glycine agents

Summary

Summary: Substances used for their pharmacological actions on glycinergic systems. Glycinergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function.

Top Publications

  1. ncbi Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator
    Brett A Graham
    School of Biomedical Sciences, Faculty of Health and Hunter Medical Research Institute, The University of Newcastle, Callaghan, New South Wales 2308, Australia
    J Neurosci 26:4880-90. 2006
  2. pmc Excitatory interneurons dominate sensory processing in the spinal substantia gelatinosa of rat
    Sónia F A Santos
    Instituto de Biologia Molecular e Celular IBMC, Universidade do Porto, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    J Physiol 581:241-54. 2007
  3. pmc Agonist action of taurine on glycine receptors in rat supraoptic magnocellular neurones: possible role in osmoregulation
    N Hussy
    CNRS UPR 9055, Montpellier, France
    J Physiol 502:609-21. 1997
  4. ncbi Changes on the properties of glycine receptors during neuronal development
    Luis G Aguayo
    Laboratory of Neurophysiology, Department of Physiology, University of Concepcion, P O Box 160 C, Concepcion, Chile
    Brain Res Brain Res Rev 47:33-45. 2004
  5. ncbi Cardiovascular response to a group III mGluR agonist in NTS requires NMDA receptors
    Patrick J Mueller
    Department of Biomedical Sciences, Dalton Cardiovascular Research Center, 134 Research Park, University of Missouri, Columbia, MO 65211 3300, USA
    Am J Physiol Regul Integr Comp Physiol 289:R198-208. 2005
  6. ncbi Glycine receptor-mediated inhibition of dopamine and non-dopamine neurons of the rat ventral tegmental area in vitro
    F Zheng
    Department of Physiology and Pharmacology, L-334, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
    Brain Res 919:313-7. 2001
  7. ncbi Three types of inhibitory miniature potentials in frog spinal cord motoneurons: possible GABA and glycine cotransmission
    Yu A Polina
    Karelia State Pedagogical University, Petrozavodsk, Russia
    Neurosci Behav Physiol 37:271-6. 2007
  8. ncbi Contributions of NMDA receptors to network recruitment and rhythm generation in spinal cord cultures
    Jean Christophe Legrand
    Department of Physiology, University of Bern, Buhlplatz 5, CH 3012 Bern, Switzerland
    Eur J Neurosci 19:521-32. 2004
  9. ncbi Intracuneate mechanisms underlying primary afferent cutaneous processing in anaesthetized cats
    Cristina Soto
    Department of Physiology, Faculty of Medicine, 15706 Santiago de Compostela, Spain
    Eur J Neurosci 19:3006-16. 2004
  10. ncbi Pharmacological characterization of glycine-gated chloride currents recorded in rat hippocampal slices
    Siriporn C Chattipakorn
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294, USA
    J Neurophysiol 87:1515-25. 2002

Research Grants

Detail Information

Publications173 found, 100 shown here

  1. ncbi Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator
    Brett A Graham
    School of Biomedical Sciences, Faculty of Health and Hunter Medical Research Institute, The University of Newcastle, Callaghan, New South Wales 2308, Australia
    J Neurosci 26:4880-90. 2006
    ..Together, these findings show the three mutations disrupt GlyR-mediated inhibition via different physiological mechanisms, and the spastic mutation results in "compensatory" alpha1 homomeric GlyRs at extrasynaptic loci...
  2. pmc Excitatory interneurons dominate sensory processing in the spinal substantia gelatinosa of rat
    Sónia F A Santos
    Instituto de Biologia Molecular e Celular IBMC, Universidade do Porto, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    J Physiol 581:241-54. 2007
    ..We conclude that sensory integration in the intrinsic SG neuronal network is dominated by excitatory interneurons. Such organization of neuronal circuitries in the spinal SG can be important for nociceptive encoding...
  3. pmc Agonist action of taurine on glycine receptors in rat supraoptic magnocellular neurones: possible role in osmoregulation
    N Hussy
    CNRS UPR 9055, Montpellier, France
    J Physiol 502:609-21. 1997
    ....
  4. ncbi Changes on the properties of glycine receptors during neuronal development
    Luis G Aguayo
    Laboratory of Neurophysiology, Department of Physiology, University of Concepcion, P O Box 160 C, Concepcion, Chile
    Brain Res Brain Res Rev 47:33-45. 2004
    ..Finally, the high level of plasticity found in immature GlyRs is likely associated to changes in cytoskeleton dynamics...
  5. ncbi Cardiovascular response to a group III mGluR agonist in NTS requires NMDA receptors
    Patrick J Mueller
    Department of Biomedical Sciences, Dalton Cardiovascular Research Center, 134 Research Park, University of Missouri, Columbia, MO 65211 3300, USA
    Am J Physiol Regul Integr Comp Physiol 289:R198-208. 2005
    ..Thus we conclude that responses to L-AP4 in the NTS are mediated by an interaction between group III mGluRs and NMDA receptors. Finally, we also caution that nonselective actions of L-AP4 should be considered in future studies...
  6. ncbi Glycine receptor-mediated inhibition of dopamine and non-dopamine neurons of the rat ventral tegmental area in vitro
    F Zheng
    Department of Physiology and Pharmacology, L-334, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
    Brain Res 919:313-7. 2001
    ..Our data also raise the possibility that glycine could increase dopamine output from the VTA by a mechanism of disinhibition...
  7. ncbi Three types of inhibitory miniature potentials in frog spinal cord motoneurons: possible GABA and glycine cotransmission
    Yu A Polina
    Karelia State Pedagogical University, Petrozavodsk, Russia
    Neurosci Behav Physiol 37:271-6. 2007
    ..These data suggest that frog spinal cord motoneurons have three types of inhibitory mIPSP, mediated by GABA, glycine, and simultaneous release of these two transmitters from the same presynaptic terminals...
  8. ncbi Contributions of NMDA receptors to network recruitment and rhythm generation in spinal cord cultures
    Jean Christophe Legrand
    Department of Physiology, University of Bern, Buhlplatz 5, CH 3012 Bern, Switzerland
    Eur J Neurosci 19:521-32. 2004
    ..We conclude that NMDA-R contribute to rhythm generation in spinal cultures by supporting recurrent excitation and network recruitment and by depolarizing the network...
  9. ncbi Intracuneate mechanisms underlying primary afferent cutaneous processing in anaesthetized cats
    Cristina Soto
    Department of Physiology, Faculty of Medicine, 15706 Santiago de Compostela, Spain
    Eur J Neurosci 19:3006-16. 2004
    ....
  10. ncbi Pharmacological characterization of glycine-gated chloride currents recorded in rat hippocampal slices
    Siriporn C Chattipakorn
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294, USA
    J Neurophysiol 87:1515-25. 2002
    ..Furthermore, our data suggest that at least two GlyR subtypes are present in hippocampus and that GlyR-mediated currents can be potentiated by zinc at concentrations that suppress glutamate-mediated excitability...
  11. ncbi Developmental shift in bidirectional functions of taurine-sensitive chloride channels during cortical circuit formation in postnatal mouse brain
    Mika Yoshida
    Department of Integrated Biosciences, University of Tokyo, Bioscience Bldg 402, Kashiwa, Chiba 277 8562, Japan
    J Neurobiol 60:166-75. 2004
    ..As cortical circuit has to be regulated in the later stages, taurine would serve as a safeguard against hyperexcitable circuit...
  12. ncbi Propofol and sevoflurane depress spinal neurons in vitro via different molecular targets
    Christian Grasshoff
    Section of Experimental Anesthesiology, Department of Anesthesiology, University of Tuebingen, Germany
    Anesthesiology 101:1167-76. 2004
    ..The relevant molecular targets of the commonly used volatile anesthetic sevoflurane in the spinal cord are largely unknown, but indirect evidence suggests a mechanism of action distinct from propofol...
  13. ncbi Alpha-adrenoreceptor activation modulates swimming via glycinergic and GABAergic inhibitory pathways in Xenopus laevis tadpoles
    Simon D Merrywest
    School of Biology, Division of Biomedical Sciences, Bute Medical Buildings, University of St Andrews, St Andrews, Fife KY16 9TS, Scotland
    Eur J Neurosci 15:375-83. 2002
    ....
  14. pmc Differential agonist sensitivity of glycine receptor alpha2 subunit splice variants
    Paul S Miller
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT
    Br J Pharmacol 143:19-26. 2004
    ....
  15. ncbi Distinct subtypes of group I metabotropic glutamate receptors on rat spinal neurons mediate complex facilitatory and inhibitory effects
    Cristina Marchetti
    Biophysics Sector and Istituto Nazionale di Fisica della Materia Unit, International School for Advanced Studies SISSA, Via Beirut 4, 34014 Trieste, Italy
    Eur J Neurosci 18:1873-83. 2003
    ....
  16. ncbi State-related inhibition by GABA and glycine of transmission in Clarke's column
    Niwat Taepavarapruk
    Faculty of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, The University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    J Neurosci 22:5777-88. 2002
    ..We conclude that GABA and GLY mediate behavioral state-specific inhibition of ascending sensory transmission via Clarke's column DSCT neurons...
  17. ncbi Inactivation of amino acid receptors in medullary reticular formation modulates and suppresses ingestion and rejection responses in the awake rat
    Zhixiong Chen
    Ohio State Univ, 305 W 12th Ave, PO Box 182357, Columbus, OH 43218 2357, USA
    Am J Physiol Regul Integr Comp Physiol 285:R68-83. 2003
    ..Release of this inhibition may be one mechanism by which aversive oral stimuli produce large-amplitude mouth openings associated with the rejection response...
  18. ncbi GABA-mediated inhibition of glutamate release during ischemia in substantia gelatinosa of the adult rat
    Noriaki Matsumoto
    Department of Physiology, Saga Medical School, Japan
    J Neurophysiol 89:257-64. 2003
    ..This action might protect SG neurons from an excessive excitation mediated by L-glutamate during ischemia...
  19. ncbi Nicotinic receptors regulate the release of glycine onto lamina X neurones of the rat spinal cord
    A Bradaia
    Laboratoire de Neurophysiologie Cellulaire et Intégrée, UMR 7519 CNRS ULP, 21 rue R Descartes, 67084 Strasbourg Cedex, France
    Neuropharmacology 43:1044-54. 2002
    ..These data demonstrate that neurones surrounding the central canal of the spinal cord present a glycinergic synaptic transmission which is modulated by terminal nAChRs...
  20. ncbi Long-lasting enhancement of corticostriatal neurotransmission by taurine
    A N Chepkova
    Brain Research Institute, Russian Academy of Medical Sciences, Moscow 103064, Russia
    Eur J Neurosci 16:1523-30. 2002
    ..LLETAU was significantly smaller in juvenile than in mature rodents. Activation of GlyRs and the specific taurine transporter by taurine evoke a long-lasting enhancement of corticostriatal transmission...
  21. pmc Role of inhibitory amino acids in control of hypoglossal motor outflow to genioglossus muscle in naturally sleeping rats
    Janna L Morrison
    Departments of Medicine and Physiology, University of Toronto, Toronto, Canada M5S 1A8
    J Physiol 552:975-91. 2003
    ....
  22. ncbi Involvement of the GABAergic system for Ptychodiscus brevis toxin-induced depression of synaptic transmission elicited in isolated spinal cord from neonatal rats
    Jitendra N Singh
    Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India
    Brain Res 974:243-8. 2003
    ..The results indicate that PbTx depressed the spinal reflexes via GABA(A) receptors. Furthermore, the potentiation of GABAergic action by PbTx requires the N-methyl-D-aspartate dependent mechanism...
  23. ncbi The actions of propofol on gamma-aminobutyric acid-A and glycine receptors in acutely dissociated spinal dorsal horn neurons of the rat
    Xian Ping Dong
    Laboratory of Receptor Pharmacology, Department of Neurobiology and Biophysics, University of Science and Technology of China, Hefei, People s Republic of China
    Anesth Analg 95:907-14, table of contents. 2002
    ..The results suggest that propofol facilitation of GABA(A)R and GlyR at the spinal level could contribute significantly to general anesthetic-induced analgesia and anesthesia...
  24. ncbi Neurogenesis of gasping does not require inhibitory transmission using GABA(A) or glycine receptors
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03755, USA
    Respir Physiol Neurobiol 132:265-77. 2002
    ..We conclude that the neurogenesis of gasping is not dependent upon fast, chloride-mediated inhibitory synaptic transmission...
  25. ncbi Beta-alanine acts on glycine receptors in the rat sacral dorsal commissural neurons
    Dian Shi Wang
    Department of Anatomy and K K Leung Brain Research Centre, Fourth Military Medical University, 17 West Changle Road, Xi an, 710032, Shaanxi, China
    Int J Neurosci 113:293-305. 2003
    ..The results indicate that beta-ALA activates the strychnine-sensitive glycine receptors in the SDCN neurons, and suggest that beta-ALA may act as a functional neurotransmitter in the mammalian SDCN...
  26. pmc GABAA and glycine receptors in regulation of intercostal and abdominal expiratory activity in vitro in neonatal rat
    Makito Iizuka
    Centre for Medical Sciences, Ibaraki Prefectural University of Health Sciences, 4669 2 Ami, Ibaraki 300 0394, Japan
    J Physiol 551:617-33. 2003
    ....
  27. ncbi Endogenous acetylcholine and nicotine activation enhances GABAergic and glycinergic inputs to cardiac vagal neurons
    Jijiang Wang
    Department of Pharmacology, George Washington University, Washington, DC 20037, USA
    J Neurophysiol 89:2473-81. 2003
    ..Nicotinic facilitation of inhibitory neurotransmission to premotor cardiac parasympathetic neurons may be involved in generating respiratory sinus arrhythmia...
  28. ncbi Characterization of the spontaneous synaptic activity of amacrine cells in the mouse retina
    M J Frech
    , Neuroanatomische Abteilung, D-60528 Frankfurt am Main, Germany
    J Neurophysiol 86:1632-43. 2001
    ..These differences in the activation and decay kinetics of sIPSCs indicate that amacrine cells of the mouse retina express at least three types of functionally different inhibitory receptors: GlyRs and possibly two subtypes of GABA(A)Rs...
  29. ncbi Characterization of inhibitory postsynaptic currents in rod bipolar cells of the mouse retina
    Moritz J Frech
    Max Planck Institut für Hirnforschung, Neuroanatomical Department, Frankfurt am Main, Germany
    Vis Neurosci 21:645-52. 2004
    ....
  30. ncbi Chloride homeostasis differentially affects GABA(A) receptor- and glycine receptor-mediated effects on spontaneous circuit activity in hippocampal cell culture
    Wei Wang
    Department of Neurobiology and Biophysics, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
    Neurosci Lett 406:11-6. 2006
    ..Our findings suggest that KCC2-dependent chloride homeostasis is mainly involved in GABA(A)R-mediated synaptic inhibition whereas GlyR-mediated tonic action plays a totally different role in regulating hippocampal circuit activity...
  31. pmc GABA, not glycine, mediates inhibition of latent respiratory motor pathways after spinal cord injury
    M Beth Zimmer
    Department of Anatomy and Cell Biology, Wayne State University, 540 East Canfield, Detroit, MI 48201, USA
    Exp Neurol 203:493-501. 2007
    ..These results indicate that phrenic motor neurons are inhibited via a GABA-A mediated receptor mechanism located within the spinal cord to inhibit the expression of crossed phrenic pathways...
  32. ncbi Taurine activates glycine and gamma-aminobutyric acid A receptors in rat substantia gelatinosa neurons
    Jun Wu
    Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Neuroreport 19:333-7. 2008
    ..Altogether these results show that taurine might represent another important neurotransmitter or modulator in SG neurons, which may be involved in antinociception...
  33. ncbi Differential inhibitory control of semicircular canal nerve afferent-evoked inputs in second-order vestibular neurons by glycinergic and GABAergic circuits
    Stefan Biesdorf
    Laboratoire de Neurobiologie des Reseaux Sensorimoteurs, Centre National de la Recherche Scientifique, Unité Miste de Recherche 7060, Université Descartes, Paris, France
    J Neurophysiol 99:1758-69. 2008
    ....
  34. ncbi Local inhibition shapes duration tuning in the inferior colliculus of guinea pigs
    Shankai Yin
    The Affiliated Sixth People s Hospital, Otolaryngology Institute of Shanghai Jiao Tong University, 600 Yishan Road, 7th Building Rm220, Shanghai 200233, China
    Hear Res 237:32-48. 2008
    ..In conclusion, the inhibitory effect on the early responses appears to be the main contributor for the duration selectivity of the IC in guinea pigs; potential mechanisms for this duration selectivity are also discussed...
  35. ncbi Corelease of GABA/glycine in lamina-X of the spinal cord of neonatal rats
    Riad Seddik
    Department of Physiology, University of Basel, Pharmazentrum, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Neuroreport 18:1025-9. 2007
    ..In addition, acetylcholine can induce the release of gamma-amino-n-butyric acid/glycine by acting presynaptically at nicotinic receptors located on the gamma-amino-n-butyric acid ergic/glycinergic terminals...
  36. pmc GABAA and glycine receptor-mediated transmission in rat lamina II neurones: relevance to the analgesic actions of neuroactive steroids
    Elizabeth A Mitchell
    Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    J Physiol 583:1021-40. 2007
    ..These findings are relevant to modulation of inhibitory circuits within spinally mediated pain pathways and suggest that extrasynaptic GABA(A)Rs may represent a relevant molecular target for the analgesic actions of neurosteroids...
  37. ncbi Synaptic responses of neurons controlling the parotid and von Ebner salivary glands in rats to stimulation of the solitary nucleus and tract
    Takeshi Suwabe
    Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    J Neurophysiol 99:1267-73. 2008
    ..Difference in the synaptic characteristics of ISN neurons controlling the parotid and von Ebner glands may relate to the different function of these two glands...
  38. ncbi Glycinergic input of small-field amacrine cells in the retinas of wildtype and glycine receptor deficient mice
    J Weiss
    Department of Neuroanatomy, Max Planck Institute for Brain Research, Deutschordenstr 46, D 60528 Frankfurt Main, Germany
    Mol Cell Neurosci 37:40-55. 2008
    ..Glycinergic sIPSCs of NF cells had slow kinetics (tau=27+/-6.8 ms) that were significantly prolonged in Glra2-/- mice (tau=69+/-16 ms). These data show that morphologically distinct amacrine cells express different sets of GlyRs...
  39. ncbi Inhibitory feedback shapes bipolar cell responses in the rabbit retina
    Alyosha Molnar
    Department of Electrical Engineering and Computer Science, University of California Berkeley, Berkeley, CA 94720, USA
    J Neurophysiol 98:3423-35. 2007
    ..Thus morphologically diverse bipolar cells receive only four main types of inhibitory input, and the majority of "inhibitory" inputs actually serve to enhance excitation...
  40. ncbi The glycine transporter GlyT2 controls the dynamics of synaptic vesicle refilling in inhibitory spinal cord neurons
    France Rousseau
    Laboratoire de Neurobiologie, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 28:9755-68. 2008
    ..Thus, our results demonstrate the central role played by GlyT2 in determining inhibitory phenotype and therefore in the physiology and pathology of inhibitory circuits...
  41. ncbi Slow inhibitory potentials in the teleost Mauthner cell
    K Hatta
    , INSERM U261, Institut Pasteur, 25, rue du Dr Roux, 75724 Cedex 15, Paris, France
    Neuroscience 103:561-79. 2001
    ..In physiological conditions, this regulatory influence is expressed as a continuous shunt of this neuron's input resistance and responsiveness to sensory inputs...
  42. ncbi Synaptic physiology in the cochlear nucleus angularis of the chick
    Katrina M MacLeod
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    J Neurophysiol 93:2520-9. 2005
    ..5 ms, which was heavily influenced by the membrane time constant. Thus NA neurons spatially and temporally integrate auditory information arriving from multiple auditory nerve afferents...
  43. ncbi Inhibitory synapses in the developing auditory system are glutamatergic
    Deda C Gillespie
    Department of Neurobiology, University of Pittsburgh School of Medicine, W1412 Biomedical Science Tower, 3500 Terrace St, Pittsburgh, Pennsylvania 15261, USA
    Nat Neurosci 8:332-8. 2005
    ..Synapse-specific activation of NMDARs by glutamate release at GABAergic and glycinergic synapses could be important in activity-dependent refinement of inhibitory circuits...
  44. ncbi Glycinergic inhibition in thalamus revealed by synaptic receptor blockade
    Ahmad A Ghavanini
    Department of Pharmacology and Therapeutics, The University of British Columbia, Vancouver, BC, Canada
    Neuropharmacology 49:338-49. 2005
    ..Strychnine lacked effects on monosynaptic, GABAergic IPSPs from zona incerta. The specific actions of strychnine implicated a glycine receptor contribution to fast inhibition in somatosensory thalamus...
  45. ncbi Characterization of the glycinergic input to bipolar cells of the mouse retina
    Elena Ivanova
    Department Neuroanatomy, Max Planck Institute for Brain Research, Frankfurt Main, Germany
    Eur J Neurosci 23:350-64. 2006
    ..Thus, different bipolar cell types receive kinetically fast glycinergic inputs, preferentially mediated by GlyRs composed of alpha1 and beta subunits...
  46. ncbi GABAergic and glycinergic inhibitory mechanisms in the lamprey respiratory control
    Fulvia Bongianni
    Dipartimento di Scienze Fisiologiche, Universita degli Studi di Firenze, Viale G B Morgagni 63, I 50134 Firenze, Italy
    Brain Res 1090:134-45. 2006
    ....
  47. ncbi Transition from GABAergic to glycinergic synaptic transmission in newly formed spinal networks
    B X Gao
    Department of Physiology and Center for Neuroscience, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Neurophysiol 86:492-502. 2001
    ..The developmental switch from predominantly long-duration GABAergic inhibitory synaptic currents to short-duration glycinergic currents might serve as a mechanism regulating neuronal excitation in the developing spinal networks...
  48. ncbi Absence of GABA type A signaling in adult medial habenular neurons
    D G Wang
    Department of Neurobiology and Biophysics, School of Life Sciences, University of Science and Technology of China, Huang Shan Road, Hefei 230027, Anhui, China
    Neuroscience 141:133-41. 2006
    ..Further exploration for factors determining medial habenular nucleus neural inhibition will lead to a more complete understanding of control of synaptic balance in the CNS...
  49. ncbi Differential contribution of GABAergic and glycinergic components to inhibitory synaptic transmission in lamina II and laminae III-IV of the young rat spinal cord
    Perrine Inquimbert
    Universite Louis Pasteur, Institut des Neurosciences Cellulaires et Intégratives INCI, Centre National de la Recherche Scientifique CNRS, UMR7168, F 67084 Strasbourg, France
    Eur J Neurosci 26:2940-9. 2007
    ..Our results indicate that, compared with lamina II, inhibitory synaptic transmission in laminae III-IV is characterized by a dominant role of glycinergic inhibition and the absence of a functional GABA/glycine co-transmission...
  50. ncbi Local circuit connections between hamster laminae III and IV dorsal horn neurons
    Stephen P Schneider
    Department of Physiology and Neuroscience Program, Michigan State University, East Lansing, MI 48824 3320, USA
    J Neurophysiol 99:1306-18. 2008
    ....
  51. ncbi When symptoms persist: clozapine augmentation strategies
    P Buckley
    Department of Psychiatry, Medical College of Georgia, Augusta 30912, USA
    Schizophr Bull 27:615-28. 2001
    ..Current systematic efforts to enhance the treatment of these patients with adjunctive therapies are worthy of being studied in carefully conducted clinical trials...
  52. ncbi Neuroprotective effect of L-serine against temporary cerebral ischemia in rats
    Guo hua Wang
    Department of Neuropharmacology, Institute of Nautical Medicine, Nantong University, Nantong, China
    J Neurosci Res 88:2035-45. 2010
    ..It is suggested that L-serine could exert a neuroprotective effect on the ischemic-reperfused brain and on the hypoxia- or glutamate-exposed hippocampal neurons, which may be mediated by activating glycine receptors...
  53. pmc Ethanol reduces neuronal excitability of lateral orbitofrontal cortex neurons via a glycine receptor dependent mechanism
    Kimberly A Badanich
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 38:1176-88. 2013
    ....
  54. ncbi A critical role of the strychnine-sensitive glycinergic system in spontaneous retinal waves of the developing rabbit
    Z J Zhou
    Department of Physiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurosci 21:5158-68. 2001
    ..Overall, the results revealed an important reliance of spontaneous retinal waves on dynamic and coordinated interactions among multiple, nonredundant neurotransmitter systems...
  55. ncbi Asymmetric cross-inhibition between GABAA and glycine receptors in rat spinal dorsal horn neurons
    Yong Li
    Department of Neurobiology and Biophysics, University of Science and Technology of China, Hefei 230027, China
    J Biol Chem 278:38637-45. 2003
    ....
  56. pmc Vestibular-mediated synaptic inputs and pathways to sympathetic preganglionic neurons in the neonatal mouse
    Nedim Kasumacic
    Laboratory of Neural Development and Optical Recording NDEVOR, Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, N 0317 Oslo, Norway
    J Physiol 590:5809-26. 2012
    ..Thus, already at birth, synaptic connections in the vestibulosympathetic reflex are functional and require the involvement of the ventrolateral medulla as in adult mammals...
  57. ncbi Comparison of glycine- and GABA-evoked currents in two types of neurons isolated from the rat striatum
    O A Sergeeva
    Department of Physiology II, Heinrich Heine Universitat, Dusseldorf, Germany
    Neurosci Lett 243:9-12. 1998
    ..GABA- and glycine- responses were additive and blocked selectively by bicuculline (1 microM) and strychnine (50 nM), respectively. These results predict the presence of alpha- and beta-subunits of the glycine receptor in the striatum...
  58. ncbi Chronic pain states: pharmacological strategies to restore diminished inhibitory spinal pain control
    Hanns Ulrich Zeilhofer
    Institute of Pharmacology and Toxicology, University of Zurich, CH 8057 Zurich, Switzerland
    Annu Rev Pharmacol Toxicol 52:111-33. 2012
    ....
  59. ncbi Long-term potentiation of intrinsic excitability in trigeminal motoneurons
    Reiko Okamoto
    1st Department of Oral Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Brain Res 1312:32-40. 2010
    ..These findings indicate that TMNs exhibit LTP of intrinsic excitability...
  60. pmc Spatial segregation of adaptation and predictive sensitization in retinal ganglion cells
    David B Kastner
    Neuroscience Program, Stanford University School of Medicine, 299 Campus Drive West, Stanford, CA, USA
    Neuron 79:541-54. 2013
    ..Within this framework, we show that sensitization predicts the location of a nearby object, revealing prediction as a functional role for adapting inhibition in the nervous system...
  61. ncbi Implications for glycine receptors and astrocytes in ethanol-induced elevation of dopamine levels in the nucleus accumbens
    Louise Adermark
    Department of Psychiatry and Neurochemistry, Institute for Neuroscience and Physiology, University of Gothenburg, Sweden
    Addict Biol 16:43-54. 2011
    ..In conclusion, our data suggest that extracellular concentrations of dopamine and taurine are interconnected and that swelling of astrocytes contributes to the acute rewarding sensation of EtOH...
  62. pmc Role of synaptic inhibition in turtle respiratory rhythm generation
    Stephen M Johnson
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA
    J Physiol 544:253-65. 2002
    ..Thus, these data indicate that the adult turtle respiratory rhythm generator has the potential to operate in a pacemaker-driven manner...
  63. ncbi Approaches to the synthesis of (+/-)-strychnine via the cobalt-mediated [2 + 2 + 2] cycloaddition: rapid assembly of a classic framework
    M J Eichberg
    Center for New Directions in Organic Synthesis, Department of Chemistry, University of California at Berkeley, 94720-1460, USA
    J Am Chem Soc 123:9324-37. 2001
    ..Numerous attempts toward the formation of the piperidine ring of 1 from vinyl iodide 56 were made and its successful formation via palladium-, nickel-, and radical-mediated processes is described...
  64. pmc Differential distribution of glycine receptor subtypes at the rat calyx of held synapse
    Bohdana Hruskova
    Department of Auditory Neuroscience, Institute of Experimental Medicine ASCR, 14220 Prague, Czech Republic
    J Neurosci 32:17012-24. 2012
    ..These results suggest that specific targeting of GlyR β-subunit produces segregation of GlyR subtypes involved in two different mechanisms of modulation of synaptic strength...
  65. ncbi Minimizing synaptic depression by control of release probability
    S Brenowitz
    Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 21:1857-67. 2001
    ..Thus, presynaptic modulation by GABA(B) receptors regulates the extent of AMPA receptor desensitization and controls synaptic strength, thereby modulating the flow of information at an auditory synapse...
  66. pmc Protection of ATP-depleted cells by impermeant strychnine derivatives: implications for glycine cytoprotection
    Z Dong
    Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Pathol 158:1021-8. 2001
    ..Cytoprotective effects of the cell-impermeant strychnine derivative provide compelling evidence suggesting that molecular targets on the outer surface of plasma membranes may mediate cytoprotection by strychnine and glycine...
  67. ncbi Respiratory rhythm generation in mammals: synaptic and membrane properties
    J M Ramirez
    Department of Organismal Biology and Anatomy, University of Chicago, IL 60637, USA
    Respir Physiol 110:71-85. 1997
    ....
  68. ncbi GABAergic and glycinergic neural inhibition in excitatory frequency tuning of bat inferior collicular neurons
    Y Lu
    Division of Biological Sciences, University of Missouri-Columbia, MO 65211, USA
    Exp Brain Res 141:331-9. 2001
    ..Application of both drugs was most effective in abolishing the inhibitory FTCs of IC neurons. The implications of these findings for bat echolocation are discussed...
  69. pmc Short-term modulation at synapses between neurons in laminae II-V of the rodent spinal dorsal horn
    W Zhang
    Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    J Neurophysiol 105:2920-30. 2011
    ..These results are evidence of diversity in synaptic transmission between dorsal horn neurons, the nature of which may depend on the types of linkage, laminar location, and intrinsic firing properties of postsynaptic cells...
  70. ncbi Stabilization of bursting in respiratory pacemaker neurons
    Andrew K Tryba
    The University of Chicago, Department of Organismal Biology and Anatomy, Chicago, Illinois 60637, USA
    J Neurosci 23:3538-46. 2003
    ..001; n = 14). We conclude that respiratory pacemaker neurons possess membrane properties that stabilize their bursting against changes in [K+]o and imposed changes in V(m)...
  71. ncbi Differential effects of divalent cations on spontaneous and evoked glycine release from spinal interneurons
    Megumi Maeda
    Department of Physiology, Kurume University School of Medicine, Kurume, Japan
    J Neurophysiol 101:1103-13. 2009
    ..The different mechanisms might be explained by the different sensitivity of synaptotagmin isoforms to Ca2+, Sr2+, and Ba2+...
  72. doi Propofol for the management of glycine-mediated excitatory symptoms of TURP syndrome
    P Bhakta
    Eur J Anaesthesiol 25:430-2. 2008
  73. ncbi [Effectiveness of different iron supplementation strategies on hemoglobin and ferritin levels among schoolchildren in Teresina, Piauí State, Brazil]
    Marize Melo Dos Santos
    Departamento de Nutricao, Universidade Federal do Piaui, Teresina, Brasil
    Cad Saude Publica 23:1547-52. 2007
    ..05) was observed. The results confirm the effectiveness of the iron supplementation interventions and corroborate the use of iron salts or ferrous bisglycinate chelate on a weekly basis to overcome iron deficiency and anemia...
  74. ncbi Hemoglobin induces cytotoxic damage of glycine-preserved renal tubules
    M R Moussavian
    Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, Homburg Saar, Germany
    Transpl Int 20:884-94. 2007
    ..DFO reduced significantly the reoxygenation damage of free Hb and iron ions. Our data clearly demonstrate a pronounced cytotoxic effect of free Hb in ITS, which critically depended on the reduction state of the iron ions...
  75. ncbi Glycine receptor knock-in mice and hyperekplexia-like phenotypes: comparisons with the null mutant
    Geoffrey S Findlay
    Waggoner Center for Alcohol and Addiction Research, Section of Neurobiology, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 23:8051-9. 2003
    ....
  76. ncbi Taurine and the control of basal hormone release from rat neurohypophysis
    Zhilin Song
    Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA
    Exp Neurol 183:330-7. 2003
    ..Taurine-induced partial depolarization resulting in Na(+) channel inactivation is probably responsible for its previously observed inhibition of stimulated hormone release from neural lobe...
  77. ncbi Hamster sperm glycine receptor: evidence for its presence and involvement in the acrosome reaction
    M N Llanos
    Unidad de Biología de la Reproducción, INTA, Universidad de Chile, Santiago, Chile
    Mol Reprod Dev 58:205-15. 2001
    ..Taken together these results strongly suggest the presence of a GlyR in the hamster spermatozoa, with a role in the AR when activated...
  78. pmc Loss of GABAB receptors in cochlear neurons: threshold elevation suggests modulation of outer hair cell function by type II afferent fibers
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114 3096, USA
    J Assoc Res Otolaryngol 10:50-63. 2009
    ..Our results suggest that GABAergic signaling in type II afferent neurons may be required for normal outer hair cell amplifier function at low sound levels and may also modulate outer hair cell responses to high-level sound...
  79. pmc Opposite changes in synaptic activity of organotypic rat spinal cord cultures after chronic block of AMPA/kainate or glycine and GABAA receptors
    M Galante
    Biophysics Sector and Istituto Nazionale di Fisica della Materia Unit, International School for Advanced Studies SISSA, Via Beirut 4, 34014 Trieste, Italy
    J Physiol 523:639-51. 2000
    ....
  80. pmc The role of the paraventricular nucleus of the hypothalamus in the regulation of cardiac and renal sympathetic nerve activity in conscious normal and heart failure sheep
    Rohit Ramchandra
    Florey Neuroscience Institutes, University of Melbourne, Parkville, Victoria 3010, Australia
    J Physiol 591:93-107. 2013
    ..These findings indicate the PVN has a greater influence on RSNA than CSNA in the resting state in normal and HF sheep, and during volume expansion in normal sheep...
  81. pmc Gycine and GABA interact to regulate the nitric oxide/cGMP signaling pathway in the turtle retina
    Dou Yu
    Boston University, Program in Neuroscience, Massachusetts 02215, USA
    Vis Neurosci 22:825-38. 2005
    ..Such interacting inhibitory pathways could shape the course of signal transduction of the NO/cGMP pathway under different physiological situations...
  82. pmc A role for melanopsin in alpha retinal ganglion cells and contrast detection
    Tiffany M Schmidt
    Johns Hopkins University, Department of Biology, Baltimore, MD 21218, USA Electronic address
    Neuron 82:781-8. 2014
    ..These findings indicate a surprising role for melanopsin and ipRGCs in vision...
  83. ncbi Medullary lateral tegmental field neurons influence the timing and pattern of phrenic nerve activity in cats
    Hakan S Orer
    Dept of Pharmacology and Toxicology, Michigan State Univ, East Lansing, MI 48824, USA
    J Appl Physiol 101:521-30. 2006
    ..We propose that a proper balance of excitatory and inhibitory inputs to several functionally distinct pools of LTF neurons is essential for maintaining the normal pattern of PNA in anesthetized cats...
  84. pmc Reciprocal regulation between taurine and glutamate response via Ca2+-dependent pathways in retinal third-order neurons
    Simon Bulley
    College of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431, USA
    J Biomed Sci 17:S5. 2010
    ..The reciprocal inhibition between taurine and glutamate in the postsynaptic neurons contributes to computation of visual signals in the retinal neurons...
  85. ncbi Building a better antipsychotic: receptor targets for the treatment of multiple symptom dimensions of schizophrenia
    Dennis H Kim
    Arbor Scientia, Carlsbad, California 92008, USA
    Neurotherapeutics 6:78-85. 2009
    ..In this article we present a discussion of some of the receptor targets that are currently thought to mediate symptoms of schizophrenia, as well as their possible implications for the design of future multifunctional antipsychotics...
  86. pmc Actions of 3-[2-phosphonomethyl[1,1-biphenyl]-3-yl]alanine (PMBA) on cloned glycine receptors
    A M Hosie
    Department of Pharmacology, The Tokyo Metropolitan Institute of Medical Science, Japan
    Br J Pharmacol 126:1230-6. 1999
    ..PMBA may provide a lead structure for novel antagonists with which to investigate structural differences in glycine receptor at alpha1 and alpha2 subunits...
  87. ncbi Active roles of electrically coupled bipolar cell network in the adult retina
    Itaru Arai
    Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Neurosci 30:9260-70. 2010
    ..These results suggest that the spread of Ca(2+) spikes through gap junctions between bipolar cells may play a key role in lateral interactions in the adult retina...
  88. ncbi Nitric oxide selectively tunes inhibitory synapses to modulate vertebrate locomotion
    David L McLean
    School of Biology, Division of Biomedical Sciences, University of St Andrews, St Andrews, Fife KY16 9TS, United Kingdom
    J Neurosci 22:4175-84. 2002
    ..The presynaptic and postsynaptic effects of NO act in concert to tune inhibitory synapses...
  89. ncbi NMDA and strychnine diversely modulate spinal dorsal horn noxious responsiveness in normal rats: potential significance to sensory disorders in neuropathic pain
    Maria Luisa Sotgiu
    Istituto di Neuroscienze e Bioimmagini, CNR, Segrate, Milan, Italy
    Somatosens Mot Res 19:18-23. 2002
    ..This suggests, by inference, a crucial contribution of the NMDA-induced increased excitability to the expression of neuronal sensitization related to this painful sensory disorder...
  90. pmc Nitric oxide facilitates GABAergic neurotransmission in the cat oculomotor system: a physiological mechanism in eye movement control
    Bernardo Moreno-López
    Area de Fisiologia, Facultad de Medicina, Universidad de Cadiz, Spain
    J Physiol 540:295-306. 2002
    ..This self-control mechanism could play an important role in the maintenance of the vestibular balance necessary to generate a stable and adequate eye position signal...
  91. ncbi Common sensory inputs and differential excitability of segmentally homologous reticulospinal neurons in the hindbrain
    Hisako Nakayama
    Division of Biophysical Engineering, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, Japan
    J Neurosci 24:3199-209. 2004
    ..2, a DTX-I-sensitive potassium channel subunit. Thus, the M-cell and its segmental homologs may sense common auditory information but send different outputs to the spinal circuits to control adaptive escape behavior...
  92. ncbi Trigeminal reflex regulation of the glottis depends on central glycinergic inhibition in the rat
    Mathias Dutschmann
    Department of Animal Physiology, University of Tubingen, Auf der Morgenstelle 28, 72076 Tubingen, Germany
    Am J Physiol Regul Integr Comp Physiol 282:R999-R1005. 2002
    ..Thus the integrity of glycinergic inhibition within the pontomedullary respiratory network is critical for the coordination of cranial and spinal motor outflows during eupnea but also for protective reflex regulation of the upper airway...
  93. pmc Short-term synaptic plasticity regulates the level of olivocochlear inhibition to auditory hair cells
    Jimena Ballestero
    Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    J Neurosci 31:14763-74. 2011
    ..Thus, we have demonstrated that short-term plasticity is responsible for shaping MOC inhibition and, therefore, encodes the transfer function from efferent firing frequency to the gain of the cochlear amplifier...
  94. ncbi A paradigm shift in mechanical biofilm management? Subgingival air polishing: a new way to improve mechanical biofilm management in the dental practice
    Anton Sculean
    Department of Periodontology, University of Bern, Bern, Switzerland
    Quintessence Int 44:475-7. 2013
    ..This paper summarizes the main conclusions of the consensus conference and points to the clinical relevance of the findings for the dental practitioner...
  95. pmc Glycinergic inhibition is essential for co-ordinating cranial and spinal respiratory motor outputs in the neonatal rat
    M Dutschmann
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 543:643-53. 2002
    ....
  96. ncbi Antagonists of ionotropic gamma-aminobutyric acid receptors impair the NiCl2-mediated stimulation of the electroretinogram b-wave amplitude from the isolated superfused vertebrate retina
    Siarhei A Siapich
    Institute of Neurophysiology, University of Cologne, Germany
    Acta Ophthalmol 87:854-65. 2009
    ..51-fold increase) and (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA; 1.46-fold increase) on the b-wave amplitude...
  97. ncbi Glycine binding site of the synaptic NMDA receptor in subpostremal NTS neurons
    Vander Baptista
    Department of Physiology, School of Medicine of Ribeirão Preto University of São Paolo, Av Bandeirantes 3900, 14049 900 Ribeirao Preto SP, Brazil
    J Neurophysiol 94:147-52. 2005
    ..Our results indicate that the glycine site of the NMDA receptor in neurons of the subpostremal NTS is not saturated and that glycine may act as a modulator of the NMDA transmission in this nucleus...
  98. ncbi Iontophoresis in vivo demonstrates a key role for GABA(A) and glycinergic inhibition in shaping frequency response areas in the inferior colliculus of guinea pig
    F E LeBeau
    Department of Physiological Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Neurosci 21:7303-12. 2001
    ....
  99. ncbi Phospholipase A2 activation enhances inhibitory synaptic transmission in rat substantia gelatinosa neurons
    Tao Liu
    Department of Physiology, Saga Medical School, 5 1 1 Nabeshima, Saga, Japan
    J Neurophysiol 99:1274-84. 2008
    ..It is suggested that PLA(2) activation in the SG could enhance not only excitatory but also inhibitory transmission, resulting in the modulation of nociception...
  100. ncbi Acute high-dose glycine attenuates mismatch negativity (MMN) in healthy human controls
    Sumie Leung
    Brain Sciences Institute, Swinburne University of Technology, Melbourne, Australia
    Psychopharmacology (Berl) 196:451-60. 2008
    ..However, no study has investigated the possible effects of high-dose glycine on MMN. Further, the physiological consequences of administering high-dose glycine in subjects with normal NMDA receptor function are unknown...
  101. ncbi Homeostatic plasticity induced by chronic block of AMPA/kainate receptors modulates the generation of rhythmic bursting in rat spinal cord organotypic cultures
    M Galante
    Biophysics Sector and Istituto Nazionale di Fisica della Materia Unit, International School for Advanced Studies (SISSA, Via Beirut 2-4, 34014 Trieste, Italy
    Eur J Neurosci 14:903-17. 2001
    ..Conversely, in control slices GABAergic transmission depressed spontaneous activity but it facilitated bursting frequency. Thus, even after homeostatic rearrangement, developing mammalian spinal networks still generate rhythmic activity...

Research Grants33

  1. ETHANOL EFFECTS ON GLYCINE RECEPTOR/CHANNEL FUNCTION
    Jiang Hong Ye; Fiscal Year: 2003
    ....
  2. Neurobiol mechanism/acupuncture therapy/alcoholism
    Jiang Hong Ye; Fiscal Year: 2004
    ..This new knowledge will have a major impact on our understanding of how acupuncture works. The application of this knowledge is expected to improve the effectiveness of acupuncture treatment in alcohol addiction. ..
  3. Ethanol and mesolimbic GABAergic neurons
    Jiang Hong Ye; Fiscal Year: 2007
    ..Such results will provide valuable information on novel mechanisms underlying the addictive properties of alcohol and a firm scientific foundation for future neurobiological studies. [unreadable] [unreadable] [unreadable]..
  4. Ca permeable non-NMDAr: New spinal sensitization pathway
    Linda Sorkin; Fiscal Year: 2005
    ..We propose to investigate the effects of Ca-permeable non-NMDAr activation on ERK and CREB phosphorylation (using Western blots and immunohistochemistry), expression of c-fos and development of hyperalgesia. ..
  5. Cytokine and MAP Kinase Involvement in Neuropathic Pain
    Linda Sorkin; Fiscal Year: 2008
    ..This approach has the potential for avoiding some of the problems that occur with complete inhibition of p38 function. ..
  6. Coupling & Reconfiguration of Rhythmic Motor Networks
    Stephen Johnson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  7. PLASTICITY OF SPINAL RESPIRATORY SYNAPTIC TRANSMISSION
    Stephen Johnson; Fiscal Year: 2001
    ....
  8. Annual Meeting of the American Pain Society
    Linda Sorkin; Fiscal Year: 2005
    ..Abstracts will be judged on scientific merit and published in The Journal of Pain. We believe that these awards will encourage meeting attendance by trainees. ..
  9. Inflammatory and Infectious Burden and Risk of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..The cross-sectional associations between inflammatory and infectious markers and quantitative MRI abnormalities will also be assessed. ..
  10. Synaptic Pathways in the Mammalian Retina
    EDMUND TREXLER; Fiscal Year: 2008
    ..abstract_text> ..
  11. A CONFOCAL MICROSCOPE FOR NEUROBIOLGY
    Stephen Schneider; Fiscal Year: 2001
    ..Acquisition of the LSM 5 will significantly enhance the research programs of the major users and aid other investigators in the broader MSU research community. ..
  12. Levels of Inflammatory Markers in Treatment of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..abstract_text> ..
  13. Genes Underlying the Response to Inhaled Anesthetics
    James Sonner; Fiscal Year: 2008
    ....
  14. Ethanol & Anxiety: Cellular Mechanisms
    BRIAN MCCOOL; Fiscal Year: 2008
    ..These studies could therefore provide insight into the cellular mechanisms governing anxietyassociated relapse in human alcoholics. ..
  15. Phase 2B Study of TNK in Acute Stroke
    E Haley; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  16. Enhancing the Prospective Prediction of Psychosis
    Scott Woods; Fiscal Year: 2007
    ..Each site has provefi its ability to recruit prodromal patients in a previous collaboration. ..
  17. Potentiation of Glycine Receptors by Ethanol
    LUIS GERARDO AGUAYO; Fiscal Year: 2010
    ....
  18. DOPAMINE AND RETINAL ADAPTATION
    Paul Witkovsky; Fiscal Year: 2001
    ....
  19. RESPIRATORY SYSTEM INTEGRATION BY THE BRAINSTEM
    ALBERT BERGER; Fiscal Year: 2002
    ..We hypothesize that ethanol increases the affinity of glycine-Rs for glycine and thereby potentiates inhibitory synaptic events. This may be an important mechanism whereby alcohol consumption exacerbates obstructive sleep apnea. ..
  20. TREATMENT OF PANIC DISORDER--LONG TERM STRATEGIES
    Scott Woods; Fiscal Year: 2003
    ..Thus, we are proposing to add these aims. ..
  21. TARDIVE DYSKINESIA INCIDENCE AND ATYPICAL ANTIPSYCHOTIC
    Scott Woods; Fiscal Year: 2004
    ..The existence of a previous sample at the same site provides a useful additional comparison group. Methods including sample ascertainment and TD assessment are closely modeled after the original work. ..
  22. Analysis of MEPSC shape at photoreceptor ribbon synapses
    BRUCE MAPLE; Fiscal Year: 2005
    ..abstract_text> ..
  23. DEVELOPMENT OF SENSORY/MOTOR SYNAPSES IN THE SPINAL CORD
    Eric Frank; Fiscal Year: 2005
    ....
  24. Retinal Inputs to the Mammalian Circadian Pacemaker
    KWOON WONG; Fiscal Year: 2006
    ..These experiments may enable a better understanding of how the mammalian circadian pacemaker is regulated, which in turn may lead to better therapies and workplace policies combating/preventing jet lag problems. ..
  25. GABA-A Receptors, Ethanol, and Stress in Monkey Amygdala
    BRIAN MCCOOL; Fiscal Year: 2006
    ..Ultimately, our proposed studies will help lead to a better understanding of the ethanol-anxiety/stress interaction in primates. ..
  26. Robotic Preparation of cDNA Single Cells
    William Cleveland; Fiscal Year: 2006
    ..In summary, we believe that an instrument which couples multidimensional microscopy with DNA array technology will be a spectacular tool that will be useful to many laboratories. ..
  27. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
    ..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
  28. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 2008
    ..Such information might provide insights into dysfunctions of the control of ventilation in humans, such as in "sleep apnea" or the "sudden infant death syndrome." [unreadable] [unreadable] [unreadable]..
  29. Mechanisms Underlying Rhythm Generation in Identified Spinal Interneurons in Mice
    Lea Ziskind Conhaim; Fiscal Year: 2010
    ....
  30. Repair of Brachial Sensory Root Injuries in the Spinal Cord
    Eric Frank; Fiscal Year: 2010
    ..The goal of these experiments is to determine if artemin is sufficiently effective to warrant study for the repair of brachial root injuries in humans. ..
  31. MECHANISMS OF LOCAL SYNAPTIC TRANSMISSION IN DORSAL HORN
    Stephen Schneider; Fiscal Year: 2007
    ..The studies will provide essential information about dynamic modulation of synaptic function underlying spinal integration of innocuous and noxious sensory information. ..
  32. Background sodium currents in respiratory pacemakers
    ANDREW TRYBA; Fiscal Year: 2009
    ..This research will lead to better understanding of the ionic mechanisms behind the generation of regular versus irregular rhythmic respiratory activity. ..