adrenergic alpha agonists

Summary

Summary: Drugs that selectively bind to and activate alpha adrenergic receptors.

Top Publications

  1. pmc Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302
    J Sallinen
    Orion Corporation Orion Pharma, Research and Development, Turku, Finland
    Br J Pharmacol 150:391-402. 2007
  2. ncbi Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: patient and clinician perceptions
    R M Venn
    Department of Anaesthesia and Intensive Care, Worthing Hospital, West Sussex, UK
    Br J Anaesth 87:684-90. 2001
  3. ncbi alpha2A-adrenoceptor stimulation reduces capsaicin-induced glutamate release from spinal cord synaptosomes
    X Li
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1009, USA
    J Pharmacol Exp Ther 299:939-44. 2001
  4. ncbi Cholinergic, noradrenergic, and serotonergic inhibition of fast synaptic transmission in spinal lumbar dorsal horn of rat
    P Li
    Department of Anesthesiology, Washington University Pain Center, Washington University in St. Louis, St. Louis, MO 61103, USA
    Brain Res Bull 54:639-47. 2001
  5. ncbi Extracellular signal-regulated kinase 1/2-mediated transcriptional regulation of G-protein-coupled receptor kinase 3 expression in neuronal cells
    Samina Salim
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204 5037, USA
    J Pharmacol Exp Ther 321:51-9. 2007
  6. ncbi Effect of brimonidine on retinal ganglion cell survival in an optic nerve crush model
    Ke Ma
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China
    Am J Ophthalmol 147:326-31. 2009
  7. ncbi Contribution of both Ca2+ entry and Ca2+ sensitization to the alpha1-adrenergic vasoconstriction of rat penile small arteries
    Nuria Villalba
    Departamento de Fisiologia, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Am J Physiol Heart Circ Physiol 292:H1157-69. 2007
  8. ncbi The noradrenergic alpha2 agonist clonidine modulates behavioural and neuroanatomical correlates of human attentional orienting and alerting
    J T Coull
    Wellcome Department of Cognitive Neurology, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
    Cereb Cortex 11:73-84. 2001
  9. ncbi Effects of radolmidine, a novel alpha2 -adrenergic agonist compared with dexmedetomidine in different pain models in the rat
    M Xu
    Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Helsinki, Helsinki University Hospital, Finland
    Anesthesiology 93:473-81. 2000
  10. pmc Nuclear Ca2+ sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes
    Dali Luo
    Department of Pharmacology, School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China
    Cell Calcium 43:165-74. 2008

Research Grants

  1. SYMPATHETIC FIBER MODULATION OF NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2003
  2. Neuropeptide Regulation Vasopressin/Oxytocin Secretion
    CELIA SLADEK; Fiscal Year: 2006
  3. HORMONAL REGULATION OF ENERGY METABOLISM
    Tarun Patel; Fiscal Year: 1991
  4. STIMULUS PROPERTIES OF COCAINE
    JAMES O DONNELL; Fiscal Year: 1990
  5. VASCULAR ALPHA ADRENERGIC RECEPTORS
    R Alexander; Fiscal Year: 1990
  6. CONTROL OF RENIN SECRETION
    PAUL CHURCHILL; Fiscal Year: 1993
  7. MECHANISM OF CENTRALLY-ACTING ANTIHYPERTENSIVE DRUGS
    Jerry Buccafusco; Fiscal Year: 1991
  8. REGULATION OF VASCULAR ALPHA1--ADRENERGIC RESPONSES
    Wilson Colucci; Fiscal Year: 2000
  9. NEURAL CONTROL OF RENIN SECRETION
    MARTHA BLAIR; Fiscal Year: 1980
  10. Retinal ganglion cell loss in aging mice.
    Thomas Mittag; Fiscal Year: 2007

Detail Information

Publications212 found, 100 shown here

  1. pmc Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302
    J Sallinen
    Orion Corporation Orion Pharma, Research and Development, Turku, Finland
    Br J Pharmacol 150:391-402. 2007
    ..The current study describes a novel highly selective alpha2C-adrenoceptor antagonist, JP-1302 (acridin-9-yl-[4-(4-methylpiperazin-1-yl)-phenyl]amine)...
  2. ncbi Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: patient and clinician perceptions
    R M Venn
    Department of Anaesthesia and Intensive Care, Worthing Hospital, West Sussex, UK
    Br J Anaesth 87:684-90. 2001
    ..The rate pressure product is reduced in patients receiving dexmedetomidine, which may protect against myocardial ischaemia. Dexmedetomidine reduces the requirement for opioid analgesia...
  3. ncbi alpha2A-adrenoceptor stimulation reduces capsaicin-induced glutamate release from spinal cord synaptosomes
    X Li
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1009, USA
    J Pharmacol Exp Ther 299:939-44. 2001
    ....
  4. ncbi Cholinergic, noradrenergic, and serotonergic inhibition of fast synaptic transmission in spinal lumbar dorsal horn of rat
    P Li
    Department of Anesthesiology, Washington University Pain Center, Washington University in St. Louis, St. Louis, MO 61103, USA
    Brain Res Bull 54:639-47. 2001
    ..Our results support the hypothesis that descending sensory modulation may be mediated by multiple neurotransmitter receptors in the spinal cord...
  5. ncbi Extracellular signal-regulated kinase 1/2-mediated transcriptional regulation of G-protein-coupled receptor kinase 3 expression in neuronal cells
    Samina Salim
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204 5037, USA
    J Pharmacol Exp Ther 321:51-9. 2007
    ..Taken together, our results demonstrate the involvement of the ERK1/2 pathway in selective up-regulation of GRK3 mRNA expression, possibly via activation of Sp-1 and Ap-2 transcription factors in neuronal cells...
  6. ncbi Effect of brimonidine on retinal ganglion cell survival in an optic nerve crush model
    Ke Ma
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China
    Am J Ophthalmol 147:326-31. 2009
    ..To investigate the effect of brimonidine on the retinal ganglion cell survival in an optic nerve crush model...
  7. ncbi Contribution of both Ca2+ entry and Ca2+ sensitization to the alpha1-adrenergic vasoconstriction of rat penile small arteries
    Nuria Villalba
    Departamento de Fisiologia, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Am J Physiol Heart Circ Physiol 292:H1157-69. 2007
    ..A capacitative Ca(2+) entry coupled to noncontractile functions of the smooth muscle cell is also demonstrated...
  8. ncbi The noradrenergic alpha2 agonist clonidine modulates behavioural and neuroanatomical correlates of human attentional orienting and alerting
    J T Coull
    Wellcome Department of Cognitive Neurology, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
    Cereb Cortex 11:73-84. 2001
    ..Furthermore, we have demonstrated lateralized neuroanatomical substrates for the noradrenergic modulation of human attentional orienting in the spatial and temporal domains...
  9. ncbi Effects of radolmidine, a novel alpha2 -adrenergic agonist compared with dexmedetomidine in different pain models in the rat
    M Xu
    Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Helsinki, Helsinki University Hospital, Finland
    Anesthesiology 93:473-81. 2000
    ..This study determined the antinociceptive and sedative effects of radolmidine in different models of acute and chronic pain. Dexmedetomidine and saline served as controls...
  10. pmc Nuclear Ca2+ sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes
    Dali Luo
    Department of Pharmacology, School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China
    Cell Calcium 43:165-74. 2008
    ....
  11. pmc Actions of noradrenaline on substantia gelatinosa neurones in the rat spinal cord revealed by in vivo patch recording
    Motoki Sonohata
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Physiol 555:515-26. 2004
    ....
  12. pmc Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences
    Igor Mitrovic
    Department of Physiology, University of California, San Francisco, 94143, USA
    Proc Natl Acad Sci U S A 100:271-6. 2003
    ..Finally, our results suggest that the reduced pain responsiveness of male compared with female mice results in part from GIRK2-coupled postsynaptic receptors that are activated by endogenous antinociceptive systems...
  13. ncbi alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy
    Carolyn A Fairbanks
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Pharmacol Exp Ther 300:282-90. 2002
    ..These results confirm that the alpha(2C)AR subtype contributes to spinal antinociception and synergy with opioids...
  14. ncbi Remodeling of the cardiac pacemaker L-type calcium current and its beta-adrenergic responsiveness in hypertension after neuronal NO synthase gene transfer
    Daniel A Heaton
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford, United Kingdom
    Hypertension 48:443-52. 2006
    ..Decreased calcium current after cardiac nNOS gene transfer contributes to the normalization of beta-adrenergic hyperresponsiveness in the SAN from hypertensive rats by modulating cyclic nucleotide signaling...
  15. ncbi Evidence for the role of alpha1D- and alpha1A-adrenoceptors in contraction of the rat mesenteric artery
    Luz Elena Arévalo-León
    Instituto de Investigaciones Quimico Biologicas, Universidad Michoacana de San Nicolas de Hidalgo, Morelia, Mich, Mexico
    Vascul Pharmacol 40:91-6. 2003
    ..Data suggest that alpha(1D)-adrenoceptors predominate for contraction in mesenteric artery of the Wistar rat, with a second population of alpha(1A)-adrenoceptors responding at high agonist concentrations...
  16. ncbi Does segmental difference in alpha 1-adrenoceptor subtype explain contractile difference in rat abdominal and thoracic aortae?
    Juan Asbun-Bojalil
    Sección de Estudios de Posgrado e Investigación de la Escuela Superior de Medicina, IPN Plan de San Luis y Diaz Miron, Col Casco de Sto Tomas, 17, Mexico 11340, DF, Mexico
    Vascul Pharmacol 38:169-75. 2002
    ..The results of this study suggest that the contraction to phenylephrine of the rat abdominal and thoracic aorta is mediated via the same alpha 1D-AR subtype...
  17. ncbi Tizanidine. A review of its pharmacology, clinical efficacy and tolerability in the management of spasticity associated with cerebral and spinal disorders
    A J Wagstaff
    Adis International Limited, Auckland, New Zealand
    Drugs 53:435-52. 1997
    ..Tizanidine, therefore, appears to be an attractive therapeutic alternative for patients with spasticity associated with cerebral or spinal damage...
  18. ncbi Effects of norepinephrine on rat cultured microglial cells that express alpha1, alpha2, beta1 and beta2 adrenergic receptors
    Kohji Mori
    Department of Physiology, School of Medicine, Ehime University, Shigenobu, Ehime 791 0295, Japan
    Neuropharmacology 43:1026-34. 2002
    ..Clonidine upregulated the expression of mRNA encoding an anti-apoptotic factor Bcl-xL. These results suggest that norepinephrine participates in the regulation of brain function at least partly by modulating the functions of microglia...
  19. ncbi Topical apraclonidine testing discloses pupillary sympathetic denervation in diabetic patients
    Feray Koc
    Neuro Ophthalmology Unit, SB Ulucanlar Eye Hospital, Ankara, Turkey
    J Neuroophthalmol 26:25-9. 2006
    ..Pupillary sympathetic denervation (PSD) has been found in Horner syndrome following instillation of apraclonidine 0.5%. We have applied this technique to investigate the prevalence of PSD in DM...
  20. pmc Characterization of alpha1-adrenoceptor subtypes mediating contractions to phenylephrine in rat thoracic aorta, mesenteric artery and pulmonary artery
    M B Hussain
    Department of Pharmacology, University College London
    Br J Pharmacol 122:849-58. 1997
    ..The data for both BMY 7378 and MDL73005EF in all three blood vessels are consistent with receptor heterogeneity. However, the identity of the second site is unclear...
  21. ncbi Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding
    J R Jasper
    Center for Biological Research, Neurobiology Unit, Roche Bioscience, Palo Alto, CA 94304, USA
    Biochem Pharmacol 55:1035-43. 1998
    ..This report provides a functional characterization of adrenergic receptor ligands at human and mouse alpha2a/d AR. It also illustrates the utility of [35S]GTPgammaS incorporation as a functional marker of receptor activation...
  22. ncbi Presynaptic inhibition by noradrenaline of the EPSC evoked in neonatal rat sympathetic preganglionic neurons
    T Miyazaki
    Department of Physiology, Tokyo Medical College, 6 1 1 Shinjuku, Shinjuku ku, Tokyo 160, Japan
    Brain Res 790:170-7. 1998
    ..These results indicate that activation of presynaptic alpha2A-adrenoceptors on inputs to SPNs decreases glutamate release...
  23. ncbi A pilot study of topical treatment with an alpha2-agonist in patients with retinal dystrophies
    Saul Merin
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Ocul Pharmacol Ther 24:80-6. 2008
    ..The aim of this study was to assess the neuroprotective effect of a topical alpha2-agonist in patients with retinal dystrophies...
  24. ncbi Inhibition of glutamatergic synaptic input to spinal lamina II(o) neurons by presynaptic alpha(2)-adrenergic receptors
    Yu Zhen Pan
    Department of Anesthesiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033 0850, USA
    J Neurophysiol 87:1938-47. 2002
    ....
  25. pmc Action of dexmedetomidine on the substantia gelatinosa neurons of the rat spinal cord
    Hideaki Ishii
    Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi, Niigata 951 8510, Japan
    Eur J Neurosci 27:3182-90. 2008
    ..This action of dexmedetomidine might contribute, at least in part, to its antinociceptive action in the spinal cord...
  26. ncbi Effects of noradrenaline on neuronal NOS2 expression and viability
    Jose L M Madrigal
    Department of Anesthesiology, University of Illinois, and VA Chicago Health Care System, 60612, USA
    Antioxid Redox Signal 8:885-92. 2006
    ..Perturbations of NA could exacerbate neuronal damage by allowing for increased inflammatory responses...
  27. pmc Structure-function of alpha1-adrenergic receptors
    Dianne M Perez
    Department of Molecular Cardiology, NB5, The Cleveland Clinic Foundation, Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Biochem Pharmacol 73:1051-62. 2007
    ..This review will explore past and current knowledge of the structure-function of the alpha(1)-adrenergic receptor subtypes...
  28. ncbi Neuroprotective effects of brimonidine treatment in a rodent model of ischemic optic neuropathy
    Nataliya O Danylkova
    Department of Ophthalmology, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Eye Res 84:293-301. 2007
    ..These results suggest that brimonidine may have potential use for prevention of ION in at-risk patients...
  29. pmc Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine
    A B Malmberg
    Department of Anatomy, W M Keck Center for Integrative Neuroscience, University of California, San Francisco, California, CA 94143, USA
    Br J Pharmacol 132:1827-36. 2001
    ....
  30. ncbi Norepinephrine facilitates inhibitory transmission in substantia gelatinosa of adult rat spinal cord (part 1): effects on axon terminals of GABAergic and glycinergic neurons
    H Baba
    Department of Anesthesiology, Niigata University School of Medicine, Japan
    Anesthesiology 92:473-84. 2000
    ..In addition, it is possible that norepinephrine affects transmitter release in the substantia gelatinosa...
  31. ncbi Effects of a topical alpha2 adrenergic agonist on ciliary blood flow and aqueous production in rabbits
    H A Reitsamer
    Department of Ophthalmology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Exp Eye Res 82:405-15. 2006
    ..01), EVP (-42%, p<0.01) and ciliary PO2 (-32%, p<0.05). We conclude that topical brimonidine is a ciliary vasoconstrictor, and that alpha2 adrenergic agonist-induced decreases in ciliary blood flow decrease aqueous production...
  32. ncbi In vivo gene modification elucidates subtype-specific functions of alpha(2)-adrenergic receptors
    J W Kable
    Department of Pharmacology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Pharmacol Exp Ther 293:1-7. 2000
    ..Although these genetic approaches have limitations, they have significantly increased our understanding of the functions of alpha(2)-adrenergic receptor subtypes...
  33. ncbi Cellular G protein-coupled receptor kinase levels regulate sensitivity of the {alpha}2b-adrenergic receptor to undergo agonist-induced down-regulation
    Aarti N Desai
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204 5037, USA
    J Pharmacol Exp Ther 312:767-73. 2005
    ....
  34. ncbi Selective effects of clonidine and temazepam on attention and memory
    Brian Tiplady
    Department of Anaesthesia, Intensive Care, and Pain Medicine, University of Edinburgh, Edinburgh, UK
    J Psychopharmacol 19:259-65. 2005
    ..These results support the suggestion that central noradrenergic function may be involved in preventing distraction, but do not confirm other reports suggesting that some aspects of performance are improved with clonidine...
  35. ncbi Central hypotensive effects of the alpha2a-adrenergic receptor subtype
    L B MacMillan
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Science 273:801-3. 1996
    ..The hypotensive response to alpha2AR agonists was lost in the mutant mice, demonstrating that the alpha2aAR subtype plays a principal role in this response...
  36. ncbi Inhibition by brimonidine of forskolin-induced nitrite production in isolated pig ciliary processes
    Rong Liu
    Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Switzerland
    Invest Ophthalmol Vis Sci 43:2727-31. 2002
    ..To investigate by which mechanism the ocular hypotensive drug brimonidine (selective alpha(2)-adrenoreceptor agonist) inhibits the production of nitrite induced by forskolin in isolated porcine ciliary processes...
  37. ncbi Identification of novel inhibitors of calling and in vitro [14C]acetate incorporation by pheromone glands of Plodia interpunctella
    A Hirashima
    Department of Applied Genetics and Pest Management, Faculty of Agriculture, Graduate School, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Pest Manag Sci 57:713-20. 2001
    ..The results of the present study indicate that these derivatives could provide useful information in the characterization and differentiation of octopaminergic receptor types and subtypes...
  38. ncbi Frequency dependent alpha(2)-adrenoceptor mediated modulation of excitatory junction potentials in guinea-pig mesenteric artery
    V N Mutafova-Yambolieva
    Department of Physiology and Cell Biology, Anderson Medical Building MS 352, University of Nevada School of Medicine, 89557 0046, Reno, NV, USA
    Eur J Pharmacol 411:123-127. 2001
    ..2-2 Hz in reserpine-treated arteries. In conclusion, pre-junctional alpha(2)-adrenoceptors modulate ATP release during low frequency, brief duration sympathetic nerve stimulation...
  39. ncbi A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors
    K M Small
    Departments of Medicine and Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 275:23059-64. 2000
    ....
  40. pmc Tail arteries from chronically spinalized rats have potentiated responses to nerve stimulation in vitro
    Melanie Yeoh
    Prince of Wales Medical Research Institute, Randwick, NSW 2031, Australia
    J Physiol 556:545-55. 2004
    ..This hyper-reactivity may contribute to the genesis of autonomic dysreflexia in patients...
  41. ncbi Noradrenergic inputs mediate state dependence of auditory responses in the avian song system
    Jessica A Cardin
    Department of Biology and Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:7745-53. 2004
    ..Our results demonstrate that noradrenergic release in a single forebrain area is a mechanism underlying behavioral state-dependent regulation of auditory processing in a neural system specialized for vocal learning...
  42. ncbi Evidence that alpha(1B)-adrenoceptors are involved in noradrenaline-induced contractions of rat tail artery
    Sven Jähnichen
    Institute of Pharmacy, Free University of Berlin, Konigin Luise Str 2 4, Berlin 14195, Germany
    Eur J Pharmacol 488:157-67. 2004
    ....
  43. ncbi Noradrenaline release in rat locus coeruleus is regulated by both opioid and alpha(2) -adrenoceptors
    Tohru Nakai
    Department of Clinical Pharmacology, Hokkaido College of Pharmacy, 7 1 Katsuraoka cho, Otaru, Hokkaido 047 02, Japan
    Pharmacol Res 45:407-12. 2002
    ..These results directly suggest that NA increased within the LC after the naloxone challenge in morphine-dependent animals pretreated with yohimbine may be, at least in part, regulated by alpha(2) -adrenoceptors in the LC...
  44. ncbi (+)-Cyclazosin, a selective alpha1B-adrenoceptor antagonist: functional evaluation in rat and rabbit tissues
    Gabriella Marucci
    Department of Chemical Sciences, University of Camerino, Italy
    Eur J Pharmacol 522:100-7. 2005
    ..Furthermore, (+)-cyclazosin displayed a significant selectivity for alpha(1B)-adrenoceptors relative to the alpha(1L)-subtype...
  45. ncbi alpha2-Adrenoceptor-mediated modulation of the release of GABA and noradrenaline in the rat substantia nigra pars reticulata
    Amal Alachkar
    Faculty of Life Sciences, University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Neurosci Lett 395:138-42. 2006
    ....
  46. ncbi Role of noradrenergic system in the mechanism of action of endogenous neurotoxin 1,2,3,4-tetrahydroisoquinoline: biochemical and functional studies
    Jerzy Michaluk
    Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Pol J Pharmacol 54:19-25. 2002
    ..The results may also support the hypothesis assuming a causal relationship between noradrenergic dennervation, activity of the nigrostriatal dopamine system, and some clinical manifestation of Parkinson's disease...
  47. ncbi Carvedilol blockade of rat myocardial alpha1-adrenoceptors
    Eirik Qvigstad
    Department of Pharmacology, University of Oslo, P O Box 1057 Blindern, N 0316 Oslo, Norway
    Eur J Pharmacol 481:83-9. 2003
    ..Thus, carvedilol antagonizes the myocardial alpha(1)-adrenoceptors with a 9-fold lower potency than the beta-adrenoceptors. Antagonism of myocardial alpha(1)-adrenoceptor evoked effects may contribute to clinical effects of carvedilol...
  48. ncbi Existence of functional alpha1A- and alpha1D- but no alpha1B-adrenoceptor subtypes in rat common carotid arteries
    Shigetoshi Chiba
    Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan
    Jpn J Pharmacol 88:146-50. 2002
    ..From these results, it is concluded that there are functional alpha1A- and alpha1D-adrenoceptor subtypes in rat common carotid arteries, but no functional alpha1B subtype...
  49. ncbi Norepinephrine increases alveolar fluid reabsorption and Na,K-ATPase activity
    Zaher S Azzam
    Medical Service, Veteran Affairs Chicago Health Care System, Illinois, USA
    Am J Respir Crit Care Med 170:730-6. 2004
    ..These effects are due to increased activity and abundance of the Na,K-ATPase in the basolateral membrane of ATII cells...
  50. ncbi Activation of subfornical organ neurons in rats through pre- and postsynaptic alpha-adrenoceptors
    Eiko Honda
    Department of Biosciences, Kyushu Dental College, 2 6 1 Manazuru, Kokurakitaku, Kitakyushu 803 8580 Japan
    Am J Physiol Regul Integr Comp Physiol 290:R1646-53. 2006
    ..The results suggest that SFO neurons in rats are activated postsynaptically through alpha1-adrenoceptors and that the activation is enhanced by suppressing GABAergic inhibitory synaptic inputs through presynaptic alpha2-adrenoceptors...
  51. ncbi Noradrenergic regulation of prolactin secretion at the level of the paraventricular nucleus of the hypothalamus: functional significance of the alpha-1b and beta-adrenergic receptor subtypes
    James C Dodge
    Behavioral Neuroscience Program, Psychology Department, SUNY at Buffalo, USA
    Brain Res 1016:240-6. 2004
    ..The results of this study indicate that both the alpha-1b and beta-adrenergic receptor subtypes have a significant role in regulating circulating levels of prolactin at the level of the PVN in the Siberian hamster...
  52. ncbi Reduced cortical noradrenergic neurotransmission is associated with increased neophobia and impaired spatial memory in aged rats
    Timothy J Collier
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Tech 2000, Suite 200, 2242 W Harrison St, Chicago, IL 60612, USA
    Neurobiol Aging 25:209-21. 2004
    ..The results suggest that an aging-related reduction in cortical NE neurotransmission is associated with the expression of increased neophobia and deficits in spatial learning and memory performance occurring with advanced age in rats...
  53. ncbi Mediation of contraction in rat cauda epididymidis by alpha-adrenoceptors
    G Chaturapanich
    Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    Reproduction 124:887-92. 2002
    ..The results suggest that contraction of the proximal cauda epididymidis of rats is mediated by both alpha(1)- and alpha(2)-adrenoceptors. The latter appears to be more abundant...
  54. ncbi Autoreceptor-mediated inhibition of norepinephrine release in rat medial prefrontal cortex is maintained after chronic desipramine treatment
    April S Garcia
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 91:683-93. 2004
    ..Together, these data suggest that endogenous activation of alpha(2)-autoreceptors persists in restraining NA neurotransmission in the face of tonically elevated basal NA levels following chronic reuptake blockade...
  55. ncbi Neuronal norepinephrine responses of the rostral ventrolateral medulla and nucleus tractus solitarius neurons distinguish the I1- from the alpha2-receptor-mediated hypotension in conscious SHRs
    Guichu Li
    Department of Pharmacology, Brody School of Medicine, Greenville, North Carolina 27858 4353, USA
    J Cardiovasc Pharmacol 46:52-62. 2005
    ..The potential confounding effects of anesthetics on the I1 and/or alpha2 receptor-mediated neuronal and cardiovascular responses were circumvented in the present study...
  56. ncbi An antidepressant mechanism of desipramine is to decrease tumor necrosis factor-alpha production culminating in increases in noradrenergic neurotransmission
    J L Reynolds
    Department of Pathology and Anatomical Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA
    Neuroscience 133:519-31. 2005
    ..Thus, the efficacy of desipramine is due to decreased levels of TNF in the brain induced by this drug, ultimately modifying noradrenergic neurotransmission...
  57. ncbi Lack of interaction between orexinergic and alpha2-adrenergic neuronal systems in rat cerebrocortical slices
    Kazuyoshi Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8563, Japan
    Neurosci Lett 387:49-52. 2005
    ..50+/-0.34 (77.6+/-10.9%); orexin A was ineffective. The present data suggest a lack of interaction between orexinergic and alpha2-adrenergic neurons in rat cerebral cortex...
  58. ncbi Dual effect of agmatine in the bisected rat vas deferens
    Wilson C Santos
    Departamento de Farmácia e Administração Farmaceutica, UFF, Faculdade de Farmacia, 24241 000, Niteroi, RJ, Brasil
    J Pharm Pharmacol 55:373-80. 2003
    ..It was concluded that agmatine interferes with sympathetic neurotransmission, but the physiological relevance of this needs to be better understood because of the high doses employed to induce its effects...
  59. ncbi Effects of norepinephrine on alpha-subtype receptors in the feline pulmonary vascular bed
    Alan D Kaye
    Department of Anesthesiology, Texas Tech University Health Sciences Center, Lubbock, TX, USA
    Crit Care Med 32:2300-3. 2004
    ..To test the hypothesis that norepinephrine induces a pressor response in the pulmonary vascular bed of the cat and identify the alpha-(1)adrenoceptor subtypes involved in the mediation or modulation of these effects...
  60. ncbi Desensitization of the inhibitory effect of norepinephrine on insulin secretion from pancreatic islets of exercise-trained rats
    Yuriko Urano
    Department of Kinesiology, Graduate School of Sciene, Tokyo Metropolitan University, Tokyo 192 0397, Japan
    Metabolism 53:1424-32. 2004
    ....
  61. ncbi The functional alpha-adrenoceptor in dog caudal vesical arteries is mainly an alpha1A subtype
    M Nakazawa
    Department of Pharmacology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Auton Autacoid Pharmacol 22:253-9. 2002
    ....
  62. ncbi Adrenoceptor mechanisms underlying imipramine-induced memory deficits in rats
    Mohammad Reza Zarrindast
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    J Psychopharmacol 17:83-8. 2003
    ..Yohimbine pretreatment attenuated the effect of clonidine. It is concluded that alpha2-adrenoceptor mechanism(s) may be involved in imipramine-induced impairment of memory...
  63. ncbi The role of alpha-adrenoceptors in the amnestic effect of intracerebroventricular dexamethasone
    Mohammad Reza Zarrindast
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P O Box 13145 784, Tehran, Iran
    Pharmacol Res 46:339-44. 2002
    ..These data suggest that dexamethasone may induce its amnestic effect through activation of alpha(2)-adrenoceptors, leading to decreased alpha(1)-adrenergic activity...
  64. ncbi Effects of imipramine on the expression and development of morphine dependence in mice
    Mohammad Reza Zarrindast
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P O Box 13145 784, Tehran, Iran
    Eur J Pharmacol 473:19-25. 2003
    ..It is concluded an alpha2-adrenoceptor mechanism may be involved in the influence of imipramine on the expression and development of naloxone-induced withdrawal signs in mice...
  65. ncbi Pharmacological characterization of alpha1-adrenoceptors in mouse isolated femoral small arteries
    Joseph Zacharia
    Department of Biological and Biomedical Sciences, School of Life Sciences, Glasgow Caledonian University, Glasgow G4 0BA, Scotland, UK
    Eur J Pharmacol 503:155-63. 2004
    ..alpha1D-adrenoceptors are not involved in responses to exogenous noradrenaline but appear to be activated by neurally released noradrenaline at a low frequency of stimulation...
  66. ncbi Effect of clonidine on colonic motility in rats
    Teruyasu Umezawa
    Department of Physiology, School of Medical Sciences, Showa University, Hatanodai 1 5 8, Shinagawa, Tokyo 142 8555, Japan
    Auton Neurosci 107:32-6. 2003
    ..The results of the present study suggested that clonidine inhibits colonic motility in rats through activation of central alpha(2)-adrenergic receptor...
  67. ncbi Locus coeruleus activity in perinatally protein-deprived rats: effects of fluoxetine administration
    Alejandro O Sodero
    Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, 5016, Cordoba, Argentina
    Eur J Pharmacol 503:35-42. 2004
    ..These results stress the complexity of plastic changes induced by early protein malnutrition and sustain the hypothesis that perinatally protein-deprived rats may represent a useful animal model for screening antipanic agents...
  68. ncbi Critical involvement of dopaminergic neurotransmission in impulsive decision making
    Marcel M van Gaalen
    Department of Medical Pharmacology, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, Free University Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 60:66-73. 2006
    ..Commonly prescribed for this condition, amphetamine (Adderall), reduces impulsive decision making; however, the neuropharmacologic mechanism of this effect of amphetamine is unclear...
  69. ncbi A pharmacological modulation of opiate withdrawal using an up-/down-regulation of the noradrenergic system in opiate-dependent rats
    Emmanuel Streel
    Universite Libre de Bruxelles, CHU Brugmann, Service de Psychiatrie, Clinique d Alcoologie et Toxicomanies, Laboratoire de recherche sur la biologie des dépendances, Bruxelles, Belgium
    Int J Neuropsychopharmacol 9:621-6. 2006
    ..These results may have various applications in clinical opiate detoxification protocols and are discussed through an up-/down- regulation of adrenoreceptors...
  70. ncbi Pre- and postjunctional alpha(2)-adrenergic receptors in fetal and adult ovine cerebral arteries
    John M Bishai
    Center for Perinatal Biology, Department of Physiology, Loma Linda University School of Medicine, Loma Linda, California 92350, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1654-62. 2002
    ..We conclude that in fetal and adult ovine cerebral arteries, alpha(2)-AR appear to be chiefly prejunctional. Nonetheless, the fetal cerebral arteries appear to have a significant component of postjunctional alpha(2)-AR...
  71. ncbi Potentiation by yohimbine of alpha-adrenoceptor-mediated vasoconstriction in response to clonidine in the rabbit ear vein
    Ding Zhao
    School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei, PR China
    Eur J Pharmacol 589:201-5. 2008
    ....
  72. ncbi Alpha1A-adrenergic receptors are functionally expressed by a subpopulation of cornu ammonis 1 interneurons in rat hippocampus
    Kristin L Hillman
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Stop 9037, Grand Forks, North Dakota 58202 9037, USA
    J Pharmacol Exp Ther 321:1062-8. 2007
    ..Together, our results provide strong evidence to support functional expression of alpha(1A)ARs in a subpopulation of CA1 interneurons...
  73. ncbi Adrenergic control of a constitutively active acetylcholine-regulated potassium current in canine atrial cardiomyocytes
    Yung Hsin Yeh
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada, and First Cardiovascular Division, Chang Gung Memorial Hospital, Chang Gung University, Tao Yuan, Taiwan
    Cardiovasc Res 74:406-15. 2007
    ..Adrenergic stimulation favors atrial arrhythmogenesis but its effects on IKH are poorly understood...
  74. pmc Characterization of the postjunctional alpha 2C-adrenoceptor mediating vasoconstriction to UK14304 in porcine pulmonary veins
    T Görnemann
    Institut fur Pharmazie, Freie Universitat Berlin, Berlin, Germany
    Br J Pharmacol 151:186-94. 2007
    ..Therefore, we characterized the alpha(2)-adrenoceptor subtypes mediating contraction in isolated porcine pulmonary veins...
  75. ncbi Alpha1A-adrenoceptors predominate in the control of blood pressure in mouse mesenteric vascular bed
    S G Martínez-Salas
    Escuela Militar de Graduados de Sanidad, Universidad del Ejercito y Fuerza Aerea, Secretaría de la Defensa Nacional, Mexico, D F
    Auton Autacoid Pharmacol 27:137-42. 2007
    ..6 The results indicate that the isolated mouse mesenteric vascular bed expresses alpha1A-adrenoceptors and suggest a very discrete role for 1B-adrenoceptors...
  76. ncbi Effects of castration on alpha 1-adrenoceptor subtypes in the rat aorta
    Paola de Lucena Morais
    Department of Pharmacology, Instituto de Biociencias, UNESP, 18618 000 Botucatu, SP, Brazil
    Vascul Pharmacol 39:335-41. 2002
    ..76 +/- 0.09). These results suggest that castration induces plasticity in the alpha 1-adrenoceptor subtypes involved in the contractions of the aorta to noradrenaline...
  77. ncbi Role of selective alpha and beta adrenergic receptor mechanisms in rat jejunal longitudinal muscle contractility
    Roland Seiler
    Gastroenterology Unit Prof U Scheurer, University Hospital Bern, University of Bern, Bern, Switzerland
    J Gastrointest Surg 12:1087-93. 2008
    ..TTX reduced the inhibition by RI. Our results suggest that muscular alpha1, beta2, and beta3 receptor mechanisms mediate adrenergic inhibition of contractility in rat jejunum. beta2 mechanisms seem to involve also neural pathways...
  78. ncbi Role of brain adrenoceptors in the corticortopin-releasing factor-induced central activation of sympatho-adrenomedullary outflow in rats
    Mieko Yorimitsu
    Department of Pharmacology, Graduate School of Medicine, Kochi University, Nankoku, Japan
    Life Sci 82:487-94. 2008
    ..Furthermore, central alpha(2) adrenoceptors are involved in modulating the CRF-induced elevation of both plasma catecholamines...
  79. ncbi The role of Kupffer cell alpha(2)-adrenoceptors in norepinephrine-induced TNF-alpha production
    M Zhou
    Center for Surgical Research and Department of Surgery, School of Medicine, The University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, AL 35294, USA
    Biochim Biophys Acta 1537:49-57. 2001
    ....
  80. pmc Evidence for a functional alpha 1A- (alpha 1C-) adrenoceptor mediating contraction of the rat epididymal vas deferens and an alpha 1B-adrenoceptor mediating contraction of the rat spleen
    R P Burt
    Department of Pharmacology, University College London
    Br J Pharmacol 115:467-75. 1995
    ....
  81. ncbi Clonidine and a novel clonidine analog AL-12 cause sympathoinhibition in spontaneously hypertensive and diabetic spontaneously hypertensive rats
    M I A Lazahari
    School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia
    Methods Find Exp Clin Pharmacol 30:193-9. 2008
    ..05) pressure response in the control group. The data obtained suggest that clonidine and AL-12 act possibly via vascular alpha1 and alpha2 adrenoceptors present at both pre- and postsynaptic locations...
  82. ncbi Alpha1A- and alpha1D-adrenoceptors are the major functional subtypes of renal alpha1-adrenoceptors in streptozotocin-induced diabetic and normal Sprague-Dawley rats
    M A Sattar
    School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia
    Auton Autacoid Pharmacol 28:1-10. 2008
    ..A possible minor contribution of prejunctional alpha-adrenoceptor subtype has also been suggested in either experimental group, particularly possible functional involvement of alpha(1B)-adrenoceptor subtypes in non-diabetic SD rats...
  83. ncbi Noradrenaline modulates neuronal responses to GABA in vestibular nuclei
    M Di Mauro
    Department of Physiological Sciences, University of Catania, Viale Andrea Doria 6, Catania, Italy
    Neuroscience 153:1320-31. 2008
    ....
  84. ncbi Expressions and mechanical functions of alpha1-adrenoceptor subtypes in hamster ureter
    Yoshitaka Tomiyama
    Pharmacology Research and Development, Kissei Pharmaceutical Co Ltd, 4365 1, Kashiwabara, Hotaka, Azumino, Nagano 399 8304, Japan
    Eur J Pharmacol 573:201-5. 2007
    ..If these findings hold true for humans, alpha(1A)-adrenoceptor antagonists could become useful medication for stone passage in urolithiasis patients...
  85. ncbi Alpha2 adrenergic receptors and the central control of breathing in the cane toad, Bufo marinus
    J E Rives
    Department of Biology, University of Texas at Arlington, 501 Nedderman Drive, Box 19498, Arlington, TX 76019, USA
    Respir Physiol 125:213-23. 2001
    ..Norepinephrine had no effect on either cardiovascular or respiratory variables. Thus, it appears that an alpha2 adrenergic mechanism is involved in the central control of respiration in this lower vertebrate...
  86. ncbi Existence of alpha(1A)- and alpha(1B)-adrenoceptor subtypes in canine mandibular alveolar arteries
    Y Taguchi
    Department of Pharmacology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan
    Clin Exp Pharmacol Physiol 28:716-20. 2001
    ....
  87. pmc Clonidine-induced nitric oxide-dependent vasorelaxation mediated by endothelial alpha(2)-adrenoceptor activation
    X F Figueroa
    , , , , Santiago, Chile
    Br J Pharmacol 134:957-68. 2001
    ....
  88. ncbi Clonidine inhibits the canine external carotid vasodilatation to capsaicin by alpha2A/2C-adrenoceptors
    Luisa R Jiménez-Mena
    Departamento de Farmacobiologia, Cinvestav Coapa, Czda de los Tenorios 235, Col Granjas Coapa, Deleg Tlalpan, C P 14330, Mexico DF, Mexico
    Eur J Pharmacol 543:68-76. 2006
    ....
  89. ncbi Norepinephrine induces apoptosis in skin melanophores by attenuating cAMP-PKA signals via alpha2-adrenoceptors in the medaka, Oryzias latipes
    N Uchida-Oka
    Department of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Chiba, Japan
    Pigment Cell Res 14:356-61. 2001
    ..These results suggest that NE induces apoptosis in melanophores by attenuating cAMP-PKA signaling via alpha2-adrenoceptors...
  90. pmc Pathological role of a constitutively active population of alpha(1D)-adrenoceptors in arteries of spontaneously hypertensive rats
    Regina Gisbert
    Departamento de Farmacologia, Facultad de Farmacia, Universitat de Valencia, Spain
    Br J Pharmacol 135:206-16. 2002
    ..This change was not observed in prehypertensive or captopril treated animals...
  91. ncbi Modulatory role of a constitutively active population of alpha(1D)-adrenoceptors in conductance arteries
    Khalid Ziani
    Departamento de Farmacologia, Facultad de Farmacia, Universitat de Valencia, 46100 Burjassot, Valencia, Spain
    Am J Physiol Heart Circ Physiol 282:H475-81. 2002
    ..This subtype prevents abrupt changes in iliac and proximal mesenteric artery caliber when the agonist disappears, and this modulatory role is evidenced by the slower decay in the response to norepinephrine after removal...
  92. ncbi Noradrenergic modulation of serotonin release in rat dorsal and median raphé nuclei via alpha(1) and alpha(2A) adrenoceptors
    S E Hopwood
    Neurotransmission Laboratory, Academic Department of Anaesthesia and Intensive Care, St Bartholomew's and the Royal London School of Medicine and Dentistry, Alexandra Wing, Royal London Hospital, Whitechapel, London E1 1BB, UK
    Neuropharmacology 41:433-42. 2001
    ....
  93. ncbi Effect of repeated treatment with tianeptine and fluoxetine on the central alpha(1)-adrenergic system
    Z Rogoz
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Neuropharmacology 41:360-8. 2001
    ..On the other hand, FLU did not affect any behavioural and biochemical changes in this system...
  94. ncbi The contribution of alpha-1 and alpha-2 adrenoceptors in peripheral imidazoline and adrenoceptor agonist-induced nociception
    Ahmet Dogrul
    Gulhane Military Medical Academy, Faculty of Medicine, Department of Medical Pharmacology, Ankara, Turkey
    Anesth Analg 103:471-7, table of contents. 2006
    ..5 mg/kg IP). Our results suggest that local thermal hyperalgesic effects of noradrenaline and phenylephrine are linked to alpha-1 AR and the peripheral antinociceptive action of clonidine and agmatine are linked to alpha-2 AR...
  95. ncbi Alpha1L-adrenoceptors mediate contractions of the isolated mouse prostate
    Katherine T Gray
    Prostate Research Co operative, Victorian College of Pharmacy, Monash University, 381 Royal Parade, Parkville, Victoria, 3052, Australia
    Eur J Pharmacol 540:155-61. 2006
    ....
  96. ncbi The alpha(1A)-adrenoceptor subtype mediates contraction in rat femoral resistance arteries
    Y P Jarajapu
    Vascular Assessment Group, School of Biological and Biomedical Sciences, Glasgow Caledonian University, Cowcaddens Road, Glasgow G4 0BA, Scotland, UK
    Eur J Pharmacol 422:127-35. 2001
    ..These results suggest alpha(1A)-adrenoceptors mediate contractile responses to noradrenaline in rat femoral resistance arteries...
  97. ncbi Evidence against alpha-adrenoceptors mediating relaxation in rat thoracic aortae: alpha-agonists relaxation depends on interaction with alpha-adrenoceptors
    Enrique F Castillo
    Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico, DF, Mexico
    Fundam Clin Pharmacol 20:339-49. 2006
    ....
  98. ncbi Characterization of alpha1-adrenoceptor-mediated contraction in the mouse thoracic aorta
    Y Yamamoto
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Miyama, Funabashi, 274-8510, Chiba, Japan
    Eur J Pharmacol 424:131-40. 2001
    ..These results suggest that the alpha(1D)-adrenoceptor subtype exists, and that the full agonists and the partial agonists evoke the contraction mediated through the alpha(1D)-adrenoceptor in mouse thoracic aorta...
  99. pmc MMP-2 induced vein relaxation via inhibition of [Ca2+]e-dependent mechanisms of venous smooth muscle contraction. Role of RGD peptides
    Joseph D Raffetto
    Division of Vascular Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Surg Res 159:755-64. 2010
    ..We tested whether MMP-2 induced venous relaxation involves inhibition of the Ca(2+) mobilization mechanisms of VSM contraction due to generation of Arg-Gly-Asp (RGD)-containing peptides...
  100. pmc Lateral hypothalamic lesions alter baroreceptor-evoked inhibition of rat supraoptic vasopressin neurones
    R Nissen
    Loeb Research Institute, Ottawa Civic Hospital, Ontario, Canada
    J Physiol 470:751-66. 1993
    ..abstract truncated at 400 words)..
  101. ncbi Adrenergic receptors on smooth muscle cells isolated from human penile corpus cavernosum
    P Costa
    Service d Urologie, C H U Gaston Doumergue, Nimes and Faculté de Pharmacie, Montpellier, France
    J Urol 150:859-63. 1993
    ..This model constitutes a new approach to study the potential targets of the adrenergic agents in the erectile tissue...

Research Grants62

  1. SYMPATHETIC FIBER MODULATION OF NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2003
    ....
  2. Neuropeptide Regulation Vasopressin/Oxytocin Secretion
    CELIA SLADEK; Fiscal Year: 2006
    ..Understanding the role of specific neurotransmitters in relaying hemodynamic information to the VP and OT neurons is central to manipulating the system for treatment of pathological conditions. ..
  3. HORMONAL REGULATION OF ENERGY METABOLISM
    Tarun Patel; Fiscal Year: 1991
    ..This latter approach will also demonstrate if hormone (eg. epinephrine) elicited metabolic alterations are secondary to the inotropic effects of the hormones...
  4. STIMULUS PROPERTIES OF COCAINE
    JAMES O DONNELL; Fiscal Year: 1990
    ..Moreover, these results may have clinical relevance for the pharmacological treatment of cocaine abuse...
  5. VASCULAR ALPHA ADRENERGIC RECEPTORS
    R Alexander; Fiscal Year: 1990
    ..The increased understanding of these mechanisms will provide new insight into the physiologic and pathophysiologic mechanisms by which catecholamines control blood pressure normally and in hyypertension...
  6. CONTROL OF RENIN SECRETION
    PAUL CHURCHILL; Fiscal Year: 1993
    ....
  7. MECHANISM OF CENTRALLY-ACTING ANTIHYPERTENSIVE DRUGS
    Jerry Buccafusco; Fiscal Year: 1991
    ....
  8. REGULATION OF VASCULAR ALPHA1--ADRENERGIC RESPONSES
    Wilson Colucci; Fiscal Year: 2000
    ....
  9. NEURAL CONTROL OF RENIN SECRETION
    MARTHA BLAIR; Fiscal Year: 1980
    ..A possible role for renal cholinergic nerves in control of renin release will be evaluated by vagal or renal nerve stimulation, and by renal artery infusion of acetylcholine, before and after intrarenal muscarinic blockade...
  10. Retinal ganglion cell loss in aging mice.
    Thomas Mittag; Fiscal Year: 2007
    ....
  11. REGULATION OF CARDIAC POTASSIUM CHANNEL GENE EXPRESSION
    Koichi Takimoto; Fiscal Year: 2002
    ..x gene expression independently of hypertrophy. Hence, this proposal is to test these possibilities using hypertension animal models and neonatal myocyte cultures. ..
  12. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  13. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  14. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  15. Sleep Disturbance in Menopause
    Robert Freedman; Fiscal Year: 2006
    ..In Study 5, we will determine the effects of elevated sympathetic activation on HFs and sleep using a stimulus that does not, by itself, disrupt sleep (orthostasis). ..
  16. RUPP-PI Program at Yale University
    Lawrence Scahill; Fiscal Year: 2006
    ..Furthermore, this five-site network has established reliability on several measures that are relevant to the conduct of clinical trials in children with PDD. ..
  17. Psychopharmacology of Autism and related Disorders
    David Posey; Fiscal Year: 2007
    ..Towards the later years of the award, the candidate will have performed additional studies and applied for independent research funding. ..
  18. Behavior Therapy for Adults with Tourette Syndrome
    Lawrence Scahill; Fiscal Year: 2009
    ..The Informatics group at Yale University will provide data management services. ..
  19. ADHD Phenotype Network: Animal Model to Clinical Trial
    Floyd Sallee; Fiscal Year: 2004
    ..abstract_text> ..
  20. CLONIDINE IN ADHD
    Floyd Sallee; Fiscal Year: 2005
    ..abstract_text> ..
  21. Anger Control Training for Youth with Tourette Syndrome
    Larry Scahill; Fiscal Year: 2005
    ..This design will permit demonstration of a clinically relevant effect size for anger control training in adolescents with TS. ..
  22. BEHAVIORAL TREATMENT OF MENOPAUSAL HOT FLASHES
    Robert Freedman; Fiscal Year: 2009
    ....
  23. Norepinephrine and Nerve Growth Factor in Heart Failure
    Chang Seng Liang; Fiscal Year: 2004
    ..Our research will not only elucidate the mechanisms responsible for noradrenergic nerve ending dysfunction, but also provide a potentially useful new modality for the treatment of heart failure. ..
  24. Characterization of Toxicity with Spinal Opiates
    Tony L Yaksh; Fiscal Year: 2010
    ..The present studies aim to define the mechanisms of granuloma formation and point to specific methods to prevent granuloma formation, which will increase the utility and reduce the risks of this important pain therapy. ..
  25. Course of psychopathology in female youth: Analysis with extant longitudinal data
    Joseph Biederman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  26. Pain Mechanisms and the Development of Analgesics
    Tony Yaksh; Fiscal Year: 2006
    ..g. COX2 inhibitors, GABApentin, ziconotide) and failures (NK1 antagonist). [unreadable] [unreadable] [unreadable]..
  27. Adult Outcome of Attention Deficit Hyperactivity Disorder
    Joseph Biederman; Fiscal Year: 2007
    ..For these reasons, we expect the proposed work to clarify the course and outcome of ADHD. ..
  28. Aging and Sympathetic Vasoconstriction: Rest vs Exercise
    FRANK DINENNO; Fiscal Year: 2007
    ..abstract_text> ..
  29. Behavioral state development in infants
    Mark Blumberg; Fiscal Year: 2009
    ..abstract_text> ..
  30. Aging, Endothelial Dysfunction, and Impaired Vascular Control During Exercise
    FRANK DINENNO; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  31. Juvenile Bipolar Disorder and Substance Abuse
    Timothy E Wilens; Fiscal Year: 2010
    ..Since BPD is identifiable and treatable, findings from the four-year follow-up will provide valuable information to formulate prevention and early intervention strategies. ..
  32. Aging, Endothelial Dysfunction, and ATP-mediated Vasodilation in Humans
    FRANK DINENNO; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. Substance Abuse in ADHD Girls
    Timothy Wilens; Fiscal Year: 2006
    ..Thus, the research, approach, and goals of this R01 application are consistent with those underscored in the PA and by the Institute of Medicine as being of the highest research priority. ..
  34. ANESTHESIA AND COCAINE INDUCED CNS EXCITOTOXICITY
    ROBERT WHITTINGTON; Fiscal Year: 2003
    ..This award will allow me to obtain the investigational skills and knowledge base that will enable me to develop into a clinician-scientist and independent investigator in anesthesiology and neuroscience research. ..
  35. LONGITUDINAL FOLLOW UP OF ADHD GIRLS AND THEIR SIBLINGS
    Joseph Biederman; Fiscal Year: 2002
    ....
  36. AGING AND ALPHA-ADRENERGIC CONTROL OF MUSCLE BLOOD FLOW
    FRANK DINENNO; Fiscal Year: 2002
    ..These experiments will provide important new information about sympathetic control of blood flow to resting and contracting skeletal muscle in aging humans. ..
  37. Pharmacogenetics in Tourette Syndrom
    Harvey Singer; Fiscal Year: 2004
    ..The identification of genetic polymorphisms that are associated with clinical disease or treatment success, has obvious benefits. ..
  38. PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDS
    Tony Yaksh; Fiscal Year: 2005
    ....
  39. Vascular tone and blood pressure control during exercise
    John Buckwalter; Fiscal Year: 2005
    ..This is an issue of fundamental importance that may have important implications for individuals with peripheral vascular disease. ..
  40. CARDIOVASCULAR CONCOMITANTS OF ULTRASONIC VOCALIZATIONS
    Mark Blumberg; Fiscal Year: 2002
    ..Through these approaches, an integrated view of the varied mechanisms by which infant and adult mammals regulate cardiovascular function during physiological and behavioral challenges will emerge. ..
  41. LONG TERM DRUG ABUSE IN ADHD
    Timothy Wilens; Fiscal Year: 2002
    ..abstract_text> ..
  42. Spinal Galanin and its Receptors in Pain Processing
    Tony Yaksh; Fiscal Year: 2005
    ..We believe the outcome of these studies will provide direct evidence for the role played by this spinal peptidergic system in pain and point to the development of novel anti-hyperpathic agents. ..
  43. NEUROBIOLOGY OF PAIN
    Tony Yaksh; Fiscal Year: 2005
    ..The complexity of the problems and the diversity of the training approaches emphasize that the training received by these fellows will provide a broad base of knowledge relevant to wide areas of neurobiology. ..
  44. Collaborative Pediatric Bipolar Disorder Conference
    Joseph Biederman; Fiscal Year: 2007
    ..While the proposed conference does not intend to solve all outstanding problems associated with pediatric bipolar disorder, it will provide a forum to begin formulating a solution. ..
  45. PREVENTION OF CIGARETTE SMOKING IN ADHD YOUTH
    Joseph Biederman; Fiscal Year: 2001
    ..Since there are estimated to be 3.5 million children with ADHD and 20% have been shown to be smokers, targeting this group could potentially impact 700,000 children and adolescents. ..
  46. Prion Transport Across the Blood-Brain Barrier
    William Banks; Fiscal Year: 2009
    ..To cause disease, prions must cross the blood-brain barrier to enter the brain. We will determine how prions cross the BBB. Knowing how prions enter the brain should lead to strategies on how to prevent prion diseases. ..
  47. Effect of Biomechanical Force Exposure on Cognition & Brain Activation in Student
    Thomas McAllister; Fiscal Year: 2009
    ..Impact parameters will be directly measured using helmet-based accelerometer units. ..
  48. Using Social Risk to Guide Coronary Heart Disease (CHD) Preventive Treatment
    Kevin Fiscella; Fiscal Year: 2009
    ..Implementation of such a global risk tool could ultimately help justify implementation of more intensive behavioral interventions focusing on diet, exercise, smoking cessation and medication adherence for those at highest social risk. ..
  49. Opioid-Dependent Adolescents: A Detoxification Study
    Lisa Marsch; Fiscal Year: 2002
    ..As the number of opioid-dependent adolescents continues to dramatically increase, identifying effective treatments to meet the unique needs of this population is critical. ..
  50. Glucocorticoids and Apoptosis of Cerebellar Neural Progenitor Cells
    Nuri Farber; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  51. SHORT-TERM RESEARCH TRAINING FOR MINORITY STUDENTS
    Charles Wood; Fiscal Year: 2008
    ..The emphasis of this training program in the next five years will be to significantly expand the students' horizons and to recruit students into basic biomedical science. ..
  52. Models of Antipsychotic Prophylaxis for Schizophrenia
    Susan Powell; Fiscal Year: 2005
    ..3. To assess the effects of prophylactic antipsychotic treatment on neonatal ventral hippocampal lesion induced behavioral deficits. ..
  53. Pain Assessment in Cognitively Impaired Children
    Shobha Malviya; Fiscal Year: 2005
    ..A reliable and valid pain assessment tool is critical to facilitate our future study of pain management strategies in these children. ..
  54. CIC-3 chloride ion channels in vascular smooth muscle
    Fred Lamb; Fiscal Year: 2007
    ..Careful analysis of the physiological defects in Clcn3-/- mice will yield important insight into cellular ROS metabolism and the link between ROS and high blood pressure. ..
  55. Cellular Mechanisms in Cocaine Self-Administration
    CARLOS PALADINI; Fiscal Year: 2007
    ..Recordings from yoked-controls will also be used. Intracranial microinjections will also be used to determine whether the mGluR response can control cocaine self-administration. ..
  56. Animal Models of Childhood and Adolescent Depression
    David Bylund; Fiscal Year: 2005
    ..abstract_text> ..
  57. Imaging Unconditioned Fear
    Jean King; Fiscal Year: 2006
    ..Since fear experience by all animals, these studies may expand our understanding of anxiety and phobias in general. ..
  58. TESTING THE VALIDITY OF ADULT ATTENTION DEFICIT DISORDER
    Stephen Faraone; Fiscal Year: 2002
    ..Thus, if founded, we expect that the proposed work will lead to a program of research that can both clarify the nosological complexities of adult ADHD and clarify the nature of genes that are risk factors for the disorder. ..
  59. International Multi-Center ADHD Genetics Project
    Stephen Faraone; Fiscal Year: 2007
    ..abstract_text> ..