histamine agonists

Summary

Summary: Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety of clinical applications histamine agonists have so far been more widely used in research than therapeutically.

Top Publications

  1. pmc Characterization of the histamine receptors in the guinea-pig lung: evidence for relaxant histamine H3 receptors in the trachea
    L O Cardell
    Department of Otorhinolaryngology, , Sweden
    Br J Pharmacol 111:445-54. 1994
  2. pmc Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors
    Eva Breunig
    Department of Human Biology, Technische Universitat Munchen, Hochfeldweg 2, Freising Weihenstephan, Germany
    J Physiol 583:731-42. 2007
  3. ncbi Phospholipase Cbeta 3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons
    Sang Kyou Han
    Division of Biology, 147 75, California Institute of Technology, Pasadena, California 91125, USA
    Neuron 52:691-703. 2006
  4. pmc H3 receptors and pain modulation: peripheral, spinal, and brain interactions
    Lindsay B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    J Pharmacol Exp Ther 336:30-7. 2011
  5. ncbi Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists
    Ruengwit Kitbunnadaj
    Leiden Amsterdam Center of Drug Research LACDR, Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    J Med Chem 46:5445-57. 2003
  6. ncbi A temporal analysis of the central neural processing of itch
    C E Kleyn
    The University of Manchester, Manchester Academic Health Science Centre, Manchester M6 8HD, UK
    Br J Dermatol 166:994-1001. 2012
  7. ncbi Activation of spinal histamine H3 receptors inhibits mechanical nociception
    Keri E Cannon
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Ave, Albany, NY 12206, USA
    Eur J Pharmacol 470:139-47. 2003
  8. ncbi Histamine H(3) receptor modulates nociception in a rat model of cholestasis
    Parisa Hasanein
    Bu Ali Sina University, School of Basic Sciences, Department of Biology, 65178 33391 Hamedan, Iran
    Pharmacol Biochem Behav 96:312-6. 2010
  9. ncbi Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice
    Víctor Fernández-Dueñas
    Unitat de Farmacologia, Departament Patologia i Terapèutica Experimental, Facultat de Medicina, Universitat de Barcelona, L Hospitalet de Llobregat, 08907 Barcelona, Spain
    Eur J Pharmacol 638:72-7. 2010
  10. pmc H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway
    Heather Francis
    Department of Research and Education, College of Medicine, Scott and White Hospital and The Texas A and M University System Health Science Center, Temple, TX 76504, USA
    Lab Invest 87:473-87. 2007

Detail Information

Publications230 found, 100 shown here

  1. pmc Characterization of the histamine receptors in the guinea-pig lung: evidence for relaxant histamine H3 receptors in the trachea
    L O Cardell
    Department of Otorhinolaryngology, , Sweden
    Br J Pharmacol 111:445-54. 1994
    ..A dilator H2 receptor on the smooth muscle cells seems, at least in vitro, to be the most potent mediator of histamine-mediated pulmonary arterial dilatation...
  2. pmc Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors
    Eva Breunig
    Department of Human Biology, Technische Universitat Munchen, Hochfeldweg 2, Freising Weihenstephan, Germany
    J Physiol 583:731-42. 2007
    ..These data may form the basis of identification of new targets to treat inflammatory and functional gut disorders...
  3. ncbi Phospholipase Cbeta 3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons
    Sang Kyou Han
    Division of Biology, 147 75, California Institute of Technology, Pasadena, California 91125, USA
    Neuron 52:691-703. 2006
    ..These results demonstrate that PLCbeta3 is required to mediate "itch" sensation in response to histamine acting on the histamine H1 receptor in C-fiber nociceptive neurons...
  4. pmc H3 receptors and pain modulation: peripheral, spinal, and brain interactions
    Lindsay B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    J Pharmacol Exp Ther 336:30-7. 2011
    ..Newer H(3) inverse agonists with potent, selective, and brain-penetrating properties show efficacy in several neuropathic and arthritis pain models, but the sites and mechanisms for these actions remain poorly understood...
  5. ncbi Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists
    Ruengwit Kitbunnadaj
    Leiden Amsterdam Center of Drug Research LACDR, Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    J Med Chem 46:5445-57. 2003
    ..Moreover, replacement of the piperidine ring of immepip by a pyrrolidine ring led to a pair of enantiomers that show a distinct stereoselectivity at the human H(3) and H(4) receptor...
  6. ncbi A temporal analysis of the central neural processing of itch
    C E Kleyn
    The University of Manchester, Manchester Academic Health Science Centre, Manchester M6 8HD, UK
    Br J Dermatol 166:994-1001. 2012
    ..Although it is known that itch induces activation of a neural network in the brain, the temporal dynamics of the network as well as the pathophysiology and neurobiology are not well understood...
  7. ncbi Activation of spinal histamine H3 receptors inhibits mechanical nociception
    Keri E Cannon
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Ave, Albany, NY 12206, USA
    Eur J Pharmacol 470:139-47. 2003
    ..e. mechanical vs. thermal) inhibition of nociception by these receptors, and to assess the efficacy of spinally delivered histamine H(3) receptor agonists for the treatment for pain...
  8. ncbi Histamine H(3) receptor modulates nociception in a rat model of cholestasis
    Parisa Hasanein
    Bu Ali Sina University, School of Basic Sciences, Department of Biology, 65178 33391 Hamedan, Iran
    Pharmacol Biochem Behav 96:312-6. 2010
    ..The present data show that the histamine H(3) receptor system may be involved in the regulation of nociception during cholestasis in rats...
  9. ncbi Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice
    Víctor Fernández-Dueñas
    Unitat de Farmacologia, Departament Patologia i Terapèutica Experimental, Facultat de Medicina, Universitat de Barcelona, L Hospitalet de Llobregat, 08907 Barcelona, Spain
    Eur J Pharmacol 638:72-7. 2010
    ..Overall, our results clearly show that R-(alpha)-methylhistamine enhances fentanyl effects at peripheral sites, and that the control of substance P levels might be one of the mechanisms responsible of such interaction...
  10. pmc H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway
    Heather Francis
    Department of Research and Education, College of Medicine, Scott and White Hospital and The Texas A and M University System Health Science Center, Temple, TX 76504, USA
    Lab Invest 87:473-87. 2007
    ..Downregulation of cAMP-dependent PKA/ERK1/2/Elk-1 phosphorylation (by activation of H3R) is important in the inhibition of cholangiocyte growth in liver diseases...
  11. pmc Histamine influences body temperature by acting at H1 and H3 receptors on distinct populations of preoptic neurons
    Ebba Gregorsson Lundius
    Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 30:4369-81. 2010
    ..Our data indicate that histamine modulates the core body temperature by acting at two distinct populations of preoptic neurons that express H1 and H3 receptor subtypes, respectively...
  12. ncbi Nalpha-methyl histamine safety and efficacy in migraine prophylaxis: phase III study
    Rebeca O Millan-Guerrero
    Department of Neurology, Unidad de Investigacion Medica en Epidemiologia Clinica, Hospital General de Zona UMF No 1 IMSS Colima
    Can J Neurol Sci 33:195-9. 2006
    ..The histamine catabolite, Nalpha-methylhistamine, possesses a selective affinity for H3 receptors. For this reason, we considered evaluating the efficacy of this histaminergic H3 agonist in migraine prophylactic treatment...
  13. pmc Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus
    Ryo Yoshimoto
    Tsukuba Research Institute, Banyu Pharmaceutical Company, Ltd, Tsukuba, Ibaraki 300 2611, Japan
    Proc Natl Acad Sci U S A 103:13866-71. 2006
    ..The results provide roles of H3Rs in energy homeostasis and suggest a therapeutic potential for H3R agonists in the treatment of obesity and diabetes mellitus...
  14. ncbi Histamine H3 receptors inhibit serotonin release in substantia nigra pars reticulata
    Sarah Threlfell
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, United Kingdom
    J Neurosci 24:8704-10. 2004
    ..The potent regulation of 5-HT by H3Rs reported here not only elucidates HA function in the SNr but also raises the possibility of novel targets for basal ganglia therapies...
  15. pmc Histamine H(2) receptors mediate the inhibitory effect of histamine on human eosinophil degranulation
    C I Ezeamuzie
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, P O Box 24923, Safat, Kuwait
    Br J Pharmacol 131:482-8. 2000
    ..These results suggest that histamine, via stimulation of H(2) receptors and a consequent elevation of intracellular levels of cyclic AMP, inhibits human eosinophil degranulation...
  16. ncbi Selective ligands as tools to study histamine receptors
    H van der Goot
    Leiden Amsterdam Center for Drug Research, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, NL 1081 HV, Amsterdam, The Netherlands
    Eur J Med Chem 35:5-20. 2000
    ..Most important radiolabelled H(3) antagonists are S-[3H]methylthioperamide, [3H]thioperamide, [125I]iodophenpropit and [125I]iodoproxyfan. The use of all these compounds as a tool in pharmacology is also discussed...
  17. ncbi Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937
    C Shayo
    Institute of Biology and Experimental Medicine, National Research Council of Argentina, Buenos Aires
    Mol Pharmacol 51:983-90. 1997
    ....
  18. ncbi The brain H3-receptor as a novel therapeutic target for vigilance and sleep-wake disorders
    R Parmentier
    INSERM U628, Department of Experimental Medicine, Faculty of Medicine, Claude Bernard University, 69373 Lyon, France
    Biochem Pharmacol 73:1157-71. 2007
    ....
  19. ncbi Molecular aspects of the histamine H3 receptor
    Gerold Bongers
    Leiden Amsterdam Center for Drug Research, Department of Medicinal Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    Biochem Pharmacol 73:1195-204. 2007
    ..In this paper, we review various molecular aspects of the hH(3)R including its signal transduction, dimerization and the occurrence of different H(3)R isoforms...
  20. ncbi Molecular and pharmacological characterization of the mouse histamine H3 receptor
    Jingcai Chen
    Johnson and Johnson Pharmaceutical Research and Development, 3210 Merryfield Row, San Diego, CA 92121, USA
    Eur J Pharmacol 467:57-65. 2003
    ..Taken together, these findings allow a further appreciation of the histamine H(3) receptor at the molecular level and provide an additional species to assist in the pharmacological assessment of histamine H(3) receptor function...
  21. ncbi Anti-inflammatory and antinociceptive properties of BP 2-94, a histamine H(3)-receptor agonist prodrug
    A Rouleau
    Unité de Neurobiologie et Pharmacologie Moléculaire U 109 de l Institut National de la Santé et de la Recherche Médicale, Centre Paul Broca, Paris, France
    J Pharmacol Exp Ther 295:219-25. 2000
    ..These observations with BP 2-94 suggest that H(3)-receptor agonists might represent a novel class of anti-inflammatory and antinociceptive agents...
  22. ncbi G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations
    Kathleen M Krueger
    Neurosciences Research, Abbott Laboratories, Global Pharmaceutical Research and Development, Abbott Park, IL 60064 6125, USA
    J Pharmacol Exp Ther 314:271-81. 2005
    ....
  23. ncbi Histamine inhibits chemotaxis, phagocytosis, superoxide anion production, and the production of TNFalpha and IL-12 by macrophages via H2-receptors
    Y Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Int Immunopharmacol 1:1867-75. 2001
    ..These results suggest that histamine and dimaprit may inhibit chemotaxis, phagocytosis, superoxide anion production, and the production of TNFalpha and IL-12 by macrophages via H2-histamine receptors. reserved...
  24. ncbi Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus
    Paul J Dunford
    Johnson and Johnson Pharmaceutical Research and Development, LLC, San Diego, CA 92121, USA
    J Allergy Clin Immunol 119:176-83. 2007
    ..The histamine H(4) receptor is a recently described histamine receptor, expressed on hematopoietic cells, linked to the pathology of allergy and asthma...
  25. ncbi Betahistine inhibits food intake in rats
    A Szelag
    Department of Pharmacology, , Poland
    Pol J Pharmacol 53:701-7. 2001
    ..Betahistine, administered intraperitoneally, decreased, in a dose-dependent manner and in a statistically significant degree, total food intake in different experimental models in rats...
  26. ncbi Effects of histamine H3 receptor agonist and antagonist on histamine co-transmitter expression in rat brain
    C Chotard
    Unité INSERM U109 de Neurobiologie et Pharmacologie Moléculaire, Centre Paul Broca, Paris, France
    J Neural Transm 109:293-306. 2002
    ..Furthermore, GAD-67 mRNA levels were not significantly modified by these treatments...
  27. ncbi Evidence for activation of histamine H3 autoreceptors during handling stress in the prefrontal cortex of the rat
    Ben H C Westerink
    Department of Biomonitoring and Sensoring, University Center for Pharmacy, University of Groningen, Groningen 9713AV, The Netherlands
    Synapse 43:238-43. 2002
    ..These results clearly illustrate the efficacy of the H3 autoreceptor in modulating stimulated histamine release during natural stimulatory conditions...
  28. ncbi Effect of thioperamide on modified forced swimming test-induced oxidative stress in mice
    Mohd Akhtar
    Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India
    Basic Clin Pharmacol Toxicol 97:218-21. 2005
    ..The antidepressant effect of thioperamide appears to be mediated via serotonergic and/or antioxidant mechanisms...
  29. pmc Histaminergic and glycinergic modulation of GABA release in the vestibular nuclei of normal and labyrinthectomised rats
    Filip Bergquist
    Centre for Integrative Physiology, School of Biomedical Laboratory Sciences, Edinburgh University Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    J Physiol 577:857-68. 2006
    ..During vestibular compensation, histaminergic modulation of glycine and GABA release may contribute to the rebalancing of neural activity in the vestibular nuclei of the lesioned and intact sides...
  30. ncbi Molecular cloning and characterization of a new human histamine receptor, HH4R
    T Nakamura
    Banyu Pharmaceutical Company, Ltd, Tsukuba Research Institute, Okubo 3, Tsukuba, Ibaraki, 300 2611, Japan
    Biochem Biophys Res Commun 279:615-20. 2000
    ..These observations indicate that the clone is a distinct histamine receptor from HH3R, and thus is named HH4R...
  31. ncbi The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes
    Kristoffer Sahlholm
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Eur J Pharmacol 567:206-10. 2007
    ....
  32. ncbi Cloning and characterization of a novel human histamine receptor
    K L Morse
    Department of Human Genomics Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Pharmacol Exp Ther 296:1058-66. 2001
    ..In both of these assays, SP9144 exhibited evidence of constitutive activation. Taken together, these data demonstrate that SP9144 is a unique, fourth histamine receptor subtype...
  33. ncbi Inhibitory effect of histamine on axonal transport in cultured mouse dorsal root ganglion neurons
    R Amano
    Department of Ophthalmology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara 228-8555, Japan
    Neurosci Res 41:201-6. 2001
    ..The H(2)-receptor antagonist cimetidine (1 microM) was ineffective. These results suggest that histamine inhibits axonal transport of cultured mouse DRG neurons via the activation of H(1)- and H(3)-receptors...
  34. ncbi Comparison of the binding distribution of agonist and antagonist ligands for histamine H3 receptors in pig brain by quantitative autoradiography
    Kelin Mezzomo
    Fundacao Faculdade Federal de Ciencias Medicas de Porto Alegre, Brazil
    Eur J Pharmacol 564:75-9. 2007
    ..e. those linked to intracellular G-protein, comprise a subset of the total receptor antagonist-binding sites in the basal ganglia, as has been reported for dopamine D(2) receptors...
  35. ncbi Activation of histamine H3 receptors inhibits renal noradrenergic neurotransmission in anesthetized dogs
    T Yamasaki
    Department of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan
    Am J Physiol Regul Integr Comp Physiol 280:R1450-6. 2001
    ..Thus functional histamine H3 receptors, possibly located on renal noradrenergic nerve endings, may play the role of inhibitory modulators of renal noradrenergic neurotransmission...
  36. ncbi Non-imidazole histamine NO-donor H3-antagonists
    Paolo Tosco
    Dipartimento di Scienza e Tecnologia del Farmaco, via P Giuria 9, I 10125 Torino, Italy
    Farmaco 60:507-12. 2005
    ....
  37. pmc Histamine H(3) receptor-mediated inhibition of depolarization-induced, dopamine D(1) receptor-dependent release of [(3)H]-gamma-aminobutryic acid from rat striatal slices
    J A Arias-Montaño
    Department of Physiology, Biophysics and Neurosciences, Centro de Investigacion y de Estudios Avanzados, Apartado Postal 14 740, Mexico, D F, Mexico
    Br J Pharmacol 133:165-71. 2001
    ..These observations demonstrate that histamine H(3) receptor activation strongly inhibits the dopamine D(1) receptor-dependent release of [(3)H]-GABA from rat striatum; primarily through an interaction at the terminals of GABA neurones...
  38. ncbi The H3 receptor is involved in cholecystokinin inhibition of food intake in rats
    S Attoub
    , , Paris, France
    Life Sci 69:469-78. 2001
    ..Our data suggest that the H3-receptor is involved in basal feeding. They also suggest that CCK satiety depends upon the release of histamine which acts on the H2- and H1-receptors, the final mediators of this effect...
  39. pmc Effects of N-alpha-methyl-histamine on human H(2) receptors expressed in CHO cells
    T Saitoh
    Department of Internal Medicine, Tokyo Women s Medical University Daini Hospital, 2 1 10 Nishiogu, Arakawa ku, Tokyo 116 8567, Japan
    Gut 50:786-9. 2002
    ..As H2Rs and H3Rs play different roles in gastric acid secretion, it is very important to verify that NAMH is a H2R agonist...
  40. ncbi BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology
    X Ligneau
    Bioprojet Biotech, Saint Grégoire, France
    J Pharmacol Exp Ther 320:365-75. 2007
    ..These preclinical data suggest that BF2.649 is a valuable drug candidate to be developed in wakefulness or memory deficits and other cognitive disorders...
  41. ncbi Role of histamine H3 receptors in control of mouse intestinal motility in vivo and in vitro: comparison with alpha2-adrenoceptors
    Cristina Pozzoli
    University of Parma, School of Medicine, Institute of Pharmacology, Italy
    Dig Dis Sci 47:1065-72. 2002
    ..Conversely, the presence of a2-adrenoceptors in the cholinergic nerve endings and their inhibitory role in the control of gastrointestinal propulsion is confirmed...
  42. pmc Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor
    Karen F Buckland
    Biomedical Sciences Division, Faculty of Medicine, Imperial College London, London SW7 2AZ
    Br J Pharmacol 140:1117-27. 2003
    ..6. This study demonstrates that human eosinophils express functional H4 receptors and may provide a novel target for allergic disease therapy...
  43. ncbi H3 receptor antagonists/inverse agonists as anti-obesity agents
    Arthur A Hancock
    Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6125, USA
    Curr Opin Investig Drugs 4:1190-7. 2003
    ..The in vitro and in vivo attributes of these compounds support the prospect that one of the new lead agents currently under preclinical investigation will have the properties required for clinical utility as an anti-obesity agent...
  44. ncbi Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor
    Sayaka Ito
    Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Tsukuba, Ibaraki 300 2611, Japan
    Eur J Pharmacol 529:40-6. 2006
    ..Thus, GT-2331 displayed the spectrum of pharmacological activities from full agonism to full antagonism, these observations suggest that histamine H(3) receptor ligands need to be carefully evaluated in various paradigms...
  45. ncbi Histamine (H3) receptors modulate the excitatory amino acid receptor response of the vestibular afferents
    Hortencia Chávez
    Instituto de Fisiología BUAP, Universidad Autonoma de Puebla, Apartado Postal 406, Puebla, Pue CP 72000, Mexico
    Brain Res 1064:1-9. 2005
    ..The present data show that the inhibitory action of the afferent neurons discharge previously described for BH is not restricted to this molecule but is also shared by other H3 antagonists...
  46. ncbi Meta-substituted aryl(thio)ethers as potent partial agonists (or antagonists) for the histamine H3 receptor lacking a nitrogen atom in the side chain
    Nadia Pelloux-Léon
    Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, England, UK
    J Med Chem 47:3264-74. 2004
    ....
  47. ncbi Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist
    Herman D Lim
    Leiden Amsterdam Center for Drug Research, Department of Medicinal Chemistry, Vrije Universiteit Amsterdam, The Netherlands
    J Pharmacol Exp Ther 314:1310-21. 2005
    ..8). The identification of 4-methylhistamine as a potent H(4)R agonist is of major importance for future studies to unravel the physiological roles of the H(4)R...
  48. ncbi Imidazole H3-antagonists: relationship between structure and ex vivo binding to rat brain H3-receptors
    Federica Vacondio
    Dipartimento Farmaceutico, Universita degli Studi di Parma, Parco Area delle Scienze 27A, I 43100 Parma, Italy
    Eur J Pharm Sci 23:89-98. 2004
    ..4) (apparent lipophilicity at pH 7.4) and DeltalogPoct-dce (a descriptor of H-bond donor capacity) allowed to model brain permeation of the majority of the compounds examined...
  49. ncbi Unexpected partial H1-receptor agonism of imidazole-type histamine H3-receptor antagonists lacking a basic side chain
    B Sadek
    Faculty of Pharmacy and Health Sciences, Ajman University of Science and Technology, Al Ain Campus, Al Ain, United Arab Emirates
    Inflamm Res 53:S109-15. 2004
    ..The putative partial H1-receptor agonism of some H3-receptor antagonists belonging to the proxifan series was characterized in a functional in-vitro assay using guinea-pig ileum...
  50. ncbi Dual role of histamine in modulation of Leydig cell steroidogenesis via HRH1 and HRH2 receptor subtypes
    Carolina Mondillo
    Lab of Molecular Endocrinology and Signal Transduction, Institute of Biology and Experimental Medicine CONICET, CP 1428, Buenos Aires, Argentina
    Biol Reprod 73:899-907. 2005
    ....
  51. ncbi Role of the histamine system in nefopam-induced antinociception in mice
    Philippe Girard
    Laboratoires Biocodex, Service de Pharmacologie, Zac de Mercières 60200 Compiègne, France
    Eur J Pharmacol 503:63-9. 2004
    ..In conclusion, nefopam analgesic activity is not mediated by histamine H1 or H2 receptors, but can be slightly modulated by histamine H3 receptors in mouse pain tests...
  52. ncbi Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells
    Ralf Gutzmer
    Department of Dermatology and Allergology, Hannover Medical University, Hannover, Germany
    J Immunol 174:5224-32. 2005
    ..Histamine induces chemotaxis and IL-12p70 suppression via different receptors using different signaling pathways, which might be important for the pathogenesis of and therapeutic interventions in allergic diseases...
  53. pmc Changes in the histaminergic system during vestibular compensation in the cat
    Brahim Tighilet
    UMR 6149 Neurobiologie Intégrative et Adaptative, Pôle 3C Comportement, Cerveau, Cognition, Centre de St Charles Case B, 3 Place Victor Hugo, 13331 Marseille Cedex 3, France
    J Physiol 573:723-39. 2006
    ..Indeed, spontaneous nystagmus, posture and locomotor balance were rapidly recovered in the UVN cats treated with thioperamide. These results demonstrate that changes in histamine levels are related to vestibular compensation...
  54. ncbi Waking selective neurons in the posterior hypothalamus and their response to histamine H3-receptor ligands: an electrophysiological study in freely moving cats
    G Vanni-Mercier
    INSERM U480, Departement de Medecine Experimentale, Universite Claude Bernard, 8, avenue Rockefeller, 69373 Lyon Cedex 08, France
    Behav Brain Res 144:227-41. 2003
    ....
  55. ncbi Endogenous histamine in the medial septum-diagonal band complex increases the release of acetylcholine from the hippocampus: a dual-probe microdialysis study in the freely moving rat
    Lucia Bacciottini
    Dipartimento di Farmacologia Preclinica e Clinica, Universita di Firenze, V le G Pieraccini 6, Italy
    Eur J Neurosci 15:1669-80. 2002
    ..These results indicate a role for endogenous histamine in modulating the cholinergic tone in the hippocampus...
  56. ncbi Betahistine dihydrochloride interaction with the histaminergic system in the cat: neurochemical and molecular mechanisms
    Brahim Tighilet
    UMR 6149 Neurobiologie Intégrative et Adaptative, Universite de Provence CNRS, 52 Faculté de Saint Jérôme Case 361, F 13397 Cedex 20, Marseille, France
    Eur J Pharmacol 446:63-73. 2002
    ..This action on the histaminergic system could explain the effectiveness of betahistine in the treatment of vertigo and vestibular disease...
  57. pmc Effects of histamine on the contractile and electrical activity in isolated lymphatic vessels of the guinea-pig mesentery
    James L R Fox
    Mucosal Inflammation and Smooth Muscle Research Groups, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Canada
    Br J Pharmacol 136:1210-8. 2002
    ..Correlation of these effects with histamine-induced changes in membrane potential and STD activity suggests the involvement of these electrical changes in the initiation of the contractile response...
  58. ncbi Activation of histaminergic H3 receptors in the rat basolateral amygdala improves expression of fear memory and enhances acetylcholine release
    Iacopo Cangioli
    Dipartimento di Farmacologia Preclinica e Clinica, V le G Pieraccini 6, Universita di Firenze, 50139 Firenze, Italy
    Eur J Neurosci 16:521-8. 2002
    ..Thus, our results further support a physiological role for synaptically released histamine, that in addition to affecting cholinergic transmission in the amygdala, modulates consolidation of fear memories..
  59. ncbi Stereochemical diversity-oriented conformational restriction strategy. Development of potent histamine H3 and/or H4 receptor antagonists with an imidazolylcyclopropane structure
    Mizuki Watanabe
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo 060 0812, Japan
    J Med Chem 49:5587-96. 2006
    ..These results show that when the structure of the target protein is unknown, the stereochemical diversity-oriented approach can be a powerful strategy in medicinal chemical studies...
  60. ncbi Antipsychotic-like profile of thioperamide, a selective H3-receptor antagonist in mice
    Mohd Akhtar
    Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, Hamdard University, New Delhi, India
    Fundam Clin Pharmacol 20:373-8. 2006
    ..Such effects of THP were reversed by RAMH indicating the involvement of histamine H(3)-receptors. Findings suggest a potential for H(3)-receptor antagonists in improving the refractory cases of schizophrenia...
  61. ncbi Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor
    Roland Seifert
    Department of Pharmacology and Toxicology, The University of Kansas, Malott Hall, Room 5064, 1251 Wescoe Hall Drive, Lawrence, KS 66045 7582, USA
    J Pharmacol Exp Ther 305:1104-15. 2003
    ....
  62. ncbi Histaminergic modulation of the intact respiratory network of adult mice
    M Dutschmann
    Georg August Universitat Gottingen, Institut für Neuro und Sinnesphysiologie, Humboldtallee 23, 37073 Gottingen, Germany
    Pflugers Arch 445:570-6. 2003
    ..The data indicate that histaminergic neuromodulation acts predominantly via H-1 receptors...
  63. ncbi Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway
    David Moreno-Delgado
    Universitat Autonoma de Barcelona, Neuroscience Institute and Department of Biochemistry and Molecular Biology, Bellaterra, Spain
    Neuropharmacology 51:517-23. 2006
    ..These results indicate that constitutive activity of H3 receptors in rat brain cortex inhibits the adenylate cyclase/PKA pathway, and perhaps also the opening of N-type voltage sensitive calcium channels, but apparently not CaMKII...
  64. pmc Detection of multiple H3 receptor affinity states utilizing [3H]A-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand
    David G Witte
    Neuroscience Research, Dept R4MN, Global Pharmaceutical Research Division, Abbott Laboratories, Bldg AP9A 2, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Br J Pharmacol 148:657-70. 2006
    ..3H]A-349821 competition studies showed significant differences in the proportions and potencies of high- and low-affinity sites across species, providing new information about the fundamental pharmacological nature of H3 receptors...
  65. ncbi Cultured smooth muscle cells of the human vesical sphincter are more sensitive to histamine than are detrusor smooth muscle cells
    Jochen Neuhaus
    Department of Urology, University of Leipzig, Leipzig, Germany
    Urology 67:1086-92. 2006
    ..To compare histamine receptor expression in cultured smooth muscle cells from the human detrusor and internal sphincter using receptor-specific agonists...
  66. ncbi Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease
    Shuo Wang Qiao
    Institute of Immunology, Rikshospitalet, University of Oslo, Oslo, Norway
    J Immunol 174:1657-63. 2005
    ..Interestingly, TG2 is able to hydrolyze the peptide-histamine conjugates when the concentrations of substrates are lowered, thereby releasing deamidated gluten peptides that are stimulatory to T cells...
  67. ncbi Inhibitory H3 receptors on sympathetic nerves of the pithed rat: activation by endogenous histamine and operation in spontaneously hypertensive rats
    G Godlewski
    Zaklad Farmakodynamiki, Akademia Medyczna, Bialystok, Poland
    Naunyn Schmiedebergs Arch Pharmacol 355:261-6. 1997
    ..Moreover, it demonstrates that these H3 receptors are probably activated by endogenous histamine and appear to be operative in hypertension...
  68. pmc H3-receptor regulation of vascular gastrin and somatostatin releases by the isolated rat stomach
    A Bado
    , , , Paris, France
    Yale J Biol Med 67:113-21. 1994
    ..However, the reversal effect of (R)alpha-MeHA was prevented by the CCKB/gastrin receptor antagonist PD134308. These results support H3-receptor regulation of basal and cholinergically-stimulated GR and SR...
  69. ncbi Histamine H3 receptors regulate vascular permeability changes in the skin of mast cell-deficient mice
    Maria Alejandra Hossen
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima naka 1 1 1, 700 8530, Okayama, Japan
    Int Immunopharmacol 3:1563-8. 2003
    ..In addition, histamine and, to a lesser extent substance P are involved in the reaction...
  70. pmc Effects of histamine H1-, H2- and H3-receptor selective drugs on the mechanical activity of guinea-pig small and large intestine
    R Leurs
    Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, Amsterdam, The Netherlands
    Br J Pharmacol 102:179-85. 1991
    ..H2-receptors, causing smooth muscle relaxation appear not to be present in our preparations. At high concentrations of H2-receptor agents (agonists and antagonists) relaxations might be observed, due to unknown nonspecific effects...
  71. pmc Role of histamine in rodent antinociception
    P Malmberg Aiello
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    Br J Pharmacol 111:1269-79. 1994
    ..Involvement of the histaminergic system in the modulation of nociceptive stimuli is thus proposed...
  72. pmc Characterization of histamine-H3 receptors controlling non-adrenergic non-cholinergic contractions of the guinea-pig isolated ileum
    S J Taylor
    Department of Neuropharmacology, Glaxo Group Research, Ware, Herts
    Br J Pharmacol 105:667-74. 1992
    ..In addition we have identified N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline as an irreversible antagonist at H3 receptors and have used this compound to estimate apparent affinity values of agonists at H3 receptors in this preparation...
  73. pmc Autoregulation of enterochromaffin-like cell histamine secretion via the histamine 3 receptor subtype
    M Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520-8062, USA
    Yale J Biol Med 69:9-19. 1996
    ..Our observations support the proposal that a histamine-mediated short-loop autocrine regulatory mechanism of ECL cell secretion exists...
  74. ncbi Effects of histamine and betahistine on rat medial vestibular nucleus neurones: possible mechanism of action of anti-histaminergic drugs in vertigo and motion sickness
    J J Wang
    Department of Physiology, Medical School, Edinburgh, UK
    Exp Brain Res 105:18-24. 1995
    ....
  75. ncbi Neutrophil adhesion to histamine stimulated cultured endothelial cells is primarily mediated via activation of phospholipase C and nitric oxide synthase isozymes
    U Schaefer
    Department of Surgery, University of Cologne, Germany
    Inflamm Res 47:256-64. 1998
    ....
  76. pmc Pharmacological characterization of the human histamine H2 receptor stably expressed in Chinese hamster ovary cells
    R Leurs
    Leiden Amsterdam Center for Drug Research, Department of Pharmacochemistry, Vrije Universiteit, The Netherlands
    Br J Pharmacol 112:847-54. 1994
    ..This receptor is functionally coupled to the adenylate cyclase in CHO cells, but does not influence the inositolphosphate turnover or arachidonic acid release...
  77. ncbi Presynaptic inhibition produced by histamine at nicotinic synapses in enteric ganglia
    K Tamura
    Department of Physiology, College of Medicine, Ohio State University, Columbus 43210
    Neuroscience 25:171-9. 1988
    ..Burimamide, a histamine antagonist with higher activity at putative H3 receptors than H2 receptors, effectively reversed the inhibitory action of histamine on the excitatory postsynaptic potentials.(ABSTRACT TRUNCATED AT 250 WORDS)..
  78. ncbi Histamine H1 and H2 receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment
    Y Ashida
    Skin Biology Research Laboratories, Life Science Research Center, Shiseido Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    J Invest Dermatol 116:261-5. 2001
    ..In conclusion, both the histamine H1 and H2 receptors in the epidermis are involved in skin barrier function and the cutaneous condition of epidermal hyperplasia...
  79. ncbi Histamine induced elevation of cyclic AMP phosphodiesterase activity in human monocytes
    C A Holden
    Department of Dermatology, St Helier Hospital, Carshalton, Surrey, England
    Agents Actions 22:36-42. 1987
    ..e. increased catabolism and a net reduction in cAMP levels. The localization of this effect predominantly to monocytes indicates a potentially important mechanism for histamine action on immune regulation...
  80. ncbi Mucosal protective action of histamine against gastric lesions induced by HCl in rats: importance of antigastric motor activity mediated by H2-receptors
    K Takeuchi
    Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan
    J Pharmacol Exp Ther 245:632-8. 1988
    ....
  81. pmc Histamine H1-receptor-mediated inositol phospholipid hydrolysis in DDT1MF-2 cells: agonist and antagonist properties
    T E White
    Department of Physiology and Pharmacology, Medical School, Queen s Medical Centre, Nottingham
    Br J Pharmacol 108:196-203. 1993
    ..Furthermore, the results also suggest that histamine HI- and adenosine A,-receptors activate phospholipase C in DDTMF-2 cells via two different G-protein-coupled pathways...
  82. pmc Characterization of histamine receptor sub-types regulating prostacyclin release from human endothelial cells
    H A Bull
    Department of Dermatology, University College and Middlesex School of Medicine, London
    Br J Pharmacol 107:276-81. 1992
    ..9. These results indicate that PGI2 from HUVEC is initiated and maintained via histamine HI-receptor occupancy. There appears to be no involvement of either H2- or H3-receptors in this particular endothelial cell histaminergic response...
  83. ncbi H1 and H2 histamine receptor participation in the brain control of prolactin secretion in lactating rats
    M C Arakelian
    Laboratorio de Neuroendocrinologia, Instituto de Biologia y Medicina Experimental, Buenos Aires, Argentina
    Endocrinology 100:890-5. 1977
    ..H1 receptors seem to be related to a facilitatory mechanism since classical antihistamines suppress the serum prolactin increase that follows the onset of suckling, while histamine itself is able to release prolactin in NSM...
  84. ncbi Protein phosphorylation in bovine adrenal medullary chromaffin cells: histamine-stimulated phosphorylation of tyrosine hydroxylase
    S J Bunn
    Neuroscience Group, Faculty of Medicine, University of Newcastle, New South Wales, Australia
    J Neurochem 59:164-74. 1992
    ..The mechanism or mechanisms whereby histamine modulates TOH phosphorylation are discussed with emphasis on the differences from depolarizing agents...
  85. ncbi Histamine activates phosphorylase and inositol phosphate production in guinea pig hepatocytes
    J A Garcia-Sainz
    Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, D F, Mexico
    Eur J Pharmacol 227:325-31. 1992
    ..These receptors are coupled to the phosphoinositide turnover-calcium mobilization signalling pathway through a pertussis toxin-insensitive process...
  86. ncbi Pharmacologic characterization of a novel histamine receptor on human eosinophils
    D G Raible
    Division of Allergy, Critical Care and Pulmonary Medicine, Hahnemann University School of Medicine, Philadelphia, Pennsylvania 19102 1192
    Am J Respir Crit Care Med 149:1506-11. 1994
    ..abstract truncated at 250 words)..
  87. pmc Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, [125I]-iodophenpropit, to rat brain
    F P Jansen
    Leiden Amsterdam Center for Drug Research, Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, The Netherlands
    Br J Pharmacol 113:355-62. 1994
    ..Histamine H3-receptor binding; radiolabelled H3-receptor antagonist; [125I]-iodophenpropit; rat cerebral cortex membranes; high affinity; guanine nucleotide shift; G-protein; autoradiography; distribution, histamine H3-receptor subtypes..
  88. ncbi Characterization of histamine receptors in the ureter of the dog
    R C Dodel
    Institute of Pharmacology, Heinrich Heine University Dusseldorf, Germany
    Eur J Pharmacol 318:395-402. 1996
    ....
  89. ncbi H2 histaminergic control of inhibition of eating induced by intragastric NaCl in rats
    F S Kraly
    Department of Psychology, Colgate University, Hamilton, NY 13346, USA
    Physiol Behav 65:105-13. 1998
    ..g. hypertonic NaCl. These results demonstrate that different subtypes of peripheral and/or central histamine receptors contribute to different behavioral consequences of postprandial gastrointestinal osmotic loads in rats...
  90. pmc Plasticity of histamine H3 receptor expression and binding in the vestibular nuclei after labyrinthectomy in rat
    Adrian F Lozada
    Department of Biology, Abo Akademi University, BioCity, Artillerigatan 6A, FIN 20520 Turku, Finland
    BMC Neurosci 5:32. 2004
    ....
  91. ncbi Characterization of histamine H2-receptors in human neutrophils with a series of guanidine analogues of impromidine. Are cell type-specific H2-receptors involved in the regulation of NADPH oxidase?
    R Burde
    Institut fur Pharmakologie, Freie Universitat Berlin
    Naunyn Schmiedebergs Arch Pharmacol 341:455-61. 1990
    ..In the latter system, guanidines are full H2-agonists with potencies of up to 125-fold of that of histamine. Our data indicate that guanidines inhibit O2- formation in human neutrophils via H2-receptors.(ABSTRACT TRUNCATED AT 250 WORDS)..
  92. ncbi Histaminergic neurons modulate acetylcholine release in the ventral striatum: role of H3 histamine receptors
    H Prast
    Institut für Pharmakologie und Toxikologie der Universität Innsbruck, Austria
    Naunyn Schmiedebergs Arch Pharmacol 360:558-64. 1999
    ..A dopamine-independent way seems also to be involved in the histamine-evoked acetylcholine release...
  93. ncbi Studies on the cardiovascular actions of central histamine H1 and H2 receptors
    J J Poulakos
    Department of Pharmacology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark
    J Pharmacol Exp Ther 250:500-7. 1989
    ..The finding that IMP is less potent in the central nervous system, compared to its known greater potency in the periphery, suggests that peripheral and central H2 receptors may be pharmacologically distinct...
  94. ncbi Atrial natriuretic factor negatively modulates secretin intracellular signaling in the exocrine pancreas
    Maria E Sabbatini
    Cátedras de Fisiopatología, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina
    Am J Physiol Gastrointest Liver Physiol 292:G349-57. 2007
    ..Present findings suggest that ANF may play a protective role by reducing secretin response to avoid overstimulation...
  95. ncbi Functional and binding characteristics of long-acting beta 2-agonists in lung and heart
    F J Roux
    John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Am J Respir Crit Care Med 153:1489-95. 1996
    ..7 +/- 0.04, respectively). Albuterol (5.83 +/- 0.06 and 4.71 +/- 0.16) and fenoterol (6.33 +/- 0.07 and 5.67 +/- 0.05) were less selective. These results can explain the potencies and efficacies of salmeterol and formoterol in humans...
  96. ncbi Direct myocardial effects of the thromboxane A2/prostaglandin H2 agonists U-46619 and SQ 26,655 under ischemic and nonischemic conditions
    G J Grover
    Department of Pharmacology, Squibb Institute for Medical Research, Princeton, N J
    Pharmacology 41:1-15. 1990
    ..In conclusion, TP antagonists are not cardioprotective in this model, but exogenous TP receptor agonists have complex actions in buffer-perfused hearts, some of which are mediated by vascular TP receptors and others which are not...
  97. ncbi Synthesis and in vitro pharmacology of arpromidine and related phenyl(pyridylalkyl)guanidines, a potential new class of positive inotropic drugs
    A Buschauer
    Institute of Pharmacy, Freie Universitat Berlin, Federal Republic of Germany
    J Med Chem 32:1963-70. 1989
    ..The rank order of potency in the atrium was in good agreement with the positive inotropic effects found in isolated, perfused guinea pig hearts, where 63-65 were the most potent compounds as well...
  98. ncbi Histamine receptors influence blood-spinal cord barrier permeability, edema formation, and spinal cord blood flow following trauma to the rat spinal cord
    H S Sharma
    Department of Surgical Sciences, Anesthesiology and Intensive Care, University Hospital, Uppsala University, Uppsala, Sweden
    Acta Neurochir Suppl 96:316-21. 2006
    ..p.) exacerbated spinal cord pathology. These observations suggest that stimulation of histamine H3 receptors and blockade of histamine H2 receptors is neuroprotective in SCI...
  99. ncbi Identification of two H3-histamine receptor subtypes
    R E West
    Department of Allergy and Immunology, Schering Plough Research, Bloomfield, New Jersey 07003
    Mol Pharmacol 38:610-3. 1990
    ..The distinction between H3A and H3B receptor subtypes, the former a high affinity and the latter a low affinity thioperamide site, draws support from published in vitro data...
  100. ncbi Histamine excites rat lateral vestibular nuclear neurons through activation of post-synaptic H2 receptors
    Jun Zhang
    Department of Biological Science and Technology and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Mailbox 426, Nanjing University, 22 Hankou Road, Nanjing 210093, China
    Neurosci Lett 448:15-9. 2008
    ....
  101. ncbi Effects of selected histamine H3 receptor antagonists on tele-methylhistamine levels in rat cerebral cortex
    S L Yates
    Gliatech Inc, Cleveland, OH 44122, USA
    Biochem Pharmacol 57:1059-66. 1999
    ..Thus, H3 receptor antagonists may differentially affect HA release and turnover, and brain t-MH levels may not be reliable predictors of H3 agonist, partial agonist, or antagonist in vivo activity...

Research Grants11

  1. Exercise, histamine receptors, and vascular function
    Steven A Romero; Fiscal Year: 2012
    ..Possible histamine agonists that have been identified include: 1) carnosine released or leaked from skeletal muscle 2) histamine release ..
  2. Betahistine: Novel Therapeutic in Attention Deficit Hyperactivity Disorder
    CHARLES PIERCE; Fiscal Year: 2009
    ..This Phase 1 SBIR proposal will determine the safety, tolerability, and pharmacokinetics of higher doses of betahistine and characterize dose-response for improving attention and impulsivity in young adults with ADHD. ..
  3. DEVELOPMENT OF NOVEL CHIRAL CYCLIC HISTAMINE H3 AGONISTS
    James Phillips; Fiscal Year: 1999
    ..PROPOSED COMMERCIAL APPLICATIONS: A selective HA H3 agonist, GT-2203, has been identified. These studies would further establish the use and safety of the H3 agonist and provide for development. ..
  4. BRAIN PEPTIDES--CENTRAL CONTROL OF GLUCOSE HOMEOSTASIS
    MARK GUNION; Fiscal Year: 1991
    ....
  5. AGONIST GATING OF NON-DESENSITIZING AMPA RECEPTORS
    MARK FLECK; Fiscal Year: 2004
    ....
  6. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2009
    ..abstract_text> ..
  7. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2006
    ..These experiments will help to discover the mechanism of action of this novel class of agents, and lead to the development of new pharmacotherapies for pain. ..
  8. Ang II and Norepinephrine in Cardiac Sympathetic Nerves
    Roberto Levi; Fiscal Year: 2009
    ..abstract_text> ..
  9. MOLECULAR MECHANISMS OF RETINA-SPECIFIC GENE EXPRESSION
    Peter Hitchcock; Fiscal Year: 2008
    ..A better understanding of transcriptional regulatory pathways may allow us to experimentally manipulate the expression of specific target gene(s) to correct a disease phenotype. [unreadable] [unreadable] [unreadable]..
  10. Early Stage Training in the Neurosciences
    Peter Hitchcock; Fiscal Year: 2005
    ..During the second year students take elective neuroscience courses, participate in an intensive neuroscience seminar course, complete their lab rotations and begin the initial work on the doctoral thesis. ..