant drug treatment modifies the neural processing of nonconscious threat cues
    Catherine J Harmer
    Department of Experimental Psychology, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 59:816-20. 2006
    ..Emotional disorders such as depression and anxiety have been associated with hyperactivity of the amygdala, but it is unknown whether antidepressant treatment directly affects amygdala responses to emotionally significant information...
  36. ncbi Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries
    Helle Kieler
    Centre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, T2, SE 171 76 Stockholm, Sweden
    BMJ 344:d8012. 2012
    ..To assess whether maternal use of selective serotonin reuptake inhibitors (SSRIs) increases the risk of persistent pulmonary hypertension in the newborn, and whether such an effect might differ between specific SSRIs...
  37. ncbi Use of selective serotonin-reuptake inhibitors in pregnancy and the risk of birth defects
    Sura Alwan
    Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
    N Engl J Med 356:2684-92. 2007
    ..Information regarding the safety of selective serotonin-reuptake inhibitors (SSRIs) in human pregnancy is sparse. Concern has been raised about the risk of congenital heart defects associated with the use of SSRIs in pregnancy...
  38. ncbi Citalopram improves dexterity in chronic stroke patients
    Simone Zittel
    Department of Neurology, University Medical Center Eppendorf, Hamburg, Germany
    Neurorehabil Neural Repair 22:311-4. 2008
    ..A majority of stroke patients have persisting motor deficits despite ongoing physiotherapy. Therefore, additional treatment options are desirable...
  39. pmc Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter
    Jacob Andersen
    Department of Medicinal Chemistry, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Biol Chem 285:2051-63. 2010
    ..The model defines the molecular determinants for (S)-citalopram binding to hSERT and demonstrates that the antidepressant binding site overlaps with the substrate binding site...
  40. ncbi Waterborne fluoxetine disrupts the reproductive axis in sexually mature male goldfish, Carassius auratus
    Jan A Mennigen
    Centre for Advances Research in Environmental Genomics, Department of Biology, University of Ottawa, Ontario, Canada
    Aquat Toxicol 100:354-64. 2010
    ..This study demonstrates that FLX disrupts reproductive physiology of male fish at environmentally relevant concentrations, and potential mechanisms are discussed...
  41. ncbi Neuronal effects of acute citalopram detected by pharmacoMRI
    S McKie
    Neuroscience and Psychiatry Unit, The University of Manchester, Manchester, UK
    Psychopharmacology (Berl) 180:680-6. 2005
    ..Serotonin (5-hydroxytryptamine, 5-HT) is implicated in the aetiology and treatment of a variety of psychiatric disorders. A limitation of research has been the necessity to use indirect measures of 5-HT function...
  42. ncbi Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: a population-based cohort study
    Susanne Oksbjerg Dalton
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Arch Intern Med 163:59-64. 2003
    ..Selective serotonin reuptake inhibitors (SSRIs) have been suspected of increasing the risk of bleeding. We examined the risk of upper gastrointestinal tract (GI) bleeding with use of antidepressant medication...
  43. pmc Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry
    Dorota Maciag
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA
    Neuropsychopharmacology 31:47-57. 2006
    ..It is not known whether this effect of SSRIs is paralleled in humans; however, these data suggest that in utero, exposure to SSRIs may have unforeseen long-term neurobehavioral consequences...
  44. ncbi Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain
    Tomi Rantamäki
    Neuroscience Center, University of Helsinki, PO Box 56, 00014 Helsinki, Finland
    Neuropsychopharmacology 32:2152-62. 2007
    ..In conclusion, our data suggest that rapid activation of the TrkB neurotrophin receptor and PLCgamma1 signaling is a common mechanism for all antidepressant drugs...
  45. ncbi Perinatal outcome following third trimester exposure to paroxetine
    Adriana Moldovan Costei
    The Motherisk Program, Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Arch Pediatr Adolesc Med 156:1129-32. 2002
    ..The drug readily crosses the human placenta. Although it does not appear to increase teratogenic risk, there have been case reports of neonatal withdrawal. Symptoms were described soon after birth and lasted up to 1 month...
  46. ncbi Pregnancy outcomes following exposure to serotonin reuptake inhibitors: a meta-analysis of clinical trials
    Roja Rahimi
    Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Reprod Toxicol 22:571-5. 2006
    ..Our results find that SRIs do not increase the risk of major, cardiovascular and minor malformations but do increase the risk of spontaneous abortion significantly...
  47. pmc Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures
    Zheng Zhou
    Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York, USA
    Nat Struct Mol Biol 16:652-7. 2009
    ..Thus, the specificity of SERT for SSRIs is dependent largely on interaction of the drug halogens with the protein's HBP...
  48. ncbi Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex
    Frank P Bymaster
    Neuroscience Research Division, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285 0510, USA
    Psychopharmacology (Berl) 160:353-61. 2002
    ..The effect of other SSRIs on monoamine concentrations in prefrontal cortex has not been thoroughly studied...
  49. pmc Imaging the serotonin transporter during major depressive disorder and antidepressant treatment
    Jeffrey H Meyer
    Neurochemical Imaging Program in Mood Disorders, PET Centre, Centre for Addiction and Mental Health, Toronto, Ont
    J Psychiatry Neurosci 32:86-102. 2007
    ..Implications of 5-HTT imaging findings for understanding major depressive disorder and antidepressant treatment will be discussed...
  50. ncbi Effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction
    C Barr Taylor
    Department of Psychiatry and Behavioral Sciences, Stanford Medical Center, Stanford University School of Medicine, Stanford, CA 94305 5722, USA
    Arch Gen Psychiatry 62:792-8. 2005
    ..Depression after myocardial infarction (MI) is associated with higher morbidity and mortality. Although antidepressants are effective in reducing depression, their use in patients with cardiovascular disease remains controversial...
  51. ncbi Antidepressants and the risk of suicidal behaviors
    Hershel Jick
    Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Mass 02421, USA
    JAMA 292:338-43. 2004
    ..The use of such drugs among teenagers has been of particular concern...
  52. ncbi Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression
    S H Kennedy
    Mood and Anxiety Disorders Program, Centre for Addiction and Mental Health, Clarke Site, 250 College St, Toronto, Ontario M5T 1R8, Canada
    Am J Psychiatry 158:899-905. 2001
    ..The aim of the present study was to assess the effects of successful paroxetine treatment on regional glucose metabolism in patients with major depression...
  53. ncbi Selective serotonin reuptake inhibitor exposure in utero and pregnancy outcomes
    Najaaraq Lund
    Bandim Health Project, INDEPTH Network, Apartado 861, Bissau, Guinea Bissau
    Arch Pediatr Adolesc Med 163:949-54. 2009
    ..To investigate the effect of intrauterine selective serotonin reuptake inhibitor (SSRI) exposure on pregnancy outcomes...
  54. ncbi Use of antidepressant medications during pregnancy: a multisite study
    Susan E Andrade
    Meyers Primary Care Institute, Worcester, MA 01605, USA
    Am J Obstet Gynecol 198:194.e1-5. 2008
    ..This study was undertaken to provide information on the prevalence of use of antidepressant drugs among pregnant women in the United States...
  55. ncbi Pharmacotherapy of posttraumatic stress disorder: a review of meta-analyses and treatment guidelines
    Dan J Stein
    Department of Psychiatry and Mental Health, University of Cape Town
    CNS Spectr 14:25-31. 2009
    ..Assessment of these meta-analyses and guidelines provides an opportunity to review the strengths and weaknesses of the evidence-base...
  56. pmc Behavioral destabilization induced by the selective serotonin reuptake inhibitor fluoxetine
    Katsunori Kobayashi
    Department of Pharmacology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Mol Brain 4:12. 2011
    ..Here we show that this unique form of neuronal plasticity is correlated with a distinct change in behavior of mice...
  57. ncbi Maternal selective serotonin reuptake inhibitor use during pregnancy and newborn neurobehavior
    Philip Sanford Zeskind
    Department of Pediatrics, Carolinas Medical Center, Charlotte, North Carolina 28232, USA
    Pediatrics 113:368-75. 2004
    ....
  58. ncbi Major depression and antidepressant treatment: impact on pregnancy and neonatal outcomes
    Katherine L Wisner
    Women s Behavioral HealthCARE and the Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 166:557-66. 2009
    ..This study examined whether 1) minor physical anomalies, 2) maternal weight gain and infant birth weight, 3) preterm birth, and 4) neonatal adaptation are affected by SSRI or depression exposure...
  59. ncbi Behavioral and biochemical responses of hybrid striped bass during and after fluoxetine exposure
    Kristen M Gaworecki
    Institute of Environmental Toxicology, Department of Biological Sciences, Clemson University, Pendleton, SC 29670, United States
    Aquat Toxicol 88:207-13. 2008
    ..These results suggest that sublethal exposure to fluoxetine decreases the ability of hybrid striped bass to capture prey and that serotonin can be used as a biomarker of exposure and effect...
  60. ncbi Pharmacokinetics of selective serotonin reuptake inhibitors
    C Hiemke
    Department of Psychiatry, University of Mainz, Germany
    Pharmacol Ther 85:11-28. 2000
    ....
  61. ncbi Evidence that increased 5-HT release evokes region-specific effects on blood-oxygenation level-dependent functional magnetic resonance imaging responses in the rat brain
    M A Preece
    Department of Pharmacology, Mansfield Road, Oxford, UK
    Neuroscience 159:751-9. 2009
    ..These findings support the use of fMRI imaging methods as a non-invasive tool to study 5-HT function in animal models, with the potential for extension to clinical studies...
  62. pmc International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol
    Leanne M Williams
    BRAINnet Foundation, 71 Stephenson Street, Suite 400, San Francisco, CA, 94105, USA
    Trials 12:4. 2011
    ..The aim of iSPOT-D is to identify pretreatment measures that predict or moderate MDD treatment response or remission to escitalopram, sertraline or venlafaxine; and develop a model that incorporates multiple predictors and moderators...
  63. ncbi Anti-depressants and suicide
    Jens Ludwig
    University of Chicago, Chicago, IL 60637, United States
    J Health Econ 28:659-76. 2009
    ..We find an increase in SSRI sales of 1 pill per capita (12% of 2000 sales levels) reduces suicide by 5%...
  64. ncbi Influence of citalopram and environmental temperature on exercise-induced changes in BDNF
    Maaike Goekint
    Department of Human Physiology and Sports Medicine, Vrije Universiteit Brussel, Brussels, Belgium
    Neurosci Lett 494:150-4. 2011
    ..Therefore, we hypothesized that administration of a selective serotonin reuptake inhibitor could influence the exercise-induced increase in BDNF, and that peripheral BDNF will be higher when exercise is performed in the heat...
  65. pmc Newborn neurobehavioral patterns are differentially related to prenatal maternal major depressive disorder and serotonin reuptake inhibitor treatment
    Amy L Salisbury
    Department of Pediatrics, Brown Center for the Study of Children at Risk, Women and Infants Hospital of Rhode Island and the Department of Pediatrics, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02905, USA
    Depress Anxiety 28:1008-19. 2011
    ..This study examined potential effects of MDD with and without SRI treatment on newborn neurobehavior...
  66. ncbi Treatment of resistant human colon cancer xenografts by a fluoxetine-doxorubicin combination enhances therapeutic responses comparable to an aggressive bevacizumab regimen
    Mirit Argov
    Department of Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel
    Cancer Lett 274:118-25. 2009
    ..Collectively, our results suggest that combinations of fluoxetine with chemotherapeutic drugs (P-glycoprotein substrates) are worthy of further pursuit for moderate MDR in the clinic...
  67. ncbi Prenatal SSRI exposure alters neonatal corticosteroid binding globulin, infant cortisol levels, and emerging HPA function
    Jodi L Pawluski
    Early Human Experience Unit, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Psychoneuroendocrinology 37:1019-28. 2012
    ..To address this, prenatal exposure to SSRIs and maternal mood were examined in relation to neonatal and infant levels of cortisol and its binding protein, corticosteroid-binding globulin (CBG)...
  68. ncbi Antidepressant use and the risk of upper gastrointestinal bleeding in psychiatric patients: a nationwide cohort study in Taiwan
    Yen Chieh Lee
    Department of Family Medicine, Cathay General Hospital, Taipei, Taiwan
    J Clin Psychopharmacol 32:518-24. 2012
    ..01). Elderly patients and those with prior UGIB history were more susceptible to the harmful effects. Our findings suggest that the use of high-affinity serotonin reuptake inhibitors may increase the risk for UGIB in psychiatric patients...
  69. ncbi Antidepressant use in pregnancy and persistent pulmonary hypertension of the newborn (PPHN): a systematic review
    Geert W 't Jong
    The Motherisk Program, Division of Clinical Pharmacology, Hospital for Sick Children, Toronto, Canada
    Reprod Toxicol 34:293-7. 2012
    ..An association between PPHN and antidepressant use in pregnancy has been reported...
  70. ncbi Uptake and depuration of the anti-depressant fluoxetine by the Japanese medaka (Oryzias latipes)
    Gordon Paterson
    Worsfold Water Quality Centre, Trent University, Peterborough, Ontario, Canada
    Chemosphere 74:125-30. 2008
    ..These results indicate longer persistence and greater potential for the bioaccumulation of fluoxetine and norfluoxetine in fish tissues than would be predicted from prior half life estimates derived using mammalian species...
  71. ncbi Reduced platelet G protein-coupled receptor kinase 2 in major depressive disorder: antidepressant treatment-induced upregulation of GRK2 protein discriminates between responder and non-responder patients
    Jesus A Garcia-Sevilla
    Laboratory of Neuropharmacology, IUNICS, University of the Balearic Islands, Palma de Mallorca, Spain
    Eur Neuropsychopharmacol 20:721-30. 2010
    ..Although this peripheral GRK2 defect does not mirror the canonical regulation of brain GRK2 in depressed suicides, it could well represent a disease state marker as well as a surrogate of response to effective antidepressant treatment...
  72. ncbi A double-blind, placebo-controlled study of aripiprazole adjunctive to antidepressant therapy among depressed outpatients with inadequate response to prior antidepressant therapy (ADAPT-A Study)
    Maurizio Fava
    Clinical Trials and Network Institute CTNI, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychother Psychosom 81:87-97. 2012
    ..We assessed the efficacy of low-dose aripiprazole added to antidepressant therapy (ADT) in major depressive disorder (MDD) patients with inadequate response to prior ADT...
  73. ncbi A single dose of the selective serotonin reuptake inhibitor citalopram exacerbates anxiety in humans: a fear-potentiated startle study
    Christian Grillon
    Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 2670, USA
    Neuropsychopharmacology 32:225-31. 2007
    ..These results indicate that a single dose of citalopram is not anxiogenic in itself, but can exacerbate the expression of fear and anxiety...
  74. ncbi Sertraline treatment of major depression in patients with acute MI or unstable angina
    Alexander H Glassman
    Department of Clinical Psychopharmacology, New York State Psychiatric Institute, 1051 Riverside Dr, Unit 116, New York, NY 10032, USA
    JAMA 288:701-9. 2002
    ..However, no published evidence exists that antidepressant drugs are safe or efficacious in patients with unstable ischemic heart disease...
  75. ncbi Cognitive toxicity of pharmacotherapeutic agents used in social anxiety disorder
    I Hindmarch
    University of Surrey, Guildford, Surrey, UK
    Int J Clin Pract 63:1085-94. 2009
    ..To compare cognitive impairment of medications used in social anxiety disorder (SAD)...
  76. ncbi Synergistic neurochemical and behavioural effects of acute intrahippocampal injection of brain-derived neurotrophic factor and antidepressants in adult mice
    Thierry Deltheil
    Universite Paris Sud, EA 3544, Faculte de Pharmacie, Chatenay Malabry, France
    Int J Neuropsychopharmacol 12:905-15. 2009
    ..Thus a BDNF+SSRI combination may offer new alternatives to treat mood disorders...
  77. pmc Dissociable effects of noradrenaline, dopamine, and serotonin uptake blockade on stop task performance in rats
    Andrea Bari
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB23EB, UK
    Psychopharmacology (Berl) 205:273-83. 2009
    ..While there is relative consensus regarding the anatomical substrates of behavioral inhibition, the neurochemical imbalance responsible for the deficits in stopping displayed by impulsive individuals is still a matter of debate...
  78. ncbi Developmental fluoxetine exposure differentially alters central and peripheral measures of the HPA system in adolescent male and female offspring
    J L Pawluski
    School for Mental Health and Neuroscience, Department of Neuroscience, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    Neuroscience 220:131-41. 2012
    ..Together, these results highlight a marked sex difference in the long-term effect of developmental exposure to SSRI medications that may differentially alter the capacity of the hippocampus to respond to stress...
  79. ncbi Occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at Spitsbergen and in Norway
    Terje Vasskog
    Department of Pharmacy, Faculty of Medicine, University of Tromsø, Tromsø, Norway
    J Chromatogr A 1185:194-205. 2008
    ..The results show higher concentrations of SSRIs outside Longyearbyen than Tromsø, possibly due to the stronger tidal currents around Tromsø. However, the concentrations are quite low, not exceeding total concentrations of 3 ng/L...
  80. ncbi Antidepressants act on glial cells: SSRIs and serotonin elicit astrocyte calcium signaling in the mouse prefrontal cortex
    Carola G Schipke
    Department of Psychiatry, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    J Psychiatr Res 45:242-8. 2011
    ..Astrocytic calcium signaling is elicited by SSRIs and 5-HT. They may serve as integrators, linking the serotonergic and glutamatergic signaling pathways...
  81. ncbi Complicated grief: a case series using escitalopram
    Naomi M Simon
    Am J Psychiatry 164:1760-1. 2007
  82. pmc Perinatal citalopram exposure selectively increases locus ceruleus circuit function in male rats
    Ryan D Darling
    Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    J Neurosci 31:16709-15. 2011
    ....
  83. pmc Action controls dopaminergic enhancement of reward representations
    Marc Guitart-Masip
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 109:7511-6. 2012
    ..These findings highlight a key role for dopamine in the generation of appetitively motivated actions...
  84. ncbi The interface of oxytocin-labeled cells and serotonin transporter-containing fibers in the primate hypothalamus: a substrate for SSRIs therapeutic effects?
    Ana B F Emiliano
    Department of Medicine, Universidade Federal da Bahia, Bahia, Brazil
    Neuropsychopharmacology 32:977-88. 2007
    ..These findings provide neuroanatomic support for the idea that SSRIs' therapeutic effects on social affiliation and anxiety may be mediated in part through components of the OT system...
  85. ncbi Superior antidepressant efficacy results of agomelatine versus fluoxetine in severe MDD patients: a randomized, double-blind study
    Anthony Hale
    Trust Headquarters, St Martin s Hospital, Canterbury, UK
    Int Clin Psychopharmacol 25:305-14. 2010
    ..In conclusion, in this study, agomelatine showed superior antidepressant efficacy over fluoxetine in treating patients with a severe episode of major depressive disorder after 8 weeks of treatment with a good tolerability profile...
  86. ncbi Early-life fluoxetine exposure reduced functional deficits after hypoxic-ischemia brain injury in rat pups
    Ying Chao Chang
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Guang University College of Medicine, Kaohsiung, Taiwan
    Neurobiol Dis 24:101-13. 2006
    ..These findings suggest that functional deficits after HI in the developing brain can be reduced by agents that enhance neural plasticity and neurogenesis through CREB activation...
  87. ncbi Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy
    Paul Scully
    Alimentary Pharmabiotic Centre and Department of Psychiatry, Cork University Hospital, Wilton, Cork, Ireland
    J Psychiatr Res 41:326-31. 2007
    ..Studies suggest that overall patients with depression show increased production of proinflammatory cytokines. We examined pro- and anti-inflammatory cytokine levels in patients who were SSRI resistant...
  88. ncbi Neonatal abstinence syndrome after in utero exposure to selective serotonin reuptake inhibitors in term infants
    Rachel Levinson-Castiel
    Neonatal Intensive Care Unit, Schneider Children s Medical Center of Israel, 14 Kaplan Street, Petah Tiqwa, Israel 49202
    Arch Pediatr Adolesc Med 160:173-6. 2006
    ..To compare the prevalence and clinical characteristics of neonatal abstinence syndrome in neonates exposed and not exposed to selective serotonin reuptake inhibitors (SSRIs) in utero...
  89. ncbi Persistent pulmonary hypertension of the newborn is associated with mode of delivery and not with maternal use of selective serotonin reuptake inhibitors
    Karen L Wilson
    Department of Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, Washington 89431 1100, USA
    Am J Perinatol 28:19-24. 2011
    ..Previous studies linking PPHN to SSRI use relied on after-the-fact patient interviews and incomplete records. Additional studies are needed to verify these results...
  90. ncbi Are psychological and pharmacologic interventions equally effective in the treatment of adult depressive disorders? A meta-analysis of comparative studies
    Pim Cuijpers
    Department of Clinical Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    J Clin Psychiatry 69:1675-85; quiz 1839-41. 2008
    ..Whether both types of intervention are equally effective has not been established definitively...
  91. ncbi Sympathetic activity in major depressive disorder: identifying those at increased cardiac risk?
    David A Barton
    Human Neurotransmitter Laboratory, Australia
    J Hypertens 25:2117-24. 2007
    ..Evidence exists linking major depressive disorder (MDD) with clinical cardiovascular events. The importance of the sympathetic nervous system in the generation of cardiac risk in other contexts is established...
  92. pmc A controlled trial of antidepressants in patients with Parkinson disease and depression
    M Menza
    Department of Psychiatry, Robert Wood Johnson Medical School, UMDNJ University Behavioral Health Care, Piscataway, NJ 08854, USA
    Neurology 72:886-92. 2009
    ..Depression affects up to 50% of these patients and is associated with a variety of poor outcomes for patients and their families. Despite this, there are few evidence-based data to guide clinical care...
  93. ncbi Co-treatment with diazepam prevents the effects of fluoxetine on the proliferation and survival of hippocampal dentate granule cells
    Xuefei Wu
    Neuroscience Center, University of Helsinki, Helsinki, Finland
    Biol Psychiatry 66:5-8. 2009
    ..Selective serotonin reuptake inhibitors increase proliferation of neuronal progenitors in rodent hippocampus after a delay of approximately 2 weeks...
  94. ncbi Pharmacologic factors associated with transient neonatal symptoms following prenatal psychotropic medication exposure
    Tim F Oberlander
    Department of Pediatrics, Centre for Community Child Health Research, University of British Columbia, L408 4480 Oak Street, Vancouver, BC, Canada V6H 3V4
    J Clin Psychiatry 65:230-7. 2004
    ..Also, this study explores relationships between neonatal outcomes and medication levels during pregnancy, at delivery, and in the newborn period...
  95. ncbi Membrane cholesterol modulates serotonin transporter activity
    S M Scanlon
    Biochemistry Department, Trinity College, Dublin 2, Ireland
    Biochemistry 40:10507-13. 2001
    ..These results suggest that membrane cholesterol modulates the functional properties of the SERT by specific molecular interactions which are needed to stabilize the transporter in its optimally active form...
  96. ncbi Paroxetine in the first trimester and the prevalence of congenital malformations
    J Alexander Cole
    i3 Drug Safety, Auburndale, MA, USA
    Pharmacoepidemiol Drug Saf 16:1075-85. 2007
    ..To refine a preliminary analysis identifying a possibly increased prevalence of malformations among infants born to women exposed to paroxetine in the first trimester...
  97. ncbi Hypothalamic-pituitary-adrenal (HPA) axis function in 3-month old infants with prenatal selective serotonin reuptake inhibitor (SSRI) antidepressant exposure
    Tim F Oberlander
    Department of Pediatrics, UBC, Vancouver, BC, Canada V6H 3V4
    Early Hum Dev 84:689-97. 2008
    ....
  98. ncbi Are we going to increase the use of antidepressants up to that of benzodiazepines?
    Arcangelo Ciuna
    Servizio Farmaceutico ULSS 20, Verona, Italy
    Eur J Clin Pharmacol 60:629-34. 2004
    ..We investigated whether the increasing use of antidepressants is associated with a progressive reduction in benzodiazepine use...
  99. pmc Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort study
    C van Walraven
    Clinical Epidemiology Unit, Ottawa Health Research Institute, Ottawa Hospital, Civic Campus, Ottawa, ON, Canada K1Y 4E9
    BMJ 323:655-8. 2001
    ..To determine the association between inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding...
  100. ncbi A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder
    Joon Hwan Jang
    Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon dong, Chongno Gu, Seoul, Korea
    Am J Psychiatry 163:1202-7. 2006
    ..The authors used proton magnetic resonance spectroscopic imaging ((1)H-MRSI) to investigate regional N-acetylaspartate level abnormalities and changes after 12 weeks of pharmacotherapy with citalopram in drug-naive OCD patients...
  101. pmc Increase in use of selective serotonin reuptake inhibitors in pregnancy during the last decade, a population-based cohort study from the Netherlands
    Marian K Bakker
    EUROCAT Registration of Congenital Anomalies, Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Br J Clin Pharmacol 65:600-6. 2008
    ..However, the extent of SSRI use in pregnancy is largely unknown...

Research Grants75

  1. Medications for Comorbid Cocaine and Alcohol Dependence
    Rolley Johnson; Fiscal Year: 2002
    ..abstract_text> ..
  2. Functional characterization of SSRI resistant genes using C. elegans
    JI Y SZE; Fiscal Year: 2010
    ..These in turn will provide clues about the genetic basis underlying the pathogenesis and offer new windows for the discovery of novel therapeutics. ..
  3. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
    ..different classes of antidepressants, (a) the tricyclic (amitriptyline, imipramine), (b) the selective serotonin uptake inhibitors (fluoxetine, sertraline) and (c) bupropion on secretion of histamine, IL-1, IL-6, IL-8, IL-13, TNF, ..
  4. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  5. 5-HT transporter function: Interaction of hormones and antidepressants
    Alan Frazer; Fiscal Year: 2013
    ..Our basic research studies could have treatment implications for patients with either MDD and/or PTSD. ..
  6. Serotonin transporter-mediated regulation of neuroendocrine exocytosis
    KEVIN P CURRIE; Fiscal Year: 2013
    ..This will provide the foundation for future expanded applications to investigate a new paradigm for 5HT / SERT mediated signal transduction. ..
  7. Serotonin Receptor Modulation of Neurotrophic Factors in the Retina
    Mark E Pennesi; Fiscal Year: 2013
    ..While some of these diseases are rare, they can lead to complete blindness, thus making their impact on public health significant. ..
  8. Oxidative Stress: A Recipe for Anxiety
    Samina Salim; Fiscal Year: 2012
    ..This proposal seeks to determine those mechanisms representing a new line of investigation that would reveal unique avenues for treatment of anxiety. ..
  9. BRAIN GLUCOSENSING NEURONS IN HEALTH AND DIABETES
    Barry E Levin; Fiscal Year: 2013
    ....
  10. Effect of Major Depression and antidepressants on human neurogenesis
    Maura Boldrini; Fiscal Year: 2013
    ..In an exploratory analysis we test the same effects for or lithium. These results have implications for understanding the pathophysiology of depression and the mode of action of antidepressants and lithium treatment. ..
  11. 5-HT transporter function: Interaction of antidepressants and hormones
    Alan Frazer; Fiscal Year: 2013
    ..The results obtained could have important implications for understanding treatment non-response in some women. ..
  12. Multigenerational FamIlial and Environmental Risk for Autism (MINERvA) Network
    Abraham Reichenberg; Fiscal Year: 2013
    ....
  13. Live imaging of brain circuitry in mouse models of PTSD
    Elaine L Bearer; Fiscal Year: 2013
    ....
  14. Trophic factors and regulation of hippocampal neuroplasticity in the human brain
    Maura Boldrini; Fiscal Year: 2012
    ..These results have implications for understanding the possibility to use trophic factors as ADT in MDD. ..
  15. Epigenetic modulation of antidepressant efficacy
    Claudia Schmauss; Fiscal Year: 2013
    ..Positive results from these studies could identify a new biomarker capable of predicting antidepressant treatment response. ..
  16. 5-HT1B receptor function in OCD
    CHRISTOPHER JOHN PITTENGER; Fiscal Year: 2012
    ..Better understanding of abnormalities in the serotonin system in OCD will pave the way for new pharmacological treatments of this severe neuropsychiatric disorder. ..
  17. Development of Novel Agents for CNS-related Diseases
    Seth Y Ablordeppey; Fiscal Year: 2012
    ..Achieving the specific aims will also provide preliminary data and improve our research environment such that we would become more competitive to apply for non-SCORE R-series grants from the NIH NIMH by the end of the grant period. ..
  18. Biomarkers for Outcomes In Late-life Depression (BOLD)
    Ian A Cook; Fiscal Year: 2010
    ..This project examines a neurophysiologic biomarker that has been tested in adults but not in depressed elders, particularly Hispanic elders, two groups that will grow dramatically in the next decades. ..
  19. Molecular Mechanisms of SSRI Action in Childhood and Adolescence
    FRANCIS SANG YONG LEE; Fiscal Year: 2010
    ....
  20. The Stress of Chronic Disease: Mineralocorticoid Mediation of Mood
    Alan Kim Johnson; Fiscal Year: 2013
    ..The proposed experiments will investigate the role of heart failure-induced aldosterone release as a depressivogenic hormonal mechanism. ..
  21. Sleep and biological rhythms after fetal exposure to antidepressants
    Amy L Salisbury; Fiscal Year: 2013
    ....
  22. Glutamatergic Mediators of Antidepressant Response in Major Depression
    Brian P Brennan; Fiscal Year: 2013
    ..Third, this study will likely provide additional insights into the role of glutamatergic dysfunction in mood disorders, expanding scientific knowledge of the pathophysiology and potential treatment of MDD. ..
  23. Massachusetts Center for Birth Defects Research and Prevention
    Allen A Mitchell; Fiscal Year: 2013
    ..Through these activities, MCBDRP will be an essential partner in BD-STEPS to achieve our overall goal of translating research findings into meaningful prevention initiatives. ..
  24. Serotonin Reuptake Inhibitors and Bone Mineralization in Adolescents
    Chadi A Calarge; Fiscal Year: 2013
    ..This is consistent with the mission of the National Institute of Mental Health. ..
  25. Modeling Neural Injury Effects of Methamphetamine Metabolism by CYP2D6 in HIV
    Mariana Cherner; Fiscal Year: 2013
    ..Results could lead to the development of pharmacologic interventions to reduce brain injury as well as inform treatment choices for meth users with HIV. ..
  26. Mechanisms Underlying Treatment-Resistant Depression and Anxiety in Mouse Models
    Benjamin A Samuels; Fiscal Year: 2013
    ..signaling in the dentate gyrus is required for mediating the effects of antidepressants Aim 3 - To determine if TGFbeta signaling activation in the dentate gyrus can convert non-responders to antidepressant treatment into responders ..
  27. INHERITED VARIATIONS IN DRUG METABOLIZING ENZYMES
    Richard M Weinshilboum; Fiscal Year: 2013
    ....
  28. Antidepressant Therapy for Functional Dyspepsia
    YURI ANN SAITO LOFTUS; Fiscal Year: 2011
    ..abstract_text> ..
  29. CYP2D6 Genotype and Cognitive Deficits in Methamphetamine Users with/without HIV
    Mariana Cherner; Fiscal Year: 2013
    ..Findings could lead to pharmacologic interventions to reduce brain injury as well as inform treatment choices for meth users with HIV or HCV infection. ..
  30. Serotonin Reuptake Inhibitors and 5-HT1A Receptors
    George Battaglia; Fiscal Year: 2009
    ..abstract_text> ..
  31. Postnatal SSRI treatment: effects on serotonergic projections and gene expression
    Neil Allen Gray; Fiscal Year: 2012
    ....
  32. Citalopram Treatment for Agitation in Alzheimer Dementia
    Constantine G Lyketsos; Fiscal Year: 2012
    ....
  33. Photoprobes for identifying potential anti-depressant and anti-anxiety medication
    DAVID JOHN LAPINSKY; Fiscal Year: 2013
    ..g., depression, anxiety, autism, obsessive- compulsive disorder) and refine SERT molecular models for computer-aided drug discovery efforts (i.e., virtual / in silico screening, structure-based drug design). ..
  34. Citalopram in First Episode Schizophrenia
    Donald C Goff; Fiscal Year: 2013
    ..In addition, the potential role of SSRI-induced BDNF release in promoting neurogenesis and improving the course of the illness offers an exciting new direction for the pharmacology of schizophrenia. ..
  35. Novel Interventions for Adults with Obsessive-Compulsive Disorder
    Carolyn I Rodriguez; Fiscal Year: 2013
    ..This study promotes the NIMH strategic plan by testing novel interventions for OCD (Strategy 3.1) and exploring a potential marker of treatment response (Strategy 1.3). ..
  36. Cellular Mechanisms in Animal Models of Depression
    John R Traynor; Fiscal Year: 2011
    ..Our aim is to identify novel targets for the development of agents to treat depressive illness. ..
  37. Physiological Implications of Serotonin Receptor Regulation
    Laura M Bohn; Fiscal Year: 2013
    ..Additional pharmaceutical therapeutics, such as selective serotonin uptake inhibitors (SSRIs) and related antidepressants, may indirectly affect activity at this receptor by altering brain ..
  38. Novel Triple Uptake Inhibitors for Treatment of Depression
    Aloke K Dutta; Fiscal Year: 2013
    ..Two most potent antidepressant molecules will be tested for their antianxiety effect and also on expression of brain derived neurotrophic factor (BDNF), implicated in the clinical action of antidepressant drugs. ..
  39. Long-Term Chamomile Therapy of Generalized Anxiety Disorder
    Jun J Mao; Fiscal Year: 2013
    ..placebo). We further hypothesize that chamomile therapy will result in a similar frequency of discontinuation symptoms and treatment-emergent adverse events (vs. placebo). ..
  40. Comparative Effectiveness and Safety of Depression Treatments during Pregnancy
    Sonia Hernandez-Diaz; Fiscal Year: 2013
    ....
  41. Promoting Evidence-Based Pharmacotherapy for PTSD in CBOCs
    Michele R Spoont; Fiscal Year: 2013
    ....
  42. The effects of methamphetamine self-administration on hippocampal serotonergic sy
    Lisa McFadden; Fiscal Year: 2013
    ..The results of these studies have the potential to contribute significantly to the understanding of, an potential therapeutic targets for, the treatment of depression associated with METH abuse. ..
  43. 2/2-Attaining and Maintaining Wellness in OCD
    Edna B Foa; Fiscal Year: 2013
    ....
  44. Cellular Mechanisms of Antidepressant Action
    Rene Hen; Fiscal Year: 2013
    ..However, only 25-50% of patients achieve remission. Therefore, there is a considerable need for new therapies. This proposal will lay the groundwork for a totally novel treatment strateav for these disorders...
  45. Biological Correlates of Traumatic Stress
    JAMES DOUGLAS BREMNER; Fiscal Year: 2013
    ..The mentorin provided by the applicant will provide an important new crop of investigators to conduct the next generation of research in the field of biological correlates of traumatic stress. ..
  46. 1/2-Novel Medication Strategies Targeting Brain Mechanisms in Pediatric OCD
    Helen Blair Simpson; Fiscal Year: 2013
    ..By developing new interventions (Objective 3) and promoting discovery in the brain (Objective 1), we advance the NIMH strategic plan. ..
  47. 2/2-Novel Medication Strategies Targeting Brain Mechanisms in Pediatric OCD
    Dikoma C Shungu; Fiscal Year: 2013
    ..By developing new interventions (Objective 3) and promoting discovery in the brain (Objective 1), we advance the NIMH strategic plan. ..
  48. Psychotherapies for Chronic Posttraumatic Stress Disorder
    John C Markowitz; Fiscal Year: 2012
    ..In response to helpful comments from reviewers, we have standardized lengths of treatment, bolstered statistical analyses, and increased sample size among other adjustments for this final submission. ..
  49. Depression treatment and risk for cardiovascular disease
    MATTHEW CHARLES WHITED; Fiscal Year: 2013
    ....
  50. Assessing the effect of FDA advisories on provider, patient, and firm behavior
    G Caleb Alexander; Fiscal Year: 2012
    ....
  51. SSRIs and Self-harm in Borderline Personality Disorder
    Michael S McCloskey; Fiscal Year: 2013
    ..At the conclusion of the eight-week randomized trial, all participants will receive eight weeks of escitalopram administered single-blind, with continued EMA and other assessment. ..
  52. Combined Mirtazapine and SSRI Treatment of PTSD: A Placebo-Controlled Trial
    Franklin R Schneier; Fiscal Year: 2012
    ..This study examines a strategy for augmenting the effect of treatment with the SSRI sertraline, by combining it with another antidepressant mirtazapine, or placebo, over 24 weeks of treatment. ..
  53. Negative Valence Brain Targets and Predictors of Anxiety and Depression Treatment
    Kinh Luan Phan; Fiscal Year: 2013
    ....
  54. Mechanisms underlying fast-onset antidepressant effects of 5-HT2C antagonists - R
    Stephanie C Dulawa; Fiscal Year: 2013
    ..In summary, the proposed work will provide valuable new insights into the mechanisms underlying fast-onset antidepressant action and lead to novel treatments. ..
  55. Risk of cocaine addiction after methylphenidate plus SSRI combination treatment
    Michela Marinelli; Fiscal Year: 2013
    ....
  56. Substrate-selective inhibition of COX-2 to target affective disorders
    Sachin Patel; Fiscal Year: 2013
    ....
  57. Amygdala Serotonin Neurotransmission and Neuropathic Pain
    Volker Neugebauer; Fiscal Year: 2013
    ..The mechanistic analysis of higher brain functions and drug targets in pain will boost basic science knowledge required for evidence-based medicine and provide translational strategies for pharmacotherapeutics and/or gene therapy. ..
  58. Clinical Implications of Serotonin in Bone
    Elizabeth M Haney; Fiscal Year: 2010
    ..abstract_text> ..
  59. RGS modulation of 5HT1A receptor signaling in depression
    John R Traynor; Fiscal Year: 2013
    ....
  60. DRUG TREATMENT OF COEXISTING PANIC AND MAJOR DEPRESSION
    ROBERT LYDIARD; Fiscal Year: 1999
    ..The selective serotonin uptake inhibitors (SSRIs) have been widely used to treat panic disorder and major depression, but there are few data on ..
  61. Adapting Exercise Treatment for Depression to Adolescents: A Pilot Study
    PHILIPPE WEINTRAUB; Fiscal Year: 2010
    ....
  62. Time Course and Potentiation of Fluoxetin Action
    George Battaglia; Fiscal Year: 2004
    ..The results of the present studies will provide the scientific foundation for the use of specific autoreceptor antagonists as adjunctive therapy with SSRIs to produce a more rapid and effective therapy of mood disorders. ..
  63. R21 Project: St. John's Wort vs. Placebo in OCD
    Kenneth Kobak; Fiscal Year: 2003
    ..35 hypericin) or matching placebo. This will be a fixed-dose design at 450 mg bid. An intent-to- treat analysis will be employed Subjects will be evaluated weekly for two weeks than bi-weekly thereafter. ..
  64. NEUROBIOLOGY AND TREATMENT OF OCD
    Wayne Goodman; Fiscal Year: 1999
    ..It is predicted that the TS-spectrum OCD subgroup will respond preferentially to risperidone addition. ..
  65. Paradoxical Antidepressant Action in Locus Coeruleus during Development
    JAY WEISS; Fiscal Year: 2009
    ....
  66. Tryptophan Metabolism, Genes, and Major Depression
    David Steffens; Fiscal Year: 2007
    ..Results from this study will help inform future treatment studies using genetics and metabolomic technology. [unreadable] [unreadable] [unreadable]..
  67. Cocaine behavior: Regulation by k-opioids and serotonin
    Sari Izenwasser; Fiscal Year: 2009
    ..For example, dopamine antagonists, opioid antagonists and serotonin uptake inhibitors can all reduce cocaine self-administration...
  68. Sertraline Pharmacotherapy for Alcoholism Subtypes
    Henry Kranzler; Fiscal Year: 2007
    ..abstract_text> ..
  69. SEROTONERGIC MECHANISMS IN SLEEP AND DEPRESSION
    JOHN GILLIN; Fiscal Year: 2000
    ....
  70. Cytokine-induced depression & the serotonin transporter
    Richard Sloan; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  71. Antidepressants - same effect on mesolimbic DA activity?
    JAY WEISS; Fiscal Year: 2009
    ....
  72. SEROTONIN RECEPTOR LIGANDS FOR SPECT IMAGING
    HANK KUNG; Fiscal Year: 2004
    ..The novel imaging agents may lead to simple and useful routine diagnostic procedures for various mental health diseases involving SERT in the brain. ..
  73. SEROTONIN RECEPTOR LIGANDS FOR SPECT IMAGING
    HANK KUNG; Fiscal Year: 2001
    ..The novel imaging agents may lead to simple and useful routine diagnostic procedures for various mental health diseases involving SERT in the brain. ..
  74. SERTRALINE AND COGNITIVE THERAPY IN DEPRESSED ALCOHOLICS
    Darlene Moak; Fiscal Year: 1999
    ....