gaba agonists

Summary

Summary: Drugs that bind to and activate GAMMA-AMINOBUTYRIC ACID receptors (RECEPTORS, GABA).

Top Publications

  1. pmc Developmental regulation and neuroprotective effects of striatal tonic GABAA currents
    V Santhakumar
    Departments of Neurology and Physiology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Neuroscience 167:644-55. 2010
  2. pmc Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors
    Valerie B Caraiscos
    Institute of Medical Science, Department of Anesthesia, University of Toronto, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 101:3662-7. 2004
  3. ncbi Activation of GABAA receptors: views from outside the synaptic cleft
    Joseph Glykys
    Interdepartmental PhD Program for Neuroscience, The David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Neuron 56:763-70. 2007
  4. ncbi Plasma and CNS concentrations of Gaboxadol in rats following subcutaneous administration
    Thomas Cremers
    Brains on Line, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Eur J Pharmacol 562:47-52. 2007
  5. ncbi Highway driving performance and cognitive functioning the morning after bedtime and middle-of-the-night use of gaboxadol, zopiclone and zolpidem
    Tim R M Leufkens
    Experimental Psychopharmacology Unit, Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    J Sleep Res 18:387-96. 2009
  6. ncbi Baclofen enhances extinction of opiate conditioned place preference
    S C Heinrichs
    Research Service VA Boston Healthcare System, Boston, MA, USA
    Behav Brain Res 207:353-9. 2010
  7. ncbi Nucleus accumbens opioid, GABaergic, and dopaminergic modulation of palatable food motivation: contrasting effects revealed by a progressive ratio study in the rat
    Min Zhang
    Department of Psychiatry, University of Wisconsin Madison Medical School, 53715, USA
    Behav Neurosci 117:202-11. 2003
  8. ncbi The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
    C Rivera
    Department of Biosciences, University of Helsinki, Finland
    Nature 397:251-5. 1999
  9. ncbi Extrasynaptic GABA(A) channels activated by THIP are modulated by diazepam in CA1 pyramidal neurons in the rat brain hippocampal slice
    Catarina E L Lindquist
    Molecular and Cellular Physiology, Department of Physiological Sciences, Lund University, Tornavagen 10 BMC F11, 22184 Lund, Sweden
    Mol Cell Neurosci 24:250-7. 2003
  10. ncbi Sodium intake by hyperosmotic rats treated with a GABA(A) receptor agonist into the lateral parabrachial nucleus
    Everton Heidi Kimura
    Department of Basic Science, School of Dentistry, Sao Paulo State University, UNESP, Rua José Bonifácio 1193, 16015 050, Aracatuba, SP, Brazil
    Brain Res 1190:86-93. 2008

Detail Information

Publications261 found, 100 shown here

  1. pmc Developmental regulation and neuroprotective effects of striatal tonic GABAA currents
    V Santhakumar
    Departments of Neurology and Physiology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Neuroscience 167:644-55. 2010
    ..Our data are consistent with a role for tonic inhibition mediated by GABA(A)R delta subunits in neuroprotection against excitotoxic insults in the adult striatum...
  2. pmc Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors
    Valerie B Caraiscos
    Institute of Medical Science, Department of Anesthesia, University of Toronto, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 101:3662-7. 2004
    ....
  3. ncbi Activation of GABAA receptors: views from outside the synaptic cleft
    Joseph Glykys
    Interdepartmental PhD Program for Neuroscience, The David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Neuron 56:763-70. 2007
    ..These same receptors constitute important and specific targets for various endogenous and exogenous neuroactive compounds and possible therapeutic targets...
  4. ncbi Plasma and CNS concentrations of Gaboxadol in rats following subcutaneous administration
    Thomas Cremers
    Brains on Line, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Eur J Pharmacol 562:47-52. 2007
    ..It is concluded that concentrations of Gaboxadol in the CNS are in a range, which are likely to activate only extrasynaptic (nongamma subunit containing) GABA(A) receptors...
  5. ncbi Highway driving performance and cognitive functioning the morning after bedtime and middle-of-the-night use of gaboxadol, zopiclone and zolpidem
    Tim R M Leufkens
    Experimental Psychopharmacology Unit, Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    J Sleep Res 18:387-96. 2009
    ..Administration later at night is associated with moderately impairing residual effects on driving and psychomotor performance but not on memory...
  6. ncbi Baclofen enhances extinction of opiate conditioned place preference
    S C Heinrichs
    Research Service VA Boston Healthcare System, Boston, MA, USA
    Behav Brain Res 207:353-9. 2010
    ..Baclofen appears to have disrupted reconsolidation of conditioned reward memory during extinction training and might similarly facilitate extinction learning in human opiate addiction...
  7. ncbi Nucleus accumbens opioid, GABaergic, and dopaminergic modulation of palatable food motivation: contrasting effects revealed by a progressive ratio study in the rat
    Min Zhang
    Department of Psychiatry, University of Wisconsin Madison Medical School, 53715, USA
    Behav Neurosci 117:202-11. 2003
    ....
  8. ncbi The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
    C Rivera
    Department of Biosciences, University of Helsinki, Finland
    Nature 397:251-5. 1999
    ..These data support the conclusion that KCC2 is the main Cl- extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain...
  9. ncbi Extrasynaptic GABA(A) channels activated by THIP are modulated by diazepam in CA1 pyramidal neurons in the rat brain hippocampal slice
    Catarina E L Lindquist
    Molecular and Cellular Physiology, Department of Physiological Sciences, Lund University, Tornavagen 10 BMC F11, 22184 Lund, Sweden
    Mol Cell Neurosci 24:250-7. 2003
    ..5-5 microM ) of GABA. The increase in the inhibitory conductance with membrane depolarization permits gradation of the shunt pathway relative to the level of the excitatory input...
  10. ncbi Sodium intake by hyperosmotic rats treated with a GABA(A) receptor agonist into the lateral parabrachial nucleus
    Everton Heidi Kimura
    Department of Basic Science, School of Dentistry, Sao Paulo State University, UNESP, Rua José Bonifácio 1193, 16015 050, Aracatuba, SP, Brazil
    Brain Res 1190:86-93. 2008
    ..3 M NaCl by hyperosmotic cell-dehydrated rats, suggesting that plasma levels of renin or osmolarity do not affect sodium intake after the blockade of LPBN inhibitory mechanisms with muscimol...
  11. pmc Which cue to "want?" Central amygdala opioid activation enhances and focuses incentive salience on a prepotent reward cue
    Stephen V Mahler
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 29:6500-13. 2009
    ..We conclude that opioid neurotransmission in CeA helps determine which environmental stimuli become most "wanted," and how "wanted" they become. This may powerfully guide reward-seeking behavior...
  12. ncbi Gaboxadol--a new awakening in sleep
    Keith A Wafford
    Merck, Sharp and Dohme, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Curr Opin Pharmacol 6:30-6. 2006
    ..This unique mechanism has contributed to our increased understanding of sleep mechanisms, and targeting of this system offers potential advantages over existing insomnia treatments...
  13. ncbi Effects of baclofen on maintenance and reinstatement of intravenous cocaine self-administration in rats
    U C Campbell
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55455 0392, USA
    Psychopharmacology (Berl) 143:209-14. 1999
    ..Recent studies suggest that the GABA(B) receptor agonist, baclofen, may be a useful pharmacotherapy for cocaine abuse...
  14. ncbi γ-aminobutyric acid type A receptors that contain the δ subunit promote memory and neurogenesis in the dentate gyrus
    Paul D Whissell
    Institute of Medical Science, University of Toronto, Ontario, Canada
    Ann Neurol 74:611-21. 2013
    ..Accordingly, we sought to determine whether δGABAA receptors regulate memory behaviors, as well as neurogenesis in the DG...
  15. pmc Medial auditory thalamic input to the lateral pontine nuclei is necessary for auditory eyeblink conditioning
    Hunter E Halverson
    Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
    Neurobiol Learn Mem 93:92-8. 2010
    ..The results provide evidence that the auditory CS pathway necessary for delay eyeblink conditioning includes the MATN-LPN projection and the visual CS pathway includes the MPN...
  16. ncbi GABA(A) receptor activation in the lateral parabrachial nucleus induces water and hypertonic NaCl intake
    J C Callera
    Department of Basic Science, School of Dentistry, Paulista State University, UNESP, Aracatuba, SP, Brazil
    Neuroscience 134:725-35. 2005
    ..Therefore the activation of GABA(A) receptors in the lateral parabrachial nucleus induces strong NaCl intake, a small ingestion of water and pressor responses, without changes on food intake...
  17. ncbi GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors
    N O Dalby
    Pharmacological Research 3, Novo Nordisk, Novo Nordisk Park, 2760, Maalov, Denmark
    Neuropharmacology 39:2399-407. 2000
    ..These findings substantiate and extend previous findings of different effects of selective versus non-selective GABA uptake inhibitors in animal models of epilepsy...
  18. ncbi The GABAB receptor agonist baclofen prevents heroin-induced reinstatement of heroin-seeking behavior in rats
    Maria Sabrina Spano
    Department of Neuroscience, University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy
    Neuropharmacology 52:1555-62. 2007
    ..The present results show that GABA(B) receptor activation may reduce the propensity to resume drug-induced heroin-seeking behavior thus offering a possible approach in maintaining opiate abstinence...
  19. ncbi Synaptic alpha 5 subunit-containing GABAA receptors mediate IPSPs elicited by dendrite-preferring cells in rat neocortex
    Afia B Ali
    Department of Pharmacology, School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Cereb Cortex 18:1260-71. 2008
    ....
  20. pmc Molecular characterization of agonists that bind to an insect GABA receptor
    Ian McGonigle
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    Biochemistry 49:2897-902. 2010
    ..We conclude that the model and docking procedures yield a good model of the insect GABA receptor binding site and the location of agonists within it...
  21. pmc Activation of single heteromeric GABA(A) receptor ion channels by full and partial agonists
    Martin Mortensen
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 557:389-413. 2004
    ....
  22. ncbi Potential roles of GABA receptors in morphine self-administration in rats
    Seong Shoon Yoon
    College of Pharmacy, Yeungnam University, Gyeongsan, South Korea
    Neurosci Lett 428:33-7. 2007
    ..The purpose of this study was to investigate potential roles for GABA agonists in morphine self-administration behavior...
  23. ncbi Differential sensitivity to Zolpidem of IPSPs activated by morphologically identified CA1 interneurons in slices of rat hippocampus
    A M Thomson
    Department of Physiology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    Eur J Neurosci 12:425-36. 2000
    ..Flumazenil, either alone (n = 3), or after Zolpidem, reduced IPSP amplitude to approximately 90% of control, suggesting that alpha4-containing receptors were not involved...
  24. pmc NMDA receptor-dependent processes in the medial prefrontal cortex are important for acquisition and the early stage of consolidation during trace, but not delay eyeblink conditioning
    Kaori Takehara-Nishiuchi
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Japan
    Learn Mem 12:606-14. 2005
    ..These results suggest that the mPFC participates in both acquisition of a CR and the early stage of consolidation of memory in trace, but not delay eyeblink conditioning by NMDA receptor-mediated operations...
  25. ncbi GABA and its agonists improved visual cortical function in senescent monkeys
    Audie G Leventhal
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Science 300:812-5. 2003
    ..Many treated cells in area V1 of old animals displayed responses typical of young cells. The present results have important implications for the treatment of the sensory, motor, and cognitive declines that accompany old age...
  26. ncbi Contribution of GABA receptors to extinction of memory traces in normal conditions and in a depression-like state
    N I Dubrovina
    State Science Research Institute of Physiology, Siberian Branch, Russian Academy of Medical Sciences, 4 Timakov Street, 630117, Novosibirsk, Russia
    Neurosci Behav Physiol 38:775-9. 2008
    ..Blockade of GABA(B) receptors with faclofen promoted retention of the expression of fear in intact mice and acceleration of extinction in "depressed" mice...
  27. ncbi Contribution of GABAergic cortical circuitry in shaping somatosensory evoked scalp responses: specific changes after single-dose administration of tiagabine
    D Restuccia
    Department of Neurology, Catholic University, Policlinico A Gemelli, L go A 00168 Rome, Italy
    Clin Neurophysiol 113:656-71. 2002
    ..To determine whether conventional as well as high-frequency somatosensory evoked potentials (SEPs) to upper limb stimulation are influenced by GABAergic intracortical circuitry...
  28. ncbi Enhancement of conditioned fear extinction by infusion of the GABA(A) agonist muscimol into the rat prefrontal cortex and amygdala
    Irit Akirav
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Eur J Neurosci 23:758-64. 2006
    ..The involvement of GABA(A) receptors in fear extinction in the prefrontal cortex and amygdala is of particular interest, because of the role of these areas in emotional processes, and the role of the GABA(A) receptors in anxiety states...
  29. ncbi Stress-induced hyperthermia and infection-induced fever: two of a kind?
    Christiaan H Vinkers
    Dept of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences UIPS and Rudolf Magnus Institute of Neuroscience, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Physiol Behav 98:37-43. 2009
    ..Altogether, our findings support the hypothesis that stress-induced hyperthermia and infection-induced fever are two distinct processes mediated largely by different neurobiological mechanisms...
  30. ncbi Effect of cerebellar reversible inactivations on the acquisition of trace conditioned eyeblink responses in guinea pigs: comparison of short and long trace intervals
    Bo Hu
    Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    Neurosci Lett 459:41-5. 2009
    ..These results suggested that while the ipsilateral cerebellum is essential for the expression of trace CRs, its contribution to the acquisition of trace CRs appears to mainly depend on the time length of TI...
  31. ncbi Slow desensitization regulates the availability of synaptic GABA(A) receptors
    L S Overstreet
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Neurosci 20:7914-21. 2000
    ..Accumulation of channels in this absorbing state allows GABA(A) receptors to detect even a few molecules of GABA in the synaptic cleft...
  32. ncbi Effects of rat ventral and dorsal hippocampus temporal inactivation on delayed alternation task
    K Maruki
    Department of Neuropsychiatry, Saitama Medical School, Saitama 350 0495, Japan
    Brain Res 895:273-6. 2001
    ..Ventral hippocampal inactivation showed no changes in the correct ratio, however, it increased the tendency of perseveration in long delay. These findings suggest hippocampus has regional differentiation in delayed alternation task...
  33. ncbi Effects of GABA agonists and GABA-A receptor modulators on cocaine discrimination in rhesus monkeys
    S S Negus
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 152:398-407. 2000
    Dopaminergic systems thought to mediate the abuse-related effects of cocaine are under inhibitory control by GABAergic systems. These findings suggest that GABA agonists may attenuate some abuse-related effects of cocaine.
  34. ncbi Next-day residual effects of gaboxadol and flurazepam administered at bedtime: a randomized double-blind study in healthy elderly subjects
    Julia Boyle
    Human Psychopharmacology Research Unit, University of Surrey, Guildford, Surrey, UK
    Hum Psychopharmacol 24:61-71. 2009
    ..To evaluate the next-day residual effects of the novel hypnotic, gaboxadol, following bedtime dosing in healthy elderly subjects...
  35. ncbi L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors
    John R Atack
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Neuropharmacology 51:1023-9. 2006
    ..These data further support the potential of alpha5-containing GABA(A) receptors as a target for novel cognition enhancing drugs...
  36. ncbi Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human gamma-aminobutyric acid type A receptors
    B Ebert
    Department of Pharmacology, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, England
    Mol Pharmacol 52:1150-6. 1997
    ..It is concluded that the GABAA receptor mechanisms transducing binding into physiological response, but not the binding per se, is dependent on the receptor subunit composition...
  37. ncbi Anticipatory activity in primary motor cortex codes memorized movement sequences
    Xiaofeng Lu
    Brain Sciences Center, Veterans Administration Medical Center, Minneapolis, Minnesota 55417, USA
    Neuron 45:967-73. 2005
    ..Our results challenge the role of medial motor areas in the control of well-practiced movement sequences and suggest that motor cortex contains a complete apparatus for the planning and production of this complex behavior...
  38. pmc Agonist pharmacology of two Drosophila GABA receptor splice variants
    A M Hosie
    Department of Zoology, University of Cambridge
    Br J Pharmacol 119:1577-85. 1996
    ..The differences in the potency of agonists on RDLac and DRC 17-1-2 homo-oligomers observed in the present study may assist in identification of further molecular determinants of GABA receptor function...
  39. ncbi Role for ventral pallidal GABAergic mechanisms in the regulation of ethanol self-administration
    Heidi Kemppainen
    Department of Alcohol, Drugs and Addiction, National Institute for Health and Welfare, POB 30, 00271 Helsinki, Finland
    Psychopharmacology (Berl) 223:211-21. 2012
    ..The medium spiny neurons are GABAergic, but they colocalize enkephalin...
  40. ncbi Effect of repeated gaboxadol administration on night sleep and next-day performance in healthy elderly subjects
    Stefan Mathias
    Section of Sleep Pharmacology, Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 30:833-41. 2005
    ..Gaboxadol persistently improved subjective and objective sleep quality and was devoid of residual effects. Thus, at the employed dose, it seems an effective hypnotic in elderly subjects...
  41. ncbi Dynamism of GABA(A) receptor activation shapes the "personality" of inhibitory synapses
    Jerzy W Mozrzymas
    Department of Biophysics, Wrocław Medical University, ul Chałubińskiego 10, 50 368 Wroclaw, Poland
    Neuropharmacology 47:945-60. 2004
    ..It is proposed that dynamic conditions of synaptic receptor activation assure a broad spectrum of performance rendering the synapse extremely susceptible to a variety of modulatory processes...
  42. ncbi Reevaluating the role of the medial prefrontal cortex in delay eyeblink conditioning
    Guang Yan Wu
    Department of Physiology, College of Basic Medical Sciences, Third Military Medical University, Chongqing 400038, PR China
    Neurobiol Learn Mem 97:277-88. 2012
    ..These results demonstrate that the mPFC is essential for the DEC with the soft tone CS but not for the DEC with the loud tone CS...
  43. ncbi Functional characterization of Musca glutamate- and GABA-gated chloride channels expressed independently and coexpressed in Xenopus oocytes
    Y Eguchi
    Department of Applied Biological Chemistry, Faculty of Agriculture, Kinki University, Nara, Japan
    Insect Mol Biol 15:773-83. 2006
    ..These results suggest that MdGluCl-alpha assists in the expression of MdRdl when the two are coexpressed...
  44. ncbi mGluR antagonists and GABA agonists as novel pharmacological agents for the treatment of autism spectrum disorders
    Lindsay M Oberman
    Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, KS 158, Boston, MA 02215, USA
    Expert Opin Investig Drugs 21:1819-25. 2012
    ..Pharmacological agents that modulate excitation and inhibition are currently in clinical trials for treatment of ASD and show promising preliminary results...
  45. pmc Endogenous GABA and glutamate finely tune the bursting of olfactory bulb external tufted cells
    Abdallah Hayar
    Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurophysiol 98:1052-6. 2007
    ..We suggest that ET cell excitatory and inhibitory inputs may be encoded as a change in the pattern of spike bursting in ET cells, which together with mitral/tufted cells constitute the output circuit of the olfactory bulb...
  46. ncbi Attenuation of morphine withdrawal signs by the GABA(B) receptor agonist baclofen
    S Bexis
    Department of Anaesthesia and Intensive Care, The University of Adelaide, South Australia, Australia
    Life Sci 70:395-401. 2001
    ..It can be concluded that baclofen has some potential in the treatment of opioid withdrawal and that GABA(B) receptors may be implicated in such a withdrawal...
  47. ncbi The distribution of gamma-hydroxybutyrate-induced Fos expression in rat brain: comparison with baclofen
    P S van Nieuwenhuijzen
    School of Psychology, Griffith Taylor Building A19, University of Sydney, Sydney, NSW 2006, Australia
    Neuroscience 158:441-55. 2009
    ..This confirms a unique neuropharmacological profile for GHB and indicates key neural substrates that may underlie its characteristic influence on sleep, body temperature, sociability and endocrine function...
  48. ncbi Electrophysiological assessment of the effect of intrathecal baclofen in spastic children
    B Dachy
    Department of Neurology, CHU Brugmann ULB, Place Van Gehuchten, 4, B 1020, Brussels, Belgium
    Clin Neurophysiol 113:336-40. 2002
    ..To evaluate the effect of intrathecal baclofen in a group of spastic children using electrophysiological procedures described in adults...
  49. pmc Evidence for motivational effects elicited by activation of GABA-A or dopamine receptors in the nucleus accumbens shell
    David Wirtshafter
    Laboratory of Integrative Neuroscience, Department of Psychology M C 285, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607 7137, USA
    Pharmacol Biochem Behav 96:342-6. 2010
    ..Breaking points were also increased by injections of amphetamine into the AcbSh...
  50. ncbi Pharmacotherapy of spasticity: oral medications and intrathecal baclofen
    L E Krach
    Gillette Children s Specialty Healthcare, St Paul, MN 55101, USA
    J Child Neurol 16:31-6. 2001
    ..This article is a review of the sites of action, side effects, and efficacy of benzodiazepines, baclofen, dantrolene sodium, alpha2-adrenergic agonists, and gabapentin. A brief review of intrathecal baclofen is included as well...
  51. ncbi Activation of feeding-related neural circuitry after unilateral injections of muscimol into the nucleus accumbens shell
    Thomas R Stratford
    Laboratory of Integrative Neuroscience, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607 7137, USA
    Brain Res 1048:241-50. 2005
    ....
  52. pmc Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors
    Martin Mortensen
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 588:1251-68. 2010
    ....
  53. ncbi Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain
    T Philip Malan
    Department of Anesthesiology, The University of Arizona, Tucson, Arizona 85724 5114, USA
    Anesthesiology 96:1161-7. 2002
    ..This study tests the hypothesis that loss of spinal activity of gamma-aminobutyric acid (GABA) contributes to the allodynia and hyperalgesia observed after peripheral nerve injury...
  54. ncbi GABA transporters as drug targets for modulation of GABAergic activity
    Arne Schousboe
    Department of Pharmacology, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Biochem Pharmacol 68:1557-63. 2004
    ..A summary of these and other issues are discussed in this brief review...
  55. ncbi Baclofen prevents drug-induced reinstatement of extinguished nicotine-seeking behaviour and nicotine place preference in rodents
    Liana Fattore
    Institute of Neuroscience, Section of Cagliari, National Research Council CNR, c o Department of Neuroscience, University of Cagliari, Cittadella Universitaria of Monserrato, Italy
    Eur Neuropsychopharmacol 19:487-98. 2009
    ..3 mg/kg) CPP in mice. Altogether, our results showed that baclofen is able to antagonise reinstatement of nicotine-seeking and CPP triggered by nicotine primings, suggesting its potential clinical utility as an anti-relapse agent...
  56. ncbi Increases in food intake or food-seeking behavior induced by GABAergic, opioid, or dopaminergic stimulation of the nucleus accumbens: is it hunger?
    Erin C Hanlon
    Neuroscience Training Program, University of Wisconsin Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Psychopharmacology (Berl) 172:241-7. 2004
    ..However, it is not known whether such stimulation mimics a motivational state of food deprivation that commonly enables animals to learn a new operant response to obtain food...
  57. pmc A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons
    Collin J Lobb
    Neurosciences Institute, University of Texas at San Antonio, San Antonio, Texas 78249, USA
    J Neurophysiol 104:403-13. 2010
    ..These results support a bidirectional mechanism by which GABAergic inputs, in balance with NMDA receptor-mediated excitatory inputs, control the firing pattern of dopaminergic neurons...
  58. pmc Post-training reversible inactivation of the hippocampus enhances novel object recognition memory
    Ana M M Oliveira
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Learn Mem 17:155-60. 2010
    ....
  59. ncbi Differential effects of cerebellar, amygdalar, and hippocampal lesions on classical eyeblink conditioning in rats
    Taekwan Lee
    Department of Psychology, Yale University, New Haven, Connecticut 06520 8205, USA
    J Neurosci 24:3242-50. 2004
    ....
  60. ncbi Fear and feeding in the nucleus accumbens shell: rostrocaudal segregation of GABA-elicited defensive behavior versus eating behavior
    S M Reynolds
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 21:3261-70. 2001
    ....
  61. ncbi The GABAB agonist baclofen modifies cocaine self-administration in rats
    M Shoaib
    Preclinical Pharmacology Laboratory, National Institute on Drug Abuse, NIH, Baltimore, Maryland, USA
    Behav Pharmacol 9:195-206. 1998
    ..tested repeatedly for 5 days decreased the number of cocaine injections self-administered. The present findings demonstrate that modulation of GABA systems may have therapeutic potential for the treatment of psychomotor stimulant abuse...
  62. ncbi Evidence of a functional relationship between the nucleus accumbens shell and lateral hypothalamus subserving the control of feeding behavior
    T R Stratford
    Department of Psychiatry, University of Wisconsin Madison Medical School, Madison, Wisconsin 53719, USA
    J Neurosci 19:11040-8. 1999
    Inhibition of neurons in the nucleus accumbens shell (AcbSh) with local injections of GABA agonists or glutamate antagonists elicits an intense, but specific, feeding response resembling that seen after stimulation of the lateral ..
  63. ncbi Sex differences in amino acid release from rostral trigeminal subnucleus caudalis after acute injury to the TMJ region
    D A Bereiter
    Department of Surgery, Brown Medical School, Rhode Island Hospital, 222 Nursing Arts Bldg, Providence, RI 02903, USA
    Pain 98:89-99. 2002
    ..These results also are consistent with the hypothesis that central neural mechanisms that integrate nociceptive inputs from deep craniofacial tissues are different in males and females...
  64. ncbi Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study
    O Kakinohana
    Anesthesiology Research Laboratory 0818, University of California, San Diego 9500 Gilman Drive, San Diego, CA 92093 0818, USA
    Neuroscience 141:1569-83. 2006
    ..The pharmacology of this effect emphasizes the potent role of GABAergic type B receptors in regulating both the spasticity and rigidity...
  65. pmc Different transmitter transients underlie presynaptic cell type specificity of GABAA,slow and GABAA,fast
    Janos Szabadics
    Department of Anatomy and Neurobiology, University of California, 193 Irvine Hall, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 104:14831-6. 2007
    ..These results reveal a form of GABA(A) receptor mediated communication by a dedicated cell type that produces slow ionotropic responses with properties intermediate between phasic and tonic inhibition...
  66. ncbi Baclofen analgesia: involvement of the GABAergic system
    Graciela N Balerio
    Catedra de Farmacologia, Facultad de Farmacia y Bioquímica Universidad de Buenos Aires, Buenos Aires, Argentina
    Pharmacol Res 46:281-6. 2002
    ..p. administration. The data suggest that the antinociceptive effect of baclofen is GABA(B) receptor-mediated and reveal a central location of the analgesic effect of baclofen...
  67. ncbi The effects of ventral tegmental administration of GABA(A), GABA(B), NMDA and AMPA receptor agonists on ventral pallidum self-stimulation
    George Panagis
    University of Crete, School of Social Sciences, Department of Psychology, Crete, Rethymnon, Greece
    Behav Brain Res 131:115-23. 2002
    ..The decreased rewarding efficacy of VP self-stimulation following intrategmental injections of muscimol and baclofen may be due to GABAergic modulation of ventral tegmental dopaminergic and nondopaminergic neurons projecting to the VP...
  68. pmc Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors
    N Brown
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Br J Pharmacol 136:965-74. 2002
    ..With its restricted distribution within the brain and unique pharmacology this receptor may play an important role in the action of neurosteroids and anaesthetics. British Journal of Pharmacology (2002) 136, 965-974..
  69. ncbi An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons
    Fan Jia
    CV Starr Laboratory for Molecular Neuropharmacology, Department of Anesthesiology, Weill Medical College, Cornell University, New York, NY 10021, USA
    J Neurophysiol 94:4491-501. 2005
    ..In view of the critical role of thalamic neurons in the generation of oscillatory activity associated with sleep, these receptors may represent a principal site of action for the novel hypnotic agent gaboxadol...
  70. ncbi Alternative splicing of a Drosophila GABA receptor subunit gene identifies determinants of agonist potency
    A M Hosie
    Babraham Institute, Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, Cambridge, UK
    Neuroscience 102:709-14. 2001
    ....
  71. ncbi Rapid suppression of alcohol withdrawal syndrome by baclofen
    Giovanni Addolorato
    Institute of Internal Medicine, Universita Cattolica del Sacro Cuore, Rome, Italy
    Am J Med 112:226-9. 2002
  72. pmc Effect of GABA agonists and GABA-A receptor modulators on cocaine- and food-maintained responding and cocaine discrimination in rats
    Andrew C Barrett
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    J Pharmacol Exp Ther 315:858-71. 2005
    ..2 mg/kg/injection) or liquid food (0-100%) under a fixed ratio 5 schedule. Six GABA agonists were tested: the GABA-A receptor agonist muscimol, the GABA-B receptor agonist baclofen, the GABA transaminase ..
  73. pmc Effects of GABA agonists on body temperature regulation in GABA(B(1))-/- mice
    Christophe Queva
    Transgenic Research Laboratory, AstraZeneca R and D Molndal, S 431 83 Molndal, Sweden
    Br J Pharmacol 140:315-22. 2003
    ..Using this model, GHB was shown to be a selective GABAB receptor agonist. In addition, GABAB(1)-/- mice are hypersensitive to GABAA receptor stimulation, indicating that GABAB tone normally balances GABAA-mediated effects...
  74. ncbi GABA(B) receptor-mediated modulation of the firing pattern of ventral tegmental area dopamine neurons in vivo
    Sophie Erhardt
    Department of Physiology and Pharmacology, Division of Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
    Naunyn Schmiedebergs Arch Pharmacol 365:173-80. 2002
    ..Physiologically, activation of GABA(B) receptors may subserve a dampening function on VTA DA cell excitability which may counterbalance NMDA receptor-mediated excitation...
  75. ncbi GABA(B) receptors as potential therapeutic targets
    Claire Marie Vacher
    Pharmazentrum, University of Basel, Department of Physiology, Klingelbergstr 50 70, CH 4056 Basel, Switzerland
    Curr Drug Targets CNS Neurol Disord 2:248-59. 2003
    ..Here we provide and update on the molecular composition, the physiology and the pharmacology of GABA(B) receptors and discuss to what extent our current knowledge influences ongoing and future drug discovery efforts...
  76. ncbi GABA(A) receptor alpha1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons
    S Vicini
    Department of Physiology and Biophysics, Georgetown University Medical School, Washington, DC 20007, USA
    J Neurosci 21:3009-16. 2001
    ..We propose that an increased alpha1 subunit assembly in postsynaptic receptors of cerebellar inhibitory synapses is responsible for the fast inhibitory synaptic currents that are normally observed during postnatal development...
  77. ncbi 8-Fluoroimidazo[1,2-a]pyridine: synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABA A receptor
    Alexander C Humphries
    The Neuroscience Research Centre, Merck Sharp and Dohme, Terlings Park, Harlow, Essex CM20 2QR, UK
    Bioorg Med Chem Lett 16:1518-22. 2006
    ..Here, the 8-fluoroimidazopyridine ring contained in ligand 3 acts as a bioisosteric replacement for imidazopyrimidine in the GABA(A) receptor modulator 2...
  78. ncbi Baclofen decreases methamphetamine self-administration in rats
    Robert Ranaldi
    Department of Psychology, Queens College, City University of New York, 65 30 Kissena Blvd, Flushing 11367, USA
    Neuroreport 13:1107-10. 2002
    ..These data are consistent with other studies showing impairment of drug reward after pretreatment with baclofen and add further support to the idea that GABA-B agonists may be useful in the treatment of drug addiction...
  79. ncbi GABA-based therapeutic approaches: GABAA receptor subtype functions
    Uwe Rudolph
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland, and Laboratory of Genetic Neuropharmacology, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Curr Opin Pharmacol 6:18-23. 2006
    ..Thus, a new pharmacology based on GABAA receptor subtype-specific actions is emerging...
  80. ncbi Classic benzodiazepines modulate the open-close equilibrium in alpha1beta2gamma2L gamma-aminobutyric acid type A receptors
    Dirk Rüsch
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Anesthesiology 102:783-92. 2005
    ..The authors tested the hypothesis that benzodiazepine site ligands modulate alpha1beta2gamma2L GABAA receptor gating both in the absence of orthosteric agonists and when the orthosteric sites are occupied...
  81. ncbi An autocrine role for pituitary GABA: activation of GABA-B receptors and regulation of growth hormone levels
    Katia Gamel-Didelon
    Anatomisches Institut der Universität München, Munchen, Deutschland
    Neuroendocrinology 76:170-7. 2002
    ..By contrast, blocking GABA-B receptors by an antagonist, phaclofen, decreased GH levels. We conclude that in GH-producing cells, GABA acts as an autocrine factor via GABA-B receptors to control GH levels...
  82. ncbi Excitatory actions of GABA increase BDNF expression via a MAPK-CREB-dependent mechanism--a positive feedback circuit in developing neurons
    Karl Obrietan
    Department of Neuroscience, The Ohio State University, Columbus 43210, USA
    J Neurophysiol 88:1005-15. 2002
    ..Signaling via the MAPK cascade and the transcription factor CREB appear to play a substantial role in this process...
  83. ncbi Desensitization mechanism of GABA receptors revealed by single oocyte binding and receptor function
    Yongchang Chang
    Department of Neurobiology and Physiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0021, USA
    J Neurosci 22:7982-90. 2002
    ..These data provide direct evidence for a cyclical model of receptor desensitization...
  84. ncbi Post-episode depression of GABAergic transmission in spinal neurons of the chick embryo
    N Chub
    Section on Developmental Neurobiology, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurophysiol 85:2166-76. 2001
    ..We conclude that redistribution of intracellular [Cl(-)] during spontaneous episodes is likely to be an important postsynaptic mechanism involved in the post-episode depression of GABAergic transmission in chick embryo spinal neurons...
  85. ncbi Involvement of the dorsolateral prefrontal cortex of monkeys in visuospatial target selection
    Michiyo Iba
    Laboratory of Neurobiology, Hokkaido University Graduate School of Medicine, N15W7, Sapporo 060 8638, Japan
    J Neurophysiol 89:587-99. 2003
    ..Further, this function of the dorsolateral PFC appears to involve both top-down (active) and bottom-up (passive) target-selection/selective attention processes to control interfering information (distractors)...
  86. pmc Anxiogenic properties of an inverse agonist selective for alpha3 subunit-containing GABA A receptors
    John R Atack
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Br J Pharmacol 144:357-66. 2005
    ....
  87. ncbi Rescue of developing spinal motoneurons from programmed cell death by the GABA(A) agonist muscimol acts by blockade of neuromuscular activity and increased intramuscular nerve branching
    Ronald W Oppenheim
    Department of Neurobiology and Anatomy and the Neuroscience Program, Wake Forest University Medical School, Winston Salem, NC 27157, USA
    Mol Cell Neurosci 22:331-43. 2003
    ..Taken together, these data provide further evidence in support of a peripheral site of action of activity blockade in rescuing motoneurons from developmental cell death...
  88. ncbi Molecular targets for the myorelaxant action of diazepam
    F Crestani
    Institute of Pharmacology and Toxicology, , , Switzerland
    Mol Pharmacol 59:442-5. 2001
    ..Thus, the myorelaxant activity of diazepam seems to be mediated primarily by alpha2 GABA(A) receptors and at high concentrations also by alpha3 GABA(A) receptors...
  89. ncbi Antisaccade deficit after inactivation of the principal sulcus in monkeys
    Carine Condy
    Institut National de la Santé et de la Recherche Médicale U679, Universite Pierre and Marie Curie, France
    Cereb Cortex 17:221-9. 2007
    ..Our results are compatible with a partitioning of the principal sulcus into functional subregions, in which a well-delineated area is critically involved in RS suppression...
  90. ncbi GABA agonists fail to protect the retina from ischemia-reperfusion injury
    Sindri Traustason
    Department of Ophthalmology and Physiology, National University Hospital, University of Iceland, Reykjavik, Iceland
    Exp Eye Res 88:361-6. 2009
    ..in the rat retina may be ameliorated by reducing retinal metabolism with either hypothermia or inhibitory GABA agonists. The intraocular pressure of each right eye in rats was raised to 130 mm Hg for 60 min with the left eye ..
  91. pmc Modulation of GABA(A) receptor channel gating by pentobarbital
    J H Steinbach
    Department of Anesthesiology, Washington University in St Louis, St Louis, MO 63110, USA
    J Physiol 537:715-33. 2001
    ..However, the changes in open-time distributions caused by PB appear to be more complex. Possible explanations of the effects of PB on gating by different agonists are considered...
  92. ncbi GABA(B) receptor agonists for the treatment of drug addiction: a review of recent findings
    Michael S Cousins
    Department of Psychiatry, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Drug Alcohol Depend 65:209-20. 2002
    ..This line of research may also improve our understanding of the neurochemical mechanisms underlying the drug dependence process...
  93. ncbi Activity- and target-dependent regulation of large-conductance Ca2+-activated K+ channels in developing chick lumbar motoneurons
    Miguel Martin-Caraballo
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5513, USA
    J Neurosci 22:73-81. 2002
    ..Conversely, tetrodotoxin caused a decrease in K(Ca) expression in cultured E8 LMNs developing for 3 d in the presence of neurotrophic factors that promote neuronal survival in the absence of target tissues...
  94. ncbi The effects of GABA agonists on glutamic acid decarboxylase, GABA-transaminase, activin, salmon gonadotrophin-releasing hormone and tyrosine hydroxylase mRNA in the goldfish (Carassius auratus) neuroendocrine brain
    C J Martyniuk
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
    J Neuroendocrinol 19:390-6. 2007
    ....
  95. ncbi Muscimol diffusion after intracerebral microinjections: a reevaluation based on electrophysiological and autoradiographic quantifications
    Jean Marc Edeline
    Laboratoire de Neurobiologie de l Apprentissage, de la Memoire et de la Communication, UMR CNRS 8620, Universite Paris Sud, 91405 Orsay, France
    Neurobiol Learn Mem 78:100-24. 2002
    ..25 mm). Thus, these data point out that muscimol diffusion after intracerebral microinjection is larger than usually supposed. The relationships between these results and those obtained in behavioral studies are discussed...
  96. pmc Dissociating anxiolytic and sedative effects of GABAAergic drugs using temperature and locomotor responses to acute stress
    Christiaan H Vinkers
    Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Psychopharmacology (Berl) 204:299-311. 2009
    ..The GABA(A) receptor alpha(1) subunit is associated with sedation, whereas the GABA(A) receptor alpha(2) and alpha(3) subunits are involved in anxiolytic effects...
  97. pmc The pre-M1 segment of the alpha1 subunit is a transduction element in the activation of the GABAA receptor
    Angelo Keramidas
    CV Starr Laboratory for Molecular Pharmacology, Department of Anesthesiology, Weill Medical College, Cornell University, A 1040, 1300 York Avenue, New York, NY 10021, USA
    J Physiol 575:11-22. 2006
    ..77 mM GABA in WT and 1.4 mM GABA in the alpha1(K220A)beta2gamma2s channels. The beta-10 strand (pre-M1 segment) emerges, from this and other studies, as a key functional component in the activation of the GABAAR...
  98. ncbi Hippocampal network hyperactivity after selective reduction of tonic inhibition in GABA A receptor alpha5 subunit-deficient mice
    Joseph Glykys
    Interdepartmental PhD Program for Neuroscience and Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    J Neurophysiol 95:2796-807. 2006
    ....
  99. ncbi Muscimol-induced death of GABAergic neurons in rat brain aggregating cell cultures
    P Honegger
    Institute of Physiology, University of Lausanne, Switzerland
    Brain Res Dev Brain Res 105:219-25. 1998
    ....
  100. ncbi Ability of baclofen in reducing alcohol intake and withdrawal severity: I--Preclinical evidence
    G Colombo
    CNR Center for Neuropharmacology, Bernard B Brodie Department of Neuroscience, University of Cagliari, Italy
    Alcohol Clin Exp Res 24:58-66. 2000
    ....
  101. ncbi GABA mediaties the inhibitory effect of lateral amygdaloid nucleus stimulation on the acoustic response of neurons in A I cortex: An in vivo microiontophoretic study
    De Fu He
    Department of Environmental Science and Brain Science Research Center, East China Normal University, Shanghai 200062, China
    Sheng Li Xue Bao 56:374-8. 2004
    ..These results indicate that GABA is the ultimate transmitter which mediates the LA stimulation-induced inhibition of the acoustic response of A-I neurons in rats, possibly via the GABA(A) receptor...

Research Grants63

  1. Adult Neurogenesis: Regulation By Sleep
    DENNIS J MCGINTY; Fiscal Year: 2013
    ..treatment can depend on hippocampal adult neurogenesis, and adult neurogenesis is facilitated by GABA agonists. There is no specific neurological rationale for coincident management of sleep disorders and MDD or other ..
  2. The Role of Amygdala GABAergic Transmission in Fear and Anxiety
    Scott A Heldt; Fiscal Year: 2011
    ..is particularly rich in GABAARs which are known to be involved in the anxiolytic and anxiogenic effects of GABA agonists and antagonists, respectively...
  3. Limbic-Basal Ganglia Circuitry in PTSD
    Ludise Malkova; Fiscal Year: 2013
    ....
  4. The NKCC1 inhibitor bumetanide as a novel therapy in TSC
    Frances E Jensen; Fiscal Year: 2013
    ..Develop new animal models to study epileptogenesis. Area II. Develop new treatment strategies and improve current approaches in order to cure epilepsy C. Improve current treatments and develop new technologies ..
  5. Prevention of Hippocampal Neurodegeneration due to Age and Apnea
    Michael H Chase; Fiscal Year: 2013
    ..In addition, we will explore a therapeutic agent that has the potential to eliminate or reduce the deficits in hippocampal memory and learning that are especially prominent in aged Veterans with OSA. ..
  6. Regulation of synaptic plasticity by eCBs in adult and aged mammalian cortex
    Karen L Montey; Fiscal Year: 2012
    ..Interestingly, application of GABA agonists directly to the aged visual cortex induces an immediate increase in stimulus selectivity, suggesting the ..
  7. Exploring the role of the central amygdala in vocalization
    IAN CHRISTOPHER HALL; Fiscal Year: 2013
    ..b>GABA agonists will be used to mimic input from the CeA in the isolated brain while recording fictive calling from the ..
  8. New Methods for the Expedited Synthesis of C11 and F18 PET Tracers
    Salvatore D Lepore; Fiscal Year: 2013
    ....
  9. Isolating the Extinction Circuit for Cocaine Seeking
    Ryan T Lalumiere; Fiscal Year: 2013
    ..Rats will receive bilateral microinjections of either GABA agonists to inactivate the structure or the AMPA receptor potentiator PEPA to activate the structure...
  10. Interactions between the ventral hippocampus and amygdala during renewal of fear
    CAITLIN ANNE ORSINI; Fiscal Year: 2011
    ..It is our hope that this work will inform effective therapeutic interventions for those individuals who suffer from anxiety and fear pathologies, such as post-traumatic stress disorder. ..
  11. GABA B agonists revisited: Brain, behavioral and genetic effects in smokers
    Teresa R Franklin; Fiscal Year: 2013
    ..This will have a sustained and lasting impact on smoking treatment strategies and will aid in meeting a major goal set by NIDA, which is to "Eradicate Tobacco Abuse and Addiction". ..
  12. GASTRIC ACID SECRETION AND BUFFER CONTENT AFTER EATING
    Mark Feldman; Fiscal Year: 1991
    ..Thus, this research will focus primarily on the role of gastric acid, mucosal defense factors (bicarbonate, prostaglandins) and a campylobacter-like bacterium on acid-peptic diseases...
  13. Synthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic Pain
    James M Cook; Fiscal Year: 2013
    ..An eventual goal is to replace the addictive opioid analgesics with these safer, non addictive ligands for treatment of all types of neuropathic and inflammatory pain, in human populations. ..
  14. Seizure generation and network excitability in Arx related Infantile Spasms
    Eric D Marsh; Fiscal Year: 2013
    ..the DG and CA3 regions of the hippocampus, we will attempt to locally rescue the phenotype by application of GABA agonists directly into CA3 and the DG...
  15. Neuroprotection by Allopregnanolone through Modulation of GABAA Receptors
    MELISSA HERNANDEZ KELLEY; Fiscal Year: 2010
    ....
  16. PHENCYCLIDINE: A BEHAVIORAL AND NEUROCHEMICAL STUDY
    Herbert Meltzer; Fiscal Year: 1980
    ..DA metabolites DOPAC and HVA were also elevated by PCP in haloperidol treated rats. Administration of PCP to rats pretreated with a low dose of haloperiodol accelerated the AMPT-induced depletion of DA...
  17. Amygdala-cortical interactions in taste perception and learning
    Donald B Katz; Fiscal Year: 2013
    ....
  18. Pain Suppression via Area 3a Lesion
    Barry L Whitsel; Fiscal Year: 2013
    ....
  19. DOPAMINE RECEPTOR SUBTYPES & FUNCTION
    Emanuel Meller; Fiscal Year: 1993
    ..g. Parkinson's disease and schizophrenia). Furthermore, the results may lead to fruitful new strategies for treatment of these and related disorders...
  20. Eszopiclone for the Treatment of PTSD
    Mark H Pollack; Fiscal Year: 2013
    ..Addressing these aims will help inform the treatment of PTSD and have important public health significance. ..
  21. BASAL GANGLIA CONTROL OF POSTURE AND MOVEMENT
    Jonathan Mink; Fiscal Year: 1999
    ..Fourth, multijoint reaching will be evaluated with a two-dimensional video-based digital movement analysis system. ..
  22. Opioid-induced Hyperalgesia in Prescription Opioid Abusers: Effects of Pregabalin
    Margaret A Compton; Fiscal Year: 2013
    ..Testing the GPN, the first-known pharmacotherapy to treat OIH in this population, is an important step toward providing adequate pain relief for patients who abuse prescription opioids. ..
  23. REGULATION OF THE GABA RECEPTOR-CHLORIDE ION CHANNEL
    ROCHELLE SCHWARTZ BLOOM; Fiscal Year: 1991
    ..These drugs which act at 3 distinct sites on the GABA receptor complex include GABA agonists, benzodiazepines and barbiturates. Each of these drugs has anticonvulsant activity...
  24. Neurotoxicity of NMDA Receptor Antagonists
    Frank Sharp; Fiscal Year: 2005
    ..determine whether activation of substantia nigral ventral tegmental area and limbic cortex GABA receptors with GABA agonists prevent the injury produced by systemic PCP and MK-801...
  25. Nucleus Accumbens-Mediated Feeding: Output Pathways
    Thomas R Stratford; Fiscal Year: 2010
    ..For example, injections of GABA agonists into the AcbSh result in a large and very specific increase in feeding, a surprising result given that the ..
  26. COCAINE PHARMACOTHERAPIES FOR COMORBID POPULATIONS
    Thomas Kosten; Fiscal Year: 2003
    ..Trials 3 and 4 are "Disulfiram & GABA agonists with LAAM for cocaine" including 60 patients in randomized, placebo controlled 12 week trials of first ..
  27. Intrathecal Delivery of GABAmide to Reduce Spasticity
    Jay Meythaler; Fiscal Year: 2001
    ..Development of a more effective alternative to intrathecally-delivered baclofen would allow for a significant profit and still decrease the cost of this effective treatment system. ..
  28. GABA Agonists as Pharmacotherapies for Cocaine Abuse
    CRAIG RUSH; Fiscal Year: 2003
    ..Preclinical laboratory experiments have demonstrated that GABA agonists attenuate the effects of cocaine under a variety of behavioral arrangements...
  29. GABA AGONIST THERAPY IN TARDIVE DYSKINESIA
    Carol Tamminga; Fiscal Year: 1999
    ..We propose that these studies will help advance our overall goals of understanding-the mechanism of -TD and developing treatments for-the disorder. ..
  30. GLYCINE POTENTIATION OF ANTICONVULSANT DRUGS
    Steven Peterson; Fiscal Year: 1991
    ..Experiments combining the microinjection of GABA agonists and glycine will establish if the glycine activity in the nigra is a result of an interaction with GABA...
  31. NEURAL BASIS OF AUDIO-VOCAL INTEGRATION
    Walter Metzner; Fiscal Year: 1999
    ..and electrophysiologically and then VOC- inhibition neurons will be reversibly inactivated with the GABA agonists Muscimol (GABA-A, R(+)Baclofen (GABA-B), and trans-4-aminocrotonic acid (GABAC), respectively, while the ..
  32. Influence of subthalamic nucleus on striatal dopamine
    Thomas Wichmann; Fiscal Year: 2004
    ..These studies will provide insight into the role of the STN-SNc interaction under normal and parkinsonian conditions and will help to understand the mechanisms of action of neurosurgical treatments aimed at SIN in parkinsonian patients. ..
  33. SLEEP CONTROL BY THERMOSENSITIVE NEURONS
    Dennis McGinty; Fiscal Year: 2004
    ..These studies will provide a new model of interactions of NREM and REM sleep mechanisms and will contribute to the understanding of human diseases including narcolepsy and affective disorder in which NREM-REM coupling is disordered. ..
  34. GENETIC SELECTION FOR BENZODIAZEPINE SENSITIVITY
    EDWARD GALLAHER; Fiscal Year: 1990
    ..been examined for: a) CNS senistivity to DZ; b) DZ absorption and elimination; c) sensitivity to other BZs, GABA agonists, and sedative hypnotics; d) BZ receptor density and affintiy in various brain areas; e) ethanol tolerance and ..
  35. ROLE OF ENTOPEDUNCULAR NUCLEUS IN KINDLED SEIZURES
    David Hosford; Fiscal Year: 1991
    ..Once the full neural network(s) underlying seizure expression is (are) known, better pharmacologic or surgical manipulation of human seizures may be possible...
  36. ALCOHOL AND GABA-ACTIVE NEUROSTEROIDS
    CHRISTINE MELCHIOR; Fiscal Year: 1992
    ..receptor complex (GBC), such as benzodiazepine agonists, antagonists, and inverse agonists, barbiturates, and GABA agonists and antagonists, are known to interact with the behavioral effects resulting from both acute and chronic ..
  37. SUBSTANTIA NIGRA IN MOVEMENT AND MOVEMENT DISORDERS
    Thomas Wichmann; Fiscal Year: 2000
    ..A. 4). With the hypothesis that abnormal discharge in SNr contributes to Parkinsonian motor signs, it is expected that inactivation of SNr will ameliorate the motor disturbances, and that effects of GPi and SNr lesions will be additive. ..
  38. MOLECULAR MECHANISMS OF DRUGS ON GABA POSTSYNAPTIC EVENT
    Maharaj Ticku; Fiscal Year: 1993
    ..A clearer understanding of the GABA-Aergic transmission is a prerequisite to our understanding of normal biology and in the rational development of drugs for disorders involving a dysfunction of GABA-A receptor system...
  39. CYTOKINES AND STEROID ENZYME EXPRESSION IN BRAIN
    Ayalla Barnea; Fiscal Year: 1993
    ..g., anxiety, drowsiness, and motor dysfunction. Moreover, cytokines can act like GABA agonists in that they induce analgesia...
  40. Solid-Phase Approach to the Synthesis of CII PET Tracers
    SALVATORE LEPORE; Fiscal Year: 2005
    ..abstract_text> ..
  41. Glutamate-Mediated Attenuation of Cocaine Craving
    SHELLEY AMEN; Fiscal Year: 2009
    ....
  42. Comorbidity in Cocaine and Opioid Pharmacotherapy
    THOMAS RICHARD KOSTEN; Fiscal Year: 2010
    ..supports Goal 1 with a human laboratory for phase 1 testing of pharmacotherapies that currently include GABA agonists, and by 2006 will include a highly specific dopamine reuptake inhibitor (RTI 336) and a monoclonal antibody...
  43. GABA AND NEUROPATHIC PAIN
    THOMAS MALAN; Fiscal Year: 2000
    ..It tests the related hypothesis that spinally administered GABA agonists will be effective allodynia and hyperalgesia, that GABA agonists given at the time of nerve injury will reduce ..
  44. Hearing loss affects synaptic balance in auditory cortex
    Dan Sanes; Fiscal Year: 2009
    ..Pre- or postsynaptic involvement will be assessed with focal delivery of GABA agonists, and miniature IPSCs...
  45. Frontal Lobe Involvement in Complex Predictive Pursuit
    RONALD KETTNER; Fiscal Year: 2005
    ..each monkey, that part of the FEF most active during pursuit will be deactivated by reversible injections of GABA agonists to study the global role of the FEF during predictive pursuit...
  46. MOLECULAR TARGET FOR STERIOD ANESTHESIA
    NEIL KRIEGER; Fiscal Year: 1991
    ..g. GABA agonists, benzodiazepines) and ion (36Cl-) flux...
  47. Neurochemistry of Nicotine Dependence in Schizophrenia
    Wynne Schiffer; Fiscal Year: 2004
    ..Or increase inhibitory activity with the GABA agonist, gamma-vinyl GABA, prior to the nicotine challenge. We hope to guide the development of novel therapies for dual-diagnosis schizophrenia. ..
  48. MECHANISMS OF SYNAPTIC INHIBITION IN NEOCORTEX
    Johannes van Brederode; Fiscal Year: 2001
    ....
  49. MITOCHONDRIA RELATED EVENTS IN TRAUMATIC BRAIN INJURY
    MALCOLM BULLOCK; Fiscal Year: 2004
    ..damage to inhibitory GABA Cl channels exacerbates neuronal damage, and thus worsens outcomes, and that GABA agonists improve outcome...
  50. RETINAL RHOL GABA CHANNEL ISOFORM
    Jahanshah Amin; Fiscal Year: 2001
    ..3. Pharmacology of the rho 1-in receptor channels with a variety of GABA agonists is distinct from that of the rho 1 receptor channels...
  51. ODOR RESPONSES AND ANATOMY OF OLFACTORY BULB NEURONS
    Kathryn Hamilton; Fiscal Year: 1991
    ..The correlated analysis of odor responses is anticipated to provide new and significant information about the processing of odor information in olfactory bulb circuits...
  52. NMDA Antagonist-induced Neurotoxicity in Schizophrenia
    SEONG SHIM; Fiscal Year: 2003
    ..2) assess electrophysiological impairment induced by the administration of PCP and the preventive action of GABA agonists, and 3) assess changes in glutamate and GABA release induced by the administration of PCP and the preventive ..
  53. Cortical processing of multiple depth cues
    Ying Zhang; Fiscal Year: 2005
    ..In the third phase of the research the role various neurotransmitters play in depth analysis will be assessed by making local injections of glutamate and GABA agonists and antagonists.
  54. BASAL GANGLIA GABA-DOPAMINE INTERACTIONS
    James Bennett; Fiscal Year: 1990
    ..The results of these experiments will allow neurochemical correlates to be drawn to our behavioral observations...
  55. Thalamocortical Abnormalities in Central Pain Syndrome
    Raimi L Quiton; Fiscal Year: 2010
    ..The proposed project will provide novel data that should improve understanding of the pathophysiological mechanisms underlying CPS and aid in the development of more effective treatments for this debilitating disorder. ..
  56. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2010
    ..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
  57. Discriminative Stimulus Effects of Alcohol in Mice
    Wouter Koek; Fiscal Year: 2007
    ..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. [unreadable] [unreadable] [unreadable]..
  58. SEXUAL DIMORPHISM IN SEIZURE CONTROL
    JANA VELISKOVA; Fiscal Year: 2002
    ..Rats of both sexes and various ages will be used. These studies may lead to the development of new antiepileptic treatments that take into the account sexual age-related differences. ..
  59. Prenatal Corticosteroid Impact on Hippocampus
    LIBOR VELISEK; Fiscal Year: 2004
    ..The data of this proposal will be critical for determining long-term adverse effects of multiple course prenatal corticosteroid therapy and for the ameliorating these effects in the offspring. ..
  60. Novel GABA Actions on the Developing Brain
    Joseph Nunez; Fiscal Year: 2008
    ..I intend to pursue this research in a laboratory of my own. ..