dopamine uptake inhibitors

Summary

Summary: Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake.

Top Publications

  1. ncbi Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum
    Arvind Kumar
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Neuron 48:303-14. 2005
  2. ncbi Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum
    David Belin
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Neuron 57:432-41. 2008
  3. ncbi Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction
    Nora D Volkow
    National Institute on Alcohol Abuse and Alcoholism, Bethesda Maryland 20892, USA
    J Neurosci 26:6583-8. 2006
  4. pmc Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
    Quincey LaPlant
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 13:1137-43. 2010
  5. pmc Cocaine regulates MEF2 to control synaptic and behavioral plasticity
    Suprabha Pulipparacharuvil
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9127, USA
    Neuron 59:621-33. 2008
  6. pmc In vivo cocaine experience generates silent synapses
    Yanhua H Huang
    Program in Neuroscience, Washington State University, Pullman, WA 99164 6520, USA
    Neuron 63:40-7. 2009
  7. ncbi Critical involvement of dopaminergic neurotransmission in impulsive decision making
    Marcel M van Gaalen
    Department of Medical Pharmacology, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, Free University Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 60:66-73. 2006
  8. ncbi The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 163:362-80. 2002
  9. ncbi Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine
    T E Robinson
    Department of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor 48109, USA
    Eur J Neurosci 11:1598-604. 1999
  10. ncbi Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving
    Dean F Wong
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Neuropsychopharmacology 31:2716-27. 2006

Detail Information

Publications276 found, 100 shown here

  1. ncbi Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum
    Arvind Kumar
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Neuron 48:303-14. 2005
    ..Furthermore, modulating histone deacetylase activity alters locomotor and rewarding responses to cocaine. Thus, chromatin remodeling is an important regulatory mechanism underlying cocaine-induced neural and behavioral plasticity...
  2. ncbi Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum
    David Belin
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Neuron 57:432-41. 2008
    ....
  3. ncbi Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction
    Nora D Volkow
    National Institute on Alcohol Abuse and Alcoholism, Bethesda Maryland 20892, USA
    J Neurosci 26:6583-8. 2006
    ..Because craving is a key contributor to relapse, strategies aimed at inhibiting dopamine increases from conditioned responses are likely to be therapeutically beneficial in cocaine addiction...
  4. pmc Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
    Quincey LaPlant
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 13:1137-43. 2010
    ..These data establish the importance of Dnmt3a in the NAc in regulating cellular and behavioral plasticity to emotional stimuli...
  5. pmc Cocaine regulates MEF2 to control synaptic and behavioral plasticity
    Suprabha Pulipparacharuvil
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9127, USA
    Neuron 59:621-33. 2008
    ....
  6. pmc In vivo cocaine experience generates silent synapses
    Yanhua H Huang
    Program in Neuroscience, Washington State University, Pullman, WA 99164 6520, USA
    Neuron 63:40-7. 2009
    ....
  7. ncbi Critical involvement of dopaminergic neurotransmission in impulsive decision making
    Marcel M van Gaalen
    Department of Medical Pharmacology, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, Free University Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 60:66-73. 2006
    ..Commonly prescribed for this condition, amphetamine (Adderall), reduces impulsive decision making; however, the neuropharmacologic mechanism of this effect of amphetamine is unclear...
  8. ncbi The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 163:362-80. 2002
    ..The developmental history and application of the 5-choice serial reaction time task (5CSRTT) for measuring effects of drugs and other manipulations on attentional performance (and stimulus control) in rats is reviewed...
  9. ncbi Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine
    T E Robinson
    Department of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor 48109, USA
    Eur J Neurosci 11:1598-604. 1999
    ....
  10. ncbi Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving
    Dean F Wong
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Neuropsychopharmacology 31:2716-27. 2006
    ..These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine...
  11. ncbi Sub-optimal performance in the 5-choice serial reaction time task in rats was sensitive to methylphenidate, atomoxetine and d-amphetamine, but unaffected by the COMT inhibitor tolcapone
    Neil E Paterson
    Behavioral Pharmacology, PsychoGenics, Inc, Tarrytown, NY 10591, USA
    Neurosci Res 69:41-50. 2011
    ..Finally, tolcapone had no effects on sub-optimal performance in the variable ITI 5-CSRTT. These results suggest minimal potential of tolcapone as a therapeutic agent for ADHD and implicate cortical NE, not DA, in impulsive action...
  12. pmc The binding sites for cocaine and dopamine in the dopamine transporter overlap
    Thijs Beuming
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Neurosci 11:780-9. 2008
    ..Our data demonstrate the molecular basis for the competitive inhibition of dopamine transport by cocaine...
  13. ncbi Comparison of combined bupropion and naltrexone therapy for obesity with monotherapy and placebo
    Frank L Greenway
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 94:4898-906. 2009
    ..The efficacy of current centrally acting obesity pharmacotherapies is limited by compensatory mechanisms that mitigate weight loss...
  14. pmc Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens
    Jonathan P Britt
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neuron 76:790-803. 2012
    ..Finally, direct optical activation of medium spiny neurons proved to be capable of supporting self-stimulation, demonstrating that behavioral reinforcement is an explicit consequence of strong excitatory drive to the NAc...
  15. pmc Amphetamine paradoxically augments exocytotic dopamine release and phasic dopamine signals
    D P Daberkow
    School of Biological Sciences, Cell Biology, Physiology and Development Section, Illinois State University, Normal, Illinois 61790, USA
    J Neurosci 33:452-63. 2013
    ..These findings identify upregulation of exocytotic dopamine release as a key AMPH action in behaving animals and support a unified mechanism of abused drugs to activate phasic dopamine signaling...
  16. pmc Fos after single and repeated self-administration of cocaine and saline in the rat: emphasis on the Basal forebrain and recalibration of expression
    Daniel S Zahm
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Neuropsychopharmacology 35:445-63. 2010
    ....
  17. pmc Signaling pathway adaptations and novel protein kinase A substrates related to behavioral sensitization to cocaine
    Amy C Boudreau
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
    J Neurochem 110:363-77. 2009
    ....
  18. ncbi Nucleus accumbens opioid, GABaergic, and dopaminergic modulation of palatable food motivation: contrasting effects revealed by a progressive ratio study in the rat
    Min Zhang
    Department of Psychiatry, University of Wisconsin Madison Medical School, 53715, USA
    Behav Neurosci 117:202-11. 2003
    ....
  19. ncbi Steady-dose and escalating-dose "binge" administration of cocaine alter expression of behavioral stereotypy and striatal preprodynorphin mRNA levels in rats
    Stefan D Schlussman
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Brain Res Bull 67:169-75. 2005
    ..These data suggest that the ppDyn response to cocaine in the CPu is not dose-dependent or that it has reached a maximal level at the 45 mg/kg daily dose...
  20. ncbi Modulation of D2R-NR2B interactions in response to cocaine
    Xian Yu Liu
    Department of Basic Medical Science, University of Missouri Kansas City, School of Medicine, Kansas City, Missouri 64108, USA
    Neuron 52:897-909. 2006
    ..This type of dopamine-glutamate integration at the receptor level may be responsible for synergistically inhibiting the D2R-mediated circuits in the basal ganglia and fulfilling the stimulative effect of psychostimulants...
  21. ncbi The Caenorhabditis elegans gene T23G5.5 encodes an antidepressant- and cocaine-sensitive dopamine transporter
    L D Jayanthi
    Department of Pharmacology, Nashville TN 37232 6600 and Fort Dodge Animal Health, Princeton, New Jersey 08543 0400, USA
    Mol Pharmacol 54:601-9. 1998
    ..elegans cDNA in vivo...
  22. ncbi The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats
    R E See
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 194:321-31. 2007
    ..Recent studies have implicated an important role for the dorsal striatum during craving for cocaine and in cocaine-seeking after abstinence in rats...
  23. ncbi Enhancement of locomotor activity and conditioned reward to cocaine by brain-derived neurotrophic factor
    B A Horger
    Laboratory of Molecular Psychiatry, Departments of Psychiatry, Pharmacology, and Neurobiology, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, Connecticut 06520, USA
    J Neurosci 19:4110-22. 1999
    ..These results demonstrate the profound effects of BDNF on the enhancement of both cocaine-induced locomotion and facilitation of CR and suggest a possible role for BDNF in long-term adaptations of the brain to cocaine...
  24. pmc Modulation of chromatin modification facilitates extinction of cocaine-induced conditioned place preference
    Melissa Malvaez
    Department of Neurobiology and Behavior, University of California, Irvine, Center for the Neurobiology of Learning and Memory, Irvine, California 92697 3800, USA
    Biol Psychiatry 67:36-43. 2010
    ..In this study, we examined the ability of histone deacetylase (HDAC) inhibitors to facilitate extinction and attenuate reinstatement of cocaine-induced conditioned place preference (CPP)...
  25. ncbi Real-time decoding of dopamine concentration changes in the caudate-putamen during tonic and phasic firing
    B Jill Venton
    Department of Chemistry and Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599 3290, USA
    J Neurochem 87:1284-95. 2003
    ..These simulations show that synchronous phasic firing can produce spatially and temporally heterogeneous concentration profiles whereas asynchronous tonic firing elicits uniform, steady-state dopamine concentrations...
  26. pmc LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake
    Zheng Zhou
    Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Science 317:1390-3. 2007
    ..Mutagenesis experiments on human SERT and DAT indicate that both the desipramine-binding site and its inhibition mechanism are probably conserved in the human neurotransmitter transporters...
  27. ncbi Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys
    S R Letchworth
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    J Neurosci 21:2799-807. 2001
    ....
  28. pmc Preferential enhancement of dopamine transmission within the nucleus accumbens shell by cocaine is attributable to a direct increase in phasic dopamine release events
    Brandon J Aragona
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3290, USA
    J Neurosci 28:8821-31. 2008
    ..Together, these results demonstrate that cocaine administration results in a temporally and regionally specific increase in phasic dopamine release that is significantly regulated by dopamine autoreceptors...
  29. pmc Differential effects of cocaine on dopamine neuron firing in awake and anesthetized rats
    Stanislav Koulchitsky
    Laboratory of Pharmacology and GIGA Neurosciences, University of Liege, Sart Tilman Liège, Belgium
    Neuropsychopharmacology 37:1559-71. 2012
    ..Our observations also show that electrophysiological recordings in awake animals can uncover drug effects, which are masked by general anesthesia...
  30. ncbi Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 29:1190-202. 2004
    ..Additional research is warranted to unravel potential neurobiological traits that might confer vulnerability to relapse in detoxified CCD subjects...
  31. pmc Cocaine-induced metaplasticity in the nucleus accumbens: silent synapse and beyond
    Brian R Lee
    Program in Neuroscience, Washington State University, Wegner 205, PO Box 646520, Pullman, WA 99164 6520, USA
    Neuropharmacology 61:1060-9. 2011
    ..Taken together, metaplasticity ultimately serves as a key step in mediating cascades of addiction-related plastic alterations...
  32. ncbi Cocaine administered into the medial prefrontal cortex reinstates cocaine-seeking behavior by increasing AMPA receptor-mediated glutamate transmission in the nucleus accumbens
    W K Park
    Laboratory of Neuropsychopharmacology, Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci 22:2916-25. 2002
    ..Moreover, the present results demonstrate that AMPA and NMDA receptors in the nucleus accumbens have opposing roles in the reinstatement of cocaine-seeking behavior...
  33. pmc Distinct contributions of dopamine in the dorsolateral striatum and nucleus accumbens shell to the reinforcing properties of cocaine
    Maartje M J Veeneman
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuropsychopharmacology 37:487-98. 2012
    ..We suggest that the DLS and the NAcc shell mediate somewhat distinct facets of the reinforcing properties of cocaine, related to its rewarding and motivational aspects, respectively...
  34. pmc ∆FosB differentially modulates nucleus accumbens direct and indirect pathway function
    Brad A Grueter
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94305, USA
    Proc Natl Acad Sci U S A 110:1923-8. 2013
    ..These results reveal that ∆FosB in NAc differentially modulates synaptic properties and reward-related behaviors in a cell type- and subregion-specific fashion...
  35. pmc Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats
    Q David Walker
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Pharmacol Exp Ther 335:124-32. 2010
    ..research from our laboratory suggests that adolescent dopamine systems may be most affected by selective dopamine uptake inhibitors. We investigated age-related behavioral responses to acute administration of several dopamine uptake ..
  36. pmc Synapsins differentially control dopamine and serotonin release
    Brian M Kile
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci 30:9762-70. 2010
    ..These results provide further support for the concept that synapsin function in presynaptic terminals varies according to the neurotransmitter being released...
  37. ncbi Norepinephrine in the prefrontal cortex is critical for amphetamine-induced reward and mesoaccumbens dopamine release
    Rossella Ventura
    Dipartimento di Psicologia, Universita La Sapienza, 00185 Rome, Italy
    J Neurosci 23:1879-85. 2003
    ..These results indicate that noradrenergic prefrontal transmission, by allowing increased dopamine release in the nucleus accumbens induced by amphetamine, is a critical factor for the rewarding-reinforcing effects of this drug...
  38. pmc Different effects of selective dopamine uptake inhibitors, GBR 12909 and WIN 35428, on HIV-1 Tat toxicity in rat fetal midbrain neurons
    Michael Y Aksenov
    Program in Behavioral Neuroscience, University of South Carolina, USA
    Neurotoxicology 29:971-7. 2008
    ..Our results also demonstrate that inhibitors of DA uptake, which can bind to different domains of DAT, differ in their ability to mimic synergistic toxicity of cocaine and HIV-1 Tat in the midbrain cell culture...
  39. pmc Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive task
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Proc Natl Acad Sci U S A 107:16667-72. 2010
    ..neutral) cue-reactivity condition in all subjects. The clinical application of such MPH-induced brain-behavior enhancements remains to be tested...
  40. ncbi Striatal dopaminergic abnormalities in human cocaine users
    K Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor VA Medical Center 48105, USA
    Am J Psychiatry 156:238-45. 1999
    ..Previous inconsistencies in results were perhaps related to selective radioligand affinity changes or a coexisting loss of dopamine neurons...
  41. ncbi A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats
    William J Berglind
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Eur J Neurosci 26:757-66. 2007
    ....
  42. pmc Augmented cocaine seeking in response to stress or CRF delivered into the ventral tegmental area following long-access self-administration is mediated by CRF receptor type 1 but not CRF receptor type 2
    Jordan M Blacktop
    Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin 53201, USA
    J Neurosci 31:11396-403. 2011
    ..These findings reveal that excessive cocaine use increases susceptibility to stressor-induced relapse in part by augmenting CRF-R1-dependent regulation of addiction-related neurocircuitry in the VTA...
  43. ncbi Adolescents differ from adults in cocaine conditioned place preference and cocaine-induced dopamine in the nucleus accumbens septi
    Kimberly A Badanich
    Department of Psychology, Cognitive and Neural Sciences, University of South Florida 4202 E Fowler Avenue Tampa, FL 33620, USA
    Eur J Pharmacol 550:95-106. 2006
    ..Together these findings suggest ontogenetic differences in extracellular dopamine and dopamine reuptake and that these differences may provide an explanation for adolescent vulnerability to addiction...
  44. pmc Attenuation of cue-induced cigarette craving and anterior cingulate cortex activation in bupropion-treated smokers: a preliminary study
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, David Geffen Schol of Medicine, University of Californai at Los Angeles, and Positron Emission Tomography Center, Greater Los Angeles Veterans Affairs Healthcare System, USA
    Psychiatry Res 130:269-81. 2004
    ..These results are consistent with the known effects of bupropion HCl, including its enhancement of catecholaminergic neurotransmission...
  45. pmc Effects of acute cocaine or dopamine receptor agonists on AMPA receptor distribution in the rat nucleus accumbens
    Carrie R Ferrario
    Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064 3095, USA
    Synapse 65:54-63. 2011
    ..They further suggest that cocaine exerts these effects by influencing neuronal circuits rather than simply stimulating NAc DA transmission...
  46. ncbi Prolonged withdrawal from repeated noncontingent cocaine exposure increases NMDA receptor expression and ERK activity in the nucleus accumbens
    Johanna Schumann
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Neurosci 29:6955-63. 2009
    ..Enhanced ERK activity drives the increased expression of the GluR1 subunits, which increases the excitability of NAc neurons after prolonged withdrawal from cocaine and results in enduring expression of psychomotor sensitization...
  47. pmc Gene profiling the response to repeated cocaine self-administration in dorsal striatum: a focus on circadian genes
    Wendy J Lynch
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, USA
    Brain Res 1213:166-77. 2008
    ..These data strongly suggest involvement of circadian-associated genes in the brain's response to cocaine and may contribute to an understanding of addictive behavior including disruptions in sleep and circadian rhythmicity...
  48. ncbi Sustained-release bupropion for smoking cessation in African Americans: a randomized controlled trial
    Jasjit S Ahluwalia
    Department of Preventive Medicine and Public Health, University of Kansas School of Medicine and Kansas Cancer Institute, Kansas City, KS 66160 7313, USA
    JAMA 288:468-74. 2002
    ..Few clinical trials for smoking cessation in African Americans have been conducted, despite a different profile of both smoking and quitting patterns...
  49. pmc The feasibility of smoking reduction: an update
    John R Hughes
    Department of Psychiatry, Psychology and Family Practice, University of Vermont, Burlington, VT 05401, USA
    Addiction 100:1074-89. 2005
    ....
  50. ncbi Cortical mechanisms of cocaine sensitization
    Jeffery D Steketee
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Crit Rev Neurobiol 17:69-86. 2005
    ..A model will be presented that may serve to direct future studies on the involvement of the mPFC in the development of cocaine sensitization, which ultimately could lead to development of pharmacotherapies for cocaine addiction...
  51. ncbi Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5
    S D Norrholm
    Program in Neuroscience, Department of Psychology, The Florida State University, 251 Biomedical Research Facility, Tallahassee FL 32306, USA
    Neuroscience 116:19-22. 2003
    ..These data indicate that cyclin-dependent kinase-5 is involved in regulation of, as well as cocaine-induced changes in, dendritic spine density...
  52. pmc Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward
    Danielle L Graham
    CNS Pharmacology, Merck Research Labs, Boston Massachusetts, USA
    Biol Psychiatry 65:696-701. 2009
    ..Previous studies found that brain-derived neurotrophic factor (BDNF) derived from nucleus accumbens (NAc) neurons can mediate persistent behavioral changes that contribute to cocaine addiction...
  53. ncbi Dopaminergic mechanisms mediating the incentive to seek cocaine and heroin following long-term withdrawal of IV drug self-administration
    T J de Vries
    Research Institute Neurosciences Vrije Universiteit, Department of Pharmacology, Medical Faculty, Free University, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 143:254-60. 1999
    ..The neurobiological mechanisms underlying the persistence of drug craving in detoxified addicts are still poorly understood...
  54. ncbi Behavioral sensitization to cocaine is associated with increased AMPA receptor surface expression in the nucleus accumbens
    Amy C Boudreau
    Department of Neuroscience, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
    J Neurosci 25:9144-51. 2005
    ..We propose that drug-seeking responses are more effectively triggered in cocaine-sensitized rats because of increased cell surface expression of AMPA receptors...
  55. ncbi Impact of self-administered cocaine and cocaine cues on extracellular dopamine in mesolimbic and sensorimotor striatum in rhesus monkeys
    C W Bradberry
    Departments of Psychiatry and Laboratory Medicine, Yale University School of Medicine and the West Haven Veteran s Administration Hospital, West Haven, Connecticut 06516, USA
    J Neurosci 20:3874-83. 2000
    ....
  56. ncbi Voltammetric study of extracellular dopamine near microdialysis probes acutely implanted in the striatum of the anesthetized rat
    Laura M Borland
    Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA 15260, USA
    J Neurosci Methods 146:149-58. 2005
    ..The findings of this study show that a gradient of dopamine release and uptake activity extends at least 220 microm from microdialysis probes implanted acutely in the striatum of the anesthetized rat...
  57. ncbi Are there gender differences in smoking cessation, with and without bupropion? Pooled- and meta-analyses of clinical trials of Bupropion SR
    Deborah Scharf
    Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Addiction 99:1462-9. 2004
    ..We test whether women and men have comparable success rates quitting smoking regardless of treatment, whether Bupropion SR is effective for women, and whether Bupropion SR efficacy differs for men and women...
  58. ncbi Cell type-specific alterations in the nucleus accumbens by repeated exposures to cocaine
    Juhyun Kim
    Department of Life Science, Pohang University of Science and Technology, Pohang, Gyungbuk, Republic of Korea
    Biol Psychiatry 69:1026-34. 2011
    ..Although NAc MSNs are known to undergo extensive alterations in their characteristics upon exposure to drugs of abuse, the functional and structural changes specific to each type of MSN have yet to be fully resolved...
  59. ncbi Acute cocaine exposure alters spine density and long-term potentiation in the ventral tegmental area
    Federica Sarti
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, San Francisco, CA 94608, USA
    Eur J Neurosci 26:749-56. 2007
    ..Taken together, our data provide evidence that increased spine density and synaptic plasticity are coexpressed within the same VTA neuronal population and that only type I neurons are structurally and synaptically modified by cocaine...
  60. ncbi Effects of acute "binge" cocaine on preprodynorphin, preproenkephalin, proopiomelanocortin, and corticotropin-releasing hormone receptor mRNA levels in the striatum and hypothalamic-pituitary-adrenal axis of mu-opioid receptor knockout mice
    Yan Zhou
    Laboratory of the Biology of Addictive Diseases, Box 171, The Rockefeller University, New York, NY 10021, USA
    Synapse 45:220-9. 2002
    ..MOR -/- mice are useful models for studying cocaine effects on ppEnk gene expression that could aid interpretation of the similar postmortem phenomena found in human cocaine addicts...
  61. pmc Afferent-specific AMPA receptor subunit composition and regulation of synaptic plasticity in midbrain dopamine neurons by abused drugs
    Cameron H Good
    Electrophysiology Research Section, Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 30:7900-9. 2010
    ..This suggests that different abused drugs may exert influence over distinct sets of glutamatergic afferents to VTA DA neurons which may be associated with different reinforcing or addictive properties of these drugs...
  62. pmc Sleep deprivation decreases binding of [11C]raclopride to dopamine D2/D3 receptors in the human brain
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 28:8454-61. 2008
    ....
  63. pmc Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization
    Eisuke Koya
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    Nat Neurosci 12:1069-73. 2009
    ..This method provides a new tool for studying the causal roles of selectively activated neurons in behavioral effects of drugs and drug cues and in other learned behaviors...
  64. ncbi Consequences of paternal cocaine exposure in mice
    Fang He
    Department of Biomedical Sciences and Program of Neuroscience, University of Maryland, Baltimore, 5 A 12, HHH, 666 W Baltimore St, Baltimore, MD 21201, USA
    Neurotoxicol Teratol 28:198-209. 2006
    ....
  65. pmc Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice
    Morgane Thomsen
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurosci 29:1087-92. 2009
    ..These findings support the notion that the DAT, but not the SERT, is critical in mediating the reinforcing effects of cocaine...
  66. ncbi Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines
    Jose A Morón
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 22:389-95. 2002
    ..These data underscore the fact that which transporter clears dopamine from a given region depends on both the affinities and the local densities of the transporters...
  67. ncbi The induction of behavioural sensitization is associated with cocaine-induced structural plasticity in the core (but not shell) of the nucleus accumbens
    Yilin Li
    Department of Psychology Biopsychology and Neuroscience Program, The University of Michigan, East Hall, 525 East University, Ann Arbor, MI 48109 1109, USA
    Eur J Neurosci 20:1647-54. 2004
    ....
  68. pmc Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca²⁺-permeable AMPA receptors during the incubation of cocaine craving
    Carrie R Ferrario
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    Neuropharmacology 61:1141-51. 2011
    ..Overall, AMPAR plasticity in the incubation model shares some features with better described forms of synaptic plasticity, although the timing of the phenomenon and the persistence of related neuroadaptations are significantly different...
  69. ncbi Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial
    David Gonzales
    Smoking Cessation Center, Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    JAMA 296:47-55. 2006
    ..The alpha4beta2 nicotinic acetylcholine receptors (nAChRs) are linked to the reinforcing effects of nicotine and maintaining smoking behavior. Varenicline, a novel alpha4beta2 nAChR partial agonist, may be beneficial for smoking cessation...
  70. pmc Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins
    William Renthal
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Neuron 62:335-48. 2009
    ....
  71. ncbi National Association of Medical Examiners position paper on the certification of cocaine-related deaths
    Boyd G Stephens
    Office of the Chief Medical Examiner, City and County of San Francisco, San Francisco, California 94103 4603, USA
    Am J Forensic Med Pathol 25:11-3. 2004
    ..These guidelines are intended for use by practicing medical examiners and physicians who certify drug deaths, as well as providing education tools for students...
  72. ncbi An open-label study of naltrexone and bupropion combination therapy for smoking cessation in overweight and obese subjects
    Charles S Wilcox
    Pharmacology Research Institute, Los Alamitos, CA, USA
    Addict Behav 35:229-34. 2010
    ..In overweight or obese smokers, naltrexone/bupropion combination therapy with behavioral counseling was associated with decreased nicotine use, limited nicotine withdrawal symptoms, and no significant weight gain...
  73. pmc Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors
    Frederick A Schroeder
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA
    Neuropsychopharmacology 33:2981-92. 2008
    ....
  74. ncbi Interleukin-2 potentiates novelty- and GBR 12909-induced exploratory activity
    S S Zalcman
    Department of Psychiatry and Rutgers UMDNJ Integrative Neuroscience Program, UMD New Jersey Medical School, Medical Science Building, E 503, 185 S Orange Ave, Newark, NJ 07103 2714, USA
    Brain Res 899:1-9. 2001
    ..847 (1999) 276-283), it is suggested that cytokines can influence the development of behavioral abnormalities that are characteristic of aberrant mesolimbic dopamine activity via sensitization-like processes...
  75. ncbi Adrenalectomy prevents behavioural sensitisation of mice to cocaine in a genotype-dependent manner
    Inge E M de Jong
    Leiden Amsterdam Center for Drug Research and Leiden University Medical Center, Division of Medical Pharmacology, Gorlaeus Laboratories, Einsteinweg 55, P O Box 9502, 2300 RA Leiden, The Netherlands
    Behav Brain Res 177:329-39. 2007
    ..The present results demonstrate that adrenal stress hormones facilitate behavioural sensitisation to cocaine in a genotype-dependent manner and suggest that glucocorticoids contribute to strain differences in psychostimulant sensitivity...
  76. pmc Group I mGluR activation reverses cocaine-induced accumulation of calcium-permeable AMPA receptors in nucleus accumbens synapses via a protein kinase C-dependent mechanism
    James E McCutcheon
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci 31:14536-41. 2011
    ..Furthermore, they suggest that activation of mGluR1 may represent a potential strategy for reducing cue-induced cocaine craving in abstinent cocaine addicts...
  77. ncbi Evaluation of the safety of bupropion (Zyban) for smoking cessation from experience gained in general practice use in England in 2000
    Andrew Boshier
    Drug Safety Research Unit, Southampton, UK
    Eur J Clin Pharmacol 59:767-73. 2003
    ..In smoking cessation trials, it has been associated with minimal side effects. A range of suspected adverse drug reactions (ADRs) were reported via the spontaneous reporting system following its use in smoking cessation...
  78. pmc Chronic treatment with extended release methylphenidate does not alter dopamine systems or increase vulnerability for cocaine self-administration: a study in nonhuman primates
    Kathryn E Gill
    Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC, USA
    Neuropsychopharmacology 37:2555-65. 2012
    ..Furthermore, this treatment regimen and subsequent drug washout did not have an impact on vulnerability to cocaine abuse...
  79. ncbi Self-efficacy and motivation to quit during participation in a smoking cessation program
    Thuy Boardman
    Department of Preventive Medicine and Public Health, University of Kansas Medical Center, Kansas City, KS, USA
    Int J Behav Med 12:266-72. 2005
    ..Results suggest that unsuccessful participation in a smoking cessation program does not meaningfully reduce smokers' self-efficacy and motivation to quit...
  80. ncbi Repeated cocaine treatment decreases whole-cell calcium current in rat nucleus accumbens neurons
    Xu Feng Zhang
    Department of Cellular and Molecular Pharmacology, Finch University of Health Sciences, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60048, USA
    J Pharmacol Exp Ther 301:1119-25. 2002
    ....
  81. ncbi Differential time-course profiles of dopamine release and uptake changes induced by three dopamine uptake inhibitors
    T H Lee
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    Synapse 41:301-10. 2001
    ..The time-course mismatch between uptake inhibition and DA release potentiation as well as release rebound during washout suggests that altered dopamine release might play a role in behavioral effects of cocaine...
  82. ncbi Individual differences in cocaine-induced locomotor sensitization in low and high cocaine locomotor-responding rats are associated with differential inhibition of dopamine clearance in nucleus accumbens
    Jilla Sabeti
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Pharmacol Exp Ther 305:180-90. 2003
    ..Our results suggest that increased DAT inhibition by cocaine is associated with locomotor sensitization and that DAT serves as a common substrate for mediating both the initial and sensitized locomotor responsiveness to cocaine...
  83. pmc When administered into the nucleus accumbens core or shell, the NMDA receptor antagonist AP-5 reinstates cocaine-seeking behavior in the rat
    Katie R Famous
    Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA
    Neurosci Lett 420:169-73. 2007
    ..This study provides evidence that pharmacological antagonism of NMDA receptors in the nucleus accumbens core or shell promotes the reinstatement of cocaine seeking...
  84. ncbi Methylphenidate administration alters vesicular monoamine transporter-2 function in cytoplasmic and membrane-associated vesicles
    Trent J Volz
    Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    J Pharmacol Exp Ther 323:738-45. 2007
    ....
  85. ncbi Effects of dopamine D(1-like) and D(2-like) agonists on cocaine self-administration in rhesus monkeys: rapid assessment of cocaine dose-effect functions
    S B Caine
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 148:41-51. 2000
    ..Although it is generally believed that both D(1-like )and D(2-like )receptor mechanisms may be involved, recent studies suggest that D(1-like )and D(2-like )agonists have differing profiles of cocaine-related actions...
  86. ncbi Repeated cocaine administration increases GABA(B(1)) subunit mRNA in rat brain
    Mika Yamaguchi
    Department of Psychiatry, Institute of Clinical Medicine, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Synapse 43:175-80. 2002
    ..The observed changes in the mRNA level after the repeated cocaine may imply changes of GABA(B(1)) subunit in molecular mechanisms which underlie development of behavioral sensitization...
  87. ncbi Repeated cocaine administration decreases calcineurin (PP2B) but enhances DARPP-32 modulation of sodium currents in rat nucleus accumbens neurons
    Xiu Ti Hu
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
    Neuropsychopharmacology 30:916-26. 2005
    ..They also suggest that chronic COC-induced I(Na) reduction may be attributed to a reduction in Ca(2+) signaling, which disrupts the physiological balance of phosphorylation and dephosphorylation of Na(+) channels...
  88. ncbi Cocaine induction of dopamine transporter trafficking to the plasma membrane
    Karley Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA
    Mol Pharmacol 61:436-45. 2002
    ..The present model system may further our understanding of regulatory alterations in DAT radioligand binding and function caused by cocaine exposure...
  89. ncbi Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission
    Q Wu
    Cellular and Integrative Physiology Section, Department of Biological Sciences, Illinois State University, Normal, Illinois 61790-4120, USA
    J Neurosci 21:6338-47. 2001
    ..The mechanism proposed for the preferential actions of cocaine may also mediate the differential effects of psychostimulant in extrastriatal regions and other uptake inhibitors in the striatum...
  90. ncbi Cocaine regulates ezrin-radixin-moesin proteins and RhoA signaling in the nucleus accumbens
    W Y Kim
    Department of Physiology, Brain Korea 21 Project for Medical Science, Brain Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodaemungu, Seoul 120 752, South Korea
    Neuroscience 163:501-5. 2009
    ....
  91. ncbi Differential effects of morphine- and cocaine-induced nNOS immunoreactivity in the dentate gyrus of hippocampus of mice lacking mu-opioid receptors
    Ji Hoon Yoo
    Department of Pharmacology, College of Pharmacy, Sungkyunkwan University, 300 Cheoncheon dong, Jangan gu, Suwon 440 746, Republic of Korea
    Neurosci Lett 395:98-102. 2006
    ..These results suggest that morphine and cocaine sensitization is differentially regulated by the mu-opioid receptors in MOR(-/-) mice via the nNOS systems in the DG...
  92. pmc Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys
    Emanuele Seu
    Department of Psychology, University of California Los Angeles, P O Box 951563, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 202:505-19. 2009
    ....
  93. pmc Low and high locomotor responsiveness to cocaine predicts intravenous cocaine conditioned place preference in male Sprague-Dawley rats
    Richard M Allen
    Department of Psychology, University of Colorado at Denver and Health Sciences Center, CB 173, PO Box 173364, Denver, CO 80217, USA
    Pharmacol Biochem Behav 86:37-44. 2007
    ....
  94. ncbi Progesterone attenuates cocaine-induced responses
    Vanya Quinones-Jenab
    Department of Psychology, Hunter College and Biopsychology and Behavioral Neuroscience PhD Subprogram, The Graduate Center, The City University of New York, 695 Park Ave, New York, NY 10065, USA
    Horm Behav 58:22-32. 2010
    ..Constantly changing progesterone serum levels in female humans and rats affect the female's reinforcement responses to cocaine and may in part contribute to the known sex differences in cocaine responses...
  95. ncbi Effects of high-dose methadone maintenance on cocaine place conditioning, cocaine self-administration, and mu-opioid receptor mRNA expression in the rat brain
    Francesco Leri
    Department of Psychology, University of Guelph, Guelph, ON, Canada
    Neuropsychopharmacology 31:1462-74. 2006
    ....
  96. ncbi Prenatal cocaine exposure alters potassium-evoked dopamine release dynamics in rat striatum
    M F Salvatore
    Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Center for Sensor Technology, Davis Mills Building, 800 Rose Street, Lexington, KY 40536, USA
    Neuroscience 123:481-90. 2004
    ..These molecular events may be associated with established cognitive deficits and perhaps the trends seen in altered motor behavior...
  97. ncbi Effect of chronic "binge cocaine" on basal levels and cocaine-induced increases of dopamine in the caudate putamen and nucleus accumbens of C57BL/6J and 129/J mice
    Yong Zhang
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Synapse 50:191-9. 2003
    ....
  98. ncbi Individual differences in cocaine-induced locomotor activity in rats: behavioral characteristics, cocaine pharmacokinetics, and the dopamine transporter
    Joshua M Gulley
    Department of Pharmacology and Neuroscience Program, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Neuropsychopharmacology 28:2089-101. 2003
    ..Our results argue against several likely explanations for individual differences in cocaine-induced behavior and highlight the influence of a single cocaine exposure on subsequent behavioral responses to the drug...
  99. ncbi Cocaine induces a dose-dependent alteration in the expression of immediate early genes c-fos and SP-1 and in nuclear factor NF-kappabeta in PC12 cells
    Syed Z Imam
    Division of Neurotoxicology, US FDA NCTR, Jefferson, Arkansas 72079, USA
    Ann N Y Acad Sci 993:362; discussion 387-93. 2003
  100. ncbi Neuronal nitric oxide synthase inhibition decreases cocaine self-administration behavior in rats
    Stephanie L Collins
    Laboratory of Behavioral Neuroscience, Department of Psychology, 64 Cummington Street, Boston University, Boston, MA 02215, USA
    Psychopharmacology (Berl) 159:361-9. 2002
    ..However, previous studies have largely used mixed-action NOS inhibitors and have not examined the effects of a neuronal NOS inhibitor on cocaine self-administration...
  101. pmc Low and high cocaine locomotor responding male Sprague-Dawley rats differ in rapid cocaine-induced regulation of striatal dopamine transporter function
    Bruce H Mandt
    University of Colorado Denver, Department of Pharmacology, Aurora, CO 80217, USA
    Neuropharmacology 58:605-12. 2010
    ..These findings suggest that, compared to LCRs, HCRs have an enhanced ability to rapidly up-regulate DAT function in response to acute cocaine, which may contribute to their more "normal" cocaine-induced locomotor activation...

Research Grants65

  1. Synthesis of Selective Dopamine Uptake Inhibitors
    Shaine Cararas; Fiscal Year: 2006
    ..These studies are designed to explore further the SAR of this novel class of dopamine uptake inhibitors with the aim of developing more potent and more selective analogues...
  2. POLYDRUG ABUSE IN WOMEN
    NANCY MELLO; Fiscal Year: 2000
    ....
  3. Cocaine behavior: Regulation by k-opioids and serotonin
    Sari Izenwasser; Fiscal Year: 2009
    ..In addition, the upregulation of kappa-opioid receptors is not produced by selective dopamine uptake inhibitors. Together, these findings suggest that the bi-directional interactions between cocaine and kappa-opioid ..
  4. Cocaine and Polydrug Abuse: New Medication Strategies
    NANCY MELLO; Fiscal Year: 2006
    ..Advances in understanding the neurobiological determinants of the abuse-related effects of drugs should facilitate the development of more effective treatment medications. ..
  5. GBR DOPAMINE TRANSPORTER BINDING:PHARMACOPHORE MODELING
    Kathleen Gilbert; Fiscal Year: 2004
    ..The GBR series of dialkyl piperazines have been identified as selective dopamine uptake inhibitors that could be used to treat cocaine addiction...
  6. MEDICINAL CHEMISTRY SYNTHESIS OF POTENTIAL TREATMENT
    ANANTHAN SUBRAMANIAM; Fiscal Year: 2000
    ..The project shall involve the synthesis of any of the following: dopamine uptake inhibitors with a slower rate of onset than cocaine; compound which affect dopaminergic systems through the ..
  7. INTEROCEPTIVE DRUG CUE CONDITIONING OF COCAINE EFFECTS
    Robert Carey; Fiscal Year: 2002
    ..This research is important for the identification of the ways interoceptive drug cues can activate or inactivate cocaine conditioned stimuli. ..
  8. Reconsolidation and extinction processes in the treatment of drug addiction
    Yossef Itzhak; Fiscal Year: 2010
    ..abstract_text> ..
  9. Adolescent Exposure to Psychostimulants: Role of nNOS
    Yossef Itzhak; Fiscal Year: 2008
    ..Results of these studies would provide new information on mechanisms that underlie the development of hypersensitivity to these drugs from adolescence through adulthood. ..
  10. Substituted Amphetamines: NO-Dependent Mechanisms
    Yossef Itzhak; Fiscal Year: 2005
    ....
  11. Neuroscience at the Boundaries of Neurology and Psychiatry
    Neal Swerdlow; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  12. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal R Swerdlow; Fiscal Year: 2010
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  13. Neural basis of heritable DA-mediated gating deficits
    Neal R Swerdlow; Fiscal Year: 2010
    ....
  14. A Simple Measure for Studying Sensory Gating Deficits
    Neal Swerdlow; Fiscal Year: 2007
    ..abstract_text> ..
  15. NEURAL CIRCUITRY OF SENSORIMOTOR GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2006
    ....
  16. Heavy Metal and Drug Self-Administration: Mechanisms
    PAUL JEFFERSON WELLMAN; Fiscal Year: 2010
    ..e., lead contamination and cocaine use. Based on the available literature, there is reason to believe that environmental pollutants may increase vulnerability to drug addiction. ..
  17. Psychostimulants and Alpha-1 Adrenoceptor Subtypes
    Paul Wellman; Fiscal Year: 2006
    ..These studies will advance our understanding of the behavioral functions of brain a l-AR subtypes and may lead to the identification of new drugs that inhibit eating without activating brain reinforcement systems. ..
  18. DOPAMINERGIC MECHANISMS IN STIMULANT SELF-ADMINISTRATION
    William Woolverton; Fiscal Year: 2005
    ..abstract_text> ..
  19. BEHAVIORAL PHARMACOLOGY OF DRUG SELF-ADMINISTRATION
    William Woolverton; Fiscal Year: 2006
    ..abstract_text> ..
  20. Primate Model of the Transition to Cocaine Addiction
    JAMES ROWLETT; Fiscal Year: 2005
    ..The results will provide needed information for developing a nonhuman primate model that can serve as a quantitative platform for future research on neuroadaptations underlying the transition to persistent cocaine self-administration. ..
  21. Self-administration of drug combinations: Polydrug abuse
    William L Woolverton; Fiscal Year: 2010
    ..Moreover, our model should provide key information for the development of improved strategies for the treatment of polydrag abuse. ..
  22. NOVEL PHARMACOTHERAPIES FOR COCAINE DEPENDENCE
    Frank Carroll; Fiscal Year: 2001
    ..An ideal candidate compound would not only have efficacy in the preclinical models but would be safe, orally active, and potent, would not show tolerance or sensitization, and if abusable, would be less so than cocaine. ..
  23. Design and Development of Pharmacotherapies for Treating Stimulant Abuse
    Frank Ivy Carroll; Fiscal Year: 2010
    ..3) To continue on a limited basis our development of selected 3-phenyltropane analogs as second-generation pharmacotherapies to treat cocaine addiction. ..
  24. COCAINE: A STUDY OF THE BIOCHEMICAL MECHANISM OF ACTION
    Frank Carroll; Fiscal Year: 2007
    ..abstract_text> ..
  25. Nonhuman Primate Model of Benzodiazepine Relapse
    JAMES ROWLETT; Fiscal Year: 2002
    ....
  26. DETERMINANTS OF DRUG CHOICE
    William Woolverton; Fiscal Year: 2004
    ..Further, an understanding of the variables that control the choice to self-administer a drug is crucial to the refinement of drug abuse treatment. ..
  27. NOVEL PHARMACOTHERAPY FOR TREATMENT OF COCAINE ADDICTION
    Frank Carroll; Fiscal Year: 2008
    ..abstract_text> ..
  28. Medication Development for Marijuana Relapse
    Margaret Haney; Fiscal Year: 2008
    ..abstract_text> ..
  29. Measuring Striatal Neurotransmission in Behaving Rats after Experimental TBI
    Amy Wagner; Fiscal Year: 2008
    ..The overarching goal is to gain insight into potential mechanisms of action and efficacy of these interventions on cognition and recovery for the clinical population with TBI. [unreadable] [unreadable] [unreadable]..
  30. Glutamate Signaling and Drug Abuse
    MOHAMMADHOSSEIN GHASEMZADEH; Fiscal Year: 2007
    ....
  31. ENVIRONMENTAL INFLUENCES ON COCAINE SELF-ADMINISTRATION
    NICHOLAS GOEDERS; Fiscal Year: 2007
    ..The experiments described in this revised application were designed with these stipulations in mind, taking into consideration the recommendations of the reviewers of the previous submission. ..
  32. Treatment of Nicotine Dependence in Health Care Setting
    Gary Swan; Fiscal Year: 2009
    ....
  33. Glycine Transport Inhibition for Nicotine Dependence in Schizophrenia
    A Evins; Fiscal Year: 2009
    ....
  34. Pharmacogenetic Investigation of Naltrexone
    Caryn Lerman; Fiscal Year: 2007
    ..The long-term objective of this research is to discover and develop new pharmacogenetic treatment models that can be readily translated to the clinical setting to individualize pharmacotherapy and maximize effectiveness. ..
  35. Smoking Cessation and Smoking Relapse Prevention in Patients with Schizophrenia
    A Eden Evins; Fiscal Year: 2010
    ..Participants will then discontinue study medications and enter a 3-month follow up. The primary outcome measure will be 7-day point prevalence abstinence rate at 12 months in the intervention vs. placebo groups. ..
  36. Biometric and Measured Genetic Research on Smoking
    Gary Swan; Fiscal Year: 2007
    ..Such knowledge will confer new insights about the etiology and progression of smoking and should improve the current understanding of smoking, which is still largely descriptive. ..
  37. Discovery of Novel Pharmacotherapies: Cocaine Dependence
    PETER MELTZER; Fiscal Year: 2008
    ..vi) analogues of pyrovalerone. ..
  38. Amygdala D1 Receptor Modulation of Cocaine-Mediated Memories
    RICK BERNARDI; Fiscal Year: 2008
    ..The current proposal focuses on a specific brain area known as the amygdala, and its potential role in memory processes that mediate the effects of cocaine-related stimuli and perpetuate addiction. [unreadable] [unreadable] [unreadable]..
  39. NICOTINE AND SMOKING CESSATION IN SCHIZOPHRENIA
    A Evins; Fiscal Year: 2005
    ....
  40. Psychobiological /Genetic Determinants-Smoking Cessation
    Sean David; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  41. Gordon Conference on Catecholamines (2003)
    Terry Robinson; Fiscal Year: 2003
    ....
  42. Primary Care Genetics Cancer Prevention Conference
    Sean David; Fiscal Year: 2003
    ..abstract_text> ..
  43. COCAINE SELF ADMINISTRATION IN DOPAMINE KNOCKOUT MICE
    SIMON CAINE; Fiscal Year: 2003
    ..abstract_text> ..
  44. Combined Voltammetry/Electrophysiology in Behaving Rats
    REGINA CARELLI; Fiscal Year: 2002
    ..As such, we will be able to directly examine the contribution of DA in mediating underlying cellular mechanisms in the Acb that are involved in encoding information related to cocaine reinforcement. ..
  45. Neurochemistry of Cocaine Reinforcement
    NICHOLAS GOEDERS; Fiscal Year: 2002
    ..These results will also provide evidence of the role that is played by steroid hormones in shaping the functional activity of the brain. ..
  46. THC AND MARIJUANA--EFFECTS IN INDIVIDUALS WITH HIV/AIDS
    Margaret Haney; Fiscal Year: 2002
    ....
  47. NEURAL BASIS OF BEHAVIORAL SENSITIZATION
    Terry Robinson; Fiscal Year: 2001
    ..In summary, these studies should provide new insights into how drug-environment interactions can so dramatically alter drug effects, including liability to forms of drug-induced plasticity that may contribute to addiction. ..
  48. DETERMINANTS OF DRUG EFFECTS ON DRUG MAINTAINED BEHAVIOR
    NICHOLAS GOEDERS; Fiscal Year: 2001
    ..abstract_text> ..
  49. CVD RISK FACTORS AND BRAIN MORPHOLOGY IN NHLBI TWINS
    Gary Swan; Fiscal Year: 2001
    ....
  50. BIOBEHAVIORAL LUNG CANCER PREVENTION PROGRAM
    Caryn Lerman; Fiscal Year: 2004
    ..The long-term objective is to provide information necessary to match smoking cessation treatments to individuals, based on their genetic predispositions. ..
  51. Role for the HPA Axis in Methamphetamine Reinforcement
    NICHOLAS GOEDERS; Fiscal Year: 2005
    ..abstract_text> ..
  52. Behavioral correlates of fMRI response in cocaine users
    Rita Goldstein; Fiscal Year: 2006
    ..abstract_text> ..
  53. Neuroadaptations underlying the transition to addiction.
    Osnat Ben Shahar; Fiscal Year: 2006
    ..Together, these experiments will illuminate some of the changes in dopaminergic function that underlie the transition to compulsive drug-use. ..
  54. Dopaminergic Influences on Brain Formation and Function
    GREGG STANWOOD; Fiscal Year: 2006
    ..abstract_text> ..
  55. Dopamine Function in TBI--Therapeutic Intervention
    Amy Wagner; Fiscal Year: 2005
    ..The Departments of Physical Medicine and Rehabilitation, Neurosurgery, Anesthesia/Critical Care Medicine, and Safar Center for Resuscitation Research provide the environment for this study of experimental and clinical brain injury. ..
  56. Brain and Behavioral Alterations After Methamphetamine
    William Melega; Fiscal Year: 2004
    ..This paradigm will represent a validated primate model to evaluate the efficacy of pharmacotherapies designed for treatment of neurological and behavioral deficits associated with human METH abuse. ..
  57. Cocaine Abuse and the Role of Gonadal Steroid Hormones
    NANCY MELLO; Fiscal Year: 2005
    ..Data obtained will help to clarify the neurobiologic substrates of cocaine abuse and may have heuristic implications for the development of new strategies for treatment. ..
  58. STRESS AND THE NEUROBIOLOGY OF DRUG AND ALCOHOL DEPENDE
    NICHOLAS GOEDERS; Fiscal Year: 2004
    ..The primary goal of this Training Program is to provide students and young scientists with comprehensive guidance in stress and drug abuse research. ..
  59. Influence of drugs of abuse on neuronal morphology
    Terry Robinson; Fiscal Year: 2005
    ....
  60. MURINE MODEL OF CAG REPEAT DISEASES
    Roger Albin; Fiscal Year: 2002
    ..These experiments will establish HPRT-CAG mice as important tools for understanding neurodegeneration in CAG repeat diseases and enable accurate preclinical evaluation of interventions for CAG repeat diseases. ..
  61. Selegiline Patch for Treatment of Nicotine Dependence
    Joel Killen; Fiscal Year: 2008
    ..abstract_text> ..
  62. Behavioral Model of Contextual Attention in the Monkey
    J Jentsch; Fiscal Year: 2003
    ..The development of such an approach to modeling contextual aspects of attention, in particular, in animals should be a major advance linking pre-clinical psychopharmacological studies and treatment-based research for schizophrenia. ..