gaba agents

Summary

Summary: Substances used for their pharmacological actions on GABAergic systems. GABAergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function.

Top Publications

  1. ncbi GABAergic control of food intake in the meat-type chickens
    H Jonaidi
    Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, 76169 133 Kerman, Iran
    Physiol Behav 76:465-8. 2002
  2. ncbi Tiagabine, a GABA uptake inhibitor, attenuates 3-nitropropionic acid-induced alterations in various behavioral and biochemical parameters in rats
    Ashish Dhir
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Prog Neuropsychopharmacol Biol Psychiatry 32:835-43. 2008
  3. ncbi Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus
    Annalisa Scimemi
    Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 25:10016-24. 2005
  4. ncbi Intravenous sodium valproate aborts migraine headaches rapidly
    R Shahien
    Department of Neurology, Ziv Medical Center, Safed, Israel
    Acta Neurol Scand 123:257-65. 2011
  5. ncbi Comparison of the effect of topiramate and sodium valporate in migraine prevention: a randomized blinded crossover study
    Vahid Shaygannejad
    Department of Neurology, Isfahan University of Medical Sciences and Health Services, Isfahan, Iran
    Headache 46:642-8. 2006
  6. ncbi Valproic acid in prophylaxis of refractory migraine
    A K Erdemoglu
    Kirikkale University, Faculty of Medicine, Department of Neurology, Turkey
    Acta Neurol Scand 102:354-8. 2000
  7. ncbi Effects of intrahippocampal injection of GABAergic drugs on memory retention of passive avoidance learning in rats
    M R Zarrindast
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    J Psychopharmacol 16:313-9. 2002
  8. ncbi GABAergic modulation of the ANG II-induced drinking response in the rat medial preoptic nucleus
    Junichi Tanaka
    Department of Curriculum, Teaching and Memory, Naruto University of Education, Takashima, Naruto cho, Naruto, Tokushima 772 8502, Japan
    Pharmacol Biochem Behav 76:43-51. 2003
  9. ncbi Glycinergic and GABA(A)-mediated inhibition of somatic motoneurons does not mediate rapid eye movement sleep motor atonia
    Patricia L Brooks
    Department of Cell and Systems Biology, Systems Neurobiology Laboratory, University of Toronto, Toronto, Ontario, Canada M5S 3G5
    J Neurosci 28:3535-45. 2008
  10. ncbi Methodological approaches for the study of GABA(A) receptor pharmacology and functional responses
    Alison J Smith
    Neuroscience Research Centre, Terlings Park, Merck, Sharp and Dohme Research Laboratories, Eastwick Rd, CM20 2QR, Harlow, Essex, UK
    Anal Bioanal Chem 377:843-51. 2003

Research Grants

  1. SEXUAL DIMORPHISM IN SEIZURE CONTROL
    JANA VELISKOVA; Fiscal Year: 2002
  2. Altering Sedation Paradigms to Improve Brain Injury and Survival in Severe Sepsis
    Pratik Pandharipande; Fiscal Year: 2013
  3. Early Life Seizures and Development of Gabaergic Inhibition in the Human Brain
    Laura A Jansen; Fiscal Year: 2013
  4. COCAINE PHARMACOTHERAPIES FOR COMORBID POPULATIONS
    Thomas Kosten; Fiscal Year: 2003
  5. STEROID REGULATION OF ION CHANNELS
    Leslie Henderson; Fiscal Year: 1999
  6. CONTROL OF SLEEP AND AROUSAL
    NOOR ALAM; Fiscal Year: 2003
  7. NOVEL COCAINE PHARMACOTHERAPIES: LAB STUDIES
    Margaret Haney; Fiscal Year: 2003
  8. Comorbidity in Cocaine and Opioid Pharmacotherapy
    THOMAS RICHARD KOSTEN; Fiscal Year: 2010
  9. Novel GABA Actions on the Developing Brain
    Joseph Nunez; Fiscal Year: 2008
  10. AMPHETAMINE ENHANCED STROKE RECOVERY--BURKE SRCI GROUP
    Larry Goldstein; Fiscal Year: 2002

Detail Information

Publications227 found, 100 shown here

  1. ncbi GABAergic control of food intake in the meat-type chickens
    H Jonaidi
    Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, 76169 133 Kerman, Iran
    Physiol Behav 76:465-8. 2002
    ..Food intake was not affected by the intracerebroventricular injection of baclofen. These results suggest that GABA acts within the brain of broilers at a GABA(A), but not GABA(B), receptor to increase voluntary food intake...
  2. ncbi Tiagabine, a GABA uptake inhibitor, attenuates 3-nitropropionic acid-induced alterations in various behavioral and biochemical parameters in rats
    Ashish Dhir
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Prog Neuropsychopharmacol Biol Psychiatry 32:835-43. 2008
    ..i.p.) significantly reversed 3-nitropropionic acid-induced alterations in various behavioral and biochemical parameters and it could be a therapeutic agent for the treatment of Huntington's disease...
  3. ncbi Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus
    Annalisa Scimemi
    Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 25:10016-24. 2005
    ..The relative contribution of these components changes after the induction of epilepsy, implying an adaptive plasticity of the tonic current in the presence of spontaneous seizures...
  4. ncbi Intravenous sodium valproate aborts migraine headaches rapidly
    R Shahien
    Department of Neurology, Ziv Medical Center, Safed, Israel
    Acta Neurol Scand 123:257-65. 2011
    ..This preliminary study was designed to evaluate the efficacy and safety of intravenous sodium valproate in managing severe migraine headache...
  5. ncbi Comparison of the effect of topiramate and sodium valporate in migraine prevention: a randomized blinded crossover study
    Vahid Shaygannejad
    Department of Neurology, Isfahan University of Medical Sciences and Health Services, Isfahan, Iran
    Headache 46:642-8. 2006
    ..Topiramate and sodium valporate are anticonvulsants, demonstrated to be effective as monotherapy for migraine prevention in placebo-controlled trials...
  6. ncbi Valproic acid in prophylaxis of refractory migraine
    A K Erdemoglu
    Kirikkale University, Faculty of Medicine, Department of Neurology, Turkey
    Acta Neurol Scand 102:354-8. 2000
    ..The efficacy and safety of valproic acid were assessed as a prophylactic agent in migraine patients who previously derived no significant benefit from conventional prophylactic medications for migraine...
  7. ncbi Effects of intrahippocampal injection of GABAergic drugs on memory retention of passive avoidance learning in rats
    M R Zarrindast
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    J Psychopharmacol 16:313-9. 2002
    ..Atropine decreased memory retention by itself and potentiated the response of muscimol and baclofen. It is concluded that GABAA and GABAB receptor activation may be involved in the impairment of memory retention...
  8. ncbi GABAergic modulation of the ANG II-induced drinking response in the rat medial preoptic nucleus
    Junichi Tanaka
    Department of Curriculum, Teaching and Memory, Naruto University of Education, Takashima, Naruto cho, Naruto, Tokushima 772 8502, Japan
    Pharmacol Biochem Behav 76:43-51. 2003
    ....
  9. ncbi Glycinergic and GABA(A)-mediated inhibition of somatic motoneurons does not mediate rapid eye movement sleep motor atonia
    Patricia L Brooks
    Department of Cell and Systems Biology, Systems Neurobiology Laboratory, University of Toronto, Toronto, Ontario, Canada M5S 3G5
    J Neurosci 28:3535-45. 2008
    ..Our data refute the prevailing hypothesis that REM atonia is caused by glycinergic inhibition. The inhibitory mechanism mediating REM atonia therefore requires reevaluation...
  10. ncbi Methodological approaches for the study of GABA(A) receptor pharmacology and functional responses
    Alison J Smith
    Neuroscience Research Centre, Terlings Park, Merck, Sharp and Dohme Research Laboratories, Eastwick Rd, CM20 2QR, Harlow, Essex, UK
    Anal Bioanal Chem 377:843-51. 2003
    ....
  11. ncbi Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety
    A N Talalaenko
    Department of Pharmacology and Clinical Pharmacology, M Gor kii Medical University, 16 Il ich Prospekt, 83003 Donetsk, Ukraine
    Neurosci Behav Physiol 33:255-61. 2003
    ....
  12. ncbi [Stiff-person syndrome]
    Koichiro Sakai
    Department of Neurology, Kanazawa Medical University
    Nihon Rinsho 60:838-41. 2002
  13. ncbi The role of GABA in anxiety disorders
    R Bruce Lydiard
    Medical University of South Carolina, Charleston, USA
    J Clin Psychiatry 64:21-7. 2003
    ..The article concludes with further support for the role of the GABA system in anxiety by summarizing the current evidence supporting the use of novel GABAergic agents including tiagabine in the treatment of anxiety disorders...
  14. ncbi Interaction of pentobarbital with gabaergic drugs acting on the Cl(-)-ATPase activity of the plasma membranes from bream brain (Abramis brama L.)
    Sergey Menzikov
    Papanin Institute of Biology of Inland Waters, Russian Academy of Sciences, Borok, Yaroslavl Region, 152742 Russia
    Neurosci Lett 334:161-4. 2002
    ....
  15. ncbi On the putative physiological role of allopregnanolone on GABA(A) receptor function
    G Puia
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 W Taylor St MC912, Chicago, IL 60612, USA
    Neuropharmacology 44:49-55. 2003
    ....
  16. ncbi Kavalactones and dihydrokavain modulate GABAergic activity in a rat gastric-brainstem preparation
    Chun Su Yuan
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago 60637, USA
    Planta Med 68:1092-6. 2002
    ..Our results demonstrated modulation of brainstem GABAergic mechanism by kavalactones and dihydrokavain, and suggested that these compounds may play an important role in regulation of GABAergic neurotransmission...
  17. ncbi Brain-derived neurotrophic factor facilitates glutamate and inhibits GABA release from hippocampal synaptosomes through different mechanisms
    Nuno Canas
    Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Av Prof Egas Moniz, Lisbon 1649 028, Portugal
    Brain Res 1016:72-8. 2004
    ..It is concluded that BDNF influences in an opposite way, through distinct mechanisms, the release of glutamate and the release of GABA from hippocampal synaptosomes...
  18. ncbi Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing
    Maryline Marcade
    Department of Neurology, ExonHit Therapeutics, Paris, France
    J Neurochem 106:392-404. 2008
    ..Our findings therefore indicate a relationship between GABA(A) receptor signalling, the alpha-secretase pathway and neuroprotection, documenting a new therapeutic approach for AD treatment...
  19. ncbi GABA and schizophrenia: a review of basic science and clinical studies
    Adel Wassef
    University of Texas Health Sciences Center, Room 2C 07, Houston Harris County Psychiatric Center, 2800 South MacGregor Way, Houston, TX 77021, USA
    J Clin Psychopharmacol 23:601-40. 2003
    ..A converging body of evidence implicates the gamma-aminobutyric acid (GABA) neurotransmitter system in the pathogenesis of schizophrenia...
  20. ncbi Characterisation of the effects of ATPA, a GLU(K5) kainate receptor agonist, on GABAergic synaptic transmission in the CA1 region of rat hippocampal slices
    V R J Clarke
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Neuropharmacology 47:363-72. 2004
    ..However, LY382884 is less potent as an antagonist of the effects of ATPA on IPSPs compared to its depressant effect on EPSPs...
  21. ncbi Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunction
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, W1651 BST, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 174:143-50. 2004
    ....
  22. ncbi GABAA receptors mediate postnatal depression of respiratory frequency by barbiturates
    Ralph F Fregosi
    Department of Physiology, College of Medicine, The University of Arizona, Tucson, AZ 85721, USA
    Respir Physiol Neurobiol 140:219-30. 2004
    ..Stimulation of GABAA receptors slowed respiratory rhythm from the first postnatal day, with no change in efficacy over the first 3 days of life...
  23. ncbi GABAergic integration of progesterone and androgen feedback to gonadotropin-releasing hormone neurons
    Shannon D Sullivan
    Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Biol Reprod 72:33-41. 2005
    ....
  24. ncbi Valproic acid induces manifestations of simultaneous dopamine enhancement and reduction in schizophrenia
    Lina M Lopez
    Neuropsychopharmacology 29:1217; author reply 1218-20. 2004
  25. pmc Relations between substrate affinities and charge equilibration rates in the rat GABA cotransporter GAT1
    Andrea Soragna
    Department of Structural and Functional Biology, University of Insubria, Via Dunant 3, 21100 Varese, Italy
    J Physiol 562:333-45. 2005
    ..Together these observations suggest a kinetic basis for GABA affinity with higher turnover rates resulting in lower affinity, and indicate that an efficient uptake requires a compromise between these two parameters...
  26. ncbi Sequential release of GABA by exocytosis and reversed uptake leads to neuronal swelling in simulated ischemia of hippocampal slices
    Nicola J Allen
    Department of Physiology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 24:3837-49. 2004
    ..These data show that ischemia releases GABA initially by exocytosis and then by reversal of GAT-1 transporters and that the resulting Cl- influx through GABA(A) receptor channels causes potentially neurotoxic cell swelling...
  27. ncbi Epigenetic downregulation of GABAergic function in schizophrenia: potential for pharmacological intervention?
    Erminio Costa
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
    Mol Interv 3:220-9. 2003
  28. ncbi GABAA-benzodiazepine-chloride receptor-targeted therapy for tinnitus control: preliminary report
    Abraham Shulman
    Martha Entenmann Tinnitus Research Center, Health Science Center at Brooklyn, State University of New York, Box 1239, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Int Tinnitus J 8:30-6. 2002
    ..Patients with a predominantly central type tinnitus experience significant tinnitus control with medication directed to the gamma-aminobutyric acid-benzodiazepine-chloride receptor...
  29. ncbi Retrograde GABA signaling adjusts sound localization by balancing excitation and inhibition in the brainstem
    Anna K Magnusson
    Department Biologie II, Division of Neurobiology, LMU Munich, Grosshadernerstrasse 2, 82152 Martinsried, Germany
    Neuron 59:125-37. 2008
    ....
  30. ncbi GABA and histamine interaction in the basolateral amygdala of rats in the plus-maze test of anxiety-like behaviors
    Akbar Hajizadeh Moghaddam
    Department of Biology, Mazandaran University, Babolsar, Iran
    Pharmacology 82:59-66. 2008
    ..In conclusion, it seems that both GABAergic and histaminergic systems not only play a part in the modulation of anxiety-like behaviors in the BLA of rats but may also have opposite effects in this brain region...
  31. ncbi Changes of body temperature and thermoregulatory responses of freely moving rats during GABAergic pharmacological stimulation to the preoptic area and anterior hypothalamus in several ambient temperatures
    Takayuki Ishiwata
    Department of Biology, Graduate School of Science, Tokyo Metropolitan University, 1 1 Minami Ohsawa, Hachioji, Tokyo 192 0397, Japan
    Brain Res 1048:32-40. 2005
    ..It is a neurotransmitter for inhibition of heat production under hot ambient temperature...
  32. ncbi Pharmacology of valproate
    Michael J Owens
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    Psychopharmacol Bull 37:17-24. 2003
    ..Modern tools of basic and clinical neuroscience (eg, genomics, proteomics, functional brain imaging) will rapidly provide valuable insights into the precise mechanism(s) of action of valproate...
  33. ncbi The heterogeneity of central benzodiazepine receptor subtypes in the human hippocampal formation, frontal cortex and cerebellum using [3H]flumazenil and zolpidem
    Mark McLeod
    The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute, Locked Bag 11, Parkville, Victoria 3052, Australia
    Brain Res Mol Brain Res 104:203-9. 2002
    ..Moreover, our data suggests that the differential distribution of the zolpidem insensitive component of [3H]flumazenil binding is an indicator of GABA/BZ receptors assembled by different subunits within the human brain...
  34. ncbi GABA(A) receptor ligands and their therapeutic potentials
    Bente Frølund
    Departments of Medicinal Chemistry, The Royal Danish School of Pharmacy, Copenhagen, DK 2100, Denmark
    Curr Top Med Chem 2:817-32. 2002
    ....
  35. pmc GABA B receptor is a novel drug target for pancreatic cancer
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA
    Cancer 112:767-78. 2008
    ..The aim of the study was to investigate if GABA B R inhibits beta-AR signaling in PDAC and pancreatic duct epithelial cells, thus blocking driving forces of cancer progression, such as cell proliferation and cell migration...
  36. ncbi Uptake and release of [(3)H]GABA in human dental pulp
    Khashayar Nassery
    School of Dentistry, The University of Adelaide University, Adelaide, South Australia 5005, Australia
    Arch Oral Biol 52:607-13. 2007
    ..These results imply that GABA can be taken up and bound firmly in compartments within human dental pulp, GABA can be released from isolated pulp segments by electrical stimulation, and this release is modulated by GABA(B) autoreceptors...
  37. ncbi Epigenetic targets in GABAergic neurons to treat schizophrenia
    E Costa
    Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Adv Pharmacol 54:95-117. 2006
  38. pmc Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation
    Ping Li
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Physiol 584:789-800. 2007
    ..The findings suggest that previous studies overestimate the minimum concentration of steroid capable of potentiating GABA actions at GABA-A receptors. The results have implications for the physiological role of endogenous neurosteroids...
  39. ncbi GABAb receptors regulate chick retinal calcium waves
    M Catsicas
    Department of Physiology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 21:897-910. 2001
    ..GABA(B) receptors are likely to be of key importance in regulating retinal development...
  40. pmc Evidence for an extended duration of GABA-mediated excitation in the developing male versus female hippocampus
    Joseph L Nunez
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Dev Neurobiol 67:1879-90. 2007
    ..This converging evidence infers that sex affects the duration of GABA(A) receptor-mediated excitation during normal hippocampal development, and provides a mechanism by which the effect is mediated...
  41. ncbi Gamma-aminobutyric acid (GABA) stimulates pancreatic cancer growth through overexpressing GABAA receptor pi subunit
    Akio Takehara
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Res 67:9704-12. 2007
    ..These findings imply that GABA and GABRP could play important roles in PDAC development and progression, and that this pathway can be a promising molecular target for the development of new therapeutic strategies for PDAC...
  42. ncbi Activation of GABA(A) receptors facilitates astroglial differentiation induced by ciliary neurotrophic factor in neural progenitors isolated from fetal rat brain
    Masanori Yoneyama
    Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kanazawa, Ishikawa, Japan
    J Neurochem 100:1667-79. 2007
    ....
  43. ncbi Various GABA-mimetic drugs differently affect cocaine-evoked hyperlocomotion and sensitization
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna, Poland
    Eur J Pharmacol 541:163-70. 2006
    ..The finding that vigabatrin protected against the development and the expression of cocaine sensitization further supports its therapeutic potential in the treatment of cocaine dependence...
  44. ncbi GABAergic drugs for the treatment of migraine
    Anja Puppe
    Department of Neurology, Cologne City Hospitals, University of Cologne, Germany
    CNS Neurol Disord Drug Targets 6:247-50. 2007
    ..This review summarizes the current knowledge and evidence for GABAergic drugs in the treatment of migraine...
  45. ncbi Effects of GABA-transporter (GAT) inhibitors on rat behaviour in open-field and elevated plus-maze
    U Schmitt
    Department of Psychiatry, University of Mainz, Germany
    Behav Pharmacol 10:131-7. 1999
    ..SKF 89976-A exhibited minimal effects over the dose range tested. These results indicate that inhibition of GABA uptake might be a pharmacological strategy to treat not only epilepsy, but also anxiety disorders...
  46. ncbi Visual field defect during therapy with valproic-acid
    C Tilz
    Department of Neurology 1, Krankenhaus Barmherzige Brüder Linz, Austria
    Eur J Neurol 14:929-32. 2007
    ..In conclusion, the concentric visual field defect related to VPA treatment is rare but possible...
  47. ncbi Cross-talking between 5-HT3 and GABAA receptors in cultured myenteric neurons
    Marcela Miranda-Morales
    Instituto Potosino de Investigacion Cientifica y Tecnologica, San Luis Potosi, Mexico
    Synapse 61:732-40. 2007
    ..Our proposal is that GABA(A) and 5-HT(3) channels are organized in clusters and within these, both channels can cross-inhibit each other, likely by allosteric interactions between these proteins...
  48. pmc Androgens predispose males to GABAA-mediated excitotoxicity in the developing hippocampus
    Joseph L Nunez
    Department of Physiology, University of Maryland, Baltimore, Baltimore, MD 21201, USA
    Exp Neurol 210:699-708. 2008
    ..This novel effect of androgen on GABA-mediated excitotoxicty suggests a unique opportunity for a sex-specific therapeutic approach involving antagonism of the androgen receptor in neonatal males at risk for brain injury...
  49. ncbi Discriminative stimulus effects of tiagabine and related GABAergic drugs in rats
    L M McDonald
    Merck, Sharp and Dohme, Terlings Park, CM21 2QR, Harlow, Essex, UK
    Psychopharmacology (Berl) 197:591-600. 2008
    ..Tiagabine is an anticonvulsant drug which may also have sleep-enhancing properties. It acts by inhibiting reuptake at the gamma-aminobutyric acid (GABA) transporter (GAT-1)...
  50. ncbi Effect of intracerebroventricular injection of GABA receptor agents on morphine-induced antinociception in the formalin test
    Mitra Mahmoudi
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Iran
    J Psychopharmacol 16:85-91. 2002
    ..However, the antinociception induced by GABA receptor agonists may be mediated partly through supraspinal opioid receptor mechanisms and, for the GABA(B) receptor agonist, through spinal and supraspinal opioid receptor mechanisms...
  51. ncbi Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. A computational study on gamma-aminobutyric acid (GABA) related compounds
    Paolo Tosco
    Dipartimento di Scienza e Tecnologia del Farmaco, Universita degli Studi di Torino, Via Pietro Giuria 9, I 10125, Torino, Italy
    J Mol Model 14:279-91. 2008
    ..Figure 4-(omega-aminoalkyl)-1,2,5-oxadiazole-3-ol analogues of GABA...
  52. pmc Peripheral GABAA receptor-mediated effects of sodium valproate on dural plasma protein extravasation to substance P and trigeminal stimulation
    W S Lee
    Massachusetts General Hospital, Stroke and Neurovascular Regulation, Charlestown 02129, USA
    Br J Pharmacol 116:1661-7. 1995
    ..The dosages required are comparable to those used clinically. Agonists and modulators at the GABAA receptor may become useful for the development of selective therapeutic agents for migraine and cluster headache...
  53. ncbi Enhancement of extinction memory consolidation: the role of the noradrenergic and GABAergic systems within the basolateral amygdala
    Daniel J Berlau
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Neurobiol Learn Mem 86:123-32. 2006
    ..The findings also suggest that the BLA influence on extinction is not mediated by an interaction with the dorsal hippocampus...
  54. ncbi Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias
    Jean Bernard Manent
    INMED, INSERM U29, Universite de la Mediterranee, Campus de Luminy, Marseille, France
    Epilepsia 48:684-93. 2007
    ..The purpose of this study was to investigate the consequences of prenatal exposure to (a) different AEDs and (b) maternal seizures on brain maturational processes in rats...
  55. ncbi Role of endogenous sleep-wake and analgesic systems in anesthesia
    Jun Lu
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 508:648-62. 2008
    ....
  56. ncbi Modulation of presynaptic beta3-containing GABAA receptors limits the immobilizing actions of GABAergic anesthetics
    Christian Grasshoff
    Experimental Anesthesiology Section, Department of Anesthesiology and Intensive Care, Eberhard Karls University, Tuebingen, Germany
    Mol Pharmacol 72:780-7. 2007
    ....
  57. ncbi The NMDA receptor complex: a long and winding road to therapeutics
    Paul L Wood
    Northwestern University, Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Evanston, IL 606201, USA
    IDrugs 8:229-35. 2005
    ..A number of glycine uptake inhibitors have been reported and their preclinical profiles support investigation into their utility in treating schizophrenia...
  58. ncbi Transcranial magnetic stimulation: applications for neuropsychopharmacology
    Seppo Kahkonen
    BioMag Laboratory, Engineering Centre, Helsinki University Central Hospital and Cognitive Brain Research Unit, Department of Psychology, University of Helsinki, Helsinki, Finland
    J Psychopharmacol 18:257-61. 2004
    ..Taken together, TMS provides a new insight to the actions of central nervous system drugs at the cortical level...
  59. ncbi Somatotopical effects of local microinjection of GABAergic agents in Deiters nucleus on the posturokinetic responses to cortical stimulation
    O Pompeiano
    Dipartimento di Fisiologia e Biochimica, , Italy
    J Vestib Res 3:391-407. 1993
    ....
  60. ncbi Acute cold exposure and rewarming enhanced spatial memory and activated the MAPK cascades in the rat brain
    Gang Zheng
    Department of Occupational and Environmental Health, School of Public Health, Fourth Military Medical University, 17 Changlexi Road, Xi an 710032, China
    Brain Res 1239:171-80. 2008
    ..However, GABAA receptor may not be involved in the acute cold exposure-induced enhancement of memory...
  61. ncbi Effect of vigabatrin on contractile response to arachidonic acid and prostaglandins in smooth muscle preparations and platelet aggregation in experimental laboratory animals
    M Raza
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh, 11451, Saudi Arabia
    Pharmacol Res 47:477-83. 2003
    ..8mM) significantly (P<0.05) reversed the anti-aggregatory activity of control aortic prostacycline on ADP-induced aggregation. These findings suggested that VGB might inhibit PGI(2) activity through the inhibition of its synthesis...
  62. ncbi TrkB receptor signaling and activity-dependent inhibitory synaptogenesis
    F J Seil
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    Histol Histopathol 18:635-46. 2003
    When mouse organotypic cerebellar cultures were exposed to anti-GABA agents that increased neuronal activity early in development, there was a doubling of the ratio of inhibitory axosomatic synapse profiles to Purkinje cell somatic ..
  63. ncbi Anxiolytic effects of valproate and diazepam in mice are differentially sensitive to picrotoxin antagonism
    A Dalvi
    Ethopharmacology Laboratory, School of Psychology, University of Leeds, Leeds, LS2 9JT, UK
    Pharmacol Biochem Behav 68:23-32. 2001
    ..Further studies will be required to assess the generality of present findings to other mouse strains, species and behavioural paradigms...
  64. ncbi Passive avoidance learning in the day-old chick is modulated by GABAergic agents
    M P Clements
    Biology Department, Open University, Milton Keynes, UK
    Pharmacol Biochem Behav 53:629-34. 1996
    ..These results suggest a role for the GABAergic system in the acquisition and retention of passive avoidance learning in the day-old chick...
  65. ncbi Depressive symptoms in epilepsy: prevalence, impact, aetiology, biological correlates and effect of treatment with antiepileptic drugs
    J Mitchell Miller
    GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Drugs 68:1493-509. 2008
    ....
  66. ncbi [Seizure exacerbation caused by antiepileptic drugs]
    Karl O Nakken
    Epilepsisenteret SSE, Sandvika, Posboks 53, 1306 Baerum postterminal
    Tidsskr Nor Laegeforen 128:2052-5. 2008
    ..In certain types of epilepsy, antiepileptic drugs can exacerbate the disease instead of improving it...
  67. pmc Gabapentin but not vigabatrin is effective in the treatment of acquired nystagmus in multiple sclerosis: How valid is the GABAergic hypothesis?
    F Bandini
    Department of Neurological Sciences and Vision, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
    J Neurol Neurosurg Psychiatry 71:107-10. 2001
    ..Interaction with cerebral glutamate transmission by inhibition of NMDA receptor might be an alternative hypothesis for the therapeutic action of gabapentin...
  68. pmc Ethanol dually modulates GABAergic synaptic transmission onto dopaminergic neurons in ventral tegmental area: role of mu-opioid receptors
    C Xiao
    Department of Anesthesiology, Physiology and Pharmacology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Neuroscience 153:240-8. 2008
    ..This dual modulation of GABAergic transmission by ethanol may be an important mechanism underlying alcohol addiction...
  69. ncbi Effects of GABAergic agonists and antagonists on oscillatory signal propagation in the guinea-pig accessory olfactory bulb slice revealed by optical recording
    T Sugai
    Department of Physiology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Eur J Neurosci 11:2773-82. 1999
    ..However, actions other than GABAB could also be involved in the depression of the oscillation in the external plexiform and mitral cell layers...
  70. ncbi The pharmacology of spontaneously open alpha 1 beta 3 epsilon GABA A receptor-ionophores
    Gábor Maksay
    Department of Molecular Pharmacology, Chemical Research Center, Hungarian Academy of Sciences, P O Box 17, H 1525, Budapest, Hungary
    Neuropharmacology 44:994-1002. 2003
    ..In conclusion, spontaneously active alpha(1)beta(3) epsilon GABA(A) receptors can be potentiated and blocked by GABAergic agents within a broad range of efficacy...
  71. ncbi Orofacial movements in phospholipase C-related catalytically inactive protein-1/2 double knockout mice: Effect of the GABAergic agent diazepam and the D(1) dopamine receptor agonist SKF 83959
    Katsunori Tomiyama
    Advanced Research Institute for the Sciences and Humanities, Nihon University, Tokyo 102, Japan
    Synapse 64:714-20. 2010
    ..PRIP-mediated regulation of GABA(A)ergic receptor mechanisms influences topographically distinct aspects of orofacial movement and interacts with D(1) receptor systems...
  72. ncbi Prolonged exposure to inhalational anesthetic nitrous oxide kills neurons in adult rat brain
    V Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Health System, P O Box 800710, Charlottesville, VA 22908, USA
    Neuroscience 122:609-16. 2003
    ..Duration of NMDA receptor blockade appears to be an important determinant of whether neurons are reversibly injured or are driven to cell death by an NMDA antagonist drug...
  73. ncbi [Therapeutic approaches to cocaine addiction]
    Laurent Karila
    Centre d enseignement, de Recherche et de Traitement des Addictions, Hôpital Universitaire Paul Brousse, AP HP, INSERM U669, Universite Paris XI, 94804 Villejuif Cedex
    Rev Prat 59:830-4. 2009
    ..Partial agonists at the dopamine D2 receptor and anticocaine vaccines are other promising treatment approaches. It is important to clearly differentiate the detoxification treatment and the relapse prevention treatment phases...
  74. ncbi Case series of painful legs and moving toes: clinical and electrophysiologic observations
    Maria V Alvarez
    Department of Neurology, Mayo Clinic, Scottsdale, Arizona 85259, USA
    Mov Disord 23:2062-6. 2008
    ..Movements were partially suppressible and were diminished but still apparent during light sleep. GABAergic agents were most effective in controlling the pain and the movements...
  75. ncbi [GABA-ergic antiepileptic drugs: pharmacological action and spectrum of clinical activity of tiababine]
    E Pita-Calandre
    Instituto de Neurociencias, Universidad de Granada, Espana
    Rev Neurol 28:495-8. 1999
    ..It is synthesized by the action of glutamic decarboxylase on glutamate and preferently metabolized by the action of GABA transaminase; it experiences neuronal and glial uptake mediated by four types of highly selective transporters...
  76. ncbi GABAergic function in Alzheimer's disease: evidence for dysfunction and potential as a therapeutic target for the treatment of behavioural and psychological symptoms of dementia
    Krista L Lanctot
    Department of Psychiatry, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario
    Can J Psychiatry 49:439-53. 2004
    ..We review the clinical use of GABAergic agents in treating persons with AD symptoms. While newer generation GABAergic medications are now available, they have yet to be evaluated among patients with AD...
  77. ncbi Pharmacotherapy for obsessive-compulsive disorder
    E Hollander
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Psychiatr Clin North Am 23:643-56. 2000
    ..Augmentation and monotherapy have been explored with serotonergic enhancers, dopamine and 5-HT antagonists, enhancers of second-messenger systems, and GABAergic agents with varying efficacy...
  78. pmc Propofol facilitates glutamatergic transmission to neurons of the ventrolateral preoptic nucleus
    Ke Y Li
    Department of Anesthesiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, USA
    Anesthesiology 111:1271-8. 2009
    ..The authors explored the possibility that propofol also promotes sedation less directly by facilitating excitatory inputs to the VLPO GABAergic neurons...
  79. ncbi Susceptibility to drug-induced seizures of Fyn tyrosine kinase-deficient mice
    T Miyakawa
    Department of Psychology, Faculty of Letters, University of Tokyo, Japan
    Neuroreport 7:2723-6. 1996
    ..These results provide evidence of abnormal susceptibility to seizures induced by anti-GABAergic agents and agonists for central excitatory amino acids in Fyn-deficient mice...
  80. ncbi Affect recognition deficits in schizophrenia: neural substrates and psychopharmacological implications
    Amy E Pinkham
    University of Pennsylvania Medical Center, Department of Psychiatry, 10th Floor Gates Building, Philadelphia, PA 19104, USA
    Expert Rev Neurother 7:807-16. 2007
    ..Both serotonergic and anxiolytic GABAergic agents that modulate activation of the limbic system offer promising avenues for remediation efforts...
  81. ncbi Anxiolytic-like and antinociceptive effects of 2(S)-neoponcirin in mice
    Julia Cassani
    Departamento de Sistemas Biologicos, Universidad Autónoma Metropolitana Unidad Xochimilco, Mexico D F C P 04960, Mexico
    Molecules 18:7584-99. 2013
    ..This study investigated the anxiolytic-like, sedative and antinociceptive effects of NEO in several mice models...
  82. ncbi Differential localization and function of GABA transporters, GAT-1 and GAT-3, in the rat globus pallidus
    Xiao Tao Jin
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Eur J Neurosci 33:1504-18. 2011
    ..In conclusion, these data indicate that GAT-1 and GAT-3 represent different target sites through which GABA reuptake may subserve complementary regulation of GABAergic transmission in the rat GP...
  83. ncbi [Current pharmacotherapies and immunotherapy in cocaine addiction]
    Laurent Karila
    Universite Paris Sud, F 94276 Le Kremlin Bicetre, France
    Presse Med 37:689-98. 2008
    ..However, this must be confirmed in larger patient populations...
  84. ncbi New directions in reducing stress effects on cancer
    Amal Melhem-Bertrandt
    Department of Breast Medical Oncology, MD Anderson CancerCenter, Houston, USA
    Cancer Prev Res (Phila) 5:147-9. 2012
    ....
  85. ncbi NMDA receptor activation enhances inhibitory GABAergic transmission onto hippocampal pyramidal neurons via presynaptic and postsynaptic mechanisms
    Jiu Gang Xue
    Department of Neurophysiology, Kagawa School of Pharmaceutical Sciences and Institute of Neuroscience, Tokushima Bunri University, Kagawa, Japan
    J Neurophysiol 105:2897-906. 2011
    ..Thus NMDARs at glutamatergic synapses on both CA1 pyramidal neurons and interneurons appear to exert feedback and feedforward inhibition for determining the spike timing of the hippocampal microcircuit...
  86. ncbi Treatment of tinnitus with acamprosate
    Andréia Aparecida de Azevedo
    OTOSUL, Otorrinolaringologia Sul Fluminense, Volta Redonda, Vila Santa Cecília, Rio de Janeiro, Brazil
    Prog Brain Res 166:273-7. 2007
    ..The drug may improve tinnitus by a dual mechanism of action, acting both as a glutamate antagonist and as a GABA agonist. It is suggested that its action may be both on the ear and the nervous system...
  87. ncbi Spinal 5-HT receptors that contribute to the pain-relieving effects of spinal cord stimulation in a rat model of neuropathy
    Zhiyang Song
    Department of Clinical Neuroscience, Section of Neurosurgery, Karolinska Institutet, Stockholm, Sweden
    Pain 152:1666-73. 2011
    ..The activation of 5-HT(3) receptors appears to operate via spinal GABAergic interneurons...
  88. ncbi Differential functional rescue of Lys(513) and Lys(516) processing mutants of MRP1 (ABCC1) by chemical chaperones reveals different domain-domain interactions of the transporter
    Surtaj H Iram
    Division of Cancer Biology and Genetics, Queen s University, Kingston, ON K7L 3N6, Canada Department of Pathology and Molecular Medicine, Queen s University, Kingston, ON K7L 3N6, Canada
    Biochim Biophys Acta 1838:756-65. 2014
    ..Thus, despite their close proximity to one another in CL5, Lys(513) and Lys(516) participate in different interdomain interactions crucial for the proper folding and assembly of MRP1. ..
  89. ncbi Locust primary neuronal culture for the study of synaptic transmission
    Stefan Weigel
    Peter Grünberg Institute, Institute of Complex Systems, Bioelectronics, Forschungszentrum Julich, 52425, Julich, Germany
    J Mol Histol 43:405-19. 2012
    ..With the demonstration of synapse formation in cell culture of adult locust neurons, this study provides the basis for the future analysis of more defined insect neuronal circuits in culture...
  90. pmc GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites
    Cecilia M Borghese
    Cellular and Molecular Biology, Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA
    J Neurochem 128:363-75. 2014
    ..We conclude that the structure of the alcohol binding site changes during activation and that potentiation or inhibition by binding at inter- or intra-subunit sites is determined by the specific receptor and ligand...
  91. ncbi Subclinical rhythmic electrographic discharges of adults in a patient with migraine
    Evren Burakgazi
    Department of Neurology Camden, UMDNJ, Robert Wood Johnson Medical School, Cooper University Medical Center, NJ, USA
    Clin EEG Neurosci 43:165-8. 2012
    ..These patterns are generally considered nonspecific. We evaluated a 45-year-old female patient with migraine in whom SREDA seemed to have a temporal relation to the migraine symptoms of the patient...
  92. pmc Propofol stimulates noradrenalin-inhibited neurons in the ventrolateral preoptic nucleus by reducing GABAergic inhibition
    Yu Wei Liu
    Department of Anaesthesiology, UMDNJ, New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
    Anesth Analg 117:358-63. 2013
    ..However, how propofol activates VLPO neurons remains unclear. We explored the possibility that propofol activates NA(-) neurons indirectly, by inhibiting GABAergic transmission including those from VLPO NA(+) neurons...
  93. ncbi Design, synthesis and pharmacological evaluation of alpha-substituted N-benzylamides of gamma-hydroxybutyric acid with potential GABA-ergic activity. Part 6. Search for new anticonvulsant compounds
    Barbara Malawska
    Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, 30 688 Krakow, Poland
    Acta Pol Pharm 64:127-37. 2007
    ..Molecular modeling studies have revealed that anticonvulsant activity of the alpha-substituted amides of GHB might partially be explained by the orientation of the terminal benzylamide fragment...
  94. pmc Cellular dynamics of cholinergically induced alpha (8-13 Hz) rhythms in sensory thalamic nuclei in vitro
    Magor L Lorincz
    School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
    J Neurosci 28:660-71. 2008
    ....
  95. ncbi Amyloid-β induces caspase-dependent loss of PSD-95 and synaptophysin through NMDA receptors
    Jinping Liu
    Department of Anatomy, Capital Medical University, Beijing, China
    J Alzheimers Dis 22:541-56. 2010
    ..The identified novel mechanism through which Aβ initiates synaptic dysfunction suggests that selective enhancement of NR2A activity and/or reduction of NR2B activity can halt the manifestation of a key early-stage event in AD...
  96. ncbi Preclinical evidence of new opioid modulators for the treatment of addiction
    Marta Rodriguez-Arias
    Facultad de Psicologia, Departamento de Psicobiologia, Unidad de Investigación Psicobiología de las Drogodependencias, Universitat de Valencia, Avda Blasco Ibáñez 21, Valencia, Spain
    Expert Opin Investig Drugs 19:977-94. 2010
    ..AREA COVERED BY THIS REVIEW: Recent preclinical studies of pharmacological agents for the treatment of opiate addiction (2008 to the present date)...
  97. ncbi Chronic cannabinoid administration in vivo compromises extinction of fear memory
    Hui Ching Lin
    Institute of Basic Medical Sciences and Department of Pharmacology, Center for Gene Regulation and Signal Transduction Research, National Cheng Kung University, Tainan, Taiwan
    Learn Mem 15:876-84. 2008
    ..These results suggest that endocannabinoids within the mPFC play an important role in the extinction of conditioned fear. However, long-term marijuana use may limit its clinical efficacy for the treatment of anxiety disorders...
  98. ncbi Role of the caudal pressor area in the regulation of sympathetic vasomotor tone
    R R Campos
    Departamento de Fisiologia, Disciplina de Fisiologia Cardiovascular e Respiratória, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    Braz J Med Biol Res 41:557-62. 2008
    ..In this brief review, we will address the importance of the ventrolateral medulla neurons for the generation of resting sympathetic tone related to arterial blood pressure control focusing on two regions, the RVLM and the CPA...
  99. ncbi GABA-B(1) receptors are coupled to the ERK1/2 MAP kinase pathway in the absence of GABA-B(2) subunits
    Maxime Richer
    Département de biochimie and Groupe de recherche universitaire sur le médicament GRUM, Universite de Montreal, Montreal, Quebec, Canada
    J Mol Neurosci 38:67-79. 2009
    ..Altogether, our observations show that GABA-B(1A) receptors are able to activate the ERK1/2 pathway despite the absence of surface targetting partner GABA-B(2) in both HEK 293 cells and the DI-TNC1 cell line...
  100. ncbi Possible GABAergic mechanism in the protective effect of allopregnenolone against immobilization stress
    Anil Kumar
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Eur J Pharmacol 602:343-7. 2009
    ..0 mg/kg) and potentiated by muscimol (0.05 mg/kg) pretreatments (P<0.05). Present study suggests that allopregnenolone's protective effect could be due its interaction with gamma-amino butyric acid receptor complex...
  101. ncbi Pre-synaptic GABA receptors inhibit glutamate release through GIRK channels in rat cerebral cortex
    Carolina Ladera
    Departamento de Bioquimica, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    J Neurochem 107:1506-17. 2008
    ....

Research Grants62

  1. SEXUAL DIMORPHISM IN SEIZURE CONTROL
    JANA VELISKOVA; Fiscal Year: 2002
    ..Rats of both sexes and various ages will be used. These studies may lead to the development of new antiepileptic treatments that take into the account sexual age-related differences. ..
  2. Altering Sedation Paradigms to Improve Brain Injury and Survival in Severe Sepsis
    Pratik Pandharipande; Fiscal Year: 2013
    ..5 delirium/coma-free days and an absolute difference in mortality of 10% between the two groups. ..
  3. Early Life Seizures and Development of Gabaergic Inhibition in the Human Brain
    Laura A Jansen; Fiscal Year: 2013
    ..Information gained as a result of this study could have direct clinical applications that produce improved medical and neurologic care of infants and neonates. ..
  4. COCAINE PHARMACOTHERAPIES FOR COMORBID POPULATIONS
    Thomas Kosten; Fiscal Year: 2003
    ..60 patients in randomized, placebo controlled 12 week trials of first disulfiram (#3) and then one of the GABA agents tiagabine or baclofen (#4)...
  5. STEROID REGULATION OF ION CHANNELS
    Leslie Henderson; Fiscal Year: 1999
    ....
  6. CONTROL OF SLEEP AND AROUSAL
    NOOR ALAM; Fiscal Year: 2003
    ..These pharmacological manipulations and analytical procedures will help understanding of the adenosinergic and GABAergic mechanisms that shape the discharge patterns of the MBF neurons across the sleep-waking cycle. ..
  7. NOVEL COCAINE PHARMACOTHERAPIES: LAB STUDIES
    Margaret Haney; Fiscal Year: 2003
    ....
  8. Comorbidity in Cocaine and Opioid Pharmacotherapy
    THOMAS RICHARD KOSTEN; Fiscal Year: 2010
    ..Another study relates polymorphisms of GABA receptors and metabolism to treatment response with GABA agents, and a third relates the short/long promoter polymorphism of the serotonin transporter to treatment response ..
  9. Novel GABA Actions on the Developing Brain
    Joseph Nunez; Fiscal Year: 2008
    ..I intend to pursue this research in a laboratory of my own. ..
  10. AMPHETAMINE ENHANCED STROKE RECOVERY--BURKE SRCI GROUP
    Larry Goldstein; Fiscal Year: 2002
    ..However the treatment duration will be increased to a total of 10 sessions. ..
  11. MIDCAREER INVESTIGATOR AWARD IN CEREBROVASCULAR RESEARCH
    Larry Goldstein; Fiscal Year: 2004
    ....
  12. Marijuana Dependence & Depression: Venlafaxine Treatment
    Frances Levin; Fiscal Year: 2006
    ..3. To examine the relationship between medication treatment, mood improvement, cognitive functioning and improvement in marijuana abuse using mediational analyses. ..
  13. Central Mechanisms of Opiate Reinforcement and Dependence
    George Koob; Fiscal Year: 2008
    ....
  14. FLUOXETINE IN PEDIATRIC BODY DYSMORPHIC DISORDER
    Eric Hollander; Fiscal Year: 2008
    ..Abstract Not Provided. ..
  15. PREDOCTORAL TRAINING PROGRAM IN NEUROSCIENCE
    RALPH FREGOSI; Fiscal Year: 2008
    ..Facilities for research training include the extensive equipment and expertise in individual faculty laboratories, as well as comprehensive shared resources at the University of Arizona. ..
  16. Neurodevelopmental Apoptosis
    Nuri Farber; Fiscal Year: 2008
    ..abstract_text> ..
  17. STATISTICAL ANALYSIS OF HIPPOCAMPAL INFORMATION ENCODING
    Emery Brown; Fiscal Year: 2008
    ..More accurate characterizations of neuronal dynamics may also lead to more physiologically-sound approaches to creating machine-brain interfaces and designing neural prosthetic devices. ..
  18. CORTICAL CIRCUITRY AND COGNITION IN SCHIZOPHRENIA
    David Lewis; Fiscal Year: 2007
    ..Our extensive interactions enable us to conduct a translational research program in schizophrenia that effectively transfers information from the clinic to the laboratory and back to the clinic in a truly bidirectional fashion. ..
  19. GABAergic molecular pathology in schizophrenia
    Erminio Costa; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  20. Greater New York Autism Research Center of Excellence
    Joseph Buxbaum; Fiscal Year: 2007
    ..Core B: Clinical Core; Core C: Data Management and Statistics Core; Core D: Information Transfer Core. ..
  21. Preclin. model for prevention of NSCLC in former smokers
    HILDEGARD SCHULLER; Fiscal Year: 2006
    ....
  22. Emory Conte Center for the Neuroscience of Mental Disorders
    Becky Kinkead; Fiscal Year: 2008
    ..abstract_text> ..
  23. Mapping Abnormal Neurodevelopment in Schizophrenia
    Deanna Barch; Fiscal Year: 2008
    ..unreadable] ..
  24. Extended Release Mixed Amphetamine Salts for Adult ADHD and Cocaine Dependence
    Frances Rudnick Levin; Fiscal Year: 2010
    ..Here a nearly unique opportunity exists to treat two conditions, ADHD and cocaine dependence, with a single medication, hopefully leading to improved treated outcome in this difficult-to-treat population. ..
  25. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2010
    ..This proposal, by testing the efficacy of carvedilol and investigating the influence of withdrawal severity on carvedilol's efficacy, may result in development of more effective treatments for cocaine addiction. ..
  26. Folate in Schizophrenia
    Donald C Goff; Fiscal Year: 2010
    ..This will be the first adequately-powered study to assess efficacy and identify predictors of response. ..
  27. ALCOHOL, GABA AND HORMONES: PHYSIOLOGY OF SUBUNIT CHANGE
    Sheryl S Smith; Fiscal Year: 2010
    ..The results from these studies may provide insight into potential mechanisms for effects of low dose ethanol at GABAR. ..
  28. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2009
    ..The findings of this study will provide valuable information to develop new pharmacotherapies for smoking cessation. ..
  29. Training in Psychopharmacology and Outcomes Research
    Eric Hollander; Fiscal Year: 2008
    ..of Medicine of Medicine of Medicine of Medicine of Medicine of Medicine format shown below. Role on ..
  30. Dynamic Analyses of Learning in Behavioral Experiments
    Emery Brown; Fiscal Year: 2009
    ....
  31. Mechanism of Dopaminergic Arousal
    Jun Lu; Fiscal Year: 2009
    ....
  32. PSYCHOBIOLOGY OF CORTICOTROPIN-RELEASING FACTOR
    Michael Owens; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. Combined Pharmacotherapies for Cocaine Dependence
    Frances Levin; Fiscal Year: 2008
    ..3. To explore a set of related secondary outcomes (treatment retention, global functioning, and HIV risk behavior) as well as moderators and mediators potentially reflective of mechanism of action. [unreadable] [unreadable] [unreadable]..
  34. GABAergic excitation in human hypothalamic hamartoma
    Jie Wu; Fiscal Year: 2007
    ..Knowledge about excitatory GABAA receptor function of HH neurons will also aid selection of superior strategies for pharmaceutical development to prevent and control human gelastic seizures. [unreadable] [unreadable]..
  35. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  36. Tiagabine for Cocaine Dependence in Methadone Treatment
    GERARDO GONZALEZ HADDAD; Fiscal Year: 2007
    ....
  37. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  38. LPH to VTA Neurotensin: Actions and Cocaine Effects
    DANIEL ZAHM; Fiscal Year: 2004
    ..The data may lead to better, more selective therapeutic approaches to prevention of psychostimulant sensitization, which is thought play a significant role in destructive drug seeking behaviors. ..
  39. Statistical Modeling of Functional MRI Signals
    Emery Brown; Fiscal Year: 2004
    ..abstract_text> ..
  40. Blood Genomics of Anticonvulsant Efficacy in Children
    Tracy Glauser; Fiscal Year: 2004
    ..We will study whole blood total RNA using the new human U133 Affymetrix oligonucleotide microarrays that assess over 39,000 transcripts. ..
  41. CLINICAL PHARMACOLOGY OF CHILDHOOD EPILEPSY
    Tracy Glauser; Fiscal Year: 2003
    ....
  42. Control of Synaptic Glutamate Release
    Steven Mennerick; Fiscal Year: 2004
    ..In addition, we expect our results to elucidate details of the mechanisms of action potential coupling to chemical neurotransmission and a possible mechanism of synaptic plasticity. ..
  43. SCHIZOPHRENIA AND PREFRONTAL CORTICAL CIRCUITRY
    David Lewis; Fiscal Year: 2004
    ....
  44. GABA-A RECEPTOR STRUCTURE AND FUNCTION
    Richard Olsen; Fiscal Year: 2003
    ..Studies on these and related proteins will allow us to take a close look a dynamic and important cellular biology of these important brain neurotransmitter receptors. ..
  45. Electrophysiological Action of GHB in Brain Reward Areas
    Vincenzo Crunelli; Fiscal Year: 2003
    ....
  46. NEUROMUSCULAR CONTROL OF THE PHARYNGEAL AIRWAY
    RALPH FREGOSI; Fiscal Year: 2002
    ..These experiments will lay the foundation for new and improved treatment strategies for persons with obstructive sleep apnea or with other conditions that are caused by malfunction of the tongue motor system. ..
  47. TREATMENT OF ADULT ADHD IN METHADONE PATIENTS
    Frances Levin; Fiscal Year: 2002
    ..Overall, this proposal will provide a better understanding of the relationship between ADHD and substance abuse, better diagnostic evaluation, and improved pharmacologic treatment approaches for this sub-population. ..
  48. NNK, Beta-Adrenergic AA Release and Lung Cancer
    HILDEGARD SCHULLER; Fiscal Year: 2005
    ..2. To determine which products of the AA cascade are formed in untreated cells and in response to NNK, which of these products stimulate DNA synthesis, and what downstream effectors are activated by these products. ..
  49. Marijuana Abusing ADHD Teens: Atomoxetine Treatment
    Frances Levin; Fiscal Year: 2004
    ..4. To examine the relationship between medication treatment, reduction in ADHD symptoms, and improvement in retention and/or progress in treatment using mediational analyses. ..
  50. NEW STRATEGIES FOR NEOCORTICAL EPILEPSY
    Steven Rothman; Fiscal Year: 2007
    ..If Peltier devices can control focal seizures in our models, they will be refined for future experiments to investigate their potential role in mapping and controlling epileptogenic neocortex in man. [unreadable] [unreadable]..
  51. Dynamic Signal Processing Analyses of Neural Plasticity
    Emery Brown; Fiscal Year: 2006
    ..abstract_text> ..
  52. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2006
    ..abstract_text> ..
  53. Form/function of Extended Amygdala/Accumbens Shell:CRF
    DANIEL ZAHM; Fiscal Year: 2005
    ....
  54. In Vitro Mechanisms of Ethanol Induced Neuronal Death.
    Steven Mennerick; Fiscal Year: 2005
    ..The proposed experiments should lead to a better fundamental understanding of the mechanisms by which forebrain neurons are susceptible to ethanol-induced death. ..
  55. Pregnanolone's effects in DBA/2J and C57BL/6J mice
    Erin Shannon; Fiscal Year: 2005
    ....
  56. Comorbid Disorders in Treatment of Opiate Dependence
    GERARDO GONZALEZ HADDAD; Fiscal Year: 2005
    ..This K23 research career award will enable me to start an academic career focusing on research in cocaine and opiate dependence and to develop a bridge between clinical trials and services research. ..
  57. Reelin and GAD67 Downregulation
    Erminio Costa; Fiscal Year: 2005
    ....
  58. Throughput Assay:Allosteric Potentiator of GluR (RMI)
    P Conn; Fiscal Year: 2004
    ..This will provide the characterization needed to allow us to optimize this assay for use in future screens of larger compound libraries. ..
  59. Novel therapeutics for chronic pain
    Paul Wood; Fiscal Year: 2005
    ....
  60. PHYSIOLOGY OF APOPTOTIC NEURONAL INJURY IN VITRO
    Steven Rothman; Fiscal Year: 2001
    ..Most important, they will provide direct evidence for the recruitment of apoptotic pathways in ischemic human brain. ..