Genomes and Genes
Summary: Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
Publications306 found, 100 shown here
- New insights into neuron-glia communicationR Douglas Fields
Neurocytology and Physiology Section, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Science 298:556-62. 2002..By releasing neurotransmitters and other extracellular signaling molecules, glia can affect neuronal excitability and synaptic transmission and perhaps coordinate activity across networks of neurons...
- The synaptic vesicle cycleThomas C Sudhof
Center for Basic Neuroscience, Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA Thomas
Annu Rev Neurosci 27:509-47. 2004..The present review attempts to relate these molecular data with physiological results in an emerging view of nerve terminals as macromolecular machines...
- Hippocampal short- and long-term plasticity are not modulated by astrocyte Ca2+ signalingCendra Agulhon
Department of Pharmacology, University of North Carolina at Chapel Hill, Genetic Medicine Building, CB 7365, Chapel Hill, NC 27599, USA
Science 327:1250-4. 2010..Our findings suggest that, at least in the hippocampus, the mechanisms of gliotransmission need to be reconsidered...
- Released fraction and total size of a pool of immediately available transmitter quanta at a calyx synapseR Schneggenburger
Max Planck Institut fur biophysikalische Chemie, Abteilung Membranbiophysik, Gottingen, Germany
Neuron 23:399-409. 1999..The results reveal a surprisingly large pool of functionally available vesicles, of which a fraction of about 0.2 is released by a single presynaptic action potential under physiological conditions...
- Descending control of painMark J Millan
Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy Seine, Paris, France
Prog Neurobiol 66:355-474. 2002..Knowledge of descending pathways has increased exponentially in recent years, so this is an opportune moment to survey their operation and therapeutic relevance to the improved management of pain...
- Essential functions of synapsins I and II in synaptic vesicle regulationT W Rosahl
Department of Molecular Genetics, University of Texas Southwestern Medical School, Dallas 75235, USA
Nature 375:488-93. 1995....
- CDK5 serves as a major control point in neurotransmitter releaseSung Hyun Kim
Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA
Neuron 67:797-809. 2010..These studies thus pinpoint CDK5 as a major control point for modulation of neurotransmitter release in mammalian neurons...
- Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?Alexander M Walter
Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam and VU Medical Center, 1081 HV Amsterdam, The Netherlands
Trends Neurosci 34:487-97. 2011....
- Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transportersAtsuko Yamashita
Department of Biochemistry and Molecular Biophysics and
Nature 437:215-23. 2005..The structure reveals the architecture of this important class of transporter, illuminates the determinants of substrate binding and ion selectivity, and defines the external and internal gates...
- Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activityN R Sibson
Department of Molecular Biophysics, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 95:316-21. 1998..Another implication of this result is that brain activation studies, which map cortical oxidative Glc metabolism, provide a quantitative measure of synaptic glutamate release...
- RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zoneSusanne Schoch
The Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
Nature 415:321-6. 2002..These data indicate that RIM1alpha has a central function in integrating active zone proteins and synaptic vesicles into a molecular scaffold that controls neurotransmitter release...
- The calyx of HeldRalf Schneggenburger
Laboratory of Synaptic Mechanisms, Ecole Polytechnique Federale de Lausanne EPFL, Brain Mind Institute, Bâtiment AAB, Station 15, CH 1015 Lausanne, Switzerland
Cell Tissue Res 326:311-37. 2006..Together, these studies convey the panopoly of presynaptic regulatory processes underlying the regulation of transmitter release, its modulatory control and short-term plasticity within one identified synaptic terminal...
- Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous releaseAnton Maximov
Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Neuron 48:547-54. 2005..We propose that synaptotagmin 1 occupies release "slots" at the active zone, possibly in a Ca(2+)-independent complex with SNARE proteins that are freed when action potential-induced Ca(2+) influx activates synaptotagmin 1...
- Synaptotagmin I synchronizes transmitter release in mouse hippocampal neuronsTei ichi Nishiki
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 24:6127-32. 2004..Thus, synaptotagmin I synchronizes the rapid release of neurotransmitters after Ca2+ entry into presynaptic terminals and also appears to suppress the slower, asynchronous form of transmitter release...
- Beyond the wiring diagram: signalling through complex neuromodulator networksVladimir Brezina
Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
Philos Trans R Soc Lond B Biol Sci 365:2363-74. 2010....
- Hydrogen sulfide protects neurons against hypoxic injury via stimulation of ATP-sensitive potassium channel/protein kinase C/extracellular signal-regulated kinase/heat shock protein 90 pathwayA S Tay
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 18 Medical Drive, Singapore
Neuroscience 167:277-86. 2010..Our findings emphasize the important neuroprotective role of H(2)S in the brain during cerebral hypoxia...
- Neurobiology of gambling behaviorsMarc N Potenza
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Curr Opin Neurobiol 23:660-7. 2013..Considerations for future directions in gambling research, with a view towards translating neurobiological advances into more effective prevention and treatment strategies, are discussed. ..
- Spillover-mediated feedforward inhibition functionally segregates interneuron activityLuke T Coddington
Department of Neurobiology and Evelyn McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Neuron 78:1050-62. 2013..These data demonstrate how glutamate release from single CFs modulates excitability of neighboring PCs, thus expanding the influence of CFs on cerebellar cortical activity in a manner not predicted by anatomical connectivity. ..
- Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter releaseAlexandra P Few
Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 109:E452-60. 2012....
- Reconstruction of aperture functions during full fusion in vesicular exocytosis of neurotransmittersChristian Amatore
Departement de Chimie, Ecole Normale Superieure, UMR CNRS ENS UPMC 8640 PASTEUR, 24 rue Lhomond, 75231 Paris Cedex 05, France
Chemphyschem 11:159-74. 2010..Yet, a statistical analysis establishes that this maximum aperture angle is most probably less than a few tens of degrees, which suggests that full fusion is a very improbable event...
- α2δ expression sets presynaptic calcium channel abundance and release probabilityMichael B Hoppa
Department of Biochemistry, Weill Cornell Medical College, New York, New York 10023, USA
Nature 486:122-5. 2012..Our data reveal dual functionality of these clinically important VGCC subunits, allowing synapses to make more efficient use of Ca(2+) entry to drive neurotransmitter release...
- Tyramine as an independent transmitter and a precursor of octopamine in the locust central nervous system: an immunocytochemical studyNatalia L Kononenko
Freie Universitat Berlin, Institute of Biology, Neurobiology, D 14195 Berlin, Germany
J Comp Neurol 512:433-52. 2009..We conclude that tyramine is an independent transmitter in locusts, and that in octopaminergic neurons the ratio between octopamine and its precursor tyramine is highly dynamic...
- High-throughput analysis of calcium signalling kinetics in astrocytes stimulated with different neurotransmittersLaura R James
Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, United Kingdom
PLoS ONE 6:e26889. 2011..We conclude that the time course of global intracellular Ca(2+) signals does not offer the cells a means for distinguishing between different neurotransmitters...
- Astrocytic control of glutamatergic activity: astrocytes as stars of the showLeif Hertz
College of Basic Medical Sciences, China Medical University, Shenyang, P R China
Trends Neurosci 27:735-43. 2004....
- Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosisMingshan Xue
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
Neuron 64:367-80. 2009....
- SV2 acts via presynaptic calcium to regulate neurotransmitter releaseQun Fang Wan
The Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, TX 77030, USA
Neuron 66:884-95. 2010..Thus, SV2 controls key aspects of synaptic functionality via its ability to regulate presynaptic Ca(2+), suggesting a potential new target for therapeutic intervention in the treatment of epilepsy...
- Selective stimulation of astrocyte calcium in situ does not affect neuronal excitatory synaptic activityTodd A Fiacco
Department of Pharmacology, 1004 Mary Ellen Jones Building CB 7365, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7365, USA
Neuron 54:611-26. 2007..Our findings call into question the developing consensus that Ca(2+)-dependent glutamate release by astrocytes directly affects neuronal synaptic activity in situ...
- Review on the influence of stress on immune mediators, neuropeptides and hormones with relevance for inflammatory bowel diseaseJ H Niess
Biomedizinisches Forschungszentrum, Campus Virchow Klinikum, Berlin, Germany
Digestion 65:131-40. 2002..e. neurotransmitters, hormones and immune cells, which are involved in the response to stress on the one hand, and contribute to the onset, progression or relapses of IBD on the other...
- Reduced anxiety-like behavior and central neurochemical change in germ-free miceK M Neufeld
Brain Body Institute, St Joseph s Healthcare, Hamilton, ON, Canada
Neurogastroenterol Motil 23:255-64, e119. 2011..For example, the presence of gut microbiota regulates the set point for hypothalamic-pituitary-adrenal (HPA) axis activity...
- Uptake of botulinum neurotoxin into cultured neuronsJames E Keller
Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Biochemistry 43:526-32. 2004..This study demonstrates that uptake of both BoNT-A and -E is enhanced with synaptic activity and that translocation of the toxin catalytic moiety into the cytosol occurs at different rates for these two serotypes...
- Suicide neurobiologyCarl Ernst
McGill Group for Suicide Studies, McGill University, Montreal, Quebec, Canada
Prog Neurobiol 89:315-33. 2009....
- Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter releaseJun Yao
Howard Hughes Medical Institute and Department of Neuroscience, University of Wisconsin, Madison, WI 53706, USA
Cell 147:666-77. 2011..In summary, we propose that Doc2 is a Ca(2+) sensor that is kinetically tuned to regulate asynchronous neurotransmitter release...
- Neurotransmitter-mediated calcium signalling in oligodendrocyte physiology and pathologyArthur M Butt
School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom
Glia 54:666-75. 2006..A key issue for future studies is to determine the physiological roles of neurotransmitters in mature oligodendrocytes and NG2-glia (synantocytes)...
- Distinct roles of different neural cell adhesion molecule (NCAM) isoforms in synaptic maturation revealed by analysis of NCAM 180 kDa isoform-deficient miceLuis Polo-Parada
Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4975, USA
J Neurosci 24:1852-64. 2004..Together, these results indicate that different isoforms of NCAM mediate distinct and important events in presynaptic maturation...
- Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesityJ Hara
Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
Neuron 30:345-54. 2001..Orexin/ataxin-3 mice provide a valuable model for studying the pathophysiology and treatment of narcolepsy...
- Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapseM Geppert
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
Cell 79:717-27. 1994..We propose that synaptotagmin I is the major low affinity Ca2+ sensor mediating Ca2+ regulation of synchronous neurotransmitter release in hippocampal neurons...
- Activity-dependent homeostatic specification of transmitter expression in embryonic neuronsLaura N Borodinsky
Neurobiology Section, Division of Biological Sciences and Center for Molecular Genetics, UCSD, La Jolla, California 92093 0357, USA
Nature 429:523-30. 2004..The results identify a new role of patterned activity in development of the central nervous system...
- Review of recent advances in analytical techniques for the determination of neurotransmittersMaura Perry
University of Michigan, Department of Chemistry, 930 N University, Ann Arbor, MI 48109 1055, USA
Anal Chim Acta 653:1-22. 2009..Advances in application to catecholamines, indoleamines, and amino acids have been prominent. Improvements in stability, sensitivity, and selectivity of the sensors have been of paramount interest...
- The antidepressant-sensitive dopamine transporter in Drosophila melanogaster: a primordial carrier for catecholaminesP Porzgen
Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
Mol Pharmacol 59:83-95. 2001..The identification of a cocaine-sensitive target linked to dopaminergic neurotransmission in D. melanogaster will serve as a basis for further dissection of the genetic components of psychostimulant-mediated behavior...
- Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugsTodd D Gould
Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, MD 20892, USA
Neuropsychopharmacology 30:1223-37. 2005..In this regard, as is discussed, there is a major effort underway to develop novel, specific, GSK-3 inhibitors...
- ATP signaling is crucial for communication from taste buds to gustatory nervesThomas E Finger
Rocky Mountain Taste and Smell Center, Aurora CO 80045, USA
Science 310:1495-9. 2005..Finally, stimulation of taste buds in vitro evokes release of ATP. Thus, ATP fulfils the criteria for a neurotransmitter linking taste buds to the nervous system...
- Flame etching enhances the sensitivity of carbon-fiber microelectrodesAndrew M Strand
Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904 4319, USA
Anal Chem 80:3708-15. 2008..The small flame-etched electrodes will facilitate measurements of low concentrations in discrete brain regions or small organisms...
- Neurotransmitter receptors in the life and death of oligodendrocytesR Karadottir
Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
Neuroscience 145:1426-38. 2007..Here we review the roles of neurotransmitter receptors in the normal function, and malfunction in pathological conditions, of oligodendrocytes...
- Selective capability of SynCAM and neuroligin for functional synapse assemblyYildirim Sara
Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
J Neurosci 25:260-70. 2005..These results suggest that both NL1 and SynCAM act similarly and specifically in artificial synapse induction but that this process does not reflect a shared physiological function of these molecules...
- Cellular excitability and the regulation of functional neuronal identity: from gene expression to neuromodulationDavid J Schulz
Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA
J Neurosci 26:10362-7. 2006
- Effects of chronic restraint stress and estradiol on open field activity, spatial memory, and monoaminergic neurotransmitters in ovariectomized ratsR E Bowman
Department of Psychology, Hunter College of the City University of New York, 695 Park Avenue, New York, NY 10021, USA
Neuroscience 113:401-10. 2002..Results show that estradiol may moderate stress effects on cognition and anxiety through both organizational and activation effects...
- Functional and chemical anatomy of the afferent vagal systemH R Berthoud
Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
Auton Neurosci 85:1-17. 2000..Furthermore, these functions are in line with a general defensive character ascribed to the vagal afferent, paraventricular system in lower vertebrates...
- Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous systemJohn A Dani
Department of Neuroscience, Program of Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
Annu Rev Pharmacol Toxicol 47:699-729. 2007..Decline, disruption, or alterations of nicotinic cholinergic mechanisms contribute to dysfunctions such as epilepsy, schizophrenia, Parkinson's disease, autism, dementia with Lewy bodies, Alzheimer's disease, and addiction...
- Functional groups modulate the sensitivity and electron transfer kinetics of neurochemicals at carbon nanotube modified microelectrodesChristopher B Jacobs
Dept of Chemistry, University of Virginia, P O Box 400319, Charlottesville, VA 22904, USA
Analyst 136:3557-65. 2011..The functional groups of CNTs therefore modulate the electrochemical properties, and the increase in sensitivity from CNT modification facilitates measurements in biological samples...
- Substantial changes in central nervous system neurotransmitters and neuromodulators accompany phase change in the locustStephen M Rogers
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
J Exp Biol 207:3603-17. 2004..Our data show that changes in levels of neuroactive substances are widespread in the central nervous system and reflect the time course of behavioural and physiological phase change...
- Synapsin II and calcium regulate vesicle docking and the cross-talk between vesicle pools at the mouse motor terminalsWilliam L Coleman
Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
J Physiol 586:4649-73. 2008..The results of the modelling were in a good agreement with the observed dependence of vesicle distribution on synapsin II and calcium deficiency...
- Neurotransmitter receptors on microgliaJennifer M Pocock
Cell Signalling Laboratory, Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
Trends Neurosci 30:527-35. 2007..Understanding how microglia respond to different neurotransmitters will thus have important implications for controlling the reactivity of these cells in acute injury, as well as for treating chronic neurodegenerative diseases...
- Impact of gestational and lactational phthalate exposure on hypothalamic content of amino acid neurotransmitters and FSH secretion in peripubertal male ratsSilvia Carbone
Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires, Argentina
Neurotoxicology 31:747-51. 2010..This could be related with the gonadotropin modifications also here described...
- Synaptic assembly of the brain in the absence of neurotransmitter secretionM Verhage
Molecular Neuroscience, Rudolf Magnus Institute, University of Utrecht Medical Centre, Utrecht, Netherlands
Science 287:864-9. 2000..Thus, synaptic connectivity does not depend on neurotransmitter secretion, but its maintenance does. Neurotransmitter secretion probably functions to validate already established synaptic connections...
- SV2 regulates neurotransmitter release via multiple mechanismsAmy Nowack
Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
Am J Physiol Cell Physiol 299:C960-7. 2010..These results indicate that SV2 performs at least two actions at the synapse that contribute to neurotransmitter release...
- Serotonin involvement in the metamorphosis of the hydroid Eudendrium racemosumGiuliana Zega
Dipartimento di Biologia, Sez Zoologia S N, Universit Statale di Milano, Milan, Italy
Int J Dev Biol 51:307-13. 2007..Results from this work showed that 5-HT could stimulate metamorphosis in E. racemosum planulae in the presence of a natural inducer. A mechanism by which this neurotransmitter could act in this phase is proposed...
- Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporterAli El-Kasaby
Institute of Pharmacology, Center of Physiology and Pharmacology, Medical University of Vienna, Währinger Str 13a, A 1090 Vienna, Austria
J Biol Chem 285:39201-10. 2010....
- How does synaptotagmin trigger neurotransmitter release?Edwin R Chapman
Howard Hughes Medical Institute and Department of Physiology, University of Wisconsin, Madison, WI 53706, USA
Annu Rev Biochem 77:615-41. 2008..This work sheds light not only on presynaptic aspects of synaptic transmission, but also on the fundamental problem of membrane fusion, which has remained a puzzle that has yet to be solved in any biological system...
- Identification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neuronsYu Jin Won
1Section on Transmitter Signaling, Laboratory of Molecular Physiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9411, USA
J Neurophysiol 105:442-53. 2011..These results provide the basis for using the zebrafish model system to understanding Ca(2+) channel function, and in turn, how Ca(2+) channels contribute to mechanosensory function...
- A small number of open Ca2+ channels trigger transmitter release at a central GABAergic synapseIancu Bucurenciu
Institute of Physiology I, Universitat Freiburg, Freiburg, Germany
Nat Neurosci 13:19-21. 2010..Furthermore, a small number of Ca(2+) channels were able to evoke release with high temporal precision, despite stochastic Ca(2+) channel opening...
- Deleterious effects in mice of fish-associated methylmercury contained in a diet mimicking the Western populations' average fish consumptionJean Paul Bourdineaud
Bordeaux University CNRS, UMR EPOC 5805, Arcachon Marine Station, Place du Docteur Peyneau, Arcachon, 33120, France
Environ Int 37:303-13. 2011....
- Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesisKazuhiro Tokuda
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 30:16788-95. 2010..Thus, dual activation of CBRs and TSPO appears to result in unique actions of clinically important BDZs. Furthermore, endogenous neurosteroids are shown to be important regulators of pyramidal neuron function and synaptic plasticity...
- P2Y nucleotide receptors: promise of therapeutic applicationsKenneth A Jacobson
Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Drug Discov Today 15:570-8. 2010..On the horizon are novel treatments for cardiovascular diseases, inflammatory diseases and neurodegeneration...
- Bidirectional regulation of thermotaxis by glutamate transmissions in Caenorhabditis elegansNoriyuki Ohnishi
Laboratory of Molecular Neurobiology, Division of Biological Science, Department of Molecular Biology, Graduate School of Science, Nagoya University, Nagoya, Aichi, Japan
EMBO J 30:1376-88. 2011..We thus provide an important insight on information processing, in which two glutamate transmissions encoding opposite information flows regulate neural activities to produce a large spectrum of behavioural outputs...
- Contralateral high or a combination of high- and low-frequency transcutaneous electrical nerve stimulation reduces mechanical allodynia and alters dorsal horn neurotransmitter content in neuropathic ratsDavid L Somers
Department of Physical Therapy, John G Rangos Sr School of Health Sciences, Duquesne University, Pittsburgh, Pennsylvania, USA
J Pain 10:221-9. 2009..The present findings support a contralateral approach to the application of TENS and suggest that distinct strategies for TENS application may differentially alter neurotransmission in the central nervous system...
- cJun integrates calcium activity and tlx3 expression to regulate neurotransmitter specificationKurt W Marek
Neurobiology Section, Division of Biological Sciences and Center for Neural Circuits, Kavli Institute for Brain and Mind, University of California San Diego, La Jolla, California, USA
Nat Neurosci 13:944-50. 2010..This mechanism provides a basis for early activity to regulate genetic pathways at critical decision points, switching the phenotype of developing neurons...
- GABA, its receptors, and GABAergic inhibition in mouse taste budsGennady Dvoryanchikov
Department of Physiology and Biophysics and Program in Neuroscience, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
J Neurosci 31:5782-91. 2011..We conclude that GABA is an inhibitory transmitter released during taste stimulation and possibly also during growth and differentiation of taste buds...
- The molecular biology of memory storage: a dialogue between genes and synapsesE R Kandel
Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
Science 294:1030-8. 2001....
- The timing of phasic transmitter release is Ca2+-dependent and lacks a direct influence of presynaptic membrane potentialFelix Felmy
AG Synaptische Dynamik und Modulation and Abteilung Membranbiophysik, Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, D 37077 Gottingen, Germany
Proc Natl Acad Sci U S A 100:15200-5. 2003....
- Monoamine neurotransmitters as substrates for novel tick sulfotransferases, homology modeling, molecular docking, and enzyme kineticsEmine Bihter Yalcin
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, United States
ACS Chem Biol 6:176-84. 2011....
- Neurotransmitter receptors as central regulators of pancreatic cancerHildegard M Schuller
Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
Future Oncol 6:221-8. 2010..Accordingly, PDAC intervention strategies should include the diagnosis of unphysiological neurotransmitter levels and aim to restore any imbalance in stimulatory and inhibitory neurotransmitters...
- Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter releaseJ T Littleton
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
Cell 74:1125-34. 1993..These results provide in vivo evidence that syt plays a key role in Ca2+ activation of neurotransmitter release and indicate the existence of separate pathways for evoked and spontaneous neurotransmitter release...
- Multiple roles of calcium ions in the regulation of neurotransmitter releaseErwin Neher
Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
Neuron 59:861-72. 2008..Such coupling is essential for rendering vesicles sensitive to short [Ca(2+)] transients, generated during action potentials...
- The binomial model in fluctuation analysis of quantal neurotransmitter releaseD M Quastel
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada
Biophys J 72:728-53. 1997....
- The probability of neurotransmitter release: variability and feedback control at single synapsesTiago Branco
Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, WC1E 6BT, UK
Nat Rev Neurosci 10:373-83. 2009..This local tuning of transmission has important implications for current models of single-neuron computation...
- Neurotransmitter properties of spinal interneurons in embryonic and larval zebrafishShin Ichi Higashijima
Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, New York 11794 5230, USA
J Comp Neurol 480:19-37. 2004..Our approach allowed us to define the likely transmitter phenotypes of most of the known classes of spinal interneurons. These data provide a foundation for understanding the functional organization of the spinal networks in zebrafish...
- The low synaptic release probability in vivoJ Gerard G Borst
Department of Neuroscience, Erasmus MC, University Medical Center Rotterdam, 3015 GE Rotterdam, The Netherlands
Trends Neurosci 33:259-66. 2010..Existing evidence thus suggests that under physiological conditions in vivo, presynaptic action potentials trigger the release of neurotransmitter much less frequently than what is observed in in vitro preparations...
- Cellular, synaptic and network effects of neuromodulationEve Marder
Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454 9110, USA
Neural Netw 15:479-93. 2002..Some of the computational consequences of these features of modulator action are discussed...
- PACAP potentiates L-type calcium channel conductance in suprachiasmatic nucleus neurons by activating the MAPK pathwayHeather Dziema
Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
J Neurophysiol 88:1374-86. 2002..The data presented here identify potentially important mechanisms by which PACAP regulates SCN physiology...
- RIM1alpha is required for presynaptic long-term potentiationPablo E Castillo
Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94304, USA
Nature 415:327-30. 2002....
- Light-induced phase shift in the Syrian hamster (Mesocricetus auratus) is attenuated by the PACAP receptor antagonist PACAP6-38 or PACAP immunoneutralizationA L Bergström
Department of Clinical Biochemistry, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
Eur J Neurosci 18:2552-62. 2003..The findings indicate that PACAP is a neurotransmitter of the RHT mediating photic information to the clock, possibly via melanopsin located exclusively on the PACAP-expressing cells of the RHT...
- Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systemsS A Deuchars
School of Biomedical Sciences, University of Leeds, LS2 9NQ, Leeds, United Kingdom
J Neurosci 21:7143-52. 2001..Such a widespread distribution and functional role suggests that the receptor may be involved in the fundamental regulation of synaptic transmission at the presynaptic site...
- Malignant gliomas: perverting glutamate and ion homeostasis for selective advantageHarald Sontheimer
Department of Neurobiology and Civitan International Research Center, The University of Alabama at Birmingham, Birmingham, AL 35244, USA
Trends Neurosci 26:543-9. 2003..Recent research suggests that astrocyte-derived tumors co-opt neurotransmitters, their transporters and ion channels to support their unusual growth and invasive migration...
- Asynchronous transmitter release from cholecystokinin-containing inhibitory interneurons is widespread and target-cell independentMichael I Daw
Program in Developmental Neuroscience, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 29:11112-22. 2009....
- Neurotransmitters and prefrontal cortex-limbic system interactions: implications for plasticity and psychiatric disordersAlberto Del Arco
Department of Physiology, Faculty of Medicine, Universidad Complutense, Madrid, Spain
J Neural Transm 116:941-52. 2009..Finally, it is speculated that changes in the function of the PFC, associated with psychiatric disorders or due to environmental-dependent plasticity, can change PFC-limbic system interactions...
- The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusionM Geppert
Max Planck Institute for Experimental Medicine, Gottingen, Germany
Nature 387:810-4. 1997....
- Neuromodulation intrinsic to the central pattern generator for escape swimming in TritoniaP S Katz
Department of Biology, Georgia State University, Atlanta 30302, USA
Ann N Y Acad Sci 860:181-8. 1998..These neuromodulatory actions intrinsic to the CPG may be important for the initial self-configuration of the system into a function CPG and for experience-dependent changes in the output such as behavioral sensitization and habituation...
- A review of neurohormone GPCRs present in the fruitfly Drosophila melanogaster and the honey bee Apis melliferaFrank Hauser
Center for Functional and Comparative Insect Genomics, Department of Cell Biology and Comparative Zoology, Institute of Biology, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
Prog Neurobiol 80:1-19. 2006..This is in contrast to biogenic amine GPCRs, where evolutionarily unrelated GPCRs often bind to the same biogenic amine, suggesting frequent ligand exchanges ("ligand hops") during GPCR evolution...
- Monitoring rapid chemical communication in the brainDonita L Robinson
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3290, USA
Chem Rev 108:2554-84. 2008
- Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter releaseAlexander J Groffen
Department of Functional Genomics, CNCR, Neuroscience Campus Amsterdam, VU University and VU Medical Center, Amsterdam, 1081 HV, Netherlands
Science 327:1614-8. 2010....
- N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous systemJ H Neale
Department of Biology, Georgetown University, Washington, D C, USA
J Neurochem 75:443-52. 2000..A second role is the production of extracellular glutamate following NAAG hydrolysis...
- alpha-latrotoxin action probed with recombinant toxin: receptors recruit alpha-latrotoxin but do not transduce an exocytotic signalK Ichtchenko
Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
EMBO J 17:6188-99. 1998..Exocytosis probably requires an additional receptor-independent activity of alpha-latrotoxin that is selectively inhibited by the LtxN4C mutation and by La3+...
- Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter releaseRichard W Cho
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Mol Cell Neurosci 45:389-97. 2010..Our findings indicate that the function of complexins as fusion clamps and facilitators of fusion are conserved across evolution, and that these roles are genetically separable within an isoform and across different isoforms...
- A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1Xiaolu Wang
Institut fur Physiologische Chemie, Ruhr Universitat Bochum, D 44780 Bochum, Germany
J Neurosci 29:12584-96. 2009....
- Fast excitatory synaptic transmission mediated by nicotinic acetylcholine receptors in Drosophila neuronsD Lee
Departments of Developmental and Cell Biology, Anatomy and Neurobiology, University of California Irvine, Irvine, California 92697 1280, USA
J Neurosci 19:5311-21. 1999....
- Metalearning and neuromodulationKenji Doya
ATR Human Information Science Laboratories, CREST, Japan Science and Technology Corporation, Kyoto
Neural Netw 15:495-506. 2002..The possible interactions between those neuromodulators and the environment are predicted on the basis of computational theory of metalearning...
- Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosisMarkus Missler
Center for Basic Neuroscience, Department of Molecular Genetics, Dallas, Texas 75390 9111, USA
Nature 423:939-48. 2003..These data suggest that alpha-neurexins organize presynaptic terminals by functionally coupling Ca2+ channels to the presynaptic machinery...
- Nicotinic receptor-based therapeutics and candidates for smoking cessationLinda P Dwoskin
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
Biochem Pharmacol 78:732-43. 2009..This review summarizes the currently available smoking cessation therapies and discusses emerging potential therapeutic approaches employing pharmacological agents which act as antagonists at nicotinic receptors...
- Neurotransmitter release at central synapsesCharles F Stevens
The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Neuron 40:381-8. 2003....
- Vesicular transmitter release from astrocytesVedrana Montana
Department of Cell Biology and Neuroscience, Center for Glial Neuronal Interactions, University of California, Riverside, California, USA
Glia 54:700-15. 2006..The location of specific exocytotic sites on these cells, however, remains to be unequivocally determined...
- Combining deconvolution and noise analysis for the estimation of transmitter release rates at the calyx of heldE Neher
Max-Planck-Institute for Biophysical Chemistry, Department of Membrane Biophysics, D-37077, , Germany
J Neurosci 21:444-61. 2001..Moreover, the method presented should provide a convenient way to study the kinetics of transmitter release at other synapses...
- Selegiline for Smoking CessationMARC POTENZA; Fiscal Year: 2007..Positive results from this trial would add further support for the safety and efficacy of selegiline for the treatment of nicotine dependence. ..
- fMRI of CBT and CM for Cocaine DependenceMARC POTENZA; Fiscal Year: 2009..Successful completion of this project would lay the foundation for future studies (e.g., those combining behavioral and pharmacological treatments) in cocaine dependence and other addictive disorders. ..
- fMRI of Craving in Addictions: Gender DifferencesMARC POTENZA; Fiscal Year: 2009..abstract_text> ..
- SYNUCLEIN FUNCTIONS: ROLE IN PARKINSON'S DISEASETHOMAS SUDHOF; Fiscal Year: 2003..We anticipate that these experiments will establish a molecular understanding of synuclein functions in the brain and provide insight into the role of an alpha synuclein in Parkinson's disease. ..
- APP, Alzheimer's Disease, and Synaptic FunctionTHOMAS SUDHOF; Fiscal Year: 2008..Together these studies will contribute to our understanding of APP function and Abeta toxicity in AD, and may suggest new avenues for interfering with the pathogenesis of AD. ..
- A systematic test of the relation of ASD heterogeneity to synaptic functionTHOMAS C contact SUDHOF; Fiscal Year: 2010..This project will address these issues by studying the changes in neuron-to-neuron communication caused by the genes associated with autism. ..
- Genetic Modulation of Left Ventricular RecoveryDennis McNamara; Fiscal Year: 2008..Specific Aim 3 will examine other genetic loci which act as modifiers of the cytokine and neurohomonal response, in particular NOS2, NOS3 and aldosterone synthase. ..
- MONOAMINERGIC CONTROL OF SPINAL INTERNEURONSCHARLES HECKMAN; Fiscal Year: 2004..These studies are likely to lead to novel pharmacological strategies to help restore normal function in spinal cord injury and stroke. ..
- Increased persistent sodium current in SOD1 motoneuronsCHARLES HECKMAN; Fiscal Year: 2009..These studies will play an essential role in determining if NaP makes an important contribution to motoneuron degeneration in ALS. Moreover, the results may prove invaluable in establishing new therapeutic strategies ..
- MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITYTheodore Slotkin; Fiscal Year: 2004..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
- Fetal & Adolescent Nicotine Effects on CNS 5HT SystemsTheodore Slotkin; Fiscal Year: 2003..abstract_text> ..
- Steroids and GABA: Physiology of Receptor Subunit ChangeSheryl S Smith; Fiscal Year: 2010..These results may be relevant for alterations in mood, cognition and seizure susceptibility (i.e., catamenial epilepsy) reported during puberty and across the menstrual cycle. ..
- DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEMTheodore Slotkin; Fiscal Year: 2003....
- Hormones Neuronal Phosphoproteins and BehaviorSHAILAJA MANI; Fiscal Year: 2008..These studies will provide information on the PKA/DARPP-32/PP-1 cascade regulation by progesterone and dopamine in mediating reproductive behavior. ..
- Dissection of Ethanol Actions on Cholinergic Nerve EndingsTIMOTHY SEARL; Fiscal Year: 2008..Our preliminary data with botulinums toxins demonstrate that the synaptic vesicle protein synaptobrevin is an important target for the effects of ethanol. [unreadable] [unreadable] [unreadable] [unreadable]..
- Electrochemical Analysis of Dopamine ReleaseMargaret Rice; Fiscal Year: 2007..Because unregulated H2O2 can lead to oxidative stress, however, the findings may also point to possible targets for therapeutic intervention in these disorders. ..
- Role of Histamine in Narcolepsy/EDS DisordersSeiji Nishino; Fiscal Year: 2008..As almost nothing is known on the pathophysiology of non- hypocretin deficient hypersomnias, we believe this work to be ideally suited for a small grant application. [unreadable] [unreadable] [unreadable]..
- The role of vesicle recycling in synaptic depressionEGE KAVALALI; Fiscal Year: 2008..This information will also be critical for a better understanding of the pathologies underlying several neurological and psychiatric illnesses ranging from epilepsy to schizophrenia. ..
- The Influence of Heart Failure Self-Care Behavior on Cardiac PerformanceChristopher Lee; Fiscal Year: 2008..This study will help determine if the day-to-day self-care behaviors of heart failure patients can influence how the heart functions. [unreadable] [unreadable] [unreadable]..
- Varenicline and Smoking Cessation in SchizophreniaSEYYED HOSSEIN FATEMI; Fiscal Year: 2010..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
- Prenatal Virally Induced Brain Disorder in MouseSEYYED FATEMI; Fiscal Year: 2009..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
- Lofexidine to Prevent Stress-Related Opiate RelapseRajita Sinha; Fiscal Year: 2007..abstract_text> ..
- COGNITIVE LOSS WITH AGE--ROLE OF CORTICAL CATECHOLAMINESAmy Arnsten; Fiscal Year: 2007..abstract_text> ..
- Immune /Glial Mediation of Exaggerated Pain StatesLinda Watkins; Fiscal Year: 2007..Additionally, the released time will foster further professional growth by yielding coherent blocks of time for concentrating on research and review projects. ..
- 2008 Synaptic Transmission Gordon Research ConferenceRalf Schneggenburger; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Mechanisms of Calcium Transients in Neuronal DevelopmentNicholas Spitzer; Fiscal Year: 2009..The long term goal is to provide information about the cellular and molecular machinery that governs processes of development, which will contribute to understanding developmental disorders of the nervous system. ..
- Neurochemical Organization of Brain Stem Respiratory NucleiMARGARET TT WONG RILEY; Fiscal Year: 2010....
- Pain facilitation via neuron-to-glia signalingLinda Watkins; Fiscal Year: 2009..Understanding this key step between neural activation &glial activation may have implications for developing new approaches for pain control. ..
- Role of hypocretin/histamine in Narcolepsy/EDS disordersSeiji Nishino; Fiscal Year: 2009..We believe that results from these studies will bring new insights regarding the roles of the hypocretin/histamine interaction in narcolepsy and other EDS disorders and better treatment modalities in humans. ..
- NEUROTRANSMITTER MODULATION OF NEURONAL CIRCUITSEve Marder; Fiscal Year: 2009..abstract_text> ..
- BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDESVivian Hook; Fiscal Year: 2009..These findings will enhance our knowledge of the complexity of the endogenous opioid system. ..
- Optoid Analgesics: Modulation of Trigeminal & Spinal Glial ActivationLinda Watkins; Fiscal Year: 2010..If successful, these studies will lead to development of novel adjunct therapies for improving clinical pain control by controlling the negative consequences of opioid-induced glial activation. ..
- Dynamic imaging of synaptic inhibition in the brainGeorge Augustine; Fiscal Year: 2009..abstract_text> ..
- INSECTICIDE ACTIONS ON GABA-A RECEPTORSGustav Akk; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Benzodiazepine Receptor in PTSDJAMES BREMNER; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Physiological Functions of Neuropeptide SRainer Reinscheid; Fiscal Year: 2009..We will study the pharmacology of the mutant receptor isoforms which may help to understand the physiological consequences of the mutation in human airway tissue. ..
- Spinal glia activation in human chronic painLinda Watkins; Fiscal Year: 2006..Either answer has major implications for the development of drug therapies for the control of clinical pain. [unreadable] [unreadable]..
- A new method to measure taste bud functionStephen Roper; Fiscal Year: 2004..If these cells turn out to be mechanoreceptors, the results may explain how taste buds detect food texture. This will greatly further our understanding of food selection and diet. ..
- Regulation of Dopamine Release by ROSMargaret Rice; Fiscal Year: 2004..Consistent with the goals of the R21 program, these data should provide ground-breaking new information about underlying mechanisms in nigrostriatal degeneration. ..
- Pain control via spinal interleukin-10 gene therapyLinda Watkins; Fiscal Year: 2003..This approach to pain control represents a dramatic departure from all other available therapies. ..
- PTP identity and inhibition for nigrostriatal protectionTheo Hagg; Fiscal Year: 2003..These studies will increase our understanding of how dopaminergic neurons function, validate our new treatment approach and provide us with research tools to improve it for application to Parkinson's disease. ..
- PAIN FACILITATION BY GP120 AND HIV ENVELOPE PROTEINLinda Watkins; Fiscal Year: 2003..In addition, it will be determined whether gp120 increases expression of activation markers in spinal glia, and whether disruption of glial function will block gp120-induced changes in pain response, end products and mRNA. ..
- POMC Processing and Beta-Endorphine-Related Opioid PeptidesVivian Y H Hook; Fiscal Year: 2010..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
- PHARMACOLOGICAL STUDIES OF HUMAN AND CANINE NARCOLEPSYSeiji Nishino; Fiscal Year: 2002....
- CYTOKINE-TO-BRAIN COMMUNICATION--ROLE OF THE VAGUSLinda Watkins; Fiscal Year: 2002..Additionally, the released time will foster further professional growth by yielding coherent blocks of time for concentrating on research and review projects. ..
- Dynamic Imaging of Synaptic InhibitionGeorge Augustine; Fiscal Year: 2002..abstract_text> ..
- METABOLIC ORGANIZATION & REGULATION IN THE VISUAL CORTEXMargaret Wong Riley; Fiscal Year: 2002..Results from these studies are expected to provide insight into the molecular basis of metabolic responses of visual cortical neurons to changing functional demands. ..
- 800 MHZ NMR SPECTROMETERJOSE RIZO REY; Fiscal Year: 2002..abstract_text> ..
- BIAcore 3000 SystemLESLIE GRIFFITH; Fiscal Year: 2002..The salary of the Principal Operator, as well as space in the Facility, and funds for maintenance of the instrument are guaranteed into the foreseeable future. ..
- ALLODYNIC EFFECTS OF SCIATIC INFLAMMATORY NEURITISLinda Watkins; Fiscal Year: 2004....
- Natural ligands for 2 endothelin-like orphan receptorsRainer Reinscheid; Fiscal Year: 2004..Identification of the natural ligands will enable us to study the physiological functions of these two orphan GPCRs under normal and pathological conditions. ..
- Transmission at Synapsin-deficient SynapsesGeorge Augustine; Fiscal Year: 2006..abstract_text> ..
- Serpin Protease Inhibitors & Opioid NeuropeptidesVivian Hook; Fiscal Year: 2006..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..
- Actions of Ethanol on Ligand-Gated Ion ChannelsGustav Akk; Fiscal Year: 2006..The results from the experiments will be used to examine the mechanism and structural requirements in the ethanol-mediated modulation of the GABAA receptor function. ..
- Steroid Hormones Regulatory Mechanisms and BehaviorSHAILAJA MANI; Fiscal Year: 2006..Identification of such cross-talk signaling mechanisms will contribute to our understanding of the environmental and internal determinants of hormone-brain-behavior mechanisms. ..
- Mechanisms of Long-Term Depression in the StriatumAnatol Kreitzer; Fiscal Year: 2005..These studies will provide a framework for understanding how long-term changes in synaptic strength in the striatum are related to such health issues as addiction and neurodegenerative disease. ..
- Estrogen, Stress and Dysfunction of Prefrontal CortexAmy Arnsten; Fiscal Year: 2005..This research will begin to reveal how estrogen amplifies the neurochemical cascades that lead to activation of CREB and dysfunction of the PFC during stress ..
- INTEGRATED DNA SEQUENCING SYSTEMVivian Hook; Fiscal Year: 2002..abstract_text> ..
- Mutants Showing SLO-1 Synaptic MislocalizationZhao Wen Wang; Fiscal Year: 2005..elegans. Analysis of these mutants in subsequent studies may allow the identification of molecules mediating SLO-1 synaptic targeting and localization. ..
- Methods Development for Studying Dorsal Spinal Cord GliaLinda Watkins; Fiscal Year: 2005..These new methods will then undergo initial assessments, in terms of functional characterization & receptor expression of the isolated astrocytes & microglia. ..
- Proteomics/Genomics of Opiate Analgesia and AddictionVivian Hook; Fiscal Year: 2004..Elucidation of distinct pathways will be significant, since it could allow future design of opiate drug regimens that provide effective analgesia, without the tolerance and dependence of addiction. ..
- MCH Modulation of Neurotransmission in the LH areaXiao Bing Gao; Fiscal Year: 2005..The funding of this research proposal is important for the applicant to continue this course. A career development plan is also documented in this proposal. ..
- The Michigan Clinical Research CollaboratoryDaniel Clauw; Fiscal Year: 2004..Disseminate findings, tools, and strategies from this project to other re-engineered networks and Research Centers, and ultimately interface with a National Electronics Clinical Trials and Research (NECTAR) network...
- The hypocretins and alcohol dependenceLuis de Lecea; Fiscal Year: 2003..The development of these mouse models will generate invaluable tools to assess the role of the hypocretins on drug abuse, and may help to design better treatments for sleep disorders associated with alcoholism. ..
- Mechanisms Underlying the Cognitive Function of SleepSubimal Datta; Fiscal Year: 2009....
- Trigeminal Mechanisms of Oral IrritationEarl Carstens; Fiscal Year: 2009..In a corresponding animal study, we will determine if responses of neurons in the n. tractus solitarius (NTS), a taste relay, are reduced by intraoral capsaicin ..
- NPY DEPRESSION OF HIPPOCAMPAL EPILEPSYAnthony van den Pol; Fiscal Year: 2002..NPY is potentially of great interest because its primary action in the normal hippocampus appears to be one of depressing hyperexcited neurons, without a substantial effect on normal neurotransmission. ..
- DJ-1 in Dopaminergic Neuronal Function and SurvivalJie Shen; Fiscal Year: 2009..Our long-term goal is to develop a genetic mouse model that recapitulates all central features of PD and to characterize the molecular pathways responsible for PD pathogenesis. ..
- GENETICS OF NEUROPEPTIDE Y FUNCTIONRICHARD PALMITER; Fiscal Year: 2001..These genetic experiments should help rationalize the current disparate results obtained by permanent NPY gene silencing and by acute intervention of NPY signaling. ..
- Planning Grant:Research on Blinding Eye Diseases (RMI)Darlene Dartt; Fiscal Year: 2006..Based on these findings, an application for an Interdisciplinary Center for Research on Blinding Eye Diseases will be prepared. [unreadable] [unreadable]..
- SYNAPTIC FUNCTION OF CNG CHANNELS IN THE RETINARichard Kramer; Fiscal Year: 2001..Preliminary results indicate that NO produces a sag in light response of horizontal cells in the intact retina. Whether this is due to effects on cones or effects on horizontal cells will be examined. ..