Genomes and Genes
serine proteinase inhibitors
Summary: Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES.
Publications259 found, 100 shown here
- Serpin structure, mechanism, and functionPeter G W Gettins
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, M C 536, 1819 53 West Polk Street, Chicago, Illinois 60612, USA
Chem Rev 102:4751-804. 2002
- SdPI, the first functionally characterized Kunitz-type trypsin inhibitor from scorpion venomRuiming Zhao
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People s Republic of China
PLoS ONE 6:e27548. 2011..However, no Kunitz-type peptides from scorpion venom have been functionally characterized...
- Serine proteinase inhibitors in arthropod immunityM R Kanost
Department of Biochemistry, Kansas State University, Manhattan 66506, USA
Dev Comp Immunol 23:291-301. 1999..These inhibitors may exist in plasma or in hemocyte granules. Serine proteinase inhibitors from the Kazal, Kunitz, alpha-macroglobulin, and serpin families have been identified in arthropod ..
- Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra venomYing Ying He
Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China
Peptides 29:1692-9. 2008..46 x10(-8)M for trypsin and chymotrypsin, respectively. To our knowledge, it was the first report of Kunitz/BPTI serine proteinase inhibitor from snake venom that had equivalent trypsin and chymotrypsin inhibitory activities...
- An overview of the serpin superfamilyRuby H P Law
Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Melbourne VIC 3800, Australia
Genome Biol 7:216. 2006..Serpins are conformationally labile and many of the disease-linked mutations of serpins result in misfolding or in pathogenic, inactive polymers...
- Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patientMaria Cubero
Liver Unit, Department of Medicine, Hospital Universitari Vall d Hebron, Barcelona, Spain
Virology 370:237-45. 2008..Here we report the presence of the A156T mutation in close to 1% of NS3 sequences within the liver quasispecies of a chronic hepatitis C patient never treated with anti-NS3-protease inhibitors...
- Biosynthesis and structure of aeruginoside 126A and 126B, cyanobacterial peptide glycosides bearing a 2-carboxy-6-hydroxyoctahydroindole moietyKeishi Ishida
Institute of Biology, Humboldt University Berlin, 10115 Berlin, Germany
Chem Biol 14:565-76. 2007..In silico analyses of the aeruginoside biosynthetic genes aerA-aerI as well as additional mutagenesis and feeding studies allowed the prediction of enzymatic steps leading to the formation of aeruginosides and the unusual Choi moiety...
- Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory mannerT T Myöhänen
Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5E, Helsinki, Finland
Br J Pharmacol 163:1666-78. 2011..Our results also advocate a role for Ac-SDKP in angiogenesis, and suggest that POP has a pro-angiogenic role via the release of Ac-SDKP from its precursor Tβ4 and POP inhibitors can block this action...
- Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapyDavid A Lomas
Respiratory Medicine Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Cambridge, United Kingdom
J Clin Invest 110:1585-90. 2002
- SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinasesY S Askew
Department of Pediatrics, Harvard Medical School, Children s Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 276:49320-30. 2001..The second-order rate constants for the inhibitory reactions were 2.5 +/- 1.6 x 10(5) and 1.6 +/- 0.2 x 10(4) M(-1) S(-1), respectively. These data show that SERPINB12 encodes for a new functional member of the human ov-serpin family...
- Tick-Encoded serine proteinase inhibitors (serpins); potential target antigens for tick vaccine developmentA Muleng
Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
J Vet Med Sci 63:1063-9. 2001....
- Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patientsMineji Hayakawa
Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan
Shock 33:14-8. 2010..The length of ICU stay of the sivelestat group was significantly shorter than that of the control group. In addition, sivelestat administration was found to be an independent predictor of survival of those patients...
- Conformational properties of serine proteinase inhibitors (serpins) confer multiple pathophysiological rolesS Janciauskiene
Department of Medicine, Wallenberg Laboratory, Ing 46, Malmo University Hospital, S 20502, Malmo, Sweden
Biochim Biophys Acta 1535:221-35. 2001b>Serine proteinase inhibitors (Serpins) are irreversible suicide inhibitors of proteases that regulate diverse physiological processes such as coagulation, fibrinolysis, complement activation, angiogenesis, apoptosis, inflammation, ..
- The complement inhibitor FUT-175 suppresses T cell autoreactivity in experimental autoimmune encephalomyelitisQing Li
Assistant Professor, Institute of Pathology, Case Western Reserve University School of Medicine, 2085 Adelbert Road, Room 306, Cleveland, OH 44106, USA
Am J Pathol 175:661-7. 2009..These results argue that complement regulators, which inhibit C5a/C3a production, may have therapeutic efficacy in multiple sclerosis and in other clinical conditions in which T cells drive disease pathogenesis...
- Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndromeKatiuchia Uzzun Sales
National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
Nat Genet 42:676-83. 2010..These results uncover a pathogenic matriptase-pro-kallikrein pathway that could operate in several human skin and inflammatory diseases...
- Structure and function of invertebrate Kazal-type serine proteinase inhibitorsVichien Rimphanitchayakit
Center of Excellence for Molecular Biology and Genomics of Shrimp, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Phyathai Road, Bangkok 10330, Thailand
Dev Comp Immunol 34:377-86. 2010..Silk moths produce KPIs to protect their cocoon from predators and microbial destruction...
- Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virusK Morikawa
Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
J Viral Hepat 18:305-15. 2011..This review provides a concise update on the biochemical and structural aspects of NS3-4A, its role in the pathogenesis of chronic hepatitis C and the clinical development of NS3-4A protease inhibitors...
- Relative replication capacity and selective advantage profiles of protease inhibitor-resistant hepatitis C virus (HCV) NS3 protease mutants in the HCV genotype 1b replicon systemYupeng He
Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6217, USA
Antimicrob Agents Chemother 52:1101-10. 2008....
- Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis)Emma Karin I Millers
School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Australia
FEBS J 276:3163-75. 2009..5 nm versus 0.053 nm) and could also account for an observed narrower binding specificity...
- A tick protein with a modified Kunitz fold inhibits human tryptaseGuido C Paesen
CEH, Mansfield Road, Oxford, OX1 3SR, UK
J Mol Biol 368:1172-86. 2007..TdPI accumulates in the cytosolic granules of mast cells, presumably suppressing inflammation in the host animal's skin by tryptase inhibition...
- Structure and function of invertebrate Kunitz serine protease inhibitorsShiwanthi Ranasinghe
Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Dev Comp Immunol 39:219-27. 2013..Most Kunitz inhibitors in blood sucking arthropods function as anti-coagulant factors and several act as a defense against microbial pathogen invaders...
- Pretreatment of sivelestat sodium hydrate improves the lung microcirculation and alveolar damage in lipopolysaccharide-induced acute lung inflammation in hamstersToshiaki Iba
Department of Surgery, Juntendo Urayasu Hospital, Juntendo University School of Medicine, Urayasu, Chiba, Japan
Shock 26:95-8. 2006..05). Pretreatment of sivelestat demonstrated a protective effect on both intravascular and extravascular damage in the lung, whereas posttreatment only suppressed the latter damage...
- Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastaseA Belaaouaj
Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
Science 289:1185-8. 2000..coli. These findings define a mechanism of nonoxidative bacterial killing by NE and point to OmpA as a bacterial target in host defense...
- Osmolytes as modulators of conformational changes in serpinsM K Chow
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
Biol Chem 382:1593-9. 2001..The implications of these results in the context of conformational changes and states adopted by alpha1-antitrypsin are discussed...
- Serine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behaviorAntoine G Almonte
Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Brain Res 1407:107-22. 2011..In this review, we discuss emerging roles for serine proteases in the regulation of mechanisms underlying synaptic plasticity and memory formation...
- Neutrophil elastase inhibition in acute lung injury: results of the STRIVE studyBernhardt G Zeiher
Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
Crit Care Med 32:1695-702. 2004....
- Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine proteaseRobert B Perni
Vertex Pharmaceuticals Incorporated, 130 Waverly Street, Cambridge, Massachusetts 02139, USA
Antimicrob Agents Chemother 50:899-909. 2006..Therefore, the overall preclinical profile of VX-950 supports its candidacy as a novel oral therapy against hepatitis C...
- Mechanisms of synthetic serine protease inhibitor (FUT-175)-mediated cell deathTadashi Uwagawa
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 109:2142-53. 2007....
- Granzyme activity in the inflamed lung is not controlled by endogenous serine proteinase inhibitorsG M Tremblay
Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Sainte Foy, Quebec, Canada
J Immunol 165:3966-9. 2000..Hence, these data show that granzyme activity may be poorly controlled by protease inhibitors in inflamed tissues. Thus, granzymes could contribute to tissue remodeling and inflammation characterizing HP...
- Anti-hepatitis C virus drugs in developmentEsperance A K Schaefer
Massachusetts General Hospital, Department of Medicine, Gastrointestinal Unit, Boston, USA
Gastroenterology 142:1340-1350.e1. 2012..These new reagents against hepatitis C virus should lead to highly effective, well-tolerated, and likely interferon-sparing therapies in the next several years...
- Sivelestat sodium hydrate improves septic acute lung injury by reducing alveolar dysfunctionShigeatsu Endo
Department of Critical Care Medicine, Iwate Medical University, 19 1 Uchimaru, Morioka 020 8505, Japan
Res Commun Mol Pathol Pharmacol 119:53-65. 2006..Administration of sivelestat was found to reduce alveolar dysfunction and improve respiratory function, and it was suggested that early administration might be useful...
- Chymase inhibitor improves dermatitis in NC/Nga miceNaohiro Watanabe
Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan
Int Arch Allergy Immunol 128:229-34. 2002..To elucidate the possible role of chymase in AD, we examined the effect of a chymase inhibitor on skin lesions of NC/Nga mice...
- Relationship between neutrophil elastase and acute lung injury in humansShouetsu Tamakuma
National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 0042, Japan
Pulm Pharmacol Ther 17:271-9. 2004..It was concluded that neutrophil elastase may be involved in the pathogenesis of ALI in humans...
- Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infectionMahmoud M Bahgat
Department of Infection Genetics and University of Veterinary Medicine Hannover, Helmholtz Centre for Infection Research, Braunschweig, Germany
Virol J 8:27. 2011..Therefore, we studied the activity and expression of serine proteases in lungs from mice infected with influenza and evaluated the effect of serine protease inhibitors on virus replication both in cell culture and in infected mice...
- Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinomaToshiaki Wakita
Department of Molecular Pathobiology, Mie University School of Medicine, Tsu City, Mie, Japan
Int J Cancer 108:516-23. 2004..The results of our study suggest that PCI might be a potential therapeutic agent for inhibiting renal tumor invasion...
- Antifibrinolytic role of a bee venom serine protease inhibitor that acts as a plasmin inhibitorYoung Moo Choo
College of Natural Resources and Life Science, Dong A University, Busan, Republic of Korea
PLoS ONE 7:e32269. 2012....
- The human mast cell tryptase tetramer: a fascinating riddle solved by structureC P Sommerhoff
Abteilung für Klinische Chemie und Klinische Biochemie in der Chirurgischen Klinik Innenstadt, Klinikum der Ludwig Maximilians Universität, Nussbaumstrasse 20, D 80336, Munich, Germany
Biochim Biophys Acta 1477:75-89. 2000..This review solves this riddle with the help of the crystal structure of the human beta(2)-tryptase tetramer, but also indicates controversies between the unique quaternary architecture and some experimental data...
- Anti-thrombosis repertoire of blood-feeding horsefly salivary glandsDongying Ma
Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
Mol Cell Proteomics 8:2071-9. 2009..The extreme diversity of horsefly anti-thrombosis components also reveals the anti-thrombosis molecular mechanisms of the traditional Eastern medicine insect material...
- 4-(2-Aminoethyl)benzenesulfonyl fluoride attenuates tumor-necrosis-factor-alpha-induced blood-brain barrier openingP Megyeri
Department of Pediatrics, Albert Szent Gyorgyi Medical University, Szeged, Hungary
Eur J Pharmacol 374:207-11. 1999..2 mg/kg AEBSF could significantly (P < 0.05) decrease the change in Evan's blue-albumin (MW = 67,000) transport in two regions. In conclusion, AEBSF attenuates vasogenic brain edema formation...
- Purification, characterization, and localization of a novel trypsin-like protease found in the human airwayS Yasuoka
The Department of Nursing, School of Medical Sciences, The University of Tokushima, Japan
Am J Respir Cell Mol Biol 16:300-8. 1997..These results suggest that the enzyme is secreted from submucosal serous glands onto the mucous membrane in patients with chronic airway diseases...
- A clogged gutter mechanism for protease inhibitorsEvette S Radisky
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 99:10316-21. 2002..The arrest of enzymatic reaction at the intermediate stage allowed us to determine that the consensus nucleophilic attack angle is close to 90 degrees in the reactive Michaelis complexes...
- Telaprevir: a new hope in the treatment of chronic hepatitis C?Andrew J Fowell
Southampton University Hospitals Trust, Southampton, UK
Adv Ther 27:512-22. 2010..In this review, we summarize the pharmacology, pharmacokinetics, and results of phase 1 and 2 clinical trials of telaprevir, and discuss the likely role of this agent in the future management of CHC...
- Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptaseY Q Long
Laboratory of Medicinal Chemistry, National Cancer Institute, NIH, FCRDC, 376/208, PO Box B, Frederick, MD 21702, USA
Bioorg Med Chem Lett 11:2515-9. 2001..In addition to inhibiting trypsin, the synthetic SFTI-1 is also a very potent inhibitor, with a K(i) of 0.92nM, of the recently identified epithelial serine protease, termed 'matriptase'...
- Structure of a serpin-protease complex shows inhibition by deformationJ A Huntington
Department of Haematology, University of Cambridge, Wellcome Trust Centre for Molecular Mechanisms in Disease, Cambridge Institute for Medical Research, UK
Nature 407:923-6. 2000..It is this ability of the conformational mechanism to crush as well as inhibit proteases that provides the serpins with their selective advantage...
- Structural and functional study of an Anemonia elastase inhibitor, a "nonclassical" Kazal-type inhibitor from Anemonia sulcataHikaru Hemmi
National Food Research Institute, 2 1 12 Kannondai, Tsukuba, Ibaraki 305 8642, Japan
Biochemistry 44:9626-36. 2005..7 A toward the central helix to form the introduced Cys(6)-Cys(31) bond. Such a conformational change in the restricted region correlates with the specificity change of the inhibitor...
- N-tosyl-L-phenylalanine chloromethyl ketone inhibits NF-kappaB activation by blocking specific cysteine residues of IkappaB kinase beta and p65/RelAKyung Ho Ha
Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 137 701, Republic of Korea
Biochemistry 48:7271-8. 2009..These results suggest that TPCK inhibits NF-kappaB activation by directly modifying thiol groups on two different targets: Cys-179 of IKKbeta and Cys-38 of p65/RelA...
- Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthmaChih Lung Chen
Division of Biomaterial and Tissue Engineering, Industrial Technology Research Institute, Hsing Chu, Taiwan, Republic of China
J Allergy Clin Immunol 118:105-12. 2006..Serine proteases such as mast cell tryptase and certain allergens are important in the pathogenesis of allergic inflammation of asthma...
- Comparison of textilinin-1 with aprotinin as serine protease inhibitors and as antifibrinolytic agentsSimone Flight
School of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
Pathophysiol Haemost Thromb 34:188-93. 2005..9 +/- 0.7). The same trend was found with the lysis of euglobulin fractions. From these data textilinin-1 appears to be a more specific plasmin inhibitor than aprotinin but aprotinin inhibits clot lysis to a greater extent...
- Largamides A-H, unusual cyclic peptides from the marine cyanobacterium Oscillatoria spAlberto Plaza
Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0820, USA
J Org Chem 71:6898-907. 2006..Largamides D-G (4-7) inhibited chymotrypsin with IC(50) values ranging between 4 and 25 microM...
- Gabexate or somatostatin administration before ERCP in patients at high risk for post-ERCP pancreatitis: a multicenter, placebo-controlled, randomized clinical trialAngelo Andriulli
Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy
Gastrointest Endosc 56:488-95. 2002..A meta-analysis was conducted of all published studies on the use of somatostatin or gabexate for prevention of post-ERCP pancreatitis...
- Manduca sexta serpin-6 regulates immune serine proteinases PAP-3 and HP8. cDNA cloning, protein expression, inhibition kinetics, and function elucidationZhen Zou
Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, Oklahoma 74078, USA
J Biol Chem 280:14341-8. 2005..These results suggest that serpin-6 plays important roles in the regulation of immune proteinases in the hemolymph...
- Location of the protease-inhibitory region of secretory leukocyte protease inhibitorS P Eisenberg
Synergen Inc, Boulder, Colorado 80301
J Biol Chem 265:7976-81. 1990..Instead they suggest that leucine 72 is also the inhibitory site for trypsin, even though the amino acid residues at the inhibitory sites of other trypsin inhibitors are almost always either lysine or arginine...
- Expression of the secretory leukoprotease inhibitor gene in epithelial cellsT Abe
Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
J Clin Invest 87:2207-15. 1991..Overall, the SLPI gene appears to be a relatively nonpolymorphic, stable gene that is constitutively expressed at specific tissue sites, but has the potential to be modulated at both the transcriptional and posttranscriptional levels...
- Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivityPascal Descargues
INSERM U563, Paul Sabatier University, Place du Dr Baylac, 31059 Toulouse, Cedex 3, France
Nat Genet 37:56-65. 2005..This work identifies LEKTI as a key regulator of epidermal protease activity and degradation of desmoglein 1 as the primary pathogenic event in Netherton syndrome...
- Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytesNastiti Wijayanti
Institut für Klinische Immunologie und Transfusionsmedizin, Justus Liebig Universitat Giessen, Langhanstrasse 7, D 35392 Giessen, Germany
J Biol Chem 280:21820-9. 2005..The data suggest that the transcriptional induction of HO-1 gene expression by AEBSF is mediated via activation of a PKB, p38 MAPK signaling pathway...
- Identification of a serine protease as a major allergen (Per a 10) of Periplaneta americanaV T Sudha
Institute of Genomics and Integrative Biology, Delhi University Campus, Delhi, India
Allergy 63:768-76. 2008..This study was undertaken to isolate and characterize a protease from Periplaneta americana and determine its allergenicity...
- Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domainTim O Hirche
Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
J Biol Chem 279:27688-98. 2004..led to the generation of similar fragments, and cleavage was inhibited with synthetic and natural serine proteinase inhibitors. In addition, neutrophils genetically deficient in neutrophil elastase and/or cathepsin G were impaired ..
- Alpha-1-antitrypsin inhibits human immunodeficiency virus type 1L Shapiro
Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
FASEB J 15:115-122. 2001..A novel host-pathogen interaction is suggested, and an alternative strategy to treat HIV-1-related disease may be possible...
- Decline in the expression of the serine proteinase inhibitor maspin is associated with tumour progression in ductal carcinomas of the breastN Maass
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Kiel, Germany
J Pathol 195:321-6. 2001..According to in vitro data, its tumour suppressor activity is likely to involve both the modulation of cell motility/invasiveness and the inhibition of angiogenesis...
- Prophenoloxidase-activating proteinase-3 (PAP-3) from Manduca sexta hemolymph: a clip-domain serine proteinase regulated by serpin-1J and serine proteinase homologsHaobo Jiang
Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA
Insect Biochem Mol Biol 33:1049-60. 2003..These data, along with our previous results on PAP-1 and PAP-2, indicate that proPO activation by PAPs is a tightly regulated process. Individual PAPs could play different roles during immune responses and developmental processes...
- Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domainsC W Marlor
Institute of Bone and Joint Disease and Cancer, Bayer Corporation, West Haven, Connecticut 06516, USA
J Biol Chem 272:12202-8. 1997..The natural protein exhibited the same NH2 terminus as predicted from the cloned cDNA and inhibited trypsin, plasma kallikrein, and plasmin with IC50 values in the nanomolar range...
- Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effectsA Churg
Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
Lab Invest 81:1119-31. 2001..The antiproteolytic effects of these agents do not seem to be mediated by protection of endogenous alpha1AT...
- Serine protease activity in m-1 cortical collecting duct cellsLian Liu
Department of Medicine and Physiology, Tulane University Health Science Center and VA Medical Center, New Orleans, LA 70112, USA
Hypertension 39:860-4. 2002..Steroids do not alter these effects in M-1 cells. Additional proteases are likely also present in mouse collecting duct cells...
- A novel serine protease inhibitor from the venom of Vespa bicolor FabriciusXinbo Yang
College of Life Sciences, Hebei Normal University, Shijiazhuang 050016, Hebei, China
Comp Biochem Physiol B Biochem Mol Biol 153:116-20. 2009..The peptide is homologous to serine protease inhibitors isolated from venoms of Anoplius samariensis and Pimpla hypochondriaca. Bicolin showed inhibitory ability against trypsin and thrombin...
- Textilinin-1, an alternative anti-bleeding agent to aprotinin: Importance of plasmin inhibition in controlling blood lossSimone M Flight
School of Medicine, University of Queensland, Brisbane, Australia
Br J Haematol 145:207-11. 2009..Based on these data, textilinin-1 merits further investigation as a therapeutic alternative to aprotinin...
- Hepatitis C virus NS3/4A proteaseA D Kwong
Vertex Pharmaceuticals, Inc, Cambridge, MA 02139, USA
Antiviral Res 41:67-84. 1999..This review will focus on the structure and function of the serine protease activity of NS3/4A and the development of inhibitors of this activity...
- MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibitionEva Böttcher
Institut fur Virologie, Philipps Universitat Marburg, Hans Meerwein Strasse 2, 35043 Marburg, Germany
Vaccine 27:6324-9. 2009....
- Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal modelsMizuo Miyazaki
Department of Pharmacology, Osaka Medical College, 2 7, Daigakumachi, Takatsuki City, Osaka 569 8686, Japan
Pharmacol Ther 112:668-76. 2006..We propose that chymase inhibitors are effective in the prevention of multiple cardiovascular disorders, especially at the local event level without any effect on the systemic blood pressure...
- Subcellular localization and post-secretory targeting of TgPI, a serine proteinase inhibitor from Toxoplasma gondiiViviana Pszenny
Departamento de Parasitologia, ANLIS Dr Carlos G Malbran, Av Velez Sarsfield 563, 1281, Ciudad de Buenos Aires, Argentina
Mol Biochem Parasitol 121:283-6. 2002
- Ixodes scapularis tick serine proteinase inhibitor (serpin) gene family; annotation and transcriptional analysisAlbert Mulenga
Department of Entomology, Texas A and M University, 2475 TAMU, Minnie Belle Heep center, College Station, Texas 77843, USA
BMC Genomics 10:217. 2009b>Serine proteinase inhibitors (Serpins) are a large superfamily of structurally related, but functionally diverse proteins that control essential proteolytic pathways in most branches of life...
- Complementation of intramolecular interactions for structural-functional stability of plant serine proteinase inhibitorsRakesh S Joshi
Plant Molecular Biology Unit, Division of Biochemical Sciences, CSIR National Chemical Laboratory, Dr Homi Bhabha Road, Pune 411 008 MS, India
Biochim Biophys Acta 1830:5087-94. 2013..Among PIs, serine PIs (SPIs) display stability and conformational restrictions of the reactive site loop by virtue of their compact size, and by the presence of disulfide bonds, hydrogen bonds, and other weak interactions...
- Secretory leukocyte protease inhibitor interferes with uptake of lipopolysaccharide by macrophagesA Ding
Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
Infect Immun 67:4485-9. 1999..These results suggest that the inhibitory effect of SLPI on macrophage responses to LPS may, in part, be due to its blockade of LPS transfer to soluble CD14 and its interference with uptake of LPS from LPS-sCD14 complexes by macrophages...
- Inhaled recombinant alpha 1-antitrypsin ameliorates cigarette smoke-induced emphysema in the mousePhilip A Pemberton
Arriva Pharmaceuticals, Inc, Alameda, California 94501, USA
COPD 3:101-8. 2006....
- The effects of serine proteinase inhibitors on bone resorption in vitroA Tumber
Department of Orthodontics and Paediatric Dentistry, United Medical and Dental Schools of Guy s, King s and St Thomas Hospitals, University of London, London SE1 9RT, UK
J Endocrinol 178:437-47. 2003..We propose that the regulation of these various enzyme systems within bone tIssue determines the sites where bone resorption will be initiated...
- The functional repertoire of prokaryote cellulosomes includes the serpin superfamily of serine proteinase inhibitorsSeungha Kang
The MAPLE Research Initiative, Department of Animal Sciences, The Ohio State University, Columbus, OH, USA
Mol Microbiol 60:1344-54. 2006..We show here with Clostridium thermocellum ATCC 27405 that members of the serpin superfamily of serine proteinase inhibitors, which are best recognized for their conformational flexibility and co-ordination of key regulatory ..
- Expression of LEKTI domains 6-9' in the baculovirus expression system: recombinant LEKTI domains 6-9' inhibit trypsin and subtilisin AArumugam Jayakumar
Department of Head and Neck Surgery, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4095, USA
Protein Expr Purif 35:93-101. 2004..Taking LEKTI6-9' as an example, the BEVS should facilitate the structure-function analysis of naturally occurring processed LEKTI forms that have physiological relevance...
- Profiling serine hydrolase activities in complex proteomesD Kidd
The Skaggs Institute for Chemical Biology and Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Biochemistry 40:4005-15. 2001..Collectively, these studies demonstrate that chemical probes such as the biotinylated FPs can greatly accelerate both the functional characterization and molecular identification of active enzymes in complex proteomes...
- Three Kazal-type serine proteinase inhibitors from the red swamp crayfish Procambarus clarkii and the characterization, function analysis of hcPcSPI2Xin Cang Li
School of Life Sciences, Shandong University, Jinan, Shandong 250100, China
Fish Shellfish Immunol 28:942-51. 2010Three Kazal-type serine proteinase inhibitors, hcPcSPI2, hpPcSPI3, and hpPcSPI4, with complete cDNA sequences, were identified from a cDNA library of the red swamp crayfish, Procambarus clarkii...
- Nafamostat mesilate, a potent serine protease inhibitor, inhibits airway eosinophilic inflammation and airway epithelial remodeling in a murine model of allergic asthmaMasayuki Ishizaki
Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan
J Pharmacol Sci 108:355-63. 2008..These findings suggest that increased serine protease activity in the airways is involved in the development of antigen-induced allergic eosinophilic inflammation and epithelial remodeling in bronchial asthma...
- The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificityS M Waugh
The Graduate Group in Biophysics, University of California, San Francisco, California 94143 0446, USA
Nat Struct Biol 7:762-5. 2000..The substrate determinants found in this structure are shared by other members of this protein class and help to reveal the properties that define substrate specificity...
- The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastaseK Huang
Department of Biochemistry, University of Alberta, Edmonton, Canada
Structure 2:679-89. 1994..These inhibitors share 30-40% sequence identity with one another, but have virtually no sequence identity with members of any of the other families of serine proteinase inhibitors.
- Bivalent inhibition of human beta-tryptaseN Schaschke
Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152 Martinsried, Germany
Chem Biol 8:313-27. 2001..The spatial display of the four identical active sites represents an ideal basis for the rational design of bivalent inhibitors...
- Clinical trial of gabexate in the prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitisG S Xiong
Department of Gastroenterology, Renji Hospital, Shanghai Second Medical University, Shanghai, People s Republic of China
Braz J Med Biol Res 39:85-90. 2006..3%) in the gabexate group and 28 (29.5%) in the placebo group (P = 0.018). The results suggest that a 4.5-h infusion of gabexate (for a total of 300 mg) could prevent post-ERCP pancreatitis and pancreatic pain...
- The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environmentJames A Irving
The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, 3800, Clayton, Australia
Structure 11:387-97. 2003..These data provide evidence as to how this unusual serpin has adapted to fold and function in a heated environment...
- HCV-NS3 inhibitors: determination of their kinetic parameters and mechanismMaria Victoria Flores
Discovery Biology Department, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK
Biochim Biophys Acta 1794:1441-8. 2009..In the case of BILN-2061, a better fit is obtained using a one-step model, indicating that the loss of potency is due to an increase in the off-rate of the EI complex...
- Inhibitory plant serpins with a sequence of three glutamine residues in the reactive centerJørn Hejgaard
Biochemistry and Nutrition Group, BioCentrum, Technical University of Denmark, Bldg 224, DK 2800 Lyngby, Denmark
Biol Chem 386:1319-23. 2005....
- Changes in the expression of protease-activated receptor 1 and protease nexin-1 mRNA during rat nervous system development and after nerve lesionS P Niclou
Friedrich Miescher Institut, Basel, Switzerland
Eur J Neurosci 10:1590-607. 1998..No PAR1 transcript was detected in reactive astrocytes. Similar to PAR1, PN-1 mRNA which was expressed in interneurons within the facial nucleus was also decreased following facial nerve transection...
- Pancreatic enzymes in the gut contributing to lung injury after trauma/hemorrhagic shockHan Ping Shi
Department of General Surgery, Southern Hospital, First Military Medical University, Guangzhou 510515, China
Chin J Traumatol 7:36-41. 2004..To examine whether pancreatic proteolytic enzymes involve in lung injury induced by trauma/hemorrhagic shock (T/HS)...
- Serine proteases are involved in the pathogenesis of trauma-hemorrhagic shock-induced gut and lung injuryEdwin A Deitch
Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
Shock 19:452-6. 2003....
- Canonical protein inhibitors of serine proteasesD Krowarsch
Institute of Biochemistry and Molecular Biology, University of Wroclaw, Tamka 2, 50 137 Wroclaw, Poland
Cell Mol Life Sci 60:2427-44. 2003..Serpins, similarly to the canonical inhibitors, interact with their target proteases in a substrate-like manner; however, cleavage of a single peptide bond in the binding loop leads to dramatic structural changes...
- Structure-activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinaseShyama Sidique
Conrad Prebys Center for Chemical Genomics, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
Bioorg Med Chem Lett 19:5773-7. 2009..We now report the design, synthesis and in vitro evaluation of pyrazole derivatives that are inhibitors of WNV NS2B-NS3 proteinase with greatly improved stability in the assay medium...
- Nafamostat mesilate inhibits high-mobility group box 1 by lipopolysaccharide stimulation in murine macrophage RAW 264.7Satoshi Hagiwara
Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, Yufu City, Oita, Japan
Shock 27:429-35. 2007..Our findings thus suggest that the administration of NM may therefore potentially improve the condition of patients who have septic shock...
- Purification, characterization and cloning of a chymotrypsin inhibitor (CI-9) from the hemolymph of the silkworm, Bombyx moriPing Zhao
The Key Sericultural Laboratory of Agricultural Ministry, Southwest University, Chongqing, 400716, China
Protein J 26:349-57. 2007..The difference of sequence and pI between CI-9 and other Kunitz type CIs indicated that it is a novel chymotrypsin inhibitor...
- Expression, purification and characterization of a three-domain Kazal-type inhibitor from silkworm pupae (Bombyx mori)Qing Liang Zheng
College of Life Science, Zhejiang Sci Tech University, Hangzhou, China
Comp Biochem Physiol B Biochem Mol Biol 146:234-40. 2007..35 nM and the inhibitor seemed to form a 1:1 complex with subtilisin A. This is a first description of the structure and characterization of Kazal-type inhibitor with three domains cloned from silkworm pupae, B. mori...
- Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV studyNaoki Aikawa
Department of Emergency and Critical Care Medicine, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo, Japan
Pulm Pharmacol Ther 24:549-54. 2011..The Pharmaceuticals and Medical Devices Agency (PMDA) has ordered to conduct a postmarket clinical study in order to reevaluate the efficacy and safety of Sivelestat in actual clinical settings in Japan...
- Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthmaM T Krishna
University of Southampton, Southampton General Hospital, Mail Point 810, Tremona Road, Southampton SO16 6YD, UK
J Allergy Clin Immunol 107:1039-45. 2001..CONCLUSION: Short-term repeated administration of APC 366 significantly reduced the magnitude of antigen-induced LAR in atopic asthmatics, which supports the role of mast cell tryptase in the pathophysiology of the LAR...
- Tryptase inhibition blocks airway inflammation in a mouse asthma modelSe Woong Oh
Department of Medicine, University of Washington, Seattle, WA 98195, USA
J Immunol 168:1992-2000. 2002..These results support tryptase as a therapeutic target in asthma and indicate that selective tryptase inhibitors can reduce allergic airway inflammation...
- Antiplasmin: the forgotten serpin?Paul B Coughlin
Australian Centre for Blood Diseases, Monash University, Prahran
FEBS J 272:4852-7. 2005..Studies of mice with targeted deletion of antiplasmin have confirmed its importance as a major regulator of fibrinolysis and re-emphasized its value as a potential therapeutic target...
- Aprotinin and preservation of myocardial function after ischemia-reperfusion injuryDavid A Bull
Department of Surgery, Division of Cardiothoracic Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
Ann Thorac Surg 75:S735-9. 2003..In all, review of this topic indicates that aprotinin may reduce aspects of ischemia-reperfusion injury and prospective clinical studies are needed to evaluate the impact of aprotinin on associated patient outcomes...
- Crystal structure of thrombin-ecotin reveals conformational changes and extended interactionsS X Wang
Graduate Program in Chemistry and Chemical Biology, University of California, San Francisco, California 94143 0446, USA
Biochemistry 40:10038-46. 2001..The preference for a Val at P4 is clearly defined. The insertion at residue 60 may further affect substrate binding by moving its adjacent loops that are part of the substrate recognition sites...
- The absolute structural requirement for a proline in the P3'-position of Bowman-Birk protease inhibitors is surmounted in the minimized SFTI-1 scaffoldNorelle L Daly
Institute for Molecular Bioscience and Australian Research Council Special Research Centre for Functional and Applied Genomics, The University of Queensland, Brisbane, Queensland 4072, Australia
J Biol Chem 281:23668-75. 2006..Overall, this mutational analysis of SFTI-1 clearly defines the optimized nature of the SFTI-1 scaffold and demonstrates the importance of the secondary loop in maintaining the active conformation of the binding loop...
- Therapeutic Potential of A Novel Angiogenic InhibitorJames Ryan; Fiscal Year: 2003..It belongs to the family of serine proteinase inhibitors (serpin) and has significant sequence homology with the potent angiogenic inhibitor, PEDF...
- Structural examination of serpin-protein interactionsPETER GETTINS; Fiscal Year: 2009Although protein serine proteinase inhibitors of the Kunitz, Kazal, and Bowman-Birk families make do with lock-and-key type interactions to inhibit target proteinases, serpins have now been shown by x-ray crystallography, NMR ..
- Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory TherALEXANDRA ROSE LUCAS; Fiscal Year: 2010..protease enzymes in the clot lysis pathway initiate collagen breakdown and aneurysm formation and serine proteinase inhibitors (serpins) protect against protease activation...
- Plasminogen activator inhibitor-1 in tumor progression and metastasisYves A DeClerck; Fiscal Year: 2013....
- Serine Proteinase Inhibitors (Serpins) in Tick Feeding and PhysiologyAlbert Mulenga; Fiscal Year: 2009..One important such class of proteins, are serine proteinase inhibitors that are commonly referred to by its acronym "serpin", which is the largest class of proteinase ..
- CTL EFFECTOR MECHANISMS IN ADENOVIRAL HEPATITISDWAIN LOUIS THIELE; Fiscal Year: 2010..In proposed studies, we will determine the repertoire of serine proteinase inhibitors (serpins) expressed in normal and virally infected murine hepatocytes and determine the role of ..
- SERINE PROTEINASE INHIBITORS IN INSECTSMichael Kanost; Fiscal Year: 1993Human plasma contains a superfamily of serine proteinase inhibitors, the serpins, which are glycoproteins of Mr = 40,000- 60,000...
- Poxvirus proteins involved in virion binding, membrane fusion, & entry into cellsRichard Moyer; Fiscal Year: 2007..We focus here on poxvirus- encoded serine proteinase inhibitors (serpins)...
- Anti-inflammatory Serpin(AAT and Elafin) Gene Transfers*Sihong Song; Fiscal Year: 2003..Alpha 1 antitrypsin (AAT) and elafin are serine proteinase inhibitors (serpin), and have anti-inflammatory properties...
- CELL RECEPTORS IN COAGULATION AND ATHEROGENESISSALVATORE PIZZO; Fiscal Year: 2001..The scope of the proposal has been narrowed from previous years where projects focused on serine proteinase inhibitors, inter-alpha-trypsin inhibitor, chemically synthesized inhibitors of coagulation factors and alpha2M...
- SERPIN INTERACTION WITH SERINE PROTEINASESBARRY COOPERMAN; Fiscal Year: 2006DESCRIPTION (provided by applicant): Serine proteinase inhibitors (serpins) play a central role in a wide variety of physiologic processes involved in aging...
- THIOESTERASE IIH--A NOVEL PROTEIN IN HIV INFECTIVITYZygmunt Derewenda; Fiscal Year: 2000..the typical GXSXG sequence motif that is present in serine hydrolases, and it is not susceptible to serine proteinase inhibitors. Histidine 58 has been implicated in the catalytic mechanism but no details are known...
- SERINE PROTEINASE INHIBITORS IN OCULAR SURFACE EPITHELIAROBERT LAVKER; Fiscal Year: 2003..These studies will serve as a baseline for future studies on the therapeutic use of PAI-2 in ophthalmology. ..
- 3rd Intl Symp on Serpin Biology, Structure and FunctionPETER GETTINS; Fiscal Year: 2002..v) To provide an opportunity for promising junior scientists and minorities to play a major role in the meeting. ..
- Signaling Pathways in Hepatic FibrogenesisBruce Bacon; Fiscal Year: 2005..Since activated HSC play a key role in hepatic fibrogenesis, these experiments will contribute to an improved understanding of the basic biochemical processes underlying hepatic fibrosis. ..
- ACQUISITION OF CRYOPROBE FOR 600 MHZ NMR SPECTROMETERPETER GETTINS; Fiscal Year: 2001..Olson, with interests in serpin inhibition mechanism, Dr. Patston, with interests in the structure of the serpin angiotensinogen, and Dr. Silver, who is characterizing a unique silver binding protein, silE. ..
- FUNCTION AND DYSFUNCTION IN HUMAN ANTITHROMBINSPETER GETTINS; Fiscal Year: 2007..For antithrombins that have been activated by mutation,[unreadable] x-ray crystallography, through collaboration with Dr. Robin Carrell,[unreadable] will be used.[unreadable]..
- ULTRASENSITIVE CALORIMETRY SYSTEM FOR BIOMOLECULESPETER GETTINS; Fiscal Year: 2001..abstract_text> ..
- 900MHz NMR for Structural Biology in ChicagoPETER GETTINS; Fiscal Year: 2007..As part of the facility, a resource will be established for development of procedures for intein-based segmental isotopic labeling of proteins, as well as for production of segmentally labeled DNA and RNA species. ..
- Polymer Carrier for Ischemia-Inducible Gene TherapyDavid Bull; Fiscal Year: 2007..abstract_text> ..
- Protein interactions by analytical ultracentrifugationPETER GETTINS; Fiscal Year: 2007..The knowledge gained will be invaluable for design of therapeutics against such infections or in amelioration of diseases associated with aberrant functioning of processes such as blood coagulation. [unreadable] [unreadable] [unreadable]..
- Development of a combination therapy for the treatment of prostate cancerFRANCIS MARKLAND; Fiscal Year: 2007..These studies will advance the clinical potential of this novel anticancer protein. [unreadable] [unreadable] [unreadable]..
- Chemoprevention Potential of Calpain InhibitorsISAAC DONKOR; Fiscal Year: 2007..The proposal is significant and innovative because it seeks to investigate calpain as a pharmacological target for the discovery of a new class of chemoprevention agents. [unreadable] [unreadable] [unreadable]..
- KALLISTATIN IN HYPERTENSIONJulie Chao; Fiscal Year: 2008..abstract_text> ..
- MOLECULAR GENETICS OF HEREDITARY PANCREATITISDavid Whitcomb; Fiscal Year: 2008..The HP and familial pancreatitis studies are especially important because of the statistical power of family studies and the ability to detect modifier genes in a uniform background of susceptibility factors. ..
- Resolution of Gouty InflammationSTEPHEN MALAWISTA; Fiscal Year: 2008..We suggest further that this reprogramming of lipid mediators may explain in part the action of therapeutic agents such as colchicine, and could lead to better treatment for this condition. [unreadable] [unreadable] [unreadable]..
- Reducing Risk Factors in Peripheral Arterial DiseaseMary Mcgrae McDermott; Fiscal Year: 2010....
- Molecular Genetics of Cadmium ToxicityDaniel W Nebert; Fiscal Year: 2010....
- Magnetic Resonance in Peripheral Arterial DiseaseMary Mcgrae McDermott; Fiscal Year: 2010..This knowledge, in subsequent studies, is expected to lead to new therapies for PAD-related functional impairment and functional decline. ..
- Plasminogen activators and cerebral ischemic injuryWilliam M Armstead; Fiscal Year: 2010....
- POMC Processing and Beta-Endorphine-Related Opioid PeptidesVivian Y H Hook; Fiscal Year: 2010..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
- Hepcidin and the pathogenesis of anemia in older adults.Richard D Semba; Fiscal Year: 2010..This study should provide new insight into the epidemiology and biological mechanisms of anemia among older adults and help identify strategies aimed at the prevention and treatment of anemia. ..
- ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIAYuping Wang; Fiscal Year: 2010..The influence of CLP on placental sFlt-1 will be studied. Results obtained from the proposed work should enhance current knowledge of the role of the placenta and EC dysfunction in the pathogenesis of PE. ..
- Oxidative Stress and the Pathogenesis of Sarcopenia and Disability in Older WomenRichard Semba; Fiscal Year: 2008..AGEs are a potentially modifiable risk factor, as circulating AGEs can be lowered by dietary modification and by pharmacological intervention. ..
- Genetics of Asthma Severity and Lung Function DeclineNadia Hansel; Fiscal Year: 2008..Hansel new knowledge, skills and collaborative relationships necessary to successfully apply for funding as an independent investigator during the fourth year of this award. ..
- Liposomal Disintegrin: Novel and Effective Antitumor Agent Phase IFRANCIS MARKLAND; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Tissue Kallikrein, Oxidative Stress and Renal FibrosisJulie Chao; Fiscal Year: 2007..abstract_text> ..
- THE CRES GENE IN REPRODUCTIONGail Cornwall; Fiscal Year: 2005..abstract_text> ..
- ADJUNCT VITAMIN A THERAPY FOR TUBERCULOSIS AND HIV/AIDSRichard Semba; Fiscal Year: 2005....
- Computer Directed Photodynamic Therapy of Prostate CaJerzy Jankun; Fiscal Year: 2005....
- Proteomics/Genomics of Opiate Analgesia and AddictionVivian Hook; Fiscal Year: 2004..Elucidation of distinct pathways will be significant, since it could allow future design of opiate drug regimens that provide effective analgesia, without the tolerance and dependence of addiction. ..
- BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMESMary McDermott; Fiscal Year: 2004....
- LYME DISEASE--HOST PARASITE INTERACTIONSSTEPHEN MALAWISTA; Fiscal Year: 2003..These studies may provide the technical and conceptual basis for improvements in diagnostic and prognostic aspects of inflammatory diseases. ..
- APPROACHES TO THE GENETICS OF COPDEdwin Silverman; Fiscal Year: 2003..abstract_text> ..
- PROBING THE S' SUBSITES OF CALPAINISAAC DONKOR; Fiscal Year: 2002..Selected potent and cell permeable inhibitors will be tested in the rat isolated heart ischemia model for cardioprotective effect. ..
- PERIPHERAL ARTERIAL DISEASE AND FUNCTIONAL OUTCOMESMary McDermott; Fiscal Year: 2001..They further state that the results of this study will be used to develop subsequent intervention studies designed to improve quality of life and prevent functional decline among men and women with PAD. ..
- CD8 CELL DYSFUNCTION IN HIV INFECTIONJudy Lieberman; Fiscal Year: 2005..In vitro experiments will be performed to dissect the relative importance of signaling and perforin defects in impaired HIV-specific cytotoxicity and to explore what factors regulate and can reverse impaired CD8 T cell function. ..
- MMP-2 in Periodontal Disease and Oral CancerBjorn Steffensen; Fiscal Year: 2005....
- MECHANISMS OF NOVEL ANTI-INFLAMMATORY ACTIONS OF SLPIAihao Ding; Fiscal Year: 2007..unreadable] [unreadable]..
- Pathogenesis of Obesity and Metabolic SyndromeJAY HORTON; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Anti-Inflammatory Role of Alpha-1 Antitrypsin in LungMark Brantly; Fiscal Year: 2006..A K24 award would allow the investigator to integrate these research efforts into a mentoring program designed to interest and train young investigators in all aspects of patient-oriented research. ..
- CHOLINERGIC INSECTICIDE TOXICOLOGYJOHN CASIDA; Fiscal Year: 2006....
- Taskforce for Obesity Research at Southwestern (RMI)JAY HORTON; Fiscal Year: 2006..unreadable] [unreadable]..
- Organophosphorus Pesticide ToxicologyJOHN CASIDA; Fiscal Year: 2006..Knowledge gained on OP pesticide toxicology is also applicable to OP nerve gases as chemical warfare and terrorism agents. ..
- BARI II - FIBRINOLYSIS AND COAGULATION COREBurton Sobel; Fiscal Year: 2006..The investigators further expect that this collaborative effort will translate into a new practical clinical paradigm that will be used for treatment of Type II diabetic patients. ..
- A Beta Vaccination: Mechanisms and Therapautic ImpactLennart Mucke; Fiscal Year: 2005..Lastly, the proposed project will shed light on the roles of microglia in the pathogenesis of AD-related neuronal deficits. These goals and perspectives are congruent with those of RFA AG-01-003. ..
- Symposium on Retinal/ Choroidal AngiogenesisJohn Penn; Fiscal Year: 2004..J. Donald M. Gass, M.D. has agreed to write an introduction. In this application we request funds to support travel and registration costs of 20 young investigators and 2 keynote speakers. ..
- INTEGRATED DNA SEQUENCING SYSTEMVivian Hook; Fiscal Year: 2002..abstract_text> ..
- DEVELOPMENT OF LIGAND ASSISTED ASYMMETRIC SYNTHESESArun Ghosh; Fiscal Year: 2001..Besides the broad range of scope and generality, this line of research will provide excellent opportunities to teach and train graduate and undergraduate students in the laboratory. ..