adrenergic antagonists


Summary: Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.

Top Publications

  1. pmc Pharmacokinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate
    Paul A Moore
    Department of Anesthesiology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Anesth Prog 55:40-8. 2008
  2. ncbi Adrenergic antagonists reduce lactic acidosis in response to hemorrhagic shock
    F A Luchette
    Division of Trauma and Critical Care, University of Cincinnati College of Medicine, Ohio, USA
    J Trauma 46:873-80. 1999
  3. ncbi Neuroprotective effect of nipradilol on axotomized rat retinal ganglion cells
    Toru Nakazawa
    Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan
    Curr Eye Res 24:114-22. 2002
  4. ncbi The effects of combined versus selective adrenergic blockade on left ventricular and systemic hemodynamics, myocardial substrate preference, and regional perfusion in conscious dogs with dilated cardiomyopathy
    Lazaros A Nikolaidis
    Department of Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    J Am Coll Cardiol 47:1871-81. 2006
  5. ncbi Effects of adrenoceptor antagonists on the cutaneous blood flow increase response to sympathetic nerve stimulation in rats with persistent inflammation
    Tomoko Koeda
    Department of Neural Regulation, Research Institute of Environmental Medicine, Nagoya University, Furo cho, Chukusa ku, Nagoya, 464 8601 Japan
    Jpn J Physiol 52:521-30. 2002
  6. ncbi Nonhypotensive autonomic agents in veterinary ophthalmology
    Gia Klauss
    Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, 379 East Campus Drive, Columbia, MO 65211, USA
    Vet Clin North Am Small Anim Pract 34:777-800. 2004
  7. ncbi Sympathetic innervation of mammary glands mediates suckling-induced reflex inhibition of milk yield in rats
    T Morales
    , , Campus UNAM, Apdo. Postal 1-1140 76230 Juriquilla, , Qro, Mexico
    Physiol Behav 74:37-43. 2001
  8. ncbi Altered melatonin production in TGR(mREN2)27 rats: on the regulation by adrenergic agonists, antagonists and angiotensin II in cultured pinealocytes
    H Enzminger
    Institute of Pharmacology and Toxicology Mannheim, Ruprecht-Karls-University of Heidelberg, Germany
    J Pineal Res 31:256-63. 2001
  9. ncbi Cardiac remodeling after long term norepinephrine treatment in rats
    W Briest
    Carl Ludwig Institute of Physiology, University of Leipzig, Liebigstr 27, D 04103, Leipzig, Germany
    Cardiovasc Res 52:265-73. 2001
  10. ncbi The effects of epiphyseal peptides on the release of immunoglobulins in Peyer's patches in rats in vitro
    O A Zimina
    Department of General Physiology, St Petersburg State University, 7 9 Universitetskaya Bank, 199034 St Petersburg, Russia
    Neurosci Behav Physiol 33:893-7. 2003

Detail Information

Publications243 found, 100 shown here

  1. pmc Pharmacokinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate
    Paul A Moore
    Department of Anesthesiology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Anesth Prog 55:40-8. 2008
    ..The phentolamine-induced delay of the lidocaine Tmax likely represents phentolamine's ability to accelerate the systemic absorption of lidocaine from oral tissues into the systemic circulation...
  2. ncbi Adrenergic antagonists reduce lactic acidosis in response to hemorrhagic shock
    F A Luchette
    Division of Trauma and Critical Care, University of Cincinnati College of Medicine, Ohio, USA
    J Trauma 46:873-80. 1999
    ..In this study, we tested whether adrenergic antagonists can block lactate production during shock.
  3. ncbi Neuroprotective effect of nipradilol on axotomized rat retinal ganglion cells
    Toru Nakazawa
    Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan
    Curr Eye Res 24:114-22. 2002
    ..To determine whether nipradilol, a new anti-glaucoma drug, can protect retinal ganglion cells (RGCs) from secondary cell death caused by transection of the optic nerve (ON)...
  4. ncbi The effects of combined versus selective adrenergic blockade on left ventricular and systemic hemodynamics, myocardial substrate preference, and regional perfusion in conscious dogs with dilated cardiomyopathy
    Lazaros A Nikolaidis
    Department of Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    J Am Coll Cardiol 47:1871-81. 2006
  5. ncbi Effects of adrenoceptor antagonists on the cutaneous blood flow increase response to sympathetic nerve stimulation in rats with persistent inflammation
    Tomoko Koeda
    Department of Neural Regulation, Research Institute of Environmental Medicine, Nagoya University, Furo cho, Chukusa ku, Nagoya, 464 8601 Japan
    Jpn J Physiol 52:521-30. 2002
    ..In addition, the beta-adrenoceptor antagonist had no effects on both responses. These results suggest that the BF-increase response to SS involves, additionally to NA, a non-adrenergic mechanism...
  6. ncbi Nonhypotensive autonomic agents in veterinary ophthalmology
    Gia Klauss
    Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, 379 East Campus Drive, Columbia, MO 65211, USA
    Vet Clin North Am Small Anim Pract 34:777-800. 2004
    ..The cholinergic and adrenergic agents discussed in this article are commonly employed to facilitate routine ophthalmic examination, in the diagnosis of autonomic dysfunction, and in the treatment of a variety of ocular diseases...
  7. ncbi Sympathetic innervation of mammary glands mediates suckling-induced reflex inhibition of milk yield in rats
    T Morales
    , , Campus UNAM, Apdo. Postal 1-1140 76230 Juriquilla, , Qro, Mexico
    Physiol Behav 74:37-43. 2001
    ..Together, these results indicate that suckling inhibits ME through the reflex activation of neurally mediated central beta-adrenergic mechanisms, and that these effects, in turn, can be regulated by ductal mechanoreceptor activation...
  8. ncbi Altered melatonin production in TGR(mREN2)27 rats: on the regulation by adrenergic agonists, antagonists and angiotensin II in cultured pinealocytes
    H Enzminger
    Institute of Pharmacology and Toxicology Mannheim, Ruprecht-Karls-University of Heidelberg, Germany
    J Pineal Res 31:256-63. 2001
    ..The renin-angiotensin system was not directly involved in the regulation of melatonin synthesis by rat pinealocytes in vitro...
  9. ncbi Cardiac remodeling after long term norepinephrine treatment in rats
    W Briest
    Carl Ludwig Institute of Physiology, University of Leipzig, Liebigstr 27, D 04103, Leipzig, Germany
    Cardiovasc Res 52:265-73. 2001
    ..In this study we have tested the hypothesis that degradation of collagen by matrix metalloproteinase 2 (MMP-2) precedes the deposition of extracellular matrix (ECM) after long term norepinephrine (NE) treatment...
  10. ncbi The effects of epiphyseal peptides on the release of immunoglobulins in Peyer's patches in rats in vitro
    O A Zimina
    Department of General Physiology, St Petersburg State University, 7 9 Universitetskaya Bank, 199034 St Petersburg, Russia
    Neurosci Behav Physiol 33:893-7. 2003
  11. ncbi [Role of adrenoreceptors in the effect of thyroliberin on lymphatic vessels]
    T V Lelekova
    Lomonossov State University, 119899, Moscow, Vorobievy Gory, Russia
    Ross Fiziol Zh Im I M Sechenova 90:32-9. 2004
    ..As it occurred, desympathization hindered development of stimulating action of TRH. Thus, the efficiency of TRH as a stimulator of LV is connected with activation of adrenergic mechanisms...
  12. ncbi Molecular cloning and functional expression of the guinea pig alpha(1a)-adrenoceptor
    C Gonzalez-Espinosa
    Departamento de Biologia Celular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Apartado Postal 70 248, Mexico, D F 04510, Mexico
    Eur J Pharmacol 426:147-55. 2001
    ..The receptor was functional, as evidenced by an epinephrine-increased production of [(3)H]inositol phosphates that was blocked by prazosin...
  13. ncbi High concentrations of adrenergic antagonists prolong sciatic nerve blockade by tetrodotoxin
    D S Kohane
    Department of Anesthesia, Children's Hospital, Boston, Massachusetts, USA
    Acta Anaesthesiol Scand 45:899-905. 2001
    BACKGROUND: Millimolar-range concentrations of some adrenergic antagonists have been shown to have local anesthetic-like properties, and to stimulate GTPase activity in vitro...
  14. pmc Disturbance of the prejunctional modulation of cholinergic neurotransmission during chronic granulomatous inflammation of the mouse ileum
    J G de Man
    Division of Gastroenterology, Faculty of Medical and Pharmaceutical Sciences, University of Antwerp (UIA, Universiteitsplein 1, B-2610 Wilrijk, Belgium
    Br J Pharmacol 133:695-707. 2001
    ..Such a disturbance of cholinergic nerve activity may contribute to the motility disturbances that are often observed during chronic intestinal diseases in humans...
  15. ncbi G-protein coupled receptors: SAR analyses of neurotransmitters and antagonists
    C L Kuo
    School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
    J Clin Pharm Ther 29:279-98. 2004
    ..Selective agonists and antagonists of each receptor subtype can have specific useful therapeutic applications. For understanding the molecular mechanisms of action, an inductive method of analysis is useful...
  16. ncbi Effects of adrenergic agonists and antagonists on tetrodotoxin-induced nerve block
    D S Kohane
    Department of Anesthesia, Children's Hospital, Pain Treatment Service, 333 Longwood Ave, Boston, MA 02115, USA
    Reg Anesth Pain Med 26:239-45. 2001
    ..b>Adrenergic antagonists did not inhibit the prolongation of TTX block by agonists when injected 3 or 6 hours after the initial ..
  17. ncbi Taurine prevents streptozotocin impairment of hormone-stimulated glucose uptake in rat adipocytes
    M Alessandra Colivicchi
    Department of Preclinical and Clinical Pharmacology Mario Aiazzi Mancini, University of Florence, Viale G Pieraccini 6, Florence 50139, Italy
    Eur J Pharmacol 495:209-15. 2004
    ..Because insulin and adrenergic activations of glucose transport by adipocytes are coupled to different signalling pathways, it is unlikely that these effects of taurine are related to these disparate postreceptor mechanisms...
  18. ncbi Noradrenaline-induced cation currents in isolated rat paratracheal ganglion neurons
    Mari Umezu
    Department of Cellular and System Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Brain Res 1023:74-82. 2004
    ..The cationic channels activated by NA play an important physiological role in neuronal membrane depolarization in rat paratracheal ganglia...
  19. ncbi Regarding the unitary theory of agonist and antagonist action at presynaptic adrenoceptors
    S Kalsner
    Department of Physiology and Pharmacology, CUNY Medical School/Sophie Davis School of Biomedical Education, City College of New York, New York City, NY 10031, USA
    J Auton Pharmacol 21:145-9. 2001
    ..5 It is concluded that the unitary hypothesis that asserts that antagonist enhancement of transmitter release and its blockade of noradrenaline induced inhibition are manifestations of a unitary event are not supportable...
  20. ncbi Chronic cardiovascular and renal actions of leptin: role of adrenergic activity
    Megan Carlyle
    Department of Physiology and Biophysics and Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 39:496-501. 2002
    ..0 microg/kg/min) for 7 days along with vehicle or adrenergic antagonists, followed by a 7-day recovery period...
  21. ncbi Effects of adrenoceptor agonists and antagonists on morphine-induced Straub tail in mice
    Mohammad Reza Zarrindast
    Department of Pharmacology, Medical School, Tehran University of Medical Sciences, P O Box 13145 784, Tehran, Iran
    Pharmacol Biochem Behav 72:203-7. 2002
    ..did not alter morphine-induced Straub-tail behavior in mice. In conclusion, activation of alpha2-adrenergic pathways contributes to morphine-induced Straub tail, while alpha1- and beta2-adrenergic may not be involved in this phenomenon...
  22. ncbi Contribution of 5- and 12-lipoxygenase products to mechanical hyperalgesia induced by prostaglandin E(2) and epinephrine in the rat
    O Aley
    NIH Pain Center, University of California, Box 0440, Room C522, 521 Parnassus Ave, San Francisco, CA 94143 0440, USA
    Exp Brain Res 148:482-7. 2003
    ..products of the 5-lipoxygenase and 12-lipoxygenase pathway are involved in this function, and (3). these lipoxygenase products contribute to hyperalgesia at or downstream of protein kinase A and PKCepsilon...
  23. pmc Functional characterization of alpha 1-adrenoceptor subtypes in vascular tissues using different experimental approaches: a comparative study
    Regina Gisbert
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Avda, Vincent Andres Estelles s n 46100, Burjassot, Valencia, Spain
    Br J Pharmacol 138:359-68. 2003
    ..6. The appropriate management of LiCl in IP accumulation studies allowed us to reproduce the different experimental procedures performed in contractile experiments giving more technical possibilities to this methodology...
  24. ncbi Modulatory effect of the adrenergic system upon fibroblast proliferation: participation of beta 3-adrenoceptors
    C Anesini
    Pharmacology Unit, School of Dentistry, University of Buenos Aires, Marcelo T de Alvear 2142 1122, Capitol Federal Buenos Aires, Argentina
    Auton Autacoid Pharmacol 22:177-86. 2002
    ..The mechanism by which ZD 7114 triggers cell proliferation and function, involves the activation of phospholipase C, PKC, calcium/calmodulin and the influx of calcium...
  25. ncbi Dual adrenergic control of in vivo choline levels in the mouse major salivary glands
    S Murai
    Department of Pharmacology, School of Dentistry, Iwate Medical University, Morioka 020 8505, Japan
    Auton Autacoid Pharmacol 22:17-27. 2002
  26. ncbi The antinociceptive effect of mirtazapine in mice is mediated through serotonergic, noradrenergic and opioid mechanisms
    Shaul Schreiber
    Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
    Brain Res Bull 58:601-5. 2002
    ..However, further research is needed in order to establish both the exact clinical indications and the effective doses of mirtazapine when prescribed for pain...
  27. ncbi Involvement of catecholamines in the regulation of oocyte maturation in frogs
    Inés Ramos
    Department of Developmental Biology, National Council for Scientific and Technical Research, National University of Tucuman, Argentina
    Zygote 10:271-81. 2002
    ..Nevertheless, pretreatment of follicles with adrenaline caused a significant inhibition in progesterone-induced nuclear maturation even though this effect was markedly weaker when using noradrenaline...
  28. ncbi Salivary secretion of immunoglobulin A by submandibular glands in response to autonomimetic infusions in anaesthetised rats
    G B Proctor
    Salivary Research Group, Unit, Guy s, King s and St Thomas School of Dentistry, The Rayne Institute, 123 Coldharbour Lane, London SE5 9NU, UK
    J Neuroimmunol 136:17-24. 2003
    ..The secretion of fluid or proteins but not IgA was increased with frequency of nerve stimulation and dose of methacholine (cholinergic), isoprenaline (beta-adrenergic) or phenylephrine (alpha-adrenergic)...
  29. ncbi Mitochondrial respiration in muscle and liver from cold-acclimated hypothyroid rats
    Angel A Zaninovich
    Hospital de Clinicas, Nuclear Medicine Center, Av Cordoba 2351, 1120 Buenos Aires, Argentina
    J Appl Physiol (1985) 95:1584-90. 2003
    ..After thyroid ablation, cold-induced nonshivering thermogenesis replaced 3,5,3'-triiodothyronine-induced thermogenesis, and normal body temperature was maintained...
  30. ncbi Influence of agonist efficacy and receptor phosphorylation on antagonist affinity measurements: differences between second messenger and reporter gene responses
    Jillian G Baker
    Institute of Cell Signaling, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Mol Pharmacol 64:679-88. 2003
  31. ncbi [Effect of ozone exposure on contractile activity and chemoreactivity of uterus horns longitudinal muscles of nonpregnant rats]
    E N Sizova
    Viatka State Humanitarian University, 111 Lenin St, 610002, Kirov, Russia
    Ross Fiziol Zh Im I M Sechenova 89:427-35. 2003
  32. ncbi Role of noradrenergic fibers of the preoptic area in regulating sleep
    Velayudhan Mohan Kumar
    Department of Physiology, All India Institute of Medical Sciences, 110029 New Delhi, India
    J Chem Neuroanat 26:87-93. 2003
    ..Thus, the available evidence shows that the NE fibers in the POA are involved in the induction of sleep...
  33. ncbi Effect of inhibition of nitric oxide synthase on the vasopressor response to ephedrine
    Paul A Dabisch
    Department of Pharmacology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Can J Physiol Pharmacol 81:966-71. 2003
    ..The results demonstrate that the vascular response to ephedrine in the rat is modulated by NO and that NO production in response to ephedrine may be secondary to beta 2-receptor stimulation...
  34. ncbi Role of serotonergic and noradrenergic systems in a model of visceral pain
    I Korzeniewska-Rybicka
    Department of Experimental and Clinical Pharmacology, Warsaw Medical University, Warszawa, Poland
    Pol J Pharmacol 53:475-80. 2001
    ..On the other hand, adrenergic alpha1 and beta1 receptors facilitate the behavioral effects of the irritant agent...
  35. ncbi The role of the sympathetic nervous system in controlling bone metabolism
    Akifumi Togari
    Department of Pharmacology, School of Dentistry, Aichi Gakuin University, Nagoya 464 8650, Japan
    Expert Opin Ther Targets 9:931-40. 2005
    ..To confirm this important new therapeutic avenue to prevent bone loss, the relationship between the pharmacological effectiveness of beta-blockers and the pathogenesis of osteoporosis must be explored in detail...
  36. ncbi Noradrenaline and dopamine regulation of prolactin secretion in sheep: role in prolactin homeostasis but not photoperiodism
    G A Lincoln
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh, UK
    J Neuroendocrinol 14:36-44. 2002
    ..In contrast, the lack of responses to the antagonists in the HPD rams, support the view that neither DA, nor NA, mediate the photoperiodic control of PRL secretion...
  37. ncbi The role of norepinephrine in epilepsy: from the bench to the bedside
    Filippo S Giorgi
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma 55, 56100 Pisa, Italy
    Neurosci Biobehav Rev 28:507-24. 2004
    ..Finally, recent data demonstrate that NE loss increases neuronal damage following focally induced limbic status epilepticus, confirming a protective effect of brain NE, which has already been shown in other neurological disorders...
  38. ncbi Adrenergic modulation of Escherichia coli O157:H7 adherence to the colonic mucosa
    Benedict T Green
    Pharmacology Section, Department of Veterinary and Biomedical Sciences, University of Minnesota, 1988 Fitch Ave, St Paul, Minnesota 55108 6010, USA
    Am J Physiol Gastrointest Liver Physiol 287:G1238-46. 2004
    ..Through interactions with alpha(2)-adrenergic receptors, NE appears to increase EHEC adherence to the colonic mucosa. Changes in sympathetic neural outflow may alter intestinal susceptibility to infection...
  39. ncbi [NO synthase activity in epitheliocytes of the rat bronchi following inhalation administration of adrenergic agonists and guanosine triphosphate]
    E V Eliseeva
    Department of Histology, State Medical University of Vladivostok
    Morfologiia 119:48-51. 2001
    ..NO synthase mediator action on bronchial patency during adrenoagonists and GTP inhalation was demonstrated...
  40. ncbi Effects of spinal analgesics on spinal circulation: the safety standpoint
    Hiroki Iida
    Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Japan
    J Neurosurg Anesthesiol 20:180-7. 2008
    ..This review therefore focuses on the effects on the spinal circulation induced by well-known spinal analgesics employed in the treatment of acute and chronic pain disorders...
  41. ncbi Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder
    J R Strawn
    Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Depress Anxiety 25:260-71. 2008
    ..The utility of these anti-adrenergics in the clinical treatment of PTSD remains to be determined, though it is possible that they may prove to have primary roles in a disorder that is only modestly responsive to antidepressant treatment...
  42. ncbi Memory systems in the chick: regional and temporal control by noradrenaline
    Marie E Gibbs
    Department of Anatomy and Developmental Biology, Monash University, Clayton 3800, Australia
    Brain Res Bull 76:170-82. 2008
    ..The memory system of the chick is very similar to that of mammals in terms of brain regions recruited in memory processing and in the ways memory is modulated by noradrenaline...
  43. ncbi Direct neurite-osteoblastic cell communication, as demonstrated by use of an in vitro co-culture system
    Koji Obata
    Department of Pharmacology, School of Dentistry, Aichi Gakuin University, 1 100 Kusumoto cho, Chikusa ku, Nagoya 464 8650, Japan
    FEBS Lett 581:5917-22. 2007
    ..These results demonstrate that osteoblastic activation occurred as a direct response to neuronal activation, which activation was mediated by alpha1-ARs in the osteoblastic cells...
  44. pmc Testosterone protects rat hearts against ischaemic insults by enhancing the effects of alpha(1)-adrenoceptor stimulation
    S Tsang
    Department of Physiology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Br J Pharmacol 153:693-709. 2008
    ..Androgen receptors are present in the heart, and testosterone upregulates gene expression of cardiac beta(1)-adrenoceptors. We hypothesize that testosterone may confer cardioprotection by interacting with adrenoceptors...
  45. ncbi Reversal of cardiac remodeling by modulation of adrenergic receptors: a new frontier in heart failure
    Cinzia Perrino
    Division of Cardiology, Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy
    Curr Opin Cardiol 22:443-9. 2007
    ..Heart failure is a common clinical syndrome, and despite intensive medical therapy it remains a leading cause of global morbidity and mortality. Pathological stimuli promote a general remodeling process in the heart...
  46. ncbi A2A adenosine-receptor-mediated facilitation of noradrenaline release in rat tail artery involves protein kinase C activation and betagamma subunits formed after alpha2-adrenoceptor activation
    Paula Fresco
    Servico de Farmacologia, REQUIMTE FARMA, Faculdade de Farmacia, Universidade do Porto, Rua Anibal Cunha, 164, P 4050 047 Porto, Portugal
    Neurochem Int 51:47-56. 2007
  47. pmc Amnesia produced by altered release of neurotransmitters after intraamygdala injections of a protein synthesis inhibitor
    Clinton E Canal
    Neuroscience Program, Department of Animal Sciences, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    Proc Natl Acad Sci U S A 104:12500-5. 2007
    ..These findings suggest that altered release of neurotransmitters may mediate amnesia produced by anisomycin and, further, raise important questions about the empirical bases for many molecular theories of memory formation...
  48. pmc Noradrenergic agonist administration into the central nucleus of the amygdala increases the tail-flick latency in lightly anesthetized rats
    J P Ortiz
    Department of Neurological Surgery, Oregon Health and Science University, Mail code CH8N, 3303 Southwest Bond Avenue, Portland, OR 97239, USA
    Neuroscience 148:737-43. 2007
    ..These results demonstrate that anatomically and pharmacologically specific activation of alpha(2)-receptors in the CeA in lightly anesthetized rats results in behaviorally measurable antinociception...
  49. ncbi Differential regulation on human skin fibroblast by alpha1 adrenergic receptor subtypes
    Leonor Sterin-Borda
    Pharmacology Unit, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina
    Biochem Pharmacol 74:1401-12. 2007
    ..Results suggest that the expression of alpha1-AR subtypes on human skin fibroblast may differentially activate signaling pathways that modulate physiological response of the cells...
  50. ncbi Adrenergic responses of rat colonic muscularis mucosae
    William H Percy
    Division of Basic Biomedical Sciences, Sanford School of Medicine, The University of South Dakota, Vermillion, SD 57069 2390, USA
    J Pharm Pharmacol 60:1097-103. 2008
  51. ncbi Effects of catecholamines on the intramedullary pressure in the femur in rats with prednisolone-induced osteoporosis
    Ilona Kaczmarczyk-Sedlak
    Department of Pharmacology, Medical University of Silesia, Jagiellonska 4, PL 41 200 Sosnowiec, Poland
    Pharmacol Rep 58:540-50. 2006
    ..In addition, a disordered effect of catecholamines on intramedullary pressure of osteoporotic bone was observed...
  52. ncbi Roles of adrenergic and cholinergic stimulation in spontaneous atrial fibrillation in dogs
    Oleg F Sharifov
    Laboratory of Heart Electrophysiology, Cardiology Research Center, Moscow, Russia
    J Am Coll Cardiol 43:483-90. 2004
    ..We studied the effects of beta-adrenergic and cholinergic stimulation and blockade on spontaneous atrial fibrillation (AF) in the intact dog heart...
  53. ncbi Regulation of postburn ischemia by alpha- and beta-adrenoceptor subtypes
    Jean Cassuto
    Department of Anaesthesia and Intensive Care and Institution of Surgical Specialties, Sahlgrenska University Hospital, S 43180 Mölndal, Sweden
    Burns 31:131-7. 2005
    ..In full-thickness burns, activation of alpha(2)-receptors was shown to significantly impair skin circulation, raising a flag of warning for the use of clonidine to treat pain in burn patients...
  54. ncbi Conceptually driven pharmacologic approaches to acute trauma
    Roger K Pitman
    Massachusetts General Hospital, Charlestown, MA 02129, USA
    CNS Spectr 10:99-106. 2005
    ..with alpha2-adrenergic agonists or opioids, or blocking post-synaptic norepinephrine receptors with beta-adrenergic antagonists such as propranolol, reduces hormonally enhanced memories and fear conditioning...
  55. ncbi The antinociceptive effect of zolpidem and zopiclone in mice
    Chaim G Pick
    Department of Anatomy and Anthropology, Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, 69978, Israel
    Pharmacol Biochem Behav 81:417-23. 2005
    ..e. elderly) and for possible drug-drug interactions, in order to minimize possible hazards and maximize clinical beneficial effects of its use for sleep...
  56. ncbi Carvedilol mitigates adverse effects of epinephrine during cardiopulmonary resuscitation
    Lei Huang
    The Institute of Critical Care Medicine, Palm Springs, CA, USA
    J Cardiovasc Pharmacol Ther 10:113-20. 2005
    ..Because carvedilol is both a nonselective beta- and alpha1-selective adrenergic receptor-blocking agent, we hypothesized that pretreatment with carvedilol would convert the actions of epinephrine to that of a selective alpha2-agonist...
  57. ncbi Adrenergic origin of very low-frequency blood pressure oscillations in the unanesthetized rat
    Alberto Radaelli
    Divisione de Riabilitazione Cardiologica, Ospedale San Gerardo, Monza, Italy
    Am J Physiol Heart Circ Physiol 290:H357-64. 2006
    ..These fluctuations may have (patho)physiological relevance under conditions of disrupted circulatory homeostasis...
  58. ncbi Carvedilol action is dependent on endogenous production of nitric oxide
    Ricardo A Afonso
    Department of Biochemistry, Faculty of Medical Sciences, Universidade Nova de Lisboa, Campo Mártires da Pátria, Lisboa, Portugal
    Am J Hypertens 19:419-25. 2006
    ..However, its therapeutic actions cannot be fully explained by these mechanisms. In these studies, we tested the hypothesis that carvedilol action is associated with the synthesis/release of nitric oxide (NO)...
  59. ncbi Noradrenergic modulation of working memory and emotional memory in humans
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 188:397-407. 2006
    ..NA dysfunction and abnormalities in arousal-dependent memory functions are evident in a variety of neuropsychiatric illnesses...
  60. ncbi Central venous pressure and mean circulatory filling pressure in the dogfish Squalus acanthias: adrenergic control and role of the pericardium
    Erik Sandblom
    Dept of Zoology, Göteborg Univ, Box 463, Goteborg S 405 30, Sweden
    Am J Physiol Regul Integr Comp Physiol 291:R1465-73. 2006
    ..Thus active changes in venous capacitance have previously been underestimated as an important means of modulating venous return and cardiac performance in this group...
  61. ncbi Monotherapy versus combination drug therapy for the treatment of benign prostatic hyperplasia
    Youlanda T Logan
    Department of Pharmacy Practice, Hampton University School of Pharmacy, Hampton, Virginia 23668, USA
    Am J Geriatr Pharmacother 3:103-14. 2005
    ..Results from the Medical Therapy of Prostatic Symptoms (MTOPS) trial, the largest and longest clinical trial on this topic to date, revisited the role of combination therapy in the treatment of BPH...
  62. pmc Effects of beta-adrenergic receptor antagonists on oxidative stress in purified rat retinal ganglion cells
    Zi Kui Yu
    Department of Ophthalmology, University of Tokyo, Japan
    Mol Vis 13:833-9. 2007
    ..To investigate the effect of beta-adrenergic receptor antagonists against oxidative stress on purified rat retinal ganglion cells (RGCs), timolol, betaxolol, carteolol and nipradilol were included in the present study...
  63. ncbi The role of combination medical therapy in benign prostatic hyperplasia
    K A Greco
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Int J Impot Res 20:S33-43. 2008
    ..Men with overactive bladder and BPH who are not receiving adequate alleviation of symptoms from the first-line alpha(1)-ARAs may benefit from the addition of an anti-muscarinic agent...
  64. ncbi Adrenergic receptors on smooth muscle cells isolated from human penile corpus cavernosum
    P Costa
    Service d Urologie, C H U Gaston Doumergue, Nimes and Faculté de Pharmacie, Montpellier, France
    J Urol 150:859-63. 1993
    ..These receptors are coupled with the contraction of the cell and are blocked by the alpha 1-adrenergic antagonists moxisylyte or prazosin...
  65. ncbi Inhibition of human plasma leucine5-enkephalin aminopeptidase hydrolysis by various endogenous peptides and a select number of clinically used drugs
    Aron D Mosnaim
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science The Chicago Medical School, N Chicago, Illinois 60064, USA
    Am J Ther 11:459-65. 2004
    ..Whether their development could find useful pharmacological applications remains to be explored...
  66. ncbi Activation of a NADH dehydrogenase in the human erythrocyte by beta-adrenergic agonists: possible involvement of a G protein in enzyme activation
    F Marques
    Central Analysis Laboratory, Aveiro University, Portugal
    Biol Signals 6:52-61. 1997
  67. ncbi Postsynaptic alpha 2-adrenoceptors mediate melanosome aggregation in melanophores of the white-spotted rabbitfish (Siganus canaliculatus)
    M H Amiri
    Department of Biology, Faculty of Science, UAE University, Al Ain, United Arab Emirates
    Pak J Biol Sci 12:1-10. 2009
    ..The present data demonstrate that the nature of melanophore innervation in this teleost is adrenergic and neuro-melanophore signals mediating melanosome aggregation are transmitted through alpha-2 postsynaptic adrenoceptors...
  68. ncbi Adrenergic modulation of hepatotoxicity
    S M Roberts
    Center for Environmental and Human Toxicology, University of Florida, Gainesville 32610, USA
    Drug Metab Rev 29:329-53. 1997
    ..toxicity is increased by adrenergic agonist drugs (group I) and the other whose toxicity is decreased by adrenergic antagonists (group II). Group I includes carbon tetrachloride, acetaminophen, and methylphenidate...
  69. ncbi [5-HT1A/1B receptors, alpha2-adrenoceptors and the post-receptor adenylate cyclase activation in the mice brain are involved in the antidepressant-like action of agmatine]
    Xian Zhong Jiang
    Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
    Yao Xue Xue Bao 43:467-73. 2008
    ..These results indicate that regulation on 5-HT1A/1B and alpha2 receptors, and activation AC in the frontal cortex is one of the important mechanisms involving in agmatine's antidepressant-like action...
  70. ncbi Acute ventricular rate control in atrial fibrillation and atrial flutter
    Ijaz A Khan
    Division of Cardiology, Creighton University School of Medicine, 3006 Webster Street, Omaha, NE 68131 2044, USA
    Int J Cardiol 97:7-13. 2004
    ..Factors precipitating rapid ventricular rate should be treated as well...
  71. ncbi Treatment of poisoning caused by beta-adrenergic and calcium-channel blockers
    Greene Shepherd
    Medical College of Georgia, 1120 15th Street, CJ 1020, Augusta, 30912 2450, USA
    Am J Health Syst Pharm 63:1828-35. 2006
    ..The toxic effects and treatment of beta-adrenergic blocker and calcium-channel blocker (CCB) overdose are reviewed...
  72. ncbi Autonomic control of heart rate during forced activity and digestion in the snake Boa constrictor
    T Wang
    Department of Zoology, UNESP Rio Claro, Brazil
    J Exp Biol 204:3553-60. 2001
  73. ncbi Pharmacokinetics of topical beta-adrenergic antagonists in rabbit aqueous humor evaluated with the microdialysis method
    R Ohtori
    Department of Ophthalmology, Showa University School of Medicine, 1 5 8 Hatanodai, Tokyo, Shinagawa ku, 142 0064, Japan
    Exp Eye Res 66:487-94. 1998
    The microdialysis method was used to evaluate the pharmacokinetics of the beta-adrenergic antagonists carteolol and timolol and the new ophthalmic solution WP-934 in rabbit aqueous humor, following instillation...
  74. ncbi Adrenergic response of splanchnic arteries from cirrhotic patients: role of nitric oxide, prostanoids, and reactive oxygen species
    Adely Salcedo
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma, Madrid, Spain
    Exp Biol Med (Maywood) 232:1360-7. 2007
    ..Products dependent on NAD(P)H oxidase might contribute to the adrenergic response in splanchnic arteries from control and cirrhotic patients...
  75. ncbi Effect of nicotine and ephedrine on the accumulation of 18F-FDG in brown adipose tissue
    Shingo Baba
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore Maryland 21287, USA
    J Nucl Med 48:981-6. 2007
    ..This study evaluated the effect of various beta-adrenergic agonists on (18)F-FDG uptake in brown adipose tissue (BAT) in rats using ex vivo biodistribution studies...
  76. ncbi Inhibitors of 5alpha-reductase in the treatment of benign prostatic hyperplasia
    T H Tarter
    Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62707, USA
    Curr Pharm Des 12:775-83. 2006
    ..of symptomatic BPH include 1) the 5alpha-reductase inhibitors finasteride and dutasteride, 2) the alpha1-adrenergic antagonists doxazocin, terazosin, tamsulosin, and alfuzosin, and 3) the combination of a 5alpha-reductase inhibitor ..
  77. ncbi Suppression of collagen production in norepinephrine stimulated cardiac fibroblasts culture: differential effect of alpha and beta-adrenoreceptor antagonism
    Ka Bik Lai
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR
    Cardiovasc Drugs Ther 23:271-80. 2009
  78. ncbi Beta-blockers and progression of coronary atherosclerosis: pooled analysis of 4 intravascular ultrasonography trials
    Ilke Sipahi
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Intern Med 147:10-8. 2007
    ..However, whether a direct influence of beta-blockers on coronary atherosclerosis contributes to reduced recurrent myocardial infarction and total mortality rates is not known...
  79. pmc Autonomic drugs and the accommodative system in rhesus monkeys
    Lisa A Ostrin
    University of Houston College of Optometry, 505 J Davis Armistead Bldg, Houston, TX 77204, USA
    Exp Eye Res 90:104-12. 2010
    ..Low dose echothiophate had significant effects on pupil diameter and resting refraction, with only small effects on the dynamics of the accommodative response...
  80. ncbi Design and evaluation of nitrosylated alpha-adrenergic receptor antagonists as potential agents for the treatment of impotence
    I S de Tejada
    Departamento de Investigacion, Hospital Ramon y Cajal, Fundacion para la Investigacion y el Desarrollo en Andrologia, Madrid, Spain
    J Pharmacol Exp Ther 290:121-8. 1999
    ..These drugs induced penile erection in animals, suggesting their possible therapeutic value as agents for the local pharmacological treatment of impotence...
  81. ncbi The effect of maternal catecholamines on the caliber of gravid uterine microvessels
    Scott Segal
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Anesth Analg 106:888-92, table of contents. 2008
    ..Because EPI exerts predominantly beta-adrenergic, and NE predominantly alpha-adrenergic effects in circulating concentrations, we hypothesized that these changes could lead to uterine arteriole vasoconstriction...
  82. ncbi Effect of pharmacological blockade on cardiovascular responses to voluntary and forced diving in muskrats
    P E Signore
    Department of Zoology, University of British Columbia, Vancouver, Canada
    J Exp Biol 198:2307-15. 1995
    ..Phentolamine did not affect diving bradycardia, indicating that diving bradycardia occurs independently of peripheral vasoconstriction.(ABSTRACT TRUNCATED AT 250 WORDS)..
  83. ncbi [Changes in autonomic control of heart rate after ischemic cerebral stroke]
    Nenad Lakusic
    Odjel za bolesti srca i krvnih zila Specijalna bolnica za medicinsku rehabilitaciju Gajeva 2 49 217 Krapinske Toplice
    Acta Med Croatica 57:269-73. 2003
    ..However, literature lacks relevant data on autonomic dysbalance after the acute phase of ischemic stroke. The aim of this study was to assess the level of autonomic dysbalance in patients after the acute phase of ischemic stroke...
  84. ncbi Restoration of neutrophil immunocompetence after cardiopulmonary bypass by beta-adrenergic blockers
    Benedikt Trabold
    Department of Anesthesiology, University Medical Center, Regensburg, Germany
    Surgery 147:562-74. 2010
    ..Therefore, we studied the importance of adrenoceptors for the immunomodulation of neutrophils by catecholamines in vitro...
  85. ncbi Prokinetic effect of alpha-adrenergic antagonist, and beta-adrenergic antagonist on gall-bladder motility in humans with gall-stone disease
    Subhasish Sengupta
    Department of Gastroenterology, Mayo General Hospital, Castlebar, Ireland
    Eur J Gastroenterol Hepatol 19:581-3. 2007
    The effects of cholinergic agents and vagal control on gall-bladder motility are well defined. Alpha adrenergic antagonists have been found in previous studies to have a prokinetic effect on gall-bladder motility in normal human patients...
  86. pmc Chronic exposure to elevated norepinephrine suppresses insulin secretion in fetal sheep with placental insufficiency and intrauterine growth restriction
    Rafael A Leos
    Dept of Animal Sciences, Univ of Arizona, Tucson, 85719, USA
    Am J Physiol Endocrinol Metab 298:E770-8. 2010
    ..Unlike controls, basal plasma glucose concentrations fell (P < or = 0.05) with adrenergic antagonists. GSIS responsiveness, measured by the change in insulin, was higher (8.9-fold, P < or = 0...
  87. ncbi Adrenergic regulation of ovarian androgen biosynthesis is mediated via beta 2-adrenergic theca-interstitial cell recognition sites
    E R Hernandez
    Department of Obstetrics, Gynecology, University of Maryland School of Medicine, Baltimore 21201
    Endocrinology 122:1592-602. 1988
    ..subject to stereospecific blockade by beta (propranolol)- but not alpha (phentolamine)-selective adrenergic antagonists. Further probing with subtype-selective adrenergic ligands revealed terbutaline (a beta 2-selective ..
  88. ncbi A review of combination therapy in patients with benign prostatic hyperplasia
    Kevin T McVary
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 3008, USA
    Clin Ther 29:387-98. 2007
    ..The differing mechanisms of action and areas of efficacy of these 2 drug classes make them promising candidates for combination therapy...
  89. ncbi Selectivity of atipamezole, yohimbine and tolazoline for alpha-2 adrenergic receptor subtypes: implications for clinical reversal of alpha-2 adrenergic receptor mediated sedation in sheep
    D D Schwartz
    Department of Anatomy, Physiology and Pharmacology, Auburn University, College of Veterinary Medicine, Alabama 36849, USA
    J Vet Pharmacol Ther 21:342-7. 1998
    ..The results from these studies suggest that atipamezole has a high affinity for the alpha2D-adrenergic receptor that appears to be the receptor subtype in sheep brainstem...
  90. ncbi Dexmedetomidine-induced cerebral hypoperfusion exacerbates ischemic brain injury in rats
    Takaaki Nakano
    Department of Anesthesiology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara 228 8555, Japan
    J Anesth 23:378-84. 2009
    ..We tested the hypothesis that dexmedetomidine-induced cerebral hypoperfusion exacerbates ischemic cerebral injury...
  91. ncbi Physiological and reproductive effects of beta adrenergic receptor antagonists in Daphnia magna
    Edward M Dzialowski
    Department of Biological Sciences, University of North Texas, Denton, 76203, USA
    Arch Environ Contam Toxicol 50:503-10. 2006
    ..Responses of the physiological biomarkers heart rate and metabolic activity suggest that propranolol and metoprolol exerts sublethal toxicity to D. magna at lower concentrations than observed in the classical endpoints...
  92. pmc Modulation of immunity in young-adult and aged squirrel, Funambulus pennanti by melatonin and p-chlorophenylalanine
    Seema Rai
    Department of Zoology, Pineal Research Lab, Banaras Hindu University, Varanasi 221005, India
    Immun Ageing 6:5. 2009
    ..Increased free radical load and decreased peripheral melatonin could be one of the reasons of immunosenescence...
  93. ncbi The hemodynamic effects of phenoxybenzamine in neonates, infants, and children
    Emad Mossad
    Department of Pediatric Anesthesia, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Clin Anesth 20:94-8. 2008
    ..To evaluate the hemodynamic effects of the long-acting, alpha-adrenergic blocker, phenoxybenzamine, in children of different age groups...
  94. ncbi Ultrastructural effects of topical beta-adrenergic antagonists and an alpha-adrenergic agonist on the rabbit cornea
    S Polat
    Department of Histology and Embryology, University of Cukurova Medical Faculty, Adana, Turkey
    Ophthalmologica 213:183-8. 1999
  95. ncbi Role of central nicotinic and beta-adrenergic receptors in the onset and further development of tail-tremor induced by repeated nicotine administration to rats
    K Suemaru
    Division of Pharmacy, Misasa Medical Branch, Okayama University Medical School, Tottori, Japan
    Naunyn Schmiedebergs Arch Pharmacol 355:571-5. 1997
    ..Moreover, spinal noradrenergic mechanisms may be involved in the manifestation of this phenomenon...
  96. ncbi Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: a randomized controlled trial
    Juan G Abraldes
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Gastroenterology 136:1651-8. 2009
    ..This randomized controlled trial evaluated the effects of continuous simvastatin administration on the hepatic venous pressure gradient (HVPG) and its safety in patients with cirrhosis and portal hypertension...
  97. ncbi The 2000 Canadian recommendations for the management of hypertension: Part one--therapy
    F A McAlister
    Division of General Internal Medicine, University of Alberta, Edmonton, Canada
    Can J Cardiol 17:543-59. 2001
    ..To provide updated, evidence-based recommendations for the therapy of hypertension in adults...
  98. ncbi Systemic absorption pathways of topically applied beta adrenergic antagonists in the pigmented rabbit
    Y H Lee
    Department of Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles 90033
    Exp Eye Res 57:341-9. 1993
    ..An equivalent amount of all four beta adrenergic antagonists was instilled directly into the nasolacrimal duct to assess the nasal contribution to systemic drug ..
  99. ncbi Comparative physiology, pharmacology and toxicology of beta-blockers: mammals versus fish
    Stewart F Owen
    Institute for the Environment, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
    Aquat Toxicol 82:145-62. 2007
    ..Finally, accurate citation of CAS numbers is essential for pharmaceuticals in order to compare nominal concentration data in terms of either the drug free base or the drug salt complex...
  100. ncbi Chiral separation of beta-adrenergic blockers on CelluCoat column by HPLC
    Imran Ali
    Department of Chemistry, Jamia Millia Islamia Central University, New Delhi 110025, India
    Talanta 78:458-63. 2009
    ..44-12.91, 1.12-2.19 and 1.00-9.50, respectively. The proposed supra-molecular models indicated that the chiral resolution were governed by pi-pi interactions, hydrogen bondings and steric effect...
  101. ncbi Three approaches to enantiomer separation of beta-adrenergic antagonists by capillary electrochromatography
    S Nilsson
    Technical Analytical Chemistry, Center for Chemistry and Chemical Engineering, Lund University, Sweden
    Electrophoresis 18:884-90. 1997
    Three different capillary electrochromatographic methods for the enantiomer separation of beta-adrenergic antagonists (acebutolol, alprenolol, atenolol, metoprolol, pindolol, prenalterol, and propranolol) were applied using different ..

Research Grants64

  1. The Role of Vascular Innervation on Tissue-type Plasminogen Activator Release
    ..With the overwhelming prevalence of vascular disease nationally, and worldwide, new insights and strategies have the potential translate to a tremendous public health impact...
  2. Quantitative Assessment of Oxidative Metabolism in Brown Fat
    Otto Muzik; Fiscal Year: 2011
    ..Moreover, these studies will provide important physiological information about fat metabolism that will likely translate into novel pharmacological approaches for the treatment of obesity. ..
  3. Treatment Implications of Trauma Memory Modulation for PTSD & Alcohol Dependence
    Michael E Saladin; Fiscal Year: 2010
  4. Low Thyroid function and myocardial infarction
    Anthony Martin Gerdes; Fiscal Year: 2013
    ..These animal data should provide important insight for interpretation of their clinical results and should also be of predictive value in planning future long-term treatment studies. ..
  5. Does doxazosin attenuate stress-induced smoking and improve clinical outcomes?
    SHERRY ANN MCKEE; Fiscal Year: 2012
    ..e., increases the ability to resist smoking, reduces ad- lib smoking) and improves clinical outcomes during a subsequent brief treatment phase (i.e., reductions in smoking behavior). ..
  6. Identifying brain mediators distinguishing eustress and distress impact on cancer
    Lei Cao; Fiscal Year: 2013
    ..Furthermore we will investigate the role of hypothalamic BDNF in mediating SI impact on cancer. These studies may reveal novel therapeutic targets for cancer prevention and treatment. ..
  7. Brain Norepinephrine and Stress Reactivity
    David A Morilak; Fiscal Year: 2012
    ..abstract_text> ..
  8. Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response.
    Fatta B Nahab; Fiscal Year: 2013
    ..Addressing these current barriers will lead to a better understanding of ET physiology, phenotypic variability and treatment mechanisms with the ultimate goal of reducing disability and improving quality of life. ..
  9. Mitigation of the Catecholamine Surge in Severely Burned Patients
    David N Herndon; Fiscal Year: 2013
    ..Further, this P50 Burn Center will translate this improved understanding and knowledge to clinical outcomes of burns in order to improve the standard of burn care. ..
  10. Effect of COMT genetic polymorphism on response to propranolol therapy in TMD
    ..Evaluation of propranolol efficacy for TMD therapy and identification of genetic predictors of the outcome of propranolol therapy will apply recent advances in genetic research to clinical practice. ..
  11. Pilot Trial of Carvedilol in Alzheimer's Disease
    Paul B Rosenberg; Fiscal Year: 2013
    ..In a population-based sample of incident AD, we observed that use of [unreadable]-adrenergic antagonists was associated with slower functional decline...
  12. OnabotulinumtoxinA (onaVoNT-A) vs Oral Tamsulosin for PBH &LUTS (#02-10-10-05)
    Christopher P Smith; Fiscal Year: 2013
    ..Data from this study will allow for the intelligent design of targeted therapies that will overcome refractoriness to the current standard of care. ..
  13. Targeting accessory proteins of alpha2C adrenergic receptor in Raynaud Phenomenon
    CATALIN FILIPEANU; Fiscal Year: 2013
    ..Also, we aim to establish a new model to test the effectiveness of current and future therapeutic approaches in RP. ..
  14. Development of Novel Therapies for Levodopa-induced Dyskinesia in Parkinson's Dis
    Nurulain T Zaveri; Fiscal Year: 2010
    ..Several non-dopaminergic approaches are being evaluated in clinical trials (5HT1A agonists, alpha adrenergic antagonists) and in preclinical studies (glutamate antagonists)...
  15. Effect of Prazosin on Alcohol Craving, Stress Dysregulation and Alcohol Relapse
    Rajita Sinha; Fiscal Year: 2013
    ..If the proposed hypotheses are supported, it will provide evidence for efficacy of Prazosin as a medication for alcoholism, particularly for those with co-morbid anxiety disorders. ..
  16. Norepinephrine and Dopamine: Mediating Drug vs. Natural Rewards
    Jill B Becker; Fiscal Year: 2013
    ..To test this hypothesis we will examine the effects of adrenergic antagonists in the NAc on the self-administration of cocaine and natural rewards (e.g., food) in male and female rats...
  17. Molecular mechanisms of hERG1 channel activators
  18. Identification of Erythrocyte Beta-adrenergic and Gs-mediated Pathways
    Sebastian Fernandez-Pol; Fiscal Year: 2011
    ..Knowledge concerning malaria invasion may result in the identification of drug targets and subsequent development of antimalarials, thus leading to reduced human suffering from this devastating parasite. ..
    K Y Pau; Fiscal Year: 2000
    ..Aim 3b will determine if electrical lesions of the nPGi and/or nPH prevent either the postcoital expression of LC cFos protein, TH/NET mRNAs or the LH surge. These studies may provide information on neurologically related infertility. ..
  20. Enhancing Disrupted Reconsolidation: Impact on Cocaine Craving, Reactivity &Use
    Michael E Saladin; Fiscal Year: 2013
    ..Confirmation of these expectations will set the stage for a clinical trial where the outcome enhancing properties of this novel pharmacy-behavior therapy could be systematically evaluated. ..
  21. Exploring the Feasibility of Computational Markers to Predict Atrial Fibrillation
    JAMES MARLOW BLUM; Fiscal Year: 2013
    ..These approaches will be validated on the data collected in Aim 1, and will be used to develop models based on non-parametric machine learning techniques to accurately assess PAF risk. ..
  22. Methylphenidate, vigilance, and visual perception
    Kara L Agster; Fiscal Year: 2010
    ..A series of adrenergic antagonists will be administered in conjunction with MPH to determine whether alpha or beta NE receptors contribute to ..
  23. Impact of Race and Genetic Factors on Beta-blocker Effectiveness in Heart Failure
    David E Lanfear; Fiscal Year: 2013
    ..Beta adrenergic antagonists (beta-blockers, BB) are the foundation of modern HF care, but their effectiveness in African Americans is ..
    Roberto Groszmann; Fiscal Year: 2003
    Abdulmaged Traish; Fiscal Year: 2003
    ..receptors, nitric oxide and VIP modulate smooth muscle function, 3) the activity, in vivo, of alpha-adrenergic antagonists, VIP and nitric oxide on clitoral and vaginal hemodynamic response to pelvic nerve stimulation and 4) the ..
    JAMES O DONNELL; Fiscal Year: 1990
    ..Moreover, these results may have clinical relevance for the pharmacological treatment of cocaine abuse...
    Michael Schreiber; Fiscal Year: 1992
    ..These studies will provide a better understanding of the vascular effects of cocaine on the developing fetal neurovasculature and of the clinical neurological complications associated with prenatal cocaine abuse...
    Jorge Figueroa; Fiscal Year: 1993
    ..These studies will provide a better understanding of preterm, term and postterm labor and delivery and lead to more rational therapies, in particular of preterm labor...
    Andrew Goddard; Fiscal Year: 2000
    ROLAND DICKERSON; Fiscal Year: 1992 pharmacologic probes to better understand the possible mechanism for their anti-proteolytic effects. Ultimately, these studies will provide a basis for the logical extension of this work to critically ill patients with sepsis. ..
  31. Altered Baroreflex Responses by Dietary Sodium
    STEVEN BEALER; Fiscal Year: 2003 responses from rats given neurotoxic lesions of this brain area, or treated with selective alpha-adrenergic antagonists prior to testing...
  32. Acetylcholine in Diabetic Enteric Nervous System
    KATHY LEPARD; Fiscal Year: 2004
    ..Abnormal motility will be corrected pharmacologically using serotonin4 agonists, alpha-adrenergic antagonists and/or antagonists of nitric oxide synthase...
    DAVID KROHN; Fiscal Year: 1980
    ..Preliminary results suggest that the Timolol retained in the cornea may act in part as a therapeutic "reservoir", in contrast to pilocarpine...
    WENDEL NELSON; Fiscal Year: 1990
    ..Experiments will be done in vitro (fractions from rat homogenates and human liver) and in vivo (in rats). Limited experiments in human subjects are proposed...
    ROBERT LA MOTTE; Fiscal Year: 2002
    Steven Lipshultz; Fiscal Year: 1993
  37. Post Coronary Bypass Atrial Arrhythmic Prediction Rule
    Rod Passman; Fiscal Year: 2006
    ..This project will be an integral part of the candidate?s career development plan and his maturation as an epidemiologist, cardiac electrophysiologist, and clinical investigator. ..
  38. Translating Extinction of Fear to Anxiety Disorder Treatment
    Mark Barad; Fiscal Year: 2006
    ..These experiments should help establish the translational validity of the extinction model for anxiety disorder treatment and also may yield potential improvements in current anxiety disorder treatments. ..
    Margaret Warner; Fiscal Year: 1993
    ..Thus, neuropeptide Y is likely to play a role in the moment to moment regulation of cardiac function by the autonomic nervous system...
    Michael Barry; Fiscal Year: 1999
    Stephen Stahl; Fiscal Year: 1992
  42. Fatigue After Myocardial Infarction in Older Adults
    Patricia Crane; Fiscal Year: 2005
    ..Medication may also be an important correlate of fatigue after Ml. Use of beta adrenergic antagonists (beta-blockers) after Ml is an American Heart Association class I recommendation...
    Michel Pontari; Fiscal Year: 1999
    ..4. Perform the following multicenter treatment protocols: a) empiric antibiotic therapy; b) alpha adrenergic antagonists using videourodynamic finding; c) gabapentin for treatment of the associated pain; and d) correlation of ..
    Dean Li; Fiscal Year: 2000
    ..The effect of beta adrenergic antagonists to reduce hemodynamic stress and vitamin D to modulate ELN expression on SVAS will be examined in our ..
    ABRAHAM COCKETT; Fiscal Year: 1992
    David Driscoll; Fiscal Year: 1980
    ..function by testing the response of the preparations at different ages to (1) adrenergic agonists, (2) adrenergic antagonists, (3) prostaglandin synthetase inhibitors, and (4) inotropic and vasodilator drugs...
    TAG MANSOUR; Fiscal Year: 1990
    ..Through the use of specific alpha and beta adrenergic blockers we intend to ascertain the pharmacological nature of activation of this enzyme by epinephrine and its congeners...
  48. ESCAPE Mechanistic Substudies
    Robert Califf; Fiscal Year: 2003
    ..evaluate the relations between levels of natriuretic peptides, troponins, and the treatment effects of B-adrenergic antagonists and inotropic agents on clinical outcomes...
    Richard Crook; Fiscal Year: 2001
    ..A major treatment strategy for this disease is the reduction of aqueous humor secretion with B-adrenergic antagonists such as timolol and other drugs...
  50. Binge Drinking & Cigarette Smoking: A Rodent Model
    Mariann Piano; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
    JERRY WEBB; Fiscal Year: 1991
  52. Tracking Urogenital Sinus Cell Progeny
    ROBERT SIKES; Fiscal Year: 2004
    ..abstract_text> ..
    Richard Atkinson; Fiscal Year: 1999
    ..protein (UCP) and UCP mRNA in brown adipose tissue, NE turnover in multiple organs, and the ability to adrenergic antagonists to prevent weight loss with VIT...
  54. Retinal ganglion cell loss in aging mice.
    Thomas Mittag; Fiscal Year: 2007
  55. Reconsolidation of Emotional Memory in Humans
    Elizabeth Phelps; Fiscal Year: 2009
    ..memories are reconsolidated each time after retrieval, and that protein synthesis inhibitors or beta-adrenergic antagonists can impair this process (e.g., Nadar et al., 2000;Debiec and Ledoux, 2004)...
    Ching Shih Chen; Fiscal Year: 1993
    ..Similar approaches will be take to scrutinize the metabolic inversion of beta-adrenergic blockers...
    Mariann Piano; Fiscal Year: 2000
    ..The results of this study will lead to a better understanding of the pathophysiology of alcoholic cardiomyopathy and rational development of therapeutic innervations to prevent and treat alcohol-induced cardiomyopathy. ..
  58. Stress, Rearing, and Ethanol Reinforcement in Monkeys
    James Woods; Fiscal Year: 2005
    ..These studies will contribute to a better understanding of the biological basis of alcoholism, which is a first step toward the development of effective pharmacotherapeutic interventions. ..
    James James; Fiscal Year: 2004
    ..Results of these studies will clarify metabolic relationships that are important both in health and disease. ..
    Christine Gleason; Fiscal Year: 1999
    NORTON NEFF; Fiscal Year: 1992
    ..These studies will change our concepts about neuronal AAAD and provide insight into the mechanism of action of psychoactive drugs...
  62. Memory Reconsolidation Blockade as a Novel Intervention for Nicotine Dependence
    A Evins; Fiscal Year: 2009
    ..Outcome measures will include physiological responses to smoking-related cues after one and six post-reactivation treatments and smoking behavior during the treatment and during a 3- month follow-up period. ..
    Robert Freedman; Fiscal Year: 1999
    ..Finally, this research will determine if adrenergic antagonists or a compound that releases nitric oxide from vascular endothelium can actually block Raynaud's attacks ..
    James McNamara; Fiscal Year: 1993