dopamine antagonists

Summary

Summary: Drugs that bind to but do not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup.

Top Publications

  1. pmc A dopaminergic deficit hypothesis of schizophrenia: the path to discovery
    Arvid Carlsson
    Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Dialogues Clin Neurosci 8:137-42. 2006
  2. ncbi Evidence for the sensitivity of operant timing behaviour to stimulation of D1 dopamine receptors
    T H C Cheung
    Psychopharmacology Section, Division of Psychiatry, University of Nottingham, Room B109, Medical School, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Psychopharmacology (Berl) 195:213-22. 2007
  3. ncbi Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter
    S R Jones
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 18:1979-86. 1998
  4. ncbi Dissociation of Pavlovian and instrumental incentive learning under dopamine antagonists
    A Dickinson
    Department of Experimental Psychology, University of Cambridge, United Kingdom
    Behav Neurosci 114:468-83. 2000
  5. pmc Pharmacological modulation of subliminal learning in Parkinson's and Tourette's syndromes
    Stefano Palminteri
    Institut du Cerveau et de la Moëlle èpinière CR ICM, F 75013 Paris, France
    Proc Natl Acad Sci U S A 106:19179-84. 2009
  6. ncbi Distinct functions of the two isoforms of dopamine D2 receptors
    A Usiello
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, Illkirch, C U de Strasbourg, France
    Nature 408:199-203. 2000
  7. ncbi Multiple dopamine receptor subtypes in the medial prefrontal cortex of the rat regulate set-shifting
    Stan B Floresco
    Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, Canada
    Neuropsychopharmacology 31:297-309. 2006
  8. ncbi Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior
    Yukiori Goto
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Nat Neurosci 8:805-12. 2005
  9. ncbi Differential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior
    P Di Ciano
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 21:9471-7. 2001
  10. ncbi Different action on dopamine catabolic pathways of two endogenous 1,2,3,4-tetrahydroisoquinolines with similar antidopaminergic properties
    L Antkiewicz-Michaluk
    Institute of Pharmacology, Polish Academy of Sciences Krakow, Smetna 12, 31 343 Krakow, Poland
    J Neurochem 78:100-8. 2001

Detail Information

Publications304 found, 100 shown here

  1. pmc A dopaminergic deficit hypothesis of schizophrenia: the path to discovery
    Arvid Carlsson
    Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Dialogues Clin Neurosci 8:137-42. 2006
    ..It is currently informing clinical studies with novel partial dopamine antagonists (dopamine stabilizers) such as ACR16, which preferentially target extrasynaptic receptors while leaving ..
  2. ncbi Evidence for the sensitivity of operant timing behaviour to stimulation of D1 dopamine receptors
    T H C Cheung
    Psychopharmacology Section, Division of Psychiatry, University of Nottingham, Room B109, Medical School, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Psychopharmacology (Berl) 195:213-22. 2007
    ..It is not known whether this effect of d-amphetamine is mimicked by direct D(1)-like receptor stimulation...
  3. ncbi Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter
    S R Jones
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 18:1979-86. 1998
    ..Furthermore, these findings suggest that in the absence of pharmacological manipulation, such as the use of amphetamine, endogenous cytoplasmic DA normally does not reach sufficient concentrations to reverse the DAT...
  4. ncbi Dissociation of Pavlovian and instrumental incentive learning under dopamine antagonists
    A Dickinson
    Department of Experimental Psychology, University of Cambridge, United Kingdom
    Behav Neurosci 114:468-83. 2000
    The administration of the dopamine antagonists, pimozide and alpha-flupenthixol, to rats reduced Pavlovian-instrumental transfer when a conditioned stimulus (CS) that had been paired with a noncontingent food reward was tested on ..
  5. pmc Pharmacological modulation of subliminal learning in Parkinson's and Tourette's syndromes
    Stefano Palminteri
    Institut du Cerveau et de la Moëlle èpinière CR ICM, F 75013 Paris, France
    Proc Natl Acad Sci U S A 106:19179-84. 2009
    ..More generally, they suggest that pharmacological manipulation of dopamine transmission can subconsciously drive us to either get more rewards or avoid more punishments...
  6. ncbi Distinct functions of the two isoforms of dopamine D2 receptors
    A Usiello
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, Illkirch, C U de Strasbourg, France
    Nature 408:199-203. 2000
    ..The absence of D2L reveals that D2S inhibits D1 receptor-mediated functions, uncovering a circuit of signalling interference between dopamine receptors...
  7. ncbi Multiple dopamine receptor subtypes in the medial prefrontal cortex of the rat regulate set-shifting
    Stan B Floresco
    Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, Canada
    Neuropsychopharmacology 31:297-309. 2006
    ..These findings may have important implications for developing novel treatments for cognitive deficits observed in disorders such as attentional deficit and hyperactivity disorder and schizophrenia...
  8. ncbi Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior
    Yukiori Goto
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Nat Neurosci 8:805-12. 2005
    ..These results suggest that the dynamics of DA release regulate the balance between limbic and cortical drive through activation and inactivation of DA receptor subtypes in the accumbens, and this regulates goal-directed behavior...
  9. ncbi Differential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior
    P Di Ciano
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 21:9471-7. 2001
    ....
  10. ncbi Different action on dopamine catabolic pathways of two endogenous 1,2,3,4-tetrahydroisoquinolines with similar antidopaminergic properties
    L Antkiewicz-Michaluk
    Institute of Pharmacology, Polish Academy of Sciences Krakow, Smetna 12, 31 343 Krakow, Poland
    J Neurochem 78:100-8. 2001
    ..The results may explain the biochemical basis of the neuroprotective and of the neurotoxic properties endogenous brain tetrahydroisoquinoline derivatives...
  11. ncbi Impaired set-shifting and dissociable effects on tests of spatial working memory following the dopamine D2 receptor antagonist sulpiride in human volunteers
    Mitul A Mehta
    Department of Psychiatry, Level E4, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 176:331-42. 2004
    ..These include working memory and set-shifting deficits. Theories of DA function have predicted that distraction or impaired switching may be important determinants of such deficits...
  12. ncbi Dopamine is involved in food-anticipatory activity in mice
    Yuan Yuan Liu
    Department of Pharmacology, Shanghai Medical College, Fudan University, Shanghai, China
    J Biol Rhythms 27:398-409. 2012
    ..These results strongly indicate that the dopaminergic system plays an essential role in the FAA in mice...
  13. pmc Differential roles of dopamine D1 and D2 receptors in the nucleus accumbens in attentional performance on the five-choice serial reaction time task
    Marie Astrid Pezze
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 32:273-83. 2007
    ..The data are discussed in terms of the different functions of NAC dopamine receptors in the processing of information from its different cortico-limbic inputs...
  14. ncbi Remediation of attentional dysfunction in rats with lesions of the medial prefrontal cortex by intra-accumbens administration of the dopamine D(2/3) receptor antagonist sulpiride
    Marie A Pezze
    Department of Experimental Psychology, University of Cambridge, Downing St, Cambridge CB23EB, UK
    Psychopharmacology (Berl) 202:307-13. 2009
    ..The prefrontal cortex (PFC) and nucleus accumbens (NAC) are key brain loci considered to mediate many of the cognitive deficits associated with schizophrenia and related disorders...
  15. pmc The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence
    Christian A Heidbreder
    Centre of Excellence for Drug Discovery in Psychiatry, GlaxoSmithKline Pharmaceuticals, 37135 Verona, Italy
    Brain Res Brain Res Rev 49:77-105. 2005
    ..Provided these results can be extrapolated to human drug addicts, they suggest that selective DA D3 receptor antagonists may prove effective as potential pharmacotherapeutic agents to manage drug dependence and addiction...
  16. ncbi The effects of the dopamine D₃ receptor antagonist GSK598809 on attentional bias to palatable food cues in overweight and obese subjects
    Pradeep J Nathan
    Clinical Unit Cambridge, Medicines Discovery and Development, GlaxoSmithKline R and D, Cambridge, UK
    Int J Neuropsychopharmacol 15:149-61. 2012
    ....
  17. ncbi In vivo quantification of regional dopamine-D3 receptor binding potential of (+)-PHNO: Studies in non-human primates and transgenic mice
    Eugenii A Rabiner
    GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, London, UK
    Synapse 63:782-93. 2009
    ..The midbrain is thus an excellent target region to examine D3 receptor occupancy with [(11)C]-(+)-PHNO PET in vivo...
  18. ncbi Effect of domperidone on the composition of preterm human breast milk
    Marsha L Campbell-Yeo
    Women s and Newborn Health, IWK Health Centre, Halifax, Nova Scotia, Canada
    Pediatrics 125:e107-14. 2010
    ..Domperidone is increasingly prescribed to improve breast milk volume despite a lack of evidence regarding its effects on breast milk composition. We examined the effect of domperidone on the nutrient composition of breast milk...
  19. ncbi Effects of dopaminergic and serotonergic manipulation on emotional processing: a pharmacological fMRI study
    Hidehiko Takahashi
    Brain Imaging Project, National Institute of Radiological Sciences, Japan
    Neuroimage 27:991-1001. 2005
    ..At the same time, our findings suggest that pharmacological fMRI could be a powerful tool for investigating the neurophysiological properties of drugs targeting neuropsychiatric disorders...
  20. ncbi A mechanistic account of striatal dopamine function in human cognition: psychopharmacological studies with cabergoline and haloperidol
    Michael J Frank
    Department of Psychology and Program in NeuroscienceUniversity of Arizona, Tucson, AZ 85721, USA
    Behav Neurosci 120:497-517. 2006
    ..Drug effects interacted with baseline working memory span in all tasks. Taken together, the results support a unified account of the role of dopamine in modulating cognitive processes that depend on the basal ganglia...
  21. pmc Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist
    Ellen Y T Chien
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 330:1091-5. 2010
    ..This difference provides direction to the design of D3R-selective agents for treating drug abuse and other neuropsychiatric indications...
  22. ncbi Cognitive deficits and striato-frontal dopamine release in Parkinson's disease
    Nobukatsu Sawamoto
    Division of Neuroscience, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, UK
    Brain 131:1294-302. 2008
    ..In contrast, mesocortical dopaminergic transmission appears well preserved in early PD patients...
  23. ncbi Synergistic requirements for the induction of dopaminergic D1/D5-receptor-mediated LTP in hippocampal slices of rat CA1 in vitro
    Sheeja Navakkode
    Leibniz Institute for Neurobiology, Department of Neurophysiology, Magdeburg, Germany
    Neuropharmacology 52:1547-54. 2007
    ..e. NMDA-receptor activation. We provide first evidence that a synergistic role of D1/D5- as well as NMDA-receptor-function is required in mediating processes relevant for the maintenance of this protein synthesis-dependent potentiation...
  24. pmc Current perspectives on selective dopamine D(3) receptor antagonists as pharmacotherapeutics for addictions and related disorders
    Christian A Heidbreder
    Reckitt Benckiser Pharmaceuticals, Global Research and Development, Richmond, Virginia 23235, USA
    Ann N Y Acad Sci 1187:4-34. 2010
    ..Third, translational research from preclinical efficacy studies to so-called proof-of-concept studies for drug addiction indications will be discussed...
  25. ncbi Timing is everything: the effects of putative dopamine antagonists on metamorphosis vary with larval age and experimental duration in the prosobranch gastropod Crepidula fornicata
    Jan A Pechenik
    Biology Department, Tufts University, Medford, Massachusetts 02155, USA
    Biol Bull 202:137-47. 2002
    ..Surprisingly, the effects of the three putative dopamine antagonists tested (all at 10 microM) varied with exposure duration and the age of competent larvae...
  26. ncbi Dopamine antagonists alter response allocation but do not suppress appetite for food in rats: contrast between the effects of SKF 83566, raclopride, and fenfluramine on a concurrent choice task
    J D Salamone
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 160:371-80. 2002
    ..In previous work with this task, dopamine antagonists and accumbens dopamine depletions decreased lever pressing but increased chow consumption.
  27. ncbi Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 27:12700-6. 2007
    ....
  28. ncbi Blockade of [11C](+)-PHNO binding in human subjects by the dopamine D3 receptor antagonist ABT-925
    Ariel Graff-Guerrero
    PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Int J Neuropsychopharmacol 13:273-87. 2010
    ..Thus, [11C](+)-PHNO seems a suitable PET radiotracer to estimate D3 receptor occupancy in humans...
  29. pmc Cannabinoid CB1 antagonists and dopamine antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior
    K S Sink
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 196:565-74. 2008
    ..If this were true, then the effects of interference with cannabinoid CB1 transmission should closely resemble the effects of interference with DA transmission...
  30. ncbi D2-dopamine receptor blockade impairs motion detection in goldfish
    C Mora-Ferrer
    Institut für Zoologie III J Gutenberg Universität, Mainz, Germany
    Vis Neurosci 17:177-86. 2000
    ..The effect of sulpiride is discussed in relation to known sulpiride effects on retinal neurons and the retinal pigment epithelium...
  31. ncbi S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626
    M J Millan
    Department of Psychopharmacology, Institut de Recherches Servier, Centre de Recherches de Croissy, Paris, France
    J Pharmacol Exp Ther 293:1063-73. 2000
    ..S33084 should comprise a useful tool for further exploration of the pathophysiological significance of D(3)- versus D(2)-receptors...
  32. ncbi Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors
    A M Farrar
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuroscience 166:1056-67. 2010
    ..These findings may have implications for the treatment of psychiatric symptoms such as psychomotor slowing, anergia and fatigue...
  33. ncbi The dopamine D3 receptor: a therapeutic target for the treatment of neuropsychiatric disorders
    P Sokoloff
    INSERM, Unité de Neurobiologie et Pharmacologie, Moléculaire U573, Centre Paul Broca, 2ter rue d Alesia, 75014 Paris, France
    CNS Neurol Disord Drug Targets 5:25-43. 2006
    ..These data allow us to propose novel treatment options in PD, schizophrenia and drug addiction, which are awaiting evaluation in clinical trials...
  34. pmc Both stereoselective (R)- and (S)-1-Methyl-1,2,3,4-tetrahydroisoquinoline enantiomers protect striatal terminals against rotenone-induced suppression of dopamine release
    Lucyna Antkiewicz-Michaluk
    Department of Neurochemistry, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343, Krakow, Poland
    Neurotox Res 20:134-49. 2011
    ....
  35. ncbi 1-Methyl-1,2,3,4-tetrahydroisoquinoline enhances the anticonvulsant action of carbamazepine and valproate in the mouse maximal electroshock seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, 20 090 Lublin, Poland
    Neuropharmacology 50:133-42. 2006
    ..The antiseizure properties of 1-MeTHIQ (an endogenous parkinsonism-preventing substance) and its exact physiological role in the brain need extensive examination in further neuropharmacological studies...
  36. ncbi Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine
    John D Salamone
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Behav Brain Res 137:3-25. 2002
    ....
  37. pmc Positron emission tomography imaging of dopamine D₂/₃ receptors in the human cortex with [¹¹C]FLB 457: reproducibility studies
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 65:35-40. 2011
    ..These data support the further validation of [¹¹C]FLB 457 as a tool to measure amphetamine-induced dopamine release in the human cortex...
  38. ncbi Essential role of dopamine D2 receptor in the maintenance of wakefulness, but not in homeostatic regulation of sleep, in mice
    Wei Min Qu
    Department of Pharmacology, State Key Laboratory of Medical Neurobiology, Shanghai Medical College of Fudan University, Shanghai 200032, China
    J Neurosci 30:4382-9. 2010
    ..These results indicate that D(2)R plays an essential role in the maintenance of wakefulness, but not in homeostatic regulation of NREM sleep...
  39. ncbi Dopamine by itself activates either D2, D3 or D1/D5 dopaminergic receptors in normal human T-cells and triggers the selective secretion of either IL-10, TNFalpha or both
    Michal J Besser
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    J Neuroimmunol 169:161-71. 2005
    ....
  40. pmc Distinct contributions of dopamine in the dorsolateral striatum and nucleus accumbens shell to the reinforcing properties of cocaine
    Maartje M J Veeneman
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuropsychopharmacology 37:487-98. 2012
    ..We suggest that the DLS and the NAcc shell mediate somewhat distinct facets of the reinforcing properties of cocaine, related to its rewarding and motivational aspects, respectively...
  41. ncbi New serotonin/dopamine antagonists for the treatment of schizophrenia: are we making real progress?
    Nobumi Miyake
    Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY, USA
    Clin Schizophr Relat Psychoses 6:122-33. 2012
    ..This profile continues to be a favored model for developing new SGAs, commonly defined as serotonin/dopamine antagonists. In the past ten years, aripiprazole, paliperidone, asenapine, iloperidone, and lurasidone have been ..
  42. pmc A comparative evaluation of the dopamine D(2/3) agonist radiotracer [11C](-)-N-propyl-norapomorphine and antagonist [11C]raclopride to measure amphetamine-induced dopamine release in the human striatum
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh Medical Center Presbyterian, PET Facility, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Pharmacol Exp Ther 333:533-9. 2010
    ..Nevertheless, these data add to the growing literature that suggests D(2/3) agonist radiotracers are more vulnerable to endogenous competition by dopamine than existing D(2/3) antagonist radiotracers...
  43. ncbi Dopamine D3 receptor ligands for the treatment of tobacco dependence
    Bernard Le Foll
    Center for Addiction and Mental Health, Department of Family and Community Medicine, Psychiatry and Pharmacology, University of Toronto, 33 Russell Street, Toronto, ON M5S 2S1, Ontario, Canada
    Expert Opin Investig Drugs 16:45-57. 2007
    ..These preclinical studies suggest that the clinical evaluation of DRD3 ligands should be performed with clinical trials designed specifically to evaluate the relapse phenomena...
  44. pmc Dopaminergic drug effects on physiological connectivity in a human cortico-striato-thalamic system
    G D Honey
    University of Cambridge, Brain Mapping Unit, Department of Psychiatry, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Brain 126:1767-81. 2003
    ....
  45. ncbi Opposing roles of D1 and D2 receptors in appetitive conditioning
    Yaniv S Eyny
    Department of Psychology and Program in Neurobiology and Behavior, Columbia University, New York, New York 10027, USA
    J Neurosci 23:1584-7. 2003
    ....
  46. ncbi Role of muscles accumbens dopamine D1 and D2 receptors in instrumental and Pavlovian paradigms of conditioned reward
    M Koch
    Institut für Hirnforschung, Universitat Bremen, Germany
    Psychopharmacology (Berl) 152:67-73. 2000
    ..This study investigated the role of nucleus accumbens dopamine D1 and D2 receptors in two different paradigms of conditioned reward...
  47. ncbi The presence of background dopamine signal converts long-term synaptic depression to potentiation in rat prefrontal cortex
    Yoshiki Matsuda
    Laboratory of Neuromodulation, Neuronal Plasticity and Cognition, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7102 Neurobiologie des Processus Adaptatifs, Universite Paris VI Pierre et Marie Curie, 75005 Paris, France
    J Neurosci 26:4803-10. 2006
    ..We suggest that a role of background dopamine signals in the PFC is to prevent high-frequency synaptic inputs from abnormally inducing LTD and to secure the induction of LTP...
  48. ncbi Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York 10032, USA
    Synapse 60:485-95. 2006
    ..This property might contribute to its higher vulnerability to endogenous DA compared to [11C]raclopride and [11C]NPA...
  49. ncbi Dopaminergic and glutamatergic regulation of effort- and delay-based decision making
    Stan B Floresco
    Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, BC, Canada
    Neuropsychopharmacology 33:1966-79. 2008
    ..Furthermore, they suggest that dopamine and NMDA receptors make dissociable contributions to these different types of cost-benefit analyses...
  50. pmc Effect of domperidone on milk production in mothers of premature newborns: a randomized, double-blind, placebo-controlled trial
    O P da Silva
    Department of Pediatrics, University of Western Ontario, St Joseph s Health Care London, London, Ont
    CMAJ 164:17-21. 2001
    ..The objective of this study was to investigate the efficacy of domperidone in augmenting milk production in mothers of premature newborns...
  51. ncbi A double-blind, randomized, placebo-controlled study of the dopamine D₃ receptor antagonist ABT-925 in patients with acute schizophrenia
    Laura Redden
    Abbott, Abbott Park, IL, USA
    J Clin Psychopharmacol 31:221-5. 2011
    ....
  52. pmc Differential actions of adenosine A1 and A2A antagonists on the effort-related effects of dopamine D2 antagonism
    John D Salamone
    Division of Behavioral Neuroscience, Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Behav Brain Res 201:216-22. 2009
    ....
  53. ncbi Truth, lies or self-deception? Striatal D(2/3) receptor availability predicts individual differences in social conformity
    Alice Egerton
    Institute of Psychiatry, King s College London, London, UK
    Neuroimage 53:777-81. 2010
    ..54 p=0.06) but not SDE (r=0.23, ns). Whilst these associations are modest, results suggest that striatal D(2/3) receptor availability may be particularly associated with social conformity, rather than self-deception...
  54. ncbi Blockade of dopamine D₃ but not D₂ receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment
    David J G Watson
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Int J Neuropsychopharmacol 15:471-84. 2012
    ..These data support further investigation of the potential use of dopamine D₃ receptor antagonists to treat schizophrenia...
  55. ncbi The dose-dependent effect of chronic administration of haloperidol, risperidone, and quetiapine on sexual behavior in the male rat
    Xiang Rong Zhang
    Neuropsychiatric Research Institute, School of Clinical Medicine, Southeast University, Nanjing, China
    J Sex Med 8:3345-53. 2011
    ..Up to date, there is still a scarcity of basic research regarding the chronic effects of most antipsychotic agents on sexual behavior...
  56. ncbi Adenosine A2A receptor antagonism and genetic deletion attenuate the effects of dopamine D2 antagonism on effort-based decision making in mice
    M Pardo
    Area de Psicobiologia, Campus de Riu Sec, Universitat Jaume I, 12071 Castello, Spain
    Neuropharmacology 62:2068-77. 2012
    ..These results indicate that DA D(2) and adenosine A(2A) receptors interact to regulate effort-related decision making and effort expenditure in mice...
  57. ncbi Potentiation of opioid analgesia in dopamine2 receptor knock-out mice: evidence for a tonically active anti-opioid system
    M A King
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Neurosci 21:7788-92. 2001
    ..Thus, dopamine D(2) receptors represent an additional, significant modulatory system that inhibits analgesic responses to mu and kappa opioids...
  58. ncbi Modulation of latent inhibition in the rat by altered dopamine transmission in the nucleus accumbens at the time of conditioning
    M H Joseph
    MRC Behavioural Neurochemistry Group and Department of Psychology, Institute of Psychiatry, Denmark Hill, SE5 8AF, London, UK
    Neuroscience 101:921-30. 2000
    ..The implications of these conclusions for theories linking disrupted latent inhibition to the attentional deficits in schizophrenia, and to the dopamine theory of this disorder, are discussed...
  59. ncbi The effects of dopamine and D2 receptor antagonists on pituitary hormone secretion are intact in mice lacking dopamine D2L receptor
    Rong Xu
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Brain Res 939:95-9. 2002
    ..These results suggest that D2S can substitute for the function of D2L in the regulation of pituitary hormone secretion, and that the function of D2S is not dependent on the formation of a receptor heterodimer with D2L...
  60. ncbi Dopamine D1 receptors synergize with D2, but not D3 or D4, receptors in the striatum without the involvement of action potentials
    G J LaHoste
    Department of Psychology, University of New Orleans, New Orleans, Louisiana 70148, USA
    J Neurosci 20:6666-71. 2000
    ....
  61. pmc The flexible approach hypothesis: unification of effort and cue-responding hypotheses for the role of nucleus accumbens dopamine in the activation of reward-seeking behavior
    Saleem M Nicola
    Department of Psychiatry and Behavioral Science and Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 30:16585-600. 2010
    ..The flexible approach hypothesis provides a unified framework for understanding the contribution of the accumbens and its dopamine projection to reward-seeking behavior...
  62. ncbi Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, 00133 Rome, Italy
    J Neurosci 23:8506-12. 2003
    ....
  63. ncbi Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning
    Christoph Kellendonk
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, New York 10032, USA
    Neuron 49:603-15. 2006
    ..We found that D2R overexpression in the striatum impacts dopamine levels, rates of dopamine turnover, and activation of D1 receptors in the prefrontal cortex, measures that are critical for working memory...
  64. ncbi Positron emission tomography imaging of amphetamine-induced dopamine release in the human cortex: a comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C]FLB 457 and [11C]fallypride
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 63:447-61. 2009
    ..These findings suggest that [(11)C]FLB 457 is superior to [(11)C]fallypride for measurement of changes in cortical synaptic dopamine...
  65. ncbi Neuroendocrine responsivities of the pituitary dopamine system in male schizophrenic patients during treatment with clozapine, olanzapine, risperidone, sulpiride, or haloperidol
    M Markianos
    Athens University Medical School, Psychiatric Clinic, Eginition Hospital Vass Sophias 74 Athens 11528, Greece
    Eur Arch Psychiatry Clin Neurosci 251:141-6. 2001
    ..m. administered haloperidol, since the expected elevations depend mainly on the free remaining D2 receptors in the tuberoinfundibular tract...
  66. ncbi Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section and Stockholm Brain Institute, R5 02, Karolinska Hospital, 17176, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 36:1639-50. 2009
    ..This study assessed the quantitative improvements provided by the implementation of the PSF modelling in the reconstruction of the PET data using the High Resolution Research Tomograph (HRRT)...
  67. ncbi Mice with reduced NMDA receptor expression display behaviors related to schizophrenia
    A R Mohn
    Department of Medicine, University of North Carolina at Chapel Hill 27599 USA
    Cell 98:427-36. 1999
    ..These findings support a model in which reduced NMDA receptor activity results in schizophrenic-like behavior and reveals how pharmacological manipulation of monoaminergic pathways can affect this phenotype...
  68. ncbi Activation of phosphatidylinositol-linked D1-like receptor modulates FGF-2 expression in astrocytes via IP3-dependent Ca2+ signaling
    Xinhua Zhang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 29:7766-75. 2009
    ..PI-linked D(1)-like receptor plays an important role in the regulation of astrocytic FGF-2 expression and neuroprotection which may provide a potential target for the drug discovery in Parkinson's disease...
  69. ncbi Dopamine release in the human striatum: motor and cognitive tasks revisited
    Julia M Lappin
    Institute of Psychiatry, King s College London, London, UK
    J Cereb Blood Flow Metab 29:554-64. 2009
    ..No additional DA release was observed specific to the cognitive component of either task...
  70. ncbi Heterosynaptic co-activation of glutamatergic and dopaminergic afferents is required to induce persistent long-term potentiation
    Colin M O'Carroll
    Department of Neuroscience, 1, George Square, University of Edinburgh, Edinburgh EH8 9JZ, UK
    Neuropharmacology 47:324-32. 2004
    ....
  71. ncbi Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models
    Sridhar Natesan
    Schizophrenia Program and the PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 31:1854-63. 2006
    ..Partial agonism of aripiprazole offers a good explanation for this dissociation and provides a framework for understanding occupancy-functional relationships of partial D2 agonist antipsychotics...
  72. ncbi Effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline on the behavioral effects of cocaine in rats
    M Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Physiol Pharmacol 58:625-39. 2007
    ..Moreover, a dissociation between effects of 1MeTIQ on cocaine vs. food-maintained responding was demonstrated...
  73. ncbi The role of dopamine in conditioning and latent inhibition: what, when, where and how?
    Andrew M J Young
    Behavioural Neuroscience Group, School of Psychology, University of Leicester, University Road, Leicester LE1 9HN, UK
    Neurosci Biobehav Rev 29:963-76. 2005
    ..We suggest that this common significance might be the broadening of attention to take in potentially conditionable stimuli, which have previously been devalued...
  74. ncbi 1-Methyl-1,2,3,4-tetrahydroisoquinoline and established uncompetitive NMDA receptor antagonists induce tolerance to excitotoxicity
    Magdalena Kuszczyk
    Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, PL 02 106 Warszawa, Poland
    Pharmacol Rep 62:1041-50. 2010
    ..Moreover, our data disclose a new mechanism of 1MeTIQ-evoked neuroprotection based on the induction of neuronal tolerance to excitotoxicity...
  75. pmc The dopamine D2 receptor antagonist sulpiride modulates striatal BOLD signal during the manipulation of information in working memory
    Chris M Dodds
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 207:35-45. 2009
    ..Dopamine (DA) plays an important role in working memory. However, the precise functions supported by different DA receptor subtypes in different neural regions remain unclear...
  76. ncbi 1-Methyl-1,2,3,4-tetrahydroisoquinoline antagonizes a rise in brain dopamine metabolism, glutamate release in frontal cortex and locomotor hyperactivity produced by MK-801 but not the disruptions of prepulse inhibition, and impairment of working memory in
    Małgorzata Pietraszek
    Department of Neuro Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343, Krakow, Poland
    Neurotox Res 16:390-407. 2009
    ..However, 1MeTIQ did not attenuate sensorimotor gating deficit or working memory impairment evoked by MK-801 which may be served as a model of negative symptoms of schizophrenia...
  77. ncbi The hedonic response to cigarette smoking is proportional to dopamine release in the human striatum as measured by positron emission tomography and [11C]raclopride
    Sean P Barrett
    McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Canada
    Synapse 54:65-71. 2004
    ..These results suggest that pleasurable drug experiences are associated with increased dopamine transmission in the dorsal striatum while unpleasant experiences may be related to decreased dopamine release in this region...
  78. ncbi 1-methyl-1,2,3,4-tetrahydroisoquinoline protects against rotenone-induced mortality and biochemical changes in rat brain
    Lucyna Antkiewicz-Michaluk
    Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Eur J Pharmacol 466:263-9. 2003
    ....
  79. ncbi Reproducibility of [11 C]FLB 457 binding in extrastriatal regions
    Y Sudo
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Nucl Med Commun 22:1215-21. 2001
    ..These results support the suitability of using [11C]FLB 457 for the quantitative evaluation of extrastriatal D2 receptors and for protocols requiring repeated measurements in the same individual...
  80. ncbi The structural evolution of dopamine D3 receptor ligands: structure-activity relationships and selected neuropharmacological aspects
    Frank Boeckler
    Department of Medicinal Chemistry, Emil Fischer Center, Friedrich Alexander University Erlangen Nurnberg, Schuhstrasse 19, 91052 Erlangen, Germany
    Pharmacol Ther 112:281-333. 2006
    ....
  81. ncbi Neurobiological basis of serotonin-dopamine antagonists in the treatment of Gilles de la Tourette syndrome
    Thomas D L Steeves
    Division of Neurology, University of Toronto, Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Ontario, Canada
    Prog Brain Res 172:495-513. 2008
    ..This information, when placed in the context of the observed functional imaging abnormalities, may generate further insights into the pathophysiology of TS...
  82. ncbi Comparison of rat dopamine D2 receptor occupancy for a series of antipsychotic drugs measured using radiolabeled or nonlabeled raclopride tracer
    Vanessa N Barth
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA
    Life Sci 78:3007-12. 2006
    ..The observation that in vivo application of both techniques led to comparable data adds to the validation state of the mass spectroscopy-based approach to receptor occupancy assays...
  83. ncbi The D(3) dopamine receptor inhibits dopamine release in PC-12/hD3 cells by autoreceptor signaling via PP-2B, CK1, and Cdk-5
    Pei Chun Chen
    School of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA
    J Neurochem 110:1180-90. 2009
    ....
  84. pmc Skill-memory consolidation in the striatum: critical for late but not early long-term memory and stabilized by cocaine
    Ingo Willuhn
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Behav Brain Res 199:103-7. 2009
    ..Furthermore, cocaine appeared to stabilize motor-memory formation by protecting consolidation processes after the training...
  85. ncbi S33138 (N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1] benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenyl-acetamide), a preferential dopamine D3 versus D2 receptor antagonist and potential antipsychotic agent: III. Actions in models of therapeutic activi
    Mark J Millan
    Institut de Recherches Servier, Centre de Recherches de Croissy, Psychopharmacology Department, 125 Chemin de Ronde, 78290 Croissy sur Seine, France
    J Pharmacol Exp Ther 324:1212-26. 2008
    ..In comparison with clinically available agents, S33138 displays, thus, a distinctive and promising profile of potential antipsychotic properties...
  86. ncbi Effects of dopamine antagonists with different receptor blockade profiles on morphine-induced place preference in male mice
    C Manzanedo
    , , Universitat de Valencia, Aptdo. 22109, 46071 Valencia, Spain
    Behav Brain Res 121:189-97. 2001
    ..U-99194A maleate did not reverse morphine-induced CPP. These results suggest that the conditioned rewarding effects of morphine are mediated by the different subtypes of DA receptors...
  87. pmc Motor-skill learning in a novel running-wheel task is dependent on D1 dopamine receptors in the striatum
    I Willuhn
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Neuroscience 153:249-58. 2008
    ..Furthermore, our findings demonstrate that D1 receptors in the striatum are critical for consolidation of long-term skill memory...
  88. ncbi Adenosine A(2A) receptor antagonism reverses the effects of dopamine receptor antagonism on instrumental output and effort-related choice in the rat: implications for studies of psychomotor slowing
    Andrew M Farrar
    Department of Psychology, University of Connecticut, Storrs, CT, 06269 1020, USA
    Psychopharmacology (Berl) 191:579-86. 2007
    ..Dopamine antagonism and accumbens dopamine depletions cause rats performing on choice tasks to reallocate their behavior away from food-reinforced tasks that have high response requirements...
  89. ncbi Dopamine is not required for the hyperlocomotor response to NMDA receptor antagonists
    Elena H Chartoff
    Department of Psychiatry, Harvard Medical School, McLean Hospital Belmont, MA, USA
    Neuropsychopharmacology 30:1324-33. 2005
    ..These results suggest that glutamate, rather than dopamine, is required for the locomotor and molecular effects of NMDA receptor antagonists, but that glutamate and dopamine can act cooperatively...
  90. pmc Selective blockade of dopamine D3 receptors enhances while D2 receptor antagonism impairs social novelty discrimination and novel object recognition in rats: a key role for the prefrontal cortex
    David J G Watson
    School of Biomedical Sciences, Queen s Medical Centre, The University of Nottingham, Nottingham, UK
    Neuropsychopharmacology 37:770-86. 2012
    ..These data have important implications for exploitation of dopaminergic mechanisms in the treatment of schizophrenia and other CNS disorders, and support the potential therapeutic utility of dopamine D(3) receptor antagonism...
  91. pmc Olfactoretinal centrifugal input modulates zebrafish retinal ganglion cell activity: a possible role for dopamine-mediated Ca2+ signalling pathways
    Luoxiu Huang
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    J Physiol 569:939-48. 2005
    ..Together, the data suggest that olfactory input has a modulatory effect on RGC firing, and that this effect is mediated by dopamine D1 receptor-coupled Ca2+ signalling pathways...
  92. ncbi The role of dopamine D3 compared with D2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats
    Mark J Millan
    Psychopharmacology Department, Institut de Recherches Servier, Centre de Recherches de Croissy, 125 Chemin de Ronde, 78290 Croissy Seine, Paris, France
    Psychopharmacology (Berl) 174:341-57. 2004
    ..The role of dopamine D(3)/D(2) receptors in the control of locomotion is poorly understood...
  93. pmc Dopamine receptors in human lymphocytes: radioligand binding and quantitative RT-PCR assays
    Galina P Kirillova
    Center for Education and Drug Abuse Research, Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Neurosci Methods 174:272-80. 2008
    ..The expression levels were comparable with those in the brain for DRD3 and DRD4, and were significantly lower for DRD2 and DRD5...
  94. ncbi Dopamine D2 receptor density and personal detachment in healthy subjects
    A Breier
    Experimental Therapeutics Branch, NIMH, Bethesda, MD, USA
    Am J Psychiatry 155:1440-2. 1998
    ..The purpose of this study was to examine the relationship between the personality trait involving personal detachment and dopamine D2 receptor specific binding in healthy subjects...
  95. ncbi Galactogogues: medications that induce lactation
    Michael P Gabay
    Drug Information and Medication Use Outcomes Section, University of Illinois at Chicago, USA
    J Hum Lact 18:274-9. 2002
    ..Finally, a natural product, fenugreek, has been purported to be effective in anecdotal reports. Use of this agent may be warranted after considering risks versus benefits...
  96. ncbi Thioridazine induces apoptosis of multidrug-resistant mouse lymphoma cells transfected with the human ABCB1 and inhibits the expression of P-glycoprotein
    Gabriella Spengler
    Institute of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Anticancer Res 31:4201-5. 2011
    ....
  97. pmc Dopaminergic mechanisms of reinstatement of MDMA-seeking behaviour in rats
    S Schenk
    Victoria University of Wellington, School of Psychology, Wellington, New Zealand
    Br J Pharmacol 162:1770-80. 2011
    ..Animal models of drug-seeking suggest that exposure to cues associated with self-administered drugs and drug primes might precipitate relapse via activation of central dopaminergic substrates...
  98. ncbi The effect of sulpiride on amphetamine-induced disruption of overshadowing in the rat
    Colm P O'Tuathaigh
    School of Psychology, University of Leicester, University Rd, Leicester LE1 7RH, UK
    Prog Neuropsychopharmacol Biol Psychiatry 28:1249-53. 2004
    ..The results are in agreement with previous data indicating that DA modulation of stimulus selection performance is mediated by activation of the DA D1 rather than DA D2 receptor subtype...
  99. ncbi Cholinergic neuronal modulation alters dopamine D2 receptor availability in vivo by regulating receptor affinity induced by facilitated synaptic dopamine turnover: positron emission tomography studies with microdialysis in the conscious monkey brain
    H Tsukada
    Central Research Laboratory, Hamamatsu Photonics K K, Shizuoka 434 8601, Japan
    J Neurosci 20:7067-73. 2000
    ....
  100. ncbi Modifications in DARPP-32 phosphorylation pattern after repeated palatable food consumption undergo rapid habituation in the nucleus accumbens shell of non-food-deprived rats
    Barbara Danielli
    Department of Neuroscience, Pharmacology Unit, University of Siena, Siena, Italy
    J Neurochem 112:531-41. 2010
    ..Thus, dopamine D(1) receptor stimulation plays a role in the development of habituation...
  101. ncbi The dopamine D3 receptor antagonist, S33138, counters cognitive impairment in a range of rodent and primate procedures
    Mark J Millan
    Institut de Recherches Servier, Croissy sur Seine, France
    Int J Neuropsychopharmacol 13:1035-51. 2010
    ..These data underpin interest in D(3) receptor blockade as a strategy for improving cognitive performance in CNS disorders like schizophrenia and Parkinson's disease...

Research Grants62

  1. STIMULANTS, DEPRESSANTS & HALLUCINOGENS AS REINFORCERS
    Gail Winger; Fiscal Year: 2003
    ..to maintain responding will be tested, and the effects of several serotonin antagonists and several dopamine antagonists on the reinforcing effects of these drugs will be measured as well. 6...
  2. Photoreceptor Rescue By Inhibition of Dopamine Signaling
    JUDITH OGILVIE; Fiscal Year: 2006
    ..We have discovered that dopamine antagonists from either the D1- or D2-receptor families completely block the degeneration of photoreceptors in the rd1 ..
  3. In-vivo Modulation of Synapses by Endocannabinoids
    Alberto Pereda; Fiscal Year: 2009
    ..abstract_text> ..
  4. Validation of Measures of Restless Legs Syndrome for Elders with Memory Disorders
    Kathy Richards; Fiscal Year: 2009
    ..be present in elders with dementia because they often have RLS risk factors like iron deficiency and taking dopamine antagonists. Motor activity such as leg movement, signs of leg discomfort such as rubbing the legs, and iron deficiency ..
  5. Cocaine behavior: Regulation by k-opioids and serotonin
    Sari Izenwasser; Fiscal Year: 2009
    Many different compounds can block the behavioral effects of cocaine acutely. For example, dopamine antagonists, opioid antagonists and serotonin uptake inhibitors can all reduce cocaine self-administration...
  6. Development of a Human Hydrolase to Treat Cocaine Abuse and Overdose: Rat Models
    WILLIAM STEPHEN BRIMIJOIN; Fiscal Year: 2011
    ..This application will investigate whether direct treatment or gene therapy with this enzyme can reduce drug-seeking behavior in rats as a model for cocaine addiction in humans. ..
  7. VESTIBULO-CEREBELLAR CIRCUITS
    CAREY DAVID BALABAN; Fiscal Year: 2013
    ..These studies will identify potential common sites of action of opioids, dopamine antagonists and antimigraine agents (e.g...
  8. Correction of obesity by optogenetic manipulation of striatal neurons
    ELIZABETH KATHERINE SCHWARTZ; Fiscal Year: 2013
    ..few decades have shown that dopamine agonists often cause weight loss and decreased food reward, whereas dopamine antagonists often lead to weight gain (and often the metabolic syndrome), and increased food reward...
  9. Dopamine Neurotransmission in Tourette Syndrome
    Rajendra D Badgaiyan; Fiscal Year: 2013
    ..Thus, symptomatic relief following administration of dopamine antagonists suggests hyperactivity of the dopamine system but the hyperactivity is not consistently supported by the ..
  10. Neural Mechanisms of Heroin-induced Conditioned Immunomodulation
    DONALD T contact LYSLE; Fiscal Year: 2010
    ..abstract_text> ..
  11. Effects of Cannabinoids on Pain-Stimulated and Pain-Depressed Behavior in Rats
    Andrew J Kwilasz; Fiscal Year: 2013
    ..Importantly, pain-induced depression of ICSS is not blocked by kappa opioid agonists and dopamine antagonists, drugs that produce false positive antinociception in assays of pain-stimulated behavior but are ..
  12. NEURONAL SUBSTRATES OF COCAINE REWARD
    George F Koob; Fiscal Year: 2013
    ..release in the mesolimbic dopamine system, and inhibitory G-protein function, and increased sensitivity to dopamine antagonists and partial agonists...
  13. Do 'schizophrenia-like'decreases in cortical GABA function impair cognition?
    TRACIE ANN PAINE; Fiscal Year: 2012
    ..Gaining a better understanding of the role of cortical GABA dysfunction in the cognitive deficits in schizophrenia may lead to improved treatment strategies. ..
  14. Nucleus Accumbens Processing of Reward-predictive Cues
    Saleem M Nicola; Fiscal Year: 2013
    ..this encoding, using a powerful new technique developed in our lab for applying pharmacological compounds (dopamine antagonists and agonists) to the neurons we record from in behaving animals...
  15. Center for the Neurobiology of Addiction Treatment
    Steven R Childers; Fiscal Year: 2013
    ..will begin with topiramate, and proceed with other potential treatment agents including modafinil, D3 dopamine antagonists, orexin antagonists, and others...
  16. Neurotoxicity of NMDA Receptor Antagonists
    Frank Sharp; Fiscal Year: 2005
    ..abstract_text> ..
  17. Subtype Specific Agonists for D1-D5 Dopamine Receptors
    William Goddard; Fiscal Year: 2007
    ..Moreover these computational methods developed and refined in this project can be applied for other more complex GPCR systems like the lipid and peptide receptors. [unreadable] [unreadable]..
  18. Developmental Psychopharmacology of Antipsychotics
    JENNY WILEY; Fiscal Year: 2007
    ..hypotheses of this grant proposal are that (1) developing animals are more sensitive to the effects of dopamine antagonists, including antipsychotics, on motor processes than are adult animals and (2) chronic dosing with ..
  19. POLYDRUG ABUSE IN WOMEN
    NANCY MELLO; Fiscal Year: 2000
    ....
  20. DOPAMINE IN NEONATAL HYPOXIC-ISCHEMIC BRAIN INJURY
    Francis Filloux; Fiscal Year: 1992
    ..The potential neuroprotective effects of a depleter of endogenous dopamine (alpha-methyl-ptyrosine), of dopamine antagonists, both non-selective (fluphenazine and flupenthioxl) and selective (SCH 23390; sulpiride), and of ..
  21. ANTIPSYCHOTIC TREATMENT IN LATE LIFE SCHIZOPHRENIA
    Jonathan Lacro; Fiscal Year: 2001
    ..Recently, experience with serotonin- dopamine antagonists, or "atypical" antipsychotic medications such as clozapine and risperidone, has shown that is possible to ..
  22. NEUROPEPTIDASES AND CAROTID BODY FUNCTIONS
    Ganesh Kumar; Fiscal Year: 2000
    ..These studies may also yield new information in the development of enzyme based therapeutic agents in the treatment of hypoxemia, associated with high altitude adaptation and chronic obstructive lung diseases. ..
  23. Optogenetic Manipulation of Brain Reward
    Luis de Lecea; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: This proposal will use state of the art methods to identify neuronal structures involved in brain reward function. ..
  24. Dopamine and Iron in Restless Legs Syndrome
    Christopher Earley; Fiscal Year: 2006
    ..restless legs syndrome is exquisitely sensitive to dopamine agents and aggravated or precipitated by dopamine antagonists. Previous studies and our pilot data are consistent with an involvement of brain iron and dopamine in the ..
  25. SENSORY GATING AND HABITUATION IN SCHIZOPHRENIA
    David Braff; Fiscal Year: 2002
    ..We intend to further our understanding of how DA overactivity and its underlying neuroanatomic correlates may relate to the specific cognitive dysfunction, symptoms, and outcome of the schizophrenic disorders. ..
  26. SEROTONERGIC MODULATION OF AMYGDALOID TRANSMISSION
    Donald Rainnie; Fiscal Year: 2001
    ..3) Examination of the effects of chronic APDs administration on intrinsic membrane properties, synaptic transmission, and 5-HTergic modulation of BLA and ACe neurones. ..
  27. DOPAMINERGIC CONTROL OF TISSUE RENIN
    Jack Barrett; Fiscal Year: 1991
    ....
  28. HT/DA SYSTEM INTERACTION IN PSYCHOSTIMULANT DRUG EFFECTS
    Manuel Tancer; Fiscal Year: 2002
    ..dopamine agonists and antagonists, have not replicated animal findings and treatment approaches using dopamine antagonists have not been successful...
  29. PHARMACOTHERAPY OF COCAINE ADDICTION
    Reese Jones; Fiscal Year: 2000
    ..as efforts to test the value of the aforementioned concept for developing medications, for example, NMDA or dopamine antagonists. The concept that "anti-cocaine" medications will have therapeutic utility will be tested with D3 agonists, ..
  30. RAT MODELS TO SCREEN COMPOUNDS INDUCING SLOW-WAVE SLEEP
    Bernard Bergmann; Fiscal Year: 2003
    ..These new compounds will represent a major breakthrough in the treatment of conditions and illnesses which involve disturbed sleep. ..
  31. NMDA-based treatment of schizophrenia
    MARK KLITENICK; Fiscal Year: 2002
    ..Current treatment approaches for schizophrenia rely on the use of dopamine antagonists (antipsychotics)...
  32. Therapy for self-injurious behavior in autism
    George Wagner; Fiscal Year: 2003
    ..these behaviors have been linked to dysfunction of brain dopamine but, unfortunately, clinical trials with dopamine antagonists have met with poor results...
  33. Role of the mPFC in reinstatement of drug seeking
    SHARON MALINAK; Fiscal Year: 2005
    ..In order to further assess the role of specific dopamine receptors in cocaine relapse, selective dopamine antagonists will also be administered directly into the mPFC prior to a systemic priming injection of cocaine...
  34. BASAL GANGLIA OUTPUT AND PSYCHOSTIMULANT ABUSE
    Heinz Steiner; Fiscal Year: 2009
    ..This work will help establish an improved cellular framework necessary to understand and successfully treat cocaine addiction. ..
  35. MODULATION OF RETINAL FUNCTION
    Xiong Li Yang; Fiscal Year: 1992
    ..influences in preparations whose interplexiform cells are destroyed with 6-OHDA and studying the effects of dopamine antagonists on the centrifugal influences in normal intact preparations...
  36. Genetics of Addictive Drug Responsiveness
    Tristan Darland; Fiscal Year: 2006
    ..Finally, we will further characterize the current mutant candidates using additional behavioral tests, anatomical analysis and molecular genetics. [unreadable] [unreadable] [unreadable] [unreadable]..
  37. Dopamine D4 Receptor in Sustained Attention
    Kehong Zhang; Fiscal Year: 2003
    ..The findings may also provide a pharmacological basis for innovative treatment for ADHD to replace stimulant therapy. ..
  38. A Simple Measure for Studying Sensory Gating Deficits
    Neal Swerdlow; Fiscal Year: 2007
    ..abstract_text> ..
  39. Neural basis of heritable DA-mediated gating deficits
    Neal R Swerdlow; Fiscal Year: 2010
    ....
  40. NEURAL CIRCUITRY OF SENSORIMOTOR GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2006
    ....
  41. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal R Swerdlow; Fiscal Year: 2010
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  42. Neuroscience at the Boundaries of Neurology and Psychiatry
    Neal Swerdlow; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  43. PASSIVE IMMUNITY TO COCAINE USING NOVEL HUMAN ANTIBODIES
    Andrew Norman; Fiscal Year: 2003
    ..These studies will form the basis for an application to the FDA for advancement of an identified human monoclonal anti-cocaine antibody to Phase II clinical trials to determine the efficacy of a passive immunotherapy of cocaine abuse. ..
  44. Lateral Hypothalamus, Dopamine and Ingestive Behavior
    David Wirtshafter; Fiscal Year: 2007
    ..Gaining an understanding of these systems is a prerequisite for the rational development of novel treatments for disturbances of ingestion, such as occur in obesity, bulemia and cahchexia. [unreadable] [unreadable] [unreadable]..
  45. BASAL GANGLIA CIRCUITRY IMMEDIATE EARLY GENE EXPRESSION
    David Wirtshafter; Fiscal Year: 2003
    ..Other studies will examine the effects of lesions within the basal ganglia on the IEG expression induced by systemic administration of dopaminergic drugs. ..
  46. BEHAVIORAL EFFECTS OF NIGRAL D1 ANTAGONISM
    John Salamone; Fiscal Year: 2001
    ....
  47. MOTOR EFFECTS OF ATYPICAL ANTIPSYCHOTICS
    John Salamone; Fiscal Year: 2003
    ..Taken together, the results of these experiments will help to identify the pharmacological characteristics and brain circuits that underlie the motor effects of clozapine. ..
  48. Dopamine D2 and Adenosine A2A roles:Tremulous Movements
    John Salamone; Fiscal Year: 2007
    ..abstract_text> ..
  49. Effort-related Functions of Nucleus Accumbens Adenosine A2A Receptors
    John D Salamone; Fiscal Year: 2010
    ....
  50. Neurochemistry of Nicotine Dependence in Schizophrenia
    Wynne Schiffer; Fiscal Year: 2004
    ..Or increase inhibitory activity with the GABA agonist, gamma-vinyl GABA, prior to the nicotine challenge. We hope to guide the development of novel therapies for dual-diagnosis schizophrenia. ..
  51. Role of D3 dopamine receptor in behavioral sensitization
    NEIL RICHTAND; Fiscal Year: 2007
    ..Significantly, these studies may also elucidate a previously unrecognized mechanism regulating receptor desensitization and trafficking relevant to other receptor systems and pathological conditions. ..
  52. PET Imaging of Mesolimbic Dopamine in Heroin Dependence
    Diana Martinez; Fiscal Year: 2007
    ..abstract_text> ..
  53. GHB: Discrimination and effects on learning
    Lisa Baker; Fiscal Year: 2003
    ..Behavior under these assays is sensitive to other abused drugs. Therefore, these assays may be of value in characterizing the effects of GHB. ..
  54. Behavior Therapy for Adults with Tourette Syndrome
    Lawrence Scahill; Fiscal Year: 2009
    ..The Informatics group at Yale University will provide data management services. ..
  55. ALCOHOLISM AND ENDOGENOUS OPIOID ACTIVITY
    Gary Wand; Fiscal Year: 2008
    ..Fortype specifications, see instructions onpage 6.) RESEARCH GRANT TABLE OF CONTENTS PageNumbers Face Page 1 Description, ..
  56. Treatments for Nicotine Dependence: Brain Mechanisms
    Arthur Brody; Fiscal Year: 2005
    ..abstract_text> ..
  57. CNS Mechanisms that Modulate Reward
    KENNETH CARR; Fiscal Year: 2008
    ..The research proposed in this application is aimed at elucidating midbrain and striatal mechanisms involved in the increased behavioral responsiveness of FR rats to drugs of abuse. ..
  58. Small Animal PET (microPET)
    JOGESH MUKHERJEE; Fiscal Year: 2007
    ..abstract_text> ..
  59. Gene expression associated with the CNS reinforcing act*
    ZACHARY RODD HENRICKS; Fiscal Year: 2003
    ..The results of the proposed project will provide valuable information on neuronal systems and receptors within the extended amygdala involved in mediating the rewarding properties of alcohol. ..
  60. RUPP-PI Program at Yale University
    Lawrence Scahill; Fiscal Year: 2006
    ..Furthermore, this five-site network has established reliability on several measures that are relevant to the conduct of clinical trials in children with PDD. ..