excitatory amino acid antagonists

Summary

Summary: Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.

Top Publications

  1. ncbi A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression
    Carlos A Zarate
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, and Department of Health and Human Services, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 63:856-64. 2006
  2. ncbi Glutamate exocytosis from astrocytes controls synaptic strength
    Pascal Jourdain
    Department of Cell Biology and Morphology, University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland
    Nat Neurosci 10:331-9. 2007
  3. ncbi Glia-derived D-serine controls NMDA receptor activity and synaptic memory
    Aude Panatier
    INSERM, U378, Bordeaux, F 33077, France
    Cell 125:775-84. 2006
  4. ncbi NMDA receptor subunits: diversity, development and disease
    S Cull-Candy
    Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK
    Curr Opin Neurobiol 11:327-35. 2001
  5. ncbi Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain
    C Ikonomidou
    Department of Pediatric Neurology, Charite Virchow Clinics, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Science 283:70-4. 1999
  6. pmc Glutamate antagonists limit tumor growth
    W Rzeski
    Department of Pediatric Neurology, Children's Hospital, Charite-Virchow Campus, Humboldt University, Augustenburger Platz 1, D-13353 Berlin, Germany
    Proc Natl Acad Sci U S A 98:6372-7. 2001
  7. ncbi Subunit-specific NMDA receptor trafficking to synapses
    Andres Barria
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Neuron 35:345-53. 2002
  8. ncbi Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors
    Sungho Maeng
    Laboratory of Molecular Pathophysiology and Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Biol Psychiatry 63:349-52. 2008
  9. ncbi Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus
    Thomas E Bartlett
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Neuropharmacology 52:60-70. 2007
  10. ncbi Expression of glutamate receptor subunits in human cancers
    Andrzej Stepulak
    Department of Biochemistry and Molecular Biology, Medical University of Lublin, Lublin 20 093, Poland
    Histochem Cell Biol 132:435-45. 2009

Detail Information

Publications290 found, 100 shown here

  1. ncbi A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression
    Carlos A Zarate
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, and Department of Health and Human Services, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 63:856-64. 2006
    ..Converging lines of evidence suggest the role of the glutamatergic system in the pathophysiology and treatment of mood disorders...
  2. ncbi Glutamate exocytosis from astrocytes controls synaptic strength
    Pascal Jourdain
    Department of Cell Biology and Morphology, University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland
    Nat Neurosci 10:331-9. 2007
    ..Thus, we provide the first combined functional and ultrastructural evidence for a physiological control of synaptic activity via exocytosis of glutamate from astrocytes...
  3. ncbi Glia-derived D-serine controls NMDA receptor activity and synaptic memory
    Aude Panatier
    INSERM, U378, Bordeaux, F 33077, France
    Cell 125:775-84. 2006
    ..Such a contribution of astrocytes to synaptic metaplasticity fuels the emerging concept that astrocytes are dynamic partners of brain signaling...
  4. ncbi NMDA receptor subunits: diversity, development and disease
    S Cull-Candy
    Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK
    Curr Opin Neurobiol 11:327-35. 2001
    ..Recent studies are beginning to address the functional significance of NMDAR diversity under normal and pathological conditions...
  5. ncbi Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain
    C Ikonomidou
    Department of Pediatric Neurology, Charite Virchow Clinics, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Science 283:70-4. 1999
    ..These findings may have relevance to human neurodevelopmental disorders involving prenatal (drug-abusing mothers) or postnatal (pediatric anesthesia) exposure to drugs that block NMDA receptors...
  6. pmc Glutamate antagonists limit tumor growth
    W Rzeski
    Department of Pediatric Neurology, Children's Hospital, Charite-Virchow Campus, Humboldt University, Augustenburger Platz 1, D-13353 Berlin, Germany
    Proc Natl Acad Sci U S A 98:6372-7. 2001
    ..Furthermore, glutamate antagonists decreased motility and invasive growth of tumor cells. These findings suggest anticancer potential of glutamate antagonists...
  7. ncbi Subunit-specific NMDA receptor trafficking to synapses
    Andres Barria
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Neuron 35:345-53. 2002
    ..Thus, as with AMPA-Rs, synaptic trafficking of NMDA-Rs is tightly regulated and has subunit-specific rules with functionally important consequences...
  8. ncbi Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors
    Sungho Maeng
    Laboratory of Molecular Pathophysiology and Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Biol Psychiatry 63:349-52. 2008
    ..Understanding the mechanisms underlying the intriguing effects of N-methyl d-aspartate (NMDA) antagonists could lead to novel treatments with a rapid onset of action...
  9. ncbi Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus
    Thomas E Bartlett
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Neuropharmacology 52:60-70. 2007
    ..4 microM. The lack of effect of 0.1 microM NVP on LTD contrasts with its marked effect on LTP and raises the possibility that different NVP-sensitive NR2 subunit-containing NMDA receptors are required for LTP and LTD in this preparation...
  10. ncbi Expression of glutamate receptor subunits in human cancers
    Andrzej Stepulak
    Department of Biochemistry and Molecular Biology, Medical University of Lublin, Lublin 20 093, Poland
    Histochem Cell Biol 132:435-45. 2009
    ..The potential role of glutamate receptor antagonists in cancer therapy is a feasible goal to be explored in clinical trials...
  11. pmc Enhanced astrocytic Ca2+ signals contribute to neuronal excitotoxicity after status epilepticus
    Shinghua Ding
    Silvio Conte Center for Integration at the Tripartite Synapse, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:10674-84. 2007
    ..These observations support neurotoxic roles for astrocytic gliotransmission in pathological conditions and identify this process as a novel therapeutic target...
  12. ncbi Mechanism of action of memantine
    Jon W Johnson
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Curr Opin Pharmacol 6:61-7. 2006
    ..Because modulation of NMDA receptor activity can increase or decrease excitability of neuronal circuits, subtle differences in the mechanisms of action of NMDA receptor antagonists can strongly impact on their clinical effects...
  13. pmc Tumor necrosis factor-alpha mediates one component of competitive, experience-dependent plasticity in developing visual cortex
    Megumi Kaneko
    Department of Physiology and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94143 0444, USA
    Neuron 58:673-80. 2008
    ....
  14. ncbi Modular competition driven by NMDA receptor subtypes in spike-timing-dependent plasticity
    Richard C Gerkin
    Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
    J Neurophysiol 97:2851-62. 2007
    ..Using a simple model, we show that such a modular competition recapitulates our observations...
  15. ncbi The drugs don't work-or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory
    D M Bannerman
    Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, England
    Psychopharmacology (Berl) 188:552-66. 2006
    ..The aim of this article is to provide a review of studies using N-methyl-D-aspartate (NMDA) receptor antagonists to assess the hippocampal long-term potentiation (LTP)/learning hypothesis...
  16. pmc Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults
    Stuart A Lipton
    The Burnham Institute, and the University of California, San Diego, La Jolla, California 92037, USA
    NeuroRx 1:101-10. 2004
    ..These second-generation drugs take advantage of the fact that the NMDA receptor has other modulatory sites, in addition to its ion channel, that could potentially be used for safe but effective clinical intervention...
  17. pmc In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death
    M A Martel
    Centre for Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
    Neuroscience 158:334-43. 2009
    ..In this instance, subunit differences cannot account for the dichotomous nature of NMDA receptor signaling...
  18. ncbi Effects of ketamine in normal and schizophrenic volunteers
    A C Lahti
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 25:455-67. 2001
    ..This study indicates that NVs could be used for many informative experimental psychosis studies involving ketamine interviews...
  19. pmc Targeting glutamatergic signaling for the development of novel therapeutics for mood disorders
    Rodrigo Machado-Vieira
    Experimental Therapeutics, Mood and Anxiety Disorders Research Program, National Institute of Mental Health NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Curr Pharm Des 15:1595-611. 2009
    ..This paper reviews the currently available knowledge regarding the role of the glutamatergic system in the etiopathogenesis of mood disorders and putative glutamate modulators...
  20. pmc Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: role of NMDA receptor activation and NMDA dependent calcium entry
    Laxmikant S Deshpande
    Department of Neurology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Eur J Pharmacol 583:73-83. 2008
    ....
  21. ncbi Pharmacology and functions of metabotropic glutamate receptors
    P J Conn
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Annu Rev Pharmacol Toxicol 37:205-37. 1997
    ..These findings have exciting implications for drug development and suggest that the mGluRs provide a novel target for development of therepeutic agents that could have a significant impact on neuropharmacology...
  22. pmc Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators
    Timothy M Acker
    Department of Chemistry, Emory University, USA
    Mol Pharmacol 80:782-95. 2011
    ..These data suggest a mechanism for this new class of inhibitors and demonstrate that ligands can access, in a subunit-selective manner, a new site located in the lower, membrane-proximal portion of the agonist-binding domain...
  23. pmc Exposure to cocaine regulates inhibitory synaptic transmission in the nucleus accumbens
    Mami Otaka
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 33:6753-8. 2013
    ....
  24. ncbi Mixed inhibitory synaptic balance correlates with glutamatergic synaptic phenotype in cerebellar unipolar brush cells
    Charly V Rousseau
    Inhibitory Transmission Team, Institut de Biologie de l ENS, IBENS, INSERM, U1024, CNRS, UMR 8197, Paris, F 75005 France
    J Neurosci 32:4632-44. 2012
    ..We propose that slow glycinergic IPSCs may provide an inhibitory tone, setting the gain of the MF to UBC relay, whereas large and fast GABAergic IPSCs may in addition control spike timing in mGluRII-negative UBCs...
  25. ncbi Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy
    R T Ngomba
    Neuromed Institute, Neuropharmacology Unit, Parco Technologico, Località Camerelle 86077, Pozzilli, Isernia, Italy
    Neuropharmacology 60:1281-91. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  26. pmc Different adaptations in AMPA receptor transmission in the nucleus accumbens after short vs long access cocaine self-administration regimens
    Anthony Purgianto
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, IL, USA
    Neuropsychopharmacology 38:1789-97. 2013
    ..Together with data on cocaine infusions in each group, our results show that CP-AMPAR accumulation and enhanced glutamate transmission is associated with longer sessions (6 h), rather than the number of sessions or cocaine infusions...
  27. ncbi D-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learning
    Steven Duffy
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Neuropsychopharmacology 33:1004-18. 2008
    ..By enhancing this form of synaptic plasticity, D-serine could improve cognitive flexibility in psychiatric disorders characterized by perseveration of aberrant ideation or behaviors...
  28. ncbi Glutamate and the neural basis of the subjective effects of ketamine: a pharmaco-magnetic resonance imaging study
    J F William Deakin
    Neuroscience and Psychiatry Unit, The University of Manchester, G 907 Stopford Building, Oxford Rd, Manchester M13 9PT, England
    Arch Gen Psychiatry 65:154-64. 2008
    ..Ketamine evokes psychosislike symptoms, and its primary action is to impair N-methyl-D-aspartate glutamate receptor neurotransmission, but it also induces secondary increases in glutamate release...
  29. ncbi Memantine in moderate-to-severe Alzheimer's disease
    Barry Reisberg
    Department of Psychiatry, New York University School of Medicine, New York 10016, USA
    N Engl J Med 348:1333-41. 2003
    ..Overstimulation of the N-methyl-D-aspartate (NMDA) receptor by glutamate is implicated in neurodegenerative disorders. Accordingly, we investigated memantine, an NMDA antagonist, for the treatment of Alzheimer's disease...
  30. ncbi AMPA silencing is a prerequisite for developmental long-term potentiation in the hippocampal CA1 region
    Therése Abrahamsson
    University of Gothenburg, Department of Physiology, Box 432, Medicinaregatan 11, 405 30 Gothenburg, Sweden
    J Neurophysiol 100:2605-14. 2008
    ..Mature LTP, by instead strengthening existing stable connections between cells, may then create functionally tightly connected cell assemblies within this network...
  31. ncbi Effects of quetiapine on monoamine, GABA, and glutamate release in rat prefrontal cortex
    Satoshi Yamamura
    Department of Psychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Psychopharmacology (Berl) 206:243-58. 2009
    ..The atypical antipsychotic drug, quetiapine (QTP), is effective in schizophrenia and mood disorders, but induces seizures compared to typical antipsychotics...
  32. ncbi Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactions
    Daniel C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric, Research, New York University School of Medicine, Orangeburg, New York 10962, USA
    Int Rev Neurobiol 78:69-108. 2007
    ..Finally, genetic linkage and in vivo neurochemical studies in schizophrenia highlight potential etiological mechanisms giving rise to glutamatergic/NMDA dysfunction in schizophrenia...
  33. pmc AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss
    Helen Hsieh
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Neuron 52:831-43. 2006
    ..Our studies indicate the central role played by AMPA receptor trafficking in Abeta-induced modification of synaptic structure and function...
  34. ncbi Interaction of mGlu2/3 agonism with clozapine and lurasidone to restore novel object recognition in subchronic phencyclidine-treated rats
    Masakuni Horiguchi
    Division of Psychopharmacology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Psychopharmacology (Berl) 217:13-24. 2011
    ..Atypical antipsychotic drugs (APDs) reverse the effects of subchronic PCP on NOR. The effect of metabotropic glutamate₂/₃ receptor (mGlu₂/₃) agonists upon NOR is unknown...
  35. ncbi Differential cAMP signaling at hippocampal output synapses
    Christian Wozny
    Neuroscience Research Center, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    J Neurosci 28:14358-62. 2008
    ..Our results provide evidence for a differential role of cAMP in LTP at hippocampal output synapses...
  36. ncbi NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo
    Yitao Liu
    Brain Research Centre, Vancouver Coastal Health Research Institute and University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5
    J Neurosci 27:2846-57. 2007
    ....
  37. pmc A refractory period for rejuvenating GABAergic synaptic transmission and ocular dominance plasticity with dark exposure
    ShiYong Huang
    The Mind Brain Institute, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neurosci 30:16636-42. 2010
    ....
  38. pmc CDK5 serves as a major control point in neurotransmitter release
    Sung Hyun Kim
    Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA
    Neuron 67:797-809. 2010
    ..These studies thus pinpoint CDK5 as a major control point for modulation of neurotransmitter release in mammalian neurons...
  39. ncbi Effects of memantine on behavioural symptoms in Alzheimer's disease patients: an analysis of the Neuropsychiatric Inventory (NPI) data of two randomised, controlled studies
    S Gauthier
    MCSA Alzheimer s Disease Research Unit, McGill Centre for Studies in Aging, Quebec, Canada
    Int J Geriatr Psychiatry 20:459-64. 2005
    ..We have analysed the databases of two randomised studies with regard to the effects of memantine treatment on behavioural symptoms, measured using the 12-item version of the Neuropsychiatric Inventory (NPI)...
  40. ncbi The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801
    G Rammes
    Clinical Neuropharmacology, Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804 Munich, Germany
    Neuropharmacology 40:749-60. 2001
    ....
  41. ncbi PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis
    Rong Rong
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Room 145, Whitehead Building, 615 Michael Street, Atlanta, Georgia 30322, USA
    Nat Neurosci 6:1153-61. 2003
    ..Our findings indicate that this complex mediates the well-known ability of agonists of mGluRI to prevent neuronal apoptosis...
  42. ncbi Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity
    Lidong Liu
    Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
    Science 304:1021-4. 2004
    ..These results demonstrate that distinct NMDAR subunits are critical factors that determine the polarity of synaptic plasticity...
  43. ncbi Mesocortical dopamine neurons operate in distinct temporal domains using multimodal signaling
    Antonieta Lavin
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 25:5013-23. 2005
    ....
  44. pmc Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors
    Paul M Lea
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057 2197, USA
    Br J Pharmacol 145:527-34. 2005
    ..5 Combined, these studies support the conclusion that MTEP has greater mGluR5 selectivity than MPEP, and that neuroprotection provided by either antagonist in neuronal cultures does not reflect inhibition of mGluR5 receptors...
  45. pmc Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices
    Alexander Z Harris
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Ave, K426, Bronx, NY 10461, USA
    J Physiol 584:509-19. 2007
    ..Our data suggest that any role played by extrasynaptic NMDARs in synaptic transmission is dictated by their subcellular location rather than their subunit composition or mobility...
  46. ncbi Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex
    Anthony Burgos-Robles
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 00732
    Neuron 53:871-80. 2007
    ..We suggest that NMDAR-dependent bursting in the infralimbic vmPFC initiates calcium-dependent molecular cascades that stabilize extinction memory, thereby allowing for successful recall of extinction...
  47. ncbi Glutamatergic animal models of schizophrenia
    Bita Moghaddam
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Ann N Y Acad Sci 1003:131-7. 2003
    ..The present chapter includes a brief review of the utility of these models and the search for new medications that have the potential of normalizing glutamate neurotransmission in schizophrenia...
  48. pmc Mechanisms and time course of vocal learning and consolidation in the adult songbird
    Timothy L Warren
    Keck Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, California 94143 0444, USA
    J Neurophysiol 106:1806-21. 2011
    ..The results support an emerging view that cortical-basal ganglia circuits can direct the initial expression of learning via top-down influences on primary motor circuitry...
  49. ncbi The role of serotonin in the NMDA receptor antagonist models of psychosis and cognitive impairment
    Herbert Y Meltzer
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Psychopharmacology (Berl) 213:289-305. 2011
    ..g., phencyclidine (PCP), dizocilpine (MK-801), and ketamine, to stimulate locomotor activity (LA), and to impair novel object recognition (NOR)...
  50. ncbi Role of p/q-Ca2+ channels in metabotropic glutamate receptor 2/3-dependent presynaptic long-term depression at nucleus accumbens synapses
    David Robbe
    Centre National de la Recherche Scientifique Unité Propre de Recherche 9023, Unité Mixte de Recherche 5101, and Unité Propre de Recherche 1142, 34094 Montpellier Cedex 05, France
    J Neurosci 22:4346-56. 2002
    ....
  51. pmc AMPA receptor synaptic plasticity induced by psychostimulants: the past, present, and therapeutic future
    M Scott Bowers
    Virginia Institute for Psychiatric and Behavioral Genetics, VCU Psychiatry, Richmond, VA 23284, USA
    Neuron 67:11-24. 2010
    ..Finally, we review clinical trials that highlight antagonists at excitatory AMPA receptors as promising targets against cocaine abuse...
  52. ncbi Retrograde activation of presynaptic NMDA receptors enhances GABA release at cerebellar interneuron-Purkinje cell synapses
    Ian C Duguid
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 7:525-33. 2004
    ..Thus, NMDA receptor-mediated facilitation of transmission at this synapse provides a regulatory mechanism that can dynamically alter the synaptic efficacy at inhibitory synapses...
  53. ncbi Amphetamine increases phosphorylation of extracellular signal-regulated kinase and transcription factors in the rat striatum via group I metabotropic glutamate receptors
    Eun Sang Choe
    Division of Pharmacology, School of Pharmacy, University of Missouri Kansas City, 2411 Holmes St, M3 C15, Kansas City, MO 64108, USA
    Neuropsychopharmacology 27:565-75. 2002
    ..These data suggest that acute amphetamine is able to facilitate the phosphorylation of CREB, Elk-1, and ERK1/2 signaling proteins and Fos gene expression via a group I mGluR-dependent mechanism in the dorsal striatum...
  54. pmc N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse
    Blaise Mathias Costa
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5800, USA
    J Pharmacol Exp Ther 331:618-26. 2009
    ..UBP125, UBP128, UBP141, and UBP145 may be useful tools for determining the function of NMDA receptor subtypes...
  55. pmc Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease
    O L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 80:600-7. 2009
    ..There are no long-term studies of the effects of memantine in combination with ChEIs use in Alzheimer disease (AD). This study was conducted to examine the effects of ChEIs and memantine on time to death and time to NH admission...
  56. pmc Extrasynaptic NR2D-containing NMDARs are recruited to the synapse during LTP of NMDAR-EPSCs
    Sarah C Harney
    Department of Physiology, Trinity College, Dublin 2, Ireland
    J Neurosci 28:11685-94. 2008
    ..Our results show that LTP of NMDAR-EPSCs involves movement of NMDARs from an extrasynaptic to a synaptic location and suggest a novel physiological role for extrasynaptic NMDARs...
  57. pmc Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
    Hiroyasu Furukawa
    Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA
    EMBO J 22:2873-85. 2003
    ..In addition, the NR1 S1S2 structure reveals the fold and interactions of loop 1, a cysteine-rich region implicated in intersubunit allostery...
  58. ncbi Dissociable contribution of 5-HT1A and 5-HT2A receptors in the medial prefrontal cortex to different aspects of executive control such as impulsivity and compulsive perseveration in rats
    Mirjana Carli
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Neuropsychopharmacology 31:757-67. 2006
    ....
  59. ncbi The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons
    Limin Mao
    Department of Basic Medical Science, University of Missouri Kansas City, School of Medicine, Kansas City, Missouri 64108, USA
    J Neurosci 25:2741-52. 2005
    ..Both the Ca2+-dependent and -independent pathways are corequired to activate ERK1/2 to a level sufficient to achieve the mGluR5-dependent synapse-to-nucleus communication imperative for the transcriptional regulation...
  60. ncbi Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?
    Chrysanthy Ikonomidou
    Department of Pediatric Neurology, Children s Hospital, Charité Virchow Campus, Humboldt University, Berlin, Germany
    Lancet Neurol 1:383-6. 2002
    ..We propose that NMDA receptor antagonists failed stroke and traumatic brain injury trials in human beings because blockade of synaptic transmission mediated by NMDA receptors hinders neuronal survival...
  61. ncbi Inhibition of paclitaxel-induced A-fiber hypersensitization by gabapentin
    Misaki Matsumoto
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Pharmacol Exp Ther 318:735-40. 2006
    ....
  62. ncbi Blockade of N-methyl-D-aspartate receptors by ketamine produces loss of postnatal day 3 monkey frontal cortical neurons in culture
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research Food and Drug Administration, Jefferson, Arkansas 72079 0502, USA
    Toxicol Sci 91:192-201. 2006
    ..Ketamine-induced effects were blocked by NR1 antisenses and SN-50. These data suggest that NR1 antisenses and SN-50 offer neuroprotection from the enhanced degeneration induced by ketamine in vitro...
  63. ncbi NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII
    Andres Barria
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Neuron 48:289-301. 2005
    ..The switch from NR2B to NR2A content in synaptic NMDA-Rs normally observed in many brain regions may contribute to reduced plasticity by controlling the binding of active CaMKII...
  64. ncbi Effects of ketamine on anterior cingulate glutamate metabolism in healthy humans: a 4-T proton MRS study
    Laura M Rowland
    Department of Psychiatry, MIND Imaging Center, University of New Mexico, USA
    Am J Psychiatry 162:394-6. 2005
    ..The authors' goal was to test in humans the hypothesis that N-methyl-d-aspartate receptor (NMDAR) antagonism results in increased cortical glutamate activity, as proposed by the NMDAR hypofunction model of schizophrenia...
  65. pmc Psychological effects of ketamine in healthy volunteers. Phenomenological study
    E Pomarol-Clotet
    Benito Menni CASM, Barcelona, Spain
    Br J Psychiatry 189:173-9. 2006
    ..The psychosis-inducing effect of ketamine is important evidence supporting the glutamate hypothesis of schizophrenia. However, the symptoms the drug produces have not been described systematically...
  66. ncbi Non-associative learning in larval zebrafish
    Jonathan D Best
    DanioLabs Ltd a wholly owned subsidiary of VASTox plc, Unit 7330, Cambridge Research Park, Cambridge, UK
    Neuropsychopharmacology 33:1206-15. 2008
    ..Zebrafish larvae possess numerous advantages for medium to high-throughput screening; the model described herein therefore offers the potential to screen for additional compounds for further study on cognition function...
  67. ncbi Glutamate transporter dysfunction associated with nerve injury-induced pain in mice
    Ian A Napier
    Discipline of Pharmacology, University of Sydney, New South Wales, Australia
    J Neurophysiol 107:649-57. 2012
    ..Together, these results suggest the development of neuropathic pain involves subtle changes to glutamate transporter expression and function that could contribute to neuropathic pain during excessive synaptic activity...
  68. pmc Blockade of cochlear NMDA receptors prevents long-term tinnitus during a brief consolidation window after acoustic trauma
    Matthieu J Guitton
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Neural Plast 2007:80904. 2007
    ..Furthermore, this finding paves the way to potential therapeutic strategies for the prevention of chronic tinnitus once the noise insult had taken place...
  69. ncbi A horizontal slice preparation for examining the functional connectivity of dorsal column fibres in mouse spinal cord
    Jamie R Flynn
    School of Biomedical Sciences and Pharmacy, Faculty of Health and Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW 2308, Australia
    J Neurosci Methods 200:113-20. 2011
    ..This preparation is a potentially valuable tool for SCI research where confirmation of regenerated, functional synapses across a spinal lesion is critical...
  70. ncbi The relationship between NMDA receptor function and the high ammonia tolerance of anoxia-tolerant goldfish
    Michael P Wilkie
    Department of Biology, Wilfrid Laurier University, Waterloo, ON, Canada
    J Exp Biol 214:4107-20. 2011
    ..We conclude that the goldfish brain may be protected from excitotoxicity by downregulating the abundance of functional NMDA receptors during periods when it experiences increased internal ammonia...
  71. pmc Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid
    Bihua Feng
    Department of Pharmacology, University of Nebraska Medical Center, Omaha, NE 68198 6260, U S A
    Br J Pharmacol 141:508-16. 2004
    ..British Journal of Pharmacology (2004) 141, 508-516. doi:10.1038/sj.bjp.0705644..
  72. ncbi Acute and chronic effects of ketamine upon human memory: a review
    Celia J A Morgan
    Clinical Psychopharmacology Unit, Sub Department of Clinical Health Psychology, University College London, Gower Street, London, WC1E 6BT, UK
    Psychopharmacology (Berl) 188:408-24. 2006
    ..Ketamine is attracting increasing research interest not only because of its powerful amnestic effects but also as a putative model of schizophrenia and as a substance with an expanding following of recreational users...
  73. ncbi Corticosterone acutely prolonged N-methyl-d-aspartate receptor-mediated Ca2+ elevation in cultured rat hippocampal neurons
    Taiki Takahashi
    Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan
    J Neurochem 83:1441-51. 2002
    ..These results imply that high levels of CORT induce a rapid and non-genomic prolongation of NMDA receptor-mediated Ca2+ elevation, probably via putative membrane surface receptors for CORT in the hippocampal neurons...
  74. ncbi Endocannabinoids mediate neuron-astrocyte communication
    Marta Navarrete
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    Neuron 57:883-93. 2008
    ..They also reveal the existence of an endocannabinoid-glutamate signaling pathway where astrocytes serve as a bridge for nonsynaptic interneuronal communication...
  75. ncbi Memantine therapy for Alzheimer disease in real-world practice: an observational study in a large representative sample of French patients
    Jean Sébastien Vidal
    Institut National de la Santé et de la Recherche Médicale INSERM U708, Paris, France
    Alzheimer Dis Assoc Disord 22:125-30. 2008
    ..Approximately one-third of the memantine-treated patients did not strictly fit with the French summary of product characteristic recommendations for the first memantine prescription...
  76. ncbi Low doses of memantine disrupt memory in adult rats
    Catherine Creeley
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:3923-32. 2006
    ..We conclude that, in the adult rat, memantine behaves like other NMDA antagonists in that it is neuroprotective only at doses that produce intolerable side effects, including memory impairment...
  77. ncbi Effects of mGluR5 and mGluR1 antagonists on anxiety-like behavior and learning in developing rats
    Anna Mikulecká
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, CZ 142 20 Prague 4, Czech Republic
    Behav Brain Res 204:133-9. 2009
    ..Both MPEP and AIDA exert anxiolytic-like effect also in immature rats. Except for the youngest animals no changes in learning ability in the homing response test were found...
  78. ncbi A plateau potential mediated by the activation of extrasynaptic NMDA receptors in rat hippocampal CA1 pyramidal neurons
    Takayuki Suzuki
    Laboratory of Cellular Neurobiology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192 0392, Japan
    Eur J Neurosci 28:521-34. 2008
    ..These results show that CA1 pyramidal neurons generate plateau potentials mediated most likely by activation of extrasynaptic NMDARs...
  79. pmc Mg2+ imparts NMDA receptor subtype selectivity to the Alzheimer's drug memantine
    Shawn E Kotermanski
    Department of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 29:2774-9. 2009
    ....
  80. ncbi Dynamics of spontaneous activity in neocortical slices
    B Q Mao
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Neuron 32:883-98. 2001
    ..We conclude that the isolated neocortical microcircuit generates spontaneous activity, mediated by a combination of intrinsic and circuit mechanisms, and that this activity can be temporally precise...
  81. ncbi A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death
    Simona D'Antoni
    Institute of Neurological Sciences, National Research Council, via P Gaifami 18, 95126 Catania, Italy
    Neurobiol Dis 42:252-64. 2011
    ..The protective effect of MPEP was absent in cultures with a reduced number of astrocytes. We suggest that blocking astrocytic mGlu5 receptors is a potential therapeutic strategy in ALS...
  82. ncbi Electrophysiological characterisation of the actions of kynurenic acid at ligand-gated ion channels
    M H Selina Mok
    Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex CM19 5AW, United Kingdom
    Neuropharmacology 57:242-9. 2009
    ..In conclusion, kynA is an antagonist at NMDA, AMPA and glycine receptors and a modulator of GABA(A) receptors, but we find no evidence for any effect of kynA at the alpha7 nAChR...
  83. ncbi Glutamatergic theories of schizophrenia
    Daniel C Javitt
    Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research New York University Langone School of Medicine, Orangeburg, New York 10962, USA
    Isr J Psychiatry Relat Sci 47:4-16. 2010
    ..Overall, these findings suggest that glutamatergic theories may lead to new conceptualizations and treatment approaches that would not be possible based upon dopaminergic models alone...
  84. pmc Phencyclidine and dizocilpine induced behaviors reduced by N-acetylaspartylglutamate peptidase inhibition via metabotropic glutamate receptors
    Rafal T Olszewski
    Department of Biology, Georgetown University, Washington D C 20057, USA
    Biol Psychiatry 63:86-91. 2008
    ..We previously reported that ZJ43, a potent inhibitor of the enzymes that inactivate synaptically released NAAG, reduced motor and stereotypic effects of PCP in the rat...
  85. ncbi Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors
    Ezio Bettini
    Screening and Compound Profiling, GlaxoSmithKline Medicines Research Centre, Verona, Italy
    J Pharmacol Exp Ther 335:636-44. 2010
    ....
  86. ncbi Stress-induced hyperthermia: effects of acute and repeated dosing of MPEP
    Rebecca E Nordquist
    F Hoffmann La Roche Ltd, PRBD N, Psychiatry Disease Area, CH 4070 Basel, Switzerland
    Eur J Pharmacol 568:199-202. 2007
    ..MPEP remained equally active in reducing stress-induced hyperthermia after five daily treatments with 30 mg/kg, further validating MPEP as a potential anxiolytic for chronic use...
  87. ncbi Differential effects of the N-methyl-d-aspartate receptor antagonist MK-801 on different stages of object recognition memory in mice
    M Nilsson
    Institute of Neuroscience and Physiology, Goteborg University, Medicinaregatan 11, SE 405 30 Goteborg, Sweden
    Neuroscience 149:123-30. 2007
    ..Alternatively, the phencyclidine-like, psychotogenic properties of MK-801 could result in an amplification of the perceived salience of the novel object, and/or anxiolytic mechanisms could result in neophilic effects...
  88. ncbi Memantine blocks alpha7* nicotinic acetylcholine receptors more potently than n-methyl-D-aspartate receptors in rat hippocampal neurons
    Yasco Aracava
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 655 West Baltimore St, Baltimore, MD 21201, USA
    J Pharmacol Exp Ther 312:1195-205. 2005
    ..It is suggested that blockade of alpha7(*) nAChRs by memantine could decrease its effectiveness for treatment of AD, particularly at early stages when the degrees of nAChR dysfunction and of cognitive decline correlate well...
  89. ncbi Glutamatergic approaches in major depressive disorder: focus on ketamine, memantine and riluzole
    R T Owen
    Drugs Today (Barc) 48:469-78. 2012
    ..Although preclinical studies are discussed, the main focus of the review is on clinical outcomes...
  90. ncbi An NMDA receptor/nitric oxide cascade is involved in cerebellar LTD but is not localized to the parallel fiber terminal
    Jung Hoon Shin
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Neurophysiol 94:4281-9. 2005
    ..These results are consistent with the hypothesis that an NMDA receptor/NO cascade involved in cerebellar LTD is localized to interneurons rather than parallel fibers...
  91. pmc Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro
    Sergey Neyman
    Institute for Physiology of the Charite, Synaptic Plasticity Research Group, Humboldt University, Berlin, Germany
    Eur J Neurosci 27:1345-52. 2008
    ..Taken together, these data support the notion that both mGluR1 and mGluR5 are critically involved in bidirectional synaptic plasticity in the CA1 region and may enable functional differences in information encoding through LTP and LTD...
  92. pmc Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Neurotherapeutics 6:94-107. 2009
    ..This review examines the multipotential therapeutic utility of mGluR modulation in acute and chronic injury and neurodegeneration...
  93. pmc Family history of alcohol dependence and initial antidepressant response to an N-methyl-D-aspartate antagonist
    Laura E Phelps
    Laboratory of Molecular Pathophysiology and Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892 1282, USA
    Biol Psychiatry 65:181-4. 2009
    ..This study investigated whether a family history of alcohol dependence influences ketamine's initial antidepressant effect...
  94. ncbi Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model
    Tatsuo Yamamoto
    Department of Anaesthesiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba shi, Chiba 260 8670, Japan
    Eur J Neurosci 20:483-94. 2004
    ..In contrast, peptidase inhibition did not affect the threshold for withdrawal from a noxious mechanical stimulus or from an acute thermal stimulus in the hotplate test...
  95. pmc Cardiovascular function of a glutamatergic projection from the hypothalamic paraventricular nucleus to the nucleus tractus solitarius in the rat
    T Kawabe
    Department of Neurological Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Neuroscience 153:605-17. 2008
    ....
  96. ncbi Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD
    F Bibbiani
    ETB, NINDS, National Institutes of Health, Bethesda, MD 20892, USA
    Exp Neurol 196:422-9. 2005
    ....
  97. ncbi The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors
    Zuner A Bortolotto
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Neuropharmacology 49:13-25. 2005
    ..In addition, the mGlu5 selective agonist CHPG ((RS)-2-chloro-5-hydroxyphenylglycine) sets the molecular switch. These data demonstrate that the operation of the molecular switch requires activation of mGlu5 receptors...
  98. pmc The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior
    Jing Du
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20878, USA
    J Neurosci 28:68-79. 2008
    ..These studies provide novel insights into the role of hippocampal GluR1/2 receptors in mediating facets of the manic syndrome and offer avenues for the development of novel therapeutics for these disorders...
  99. ncbi Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms
    Claudia Rosin
    Neuro Cell Sciences, Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research and Development Limited, Harlow, Essex, UK
    J Neurochem 90:1173-85. 2004
    ..Glutamate toxicity may conceivably be operative in neuropathological conditions that disrupt neuronal/oligodendrocyte interactions in axons, e.g. multiple sclerosis and ischaemia-reperfusion injury...
  100. ncbi Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn
    S Boyce
    Merck Sharp Laboratory, Neuroscience Research Centre, Harlow, UK
    Neuropharmacology 38:611-23. 1999
    ..These findings demonstrate that NR2B antagonists may have clinical utility for the treatment of neuropathic and other pain conditions in man with a reduced side-effect profile than existing NMDA antagonists...
  101. ncbi Long-lasting NMDA receptor-mediated EPSCs in mouse striatal medium spiny neurons
    Stephen M Logan
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Neurophysiol 98:2693-704. 2007
    ..Our data are consistent with the expression of a unique NMDA receptor complex in MSNs with very slow deactivation kinetics...

Research Grants64

  1. Arcuate nucleus glutamatergic neurons modulate energy homeostasis
    Anthony N van den Pol; Fiscal Year: 2013
    ..abstract_text> ..
  2. Glutamate, aging and enriched environment after dopamine loss
    CHARLES KENNETH MESHUL; Fiscal Year: 2013
    ....
  3. ACTIVITY OF BRAINSTEM NEURONS
    Nae J Dun; Fiscal Year: 2010
    ....
  4. Synaptic Phenotype, Development, and Plasticity in the Fragile X Mouse
    CHARLES LEROY COX; Fiscal Year: 2013
    ..Ultimately, we are asking how abnormalities in spine morphology, found in the majority of causes of mental retardation, relate to behavioral function and cognition. ..
  5. Canonical Transient Receptor Potential Channels and Excitotoxicity
    Fang Zheng; Fiscal Year: 2010
    ..In addition, the signaling studies mentioned in the abstract have been deleted. All else has remained the same since the proposed experiments to remain in the grant address the original scope of the grant. ..
  6. Neuroprotection by Allopregnanolone through Modulation of GABAA Receptors
    MELISSA HERNANDEZ KELLEY; Fiscal Year: 2010
    ....
  7. Balanced, polyvalent antiglutamatergic action as a novel approach to efficacious
    Anatoly Martynyuk; Fiscal Year: 2009
    ....
  8. STRESS GENES AND HEMORRHAGIC BRAIN INJURY
    Frank Sharp; Fiscal Year: 2001
    ..These studies will help delineate mechanisms of injury following subarachnoid hemorrhage, and will develop a new approach for assessing whether drugs decrease or block injury due to subarachnoid hemorrhage. ..
  9. DIURETIC PROTECTION FROM ALCOHOL INDUCED BRAIN DAMAGE
    Michael Collins; Fiscal Year: 1999
    ....
  10. EXCITOTOXIC MECHANISMS IN POST TRAUMATIC NEURONAL DEATH
    Douglas Ross; Fiscal Year: 1992
    ....
  11. Volatile Anesthetic Action in Vertebrate Locomotor Systems
    Steven L Jinks; Fiscal Year: 2010
    ..Results from these projects will increase our understanding of how and where anesthetics act in the nervous system, contributing to the development of safer anesthetics and clinical practices. ..
  12. PERIPHERAL & CENTRAL SUBSTRATES OF PRIMARY HYPERALGESIA
    Alan Randich; Fiscal Year: 2000
    ....
  13. Basal ganglia discharge patterns in parkinsonism
    Thomas Wichmann; Fiscal Year: 2005
    ....
  14. ROLE OF NUCLEUS ACCUMBENS CA2+ FLUX IN COCAINE REWARD
    WILLIAM CARLEZON; Fiscal Year: 2000
    ..Understanding how factors such as intra-NASh Ca2+ flux are involved in cocaine's subjective effects will help to identify neural targets toward which potential treatments for cocaine addiction and craving could be directed. ..
  15. AGMATINASE INHIBITORS FOR HYPOXIC-ISCHEMIC NEW BORN BRAIN DAMAGE
    John Piletz; Fiscal Year: 2007
    ..The overall goal of these studies is to develop a treatment for perinatal brain damage in human infants. [unreadable] [unreadable] [unreadable]..
  16. EXCITOTOXICITY IN CIRCULATORY ARREST--BRAIN INJURY
    William Baumgartner; Fiscal Year: 2000
    ..The ability to provide cerebral protection could result in better patient outcomes after circulatory arrest during cardiothoracic procedures. ..
  17. Glutamate Induced Molecular Events Contributing to Chro*
    KARIN WESTLUND HIGH; Fiscal Year: 2002
    ....
  18. Homer Upregulation During Instrumental Learning in the Dorsomedial Striatum
    Brenda L McKee; Fiscal Year: 2010
    ..Understanding the neural substrates of addiction will help to produce treatments for this devastating disease. ..
  19. COX-2 and Injury in the Immature Brain
    Robert Hickey; Fiscal Year: 2005
    ..g., NSAIDS, steroids, etc.) can influence COX-2 production and isoform-specific COX-2 inhibitors have recently become clinically available. ..
  20. GLUTAMATERIC MECHANISMS OF DRUG-CONDITIONED BEHAVIOR
    Robert Balster; Fiscal Year: 2004
    ....
  21. In vivo proof of concept:pH-dependent neuroprotection
    Mark Washburn; Fiscal Year: 2004
    ..The intensity and duration of seizure state will be assessed behaviorally, and the extent of neuronal injury will be measured three days later. ..
  22. PROPAGATION OF INJURY DUE TO FOCAL CEREBRAL ISCHEMIA
    Philip Weinstein; Fiscal Year: 1999
    ..Methods will be developed to identify the "penumbra" around an infarction in the living brain which may be rescued by therapeutic intervention. ..
  23. Development and Testing of a Neuroprotective Solution
    Yanming Wang; Fiscal Year: 2003
    ..At completion of Phase 1 and Phase 2 work, we will apply for an Investigative New Drug (IND). ..
  24. MECHANISMS OF TISSUE DESTRUCTION IN CHOLESTEATOMA
    BRIAN FADDIS; Fiscal Year: 2007
    ..abstract_text> ..
  25. Lesion Induced Synaptic Plasticity
    STEPHEN GINSBERG; Fiscal Year: 2004
    ..hypothesis is challenged by examining granule cell expression profiles following the delivery of excitatory amino acid antagonists prior to PP transections...
  26. PERINATAL BRAIN DAMAGE--MECHANISMS AND PREVENTION
    John Olney; Fiscal Year: 1990
    ....
  27. Ion channel role-glutamate-independent neuronal injury
    Zhigang Xiong; Fiscal Year: 2006
    ..abstract_text> ..
  28. Opioids & plasticity in regulation of serotonin release
    Rui Tao; Fiscal Year: 2004
    ....
  29. EXCITOTOXICITY IN CIRCULATORY ARREST--BRAIN INJURY
    William Baumgartner; Fiscal Year: 2007
    ....
  30. CHOLINERGIC REGULATION IN THE HYPOTHALAMUS
    Andrei Belousov; Fiscal Year: 2009
    ..Data obtained here may have an important clinical relevance, given that glutamate receptor antagonists are used for chronic treatment of patients, and some glutamate receptor antagonists are drugs of abuse. ..
  31. PHARMACOLOGIC REDUCTION OF HYPOXIC NEURONAL INJURY
    Dennis Choi; Fiscal Year: 1992
    ..Information gathered during this study will likely be helpful in guiding testing in vivo, and furthermore should produce insight into the basic nature of EAA involvement in HNI...
  32. MECHANISMS OF POSTOPERATIVE PAIN
    Timothy Brennan; Fiscal Year: 2001
    ..horn neuron threshold, receptive field size and background activity before and after incision; the effect of excitatory amino acid antagonists on the hyperalgesia; and the effect of the same antagonists on the sensitized spinal neurons.
  33. Dendrite Growth and Synaptogenesis in Zebrafish CNS
    Stephen Smith; Fiscal Year: 2007
    ..In addition, the developmental insights obtained may point to unexpected therapeutic opportunities for treating disorders of vision, and repairing effects of neurological trauma, neurodegeneration, and drug addiction. ..
  34. APOPTOSIS IN TRAUMATIC SPINAL CORD INJURY
    Joe Springer; Fiscal Year: 2003
    ..The outcome of these studies will have clear clinical implications for minimizing secondary neuronal and glial cell death and promoting recovery of function following SCI. ..
  35. ALTERED EXCITABILITY OF EPILEPTIC NEURONS
    Istvan Mody; Fiscal Year: 2000
    ..Its magnitude will be evaluated by measuring the effect of excitatory amino acid antagonists on inhibitory postsynaptic currents recorded in the whole- cell mode in brain slices, and will be ..
  36. Effects of Cocaine on the Dorsolateral Striatum
    BRENDA MCKEE; Fiscal Year: 2005
    ..Knowledge of the short and long term effects of a single cocaine exposure could promote a better understanding of cocaine use by humans. ..
  37. PROTON MRS STUDIES IN GENERALIZED ANXIETY DISORDER
    Sanjay Mathew; Fiscal Year: 2008
    ..A specific long-term goal is for the candidate to develop sufficient expertise in MRS to sustain valid and creative application to problems of GAD and related conditions. ..
  38. Calcium Homeostasis and Neonatal Brain Injury
    Christopher Turner; Fiscal Year: 2009
    ....
  39. Glucocorticoids and Apoptosis of Cerebellar Neural Progenitor Cells
    Nuri Farber; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  40. Neurodevelopmental Apoptosis
    Nuri Farber; Fiscal Year: 2008
    ..abstract_text> ..
  41. Treating Asthma Patients with Major Depressive Disorder
    E Sherwood Brown; Fiscal Year: 2004
    ....
  42. Dendritic Processing in the Olfactory Bulb
    Jason Christie; Fiscal Year: 2003
    ..The specific aims are: (1) to determine the function of autoexcitation in mitral cell processing and (2) to determine how dendritic compartmentalization effects mitral cell processing. ..
  43. Effects of antipsychotic drugs on brain and behavior
    FRANK TARAZI; Fiscal Year: 2005
    ..adult rats, and should evolve new principles for improved treatments for childhood-onset schizophrenia and other major pediatric psychiatric disorders. ..
  44. NPY DEPRESSION OF HIPPOCAMPAL EPILEPSY
    Anthony van den Pol; Fiscal Year: 2002
    ..NPY is potentially of great interest because its primary action in the normal hippocampus appears to be one of depressing hyperexcited neurons, without a substantial effect on normal neurotransmission. ..
  45. Cannabinoid Regulation of Basal Ganglia Glutamate and GABA
    SCOTT RAWLS; Fiscal Year: 2007
    ..Our outcomes will be a first step in determining whether blocking endocannabinoid inactivation offers any therapeutic advantage over direct activation of cannabinoid receptors with marijuana. [unreadable] [unreadable] [unreadable]..
  46. Nornicotine for Treatment of Pain
    JOSEPH HOLTMAN; Fiscal Year: 2007
    ..This research project focuses on the development of a novel analgesic agent, nornicotine, for pain management. [unreadable] [unreadable] [unreadable]..
  47. Cytomegalovirus in the Brain
    Anthony N van den Pol; Fiscal Year: 2010
    ..These experiments will help us understand the mechanisms associated with CMV-induced neurological dysfunction, and how to combat the virus within the brain with minimal complications. ..
  48. Chemokines and Macrophages in HIV Neuronal Apoptosis
    Stuart Lipton; Fiscal Year: 2003
    ..Neuronal apoptosis due to gp120 or chemokines will be monitored using several approaches. ..
  49. RETINAL GANGLION CELLS: ION CHANNELS & TRANSMITTERS
    Stuart A Lipton; Fiscal Year: 2010
    ..To characterize the ligand-binding site of NR3-containing receptors, and use information from [2] and [3] to distinguish expression of NR1/NR3 "doublet" receptors from NR1/NR2/NR3 "triplet" receptors on RGCs. ..
  50. S-Nitrosylation of Matrix Metalloproteinases in AIDS
    Stuart Lipton; Fiscal Year: 2007
    ..In the future, the work proposed here may lead to new therapeutic targets based on the novel extracellular signaling pathway involving NO-related molecules and the MMPs that will be studied. ..
  51. Norepinephrine Transporters: Targets for ADHD
    FRANK TARAZI; Fiscal Year: 2004
    ..Expected findings should lead to novel compounds that can be developed as much needed innovative non-stimulant treatments for ADHD and other major neuropsychiatric disorders. ..
  52. Naltrexone for Bipolar Disorder and Alcohol Dependence
    E Sherwood Brown; Fiscal Year: 2006
    ..Alcohol use is the primary outcome, and alcohol craving is the secondary outcome. Manic and depressive symptom severity and the relationship between changes in alcohol use and changes in mood will be expIored. ..
  53. Morphine/NMDA interactions: Antinociceptive and discriminative stimulus effects
    BRADFORD FISCHER; Fiscal Year: 2007
    ..Findings from these experiments may have important clinical implications, and may lead to new pharmacotherapeutic strategies in the treatment of pain and drug abuse. [unreadable] [unreadable] [unreadable]..
  54. Ethanol Effects in the Mammalian Circadian Clock
    Rebecca Prosser; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  55. ERYTHROPOIETIN-INDUCED NEUROPROTECTION
    Stuart Lipton; Fiscal Year: 2005
    ....
  56. Annual Meeting of the American Pain Society
    Linda Sorkin; Fiscal Year: 2005
    ..Abstracts will be judged on scientific merit and published in The Journal of Pain. We believe that these awards will encourage meeting attendance by trainees. ..
  57. Can beta-lactam antibiotics decrease morphine physical dependence?
    SCOTT RAWLS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  58. Mechanisms Underlying the Cognitive Function of Sleep
    Subimal Datta; Fiscal Year: 2009
    ....
  59. HIPPOCAMPAL FUNCTION DURING CORTICOSTEROID THERAPY
    E Sherwood Brown; Fiscal Year: 2004
    ..Through this award, the Pl will extend his previous research experience by adding new skills and knowledge which will be used for investigations at the interface of neuroscience and clinical research. ..
  60. Mechanisms Underlying Rhythm Generation in Identified Spinal Interneurons in Mice
    Lea Ziskind Conhaim; Fiscal Year: 2010
    ....