adrenergic agents

Summary

Summary: Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Top Publications

  1. ncbi Comparison of bilaterally 6-OHDA- and MPTP-lesioned rats as models of the early phase of Parkinson's disease: histological, neurochemical, motor and memory alterations
    Marcelo Machado Ferro
    Departamento de Farmacologia, Universidade Federal do Parana, Curitiba, Brazil
    J Neurosci Methods 148:78-87. 2005
  2. ncbi Lesions of dopaminergic neurons in the substantia nigra pars compacta and in the ventral tegmental area enhance depressive-like behavior in rats
    Christine Winter
    Department of Psychiatry and Psychotherapy, Charite Campus Mitte, Germany
    Behav Brain Res 184:133-41. 2007
  3. ncbi The induction of cardiac ornithine decarboxylase by β2 -adrenergic agents is associated with calcium channels and phosphorylation of ERK1/2
    Andrés J López-Contreras
    Faculty of Medicine, Department of Biochemistry and Molecular Biology B and Immunology, University of Murcia, Murcia, Spain
    J Cell Biochem 114:1978-86. 2013
  4. ncbi Neurotrophic effects of bone morphogenetic protein-7 in a rat model of Parkinson's disease
    B K Harvey
    National Institute on Drug Abuse, NIH, Neural Protection and Regeneration Section, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res 1022:88-95. 2004
  5. pmc L-DOPA-induced dysregulation of extrastriatal dopamine and serotonin and affective symptoms in a bilateral rat model of Parkinson's disease
    K L Eskow Jaunarajs
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, Binghamton, NY 13902 6000, USA
    Neuroscience 218:243-56. 2012
  6. pmc Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
    Lars M Bjorklund
    Udall Parkinson s Disease Research Center of Excellence, Neuroregeneration Laboratories, and Molecular Neurobiology Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 99:2344-9. 2002
  7. ncbi Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's disease
    M T Tadaiesky
    Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, Campus Universitario, Trindade, Florianopolis, SC, Brazil
    Neuroscience 156:830-40. 2008
  8. ncbi Dopamine depletion increases the power and coherence of beta-oscillations in the cerebral cortex and subthalamic nucleus of the awake rat
    Andrew Sharott
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Eur J Neurosci 21:1413-22. 2005
  9. ncbi Effects of adrenergic agents on intracellular Ca2+ homeostasis and metabolism of glucose in astrocytes with an emphasis on pyruvate carboxylation, oxidative decarboxylation and recycling: implications for glutamate neurotransmission and excitotoxicity
    Linea F Obel
    Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, 2 Universitetsparken, 2100 Copenhagen, Denmark
    Neurotox Res 21:405-17. 2012
  10. ncbi Favorable effects of VEGF gene transfer on a rat model of Parkinson disease using adeno-associated viral vectors
    You yong Tian
    Department of Neurology, The Affiliated Union Hospital of Huazhong University of Science and Technology, Wuhan 430022, PR China
    Neurosci Lett 421:239-44. 2007

Detail Information

Publications255 found, 100 shown here

  1. ncbi Comparison of bilaterally 6-OHDA- and MPTP-lesioned rats as models of the early phase of Parkinson's disease: histological, neurochemical, motor and memory alterations
    Marcelo Machado Ferro
    Departamento de Farmacologia, Universidade Federal do Parana, Curitiba, Brazil
    J Neurosci Methods 148:78-87. 2005
    ..The picture of mild motor effects and robust impairment of habit learning and spatial working memory observed in MPTP-lesioned rats models the early phase of Parkinson's disease...
  2. ncbi Lesions of dopaminergic neurons in the substantia nigra pars compacta and in the ventral tegmental area enhance depressive-like behavior in rats
    Christine Winter
    Department of Psychiatry and Psychotherapy, Charite Campus Mitte, Germany
    Behav Brain Res 184:133-41. 2007
    ..The effects of citalopram administration on depressive behavior induced by lesions of dopaminergic brain regions furthermore suggest an involvement of serotonergic pathways in dopaminergic cell loss-induced depression...
  3. ncbi The induction of cardiac ornithine decarboxylase by β2 -adrenergic agents is associated with calcium channels and phosphorylation of ERK1/2
    Andrés J López-Contreras
    Faculty of Medicine, Department of Biochemistry and Molecular Biology B and Immunology, University of Murcia, Murcia, Spain
    J Cell Biochem 114:1978-86. 2013
    ..that the induction of cardiac ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, by beta-adrenergic agents may have in heart hypertrophy is a controversial issue...
  4. ncbi Neurotrophic effects of bone morphogenetic protein-7 in a rat model of Parkinson's disease
    B K Harvey
    National Institute on Drug Abuse, NIH, Neural Protection and Regeneration Section, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res 1022:88-95. 2004
    ..In summary, our data suggest that BMP7 has neuroprotective and/or neuroreparative effects against 6-OHDA lesioning of the nigrostriatal DA pathway in an animal model of Parkinson's disease (PD)...
  5. pmc L-DOPA-induced dysregulation of extrastriatal dopamine and serotonin and affective symptoms in a bilateral rat model of Parkinson's disease
    K L Eskow Jaunarajs
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, Binghamton, NY 13902 6000, USA
    Neuroscience 218:243-56. 2012
    ..Collectively, these results suggest that chronic L-DOPA treatment may interfere with the balance of DA and 5-HT function in affect-related brain regions and could induce and/or exacerbate non-motor symptoms in PD...
  6. pmc Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
    Lars M Bjorklund
    Udall Parkinson s Disease Research Center of Excellence, Neuroregeneration Laboratories, and Molecular Neurobiology Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 99:2344-9. 2002
    ..These results demonstrate that transplanted ES cells can develop spontaneously into DA neurons. Such DA neurons can restore cerebral function and behavior in an animal model of Parkinson's disease...
  7. ncbi Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's disease
    M T Tadaiesky
    Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, Campus Universitario, Trindade, Florianopolis, SC, Brazil
    Neuroscience 156:830-40. 2008
    ....
  8. ncbi Dopamine depletion increases the power and coherence of beta-oscillations in the cerebral cortex and subthalamic nucleus of the awake rat
    Andrew Sharott
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Eur J Neurosci 21:1413-22. 2005
    ..These changes may be important in regulating movement...
  9. ncbi Effects of adrenergic agents on intracellular Ca2+ homeostasis and metabolism of glucose in astrocytes with an emphasis on pyruvate carboxylation, oxidative decarboxylation and recycling: implications for glutamate neurotransmission and excitotoxicity
    Linea F Obel
    Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, 2 Universitetsparken, 2100 Copenhagen, Denmark
    Neurotox Res 21:405-17. 2012
    ....
  10. ncbi Favorable effects of VEGF gene transfer on a rat model of Parkinson disease using adeno-associated viral vectors
    You yong Tian
    Department of Neurology, The Affiliated Union Hospital of Huazhong University of Science and Technology, Wuhan 430022, PR China
    Neurosci Lett 421:239-44. 2007
    ..We thus conclude that intrastriatal delivery of VEGF gene mediated by AAV has favorable effects on the dopaminergic neurons in a rat Parkinson disease model...
  11. ncbi Progressive and extensive dopaminergic degeneration induced by convection-enhanced delivery of 6-hydroxydopamine into the rat striatum: a novel rodent model of Parkinson disease
    Yoshitsugu Oiwa
    Molecular Therapeutics Section, Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Neurosurg 98:136-44. 2003
    ..To make an extensive lesion, the authors used a convection-enhanced delivery (CED) method for intrastriatal infusion of 6-OHDA and evaluated the animals for a model of Parkinson disease (PD)...
  12. ncbi EEG modifications in the cortex and striatum after dopaminergic priming in the 6-hydroxydopamine rat model of Parkinson's disease
    Vasily V Vorobyov
    Institute of Cell Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia
    Brain Res 972:177-85. 2003
    ..Development of priming might be related to the degree and cortical/striatal ratio of EEG power inhibition produced by dopamine agonists...
  13. ncbi The involvement of NF-kappaB p65/p52 in the effects of GDNF on DA neurons in early PD rats
    Jun Ping Cao
    Department of Neurobiology, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu 221002, PR China
    Brain Res Bull 76:505-11. 2008
    ..And it was the noncanonical NF-kappaB signaling pathway, which contained the NF-kappaB p65/p52 complex that was involved in the effects of GDNF on DA neurons...
  14. ncbi Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in rats
    J Srinivasan
    Zoological Institute, Neuropharmacology, University of Tuebingen, Auf der Morgenstelle 28E, 72076, Tuebingen, Germany
    Eur J Neurosci 17:2586-92. 2003
    ....
  15. ncbi Nigrostriatal damage with 6-OHDA: validation of routinely applied procedures
    Federica Fulceri
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma 55, 56126 Pisa, Italy
    Ann N Y Acad Sci 1074:344-8. 2006
    ..These results suggest that the flow rate and the volume of 6-OHDA infusion are critical to prevent the occurrence of nonspecific mechanical effects...
  16. ncbi Substantia nigra compacta neurons that innervate the reticular thalamic nucleus in the rat also project to striatum or globus pallidus: implications for abnormal motor behavior
    V Anaya-Martinez
    Departamento de Fisiologia, Biofisica y Neurociencias, CINVESTAV, Apartado Postal 14 740, Mexico D F, 07000 Mexico
    Neuroscience 143:477-86. 2006
    ..The fact that lesion of a single dopaminergic neuron can reduce dopamine transmission in more than one structure is probably important in generating the manifestations of Parkinson's disease...
  17. ncbi Ampakines reduce methamphetamine-driven rotation and activate neocortex in a regionally selective fashion
    U S Hess
    Department of Anatomy and Neurobiology, Gillespie Neuroscience Research Facility, University of California at Irvine, Irvine, CA 92697 4292, USA
    Neuroscience 121:509-21. 2003
    ....
  18. ncbi Microglial activation with atypical proinflammatory cytokine expression in a rat model of Parkinson's disease
    Amaicha M Depino
    Institute Leloir Foundation CONICET University of Buenos Aires, Avenue Patricias Argentinas 435, 1405 Buenos Aires, Argentina
    Eur J Neurosci 18:2731-42. 2003
    ..The production of proinflammatory cytokines from "primed" microglia may in turn modulate disease progression as has been recently proposed in a model of prion disease...
  19. ncbi Bradykinin receptor agonist facilitates low-dose cyclosporine-A protection against 6-hydroxydopamine neurotoxicity
    Cesario V Borlongan
    Cellular Neurobiology Branch, NIH NIDA IRP, 5500 Nathan Shock Drive, 21224, Baltimore, MD, USA
    Brain Res 956:211-20. 2002
    ..The safer and effective administration of lower doses of CsA combined with enhanced BBB permeability using Cereport, offers a novel way of producing protective effects in the CNS without the toxic liabilities of high-dose CsA...
  20. ncbi Therapeutic effect of microencapsulated porcine retinal pigmented epithelial cells transplantation on rat model of Parkinson's disease
    Hou Liang Zhang
    Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China
    Neurosci Bull 23:137-44. 2007
    ..To investigate the therapeutic effect of microencapsulated porcine retinal pigmented epithelial cells (RPE-M) transplantation on rat model of Parkinson's disease (PD)...
  21. ncbi Functional effect of FGF2- and FGF8-expanded ventral mesencephalic precursor cells in a rat model of Parkinson's disease
    Pia Jensen
    Department of Anatomy and Neurobiology, Institute of Medical Biology, University of Southern Denmark, Winsløwparken 21, DK 5000 Odense C, Denmark
    Brain Res 1218:13-20. 2008
    ..05) or control cells (P<0.01). In conclusion, FGF2-mediated pregrafting expansion of primary VM precursor cells considerably improves dopaminergic cell survival and functional restoration in a rat model of PD...
  22. ncbi Intrapallidal metabotropic glutamate receptor activation in a rat model of Parkinson's disease: behavioral and histological analyses
    Takashi Agari
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, Japan, 700 8558
    Brain Res 1203:189-96. 2008
    ..The results indicate that the blockade of amphetamine-induced rotations might be at least partially mediated by group I mGluR activation. This study advances the use of selective group I mGluRs directed toward the GP for PD treatment...
  23. ncbi Generation of a alpha-synuclein-based rat model of Parkinson's disease
    Alessandra Recchia
    Department of Pharmacology and Anesthesiology, University of Padua, Largo Meneghetti, 2, 35131 Padua, Italy
    Neurobiol Dis 30:8-18. 2008
    ....
  24. pmc Autologous transplants of Adipose-Derived Adult Stromal (ADAS) cells afford dopaminergic neuroprotection in a model of Parkinson's disease
    Melissa K McCoy
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Exp Neurol 210:14-29. 2008
    ..ADAS cells may be ideal for ex vivo gene transfer therapies in Parkinson's disease treatment...
  25. ncbi Dopaminergic neuroprotection and regeneration by neurturin assessed by using behavioral, biochemical and histochemical measurements in a model of progressive Parkinson's disease
    Yoshitsugu Oiwa
    Department of Neurological Surgery, Wakayama Medical University, Kimiidera 811 1, Wakayama 641 0012, Japan
    Brain Res 947:271-83. 2002
    ....
  26. ncbi Dopamine depletion causes fragmented clustering of neurons in the sensorimotor striatum: evidence of lasting reorganization of corticostriatal input
    Jeiwon Cho
    Department of Psychology, Rutgers University, New Brunswick, New Jersey 08903, USA
    J Comp Neurol 452:24-37. 2002
    ..Switched signals could partially explain parkinsonian deficits in motor functions involving somatosensory guidance and their intractability to L-DOPA therapy-particularly if the switching involves sprouting...
  27. ncbi Does the cerebral cortex exacerbate dopaminergic cell death in the substantia nigra of 6OHDA-lesioned rats?
    Natasha Luquin
    Department of Anatomy and Histology, University of Sydney, Australia
    Parkinsonism Relat Disord 14:213-23. 2008
    ..Hence, prior cortical removal in 6OHDA-lesioned rats neuroprotected vSNc--but not VTA or dSNc--dopaminergic cells from death...
  28. ncbi Treatment of Parkinson disease with C17.2 neural stem cells overexpressing NURR1 with a recombined republic-deficit adenovirus containing the NURR1 gene
    Qing Jun Li
    Department of Neurology, Dong Guan People Hospital, Dong Guan 523018, China
    Synapse 61:971-7. 2007
    ..These results suggest a potential therapeutic benefit for Ad-NURR1-expressing cells in the treatment of PD. The Ad-NURR1 modification induced NSC differentiation and therefore represents a potential therapy for PD...
  29. ncbi Compromised circadian function in Parkinson's disease: enucleation augments disease severity in the unilateral model
    Gregory L Willis
    The Bronowski Institute of Behavioural Neuroscience, Neurosciences Section, Coliban Medical Centre, 19 Jennings Street, Kyneton, Victoria 3444, Australia
    Behav Brain Res 193:37-47. 2008
    ....
  30. ncbi Protective effects of green tea polyphenols in the 6-OHDA rat model of Parkinson's disease through inhibition of ROS-NO pathway
    Shuhong Guo
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Academia Sinica, Beijing, China
    Biol Psychiatry 62:1353-62. 2007
    ..Our in vitro experiments suggested that green tea polyphenols (GTP) might protect dopamine neurons through inhibition of NO and reactive oxygen species (ROS)...
  31. ncbi Dopaminergic neuroprotection by neurturin-expressing c17.2 neural stem cells in a rat model of Parkinson's disease
    Wei Guo Liu
    Department of Neurology, Clinical and Research Center for Parkinson Disease and Movement Disorders, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China
    Parkinsonism Relat Disord 13:77-88. 2007
    ..2 and Mock-c17.2 groups. Taken together, our results suggest that transplantation of NTN-secreting NSCs exerted protective on PD rat models...
  32. ncbi Characterization of dopamine-dependent rewarding and locomotor stimulant effects of intravenously-administered methylphenidate in rats
    L H L Sellings
    Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Room 1325, Montreal, Quebec, Canada H3G 1Y6
    Neuroscience 141:1457-68. 2006
    ..As well, they suggest that different ventral striatal subregions mediate the rewarding (anteromedial olfactory tubercle) and locomotor stimulant (accumbens core) effects of methylphenidate...
  33. ncbi Neuroprotective effects of vascular endothelial growth factor (VEGF) upon dopaminergic neurons in a rat model of Parkinson's disease
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan
    Eur J Neurosci 19:1494-504. 2004
    ..Further, VEGF is likely to promote neuroprotection indirectly by activating the proliferation of glia and by promoting angiogenesis. Our results support a potential neuroprotective role for VEGF in the treatment of Parkinson's disease...
  34. ncbi Enriched environment induces cellular plasticity in the adult substantia nigra and improves motor behavior function in the 6-OHDA rat model of Parkinson's disease
    Barbara Steiner
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Str 10, 13125 Berlin, Germany
    Exp Neurol 199:291-300. 2006
    ..Thus, physiological neurogenic and gliogenic stimuli induce significant microenvironmental changes in the adult SN and improve motor behavior in the 6-OHDA lesion model of PD...
  35. ncbi Dopamine manipulation alters immediate-early gene response of striatal parvalbumin interneurons to cortical stimulation
    Jennifer T Trevitt
    Psychology Department, California State University, Fullerton, 92631, USA
    Brain Res 1035:41-50. 2005
    ..Taken together, these results indicate that DA may importantly control striatal output via influences on PV-ir interneurons. Possible mechanisms for these influences are discussed...
  36. ncbi Striatal glutamate release evoked in vivo by NMDA is dependent upon ongoing neuronal activity in the substantia nigra, endogenous striatal substance P and dopamine
    Matteo Marti
    Department of Experimental and Clinical Medicine, Section of Pharmacology, and Neuroscience Center, University of Ferrara, Ferrara, Italy
    J Neurochem 93:195-205. 2005
    ..Endogenous striatal dopamine inhibits or potentiates the NMDA action depending on the strength of the excitatory stimulus (i.e. the NMDA concentration)...
  37. ncbi Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-induced behavioral sensitization in dyskinetic rats
    Véronique Sgambato-Faure
    INSERM U318, Laboratoire de Neurosciences Précliniques, CHU Pavillon B, Grenoble, France
    J Neuropathol Exp Neurol 64:936-47. 2005
    ....
  38. ncbi The therapeutic effects of dopamine replacement therapy and its psychiatric side effects are mediated by pineal function
    Gregory L Willis
    The Bronowski Institute of Behavioural Neuroscience, Coliban Medical Centre, 19 Jennings Street, Kyneton 3444, Vic, Australia
    Behav Brain Res 160:148-60. 2005
    ..These results provide compelling evidence that altered pineal function plays a major role in the aetiology of PD, the therapeutic effect of anti-Parkinsonian drugs and in the psychiatric side effects of DART...
  39. ncbi Neurorescue effects of VEGF on a rat model of Parkinson's disease
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Brain Res 1053:10-8. 2005
    ..Our results suggest that VEGF is a highly potent neurorescue molecule for Parkinson's disease therapy...
  40. ncbi Platelet-derived growth factor (PDGF-BB) and brain-derived neurotrophic factor (BDNF) induce striatal neurogenesis in adult rats with 6-hydroxydopamine lesions
    P Mohapel
    Section for Neuronal Survival, Wallenberg Neuroscience Center, BMC A 10, SE 221 84 Lund, Sweden
    Neuroscience 132:767-76. 2005
    ..In conclusion, our results suggest that administration of these growth factors is capable of recruiting new neurons into the striatum of hemiparkinsonian rats...
  41. ncbi Effect of AdGDNF on dopaminergic neurotransmission in the striatum of 6-OHDA-treated rats
    A D Smith
    Department of Neurology, University of Pittsburgh, S 510 Biomedical Science Tower, Pittsburgh, PA 15213, USA
    Exp Neurol 193:420-6. 2005
    ..Thus, DA neurotransmission within the striatum of 6-OHDA treated rats appears to be enhanced by increased expression of GDNF in the nigra...
  42. ncbi Effect of intrastriatal 6-OHDA lesion on dopaminergic innervation of the rat cortex and globus pallidus
    Thomas Debeir
    INSERM U679, Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75013, Paris, France
    Exp Neurol 193:444-54. 2005
    ....
  43. ncbi Effect of acupuncture on 6-hydroxydopamine-induced nigrostratal dopaminergic neuronal cell death in rats
    Yeung Kee Kim
    Department of Rehabilitation Medicine, Oriental Medical Hospital, College of Oriental Medicine, Kyungwon University, 20 8 Songpa dong, Songpa Gu, Seoul 138 170, Republic of Korea
    Neurosci Lett 384:133-8. 2005
    ..These effects of acupuncture were not observed for the non-acupoint (hip) acupuncture. The present study shows that acupuncture at the ST36 acupoint can be used as a useful strategy for the treatment of Parkinson's disease...
  44. ncbi Dissociation between short-term increased graft survival and long-term functional improvements in Parkinsonian rats overexpressing glial cell line-derived neurotrophic factor
    Biljana Georgievska
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, BMC A11, 22184, Lund, Sweden
    Eur J Neurosci 20:3121-30. 2004
    ....
  45. ncbi Behavioral and anatomical effects of quinolinic acid in the striatum of the hemiparkinsonian rat
    M E Olds
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Synapse 55:26-36. 2005
    ....
  46. ncbi Sparing of behavior and basal extracellular dopamine after 6-hydroxydopamine lesions of the nigrostriatal pathway in rats exposed to a prelesion sensitizing regimen of amphetamine
    Isabella Anna Moroz
    Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, PQ, Canada
    Exp Neurol 189:78-93. 2004
    ..The potential role of amphetamine-induced endogenous neurotrophic factors in the behavioral sparing and normalization of basal extracellular DA levels observed after subsequent 6-OHDA lesions is discussed...
  47. ncbi Angiotensin type-1-receptor antagonists reduce 6-hydroxydopamine toxicity for dopaminergic neurons
    P Rey
    Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    Neurobiol Aging 28:555-67. 2007
    ..Angiotensin may play a pivotal role, via AT(1) receptors, in increasing the oxidative damage of dopaminergic cells, and treatment with AT(1) antagonists may reduce the progression of Parkinson's disease...
  48. ncbi Behavioral and neurochemical effects of noradrenergic depletions with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine in 6-hydroxydopamine-induced rat model of Parkinson's disease
    J Srinivasan
    Zoological Institute, Neuropharmacology, University of Tuebingen, Auf der Morgenstelle 28E, 72076 Tuebingen, Germany
    Behav Brain Res 151:191-9. 2004
    ..These findings indicate the neuroprotective and symptomatic role of noradrenergic neurons. It implicates the importance of noradrenergic pathophysiology in Parkinson's disease and its treatment and need for a more relevant animal model...
  49. ncbi Pituitary adenylate cyclase activating polypeptide protects dopaminergic neurons and improves behavioral deficits in a rat model of Parkinson's disease
    Dora Reglodi
    Department of Anatomy, Pécs University Medical Faculty, Neurohumoral Regulations Research Group of the Hungarian Academy of Sciences, Szigeti u 12, 7624 Pecs, Hungary
    Behav Brain Res 151:303-12. 2004
    ..In summary, the present results show the neuroprotective effect of PACAP in 6-OHDA-induced lesion of substantia nigra, with less severe acute neurological symptoms and a more rapid amelioration of behavioral deficits...
  50. ncbi Molecular profiling of experimental Parkinson's disease: direct analysis of peptides and proteins on brain tissue sections by MALDI mass spectrometry
    Johan Pierson
    Laboratory for Biological and Medical Mass Spectrometry, Uppsala University, Box 583 Biomedicum, SE 75123, Sweden
    J Proteome Res 3:289-95. 2004
    ....
  51. ncbi Novel dopamine releasing response of an anti-convulsant agent with possible anti-Parkinson's activity
    M R Gluck
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neural Transm 111:713-24. 2004
    ..ZNS could therefore be a novel agent for the treatment of PD that could delay the use of or reduce the amount of levodopa needed to treat patients with PD...
  52. ncbi Survival and migration of transplanted neural stem cell-derived dopamine cells in the brain of parkinsonian rat
    Tae Beom Ahn
    Department of Neurology, Seoul National University College of Medicine, and Department of Neurology and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    Int J Neurosci 114:575-85. 2004
    ..Most TH+ cells had mature-looking polygonal shapes with processes. Some cells migrated into the striatum. Behavioral improvement was not seen..
  53. ncbi Electrophysiological characterization of substantia nigra dopaminergic neurons in partially lesioned rats: effects of subthalamotomy and levodopa treatment
    Gaizka Bilbao
    Department of Neurosurgery, Cruces Hospital E 48903, Bizkaia, Spain
    Brain Res 1084:175-84. 2006
    ..In this model, subthalamotomy does not modify the firing pattern while levodopa treatment efficiently restores normal firing of SNpc neurons and does not appear to be toxic to them...
  54. ncbi Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracellular striatal dopamine
    Wassilios Meissner
    Laboratoire de Physiologie et Physiopathologie de la Signalisation Cellulaire, CNRS UMR 5543, Universite Victor Segalen, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Neurobiol Dis 22:586-98. 2006
    ....
  55. ncbi Postnatal administration of D1 dopamine agonist reverses neonatal dopaminergic lesion-induced changes in striatal enkephalin and substance P systems
    Subbiah P Sivam
    Department of Pharmacology and Toxicology, Indiana University School of Medicine Northwest, 3400 Broadway, Gary, IN 46408, USA
    Brain Res 1073:159-63. 2006
    ..These studies are relevant to our further understanding of potential early interventions in the progression and expression of DA deficiency states such as Parkinsonism and Lesch-Nyhan disease...
  56. ncbi Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's disease
    Sara Gonzalez
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain
    Brain Res 1073:209-19. 2006
    ..Therefore, the elucidation of the neurochemical substrate involved in this effect remains a major challenge for the future...
  57. ncbi Effects of anaesthetics on the loss of nigrostriatal dopaminergic neurons by 6-hydroxydopamine in rats
    K P Datla
    Department of Cellular and Molecular Neuroscience, Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, Charing Cross Campus, London, United Kingdom
    J Neural Transm 113:583-91. 2006
    ..Thus, these results suggest that the extent of nigrostriatal dopaminergic neuronal loss with 6-OHDA seems to be influenced by anaesthetic used during the surgery...
  58. ncbi Chronic L-DOPA administration is not toxic to the remaining dopaminergic nigrostriatal neurons, but instead may promote their functional recovery, in rats with partial 6-OHDA or FeCl(3) nigrostriatal lesions
    K P Datla
    Parkinson's Disease Research Unit, Department of Neuroinflammation, Imperial College School of Medicine at Charing Cross Campus, Fulham Palace Road, London W6 8RF, United Kingdom
    Mov Disord 16:424-34. 2001
    ....
  59. ncbi Sonic hedgehog delivered by an adeno-associated virus protects dopaminergic neurones against 6-OHDA toxicity in the rat
    B Dass
    Neurodegenerative Diseases Research Centre, GKT School of Biomedical Sciences, King s College, London, United Kingdom
    J Neural Transm 112:763-78. 2005
    ..However, the effects maybe dose limited due to uncoupling of hedgehog receptor signalling at higher levels of SHH expression...
  60. pmc Phase relationships support a role for coordinated activity in the indirect pathway in organizing slow oscillations in basal ganglia output after loss of dopamine
    J R Walters
    Neurophysiological Pharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 3702, USA
    Neuroscience 144:762-76. 2007
    ....
  61. ncbi Role of corticostriatal and nigrostriatal inputs in malonate-induced striatal toxicity
    A Meldrum
    Centre for Brain Repair, Cambridge University, UK
    Neuroreport 12:89-93. 2001
    ..These data suggest that malonate-induced toxicity in the striatum depends upon the integrity of interactive influences from both glutamatergic and dopaminergic afferents...
  62. ncbi Role of nitric oxide in a progressive neurodegeneration model of Parkinson's disease in the rat
    M K Barthwal
    Pharmacology Division, Central Drug Research Institute, Lucknow, India
    Redox Rep 6:297-302. 2001
    ..Thus a possible role of nitric oxide in 6-OHDA induced neurodegeneration is suggested...
  63. ncbi [Transplantation of fetal dopaminergic cells simultaneously to the corpus striatum and pars reticularis of the substantia nigra in hemi-parkinsonian rats]
    L Blanco
    Grupo de Trastornos del Movimiento y EP, , CIREN, La Habana, Cuba
    Rev Neurol 26:361-5. 1998
    ..CONCLUSIONS: These results suggest a positive effect due to intrastriatal transplants compared to survival following intranigral transplants...
  64. ncbi Management of yellow oleander poisoning
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo 8, Sri Lanka
    Clin Toxicol (Phila) 47:206-12. 2009
    ..Accelerating the heart rate with atropine or beta-adrenergic agents theoretically increases the risk of tachyarrhythmias, and it has been claimed that atropine increases ..
  65. ncbi Hair analysis of seven bodybuilders for anabolic steroids, ephedrine, and clenbuterol
    V Dumestre-Toulet
    Laboratoire BIOffice, Artigues Pres Bordeaux, France
    J Forensic Sci 47:211-4. 2002
    ..3 to 4.8 ng/mg, n = 2). These results document the doping practice and demonstrate repetitive exposure to anabolic compounds and confirm the value of hair analysis as a complement to urinalysis in the control of doping practice...
  66. ncbi Adrenergic receptors on smooth muscle cells isolated from human penile corpus cavernosum
    P Costa
    Service d Urologie, C H U Gaston Doumergue, Nimes and Faculté de Pharmacie, Montpellier, France
    J Urol 150:859-63. 1993
    ..was examined on smooth muscle cells isolated from human corpus cavernosum, and compared with that of other adrenergic agents and papaverine...
  67. ncbi Drug-induced ocular disorders
    Junping Li
    Eye Clinic, VA Medical Center, Salem, VA, USA
    Drug Saf 31:127-41. 2008
    ..In addition, adrenergic agents, certain beta(2)-adrenergic agonists and anticholinergic agents may induce pupillary dilation and ..
  68. ncbi Cell signaling and ion transport across the fish gill epithelium
    David H Evans
    Department of Zoology, University of Florida, Gainesville, Florida 32611, USA
    J Exp Zool 293:336-47. 2002
    ..The gill epithelium may be affected by both circulating and local adrenergic agents, and a variety of studies have demonstrated that stimulation of alpha-adrenergic versus beta-adrenergic ..
  69. ncbi Sympathomimetic drug allergy: cross-reactivity study by patch test
    Ruth Barranco
    Allergy Unit, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Am J Clin Dermatol 5:351-5. 2004
    ..Cross-reactivity may exist among catecholamine derivatives, although reported data on this are contradictory. In this study, we investigate if there is cross-reactivity in patch tests among these drugs...
  70. ncbi Treatment of poisoning caused by beta-adrenergic and calcium-channel blockers
    Greene Shepherd
    Medical College of Georgia, 1120 15th Street, CJ 1020, Augusta, 30912 2450, USA
    Am J Health Syst Pharm 63:1828-35. 2006
    ..The toxic effects and treatment of beta-adrenergic blocker and calcium-channel blocker (CCB) overdose are reviewed...
  71. ncbi Management of calcium channel antagonist overdose
    Steven D Salhanick
    Children s Hospital, Boston, Massachusetts 02115, USA
    Drug Saf 26:65-79. 2003
    ..Supportive care including the use of phosphodiesterase inhibitors, adrenergic agents, cardiac pacing, balloon pump or extracorporeal bypass is frequently indicated if antidotal therapy is not ..
  72. ncbi Antibiotic administration to patients with preterm labor and intact membranes: is there a beneficial effect in patients with endocervical inflammation?
    Alfredo Ovalle
    Service and Department of Obstetrics, Gynecology and Neonatology, Hospital San Borja Arriaran, Faculty of Medicine, University of Chile, Santiago, Chile
    J Matern Fetal Neonatal Med 19:453-64. 2006
    ....
  73. ncbi Alpha-adrenergic stimulation of thermogenesis in a rat kangaroo (Marsupialia, Bettongia gaimardi)
    J M Ye
    Department of Biochemistry, University of Tasmania, Hobart, Australia
    Am J Physiol 271:R586-92. 1996
    ..examined the effect of alpha-adrenoceptors on the thermogenesis of conscious bettongs at rest by infusing adrenergic agents via an indwelling catheter in the tail vein. The resting Vo2 was 22.9 +/- 1.9 mmol.kg-1.h-1...
  74. ncbi Technetium-99m labeled 1-(4-fluorobenzyl)-4-(2-mercapto-2-methyl-4-azapentyl)-4-(2-mercapto-2-methylpropylamino)-piperidine and iodine-123 metaiodobenzylguanidine for studying cardiac adrenergic function: a comparison of the uptake characteristics in vasc
    Samuel Samnick
    Department of Nuclear Medicine, Saarland University Medical Centre, D 66421 Homburg, Germany
    Nucl Med Biol 31:511-22. 2004
    ..These data indicate that (99m)Tc-FBPBAT, like (123)I-MIBG, may be suitable for mapping cardiac adrenergic innervation by SPET, especially for alpha(1)/beta(1)-adrenoceptors as target in numerous heart diseases...
  75. ncbi Integrated acquisition of analytical and biopharmaceutical screening data for beta-adrenergic-drugs employing diversified macrocycle supported potentiometric detection in HPLC systems
    Grzegorz Bazylak
    Department of Chemistry, Faculty of Science Biomedicine, University of Antwerpen RUCA, Groenenborgerlaan 171, B 2020, Antwerpen, Belgium
    Curr Med Chem 9:1547-66. 2002
    ....
  76. ncbi The effects of simultaneous administration of alpha(2) -adrenergic agents with L-NAME or L-arginine on the development and expression of morphine dependence in mice
    M R Zarrindast
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, PO Box 13145 784, Tehran, Iran
    Behav Pharmacol 13:117-25. 2002
    ..In conclusion, alpha(2)-adrenergic and NO pathways seem to be functionally linked in the modulation of opioid dependence...
  77. ncbi Rhabdomyolysis caused by tocolysis with oral ritodrine hydrochloride in a pregnant patient with myotonic dystrophy
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Japan
    Gynecol Obstet Invest 61:53-5. 2006
    ..Therefore, beta-adrenergic agents should be used with great care, especially for patients with myotonic dystrophy, because of these agents' ..
  78. ncbi Pharmacological therapy for glaucoma: a review
    P F Hoyng
    Netherlands Ophthalmic Research Institute, Amsterdam
    Drugs 59:411-34. 2000
    For some time the medical treatment of glaucoma has consisted of topical beta-blockers, adrenergic agents, miotics and oral carbonic anhydrase inhibitors (CAIs)...
  79. pmc Autonomic drugs and the accommodative system in rhesus monkeys
    Lisa A Ostrin
    University of Houston College of Optometry, 505 J Davis Armistead Bldg, Houston, TX 77204, USA
    Exp Eye Res 90:104-12. 2010
    ..Low dose echothiophate had significant effects on pupil diameter and resting refraction, with only small effects on the dynamics of the accommodative response...
  80. ncbi Effects of alpha-adrenergic agents on transient inward current in rabbit Purkinje fibers
    G R Ferrier
    Laboratory of Physiology, University of Leuven, Belgium
    J Mol Cell Cardiol 22:191-200. 1990
    Reported effects of alpha-adrenergic agents on oscillatory afterpotentials (OAP) are conflicting...
  81. ncbi beta-Adrenergics enhance brain extraction of levodopa
    Ergun Y Uc
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Mov Disord 17:54-9. 2002
    ..Thus, beta-adrenergic agonists might be useful in the treatment of patients with Parkinson's disease by enhancing delivery of L-dopa to the brain...
  82. ncbi Drug use in Estonia in 1994-1995: a follow-up from 1989 and comparison with two Nordic countries
    R A Kiivet
    University of Tartu, Department of Public Health, Estonia
    Eur J Clin Pharmacol 54:119-24. 1998
    ..To determine the patterns of drug use in Estonia for the years 1989 and 1994 1995, i.e. for the years before and after the pharmaceutical services in the country changed from a state monopoly to a competitive market...
  83. ncbi Characteristics of 125I-iodocyanopindolol binding to beta-adrenergic and serotonin-1B receptors of rat brain: selectivity of beta-adrenergic agents
    H Tsuchihashi
    Department of Pharmacology, Niigata College of Pharmacy, Japan
    Jpn J Pharmacol 52:195-200. 1990
    ..These results suggest that beta-adrenoceptor antagonists can bind to beta-adrenoceptors and 5HT1B-receptors...
  84. ncbi Use of sibutramine and other noradrenergic and serotonergic drugs in the management of obesity
    D H Ryan
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Endocrine 13:193-9. 2000
    ....
  85. ncbi (-)-Isoproterenol modulation of maxi-K(+) channel in nonpigmented ciliary epithelial cells through a G-protein gated pathway
    Bula J Bhattacharyya
    Department of Ophthalmology, Northwestern University Medical School, Chicago, IL 60611, USA
    Curr Eye Res 24:173-81. 2002
    b>Adrenergic agents decrease intraocular pressure by reducing aqueous humor secretion from ciliary epithelial cells...
  86. ncbi [Methylene blue: an effective therapeutic alternative for priapism induced by intracavernous injection of vasoactive agents]
    Francisco José Martínez Portillo
    Departamento de Urologia, Clínica Universitaria de Kiel, Universidad de Kiel, Alemania
    Arch Esp Urol 55:303-8. 2002
    ..This prompted us to assess the feasibility, the use and the effectiveness of MB in the treatment of priapism...
  87. ncbi Effects of topical adrenergic agents on tissue circulation in rabbit and human optic nerve head evaluated with laser speckle tissue circulation analyzer
    Y Tamaki
    Eye Clinic, Tokyo Metropolitan Geriatric Hospital, Japan
    Surv Ophthalmol 42:S52-63. 1997
    The effects of topical adrenergic agents on the tissue circulation of the optic nerve head (ONH) were studied in animal and human eyes with use of a laser speckle tissue circulation analyzer...
  88. ncbi [Drugs and drug abusers]
    J Schlatter
    Service Pharmacie Toxicologie, Centre Hospitalier Universitaire Jean Verdier, Avenue du 14 Juillet, F 93140 Bondy
    Presse Med 30:282-7. 2001
    ..Clinical signs of addiction and weaning are observed. OTHERS: Several other drug classes are used by abusers, including analgics, beta-adrenergic agents, nasal vasoconstrictors and corticosteroids.
  89. ncbi Effect of beta-adrenergic agents on intracellular potential of rabbit ciliary epithelium
    L Q Tang
    Department of Ophthalmology, Northwestern University Medical School, Chicago, IL 60611, USA
    Curr Eye Res 17:24-30. 1998
    To study the effects of beta-adrenergic agents on intracellular potential (Vm) of the isolated and intact rabbit ciliary epithelium.
  90. ncbi [A study on the effect of recruitment maneuver imposed on extravascular lung water in patients with acute respiratory distress syndrome]
    Zong yu Wang
    Department of Critical Care Medicine, Beijing University Third Hospital, Beijing 100191, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:604-8. 2009
    ..To investigate the possible effects of recruitment maneuver (RM) imposing on extravascular lung water (EVLW) in patients with acute respiratory distress syndrome (ARDS)...
  91. ncbi Tic disorders: when habit forming neural systems form habits of their own?
    J F Leckman
    Child Study Center, Department of Pediatrics, Yale University, New Haven, CT 06520 7900, USA
    Zhonghua Yi Xue Za Zhi (Taipei) 64:669-92. 2001
    ..Although ideal anti-tic therapies are not available, recently completed clinical trials with alpha-adrenergic agents and atypical neuroleptics are encouraging...
  92. ncbi [Potentiometric detection of beta-adrenolytic and beta-adrenergic drugs in HPLC systems]
    Grzegorz Bazylak
    Zakład Bromatologii, Wydział Farmaceutyczny, Collegium Medicum im Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu
    Postepy Hig Med Dosw (Online) 59:554-69. 2005
    ....
  93. ncbi Aminophylline in the treatment of acute asthma when beta 2-adrenergics and steroids are provided
    D G Murphy
    Department of Emergency Medicine, Cook County Hospital, Chicago
    Arch Intern Med 153:1784-8. 1993
    ..05). CONCLUSION: In the emergency department setting, aminophylline contributes no significant improvement in PEFR when beta 2-agonists and corticosteroids are being provided, while causing more side effects...
  94. pmc Chlorine gas inhalation: human clinical evidence of toxicity and experience in animal models
    Carl W White
    Pediatrics, National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA
    Proc Am Thorac Soc 7:257-63. 2010
    ..Up to 1% of exposed individuals die. Humidified oxygen and inhaled beta-adrenergic agents are appropriate therapies for victims with respiratory symptoms while assessments are underway...
  95. ncbi Adrenergic receptors in the nucleus accumbens shell differentially modulate dopamine and acetylcholine receptor-mediated turning behaviour
    Hiroko Ikeda
    Department of Pharmacology, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Eur J Pharmacol 554:175-82. 2007
    ..5, 5 microg), but again in an aspecific manner. It is concluded that alpha- and beta-adrenergic agents have an effect on accumbal acetylcholine receptor-mediated circling through a non-adrenergic mechanism...
  96. ncbi Direct enantiomeric resolution of some cardiovascular agents using synthetic polymers imprinted with (-)-S-timolol as chiral stationary phase by thin layer chromatography
    H Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, King Saud University, Riyadh, Saudi Arabia
    Pharmazie 57:169-71. 2002
    ..The method offers a rapid, sensitive and reliable method for quality control for these drugs...
  97. ncbi Effects of autonomic agents and chemical mediators on ion transport by canine tracheal epithelium
    K Sugahara
    Department of Anesthesiology, Kumamoto University Medical School, Japan
    Jpn J Physiol 39:421-8. 1989
    ..We investigated the abilities of adrenergic agents, cholinergic agents, and chemical mediators to modulate ion transport in canine tracheal epithelium, using ..
  98. ncbi [Successful treatment of polymedicamentous poisoning with metoprolol, diltiazem and cilazapril]
    Milan R Radovanović
    Klinicki centar Kragujevac, Centar za urgentnu medicinu, Srbija
    Vojnosanit Pregl 66:904-8. 2009
    ..However, even whit the application of these drugs, prompt measures of unspecific detoxication therapy and cardiopulmonary reanimation are crucial for survival of patients with severe poisoning...
  99. ncbi Simultaneous separation of eight beta-adrenergic drugs using titanium dioxide nanoparticles as additive in capillary electrophoresis
    Shanshan Zhou
    College of Chemistry, Beijing Normal University, Beijing, P R China
    Electrophoresis 29:2321-9. 2008
    ..The proposed method was successfully applied for the rapid CE determination of the frequently applied antihypertensive beta-blocking compounds atenolol, metoprolol, terbutaline, and propranolol in pharmaceutical tablets...
  100. ncbi Relationship between alpha-adrenoceptor occupancy and contractile response in rat vas deferens. Experimental and theoretical analysis
    A Diaz-Toledo
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias biologicas y de Recursos Naturales, Universidad de Concepcion, Chile
    Eur J Pharmacol 156:315-24. 1988
    ..0063 and 0.0056 respectively). The dose-response curves generated by the model for partial agonists were similar to the curves obtained experimentally in vitro...
  101. ncbi Class III antiarrhythmics in overdose. Presenting features and management principles
    E W Leatham
    Department of Cardiological Sciences, St George s Hospital Medical School, London, England
    Drug Saf 9:450-62. 1993
    ..Management is directed at controlling hypotension with volume expansion and norepinephrine (noradrenaline)...

Research Grants62

  1. Antenatal Betamethasone in Late Preterm Gestation Lambs
    SATYANARAYANA LAKSHMINRUSIMHA; Fiscal Year: 2010
    ..We will study the changes in important mediators of pulmonary transition at birth such as nitric oxide, beta adrenergic agents, natriuretic peptides and prostaglandins secondary to antenatal glucocorticoid use...
  2. The regulation of adipocyte lipolysis by insulin
    MORRIS JAY BIRNBAUM; Fiscal Year: 2013
    ..used to convey the signal for increased lipolysis is cyclic AMP, which accumulates in reponse to beta-adrenergic agents and activates protein kinase A...
  3. Compound 49b prevents retinal endothelial cell apoptosis in type 2 diabetes
    Jena J Steinle; Fiscal Year: 2013
    ..Unfortunately, currently available adrenergic agents are associated with adverse systemic or non-specific effects...
  4. Compound 49b Prevents Retinal Endothelial Cell Death Through IGFBP-3 Levels
    Jena J Steinle; Fiscal Year: 2013
    ..Unfortunately, currently available adrenergic agents are associated with adverse systemic or non-specific effects...
  5. Preclinical test for the efficacy of adrenergic agents in treatment of AD
    Qin Wang; Fiscal Year: 2013
    ..The primary objective of this study is to determine the efficacy of adrenergic agents in delaying the onset and slowing the progression of AD using transgenic mouse models...
  6. ION DEREGULATION IN VIVO AND INJURY BY ALKYLATING DRUGS
    George Corcoran; Fiscal Year: 1990
    ....
  7. STIMULUS PROPERTIES OF COCAINE
    JAMES O DONNELL; Fiscal Year: 1990
    ..Moreover, these results may have clinical relevance for the pharmacological treatment of cocaine abuse...
  8. HORMONAL REGULATION OF ION CHANNELS IN MYOMETRIAL CELLS
    Enrico Stefani; Fiscal Year: 1993
    ..To explain the differences in activity of the uterus during these phases, the actions of adrenergic agents, oxytocin and prostaglandins on Ca and K channels and their mechanism(s) will be studied...
  9. OPIOID RECEPTOR CONSTANTS IN VITRO--TEMPERATURE
    Frank Porreca; Fiscal Year: 1990
    ..Knowledge of these fundamental opioid parameters should be instrumental in the process of rational drug design, particularly for antagonists...
  10. Adrenergic Receptors During Periadolescent Development
    David Bylund; Fiscal Year: 2005
    ..First, adrenergic agents are used clinically in children and adolescents...
  11. CARDIOVASCULAR EFFECTS OF COCAINE
    MARK KNUEPFER; Fiscal Year: 2001
    ..and sympathetic tone before and after cocaine and the possible causes of differential cardiac sensitivity to adrenergic agents. These studies will define causes of the CO and SVR variability...
  12. CEREBRAL BLOOD FLOW AND METABOLISM DURING INFANT CPR
    Charles Schleien; Fiscal Year: 1990
    ..These studies will add much to the clinical practice of CPR in infants. In addition, the CIA will provide experience and supervision which will facilitate the applicant's development as an effective and independent investigator...
  13. ALTERED FORCE KINETICS IN NORMAL AND STRESSED HEARTS
    Michael Berman; Fiscal Year: 1991
    Recently, calcium-independent enhancement of cardiac contractility by adrenergic agents has been reported...
  14. Ribosome Biogenesis: A Molecular Checkpoint for Cardiac Hypertrophy
    Lawrence Rothblum; Fiscal Year: 2009
    ..cis-acting elements of the UBF gene responsible for increased expression of the gene in response to either adrenergic agents or pressure overload...
  15. ISOQUINOLINE B3 AR AGONISTS AS ANTIOBESITY AGENTS
    DENNIS FELLER; Fiscal Year: 1999
    ..PROPOSED COMMERCIAL APPLICATION: A drug that is effective and safe for the treatment of obesity will have significant commercial success. ..
  16. CORTICOSTEROID EFFECT ON AIRWAY BETA-ADRENERGIC FUNCTION
    Craig Schramm; Fiscal Year: 1993
    ..This information, combined with independent observations that the airway's response to relaxant beta-adrenergic agents varies during post-natal development, raises two interrelates hypotheses: I...
  17. AMYGDALAR MODULATION OF BRAINSTEM ALERTING MECHANISMS
    LARRY SANFORD; Fiscal Year: 1999
    ..REM may also be disturbed in posttraumatic stress disorder, which is characterized by hypervigilance to unfamiliar stimuli and stereotypical anxiety dreams. ..
  18. ADRENERGIC CONTROL OF HEART & MUSCLE PHOSPHOFRUCTOKINASE
    TAG MANSOUR; Fiscal Year: 1990
    ..In spite of the expensive knowledge gained, the molecular details of the in vivo action of adrenergic agents on PFK to study the molecular and pharmacological events involved in activation of PFK by adrenergic agents...
  19. EFFECTIVENESS OF COUGH IN HEALTH AND DISEASE
    William Bennett; Fiscal Year: 1990
    ..These manipulations may include a) coughing with a denser gas mixture (SF6-02), B) use of beta- adrenergic agents, c) use of mucolytic agents, and d) water vapor inhalation...
  20. PHARMACOLOGY OF AQUEOUS HUMOR FORMATION
    Stephen Bartels; Fiscal Year: 1991
    ..Thus, glaucoma-related ocular hypertension can be medically managed and vision loss and surgery prevented...
  21. STUNNED HEART AND CARDIAC SURGERY:APOPTOSIS/NECROSIS
    Pedro del Nido; Fiscal Year: 2004
    ..Understanding of the mechanism of myocyte damage generated by ischemia/reperfusion and adrenergic drugs will Permit us to develop treatments to prevent this injury. ..
  22. OPIATE RECEPTOR INHIBITION IN CONGESTIVE HEART FAILURE
    Chang Seng Liang; Fiscal Year: 1992
    ..beta-endorphin, ACTH and catecholamines, baroreflex sensitivity, and inotropic left ventricular responses to adrenergic agents at the start and end of treatment...
  23. Methamphetamine Pharmacotherapy Development Center
    John Mendelson; Fiscal Year: 2009
    ..Our focused, mechanistically-based studies present opportunities for methods development and efficacy evaluations that could not be practically achieved without a collaborative center. ..
  24. CHLORIDE TRANSPORT IN HUMAN CILIARY EPITHELIUM
    Richard Crook; Fiscal Year: 2001
    ..The PI has reported that Na+, K+, Cl cotransport in ciliary epithelium is stimulated by B adrenergic agents and inhibited by timolol...
  25. Perilipiin and Lipolysis
    Andrew Greenberg; Fiscal Year: 2007
    ..Our adipocyte and systemic studies will measure basal lipolysis, lipolytic response to beta-adrenergic agents, and antilipolytic response to insulin...
  26. CATECHOLAMINE PHYSIOLOGY AND NEWBORN ADAPTATION
    James Padbury; Fiscal Year: 1991
    ..The clinical pharmacology of adrenergic agents in use in critically ill neonates will be studied with sensitive and specific hormone assays...
  27. REGULATION OF RAT RENAL INNER MEDULLARY FUNCTION
    JEFF SANDS; Fiscal Year: 1993
    ..is regulated by the protein content of the diet, and will test the effect of glucagon, glucocorticoids, and adrenergic agents on IMCD urea and water transport...
  28. A Novel Approach to Identify Smooth Muscle Relaxants
    JAMES HARTMAN; Fiscal Year: 2001
    ..In the latter class, inhaled Beta adrenergic agents are most commonly used but suffer from reduced efficacy with prolonged use secondary to receptor ..
  29. HISTAMINE ADRENERGICS AND SKELETAL MUSCLE ARTERIES
    LAURA MALLOY; Fiscal Year: 1991
    ..This study will enhance our understanding by identifying histaminergic mechanisms which contribute to control of vascular tone in skeletal muscle and which may be responsible for variations within the skeletal muscle bed. ..
  30. TRANSDERMAL TERBUTALINE FOR THE TREATMENT OF ASTHMA
    ANDREW TSUK; Fiscal Year: 1992
    ..Phase II will pursue FDA approval and commercialization of a practical transdermal TBS asthma treatment system...
  31. HETEROGENEITY OF ALPHA-2 ADRENERGIC RECEPTORS
    David Bylund; Fiscal Year: 1992
    ..These studies should help to resolve the present confusion in classification of alpha receptors and may lead to more selective alpha adrenergic drugs for clinical use...
  32. THE EFFECTS OF MODAFINIL ON FOOD INTAKE IN HUMANS
    Angela Makris; Fiscal Year: 2001
    ..However, unlike anorectic adrenergic agents, modafinil displays a low incidence of side effects. In addition, modafinil exhibits low abuse potential...
  33. RPE TRANSEPITHELIAL TRANSPORT
    DONALD FRAMBACH; Fiscal Year: 1992
    ..fetal human RPE transepithelial transport may be regulated by extracellular receptors (such as those to beta adrenergic agents) and to determine the degree to which cultured fetal human RPE transepithelial transport is affected by ..
  34. PSYCHOPHYSIOLOGY AND ANXIOGENESIS
    GARY BERNTSON; Fiscal Year: 2002
    ..Because anxiety disorders are often associated with abnormal autonomic regulation, they represent a clear risk factor for cardiovascular disease and sudden cardiac death. ..
  35. Sex, SLE, and Signal Transduction
    Jill Jacobson; Fiscal Year: 2005
    ..of stimulatory G proteins in females contributes to the increased responsiveness to GnRH, PTH, and beta-adrenergic agents in females compared to males...
  36. Brain derived TNF and Adrenergic Responses in Pain
    ROBERT SPENGLER; Fiscal Year: 2004
    ..Previously we have demonstrated that adrenergic agents can alter the neuroplastic responses to changes in TNF expression...
  37. Cav1.2 Transcript Regulation in Heart and Smooth Muscle
    Philip Palade; Fiscal Year: 2007
    ..b>Adrenergic agents are known to transcriptionally upregulate and then downregulate this channel in heart, but equivalent ..
  38. PROPRIOSPINAL CONNECTIONS
    Robert Skinner; Fiscal Year: 1980
    ..It will be possible to correlate the type of LDPT neuron, its peripheral field, and the phase of locomotion during which it is active. ..
  39. VASCULAR REACTIVITY IN NORMAL & HYPERTENSIVE PREGNANCIES
    RONALD MAGNESS; Fiscal Year: 1992
    ..on the reactivity of the systemic and uterine vascular beds to vasoconstriction by angiotensin 11 and alpha-adrenergic agents. Therefore, the long-term objectives of this project are to determine if the vascular alterations observed ..
  40. TOLERANCE TO OPIOID ACTIONS ON SENSORY NEURONS
    MICHAEL VASKO; Fiscal Year: 1993
    ..From these studies we will gain knowledge as to the sites and mechanisms by which opioids and alpha2-agonists produce antinociception and on the mechanisms of tolerance development...
  41. PROBLEMS IN EYE INFECTIONS
    Chandler Dawson; Fiscal Year: 1990
    ..The goal of this research is to examine local treatment with specific mediators for their potential to prevent or enhance recurrent herpetic eye disease in humans...
  42. HORMONAL REGULATION OF MITOCHONDRIAL FUNCTION
    RUSSELL YAMAZAKI; Fiscal Year: 1980
    ..Cellular calcium movements as affected by alpha-adrenergic agents, vasopressin, and glucagon will be studied.
  43. FUNCTIONAL ASSAY SYSTEMS FOR HUMAN ADRONERGIC RECEPTORS
    Carlos Forray; Fiscal Year: 1992
    ..In Phase II, the program will be expanded to encompass the remaining human a1 receptor subtypes and a broader array of tissues, cell lines and G-proteins...
  44. BULBOSPINAL MECHANISMS INVOLVED IN MORPHINE ANALGESIA
    HERBERT PROUDFIT; Fiscal Year: 1980
    ..nuclei and ascertaining the effects on raphe magnus neurons; (4) microinjecting cholinergic and adrenergic agents into the raphe magnus to ascertain the influence of modifying cholinergic and adrenergic neurotransmission ..
  45. EXPRESSION AND MUTAGENESIS OF CLONED ALPHA2-RECEPTORS
    LEE LIMBIRD; Fiscal Year: 1999
    ..the structural basis for many of the functional properties of alpha2-receptors and perhaps suggest novel loci for drug development in mimicking, or blocking, the effects of alpha2-adrenergic agents in particular physiological processes.
  46. Prion Transport Across the Blood-Brain Barrier
    William Banks; Fiscal Year: 2009
    ..To cause disease, prions must cross the blood-brain barrier to enter the brain. We will determine how prions cross the BBB. Knowing how prions enter the brain should lead to strategies on how to prevent prion diseases. ..
  47. PTS1 Regulation of Brain Met Enk Levels in Alcoholism
    William Banks; Fiscal Year: 2004
    ..abstract_text> ..
  48. Opiate Addiction and HIV-1 Induced Release of Cytokines
    William Banks; Fiscal Year: 2006
    ....
  49. Mechanisms of HIV Transport Across the BBB
    William Banks; Fiscal Year: 2004
    ....
  50. ROLE OF ACETALDEHYDE IN CENTRAL ACTIONS OF ETHANOL
    Richard Deitrich; Fiscal Year: 2002
    ..In addition, we now have acatalasemic mice as well as Cytochrome P450 2EI knockout mice. Since both catalase and this cytochrome have been implicated in ethanol oxidation, these knockout mice will be especially useful. ..
  51. NEUROENDOCRINE CONTROL OF REPRODUCTIVE BEHAVIOR
    LAUREN RITERS; Fiscal Year: 2003
    ..In addition, this research could lay the groundwork for future studies on the etiology of disorders related to sexual arousal...
  52. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2004
    ....
  53. Investigation of Dopamine Function In Human Amygdala
    LAWRENCE CAHILL; Fiscal Year: 2004
    ..The data derived from these preliminary experiments should lay the foundation for a research program aimed at understanding how DA mechanisms within the human amygdala subserve both emotional memory and addiction. ..
  54. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2010
    ..This proposal, by testing the efficacy of carvedilol and investigating the influence of withdrawal severity on carvedilol's efficacy, may result in development of more effective treatments for cocaine addiction. ..
  55. Estrogen, Stress and Dysfunction of Prefrontal Cortex
    Amy Arnsten; Fiscal Year: 2005
    ..This research will begin to reveal how estrogen amplifies the neurochemical cascades that lead to activation of CREB and dysfunction of the PFC during stress ..
  56. Ginkgo Biloba: Antidepressant-Induced Sexual Dysfunction
    Cindy Meston; Fiscal Year: 2003
    ..If effective, GBE could play a significant adjunctive role in the treatment of clinical depression and other psychological disorders commonly treated with antidepressant medications. ..
  57. AMPHETAMINE, INSULIN AND THE DA TRANSPORTER IN VIVO
    Lynette Daws; Fiscal Year: 2005
    ..In turn, these studies may help to illuminate the neural mechanisms underlying the high co-morbidity of eating disorders and drug abuse. ..
  58. Louisiana Clinical and Translational Science Center Planning Phase
    Donna Ryan; Fiscal Year: 2006
    ..In addition to activities serving Louisiana, the LA CaTS Center will serve as an incubator to foster the development of innovative tools and information technologies that can benefit the field. [unreadable] [unreadable] [unreadable]..
  59. NEUROBIOLOGICAL MECHANISMS OF DIENCEPHALIC AMNESIA
    Robert Mair; Fiscal Year: 2002
    ..Finally, lesions of the projection targets (prefrontal cortex and hippocampus) will be compared with results indicating that ILn lesions (similar to Korsakoff's disease) cause a slowing of reaction time in a serial reaction task. ..