neurotransmitter agents

Summary

Summary: Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.

Top Publications

  1. pmc New insights into neuron-glia communication
    R Douglas Fields
    Neurocytology and Physiology Section, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Science 298:556-62. 2002
  2. ncbi The synaptic vesicle cycle
    Thomas C Sudhof
    Center for Basic Neuroscience, Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA Thomas
    Annu Rev Neurosci 27:509-47. 2004
  3. ncbi Hippocampal short- and long-term plasticity are not modulated by astrocyte Ca2+ signaling
    Cendra Agulhon
    Department of Pharmacology, University of North Carolina at Chapel Hill, Genetic Medicine Building, CB 7365, Chapel Hill, NC 27599, USA
    Science 327:1250-4. 2010
  4. ncbi Released fraction and total size of a pool of immediately available transmitter quanta at a calyx synapse
    R Schneggenburger
    Max Planck Institut fur biophysikalische Chemie, Abteilung Membranbiophysik, Gottingen, Germany
    Neuron 23:399-409. 1999
  5. ncbi Descending control of pain
    Mark J Millan
    Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy Seine, Paris, France
    Prog Neurobiol 66:355-474. 2002
  6. ncbi Essential functions of synapsins I and II in synaptic vesicle regulation
    T W Rosahl
    Department of Molecular Genetics, University of Texas Southwestern Medical School, Dallas 75235, USA
    Nature 375:488-93. 1995
  7. pmc CDK5 serves as a major control point in neurotransmitter release
    Sung Hyun Kim
    Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA
    Neuron 67:797-809. 2010
  8. ncbi Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?
    Alexander M Walter
    Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam and VU Medical Center, 1081 HV Amsterdam, The Netherlands
    Trends Neurosci 34:487-97. 2011
  9. ncbi Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters
    Atsuko Yamashita
    Department of Biochemistry and Molecular Biophysics and
    Nature 437:215-23. 2005
  10. pmc Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity
    N R Sibson
    Department of Molecular Biophysics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 95:316-21. 1998

Research Grants

  1. Selegiline for Smoking Cessation
    MARC POTENZA; Fiscal Year: 2007
  2. fMRI of CBT and CM for Cocaine Dependence
    MARC POTENZA; Fiscal Year: 2009
  3. fMRI of Craving in Addictions: Gender Differences
    MARC POTENZA; Fiscal Year: 2009
  4. SYNUCLEIN FUNCTIONS: ROLE IN PARKINSON'S DISEASE
    THOMAS SUDHOF; Fiscal Year: 2003
  5. APP, Alzheimer's Disease, and Synaptic Function
    THOMAS SUDHOF; Fiscal Year: 2008
  6. A systematic test of the relation of ASD heterogeneity to synaptic function
    THOMAS C contact SUDHOF; Fiscal Year: 2010
  7. Genetic Modulation of Left Ventricular Recovery
    Dennis McNamara; Fiscal Year: 2008
  8. MONOAMINERGIC CONTROL OF SPINAL INTERNEURONS
    CHARLES HECKMAN; Fiscal Year: 2004
  9. Increased persistent sodium current in SOD1 motoneurons
    CHARLES HECKMAN; Fiscal Year: 2009
  10. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004

Detail Information

Publications306 found, 100 shown here

  1. pmc New insights into neuron-glia communication
    R Douglas Fields
    Neurocytology and Physiology Section, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Science 298:556-62. 2002
    ..By releasing neurotransmitters and other extracellular signaling molecules, glia can affect neuronal excitability and synaptic transmission and perhaps coordinate activity across networks of neurons...
  2. ncbi The synaptic vesicle cycle
    Thomas C Sudhof
    Center for Basic Neuroscience, Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA Thomas
    Annu Rev Neurosci 27:509-47. 2004
    ..The present review attempts to relate these molecular data with physiological results in an emerging view of nerve terminals as macromolecular machines...
  3. ncbi Hippocampal short- and long-term plasticity are not modulated by astrocyte Ca2+ signaling
    Cendra Agulhon
    Department of Pharmacology, University of North Carolina at Chapel Hill, Genetic Medicine Building, CB 7365, Chapel Hill, NC 27599, USA
    Science 327:1250-4. 2010
    ..Our findings suggest that, at least in the hippocampus, the mechanisms of gliotransmission need to be reconsidered...
  4. ncbi Released fraction and total size of a pool of immediately available transmitter quanta at a calyx synapse
    R Schneggenburger
    Max Planck Institut fur biophysikalische Chemie, Abteilung Membranbiophysik, Gottingen, Germany
    Neuron 23:399-409. 1999
    ..The results reveal a surprisingly large pool of functionally available vesicles, of which a fraction of about 0.2 is released by a single presynaptic action potential under physiological conditions...
  5. ncbi Descending control of pain
    Mark J Millan
    Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy Seine, Paris, France
    Prog Neurobiol 66:355-474. 2002
    ..Knowledge of descending pathways has increased exponentially in recent years, so this is an opportune moment to survey their operation and therapeutic relevance to the improved management of pain...
  6. ncbi Essential functions of synapsins I and II in synaptic vesicle regulation
    T W Rosahl
    Department of Molecular Genetics, University of Texas Southwestern Medical School, Dallas 75235, USA
    Nature 375:488-93. 1995
    ....
  7. pmc CDK5 serves as a major control point in neurotransmitter release
    Sung Hyun Kim
    Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA
    Neuron 67:797-809. 2010
    ..These studies thus pinpoint CDK5 as a major control point for modulation of neurotransmitter release in mammalian neurons...
  8. ncbi Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?
    Alexander M Walter
    Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam and VU Medical Center, 1081 HV Amsterdam, The Netherlands
    Trends Neurosci 34:487-97. 2011
    ....
  9. ncbi Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters
    Atsuko Yamashita
    Department of Biochemistry and Molecular Biophysics and
    Nature 437:215-23. 2005
    ..The structure reveals the architecture of this important class of transporter, illuminates the determinants of substrate binding and ion selectivity, and defines the external and internal gates...
  10. pmc Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity
    N R Sibson
    Department of Molecular Biophysics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 95:316-21. 1998
    ..Another implication of this result is that brain activation studies, which map cortical oxidative Glc metabolism, provide a quantitative measure of synaptic glutamate release...
  11. ncbi RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone
    Susanne Schoch
    The Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    Nature 415:321-6. 2002
    ..These data indicate that RIM1alpha has a central function in integrating active zone proteins and synaptic vesicles into a molecular scaffold that controls neurotransmitter release...
  12. ncbi The calyx of Held
    Ralf Schneggenburger
    Laboratory of Synaptic Mechanisms, Ecole Polytechnique Federale de Lausanne EPFL, Brain Mind Institute, Bâtiment AAB, Station 15, CH 1015 Lausanne, Switzerland
    Cell Tissue Res 326:311-37. 2006
    ..Together, these studies convey the panopoly of presynaptic regulatory processes underlying the regulation of transmitter release, its modulatory control and short-term plasticity within one identified synaptic terminal...
  13. ncbi Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release
    Anton Maximov
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Neuron 48:547-54. 2005
    ..We propose that synaptotagmin 1 occupies release "slots" at the active zone, possibly in a Ca(2+)-independent complex with SNARE proteins that are freed when action potential-induced Ca(2+) influx activates synaptotagmin 1...
  14. ncbi Synaptotagmin I synchronizes transmitter release in mouse hippocampal neurons
    Tei ichi Nishiki
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 24:6127-32. 2004
    ..Thus, synaptotagmin I synchronizes the rapid release of neurotransmitters after Ca2+ entry into presynaptic terminals and also appears to suppress the slower, asynchronous form of transmitter release...
  15. pmc Beyond the wiring diagram: signalling through complex neuromodulator networks
    Vladimir Brezina
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
    Philos Trans R Soc Lond B Biol Sci 365:2363-74. 2010
    ....
  16. ncbi Hydrogen sulfide protects neurons against hypoxic injury via stimulation of ATP-sensitive potassium channel/protein kinase C/extracellular signal-regulated kinase/heat shock protein 90 pathway
    A S Tay
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 18 Medical Drive, Singapore
    Neuroscience 167:277-86. 2010
    ..Our findings emphasize the important neuroprotective role of H(2)S in the brain during cerebral hypoxia...
  17. pmc Neurobiology of gambling behaviors
    Marc N Potenza
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Curr Opin Neurobiol 23:660-7. 2013
    ..Considerations for future directions in gambling research, with a view towards translating neurobiological advances into more effective prevention and treatment strategies, are discussed. ..
  18. pmc Spillover-mediated feedforward inhibition functionally segregates interneuron activity
    Luke T Coddington
    Department of Neurobiology and Evelyn McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuron 78:1050-62. 2013
    ..These data demonstrate how glutamate release from single CFs modulates excitability of neighboring PCs, thus expanding the influence of CFs on cerebellar cortical activity in a manner not predicted by anatomical connectivity. ..
  19. pmc Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release
    Alexandra P Few
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 109:E452-60. 2012
    ....
  20. ncbi Reconstruction of aperture functions during full fusion in vesicular exocytosis of neurotransmitters
    Christian Amatore
    Departement de Chimie, Ecole Normale Superieure, UMR CNRS ENS UPMC 8640 PASTEUR, 24 rue Lhomond, 75231 Paris Cedex 05, France
    Chemphyschem 11:159-74. 2010
    ..Yet, a statistical analysis establishes that this maximum aperture angle is most probably less than a few tens of degrees, which suggests that full fusion is a very improbable event...
  21. pmc α2δ expression sets presynaptic calcium channel abundance and release probability
    Michael B Hoppa
    Department of Biochemistry, Weill Cornell Medical College, New York, New York 10023, USA
    Nature 486:122-5. 2012
    ..Our data reveal dual functionality of these clinically important VGCC subunits, allowing synapses to make more efficient use of Ca(2+) entry to drive neurotransmitter release...
  22. ncbi Tyramine as an independent transmitter and a precursor of octopamine in the locust central nervous system: an immunocytochemical study
    Natalia L Kononenko
    Freie Universitat Berlin, Institute of Biology, Neurobiology, D 14195 Berlin, Germany
    J Comp Neurol 512:433-52. 2009
    ..We conclude that tyramine is an independent transmitter in locusts, and that in octopaminergic neurons the ratio between octopamine and its precursor tyramine is highly dynamic...
  23. pmc High-throughput analysis of calcium signalling kinetics in astrocytes stimulated with different neurotransmitters
    Laura R James
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, United Kingdom
    PLoS ONE 6:e26889. 2011
    ..We conclude that the time course of global intracellular Ca(2+) signals does not offer the cells a means for distinguishing between different neurotransmitters...
  24. ncbi Astrocytic control of glutamatergic activity: astrocytes as stars of the show
    Leif Hertz
    College of Basic Medical Sciences, China Medical University, Shenyang, P R China
    Trends Neurosci 27:735-43. 2004
    ....
  25. pmc Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis
    Mingshan Xue
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 64:367-80. 2009
    ....
  26. pmc SV2 acts via presynaptic calcium to regulate neurotransmitter release
    Qun Fang Wan
    The Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Neuron 66:884-95. 2010
    ..Thus, SV2 controls key aspects of synaptic functionality via its ability to regulate presynaptic Ca(2+), suggesting a potential new target for therapeutic intervention in the treatment of epilepsy...
  27. ncbi Selective stimulation of astrocyte calcium in situ does not affect neuronal excitatory synaptic activity
    Todd A Fiacco
    Department of Pharmacology, 1004 Mary Ellen Jones Building CB 7365, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7365, USA
    Neuron 54:611-26. 2007
    ..Our findings call into question the developing consensus that Ca(2+)-dependent glutamate release by astrocytes directly affects neuronal synaptic activity in situ...
  28. ncbi Review on the influence of stress on immune mediators, neuropeptides and hormones with relevance for inflammatory bowel disease
    J H Niess
    Biomedizinisches Forschungszentrum, Campus Virchow Klinikum, Berlin, Germany
    Digestion 65:131-40. 2002
    ..e. neurotransmitters, hormones and immune cells, which are involved in the response to stress on the one hand, and contribute to the onset, progression or relapses of IBD on the other...
  29. ncbi Reduced anxiety-like behavior and central neurochemical change in germ-free mice
    K M Neufeld
    Brain Body Institute, St Joseph s Healthcare, Hamilton, ON, Canada
    Neurogastroenterol Motil 23:255-64, e119. 2011
    ..For example, the presence of gut microbiota regulates the set point for hypothalamic-pituitary-adrenal (HPA) axis activity...
  30. ncbi Uptake of botulinum neurotoxin into cultured neurons
    James E Keller
    Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 43:526-32. 2004
    ..This study demonstrates that uptake of both BoNT-A and -E is enhanced with synaptic activity and that translocation of the toxin catalytic moiety into the cytosol occurs at different rates for these two serotypes...
  31. ncbi Suicide neurobiology
    Carl Ernst
    McGill Group for Suicide Studies, McGill University, Montreal, Quebec, Canada
    Prog Neurobiol 89:315-33. 2009
    ....
  32. pmc Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release
    Jun Yao
    Howard Hughes Medical Institute and Department of Neuroscience, University of Wisconsin, Madison, WI 53706, USA
    Cell 147:666-77. 2011
    ..In summary, we propose that Doc2 is a Ca(2+) sensor that is kinetically tuned to regulate asynchronous neurotransmitter release...
  33. ncbi Neurotransmitter-mediated calcium signalling in oligodendrocyte physiology and pathology
    Arthur M Butt
    School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom
    Glia 54:666-75. 2006
    ..A key issue for future studies is to determine the physiological roles of neurotransmitters in mature oligodendrocytes and NG2-glia (synantocytes)...
  34. ncbi Distinct roles of different neural cell adhesion molecule (NCAM) isoforms in synaptic maturation revealed by analysis of NCAM 180 kDa isoform-deficient mice
    Luis Polo-Parada
    Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4975, USA
    J Neurosci 24:1852-64. 2004
    ..Together, these results indicate that different isoforms of NCAM mediate distinct and important events in presynaptic maturation...
  35. ncbi Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity
    J Hara
    Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Neuron 30:345-54. 2001
    ..Orexin/ataxin-3 mice provide a valuable model for studying the pathophysiology and treatment of narcolepsy...
  36. ncbi Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse
    M Geppert
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    Cell 79:717-27. 1994
    ..We propose that synaptotagmin I is the major low affinity Ca2+ sensor mediating Ca2+ regulation of synchronous neurotransmitter release in hippocampal neurons...
  37. ncbi Activity-dependent homeostatic specification of transmitter expression in embryonic neurons
    Laura N Borodinsky
    Neurobiology Section, Division of Biological Sciences and Center for Molecular Genetics, UCSD, La Jolla, California 92093 0357, USA
    Nature 429:523-30. 2004
    ..The results identify a new role of patterned activity in development of the central nervous system...
  38. pmc Review of recent advances in analytical techniques for the determination of neurotransmitters
    Maura Perry
    University of Michigan, Department of Chemistry, 930 N University, Ann Arbor, MI 48109 1055, USA
    Anal Chim Acta 653:1-22. 2009
    ..Advances in application to catecholamines, indoleamines, and amino acids have been prominent. Improvements in stability, sensitivity, and selectivity of the sensors have been of paramount interest...
  39. ncbi The antidepressant-sensitive dopamine transporter in Drosophila melanogaster: a primordial carrier for catecholamines
    P Porzgen
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Mol Pharmacol 59:83-95. 2001
    ..The identification of a cocaine-sensitive target linked to dopaminergic neurotransmission in D. melanogaster will serve as a basis for further dissection of the genetic components of psychostimulant-mediated behavior...
  40. ncbi Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugs
    Todd D Gould
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 30:1223-37. 2005
    ..In this regard, as is discussed, there is a major effort underway to develop novel, specific, GSK-3 inhibitors...
  41. ncbi ATP signaling is crucial for communication from taste buds to gustatory nerves
    Thomas E Finger
    Rocky Mountain Taste and Smell Center, Aurora CO 80045, USA
    Science 310:1495-9. 2005
    ..Finally, stimulation of taste buds in vitro evokes release of ATP. Thus, ATP fulfils the criteria for a neurotransmitter linking taste buds to the nervous system...
  42. ncbi Flame etching enhances the sensitivity of carbon-fiber microelectrodes
    Andrew M Strand
    Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904 4319, USA
    Anal Chem 80:3708-15. 2008
    ..The small flame-etched electrodes will facilitate measurements of low concentrations in discrete brain regions or small organisms...
  43. pmc Neurotransmitter receptors in the life and death of oligodendrocytes
    R Karadottir
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Neuroscience 145:1426-38. 2007
    ..Here we review the roles of neurotransmitter receptors in the normal function, and malfunction in pathological conditions, of oligodendrocytes...
  44. ncbi Selective capability of SynCAM and neuroligin for functional synapse assembly
    Yildirim Sara
    Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 25:260-70. 2005
    ..These results suggest that both NL1 and SynCAM act similarly and specifically in artificial synapse induction but that this process does not reflect a shared physiological function of these molecules...
  45. ncbi Cellular excitability and the regulation of functional neuronal identity: from gene expression to neuromodulation
    David J Schulz
    Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA
    J Neurosci 26:10362-7. 2006
  46. ncbi Effects of chronic restraint stress and estradiol on open field activity, spatial memory, and monoaminergic neurotransmitters in ovariectomized rats
    R E Bowman
    Department of Psychology, Hunter College of the City University of New York, 695 Park Avenue, New York, NY 10021, USA
    Neuroscience 113:401-10. 2002
    ..Results show that estradiol may moderate stress effects on cognition and anxiety through both organizational and activation effects...
  47. ncbi Functional and chemical anatomy of the afferent vagal system
    H R Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Auton Neurosci 85:1-17. 2000
    ..Furthermore, these functions are in line with a general defensive character ascribed to the vagal afferent, paraventricular system in lower vertebrates...
  48. ncbi Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system
    John A Dani
    Department of Neuroscience, Program of Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Annu Rev Pharmacol Toxicol 47:699-729. 2007
    ..Decline, disruption, or alterations of nicotinic cholinergic mechanisms contribute to dysfunctions such as epilepsy, schizophrenia, Parkinson's disease, autism, dementia with Lewy bodies, Alzheimer's disease, and addiction...
  49. pmc Functional groups modulate the sensitivity and electron transfer kinetics of neurochemicals at carbon nanotube modified microelectrodes
    Christopher B Jacobs
    Dept of Chemistry, University of Virginia, P O Box 400319, Charlottesville, VA 22904, USA
    Analyst 136:3557-65. 2011
    ..The functional groups of CNTs therefore modulate the electrochemical properties, and the increase in sensitivity from CNT modification facilitates measurements in biological samples...
  50. ncbi Substantial changes in central nervous system neurotransmitters and neuromodulators accompany phase change in the locust
    Stephen M Rogers
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    J Exp Biol 207:3603-17. 2004
    ..Our data show that changes in levels of neuroactive substances are widespread in the central nervous system and reflect the time course of behavioural and physiological phase change...
  51. pmc Synapsin II and calcium regulate vesicle docking and the cross-talk between vesicle pools at the mouse motor terminals
    William L Coleman
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    J Physiol 586:4649-73. 2008
    ..The results of the modelling were in a good agreement with the observed dependence of vesicle distribution on synapsin II and calcium deficiency...
  52. ncbi Neurotransmitter receptors on microglia
    Jennifer M Pocock
    Cell Signalling Laboratory, Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
    Trends Neurosci 30:527-35. 2007
    ..Understanding how microglia respond to different neurotransmitters will thus have important implications for controlling the reactivity of these cells in acute injury, as well as for treating chronic neurodegenerative diseases...
  53. ncbi Impact of gestational and lactational phthalate exposure on hypothalamic content of amino acid neurotransmitters and FSH secretion in peripubertal male rats
    Silvia Carbone
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires, Argentina
    Neurotoxicology 31:747-51. 2010
    ..This could be related with the gonadotropin modifications also here described...
  54. ncbi Synaptic assembly of the brain in the absence of neurotransmitter secretion
    M Verhage
    Molecular Neuroscience, Rudolf Magnus Institute, University of Utrecht Medical Centre, Utrecht, Netherlands
    Science 287:864-9. 2000
    ..Thus, synaptic connectivity does not depend on neurotransmitter secretion, but its maintenance does. Neurotransmitter secretion probably functions to validate already established synaptic connections...
  55. pmc SV2 regulates neurotransmitter release via multiple mechanisms
    Amy Nowack
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    Am J Physiol Cell Physiol 299:C960-7. 2010
    ..These results indicate that SV2 performs at least two actions at the synapse that contribute to neurotransmitter release...
  56. ncbi Serotonin involvement in the metamorphosis of the hydroid Eudendrium racemosum
    Giuliana Zega
    Dipartimento di Biologia, Sez Zoologia S N, Universit Statale di Milano, Milan, Italy
    Int J Dev Biol 51:307-13. 2007
    ..Results from this work showed that 5-HT could stimulate metamorphosis in E. racemosum planulae in the presence of a natural inducer. A mechanism by which this neurotransmitter could act in this phase is proposed...
  57. pmc Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter
    Ali El-Kasaby
    Institute of Pharmacology, Center of Physiology and Pharmacology, Medical University of Vienna, Währinger Str 13a, A 1090 Vienna, Austria
    J Biol Chem 285:39201-10. 2010
    ....
  58. ncbi How does synaptotagmin trigger neurotransmitter release?
    Edwin R Chapman
    Howard Hughes Medical Institute and Department of Physiology, University of Wisconsin, Madison, WI 53706, USA
    Annu Rev Biochem 77:615-41. 2008
    ..This work sheds light not only on presynaptic aspects of synaptic transmission, but also on the fundamental problem of membrane fusion, which has remained a puzzle that has yet to be solved in any biological system...
  59. pmc Identification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neurons
    Yu Jin Won
    1Section on Transmitter Signaling, Laboratory of Molecular Physiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9411, USA
    J Neurophysiol 105:442-53. 2011
    ..These results provide the basis for using the zebrafish model system to understanding Ca(2+) channel function, and in turn, how Ca(2+) channels contribute to mechanosensory function...
  60. ncbi A small number of open Ca2+ channels trigger transmitter release at a central GABAergic synapse
    Iancu Bucurenciu
    Institute of Physiology I, Universitat Freiburg, Freiburg, Germany
    Nat Neurosci 13:19-21. 2010
    ..Furthermore, a small number of Ca(2+) channels were able to evoke release with high temporal precision, despite stochastic Ca(2+) channel opening...
  61. ncbi Deleterious effects in mice of fish-associated methylmercury contained in a diet mimicking the Western populations' average fish consumption
    Jean Paul Bourdineaud
    Bordeaux University CNRS, UMR EPOC 5805, Arcachon Marine Station, Place du Docteur Peyneau, Arcachon, 33120, France
    Environ Int 37:303-13. 2011
    ....
  62. pmc Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis
    Kazuhiro Tokuda
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:16788-95. 2010
    ..Thus, dual activation of CBRs and TSPO appears to result in unique actions of clinically important BDZs. Furthermore, endogenous neurosteroids are shown to be important regulators of pyramidal neuron function and synaptic plasticity...
  63. pmc P2Y nucleotide receptors: promise of therapeutic applications
    Kenneth A Jacobson
    Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Drug Discov Today 15:570-8. 2010
    ..On the horizon are novel treatments for cardiovascular diseases, inflammatory diseases and neurodegeneration...
  64. pmc Bidirectional regulation of thermotaxis by glutamate transmissions in Caenorhabditis elegans
    Noriyuki Ohnishi
    Laboratory of Molecular Neurobiology, Division of Biological Science, Department of Molecular Biology, Graduate School of Science, Nagoya University, Nagoya, Aichi, Japan
    EMBO J 30:1376-88. 2011
    ..We thus provide an important insight on information processing, in which two glutamate transmissions encoding opposite information flows regulate neural activities to produce a large spectrum of behavioural outputs...
  65. ncbi Contralateral high or a combination of high- and low-frequency transcutaneous electrical nerve stimulation reduces mechanical allodynia and alters dorsal horn neurotransmitter content in neuropathic rats
    David L Somers
    Department of Physical Therapy, John G Rangos Sr School of Health Sciences, Duquesne University, Pittsburgh, Pennsylvania, USA
    J Pain 10:221-9. 2009
    ..The present findings support a contralateral approach to the application of TENS and suggest that distinct strategies for TENS application may differentially alter neurotransmission in the central nervous system...
  66. pmc cJun integrates calcium activity and tlx3 expression to regulate neurotransmitter specification
    Kurt W Marek
    Neurobiology Section, Division of Biological Sciences and Center for Neural Circuits, Kavli Institute for Brain and Mind, University of California San Diego, La Jolla, California, USA
    Nat Neurosci 13:944-50. 2010
    ..This mechanism provides a basis for early activity to regulate genetic pathways at critical decision points, switching the phenotype of developing neurons...
  67. pmc GABA, its receptors, and GABAergic inhibition in mouse taste buds
    Gennady Dvoryanchikov
    Department of Physiology and Biophysics and Program in Neuroscience, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Neurosci 31:5782-91. 2011
    ..We conclude that GABA is an inhibitory transmitter released during taste stimulation and possibly also during growth and differentiation of taste buds...
  68. ncbi The molecular biology of memory storage: a dialogue between genes and synapses
    E R Kandel
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Science 294:1030-8. 2001
    ....
  69. pmc The timing of phasic transmitter release is Ca2+-dependent and lacks a direct influence of presynaptic membrane potential
    Felix Felmy
    AG Synaptische Dynamik und Modulation and Abteilung Membranbiophysik, Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, D 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 100:15200-5. 2003
    ....
  70. pmc Monoamine neurotransmitters as substrates for novel tick sulfotransferases, homology modeling, molecular docking, and enzyme kinetics
    Emine Bihter Yalcin
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, United States
    ACS Chem Biol 6:176-84. 2011
    ....
  71. pmc Neurotransmitter receptors as central regulators of pancreatic cancer
    Hildegard M Schuller
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Future Oncol 6:221-8. 2010
    ..Accordingly, PDAC intervention strategies should include the diagnosis of unphysiological neurotransmitter levels and aim to restore any imbalance in stimulatory and inhibitory neurotransmitters...
  72. ncbi Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release
    J T Littleton
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
    Cell 74:1125-34. 1993
    ..These results provide in vivo evidence that syt plays a key role in Ca2+ activation of neurotransmitter release and indicate the existence of separate pathways for evoked and spontaneous neurotransmitter release...
  73. ncbi Multiple roles of calcium ions in the regulation of neurotransmitter release
    Erwin Neher
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Neuron 59:861-72. 2008
    ..Such coupling is essential for rendering vesicles sensitive to short [Ca(2+)] transients, generated during action potentials...
  74. pmc The binomial model in fluctuation analysis of quantal neurotransmitter release
    D M Quastel
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Biophys J 72:728-53. 1997
    ....
  75. ncbi The probability of neurotransmitter release: variability and feedback control at single synapses
    Tiago Branco
    Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, WC1E 6BT, UK
    Nat Rev Neurosci 10:373-83. 2009
    ..This local tuning of transmission has important implications for current models of single-neuron computation...
  76. ncbi Neurotransmitter properties of spinal interneurons in embryonic and larval zebrafish
    Shin Ichi Higashijima
    Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, New York 11794 5230, USA
    J Comp Neurol 480:19-37. 2004
    ..Our approach allowed us to define the likely transmitter phenotypes of most of the known classes of spinal interneurons. These data provide a foundation for understanding the functional organization of the spinal networks in zebrafish...
  77. ncbi The low synaptic release probability in vivo
    J Gerard G Borst
    Department of Neuroscience, Erasmus MC, University Medical Center Rotterdam, 3015 GE Rotterdam, The Netherlands
    Trends Neurosci 33:259-66. 2010
    ..Existing evidence thus suggests that under physiological conditions in vivo, presynaptic action potentials trigger the release of neurotransmitter much less frequently than what is observed in in vitro preparations...
  78. ncbi Cellular, synaptic and network effects of neuromodulation
    Eve Marder
    Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454 9110, USA
    Neural Netw 15:479-93. 2002
    ..Some of the computational consequences of these features of modulator action are discussed...
  79. ncbi PACAP potentiates L-type calcium channel conductance in suprachiasmatic nucleus neurons by activating the MAPK pathway
    Heather Dziema
    Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurophysiol 88:1374-86. 2002
    ..The data presented here identify potentially important mechanisms by which PACAP regulates SCN physiology...
  80. ncbi RIM1alpha is required for presynaptic long-term potentiation
    Pablo E Castillo
    Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94304, USA
    Nature 415:327-30. 2002
    ....
  81. ncbi Light-induced phase shift in the Syrian hamster (Mesocricetus auratus) is attenuated by the PACAP receptor antagonist PACAP6-38 or PACAP immunoneutralization
    A L Bergström
    Department of Clinical Biochemistry, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
    Eur J Neurosci 18:2552-62. 2003
    ..The findings indicate that PACAP is a neurotransmitter of the RHT mediating photic information to the clock, possibly via melanopsin located exclusively on the PACAP-expressing cells of the RHT...
  82. ncbi Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems
    S A Deuchars
    School of Biomedical Sciences, University of Leeds, LS2 9NQ, Leeds, United Kingdom
    J Neurosci 21:7143-52. 2001
    ..Such a widespread distribution and functional role suggests that the receptor may be involved in the fundamental regulation of synaptic transmission at the presynaptic site...
  83. ncbi Malignant gliomas: perverting glutamate and ion homeostasis for selective advantage
    Harald Sontheimer
    Department of Neurobiology and Civitan International Research Center, The University of Alabama at Birmingham, Birmingham, AL 35244, USA
    Trends Neurosci 26:543-9. 2003
    ..Recent research suggests that astrocyte-derived tumors co-opt neurotransmitters, their transporters and ion channels to support their unusual growth and invasive migration...
  84. pmc Asynchronous transmitter release from cholecystokinin-containing inhibitory interneurons is widespread and target-cell independent
    Michael I Daw
    Program in Developmental Neuroscience, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 29:11112-22. 2009
    ....
  85. ncbi Neurotransmitters and prefrontal cortex-limbic system interactions: implications for plasticity and psychiatric disorders
    Alberto Del Arco
    Department of Physiology, Faculty of Medicine, Universidad Complutense, Madrid, Spain
    J Neural Transm 116:941-52. 2009
    ..Finally, it is speculated that changes in the function of the PFC, associated with psychiatric disorders or due to environmental-dependent plasticity, can change PFC-limbic system interactions...
  86. ncbi The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion
    M Geppert
    Max Planck Institute for Experimental Medicine, Gottingen, Germany
    Nature 387:810-4. 1997
    ....
  87. ncbi Neuromodulation intrinsic to the central pattern generator for escape swimming in Tritonia
    P S Katz
    Department of Biology, Georgia State University, Atlanta 30302, USA
    Ann N Y Acad Sci 860:181-8. 1998
    ..These neuromodulatory actions intrinsic to the CPG may be important for the initial self-configuration of the system into a function CPG and for experience-dependent changes in the output such as behavioral sensitization and habituation...
  88. ncbi A review of neurohormone GPCRs present in the fruitfly Drosophila melanogaster and the honey bee Apis mellifera
    Frank Hauser
    Center for Functional and Comparative Insect Genomics, Department of Cell Biology and Comparative Zoology, Institute of Biology, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Prog Neurobiol 80:1-19. 2006
    ..This is in contrast to biogenic amine GPCRs, where evolutionarily unrelated GPCRs often bind to the same biogenic amine, suggesting frequent ligand exchanges ("ligand hops") during GPCR evolution...
  89. pmc Monitoring rapid chemical communication in the brain
    Donita L Robinson
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3290, USA
    Chem Rev 108:2554-84. 2008
  90. pmc Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release
    Alexander J Groffen
    Department of Functional Genomics, CNCR, Neuroscience Campus Amsterdam, VU University and VU Medical Center, Amsterdam, 1081 HV, Netherlands
    Science 327:1614-8. 2010
    ....
  91. ncbi N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system
    J H Neale
    Department of Biology, Georgetown University, Washington, D C, USA
    J Neurochem 75:443-52. 2000
    ..A second role is the production of extracellular glutamate following NAAG hydrolysis...
  92. pmc alpha-latrotoxin action probed with recombinant toxin: receptors recruit alpha-latrotoxin but do not transduce an exocytotic signal
    K Ichtchenko
    Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    EMBO J 17:6188-99. 1998
    ..Exocytosis probably requires an additional receptor-independent activity of alpha-latrotoxin that is selectively inhibited by the LtxN4C mutation and by La3+...
  93. pmc Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release
    Richard W Cho
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cell Neurosci 45:389-97. 2010
    ..Our findings indicate that the function of complexins as fusion clamps and facilitators of fusion are conserved across evolution, and that these roles are genetically separable within an isoform and across different isoforms...
  94. ncbi A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1
    Xiaolu Wang
    Institut fur Physiologische Chemie, Ruhr Universitat Bochum, D 44780 Bochum, Germany
    J Neurosci 29:12584-96. 2009
    ....
  95. ncbi Fast excitatory synaptic transmission mediated by nicotinic acetylcholine receptors in Drosophila neurons
    D Lee
    Departments of Developmental and Cell Biology, Anatomy and Neurobiology, University of California Irvine, Irvine, California 92697 1280, USA
    J Neurosci 19:5311-21. 1999
    ....
  96. ncbi Metalearning and neuromodulation
    Kenji Doya
    ATR Human Information Science Laboratories, CREST, Japan Science and Technology Corporation, Kyoto
    Neural Netw 15:495-506. 2002
    ..The possible interactions between those neuromodulators and the environment are predicted on the basis of computational theory of metalearning...
  97. ncbi Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis
    Markus Missler
    Center for Basic Neuroscience, Department of Molecular Genetics, Dallas, Texas 75390 9111, USA
    Nature 423:939-48. 2003
    ..These data suggest that alpha-neurexins organize presynaptic terminals by functionally coupling Ca2+ channels to the presynaptic machinery...
  98. pmc Nicotinic receptor-based therapeutics and candidates for smoking cessation
    Linda P Dwoskin
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Biochem Pharmacol 78:732-43. 2009
    ..This review summarizes the currently available smoking cessation therapies and discusses emerging potential therapeutic approaches employing pharmacological agents which act as antagonists at nicotinic receptors...
  99. ncbi Neurotransmitter release at central synapses
    Charles F Stevens
    The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 40:381-8. 2003
    ....
  100. ncbi Vesicular transmitter release from astrocytes
    Vedrana Montana
    Department of Cell Biology and Neuroscience, Center for Glial Neuronal Interactions, University of California, Riverside, California, USA
    Glia 54:700-15. 2006
    ..The location of specific exocytotic sites on these cells, however, remains to be unequivocally determined...
  101. ncbi Combining deconvolution and noise analysis for the estimation of transmitter release rates at the calyx of held
    E Neher
    Max-Planck-Institute for Biophysical Chemistry, Department of Membrane Biophysics, D-37077, , Germany
    J Neurosci 21:444-61. 2001
    ..Moreover, the method presented should provide a convenient way to study the kinetics of transmitter release at other synapses...

Research Grants73

  1. Selegiline for Smoking Cessation
    MARC POTENZA; Fiscal Year: 2007
    ..Positive results from this trial would add further support for the safety and efficacy of selegiline for the treatment of nicotine dependence. ..
  2. fMRI of CBT and CM for Cocaine Dependence
    MARC POTENZA; Fiscal Year: 2009
    ..Successful completion of this project would lay the foundation for future studies (e.g., those combining behavioral and pharmacological treatments) in cocaine dependence and other addictive disorders. ..
  3. fMRI of Craving in Addictions: Gender Differences
    MARC POTENZA; Fiscal Year: 2009
    ..abstract_text> ..
  4. SYNUCLEIN FUNCTIONS: ROLE IN PARKINSON'S DISEASE
    THOMAS SUDHOF; Fiscal Year: 2003
    ..We anticipate that these experiments will establish a molecular understanding of synuclein functions in the brain and provide insight into the role of an alpha synuclein in Parkinson's disease. ..
  5. APP, Alzheimer's Disease, and Synaptic Function
    THOMAS SUDHOF; Fiscal Year: 2008
    ..Together these studies will contribute to our understanding of APP function and Abeta toxicity in AD, and may suggest new avenues for interfering with the pathogenesis of AD. ..
  6. A systematic test of the relation of ASD heterogeneity to synaptic function
    THOMAS C contact SUDHOF; Fiscal Year: 2010
    ..This project will address these issues by studying the changes in neuron-to-neuron communication caused by the genes associated with autism. ..
  7. Genetic Modulation of Left Ventricular Recovery
    Dennis McNamara; Fiscal Year: 2008
    ..Specific Aim 3 will examine other genetic loci which act as modifiers of the cytokine and neurohomonal response, in particular NOS2, NOS3 and aldosterone synthase. ..
  8. MONOAMINERGIC CONTROL OF SPINAL INTERNEURONS
    CHARLES HECKMAN; Fiscal Year: 2004
    ..These studies are likely to lead to novel pharmacological strategies to help restore normal function in spinal cord injury and stroke. ..
  9. Increased persistent sodium current in SOD1 motoneurons
    CHARLES HECKMAN; Fiscal Year: 2009
    ..These studies will play an essential role in determining if NaP makes an important contribution to motoneuron degeneration in ALS. Moreover, the results may prove invaluable in establishing new therapeutic strategies ..
  10. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  11. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  12. Steroids and GABA: Physiology of Receptor Subunit Change
    Sheryl S Smith; Fiscal Year: 2010
    ..These results may be relevant for alterations in mood, cognition and seizure susceptibility (i.e., catamenial epilepsy) reported during puberty and across the menstrual cycle. ..
  13. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  14. Hormones Neuronal Phosphoproteins and Behavior
    SHAILAJA MANI; Fiscal Year: 2008
    ..These studies will provide information on the PKA/DARPP-32/PP-1 cascade regulation by progesterone and dopamine in mediating reproductive behavior. ..
  15. Dissection of Ethanol Actions on Cholinergic Nerve Endings
    TIMOTHY SEARL; Fiscal Year: 2008
    ..Our preliminary data with botulinums toxins demonstrate that the synaptic vesicle protein synaptobrevin is an important target for the effects of ethanol. [unreadable] [unreadable] [unreadable] [unreadable]..
  16. Electrochemical Analysis of Dopamine Release
    Margaret Rice; Fiscal Year: 2007
    ..Because unregulated H2O2 can lead to oxidative stress, however, the findings may also point to possible targets for therapeutic intervention in these disorders. ..
  17. Role of Histamine in Narcolepsy/EDS Disorders
    Seiji Nishino; Fiscal Year: 2008
    ..As almost nothing is known on the pathophysiology of non- hypocretin deficient hypersomnias, we believe this work to be ideally suited for a small grant application. [unreadable] [unreadable] [unreadable]..
  18. The role of vesicle recycling in synaptic depression
    EGE KAVALALI; Fiscal Year: 2008
    ..This information will also be critical for a better understanding of the pathologies underlying several neurological and psychiatric illnesses ranging from epilepsy to schizophrenia. ..
  19. The Influence of Heart Failure Self-Care Behavior on Cardiac Performance
    Christopher Lee; Fiscal Year: 2008
    ..This study will help determine if the day-to-day self-care behaviors of heart failure patients can influence how the heart functions. [unreadable] [unreadable] [unreadable]..
  20. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  21. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  22. Lofexidine to Prevent Stress-Related Opiate Relapse
    Rajita Sinha; Fiscal Year: 2007
    ..abstract_text> ..
  23. COGNITIVE LOSS WITH AGE--ROLE OF CORTICAL CATECHOLAMINES
    Amy Arnsten; Fiscal Year: 2007
    ..abstract_text> ..
  24. Immune /Glial Mediation of Exaggerated Pain States
    Linda Watkins; Fiscal Year: 2007
    ..Additionally, the released time will foster further professional growth by yielding coherent blocks of time for concentrating on research and review projects. ..
  25. 2008 Synaptic Transmission Gordon Research Conference
    Ralf Schneggenburger; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  26. Mechanisms of Calcium Transients in Neuronal Development
    Nicholas Spitzer; Fiscal Year: 2009
    ..The long term goal is to provide information about the cellular and molecular machinery that governs processes of development, which will contribute to understanding developmental disorders of the nervous system. ..
  27. Neurochemical Organization of Brain Stem Respiratory Nuclei
    MARGARET TT WONG RILEY; Fiscal Year: 2010
    ....
  28. Pain facilitation via neuron-to-glia signaling
    Linda Watkins; Fiscal Year: 2009
    ..Understanding this key step between neural activation &glial activation may have implications for developing new approaches for pain control. ..
  29. Role of hypocretin/histamine in Narcolepsy/EDS disorders
    Seiji Nishino; Fiscal Year: 2009
    ..We believe that results from these studies will bring new insights regarding the roles of the hypocretin/histamine interaction in narcolepsy and other EDS disorders and better treatment modalities in humans. ..
  30. NEUROTRANSMITTER MODULATION OF NEURONAL CIRCUITS
    Eve Marder; Fiscal Year: 2009
    ..abstract_text> ..
  31. BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDES
    Vivian Hook; Fiscal Year: 2009
    ..These findings will enhance our knowledge of the complexity of the endogenous opioid system. ..
  32. Optoid Analgesics: Modulation of Trigeminal & Spinal Glial Activation
    Linda Watkins; Fiscal Year: 2010
    ..If successful, these studies will lead to development of novel adjunct therapies for improving clinical pain control by controlling the negative consequences of opioid-induced glial activation. ..
  33. Dynamic imaging of synaptic inhibition in the brain
    George Augustine; Fiscal Year: 2009
    ..abstract_text> ..
  34. INSECTICIDE ACTIONS ON GABA-A RECEPTORS
    Gustav Akk; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  35. Benzodiazepine Receptor in PTSD
    JAMES BREMNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  36. Physiological Functions of Neuropeptide S
    Rainer Reinscheid; Fiscal Year: 2009
    ..We will study the pharmacology of the mutant receptor isoforms which may help to understand the physiological consequences of the mutation in human airway tissue. ..
  37. Spinal glia activation in human chronic pain
    Linda Watkins; Fiscal Year: 2006
    ..Either answer has major implications for the development of drug therapies for the control of clinical pain. [unreadable] [unreadable]..
  38. A new method to measure taste bud function
    Stephen Roper; Fiscal Year: 2004
    ..If these cells turn out to be mechanoreceptors, the results may explain how taste buds detect food texture. This will greatly further our understanding of food selection and diet. ..
  39. Regulation of Dopamine Release by ROS
    Margaret Rice; Fiscal Year: 2004
    ..Consistent with the goals of the R21 program, these data should provide ground-breaking new information about underlying mechanisms in nigrostriatal degeneration. ..
  40. Pain control via spinal interleukin-10 gene therapy
    Linda Watkins; Fiscal Year: 2003
    ..This approach to pain control represents a dramatic departure from all other available therapies. ..
  41. PTP identity and inhibition for nigrostriatal protection
    Theo Hagg; Fiscal Year: 2003
    ..These studies will increase our understanding of how dopaminergic neurons function, validate our new treatment approach and provide us with research tools to improve it for application to Parkinson's disease. ..
  42. PAIN FACILITATION BY GP120 AND HIV ENVELOPE PROTEIN
    Linda Watkins; Fiscal Year: 2003
    ..In addition, it will be determined whether gp120 increases expression of activation markers in spinal glia, and whether disruption of glial function will block gp120-induced changes in pain response, end products and mRNA. ..
  43. POMC Processing and Beta-Endorphine-Related Opioid Peptides
    Vivian Y H Hook; Fiscal Year: 2010
    ..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
  44. PHARMACOLOGICAL STUDIES OF HUMAN AND CANINE NARCOLEPSY
    Seiji Nishino; Fiscal Year: 2002
    ....
  45. CYTOKINE-TO-BRAIN COMMUNICATION--ROLE OF THE VAGUS
    Linda Watkins; Fiscal Year: 2002
    ..Additionally, the released time will foster further professional growth by yielding coherent blocks of time for concentrating on research and review projects. ..
  46. Dynamic Imaging of Synaptic Inhibition
    George Augustine; Fiscal Year: 2002
    ..abstract_text> ..
  47. METABOLIC ORGANIZATION & REGULATION IN THE VISUAL CORTEX
    Margaret Wong Riley; Fiscal Year: 2002
    ..Results from these studies are expected to provide insight into the molecular basis of metabolic responses of visual cortical neurons to changing functional demands. ..
  48. 800 MHZ NMR SPECTROMETER
    JOSE RIZO REY; Fiscal Year: 2002
    ..abstract_text> ..
  49. BIAcore 3000 System
    LESLIE GRIFFITH; Fiscal Year: 2002
    ..The salary of the Principal Operator, as well as space in the Facility, and funds for maintenance of the instrument are guaranteed into the foreseeable future. ..
  50. ALLODYNIC EFFECTS OF SCIATIC INFLAMMATORY NEURITIS
    Linda Watkins; Fiscal Year: 2004
    ....
  51. Natural ligands for 2 endothelin-like orphan receptors
    Rainer Reinscheid; Fiscal Year: 2004
    ..Identification of the natural ligands will enable us to study the physiological functions of these two orphan GPCRs under normal and pathological conditions. ..
  52. Transmission at Synapsin-deficient Synapses
    George Augustine; Fiscal Year: 2006
    ..abstract_text> ..
  53. Serpin Protease Inhibitors & Opioid Neuropeptides
    Vivian Hook; Fiscal Year: 2006
    ..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..
  54. Actions of Ethanol on Ligand-Gated Ion Channels
    Gustav Akk; Fiscal Year: 2006
    ..The results from the experiments will be used to examine the mechanism and structural requirements in the ethanol-mediated modulation of the GABAA receptor function. ..
  55. Steroid Hormones Regulatory Mechanisms and Behavior
    SHAILAJA MANI; Fiscal Year: 2006
    ..Identification of such cross-talk signaling mechanisms will contribute to our understanding of the environmental and internal determinants of hormone-brain-behavior mechanisms. ..
  56. Mechanisms of Long-Term Depression in the Striatum
    Anatol Kreitzer; Fiscal Year: 2005
    ..These studies will provide a framework for understanding how long-term changes in synaptic strength in the striatum are related to such health issues as addiction and neurodegenerative disease. ..
  57. Estrogen, Stress and Dysfunction of Prefrontal Cortex
    Amy Arnsten; Fiscal Year: 2005
    ..This research will begin to reveal how estrogen amplifies the neurochemical cascades that lead to activation of CREB and dysfunction of the PFC during stress ..
  58. INTEGRATED DNA SEQUENCING SYSTEM
    Vivian Hook; Fiscal Year: 2002
    ..abstract_text> ..
  59. Mutants Showing SLO-1 Synaptic Mislocalization
    Zhao Wen Wang; Fiscal Year: 2005
    ..elegans. Analysis of these mutants in subsequent studies may allow the identification of molecules mediating SLO-1 synaptic targeting and localization. ..
  60. Methods Development for Studying Dorsal Spinal Cord Glia
    Linda Watkins; Fiscal Year: 2005
    ..These new methods will then undergo initial assessments, in terms of functional characterization & receptor expression of the isolated astrocytes & microglia. ..
  61. Proteomics/Genomics of Opiate Analgesia and Addiction
    Vivian Hook; Fiscal Year: 2004
    ..Elucidation of distinct pathways will be significant, since it could allow future design of opiate drug regimens that provide effective analgesia, without the tolerance and dependence of addiction. ..
  62. MCH Modulation of Neurotransmission in the LH area
    Xiao Bing Gao; Fiscal Year: 2005
    ..The funding of this research proposal is important for the applicant to continue this course. A career development plan is also documented in this proposal. ..
  63. The Michigan Clinical Research Collaboratory
    Daniel Clauw; Fiscal Year: 2004
    ..Disseminate findings, tools, and strategies from this project to other re-engineered networks and Research Centers, and ultimately interface with a National Electronics Clinical Trials and Research (NECTAR) network...
  64. The hypocretins and alcohol dependence
    Luis de Lecea; Fiscal Year: 2003
    ..The development of these mouse models will generate invaluable tools to assess the role of the hypocretins on drug abuse, and may help to design better treatments for sleep disorders associated with alcoholism. ..
  65. Mechanisms Underlying the Cognitive Function of Sleep
    Subimal Datta; Fiscal Year: 2009
    ....
  66. Trigeminal Mechanisms of Oral Irritation
    Earl Carstens; Fiscal Year: 2009
    ..In a corresponding animal study, we will determine if responses of neurons in the n. tractus solitarius (NTS), a taste relay, are reduced by intraoral capsaicin ..
  67. NPY DEPRESSION OF HIPPOCAMPAL EPILEPSY
    Anthony van den Pol; Fiscal Year: 2002
    ..NPY is potentially of great interest because its primary action in the normal hippocampus appears to be one of depressing hyperexcited neurons, without a substantial effect on normal neurotransmission. ..
  68. DJ-1 in Dopaminergic Neuronal Function and Survival
    Jie Shen; Fiscal Year: 2009
    ..Our long-term goal is to develop a genetic mouse model that recapitulates all central features of PD and to characterize the molecular pathways responsible for PD pathogenesis. ..
  69. GENETICS OF NEUROPEPTIDE Y FUNCTION
    RICHARD PALMITER; Fiscal Year: 2001
    ..These genetic experiments should help rationalize the current disparate results obtained by permanent NPY gene silencing and by acute intervention of NPY signaling. ..
  70. Planning Grant:Research on Blinding Eye Diseases (RMI)
    Darlene Dartt; Fiscal Year: 2006
    ..Based on these findings, an application for an Interdisciplinary Center for Research on Blinding Eye Diseases will be prepared. [unreadable] [unreadable]..
  71. SYNAPTIC FUNCTION OF CNG CHANNELS IN THE RETINA
    Richard Kramer; Fiscal Year: 2001
    ..Preliminary results indicate that NO produces a sag in light response of horizontal cells in the intact retina. Whether this is due to effects on cones or effects on horizontal cells will be examined. ..