gaba antagonists


Summary: Drugs that bind to but do not activate GAMMA-AMINOBUTYRIC ACID receptors, thereby blocking the actions of endogenous GAMMA-AMINOBUTYRIC ACID or GAMMA-AMINOBUTYRIC ACID agonists.

Top Publications

  1. ncbi GABA uptake regulates cortical excitability via cell type-specific tonic inhibition
    Alexey Semyanov
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Nat Neurosci 6:484-90. 2003
  2. ncbi Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells
    Zoltan Nusser
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
    J Neurophysiol 87:2624-8. 2002
  3. ncbi Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons
    D Bai
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Mol Pharmacol 59:814-24. 2001
  4. ncbi Activation of GABAA receptors: views from outside the synaptic cleft
    Joseph Glykys
    Interdepartmental PhD Program for Neuroscience, The David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Neuron 56:763-70. 2007
  5. ncbi Alcohol enhances GABAergic transmission to cerebellar granule cells via an increase in Golgi cell excitability
    Mario Carta
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    J Neurosci 24:3746-51. 2004
  6. ncbi Hippocampal network hyperactivity after selective reduction of tonic inhibition in GABA A receptor alpha5 subunit-deficient mice
    Joseph Glykys
    Interdepartmental PhD Program for Neuroscience and Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    J Neurophysiol 95:2796-807. 2006
  7. pmc Multiple modes of GABAergic inhibition of rat cerebellar granule cells
    David J Rossi
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 548:97-110. 2003
  8. ncbi Identified sources and targets of slow inhibition in the neocortex
    Gabor Tamas
    Department of Comparative Physiology, University of Szeged, Közép fasor 52, Szeged H 6726, Hungary
    Science 299:1902-5. 2003
  9. ncbi Distinct roles of GABA(A) and GABA(B) receptors in balancing and terminating persistent cortical activity
    Edward O Mann
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX13PT, United Kingdom
    J Neurosci 29:7513-8. 2009
  10. ncbi Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit
    K A Wafford
    Merck Sharp and Dohme Research Laboratories, Harlow, Essex, UK
    Mol Pharmacol 50:670-8. 1996

Research Grants

Detail Information

Publications275 found, 100 shown here

  1. ncbi GABA uptake regulates cortical excitability via cell type-specific tonic inhibition
    Alexey Semyanov
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Nat Neurosci 6:484-90. 2003
    ..Reducing the tonic conductance in interneurons enhanced their excitability and the inhibitory drive to pyramidal cells. These results point to a role for cell type-dependent tonic inhibition in regulating cortical excitability...
  2. ncbi Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells
    Zoltan Nusser
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
    J Neurophysiol 87:2624-8. 2002
    ..Furthermore, we have identified distinct pharmacological tools to selectively modify tonic and phasic inhibitions, allowing future studies to investigate their specific roles in neuronal function...
  3. ncbi Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons
    D Bai
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Mol Pharmacol 59:814-24. 2001
    ..In summary, the receptors underlying the tonic current are functionally and pharmacologically distinct from quantally activated synaptic receptors and these receptors represent a novel target for neurodepressive drugs...
  4. ncbi Activation of GABAA receptors: views from outside the synaptic cleft
    Joseph Glykys
    Interdepartmental PhD Program for Neuroscience, The David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Neuron 56:763-70. 2007
    ..These same receptors constitute important and specific targets for various endogenous and exogenous neuroactive compounds and possible therapeutic targets...
  5. ncbi Alcohol enhances GABAergic transmission to cerebellar granule cells via an increase in Golgi cell excitability
    Mario Carta
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    J Neurosci 24:3746-51. 2004
    ..This effect is likely to have an impact on the flow of information through the cerebellar cortex and may contribute to the mechanism by which acute ingestion of alcoholic beverages induces motor impairment...
  6. ncbi Hippocampal network hyperactivity after selective reduction of tonic inhibition in GABA A receptor alpha5 subunit-deficient mice
    Joseph Glykys
    Interdepartmental PhD Program for Neuroscience and Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    J Neurophysiol 95:2796-807. 2006
  7. pmc Multiple modes of GABAergic inhibition of rat cerebellar granule cells
    David J Rossi
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 548:97-110. 2003
  8. ncbi Identified sources and targets of slow inhibition in the neocortex
    Gabor Tamas
    Department of Comparative Physiology, University of Szeged, Közép fasor 52, Szeged H 6726, Hungary
    Science 299:1902-5. 2003
    ..Slow inhibition evoked by a distinct interneuron in spatially restricted postsynaptic compartments could locally and selectively modulate cortical excitability...
  9. ncbi Distinct roles of GABA(A) and GABA(B) receptors in balancing and terminating persistent cortical activity
    Edward O Mann
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX13PT, United Kingdom
    J Neurosci 29:7513-8. 2009
    ..These results suggest that while GABA(A) receptor-mediated inhibition is necessary for balancing persistent activity, activation of GABA(B) receptors contributes to terminating Up states...
  10. ncbi Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit
    K A Wafford
    Merck Sharp and Dohme Research Laboratories, Harlow, Essex, UK
    Mol Pharmacol 50:670-8. 1996
    ..These experiments reveal a unique pharmacology for alpha 4-containing receptors with some similarities to both alpha 6- and alpha 1-containing receptors...
  11. ncbi Pentylenetetrazole-induced inhibition of recombinant gamma-aminobutyric acid type A (GABA(A)) receptors: mechanism and site of action
    R Q Huang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Pharmacol Exp Ther 298:986-95. 2001
    ..Taken together, our results indicate that pentylenetetrazole and picrotoxin interact with overlapping but distinct domains of the GABA(A) receptor...
  12. ncbi Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells
    Anna Wendt
    Department of Physiological Sciences, Lund University, Lund, Sweden
    Diabetes 53:1038-45. 2004
    ..This effect was not observed in the presence of SR95531, and we therefore conclude that isradipine stimulates glucagon secretion by inhibition of GABA release...
  13. pmc High-affinity, slowly desensitizing GABAA receptors mediate tonic inhibition in hippocampal dentate granule cells
    Zakaria Mtchedlishvili
    Department of Neurology, University of Virginia Health Sciences Center, Charlottesville, 22908, USA
    Mol Pharmacol 69:564-75. 2006
  14. ncbi Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition
    F Pouille
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
    Science 293:1159-63. 2001
    ..Thus, the subcellular partitioning of feed-forward inhibition enforces precise coincidence detection in the soma, while allowing dendrites to sum incoming activity over broader time windows...
  15. ncbi Directionally selective calcium signals in dendrites of starburst amacrine cells
    Thomas Euler
    Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Nature 418:845-52. 2002
    ..This demonstrates that direction selectivity is computed locally in dendritic branches at a stage before ganglion cells...
  16. ncbi GABA(A) receptor activation in the lateral parabrachial nucleus induces water and hypertonic NaCl intake
    J C Callera
    Department of Basic Science, School of Dentistry, Paulista State University, UNESP, Aracatuba, SP, Brazil
    Neuroscience 134:725-35. 2005
    ..Therefore the activation of GABA(A) receptors in the lateral parabrachial nucleus induces strong NaCl intake, a small ingestion of water and pressor responses, without changes on food intake...
  17. ncbi The role of GABAergic inhibition on direction-dependent sharpening of frequency tuning in bat inferior collicular neurons
    P H Jen
    Division of Biological Sciences, The University of Missouri Columbia, Missouri, MO, USA
    Brain Res 862:127-37. 2000
    ..e. Q(n) values, two-tailed paired t-test, P<0.01). These data indicate that GABAergic inhibition makes an important contribution to the direction-dependent frequency tuning of most IC neurons...
  18. ncbi Functional expression of AMPA receptors on central terminals of rat dorsal root ganglion neurons and presynaptic inhibition of glutamate release
    C Justin Lee
    Department of Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA
    Neuron 35:135-46. 2002
    ..These results challenge the traditional view that GABA and GABA(A) receptors exclusively mediate PAD, and indicate that PAD is also mediated by glutamate acting on presynaptically localized AMPA and kainate receptors...
  19. ncbi Optical imaging of visual cortex epileptic foci and propagation pathways
    Michael M Haglund
    Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, U S A
    Epilepsia 53:87-97. 2012
    ..This experimental study demonstrates that optical imaging can precisely localize an epileptic focus, and provides excellent spatial resolution of the changes that occur in and around the site of the epileptic focus...
  20. ncbi Monosynaptic and polysynaptic feed-forward inputs to mitral cells from olfactory sensory neurons
    Marion Najac
    Institut National de la Santé et de la Recherche Médicale Unité 603, Paris, France
    J Neurosci 31:8722-9. 2011
    ..These results confirm the existence of direct OSN to mitral cells synapses but also emphasize the prominence of intraglomerular feedforward pathways in the mitral cell response...
  21. pmc A single amino acid determines the toxicity of Ginkgo biloba extracts
    Andrew J Thompson
    Department of Biochemistry, Tennis Court Rd, Cambridge CB2 1QW, UK
    FASEB J 26:1884-91. 2012
    ..biloba extracts can be attributed to their effects at insect GABA receptors, and the presence of a Val at the 2' position in vertebrate GABA(A) receptors explains why these compounds are not similarly toxic to humans...
  22. ncbi Abnormal GABAA receptor-mediated currents in dorsal root ganglion neurons isolated from Na-K-2Cl cotransporter null mice
    K W Sung
    Departments of Anesthesiology, Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, Tennesse, USA
    J Neurosci 20:7531-8. 2000
  23. ncbi Glycine receptor subunit composition alters the action of GABA antagonists
    Ping Li
    Department of Physiology and Biophysics, University at Buffalo, Buffalo, New York 14214, USA
    Vis Neurosci 24:513-21. 2007
    ..But the mixed receptor exhibits a non-competitive picrotoxinin inhibition that is not observed in the homomeric GlyRs. This suggests that glycine and GABA subunits can co-assemble to form functional glycine receptors...
  24. ncbi Synchronization of GABAergic inputs to CA3 pyramidal cells precedes seizure-like event onset in juvenile rat hippocampal slices
    Bálint Lasztóczi
    Dept of Neurochemistry, Institute of Biomolecular Chemistry, Chemical Research Center, Hungarian Academy of Sciences, H 1025, Pusztaszeri ut 59 67, Budapest, Hungary
    J Neurophysiol 102:2538-53. 2009
    ..At the SLE onset GABAergic input contributes to synchronization and recruitment of pyramidal cells. We conjecture that this network state is reached by an activity-dependent shift in GABA reversal potential during the preictal phase...
  25. ncbi Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors
    Shelley H Huang
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, Faculty of Medicine, University of Sydney, NSW 2006, Sydney, Australia
    Eur J Pharmacol 464:1-8. 2003
    ..While bilobalide and picrotoxinin were clearly noncompetitive antagonists, the potency of bilobalide decreased at high GABA concentrations suggesting a component of competitive antagonism...
  26. ncbi Gamma-aminobutyric acid circuits shape response properties of auditory cortex neurons
    Jian Wang
    Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Brain Res 944:219-31. 2002
    ..The inhibitory circuits that generate nonmonotonic rate-level functions are separate from those that influence other response properties of AI neurons...
  27. pmc Two GABAergic intraglomerular circuits differentially regulate tonic and phasic presynaptic inhibition of olfactory nerve terminals
    Z Shao
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, 21201 MD, USA
    J Neurophysiol 101:1988-2001. 2009
    ..Thus olfactory bulb glomeruli contain at least two functionally distinct GABAergic circuits that may play different roles in olfactory coding...
  28. pmc The synaptic mechanism of direction selectivity in distal processes of starburst amacrine cells
    Seunghoon Lee
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Neuron 51:787-99. 2006
  29. ncbi Subtype-specific GABA transporter antagonists synergistically modulate phasic and tonic GABAA conductances in rat neocortex
    Sotirios Keros
    Department of Neurobiology and Civitan International Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurophysiol 94:2073-85. 2005
    ..Thus neocortical GAT-1 and GAT-2/3 have distinct but overlapping roles in modulating GABA conductances...
  30. pmc GABA-mediated Ca2+ signalling in developing rat cerebellar Purkinje neurones
    J Eilers
    Abteilung Neurophysiologie, Max Planck Institut für Hirnforschung, 60528 Frankfurt, Germany
    J Physiol 536:429-37. 2001
    ..Since such changes were shown to be Ca2+ dependent, we propose that GABA-evoked Ca2+ signalling is one of the critical determinants for the normal development of cerebellar PNs...
  31. pmc Do cross-modal projections always result in multisensory integration?
    Brian L Allman
    Department of Anatomy and Neurobiology, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA
    Cereb Cortex 18:2066-76. 2008
  32. ncbi Spontaneous network activity in the embryonic spinal cord regulates AMPAergic and GABAergic synaptic strength
    Carlos Gonzalez-Islas
    Department of Physiology, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
    Neuron 49:563-75. 2006
    ..Because spontaneous network activity can regulate AMPAergic and GABAergic synaptic strength during development, SNA is likely to play an important role in a coordinated maturation of excitatory and inhibitory synaptic strength...
  33. ncbi Critical periods for experience-dependent synaptic scaling in visual cortex
    Niraj S Desai
    Department of Biology and Volen National Center for Complex Systems, MS 008, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA
    Nat Neurosci 5:783-9. 2002
  34. ncbi GABA and its agonists improved visual cortical function in senescent monkeys
    Audie G Leventhal
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Science 300:812-5. 2003
    ..Many treated cells in area V1 of old animals displayed responses typical of young cells. The present results have important implications for the treatment of the sensory, motor, and cognitive declines that accompany old age...
  35. pmc Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors
    Jason D Shepherd
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 52:475-84. 2006
    ..1 is required for memory consolidation, reveal the importance of Arc/Arg3.1's dynamic expression as it exerts continuous and precise control over synaptic strength and cellular excitability...
  36. ncbi Effects of electrically coupled inhibitory networks on local neuronal responses to intracortical microstimulation
    Sergejus Butovas
    Hertie Institute for Clinical Brain Research, Department of Cognitive Neurology, University Tübingen, Otfried Müller Str 27, 72076 Tubingen, Germany
    J Neurophysiol 96:1227-36. 2006
    ..Electrical coupling renders evoked cortical inhibition more precise and strong and ensures a uniform spread along the two cardinal axes of neocortical geometry...
  37. ncbi The role of activity-dependent network depression in the expression and self-regulation of spontaneous activity in the developing spinal cord
    J Tabak
    Laboratory of Neural Control, Section on Developmental Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 21:8966-78. 2001
    ..Specifically, we show how they follow logically from a bistable network with a slow activity-dependent depression switching periodically between the active and inactive states...
  38. pmc A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons
    Collin J Lobb
    Neurosciences Institute, University of Texas at San Antonio, San Antonio, Texas 78249, USA
    J Neurophysiol 104:403-13. 2010
    ..These results support a bidirectional mechanism by which GABAergic inputs, in balance with NMDA receptor-mediated excitatory inputs, control the firing pattern of dopaminergic neurons...
  39. ncbi Taurine activates strychnine-sensitive glycine receptors in neurons freshly isolated from nucleus accumbens of young rats
    Zhenglin Jiang
    Departments of Anesthesiology, Pharmacology, and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    J Neurophysiol 91:248-57. 2004
    ..By activating GlyRs, taurine may play an important physiological role in the control of NAcc function, especially during development...
  40. pmc Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities
    Stephen H Hadley
    Department of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    J Physiol 581:1001-18. 2007
    ..The possibility that the high affinity state of the alpha6beta2delta receptor modulates the granule neuron activity as well as potential mechanisms affecting its expression are discussed...
  41. ncbi High-frequency organization and synchrony of activity in the purkinje cell layer of the cerebellum
    Camille de Solages
    Laboratoire de Neurobiologie, UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Neuron 58:775-88. 2008
    ..Convergence in the deep cerebellar nuclei of Purkinje cell activity, synchronized by these oscillations, likely organizes temporally the cerebellar output...
  42. pmc Studies on the mechanisms of action of picrotoxin, quercetin and pregnanolone at the GABA rho 1 receptor
    Juan D Goutman
    Departamento de Fisiologia, Biologia Molecular y Celular, Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Universidad de Buenos Aires, Republica Argentina
    Br J Pharmacol 141:717-27. 2004
    ..9. The effect of pregnanolone was use-independent, presented fast onset and a very slow washout, and did not affect current activation. 10. All the antagonists accelerated the time course of deactivation of the GABA rho(1) currents...
  43. ncbi Gain modulation of respiratory neurons
    Edward J Zuperku
    Research Service 151, Zablocki VA Medical Center, Milwaukee, WI 53295, USA
    Respir Physiol Neurobiol 131:121-33. 2002
    ..g. coughing, sneezing, vomiting) mediated by respiratory premotor neurons...
  44. pmc Optical imaging of spatiotemporal patterns of glutamatergic excitation and GABAergic inhibition in the guinea-pig auditory cortex in vivo
    J Horikawa
    Department of Neurophysiology, Tokyo Medical and Dental University, Japan
    J Physiol 497:629-38. 1996
  45. ncbi Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection
    Sofia Papadia
    Centre for Neuroscience Research, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
    J Neurosci 25:4279-87. 2005
    ..Thus, activity-dependent neuroprotection comprises two mechanistically distinct phases that differ in their spatial requirements for calcium and in their reliance on the CREB family...
  46. ncbi Excitatory and inhibitory control of epileptiform discharges in combined hippocampal/entorhinal cortical slices
    L Menendez de la Prida
    Brain Mapping Unit, Instituto Pluridisciplinar, Universidad Complutense de Madrid, Paseo Juan XXIII 1, 28040, Madrid, Spain
    Brain Res 940:27-35. 2002
    ..Based on these regional differences, we show that epileptiform activity can be pharmacologically isolated within the CA1 region in the hippocampal-entorhinal circuitry in vitro...
  47. ncbi GABAergic regulation of the central nucleus of the amygdala: implications for sleep control
    Larry D Sanford
    Sleep Research Laboratory, Department of Pathology and Anatomy, Eastern Virginia Medical School, PO Box 1980, Norfolk, VA 23501, USA
    Brain Res 956:276-84. 2002
    ..These findings demonstrate that inactivating CNA can produce a relatively selective suppression of REM. The possible role that spontaneous activity in CNA may play in REM initiation and/or maintenance is discussed...
  48. ncbi Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus
    Annalisa Scimemi
    Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 25:10016-24. 2005
    ..The relative contribution of these components changes after the induction of epilepsy, implying an adaptive plasticity of the tonic current in the presence of spontaneous seizures...
  49. ncbi Mixed antagonistic effects of bilobalide at rho1 GABAC receptor
    S H Huang
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology D06, Faculty of Medicine, The University of Sydney, NSW 2006, Australia
    Neuroscience 137:607-17. 2006
    ..The mechanism of action of bilobalide at rho(1) GABA(C) receptors appears to be similar to that of the chloride channel blocker picrotoxinin...
  50. ncbi Distribution of anxiogenic-induced c-Fos in the forebrain regions of developing rats
    A Kurumaji
    Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Neural Transm 110:1161-8. 2003
    ..These differences in the regional distribution of a neuronal activity marker, c-Fos, could reflect the postnatal development of neuronal populations or neuron circuits involved in stress and/or emotional response in the forebrain...
  51. ncbi Relative impact of residues at the intracellular and extracellular ends of the human GABAC rho1 receptor M2 domain on picrotoxinin activity
    Jane E Carland
    Faculty of Pharmacy, A15, The University of Sydney, NSW 2006, Australia
    Eur J Pharmacol 580:27-35. 2008
  52. pmc Endogenous GABA and glutamate finely tune the bursting of olfactory bulb external tufted cells
    Abdallah Hayar
    Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurophysiol 98:1052-6. 2007
    ..We suggest that ET cell excitatory and inhibitory inputs may be encoded as a change in the pattern of spike bursting in ET cells, which together with mitral/tufted cells constitute the output circuit of the olfactory bulb...
  53. ncbi Baclofen into the lateral parabrachial nucleus induces hypertonic sodium chloride and sucrose intake in rats
    L B de Oliveira
    Department of Physiology and Pathology, School of Dentistry, Sao Paulo State University, UNESP, Araraquara, Sao Paulo, Brazil
    Neuroscience 183:160-70. 2011
    ..The natriorexigenic effect is not secondary to alterations in blood pressure or sodium urinary excretion. In addition, baclofen injected into the LPBN also induces 0.06 M sucrose intake...
  54. pmc Enhancement by GABA of the association rate of picrotoxin and tert-butylbicyclophosphorothionate to the rat cloned alpha 1 beta 2 gamma 2 GABAA receptor subtype
    G H Dillon
    CNS Diseases Research, Upjohn Company, Kalamazoo, MI 49001, USA
    Br J Pharmacol 115:539-45. 1995
    ..This and our earlier study with U-93631 improves our understanding of functional coupling between GABA and picrotoxin sites, which appears to be useful in characterizing the mode of interaction for various picrotoxin site ligands...
  55. pmc Differences in spike train variability in rat vasopressin and oxytocin neurons and their relationship to synaptic activity
    Chunyan Li
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Physiol 581:221-40. 2007
    ..For example, the increased firing variability that precedes bursting in OT neurons during lactation could be related to significant changes in synaptic activity...
  56. ncbi Decoding NMDA receptor signaling: identification of genomic programs specifying neuronal survival and death
    Sheng Jia Zhang
    Department of Neurobiology, Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, 69120 Heidelberg, Germany
    Neuron 53:549-62. 2007
    ..They also demonstrate that the survival function is implemented in neurons through a multicomponent system of functionally related genes, whose coordinate expression is controlled by specific calcium signal initiation sites...
  57. ncbi Neither GABA(A) nor strychnine-sensitive glycine receptors are the sole mediators of MAC for isoflurane
    Y Zhang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143-0464, USA
    Anesth Analg 92:123-7. 2001
    ..They are not, however, the only receptors that contribute to isoflurane-induced immobility (i.e., that determine the MAC of isoflurane)...
  58. pmc Hibernation induces pentobarbital insensitivity in medulla but not cortex
    Keith B Hengen
    School of Veterinary Medicine, University of Wisconsin, Madison, Madison, Wisconsin 53706, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1028-36. 2009
    ..We hypothesize that GABA(A) receptors undergo a seasonal modification in subunit composition, such that cardiorespiratory neurons are uniquely unaffected by surges of an endogenous positive allosteric modulator...
  59. ncbi Mechanism of irregular firing of suprachiasmatic nucleus neurons in rat hypothalamic slices
    Nikolai I Kononenko
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurophysiol 91:267-73. 2004
    ..Thus GABAA receptor-mediated IPSPs appear responsible for irregular firing of SCN neurons in hypothalamic slices...
  60. ncbi Picrotoxin-mediated antagonism of alpha3beta4 and alpha7 acetylcholine receptors
    Brian E Erkkila
    Department of Neurobiology, University of Alabama at Birmingham School of Medicine, 1719 6th Ave South CIRC 410, Birmingham, AL 35294, USA
    Neuroreport 15:1969-73. 2004
    ..Furthermore they should also be considered when employing PTX to selectively eliminate GABA- or glycine-mediated events...
  61. ncbi Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABA(A) receptors
    Michaela Scheller
    Klinik fuer Anaesthesiologie der Technischen Universitaet Muenchen, Klinikum rechts der Isar, D 81675 Munich, Germany
    J Neurosci 22:8411-21. 2002
    ..The effects of the alpha1(L264T) mutation suggest that the conserved leucines may play a role in gating-desensitization coupling...
  62. ncbi A PET study following treatment with a pharmacological stressor, FG7142, in conscious rhesus monkeys
    Hiroyuki Takamatsu
    The Medical and Pharmacological Research Center Foundation, Wo32, Inoyama Town, Hakui City, Ishikawa 925 0613, Japan
    Brain Res 980:275-80. 2003
  63. ncbi Kinetics and spontaneous open probability conferred by the epsilon subunit of the GABAA receptor
    David A Wagner
    Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin 53201, USA
    J Neurosci 25:10462-8. 2005
    ..In addition, silencing of spontaneous openings by desensitization raises the possibility that tonic inhibition mediated by epsilon-containing receptors may be regulated by phasic inhibition...
  64. ncbi Resistance to fipronil in Drosophila simulans: influence of two point mutations in the RDL GABA receptor subunit
    Gaelle Le Goff
    UMR 1112, INRA Université de Nice Sophia Antipolis, Sophia Antipolis, France
    J Neurochem 92:1295-305. 2005
    ..In conclusion, the present study emphasizes new aspects of the pharmacological alterations induced by the Rdl mutation and shows that resistance to GABA receptor-directed insecticides may implicate a mutation distinct from Rdl...
  65. pmc Propofol inhibits pressure-stimulated macrophage phagocytosis via the GABAA receptor and dysregulation of p130cas phosphorylation
    Hiroe Shiratsuchi
    John D Dingell Veterans Affairs Medical Center, Detroit, Michigan, USA
    Am J Physiol Cell Physiol 296:C1400-10. 2009
    ..p130cas may be an important target for modulation of macrophage function in anesthetized patients...
  66. ncbi Non-competitive GABA antagonists: probing the mechanisms of their selectivity for insect versus mammalian receptors
    Y Ozoe
    Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane 690 8504, Japan
    Pest Manag Sci 57:923-31. 2001
    ..This revealed several important differences that might be related to the selectivity of antagonists between the structures of the non-competitive antagonist-binding sites of housefly and rat GABA receptors...
  67. ncbi Blanes cells mediate persistent feedforward inhibition onto granule cells in the olfactory bulb
    R Todd Pressler
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Neuron 49:889-904. 2006
    ..Persistent firing in Blanes cells may represent a novel mechanism for encoding short-term olfactory information through modulation of tonic inhibitory synaptic input onto bulbar neurons...
  68. ncbi Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs
    Nicolas Singewald
    Department of Pharmacology and Toxicology, University of Innsbruck, Innsbruck, Austria
    Biol Psychiatry 53:275-83. 2003
    ..The fact that induction of anxiety- and panic-related symptoms is a property common to a range of drugs suggests that common neural substrates underlie their behavioral effects...
  69. pmc Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia
    Wanling Zhu
    Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar St, New Haven, CT, USA
    Am J Physiol Endocrinol Metab 298:E971-7. 2010
  70. ncbi Normal patterns of spontaneous activity are required for correct motor axon guidance and the expression of specific guidance molecules
    M Gartz Hanson
    Department of Neurosciences, Case School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Neuron 43:687-701. 2004
    ..More prolonged (E2-5) blockade resulted in a downregulation of LIM homeodomain transcription factors, but since this occurred only after the pathfinding errors and alterations in guidance molecules, it cannot have contributed to them...
  71. ncbi Relationship between excitation and inhibition underlying size tuning and contextual response modulation in the cat primary visual cortex
    Hirofumi Ozeki
    School of Health and Sport Sciences, Osaka University, Toyonaka, Osaka 560 0043, Japan
    J Neurosci 24:1428-38. 2004
  72. ncbi Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome
    Fabian Fernandez
    Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, Palo Alto, California 94304 5485, USA
    Nat Neurosci 10:411-3. 2007
    ..These results suggest that over-inhibition contributes to intellectual disabilities associated with Down syndrome and that GABAA antagonists may be useful therapeutic agents for this disorder...
  73. ncbi GABA(B) receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses
    Hervé Fiorentino
    Institut de Neurobiologie de la Mediterranee, Institut National de la Sante et de la Recherche Medicale, Unité 901, and Université de la Méditerranée, 13273 Marseille Cedex 09, France
    J Neurosci 29:11650-61. 2009
  74. pmc GABAA transmission is a critical step in the process of triggering homeostatic increases in quantal amplitude
    Jennifer C Wilhelm
    Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 105:11412-7. 2008
    ..Therefore, GABA appears to be serving as a proxy for activity levels...
  75. ncbi Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane
    Yi Zhang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 99:85-90. 2004
    ..This supports the view that GABAA receptors do not mediate immobilization for isoflurane...
  76. ncbi Active roles of electrically coupled bipolar cell network in the adult retina
    Itaru Arai
    Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Neurosci 30:9260-70. 2010
    ..These results suggest that the spread of Ca(2+) spikes through gap junctions between bipolar cells may play a key role in lateral interactions in the adult retina...
  77. pmc Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs
    Court Hull
    Neurobiology Section, Division of Biology, School of Medicine, University of California, San Diego, La Jolla, California 92093 0634, USA
    J Neurosci 29:9127-36. 2009
    ..Thus, thalamic afferent activity diverges into two routes that rely on unique complements of postsynaptic AMPARs and NMDARs to orchestrate the dynamic balance of excitation and inhibition as sensory input enters the cortex...
  78. ncbi Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors
    Shelley H Huang
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, Faculty of Medicine, The University of Sydney, Sydney, NSW 2006, Australia
    Eur J Pharmacol 494:131-8. 2004
    ..Antagonism by these ginkgolides at alpha(1)beta(2)gamma(2L) GABA(A) receptors appears to be noncompetitive as indicated by the nonparallel right shift and reduced maximal GABA response in their GABA concentration-effect curves...
  79. ncbi Glucose-dependent regulation of gamma-aminobutyric acid (GABA A) receptor expression in mouse pancreatic islet alpha-cells
    Sarah J Bailey
    Henry Wellcome Laboratories for Integrated Cell Signaling, and Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK
    Diabetes 56:320-7. 2007
  80. ncbi Structure and function of GABA(C) receptors: a comparison of native versus recombinant receptors
    D Zhang
    Center for Neuroscience and Aging, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Pharmacol Sci 22:121-32. 2001
    ..Finally, GABA(C) receptors play a unique functional role in retinal signal processing via three mechanisms: (1) slow activation; (2) segregation from other inhibitory receptors; and (3) contribution to multi-neuronal pathways...
  81. pmc Structural model for gamma-aminobutyric acid receptor noncompetitive antagonist binding: widely diverse structures fit the same site
    Ligong Chen
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy, and Management, College of Chemistry, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 103:5185-90. 2006
    ..Thus, widely diverse NCA structures fit the same GABA receptor beta subunit site with important implications for insecticide cross-resistance and selective toxicity between insects and mammals...
  82. ncbi Graded response to GABA by native extrasynaptic GABA receptors
    Catarina E L Lindquist
    School of Medicine, Lund University, Lund, Sweden
    J Neurochem 97:1349-56. 2006
  83. ncbi Excitatory GABA action is essential for morphological maturation of cortical neurons in vivo
    Laura Cancedda
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, California 94720 3200, USA
    J Neurosci 27:5224-35. 2007
    ..Thus, membrane depolarization caused by early GABA excitation is critical for morphological maturation of neonatal cortical neurons in vivo...
  84. ncbi Neuroendocrine, behavioral and macrophage activity changes induced by picrotoxin effects in mice
    D Stankevicius
    Department of Pharmacology, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, SP, Brazil
    Neuropharmacology 54:300-8. 2008
    ..These facts suggest that this chemical stressor triggers CNS pathways that might be somehow different from those fired by inescapable foot-shock and psychological stressors, leading to different neuro-innate immune responses...
  85. ncbi GABA-mediated oxytocinergic inhibition in dorsal horn neurons by hypothalamic paraventricular nucleus stimulation
    Gerardo Rojas-Piloni
    Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus UNAM Juriquilla, Queretaro, Mexico
    Brain Res 1137:69-77. 2007
    ..We discuss our observation that the PVN electrical stimulation selectively inhibits Adelta and C-fiber activity without affecting Abeta fibers. We conclude that Adelta and C-fibers receive a presynaptic inhibition mediated by GABA...
  86. pmc Development of multisensory convergence in the Xenopus optic tectum
    Katherine E Deeg
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    J Neurophysiol 102:3392-404. 2009
  87. ncbi Synchronization of olfactory bulb mitral cells by precisely timed inhibitory inputs
    Nathan E Schoppa
    Department of Physiology and Biophysics, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    Neuron 49:271-83. 2006
    ..These results demonstrate that rapid synchrony can emerge in a network through the precise back-and-forth interplay between neuronal populations...
  88. pmc Picrotoxin-like channel blockers of GABAA receptors
    Richard W Olsen
    Department of Molecular and Medical Pharmacology, Geffen School of Medicine, University of California, Los Angeles, CA 90095 1735, USA
    Proc Natl Acad Sci U S A 103:6081-2. 2006
  89. ncbi Cross-modal circuitry between auditory and somatosensory areas of the cat anterior ectosylvian sulcal cortex: a 'new' inhibitory form of multisensory convergence
    Lisa R Dehner
    Department of Health Sciences, Physical Therapy Program, College of Mount St Joseph, Cincinnati, OH 45233, USA
    Cereb Cortex 14:387-403. 2004
    ..This form of excitatory-inhibitory multisensory convergence has not been reported before and suggests that the level of interaction between auditory and somatosensory modalities has been substantially underestimated...
  90. ncbi GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine
    Zheng Xiong Xi
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 23:3498-505. 2003
    ..The increase may be mediated in part by functional desensitization of GABA(B) receptors, likely the result of diminished Ser phosphorylation of the GABA(B2) receptor...
  91. ncbi Expansion of receptive fields in motor cortex by local blockade of GABAA receptors
    Charles Capaday
    Department of Anatomy and Physiology, CRULRG Brain and Movement Laboratory, Quebec, Canada
    Exp Brain Res 153:118-22. 2003
    ..The role of local inhibitory control of sensory inputs to motor cortex neurons may thus be different than that in sensory cortex where it is thought to restrict receptive field size...
  92. ncbi Development of an inhibitory interneuronal circuit in the embryonic spinal cord
    Huaying Xu
    Department of Physiology, Emory University, School of Medicine, Atlanta, GA 30340, USA
    J Neurophysiol 93:2922-33. 2005
    ..The R-interneuron projects three or more segments both rostrally and caudally through the ventrolateral funiculus. The distribution of this circuit may become more locally focused between E7.5 and E15...
  93. ncbi Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression
    S C Baraban
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, Box 0520, 503 Parnassus Avenue, San Francisco, CA 94143, USA
    Neuroscience 131:759-68. 2005
    ..Therefore, zebrafish larvae represent a powerful new system to study the underlying basis of seizure generation, epilepsy and epileptogenesis...
  94. ncbi Taurine activates strychnine-sensitive glycine receptors in neurons of the rat inferior colliculus
    Han Xu
    Department of Neurobiology and Biophysics, School of Life Sciences, University of Science and Technology of China, PO Box 4, Hefei 230027, China
    Brain Res 1021:232-40. 2004
    ..These findings indicate that Tau activates glycine receptors in neurons of the rat IC and thus may have a functional role in regulating or modulating the neurotransmission of the central auditory system in mammals...
  95. pmc The supramammillary nucleus mediates primary reinforcement via GABA(A) receptors
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Neuropsychopharmacology 30:1088-95. 2005
    ..In conclusion, the blockade of GABA(A) receptors in the SUM is reinforcing, and the brain 'reward' circuitry appears to be tonically inhibited via supramammillary GABA(A) receptors and more extensive than the meso-limbic dopamine system...
  96. ncbi Fundamental differences in spontaneous synaptic inhibition between deep and superficial layers of the rat entorhinal cortex
    Gavin L Woodhall
    Department of Physiology and MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    Hippocampus 15:232-45. 2005
    ..The results are discussed in terms of the overall level of background inhibition in the two layers, as well as how this might relate to their susceptibilities to epileptogenesis...
  97. ncbi Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn
    Hiroshi Baba
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell Neurosci 24:818-30. 2003
    ..This NMDA receptor-dependent phenomenon may contribute to bicuculline-induced allodynia or hyperalgesia, as well as the hypersensitivity observed in neuropathic pain patients...
  98. ncbi Effects of GABA receptor antagonists on retinal glycine receptors and on homomeric glycine receptor alpha subunits
    Peiyuan Wang
    Dept of Physiology and Biophysics, 124 Sherman Hall, Buffalo, NY 14214, USA
    J Neurophysiol 93:3120-6. 2005
    ..In examining retinal glycine receptors, we were surprised to find that commonly used concentrations of GABA antagonists blocked significant fractions of the glycine current...
  99. ncbi Release from GABA(A) receptor-mediated inhibition unmasks interlaminar connection within superior colliculus in anesthetized adult rats
    Hideyuki Katsuta
    Graduate University for Advanced Studies, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8585, Japan
    Neurosci Res 46:73-83. 2003
    ..We propose that sSC is the main candidate for the source of the excitatory synaptic inputs to dSC among the subcortical regions...
  100. ncbi Cortical inhibitory circuits in eye-movement generation
    Peter H Schiller
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Eur J Neurosci 18:3127-33. 2003
    ..Inhibitory circuits in the LIP do not appear to play a central role in target selection and in visual discrimination...
  101. ncbi Neuronal activity regulates GABAA receptor subunit expression in organotypic hippocampal slice cultures
    I E Holopainen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, PharmaCity, Itainen Pitkakatu 4, FIN 20520, Turku, Finland
    Neuroscience 118:967-74. 2003

Research Grants63

    MICHAEL NMN DAVIS; Fiscal Year: 2010
    ..Finally, we will employ a discrimination procedure we developed to determine or GABA antagonists or inactivation of the hippocampus, septal nucleus, bed nucleus stria terminalis or frontal cortex will ..
  2. Vasopressin in the regulation of serotonin and anxiety
    BENJAMIN DAVID ROOD; Fiscal Year: 2013
    ..abstract_text> ..
  3. Limbic-Basal Ganglia Circuitry in PTSD
    Ludise Malkova; Fiscal Year: 2013
  4. Basal Ganglia and Higher Cortical Function
    Peter L Strick; Fiscal Year: 2012
    ..This information may lead to new avenues for treatment of complex disorders like Depression, OCD and TS. ..
  5. Anatomical and Physiological Characterization of the Thalamostriatal System
    KALYNDA GONZALES; Fiscal Year: 2012
    ..The results will also be relevant for our understanding of the mechanisms underlying the therapeutic effects of CM/PF DBS in movement disorders. ..
  6. Cortical connections with the limbic territory of the basal ganglia
    Michelle Morrow; Fiscal Year: 2007
    ..This information may result in new avenues for treatment of complex disorders like OCD and TS. [unreadable] [unreadable] [unreadable]..
  7. The Nucleus Accumbens as a Behavioral Switchboard
    Gwendolyn G Calhoon; Fiscal Year: 2012
    ..MSNs in the NA will be recorded during PFC and HP stimulation in the presence and absence of GABA antagonists. In separate experiments, synchronicity between NA and PFC versus HP local field potentials will be evaluated ..
    Emanuel Meller; Fiscal Year: 1993
    ..g. Parkinson's disease and schizophrenia). Furthermore, the results may lead to fruitful new strategies for treatment of these and related disorders...
  9. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2006
    ..abstract_text> ..
    Timothy M Miller; Fiscal Year: 2013
    ..In addition, using measures of neuronal excitability in response to GABA antagonists, we will correlated the amount of tau knockdown and shift from 4R to 3R with the change in neuronal ..
  11. Effects of acupuncture on chemotherapy-induced pain
    Ruixin Zhang; Fiscal Year: 2009
    ..This study will evaluate the effects and mechanisms of electroacupuncture (EA) on such pain in a rat model. The success of the proposed study will greatly advance the management of CIP. ..
    John Peluso; Fiscal Year: 2001
    ..As such, these putative antagonists/agonist could find applications in the treatment of ovarian cancers, infertility and premature ovarian failure. ..
    BANG HWANG; Fiscal Year: 1991
    ..These studies may provide new information on the neural basis of hypertension associated with GABA/VP neurons, which will be useful for drug developments aimed at the treatment or prevention of hypertension...
  14. Retinal Inhibitory Glycine Receptors
    Malcolm Slaughter; Fiscal Year: 2007
    ..Another is to characterize GABA receptor antagonists which interact with the glycine receptor. These specific aims are a necessary first step in unraveling inhibitory synapses in retina. ..
    CHRISTINE MELCHIOR; Fiscal Year: 1992
    ..Cross-tolerance or sensitivity to the effects of the steroids will also be determined after withdrawal signs have terminated...
    NOOR ALAM; Fiscal Year: 2003
    ..Adenosine and GABA antagonists will partially attenuate changes in neuronal discharge and excitability that occur during sleep deprivation ..
    EUGENE BARNES; Fiscal Year: 1993
    ..Possible up-regulation by benzodiazepine antagonists and reverse agonists, as well as GABA antagonists, will also be evaluated. 2...
    Judith Richter; Fiscal Year: 1990
    ..the effects of other GABAergic drugs and by determining if the effect of barbiturates can be reversed by GABA antagonists or local GABA depletion...
    William Renehan; Fiscal Year: 2001
    ..We believe that the studies proposed in this application will yield significant and novel data regarding the development of inhibitory circuits in the central nervous system. ..
  20. Discriminative Stimulus Effects of Alcohol in Mice
    Wouter Koek; Fiscal Year: 2007
    ..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. [unreadable] [unreadable] [unreadable]..
  21. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2010
    ..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
  22. Northeast Under/Grad Research Organization for Neuroscience
    Cheryl Frye; Fiscal Year: 2008
    ..Both of these outcomes are congruous with the Public Health Service's mission to ensure that there is a resource of well-trained scientists and health-care providers in the United States. [unreadable] [unreadable] [unreadable]..
  23. MOP Receptor Effects on the Hippocampal CA1 Network
    ADAM MCQUISTON; Fiscal Year: 2008
    ..The results from these studies will provide important information regarding MOP receptor-induced changes in network activity and may possibly lead to the development of treatments for opioid addiction. ..
    Carl Faingold; Fiscal Year: 2002
    ..We expect these approaches to yield novel insights into the neurobiological mechanisms controlling seizure susceptibility during ethanol withdrawal and suggest improved approaches to the therapy of alcoholism. ..
  25. The Role of Areas V1 and V2 in Target Selection
    Peter Schiller; Fiscal Year: 2008
    ..abstract_text> ..
  26. RNAi-medicated inhibition of BDNF expression and alcohol-drinking behavior
    QINGSHAN YAN; Fiscal Year: 2008
    ..abstract_text> ..
    QINGSHAN YAN; Fiscal Year: 2002
    ..This will elucidate the relative contribution of 5-HT2 receptors to the regulation of ethanol-induced DA release and help to explain the effects of 5-HT2 antagonists on alcohol consumption reported in the literature. ..
    LARRY SANFORD; Fiscal Year: 2009
  29. Preventing spike-wave epileptogenesis: critical periods & neuroimaging biomarkers
    Hal Blumenfeld; Fiscal Year: 2010
    ..untreated animals. We will also investigate the anatomical basis of white matter DTI abnormalities through electron microscopy to determine changes in axons and myelin in affected regions. 2. ..
  30. Axonal Signaling in the Hippocampus
    Steven J Mennerick; Fiscal Year: 2010
    ..Our results will also lead to cellular insights into the mechanism of brain stimulation techniques currently used in the treatment of movement disorders and neuropsychiatric disease. ..
    ROBERT SLOVITER; Fiscal Year: 2006
    ..abstract_text> ..
  32. Viral Encephalitis, Chemokines and Sleep
    LARRY D contact SANFORD; Fiscal Year: 2010
    ..Such understanding may provide insight that could lead to improved therapies and improved prognosis for infectious diseases. ..
    Stephen Johnson; Fiscal Year: 2001
    LARRY SANFORD; Fiscal Year: 2001
    ..These studies may lead to a better understanding of disorders of REM, such as REM behavior disorder, which, like REM-A, is characterized by overt behavior during sleep. ..
  35. Contribution of the PAG to morphine tolerance
    Michael Morgan; Fiscal Year: 2002
    ..In the long term, such knowledge should improve the treatment of pain by allowing therapies that disrupt tolerance to be developed. ..
  36. Coupling & Reconfiguration of Rhythmic Motor Networks
    Stephen Johnson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  37. In Vitro Mechanisms of Ethanol Induced Neuronal Death.
    Steven Mennerick; Fiscal Year: 2005
    ..The proposed experiments should lead to a better fundamental understanding of the mechanisms by which forebrain neurons are susceptible to ethanol-induced death. ..
  38. Retinal Synaptic Transmission: Channels and Transmitters
    Zhuo Hua Pan; Fiscal Year: 2005
    ..The understanding of the role of voltage-activated Ca2+ channels in synaptic transmission may also provide insight for identifying the mechanism of diseases caused by synaptic dysfunction. ..
  39. Control of Synaptic Glutamate Release
    Steven Mennerick; Fiscal Year: 2004
    ..In addition, we expect our results to elucidate details of the mechanisms of action potential coupling to chemical neurotransmission and a possible mechanism of synaptic plasticity. ..
  40. Expression & function of channelrhodopsins in the retina
    Zhuo Hua Pan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
    NORMAN RUBY; Fiscal Year: 2004
    ..We chose to focus on melatonin because its effects on the circadian system of Siberian hamsters suggest a role for this hormone in entrainment. ..
    Peter Schiller; Fiscal Year: 2002
    ..The proposed work has important clinical relevance as it will serve characterize the functions of various visual cortical areas. ..
    Peter Schiller; Fiscal Year: 2007
    ..abstract_text> ..
  44. Noninvasive monitoring of physiological parameters in mice
    LARRY SANFORD; Fiscal Year: 2008
    ..The proposed applications have particular significance for studies of behavior and sleep. [unreadable] [unreadable] [unreadable]..
    Hal Blumenfeld; Fiscal Year: 2002
    ..The information provided by these studies may yield insights into the mechanisms of normal cortical rhythmic oscillations, and suggest new therapies for the therapeutic management of epileptic seizures. ..
  46. Cue-Reactivity and Alcohol Self-Dosing
    Elise Weerts; Fiscal Year: 2003
    ..This research will additionally provide important information on the behavioral processes underlying conditioned responses to drug-related cues in animals which may be relevant to cue-reactivity and drug-taking in humans. ..
    JOHN MACLENNAN; Fiscal Year: 2001
    ..In addition to greatly expanding the current understanding of CNTFRa's role in spinal motor neuron survival and regeneration, the proposed experiments will constitute the first direct in vivo examination of adult CNTFRa function. ..
    Robert E Hampson; Fiscal Year: 2010
    ..abstract_text> ..
  49. Prenatal Corticosteroid Impact on Hippocampus
    LIBOR VELISEK; Fiscal Year: 2004
    ..The data of this proposal will be critical for determining long-term adverse effects of multiple course prenatal corticosteroid therapy and for the ameliorating these effects in the offspring. ..
    Linda Hayward; Fiscal Year: 2002
    ..In the long term it is hoped that the results of these studies will stimulate new investigations into the role of the dlPAG, A5 and the PBN in normal and pathophysiological cardiovascular regulation. ..
    Peter Kalivas; Fiscal Year: 2003
    ..Furthermore, the anatomical and functional mapping of the motive circuit will provide a basis for interpreting future imaging studies in humans where attempts are made to correlate changes in spatially discrete nuclei. ..
    John Swann; Fiscal Year: 2007
    ..Since there are so few animal models of early-onset epilepsy, the studies proposed here offer a unique opportunity to further an understanding of the biological origins of seizure disorders in infancy. ..
    Robert Hampson; Fiscal Year: 2004
  54. Dopamine Effects On Memory Consolidation
    Ryan LaLumiere; Fiscal Year: 2004
    ..These findings may provide insight into disorders of memory, such as posttraumatic stress disorder, as well as into the connections between emotionally influenced memory consolidation and addiction processes. ..
  55. Locomotion Control by Lumbar Spinal Cord Stimulation
    Changfeng Tai; Fiscal Year: 2008
    ..The proposed studies will not only improve our understanding of locomotion control in lumbar spinal cord but also benefit SCI patients. ..
  56. Dynamic Neuronal Organizations in Neocortex
    Jian Young Wu; Fiscal Year: 2008
    ..S. population. ..
    Stephen Schneider; Fiscal Year: 2007
    ..The studies will provide essential information about dynamic modulation of synaptic function underlying spinal integration of innocuous and noxious sensory information. ..
    Kevin Davis; Fiscal Year: 2006
    ..abstract_text> ..
  59. Cortico-Amygdalo-Thalamic Circuitry in Humans
    Sabina Berretta; Fiscal Year: 2007
    ..More in general, results obtained from the investigations described in this proposal will be relevant to the study of the physiological functions of AMYG and of its role in major psychiatric diseases. ..
  60. Alcohol Modulation of Cerebellar Synaptic Currents
    William Proctor; Fiscal Year: 2006
    ..The combination of our proposed and ongoing genetic studies may aid the identification of more sensitive drug targets and the development of novel drugs for rational therapeutic approaches to alcoholism. ..
  61. Can beta-lactam antibiotics decrease morphine physical dependence?
    SCOTT RAWLS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  62. Mechanisms of Signal Transduction of GHB Action
    Godfrey Tunnicliff; Fiscal Year: 2002
    ..In turn, this will help to develop therapeutic and preventive strategies resulting in a lessened abuse potential of GHB. ..
  63. Hypocretin Neurons
    Anthony N van den Pol; Fiscal Year: 2010
    ..Understanding the role of the endogenous opioid in hypocretin cells should also facilitate the understanding and treatment of narcolepsy. ..