non sedating histamine h1 antagonists

Summary

Summary: A class of non-sedating drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.

Top Publications

  1. ncbi Effects of olopatadine hydrochloride, an antihistamine drug, on skin inflammation induced by repeated topical application of oxazolone in mice
    T Tamura
    Pharmaceutical Research Center, Kyowa Hakko Kogyo Co Ltd, 1188 Shimotogari, Nagaizumi cho, Sunto gun, Shizuoka 411 8731, Japan
    Br J Dermatol 151:1133-42. 2004
  2. ncbi Safety of levocetirizine treatment in young atopic children: An 18-month study
    F Estelle R Simons
    Department of Pediatrics and Child Health, Canadian Institutes of Health Research National Training Program in Allergy and Asthma, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Pediatr Allergy Immunol 18:535-42. 2007
  3. ncbi Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans
    M Molimard
    Departement de Pharmacologie, Centre Hospitalier Universitaire, Bordeaux, France
    Fundam Clin Pharmacol 18:399-411. 2004
  4. ncbi [The effect of 5-days of cetirizine, desloratadine, fexofenadine 120 and 180 mg, levocetirizine, loratadine treatment on the histamine-induced skin reaction and skin blood flow--a randomized, double-blind, placebo controlled trial]
    Krzysztof Kłos
    Department of Infectious Diseases and Allergology, Military Institute of the Heath Service in Warsaw, Central Clinical Hospital of the Ministry of National Defence
    Pol Merkur Lekarski 21:449-53. 2006
  5. ncbi [Inhibition of histamine-induced wheel after a recommended single dose administration of 10 mg cetirizine, 5 mg desloratadine, 120 i 180 mg fexofenadine, 5 mg levocetirizine and 10 mg loratadine--a randomized, double-blind, placebo controlled trial]
    Jerzy Kruszewski
    Department of Infectious Diseases and Allergology, Military Institute of the Heath Service in Warsaw, Central Clinical Hospital of the Ministry of National Defence
    Pol Merkur Lekarski 21:443-8. 2006
  6. ncbi Inhibition of cytokine-induced expression of T-cell cytokines by antihistamines
    M S Ashenager
    Department of Dermatology, Kinki University School of Medicine, Osaka, Japan
    J Investig Allergol Clin Immunol 17:20-6. 2007
  7. ncbi Selecting the optimal oral antihistamine for patients with allergic rhinitis
    Jeffrey M Lehman
    Department of Pediatrics, Division of Clinical Allergy and Immunology, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Drugs 66:2309-19. 2006
  8. ncbi Montelukast with desloratadine or levocetirizine for the treatment of persistent allergic rhinitis
    Maciej Ciebiada
    Department of Pneumology and Allergy, Medical University of Lodz, Lodz, Poland
    Ann Allergy Asthma Immunol 97:664-71. 2006
  9. ncbi Randomized placebo-controlled trial comparing desloratadine and montelukast in monotherapy and desloratadine plus montelukast in combined therapy for chronic idiopathic urticaria
    Gabriele Di Lorenzo
    Dipartimento di Medicina Clinica e delle Patologie Emergenti, Universita di Palermo, 90127 Palermo, Italy
    J Allergy Clin Immunol 114:619-25. 2004
  10. ncbi Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography
    Manabu Tashiro
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Clin Pharmacol 44:890-900. 2004

Research Grants

Detail Information

Publications228 found, 100 shown here

  1. ncbi Effects of olopatadine hydrochloride, an antihistamine drug, on skin inflammation induced by repeated topical application of oxazolone in mice
    T Tamura
    Pharmaceutical Research Center, Kyowa Hakko Kogyo Co Ltd, 1188 Shimotogari, Nagaizumi cho, Sunto gun, Shizuoka 411 8731, Japan
    Br J Dermatol 151:1133-42. 2004
    ..Olopatadine hydrochloride (olopatadine) is one of the second-generation antihistamines, which is prescribed for allergic disorders such as rhinitis, urticaria and eczema dermatitis...
  2. ncbi Safety of levocetirizine treatment in young atopic children: An 18-month study
    F Estelle R Simons
    Department of Pediatrics and Child Health, Canadian Institutes of Health Research National Training Program in Allergy and Asthma, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Pediatr Allergy Immunol 18:535-42. 2007
    ..The long-term safety of levocetirizine has been confirmed in young atopic children...
  3. ncbi Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans
    M Molimard
    Departement de Pharmacologie, Centre Hospitalier Universitaire, Bordeaux, France
    Fundam Clin Pharmacol 18:399-411. 2004
    ....
  4. ncbi [The effect of 5-days of cetirizine, desloratadine, fexofenadine 120 and 180 mg, levocetirizine, loratadine treatment on the histamine-induced skin reaction and skin blood flow--a randomized, double-blind, placebo controlled trial]
    Krzysztof Kłos
    Department of Infectious Diseases and Allergology, Military Institute of the Heath Service in Warsaw, Central Clinical Hospital of the Ministry of National Defence
    Pol Merkur Lekarski 21:449-53. 2006
    ....
  5. ncbi [Inhibition of histamine-induced wheel after a recommended single dose administration of 10 mg cetirizine, 5 mg desloratadine, 120 i 180 mg fexofenadine, 5 mg levocetirizine and 10 mg loratadine--a randomized, double-blind, placebo controlled trial]
    Jerzy Kruszewski
    Department of Infectious Diseases and Allergology, Military Institute of the Heath Service in Warsaw, Central Clinical Hospital of the Ministry of National Defence
    Pol Merkur Lekarski 21:443-8. 2006
    ..The aim of the study was to compare the effect of inhibition skin reactivity after administration of single dose administration of various second generation antihistamines in the healthy people group...
  6. ncbi Inhibition of cytokine-induced expression of T-cell cytokines by antihistamines
    M S Ashenager
    Department of Dermatology, Kinki University School of Medicine, Osaka, Japan
    J Investig Allergol Clin Immunol 17:20-6. 2007
    ..To investigate immunomodulatory properties of 4 antihistamines available in Japan...
  7. ncbi Selecting the optimal oral antihistamine for patients with allergic rhinitis
    Jeffrey M Lehman
    Department of Pediatrics, Division of Clinical Allergy and Immunology, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Drugs 66:2309-19. 2006
    ..In addition to the clinical efficacy, potential for improvement in QOL with a particular treatment should also be considered...
  8. ncbi Montelukast with desloratadine or levocetirizine for the treatment of persistent allergic rhinitis
    Maciej Ciebiada
    Department of Pneumology and Allergy, Medical University of Lodz, Lodz, Poland
    Ann Allergy Asthma Immunol 97:664-71. 2006
    ..Montelukast sodium is approved as a treatment for intermittent and persistent allergic rhinitis (AR), but it has not been evaluated as combined therapy with antihistamines for persistent AR...
  9. ncbi Randomized placebo-controlled trial comparing desloratadine and montelukast in monotherapy and desloratadine plus montelukast in combined therapy for chronic idiopathic urticaria
    Gabriele Di Lorenzo
    Dipartimento di Medicina Clinica e delle Patologie Emergenti, Universita di Palermo, 90127 Palermo, Italy
    J Allergy Clin Immunol 114:619-25. 2004
    ..Recently, antileukotriene receptors have been used in patients with CIU, either administered as monotherapy or combined with H 1 -receptor antagonists...
  10. ncbi Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography
    Manabu Tashiro
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Clin Pharmacol 44:890-900. 2004
    ..H1RO was negligible with fexofenadine (-0.1%) but moderately high with cetirizine (26.0%). In conclusion, fexofenadine 120 mg is distinguishable from cetirizine 20 mg, as assessed by H1RO and psychomotor testing...
  11. ncbi Antihistamines: do they work? Further well-controlled trials involving larger samples are needed
    F Fumagalli
    Allergy and Respiratory Diseases, DIMI, Genoa University, Genoa, Italy
    Allergy 59:74-7. 2004
    ..The anti-inflammatory effects of cetirizine, desloratadine and levocetirizine are reviewed. Quality of life is considered too, as a main parameter in a global evaluation of the antihistamine's effects...
  12. ncbi Comparative efficacy of wheal-and-flare suppression among various non-sedating antihistamines and the pharmacologic insights to their efficacy
    Sukit Roongapinun
    Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Thailand
    J Med Assoc Thai 87:551-6. 2004
    ..This study examined the time-of-onset and compared the 95% inhibitory effect of these agents on histamine-induced cutaneous reaction so as to understand the diversity of their efficacy...
  13. ncbi Comparative efficacy of cetirizine and fexofenadine in the treatment of chronic idiopathic urticaria
    S Handa
    Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Dermatolog Treat 15:55-7. 2004
    ..The present study was designed considering the lack of reports comparing the efficacy and safety of commonly prescribed cetirizine and fexofenadine in the treatment of CIU...
  14. ncbi Comparison of the combinations of fexofenadine-pseudoephedrine and loratadine-montelukast in the treatment of seasonal allergic rhinitis
    Rizwan Moinuddin
    Section of Otolaryngology Head and Neck Surgery, The Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Ann Allergy Asthma Immunol 92:73-9. 2004
    ..Antihistamine-decongestant combinations are used routinely for the treatment of seasonal allergic rhinitis. Recently, the combination of an antihistamine and a leukotriene receptor antagonist has been shown to be efficacious...
  15. ncbi Comparative clinical efficacy, onset and duration of action of levocetirizine and desloratadine for symptoms of seasonal allergic rhinitis in subjects evaluated in the Environmental Exposure Unit (EEU)
    J H Day
    Division of Allergy and Immunology, Kingston General Hospital, Kingston, Ontario, Canada
    Int J Clin Pract 58:109-18. 2004
    ..007) on day 1; and better than placebo (p = 0.014) after the second dose on day 2, which was not observed with desloratadine. Levocetirizine and desloratadine were safe and well tolerated...
  16. ncbi [Respiratory allergies in the child and the adult]
    Antoine Magnan
    EA 3287 Université de la Méditerranée et Service de pneumo allergologie, Hopital Sainte Marguerite, 13274 Marseille 09
    Rev Prat 54:189-98. 2004
  17. ncbi Levocetirizine better protects than desloratadine in a nasal provocation with allergen
    Cédric Déruaz
    Division of Allergy and Immunology, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon, 1011 Lausanne, Switzerland
    J Allergy Clin Immunol 113:669-76. 2004
    ..Newly available antihistamine preparations, levocetirizine, the R-enantiomer of racemate cetirizine, and desloratadine, an active metabolite of loratadine, have been recently released for allergic rhinitis...
  18. ncbi Onset of action for the relief of allergic rhinitis symptoms with second-generation antihistamines
    William A Greisner
    Allergy and Asthma Associates of the Bluegrass, Lexington, Kentucky, USA
    Allergy Asthma Proc 25:81-3. 2004
    ..The literature search did not reveal any published onset of action studies for desloratadine. The onset of action for a given second-generation antihistamine depends on how it is defined and subsequently measured...
  19. ncbi Efficacy of fexofenadine versus desloratadine in suppressing histamine-induced wheal and flare
    Eli O Meltzer
    Allergy and Asthma Medical Group and Research Center, University of California at San Diego, San Diego, California, USA
    Allergy Asthma Proc 28:67-73. 2007
    ..Fexofenadine HCl, 180 mg, was superior to desloratadine, 5 mg, in histamine-induced wheal-and-flare suppression, suggesting increased in vivo H1-receptor antagonist potency of fexofenadine versus desloratadine...
  20. ncbi Levocetirizine: the allergist's arsenal grows larger
    R Matthew Bloebaum
    The University of Texas Medical Branch, Department of Internal Medicine, Allergy and Immunology Division, Medical Research Bldg 8 104, 301 University Boulevard, Galveston, Texas 77555 1083, USA
    Expert Opin Pharmacother 5:1581-8. 2004
    ..Furthermore, clinical trials indicate that it is safe and effective for the treatment of allergic rhinitis and chronic urticaria with a minimal amount of untoward effects...
  21. ncbi New antihistamines: a critical view
    Inês Cristina Camelo-Nunes
    Departamento de Pediatria, Universidade Federal de Sao Paulo Escola Paulista de Medicina UNIFESP EPM, Sao Paulo, SP, Brazil
    J Pediatr (Rio J) 82:S173-80. 2006
    ..To perform a critical evaluation of the more recent H1 antihistamines and the various terms used to describe them, based on a review of evidence on their role in the treatment of allergic disorders...
  22. ncbi Modern histamine H1-receptor antagonists in the unified airway
    Daniel K C Lee
    J Allergy Clin Immunol 114:698; author reply 698-9. 2004
  23. ncbi Desloratadine in combination with montelukast suppresses the dermographometer challenge test papule, and is effective in the treatment of delayed pressure urticaria: a randomized, double-blind, placebo-controlled study
    E Nettis
    Department of Medical Clinic, Immunology and Infectious Diseases, Division of Allergy and Clinical Immunology, University of Bari Medical School, Bari, Italy
    Br J Dermatol 155:1279-82. 2006
    ..Lesion onset is typically 3-12 h after the application of pressure, and lesions may persist for more than 24 h. The treatment of DPU is often unsatisfactory...
  24. ncbi Management of seasonal allergic rhinitis: comparative efficacy of the newer-generation prescription antihistamines
    Kathleen Conboy-Ellis
    University of Tampa, Tampa, FL 33606, USA
    J Am Acad Nurse Pract 17:295-301. 2005
    ....
  25. pmc Facial thermography is a sensitive tool to determine antihistaminic activity: comparison of levocetirizine and fexofenadine
    Michael Larbig
    Fraunhofer Institute for Toxicology and Experimental Medicine, Hanover, Germany
    Br J Clin Pharmacol 62:158-64. 2006
    ....
  26. ncbi [Therapeutic options in idiopathic chronic urticaria]
    Patricia Montero Mora
    Servicio de alergia e inmunologia clinica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, IMSS
    Rev Alerg Mex 52:77-82. 2005
    ..There are improvements with leukotriene receptor antagonists...
  27. ncbi [Nasal budesonide plus zafirlukast vs nasal budesonide plus loratadine-pseudoephedrine for controlling the symptoms of rhinitis and asthma]
    Hector Hugo Salas Benitez
    Serivico de alergia e inmunnologia clínica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Mexico
    Rev Alerg Mex 52:90-5. 2005
    ..To compare the efficacy of nasal budesonide plus oral zafirlukast against nasal budesonide plus oral loratadine/pseudoephedrine combination in the control of symptoms of rhinitis and asthma...
  28. ncbi Desloratadine and levocetirizine improve nasal symptoms, airflow, and allergic inflammation in patients with perennial allergic rhinitis: a pilot study
    Giorgio Ciprandi
    Allergologia U O ORL, Dipartimento Regionale Testa Collo, Padiglione Specialità piano terzo, Ospedale San Martino, Largo R Benzi 10, 16132, Genoa, Italy
    Int Immunopharmacol 5:1800-8. 2005
    ..Nasal obstruction is the main symptom in patients with perennial allergic rhinitis. Some new antihistamines have been demonstrated to be capable of improving this symptom...
  29. ncbi Influence of cetirizine and loratadine on granulocyte-macrophage colony-stimulating factor and interleukin-8 release in A549 human airway epithelial cells stimulated with interleukin-1beta
    Kuo Chu Cheng
    Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan
    J Microbiol Immunol Infect 39:206-11. 2006
    ....
  30. ncbi Efficacy of diphenhydramine vs desloratadine and placebo in patients with moderate-to-severe seasonal allergic rhinitis
    Gordon D Raphael
    Pfizer Consumer Healthcare, Morris Plains, New Jersey 07950, USA
    Ann Allergy Asthma Immunol 96:606-14. 2006
    ..Previous studies have shown that diphenhydramine and desloratadine effectively relieve symptoms of seasonal allergic rhinitis (SAR)...
  31. ncbi Levocetirizine in the treatment of chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled study
    E Nettis
    Department of Medical Clinics, Immunology and Infectious Diseases, Section of Allergy and Clinical Immunology, University of Bari, Piazza, Italy
    Br J Dermatol 154:533-8. 2006
    ..Chronic urticaria is a common skin condition. It is frequently a disabling disease because of the persistence of clinical symptoms, the unpredictable course and its negative influence on the quality of life...
  32. pmc Levocetirizine has a longer duration of action on improving total nasal symptoms score than fexofenadine after single administration
    Friedrich Horak
    Vienna General Hospital AKH, Department of Otorhinolaryngology, Vienna, Austria
    Br J Clin Pharmacol 60:24-31. 2005
    ..The latter is an environment where subjects can be exposed to specific aeroallergens in controlled and reproducible conditions allowing for precise comparisons of anti-allergic drugs...
  33. pmc Inflammatory basis of exercise-induced bronchoconstriction
    Teal S Hallstrand
    Department of Medicine, Division of Pulmonary and Critical Care, University of Washington, Seattle, Washington 98195 6522, USA
    Am J Respir Crit Care Med 172:679-86. 2005
    ..Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition with unclear pathogenesis. Two competing theories of the pathogenesis of EIB differ regarding the inflammatory basis of this condition...
  34. ncbi An evaluation of the ocular drying effects of 2 systemic antihistamines: loratadine and cetirizine hydrochloride
    George W Ousler
    Ophthalmic Research Associates Inc, North Andover, Massachusetts 01845, USA
    Ann Allergy Asthma Immunol 93:460-4. 2004
    ..Systemic antihistamines, such as loratadine and cetrizine hydrochloride, have proven efficacious in the control of many allergic conditions; however, patients complain about their drying effects...
  35. pmc Retrospective population pharmacokinetics of levocetirizine in atopic children receiving cetirizine: the ETAC study
    Ziad Hussein
    Medeval Ltd, Skelton House, Manchester Science Park, Lloyd Street North, Manchester M15 6SH, UK
    Br J Clin Pharmacol 59:28-37. 2005
    ..To evaluate the population pharmacokinetics of levocetirizine in young children receiving long-term treatment with cetirizine...
  36. ncbi [Oral second generation antihistamines in allergic rhinitis]
    H Riechelmann
    Univ HNO Klinik Ulm
    Laryngorhinootologie 84:30-41. 2005
    ..Histamine is a key mediator of the allergic immediate reaction. Antihistamines belong to the most frequently used treatment modalities in allergic rhinitis...
  37. ncbi Effects of levocetirizine as add-on therapy to fluticasone in seasonal allergic rhinitis
    M L Barnes
    Asthma and Allergy Research Group, Department of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Clin Exp Allergy 36:676-84. 2006
    ..Addition of H(1) antagonists to intranasal corticosteroid treatment of allergic rhinitis (AR) is common in clinical practice and recommended by guidelines, despite some evidence that the additive benefits are negligible...
  38. ncbi Comparison of the risk of drowsiness and sedation between levocetirizine and desloratadine: a prescription-event monitoring study in England
    Deborah Layton
    Drug Safety Research Unit, Southampton, Hants, UK
    Drug Saf 29:897-909. 2006
    ....
  39. ncbi A comparison of levocetirizine and desloratadine in the histamine-induced wheal and flare response in human skin in vivo
    T A Popov
    Clinical Centre of Allergology, Medical University, 1, Sv Georgi Sofiyski St, 1431, Sofia, Bulgaria
    Inflamm Res 55:241-4. 2006
    ..The histamine-induced wheal and flare response was used to compare quantitatively the antihistaminic potency of levocetirizine and desloratadine...
  40. ncbi Rupatadine 10 mg and cetirizine 10 mg in seasonal allergic rhinitis: a randomised, double-blind parallel study
    C Martinez-Cocera
    Allergology Department, Hospital Clinico San Carlos, Madrid
    J Investig Allergol Clin Immunol 15:22-9. 2005
    ..5% of patients treated with rupatadine or cetirizine, respectively. The most reported AEs (67%) were mild in intensity. Our results suggest that rupatadine 10 mg may be a valuable and safe alternative for the symptomatic treatment of SAR...
  41. ncbi Levocetirizine for treatment of immediate and delayed mosquito bite reactions
    Ari Karppinen
    Department of Dermatology, University and University Hospital of Tampere, Finland
    Acta Derm Venereol 86:329-31. 2006
    ..016). These results show that prophylactic levocetirizine 5 mg is an effective treatment for both immediate and delayed mosquito bite symptoms and is especially effective in subjects with large wheals...
  42. ncbi Levocetirizine is an effective treatment in patients suffering from chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, parallel, multicenter study
    Alexander Kapp
    Department of Dermatology and Allergology, Hannover Medical University, Hannover, Germany
    Int J Dermatol 45:469-74. 2006
    ..Symptoms include short-lived wheals, itching, and erythema. CIU impedes significantly a patient's quality of life (QoL). Levocetirizine is an antihistamine from the latest generation approved for CIU...
  43. ncbi The addition of zafirlukast to cetirizine improves the treatment of chronic urticaria in patients with positive autologous serum skin test results
    Scott E Bagenstose
    Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0563, USA
    J Allergy Clin Immunol 113:134-40. 2004
    ..Because leukotrienes have potent local effects on cutaneous vasculature, leukotriene antagonists might be effective in the treatment of chronic urticaria...
  44. ncbi Analysis of disease-dependent sedative profiles of H(1)-antihistamines by large-scale surveillance using the visual analog scale
    N Izumi
    Department of Molecular Pharmacology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Methods Find Exp Clin Pharmacol 30:225-30. 2008
    ..Therefore, appropriate H(1)-antihistamines may need to be selected, depending on allergic diseases, to improve patients' QOL...
  45. ncbi Rapid effects of olopatadine hydrochloride on the histamine-induced skin responses
    Keisuke Morita
    Department of Dermatology, Graduate School of Medical Sciences, Fukuoka, Japan
    J Dermatol 29:709-12. 2002
    ..Thus, olopatadine hydrochloride exhibited a very rapid and potent antihistamine effect on the histamine-induced skin responses...
  46. ncbi The new antihistamines--desloratadine and levocetirizine: a review
    Noah Scheinfeld
    Department of Dermatology, St Luke s Roosevelt Hospital Center, 1090 Amsterdam Ave Suite 11D, NY, NY 10025, USA
    J Drugs Dermatol 1:311-6. 2002
  47. pmc Inhibition of allergen-induced wheal and flare reactions by levocetirizine and desloratadine
    Nelly Frossard
    Faculty of Pharmacy, University Louis Pasteur Strasbourg I, Strasbourg, France
    Br J Clin Pharmacol 65:172-9. 2008
    ..Some of the newest antihistamines have already been compared in a head-to-head setting using this model. However, their objective action at inhibiting the allergen-induced wheal and flare response has not been reported yet...
  48. ncbi [Clinical aspects of anti-inflammatory action of antihistamines]
    Iwona Grzelewska-Rzymowska
    Wojskowy Instytut Medyczny, Klinika Chorób Wewnetrznych, Pneumonologii i Alergologii CSK MON w Warszawie
    Pol Merkur Lekarski 14:634-8. 2003
    ..In the paper some anti-inflammatory effects of antihistamines have been presented, and their action mechanisms and clinical applications have been discussed in relation to the new preparates of antihistamines...
  49. ncbi Driving ability after acute and sub-chronic administration of levocetirizine and diphenhydramine: a randomized, double-blind, placebo-controlled trial
    Joris C Verster
    Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Psychopharmacology (Berl) 169:84-90. 2003
    ..Sedation following antihistamine use poses a danger to ambulant patients involved in daily activities such as driving...
  50. ncbi The combination of single-dose montelukast and loratadine on exercise-induced bronchospasm in children
    D G Peroni
    Clinica Pediatrica, University of Verona, Italy
    Eur Respir J 20:104-7. 2002
    ....
  51. ncbi H1-antihistamine treatment in young atopic children: effect on urticaria
    F Estelle R Simons
    Department of Pediatrics, Canadian Institutes of Health Research National Training Program in Allergy and Asthma, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Ann Allergy Asthma Immunol 99:261-6. 2007
    ..There are few published, randomized, double-masked, placebo-controlled, clinical trials of interventions for urticaria in the pediatric population...
  52. ncbi A direct comparison of the efficacy of antihistamines in SAR and PAR: randomised, placebo-controlled studies with levocetirizine and loratadine using an environmental exposure unit - the Vienna Challenge Chamber (VCC)
    P Stübner
    ENT University Clinic Vienna, Austria
    Curr Med Res Opin 20:891-902. 2004
    ....
  53. ncbi Levocetirizine does not prolong the QT/QTc interval in healthy subjects: results from a thorough QT study
    Réginald Hulhoven
    Clinical Pharmacology, UCB Pharma SA, Chemin du Foriest 1420, Braine l Alleud, Belgium
    Eur J Clin Pharmacol 63:1011-7. 2007
    ..To conduct a thorough QT study of levocetirizine, a non-sedating antihistamine, in accordance with International Conference on Harmonisation (ICH) E14 guidance...
  54. ncbi Efficacy and central nervous system impairment of newer-generation prescription antihistamines in seasonal allergic rhinitis
    Dennis L Spangler
    Atlanta Allergy and Asthma Clinic, 1965 N Park Place, N W, Atlanta, GA 30339, USA
    South Med J 99:593-9. 2006
    ..It is essential that appropriate treatment relieves SAR symptoms with absent or minimal adverse events. This is particularly important for those patients involved in skilled and cognitive activities or safety-critical jobs...
  55. ncbi Efficacy and tolerability of newer antihistamines in the treatment of allergic conjunctivitis
    Leonard Bielory
    Department of Medicine, Pediatrics and Ophthalmology, Division of Allergy, Immunology and Rheumatology, UMDNJ New Jersey Medical School, Immuno Ophthalmology Service, 90 Bergen Street, DOC Suite 4700, Newark, NJ 07103, USA
    Drugs 65:215-28. 2005
    ..Lastly, topical corticosteroids may be considered for severe seasonal ocular allergy symptoms, although long-term use should be avoided because of risks of ocular adverse effects, including glaucoma and cataract formation...
  56. ncbi Comparative tolerability of second generation antihistamines
    F Horak
    ENT Clinic, University of Vienna, Austria
    Drug Saf 20:385-401. 1999
    ..Taking into account their negligible CNS activity, the low incidence of cardiovascular adverse effects, their lack of anticholinergic effects and other benefits, this class of antiallergic drugs represents a definite advance in therapy...
  57. ncbi Evaluation of treatment satisfaction in children with allergic disease treated with an antihistamine: an international, non-interventional, retrospective study
    Marta Ferrer
    Department of Allergy, Clinica Universidad de Navarra Medical School, 31080 Pamplona, Spain
    Clin Drug Investig 30:15-34. 2010
    ....
  58. ncbi Inhibition of depolarization-induced [3H]noradrenaline release from SH-SY5Y human neuroblastoma cells by some second-generation H(1) receptor antagonists through blockade of store-operated Ca(2+) channels (SOCs)
    M Taglialatela
    Unit of Pharmacology, Department of Neuroscience, University of Naples Federico II, School of Medicine, Via S Pansini 5, I 80131, Naples, Italy
    Biochem Pharmacol 62:1229-38. 2001
    ..Collectively, the results of the present study suggest that, in SH-SY5Y human neuroblastoma cells, the inhibition of SOCs by some second-generation antihistamines can prevent depolarization-induced neurotransmitter release...
  59. ncbi First do no harm: managing antihistamine impairment in patients with allergic rhinitis
    Thomas B Casale
    Creighton University, School of Medicine, Omaha, NE 68131, USA
    J Allergy Clin Immunol 111:S835-42. 2003
    ..In addition, further epidemiologic studies on the effects of antihistamines should be performed...
  60. ncbi Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines
    M Taglialatela
    Section of Pharmacology, Department of Neuroscience, School of Medicine, University of Naples Federico II, 80131 Naples, Italy
    Mol Pharmacol 54:113-21. 1998
    ....
  61. ncbi In vitro inhibition of human liver drug metabolizing enzymes by second generation antihistamines
    J M Nicolas
    Department of Product Safety and Metabolism, UCB S A Pharma Sector, Braine, l Alleud, Belgium
    Chem Biol Interact 123:63-79. 1999
    ....
  62. ncbi Ebastine: an update of its use in allergic disorders
    M Hurst
    Adis International Limited, Mairangi Bay, Auckland, New Zealand
    Drugs 59:981-1006. 2000
    ..The incidence of adverse events during ebastine treatment is not significantly greater than that observed with placebo or other second-generation antihistamines...
  63. ncbi Cardiac ion channels and antihistamines: possible mechanisms of cardiotoxicity
    M Taglialatela
    Section of Pharmacology, Department of Neuroscience, School of Medicine, University of Naples Federico II, Italy
    Clin Exp Allergy 29:182-9. 1999
    ....
  64. ncbi Antihistamines and driving ability: evidence from on-the-road driving studies during normal traffic
    Joris C Verster
    Utrecht Institute for Pharmaceutical Sciences, Department of Psychopharmacology, University of Utrecht, Utrecht, The Netherlands
    Ann Allergy Asthma Immunol 92:294-303; quiz 303-5, 355. 2004
    ..All antihistamines are capable of crossing the blood-brain barrier and thus may cause sedation. Most antihistamine users are ambulatory patients and therefore presumably drive a car...
  65. ncbi Costs of second-generation antihistamines in the treatment of allergic rhinitis: US perspective
    Joel W Hay
    University of Southern California Center for the Health Professions, Los Angeles, CA 90033, USA
    Curr Med Res Opin 25:1421-31. 2009
    ..To review the pharmacoeconomic literature evaluating use of antihistamines in treating allergic rhinitis (AR) in the US...
  66. ncbi Second-generation antihistamines for the treatment of chronic idiopathic urticaria
    Donald V Belsito
    Department of Internal Medicine, Division of Dermatology, University of Missouri Kansas City, Kansas City, MO, USA
    J Drugs Dermatol 9:503-12. 2010
    ..More studies are required to further assess receptor occupancy and other factors that may differentiate the second-generation H1 antihistamines...
  67. ncbi Terfenadine alters action potentials in isolated canine Purkinje fibers more than acrivastine
    D G Lang
    Division of Pharmacology, Burroughs Wellcome, Research Triangle Park, North Carolina 27709
    J Cardiovasc Pharmacol 22:438-42. 1993
    ....
  68. ncbi Brompheniramine, terfenadine, and placebo in allergic rhinitis
    G L Klein
    American Society for Clinical Pharmacology and Therapeutics ASCPT, San Diego, CA, USA
    Ann Allergy Asthma Immunol 77:365-70. 1996
    ..Second-generation antihistamines, reported to lack central nervous system depressant activity, may be considered to have a clinical advantage over traditional antihistamines...
  69. ncbi Effect of desloratadine on epithelial cell granulocyte-macrophage colony-stimulating factor secretion and eosinophil survival
    J Mullol
    IDIBAPS, Rhinology Unit, ENT Department, Hospital Clinic, Deparmtent of Medicine, Universitat de Barcelona, Barcelona, Catalonia, Spain
    Clin Exp Allergy 36:52-8. 2006
    ..Second-generation antihistamines are H(1) receptor antagonists and may have additional anti-inflammatory effects...
  70. ncbi Second generation antihistamines in the treatment of seasonal allergic rhinitis due to Parietaria and cypress pollen
    L Macchia
    Department of Allergology and Clinical Immunology, University of Bari, 70124 Bari, Italy
    Pharmacol Res 44:461-6. 2001
    ..However, no statistically significant inter-group differences could be detected...
  71. ncbi Non-sedating antihistamines in the treatment of chronic idiopathic urticaria using patient-reported outcomes
    J J Grob
    Service de Dermatologie, Hopital Ste Marguerite, Marseille, France
    Curr Med Res Opin 24:2423-8. 2008
    ..Thus, patient-reported outcome (PRO) measures, using validated scoring instruments, are probably the most accurate tools available for assessing the efficacy of medications that treat CIU, such as second-generation antihistamines...
  72. ncbi Second-generation antihistamines: actions and efficacy in the management of allergic disorders
    Larry K Golightly
    Pharmacy Care Team, University of Colorado Hospital, Denver, Colorado 80262, USA
    Drugs 65:341-84. 2005
    ....
  73. ncbi [Clinical effects of olopatadine hydrochloride on pruritus in skin diseases]
    Mariko Niide
    Department of Dermatology, Tokyo Medical University
    Arerugi 55:1327-36. 2006
    ..The clinical effects of second generation antihistamines on pruritus caused by various skin diseases were examined by keeping a daily record of their effects...
  74. ncbi Antihistamine effects on prefrontal cortex activity during working memory process in preschool children: a near-infrared spectroscopy (NIRS) study
    Takeo Tsujii
    Center for Advanced Research on Logic and Sensibility CARLS, Mita 3 1 7, Minato ku, Tokyo 108 0073, Japan
    Neurosci Res 67:80-5. 2010
    ..Also discussed is the utility of the NIRS technique in neuropsychopharmacological studies of children...
  75. ncbi Quality of life in allergic rhinitis
    M S Blaiss
    Division of Clinical Immunology, University of Tennessee, Memphis, USA
    Ann Allergy Asthma Immunol 83:449-54. 1999
    ....
  76. ncbi Olopatadine hydrochloride suppresses the rebound phenomenon after discontinuation of treatment with a topical steroid in mice with chronic contact hypersensitivity
    T Tamura
    Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, Shizuoka, Japan
    Clin Exp Allergy 35:97-103. 2005
    ..Although topical steroids have widely been prescribed for atopic dermatitis, a relapse often occurs within several days after discontinuation of their prolonged use...
  77. ncbi A dose-ranging study of the effects of mequitazine on actual driving, memory and psychomotor performance as compared to dexchlorpheniramine, cetirizine and placebo
    E L Theunissen
    Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Faculty of Psychology, Maastricht University, The Netherlands
    Clin Exp Allergy 34:250-8. 2004
    ..Mequitazine is a so-called 'non-sedative' second-generation antihistamine even though it has never been firmly established that this drug's sedative potential actually differs from that of the 'sedative' first-generation antihistamines...
  78. ncbi P-glycoprotein influences the brain concentrations of cetirizine (Zyrtec), a second-generation non-sedating antihistamine
    Joseph W Polli
    Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Inc, P O Box 13398, Room MAI 2213 2G, Research Triangle Park, North Carolina 27709, USA
    J Pharm Sci 92:2082-9. 2003
    ....
  79. ncbi Assessment of the first and second generation antihistamines brain penetration and role of P-glycoprotein
    Tanja Obradovic
    Absorption Systems, Oaklands Corporate Center, 440 Creamery Way, Suite 300, Exton, Pennslyvania 19341 2554, USA
    Pharm Res 24:318-27. 2007
    ..The objective of this work was to evaluate the role of Pgp in brain penetration of first and second generation antihistamines...
  80. ncbi Allergic rhinitis and impairment issues in schoolchildren: a consensus report
    Michael S Blaiss
    University of Tennessee Health Science Center, Germantown, TN 38138, USA
    Curr Med Res Opin 20:1937-52. 2004
    ..Most notably, it can impede learning during the school-age years. Other consequences include adverse behavioral and psychosocial effects, poor quality of life, and potential impact on serious comorbidities, such as asthma...
  81. ncbi Chronic idiopathic urticaria treatment
    J M Negro-Alvarez
    Allergy Section Virgen de la Arrixaca University Hospital Associated Professor of Allergy University of Murcia Murcia Spain
    Allergol Immunopathol (Madr) 29:129-32. 2001
    ..Preliminary reports suggest that desloratadine and anti-leukotrienes may be effective in treating some patients with chronic idiopathic urticaria...
  82. ncbi A comparison of the effect of diphenhydramine and desloratadine on vigilance and cognitive function during treatment of ragweed-induced allergic rhinitis
    Jeffrey A Wilken
    Department of Psychology, Veterans Affairs Medical Center, Washington, DC 20422, USA
    Ann Allergy Asthma Immunol 91:375-85. 2003
    ..Decrements in cognitive performance are associated with the use of sedating antihistamines. Most, but not all, second-generation antihistamines have been found to be nonsedating...
  83. ncbi Cost and resource utilization comparisons of second-generation antihistamines vs. montelukast for allergic rhinitis treatment
    Joel Hay
    University of Southern California, Los Angeles, California, USA
    Allergy Asthma Proc 30:634-42. 2009
    ..These differences persisted after adjustment for patient fixed effects, available confounders, and treatment propensity scores...
  84. ncbi A survey of emergency department management of acute urticaria in children
    Suzanne M Beno
    Division of Emergency Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Emerg Care 23:862-8. 2007
    ..To describe emergency department management of acute urticaria in children and to determine factors associated with management strategies and adherence to practice guidelines...
  85. ncbi Loratadine provides early symptom control in seasonal allergic rhinitis
    Harold B Kaiser
    Clinical Research Institute, Minneapolis, MN 55402, USA
    Allergy Asthma Proc 29:654-8. 2008
    ..05). Loratadine was significantly more effective than placebo for all time points (p < 0.001). Early, sustained symptom relief was seen with loratadine, suggesting that it may be more effective for treating SAR symptoms...
  86. ncbi Chronic urticaria--assessment and treatment
    Suran Fernando
    Department of Clinical Immunology, Royal North Shore Hospital, St Leonards, New South Wales
    Aust Fam Physician 39:135-8. 2010
    ..Chronic urticaria is a common condition encountered in general practice and a frequent source of referral to the clinical immunologist, allergist and dermatologist...
  87. ncbi Second-generation antihistamines: the OTC debate
    C S Sampey
    Rose Medical Center, Denver, CO 80220, USA
    J Am Pharm Assoc (Wash) 41:454-7. 2001
    ..To demonstrate that the safety profiles of second-generation antihistamines (SGAs) meet the criteria set by the Food and Drug Administration (FDA) for switching these products to over-the-counter (OTC) status...
  88. ncbi Urticaria: current opinions about etiology, diagnosis and therapy
    Torsten Zuberbier
    Department of Dermatology and Allergy, Allergie Centrum Charité, Charite Universitatsmedizin, Berlin, Germany
    Acta Derm Venereol 87:196-205. 2007
    ..g. allergic rhinitis. The current guidelines therefore suggest increasing the dosage up to four-fold, whereas alternative treatments should be reserved as add-on therapy for unresponsive patients...
  89. ncbi Mechanism responsible for epileptogenic activity by first-generation H1-antagonists in rats
    C Kamei
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, 700 8530, Okayama, Japan
    Brain Res 887:183-6. 2000
    ..These results clearly suggest that the epileptogenic activity of first-generation H1-antagonists is dependent upon a centrally acting histaminergic mechanism...
  90. ncbi Clinical advantages of dual activity in urticaria
    K Kontou-Fili
    Department of Allergology, Clinical Immunology, Laikon General District Hospital of Athens, Greece
    Allergy 55:28-33. 2000
    ..Mizolastine has also been shown to be an effective treatment for cold-induced urticaria, causing significant delay in the whealing response to the ice-cube test and also reducing the wheal diameter...
  91. ncbi Rapid anti-inflammatory action of azelastine eyedrops for ongoing allergic reactions
    Giorgio Ciprandi
    Allergy and Immunology Clinic, Department of Internal Medicine, Genoa University, Genoa, Italy
    Ann Allergy Asthma Immunol 90:434-8. 2003
    ..Some second-generation antihistamines have anti-inflammatory activities, but the clinical relevance of this property is still unclear...
  92. ncbi [New therapeutic strategies for the different subtypes of urticaria]
    U Raap
    Klinik und Poliklinik fur Dermatologie und Venerologie, Medizinische Hochschule Hannover, Hannover
    Hautarzt 55:361-6. 2004
    ..Since urticaria has a profound impact on quality of life, effective treatment is very important. We consider new therapeutic options based on our long-term experience in treating patients with urticaria...
  93. ncbi Special considerations in treatment of allergic rhinitis in the elderly: role of intranasal corticosteroids
    Raymond G Slavin
    Department of Internal Medicine, Division of Immunobiology, Section of Allergy and Clinical Immunology, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    Allergy Asthma Proc 31:179-84. 2010
    ..The diagnosis and management of AR in the elderly require approaches tailored to specific age-related factors. Based on the available evidence, intranasal corticosteroids offer the best option for the treatment of older patients with AR...
  94. ncbi Continuous versus on-demand pharmacotherapy of allergic rhinitis: evidence and practice
    Gert Laekeman
    Research Centre for Pharmaceutical Care and Pharmaco economics, Katholieke Universiteit Leuven, Onderwijs en Navorsing 2, Herestraat 49, Leuven, Belgium
    Respir Med 104:615-25. 2010
    ..With regard to the cost and cost-effectiveness implications of continuous therapy versus on-demand therapy, more studies are necessary before definitive conclusions may be made...
  95. ncbi Second-generation antihistamines in asthma therapy: is there a protective effect?
    Garry M Walsh
    Department of Medicine and Therapeutics, University of Aberdeen Medical School, IMS Building, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Am J Respir Med 1:27-34. 2002
    ..Finally, several well-conducted studies suggest that combination therapy with antihistamines and antileukotrienes may be as effective as corticosteroid use in patients with allergic asthma and seasonal allergic rhinitis...
  96. ncbi New insights into the second generation antihistamines
    G M Walsh
    Department of Medicine and Therapeutics, University of Aberdeen Medical School, Scotland
    Drugs 61:207-36. 2001
    ....
  97. ncbi Allergic rhinitis and school performance
    I Jauregui
    Servicio de Alergologia, Hospital de Basurto, Bilbao, Spain
    J Investig Allergol Clin Immunol 19:32-9. 2009
    ..Concrete studies of the impact of chromones, anticholinergic agents, antileukotrienes and immunotherapy upon school performance are lacking...
  98. pmc Histamine H1 receptor antagonist cetirizine impairs working memory processing speed, but not episodic memory
    P van Ruitenbeek
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands
    Br J Pharmacol 161:456-66. 2010
    ..The aim of the present study was to determine whether cetirizine can be used as a tool to model cognitive deficits associated with histaminergic hypofunction...
  99. ncbi Treatment of allergic rhinitis
    Denise K Sur
    University of California, Los Angeles, USA
    Am Fam Physician 81:1440-6. 2010
    ..Evidence does not support the use of mite-proof impermeable covers, air filtration systems, or delayed exposure to solid foods in infancy...
  100. ncbi Allergic rhinitis: treatment based on patient profiles
    Bruce M Prenner
    Allergy Associates Medical Group, San Diego, Calif 92120, USA
    Am J Med 119:230-7. 2006
    ..Additional therapeutic agents can then be added or substituted based on individual symptom response...
  101. ncbi Functional gastrointestinal disorders and mast cells: implications for therapy
    G Barbara
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Neurogastroenterol Motil 18:6-17. 2006
    ..g., second generation antihistamines, proteinase-activated receptor antagonists) may be useful pharmacological tools for these common disorders...

Research Grants10

  1. IMMUNOPATHOGENESIS OF ALLERGIC ASPERGILLOSIS
    RAYMOND SLAVIN; Fiscal Year: 2001
    ....
  2. IMMUNOPATHOGENESIS OF ALLERGIC ASPERGILLOSIS
    RAYMOND SLAVIN; Fiscal Year: 2003
    ..abstract_text> ..
  3. Naturally occurring T regulatory cells control airway hyperresponsiveness
    Erwin Gelfand; Fiscal Year: 2008
    ..abstract_text> ..
  4. HRQL Impact of Chronic Conditions and Comorbidity Burden
    Patrick Sullivan; Fiscal Year: 2006
    ..S. [unreadable] [unreadable]..
  5. MEKK2 Regulation of Mast Cell/T Cell Cytokine Production
    Erwin Gelfand; Fiscal Year: 2003
    ..The studies will also define MEKK2 and ERK5 as targets for drug discovery for the control of allergic inflammation. ..
  6. Regulation of the Cough Reflex
    Donald Bolser; Fiscal Year: 2006
    ..Furthermore, this project will test the proposed roles of medullary and spinal cellular elements that contribute to the generation and control of expiratory motor discharge during cough. ..
  7. FLT3-LIGAND, IMMUNOMODULATION AND THERAPY IN ASTHMA
    DEVENDRA AGRAWAL; Fiscal Year: 2008
    ..The long-term goal of this study is to better define the potential mechanisms of action of FL to prevent and reverse allergic airway inflammation and associated changes in pulmonary function. ..
  8. TGF-BETA, CHLORIDE CHANNELS AND APOPTOSIS OF AIRWAY EPITHELIAL CELLS
    Devendra K Agrawal; Fiscal Year: 2010
    ..Such investigations would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease. ..