Genomes and Genes
cysteine proteinase inhibitors
Summary: Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.
Publications300 found, 100 shown here
- The cystatins: protein inhibitors of cysteine proteinasesV Turk
Department of Biochemistry, Jozef Stefan Institute, Ljubljana, Slovenia, Yugoslavia
FEBS Lett 285:213-9. 1991....
- Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteinsP van Kerkhof
Department of Cell Biology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands
Mol Biol Cell 12:2556-66. 2001..The data suggest that the ubiquitin-proteasome pathway is involved in an endosomal sorting step of selected membrane proteins to lysosomes, thereby providing a mechanism for regulated degradation...
- Falcipains and other cysteine proteases of malaria parasitesPhilip J Rosenthal
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
Adv Exp Med Biol 712:30-48. 2011..cysteine protease inhibitors have demonstrated potent antimalarial effects and the optimization and testing of falcipain inhibitor antimalarials is underway...
- Cysteine proteinase inhibitors stefin A, stefin B, and cystatin C in sera from patients with colorectal cancer: relation to prognosisJ Kos
Jozef Stefan Institute, Department of Biochemistry and Molecular Biology, Ljubljana, Slovenia
Clin Cancer Res 6:505-11. 2000The levels of cysteine proteinase inhibitors stefin A, stefin B, and cystatin C were determined using ELISAs in sera obtained preoperatively from 345 patients with colorectal cancer and in control sera from 125 healthy blood donors...
- Impairment of the ubiquitin-proteasome system by protein aggregationN F Bence
Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020, USA
Science 292:1552-5. 2001....
- The Plasmodium circumsporozoite protein is proteolytically processed during cell invasionAlida Coppi
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY 10010, USA
J Exp Med 201:27-33. 2005..Inhibitors of CSP processing inhibit cell invasion in vitro, and treatment of mice with E-64, a highly specific cysteine protease inhibitor, completely inhibits sporozoite infectivity in vivo...
- Irreversible inhibitors of serine, cysteine, and threonine proteasesJames C Powers
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332 0400, USA
Chem Rev 102:4639-750. 2002
- Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infectionJ C Engel
Department of Pathology, University of California San Francisco, California 94143, USA
J Exp Med 188:725-34. 1998..No abnormalities were noted in the Golgi complex of host cells. This study provides proof of concept that cysteine protease inhibitors can be given at therapeutic doses to animals to selectively arrest a parasitic infection...
- Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodiesKarianne E Longva
Institute of Pathology, The University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
J Cell Biol 156:843-54. 2002..Immuno-EM showed the localization of intact EGFR on internal membranes of MVBs. This demonstrates that the EGFR as such is not the proteasomal target...
- Functions of propeptide parts in cysteine proteasesBernd Wiederanders
Institute of Biochemistry, Klinikum, Friedrich Schiller University Jena, Nonnenplan 2, D 07743 Jena, Germany
Curr Protein Pept Sci 4:309-26. 2003..The function of propeptides of two other important classes of cysteine peptidases - the calpains, clan CA family C4, and the caspases, clan CD family C 14 - are not considered in this review...
- Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparumPuran S Sijwali
Department of Medicine, San Francisco General Hospital, University of California San Francisco, CA 94143 0811, USA
Mol Biochem Parasitol 150:96-106. 2006..Our data suggest key roles for falcipain-2 and falcipain-3 in the development of erythrocytic malaria parasites and a complex interplay between P. falciparum cysteine and aspartic proteases...
- Two cysteine proteinase inhibitors from Arabidopsis thaliana, AtCYSa and AtCYSb, increasing the salt, drought, oxidation and cold toleranceXinxin Zhang
Asian Natural Environment Science Center, The University of Tokyo, Midori Cho 1 1 1, Nishitokyo City, Tokyo, Japan
Plant Mol Biol 68:131-43. 2008Two cysteine proteinase inhibitors (cystatins) from Arabidopsis thaliana, designated AtCYSa and AtCYSb, were characterized. Recombinant GST-AtCYSa and GST-AtCYSb were expressed in Escherichia coli and purified...
- Calpain mediates progressive plasma membrane permeability and proteolysis of cytoskeleton-associated paxillin, talin, and vinculin during renal cell deathXiuli Liu
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
J Pharmacol Exp Ther 304:63-70. 2003..These results suggest that calpain mediates increased plasma membrane permeability and hydrolysis of cytoskeleton-associated paxillin, vinculin, and talin during renal cell death...
- Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathwayM Jost
Department of Dermatology and Cutaneous Biology and the Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Mol Biol Cell 12:1519-27. 2001..These results demonstrate that EGFR activation contributes to anchorage-independent epithelial cell survival and identify MAPK activation as an important mechanism in this process...
- The protease inhibitor cystatin C is differentially expressed among dendritic cell populations, but does not control antigen presentationDima El-Sukkari
The Walter and Eliza Hall Institute of Medical Research, Victoria, Melbourne, Australia
J Immunol 171:5003-11. 2003..Our results also show that CyC expression can differ markedly between closely related cell types, suggesting the existence of hitherto unrecognized mechanisms of control of CyC expression...
- Protective mechanisms by cystatin C in neurodegenerative diseasesSebastien Gauthier
Nathan S Kline Institute, Orangeburg, NY 10962, USA
Front Biosci (Schol Ed) 3:541-54. 2011..These data suggest that CysC is a therapeutic candidate that can potentially prevent brain damage and neurodegeneration...
- Proteinaceous cysteine protease inhibitorsG Dubin
Faculty of Biotechnology, Jagiellonian University, ul Gronostajowa 7, 30 387, Krakow, Poland
Cell Mol Life Sci 62:653-69. 2005..The work primarily highlights biological processes in which the inhibitors are involved and focuses on pathologies resulting from aberrant protease-inhibitor balance, pointing out emerging possibilities for their correction...
- Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradationD S Campbell
Department of Anatomy, University of Cambridge, Downing Street, CB2 3DY, Cambridge, United Kingdom
Neuron 32:1013-26. 2001..These results suggest that guidance molecules steer axon growth by triggering rapid local changes in protein levels in growth cones...
- Characterization of the entire cystatin gene family in barley and their target cathepsin L-like cysteine-proteases, partners in the hordein mobilization during seed germinationManuel Martinez
Centro de Biotecnología y Genómica de Plantas, Universidad Politecnica de Madrid, Campus Montegancedo Universidad Politécnica de Madrid, 28223 Pozuelo de Alarcon, Madrid, Spain
Plant Physiol 151:1531-45. 2009..The opposite pattern of transcription expression in gibberellin-treated aleurones presented by inhibitors and enzymes allowed proteases to specifically degrade B, C, and D hordeins stored in the endosperm of barley seeds...
- Murine cytomegalovirus m38.5 protein inhibits Bax-mediated cell deathIgor Jurak
Division of Viral Infections, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
J Virol 82:4812-22. 2008..Moreover, the fact that MCMV-infected cells are protected from both Bak- and Bax-mediated cell death suggests that MCMV possesses an additional, as-yet-unidentified mechanism to block Bak-mediated apoptosis...
- Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7M Yokouchi
Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Biol Chem 274:31707-12. 1999..This mechanism participates in the down-regulation of tyrosine kinase receptors and loss of this function, as occurs in the naturally occurring 70Z-Cbl isoform, probably contributes to oncogenic transformation...
- Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson diseaseNoriyuki Yamamoto
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
J Biol Chem 282:4364-72. 2007..These data suggest that proteasome inhibition afforded cytoprotection against oxidative stress by the elevation of glutathione content, and its elevation was mediated by p38 MAPK phosphorylation...
- Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypesD A Matthews
Agouron Pharmaceuticals, Inc, 3565 General Atomics Court, San Diego, CA 92121, USA
Proc Natl Acad Sci U S A 96:11000-7. 1999..Recently, one compound in this series, AG7088, has entered clinical trials...
- Multifunctional role of plant cysteine proteinasesMałgorzata Grudkowska
Plant Physiology and Biochemistry Department, Plant Breeding and Acclimatization Institute, Radzikow, Warsaw, Poland
Acta Biochim Pol 51:609-24. 2004..In this review an attempt was undertaken to illustrate these multiple roles of cysteine proteinases and the mechanisms underlying their action...
- Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosisAlessio Nencioni
Massachusetts Institute of Technology, Department of Biology, Center for Cancer Research, Cambridge, MA, USA
Blood 105:3255-62. 2005..Pharmacologic or genetic approaches targeting Mcl-1, including therapeutic RNAi, may increase the effectiveness of these compounds...
- Inhibition of human caspases by peptide-based and macromolecular inhibitorsM Garcia-Calvo
Department of Enzymology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
J Biol Chem 273:32608-13. 1998....
- Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathwayA Mathew
Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
Mol Cell Biol 18:5091-8. 1998....
- Cysteine protease inhibitors as chemotherapy for parasitic infectionsJ H McKerrow
Department of Pathology, VA Medical Center, University of California, San Francisco 94121, USA
Bioorg Med Chem 7:639-44. 1999..This suggests that cysteine protease inhibitors may provide an alternative to traditional therapy in drug-resistant organisms...
- Mutations in reovirus outer-capsid protein sigma3 selected during persistent infections of L cells confer resistance to protease inhibitor E64G S Baer
Department of Microbiology and Immunology, and Elizabeth B Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Virol 71:4921-8. 1997....
- Caspase inhibitorsP G Ekert
The Walter and Eliza Hall Institute of Medical Research, c o Post Office Royal Melbourne Hospital, Victoria 3050, Australia
Cell Death Differ 6:1081-6. 1999....
- Plasmodium yoelii inhibitor of cysteine proteases is exported to exomembrane structures and interacts with yoelipain-2 during asexual blood-stage developmentYing Pei
Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109, USA
Cell Microbiol 15:1508-26. 2013..These data show that ICP may be important in regulating proteolytic processes during blood-stage development, and is likely playing a role in liver stage-hepatocyte interactions at the time of exoerythrocytic merozoite release. ..
- Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosisR U Jänicke
Institute of Molecular and Cell Biology, The National University of Singapore, 30 Medical Dr, Singapore 117609, Republic of Singapore
J Biol Chem 273:15540-5. 1998....
- Identification and characterization of a Drosophila proteasome regulatory networkJosefin Lundgren
Department of Molecular Biology and Functional Genomics, Stockholm University, S 106 91 Stockholm, Sweden
Mol Cell Biol 25:4662-75. 2005..Transfer of the 5' UTR from the proteasome subunit Rpn1/S2 to a noninducible promoter was sufficient to confer transcriptional upregulation of the reporter mRNA after proteasome inhibition...
- Human cystatin C forms an inactive dimer during intracellular trafficking in transfected CHO cellsG S Merz
New York State Office of Mental Retardation and Developmental Disabilities, Staten Island, New York, NY 10314, USA
J Cell Physiol 173:423-32. 1997..Similarly, its uptake by the cell also leads to its redimerization in the lysosomal pathway...
- Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expressionA Eggert
Division of Oncology, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA
Cancer Res 61:1314-9. 2001..Because many cytotoxic drugs induce caspase-dependent apoptosis, failure to express caspase-8 and/or caspase-10 might be an important mechanism of resistance to chemotherapy in NB...
- The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-alpha-initiated apoptosisJ Delic
Laboratoire de Recherche Correspondant No2 du CEA DSV DRR, Fontenay Aux Roses Institut Curie, Paris, France
Br J Cancer 77:1103-7. 1998....
- Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytesAnnika Rennenberg
Bernhard Nocht Institute for Tropical Medicine, Department of Molecular Parasitology, Hamburg, Germany
PLoS Pathog 6:e1000825. 2010....
- Evidence that a rapidly turning over protein, normally degraded by proteasomes, regulates hsp72 gene transcription in HepG2 cellsM Zhou
Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
J Biol Chem 271:24769-75. 1996..Overall, our results suggest that a rapidly turning over protein that is normally degraded by proteasomes may be involved in the regulation of Hsp70 synthesis via effects on the hsp70 transcriptional factor, HSF1...
- Inhibition of programmed cell death impairs in vitro vascular-like structure formation and reduces in vivo angiogenesisInmaculada Segura
Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Campus de Cantoblanco, E 28049 Madrid, Spain
FASEB J 16:833-41. 2002..This evidence indicates that endothelial cell apoptosis may be relevant for precise vascular tissue rearrangement in in vitro and in vivo angiogenesis...
- Falcipains, Plasmodium falciparum cysteine proteases as key drug targets against malariaC Teixeira
Centro de Investigação em Química da Universidade do Porto, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, R Campo Alegre, 687, P 4169 007 Porto, Portugal
Curr Med Chem 18:1555-72. 2011....
- Identification of lead compounds targeting the cathepsin B-like enzyme of Eimeria tenellaMarie Schaeffer
Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, 120 University Place, Glasgow, Scotland, United Kingdom
Antimicrob Agents Chemother 56:1190-201. 2012..The oxazolone scaffold is a novel cysteine peptidase inhibitor; it may thus find widespread use...
- Cystatins up-regulate nitric oxide release from interferon-gamma-activated mouse peritoneal macrophagesL Verdot
Laboratoire d Enzymologie et de Chimie des Protéines, Universite Francois Rabelais, F37032 Tours, France
J Biol Chem 271:28077-81. 1996..demonstrate that members of all 3 cystatin families share another common property unrelated to their function of cysteine proteinase inhibitors, i.e. up-regulation of NO production, which biological significance remains to be elucidated.
- FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complexM Muzio
University of Michigan Medical School Department of Pathology, Ann Arbor, Michigan 48109, USA
Cell 85:817-27. 1996..Taken together, this is unique biochemical evidence to link a death receptor physically to the proapoptotic proteases of the ICE/CED-3 family...
- Cruzain : the path from target validation to the clinicMohammed Sajid
Afd Parasitologie, Leiden University Medical Center, Leiden, The Netherlands
Adv Exp Med Biol 712:100-15. 2011....
- Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brainChanglian Zhu
Perinatal Center, Department of Physiology, Goteborg University, Goteborg, Sweden
J Neurochem 86:306-17. 2003..In summary, AIF-mediated cell death may be an important mechanism of HI-induced neuronal loss in the immature brain...
- Inhibition of Plasmodium falciparum oocyst production by membrane-permeant cysteine protease inhibitor E64dS Eksi
Department of Biology, Loyola University Chicago, 6525 N Sheridan Rd, Chicago, IL 60626, USA
Antimicrob Agents Chemother 51:1064-70. 2007..The ability of a membrane-permeant cysteine protease inhibitor to significantly reduce malaria parasite transmission suggests that future drug design should include evaluation of gametogenesis and sporogonic development...
- Expression, purification, and inhibitory activities of mouse cytotoxic T-lymphocyte antigen-2alphaMitsuhiro Kurata
Laboratory of Biochemistry and Radiation Biology, Department of Veterinary Sciences, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753 8515, Japan
Protein Expr Purif 32:119-25. 2003..Our results indicate that mouse CTLA-2alpha is a selective inhibitor of the cathepsin L-like cysteine proteinases...
- Peptidomimetic inhibitors of cathepsin KW Cameron Black
Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Que, Canada
Curr Top Med Chem 10:745-51. 2010..Three of these compounds have progressed into clinical trials and one, odanacatib (5), is currently in Phase III studies for the treatment of post-menopausal osteoporosis...
- Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin LT Bevec
Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia
J Exp Med 183:1331-8. 1996..The Ii inhibitory fragment shows no sequence homology with the known cysteine protease inhibitors, and may, therefore, represent a new class...
- Bombyx cysteine proteinase inhibitor (BCPI) homologous to propeptide regions of cysteine proteinases is a strong, selective inhibitor of cathepsin L-like cysteine proteinasesM Kurata
Laboratory of Biochemistry and Radiation Biology, Department of Veterinary Sciences, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753-8515, Japan
J Biochem 130:857-63. 2001..Recombinant BCPI lacking the two C-terminal amino acid residues still retained substantial inhibitory activity. Our results indicate that BCPI is a stable and highly selective inhibitor of cathepsin L-like cysteine proteinases...
- Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injurySusan M Knoblach
Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
J Cereb Blood Flow Metab 24:1119-32. 2004..These data suggest that neuroprotection by z-DEVD-fmk may, in part, reflect inhibition of calpain-related necrotic cell death...
- Differential effects of caspase inhibitors on endotoxin-induced myocardial dysfunction and heart apoptosisH Fauvel
, Lille Cedex, 59045, France
Am J Physiol Heart Circ Physiol 280:H1608-14. 2001..Caspase inhibition strategy may represent a therapeutic approach to endotoxin-induced myocardial dysfunction...
- Crystal structure of calcium bound domain VI of calpain at 1.9 A resolution and its role in enzyme assembly, regulation, and inhibitor bindingG D Lin
Center for Macromolecular Crystallography, University of Alabama at Birmingham 35294, USA
Nat Struct Biol 4:539-47. 1997..The crystal structure of a Ca2+ bound domain VI-inhibitor (PD150606) complex has been refined to 2.1 A resolution. A possible mode for calpain inhibition is discussed...
- Synthesis and biological evaluation of reversible inhibitors of IdeS, a bacterial cysteine protease and virulence determinantKristina Berggren
Department of Chemistry, Medicinal Chemistry, University of Gothenburg, Goteborg, Sweden
Bioorg Med Chem 17:3463-70. 2009..Eight compounds were identified as inhibitors of IdeS in an in vitro assay. The most potent compounds contained an aldehyde function, thus acting as efficient reversible inhibitors, nitrile and azide derivatives showed moderate activity...
- Expression of type 2 cystatin genes CST1-CST5 in adult human tissues and the developing submandibular glandD P Dickinson
Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912 1124, USA
DNA Cell Biol 21:47-65. 2002....
- Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosisDelphine Milhas
INSERM U466, Institut Louis Bugnard, Toulouse, France
J Biol Chem 280:19836-42. 2005..Altogether, our data strongly suggest that caspase-10 can serve as an initiator caspase in Fas signaling leading to Bid processing, caspase cascade activation, and apoptosis...
- Successful therapy of lethal murine visceral leishmaniasis with cystatin involves up-regulation of nitric oxide and a favorable T cell responseL Das
Molecular Cell Biology Laboratory, Indian Institute of Chemical Biology, Calcutta, India
J Immunol 166:4020-8. 2001..These studies provide a promising alternative for protection against leishmaniasis with a switch of CD4(+) differentiation from Th2 to Th1, indicative of long-term resistance...
- Proteasomal inhibition enhances glucocorticoid receptor transactivation and alters its subnuclear traffickingBonnie J Deroo
Chromatin and Gene Expression Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Mol Cell Biol 22:4113-23. 2002..Proteasomes may therefore impact steroid receptor action at multiple levels and exert distinct effects on individual receptor types...
- Signaling events leading to the curative effect of cystatin on experimental visceral leishmaniasis: involvement of ERK1/2, NF-kappaB and JAK/STAT pathwaysSusanta Kar
Infectious Diseases and Immunology Division, Molecular Cell Biology Laboratory, Indian Institute of Chemical Biology, Kolkata, India
Eur J Immunol 39:741-51. 2009..Understanding the molecular mechanisms through which cystatin modulates macrophage effector responses will contribute to better define its potential for macrophage-associated diseases, in general...
- A nanomedicine transports a peptide caspase-3 inhibitor across the blood-brain barrier and provides neuroprotectionHulya Karatas
Department of Neurology, Faculty of Medicine and Institute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey
J Neurosci 29:13761-9. 2009..Thus, chitosan nanospheres open new and exciting opportunities for brain delivery of biologically active peptides that are useful for the treatment of CNS disorders...
- Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cellsN P Dantuma
Microbiology and Tumor Biology Center, Karolinska Institutet, S 171 77 Stockholm Sweden
Nat Biotechnol 18:538-43. 2000..These reporters provide a new powerful tool for elucidation of the ubiquitin/proteasome pathway and for high throughput screening of compounds that selectively modify proteolysis in vivo...
- Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alphaThilo Hagen
Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
Science 302:1975-8. 2003..Thus, the signaling consequences of hypoxia may be profoundly modified by nitric oxide...
- Both Rb and E7 are regulated by the ubiquitin proteasome pathway in HPV-containing cervical tumor cellsJ Wang
Center for Molecular Biology of Oral Diseases, College of Dentistry (M/C 860, University of Illinois at Chicago, 60612, USA
Oncogene 20:4740-9. 2001..Taken together, this study suggests that targeted inhibition of Rb proteolysis will be required for restoring Rb function in HPV-containing cervical cancer cells...
- Caspase-dependent proteolysis of integral and peripheral proteins of nuclear membranes and nuclear pore complex proteins during apoptosisB Buendia
Département de Biologie Supramoléculaire et Cellulaire, Institut Jacques Monod, CNRS, Universite Paris 7, Tour 43, 75251 Paris Cedex 05, France
J Cell Sci 112:1743-53. 1999....
- The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSHYong Hwan Han
Department of Physiology, Medical School, Centers for Healthcare Technology Development, Institute for Medical Sciences Chonbuk National University, Jeonju, Korea
Oncol Rep 22:215-21. 2009..In conclusion, MG132 inhibited the growth of HeLa cells via inducing the cell cycle arrest as well as triggering apoptosis. The changes of ROS and GSH by MG132 were closely related to apoptosis in HeLa cells...
- Inhibition of autophagy induced by proteasome inhibition increases cell death in human SHG-44 glioma cellsPeng Fei Ge
1 Department of Neurosurgery, 1st Hospital of Jilin University, Changchun, Jilin 130021, China 2 Department of Neurosurgery, Xuanwu Hospital of Capital University of Medical Science, Beijing 100053, China
Acta Pharmacol Sin 30:1046-52. 2009..In this study, we sought to investigate whether inhibition of the proteasome can induce autophagy and the effects of autophagy on the fate of human SHG-44 glioma cells...
- Bax directly induces release of cytochrome c from isolated mitochondriaJ M Jurgensmeier
Program on Apoptosis and Cell Death Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 95:4997-5002. 1998....
- Cowpea bruchid Callosobruchus maculatus uses a three-component strategy to overcome a plant defensive cysteine protease inhibitorK Zhu-Salzman
Department of Entomology, Texas A and M University, College Station, TX 77843, USA
Insect Mol Biol 12:135-45. 2003..Our results suggest that the cowpea bruchid adapts to the challenge of scN by qualitative and quantitative remodelling of its digestive protease complement, and by activating scN-degrading protease activity...
- Salivary (SD-type) cystatins: over one billion years in the making--but to what purpose?D P Dickinson
Medical College of Georgia, School of Dentistry, Department of Oral Biology and Maxillofacial Pathology, 1120 15th Street, Augusta, GA 30912, USA
Crit Rev Oral Biol Med 13:485-508. 2002....
- The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin KJacques Yves Gauthier
Merck Frosst Centre for Therapeutic Research, 16711 Transcanada Hwy, Kirkland, Que, Canada
Bioorg Med Chem Lett 18:923-8. 2008..Evaluation in dermal fibroblast culture showed minimal intracellular collagen accumulation relative to less selective Cat K inhibitors...
- A novel inhibitor protein for Bombyx cysteine proteinase is homologous to propeptide regions of cysteine proteinasesY Yamamoto
Department of Biochemistry and Radiation Biology, College of Agriculture, Yamaguchi University, Japan
FEBS Lett 448:257-60. 1999..The results suggest that some cysteine proteinase proregions may have evolved as autonomous modules and become inhibitor proteins for cysteine proteinases...
- Mitochondrial release of caspase-2 and -9 during the apoptotic processS A Susin
Centre National de la Recherche Scientifique, UPR 420, F 94801 Villejuif, France
J Exp Med 189:381-94. 1999....
- Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family proteaseT W Kim
Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Science 277:373-6. 1997....
- Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasionKailash C Pandey
Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA
PLoS Pathog 2:e117. 2006..This mechanism of regulation of proteolysis suggests new strategies for the development of antimalarial agents that specifically disrupt erythrocyte invasion...
- Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruziA C Monteiro
, Bloco G, CCS, Universidade Federal do Rio de Janeiro, , Rio de Janeiro, CEP 21990-400, Brazil
J Cell Sci 114:3933-42. 2001..The intersection of chagasin and cruzipain trafficking pathways may represent a checkpoint for downstream regulation of proteolysis in trypanosomatid protozoa...
- Degradation of unassembled soluble Ig subunits by cytosolic proteasomes: evidence that retrotranslocation and degradation are coupled eventsR Mancini
Department of Molecular Pathology and Medicine, DIBIT San Raffaele Scientific Institute, 20132 Milan, Italy
FASEB J 14:769-78. 2000..Taken together, these results suggest that active proteasomes are required for the extraction of Ig subunits from the ER, though the requirements for retrotranslocation may differ among individual substrates...
- Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's diseaseAnthony C Vernon
Department of Neuroscience, Kings College London, The James Black Centre, UK
BMC Neurosci 11:1. 2010..Therefore, in this study we have utilised MRI to scan in vivo brains from rodents bearing a nigrostriatal lesion induced by intranigral injection of the proteasome inhibitor lactacystin...
- Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review)J Kos
Jozef Stefan Institute, Department of Biochemistry and Molecular Biology, 1000 Ljubljana, Slovenia
Oncol Rep 5:1349-61. 1998..Their application for diagnosis, follow-up and the anticancer therapy has also been proposed...
- Transfection of mGSTA4 in HL-60 cells protects against 4-hydroxynonenal-induced apoptosis by inhibiting JNK-mediated signalingJ Z Cheng
Department of Human Biological Chemistry and Genetics, UTMB, Galveston, Texas 77555-1067, USA
Arch Biochem Biophys 392:197-207. 2001..These results show that 4-HNE mediates apoptosis through its effects on JNK and caspase 3, and that 4-HNE metabolizing GST isozyme(s) may be important in the regulation of this pathway of oxidative-stress-induced apoptosis...
- Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patientsAleksandar Rakovic
Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Lubeck, 23562 Lübeck, Germany
Hum Mol Genet 19:3124-37. 2010....
- Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic modelSamuel G Melendez-Lopez
Department of Pathology, University of California, San Diego, San Diego, California 92103 8416, USA
Eukaryot Cell 6:1130-6. 2007..role of secreted cysteine proteinases in amebic invasion, we tested the effect of the vinyl sulfone cysteine proteinase inhibitors K11777 and WRR483 on invasion of human colonic xenografts...
- Role of cysteine proteinase inhibitors in preference of Japanese beetles (Popillia japonica) for soybean (Glycine max) leaves of different ages and grown under elevated CO2Jorge A Zavala
Institute for Genomic Biology, University of Illinois, Urbana Champaign, IL, USA
Oecologia 161:35-41. 2009..hormones jasmonic acid and ethylene; these in turn decrease the gene expression and activity of cysteine proteinase inhibitors (CystPIs), the principal antiherbivore defenses in foliage...
- Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemiaXiaoping Li
Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
Cardiovasc Res 83:72-9. 2009..The present study was to investigate the roles of calpain/calpastatin system in cardiomyocyte caspase-3 activation, TNF-alpha expression, and myocardial dysfunction during LPS stimulation...
- Characterization of Solanum tuberosum multicystatin and its structural comparison with other cystatinsMark S Nissen
School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4660, USA
Plant Cell 21:861-75. 2009..The unique molecular properties of the oligomeric PMC crystal are discussed in relation to its potential function in regulating the activity of proteases in potato tubers...
- Immunomodulatory properties of cystatinsB Vray
Laboratoire d Immunologie Expérimentale, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium
Cell Mol Life Sci 59:1503-12. 2002..On the whole, cystatins and cystatin-like molecules belong to a new category of immunomodulatory molecules. Doubtless increasing data will improve our knowledge of this property, leading to practical applications in immunotherapy...
- Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosisD W Nicholson
Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
Nature 376:37-43. 1995..A potent peptide aldehyde inhibitor has been developed and shown to prevent apoptotic events in vitro, suggesting that apopain/CPP32 is important for the initiation of apoptotic cell death...
- Regulation of p53 stability by Mdm2M H Kubbutat
ABL Basic Research Program, NCI FCRDC, Frederick, Maryland 21702 1201, USA
Nature 387:299-303. 1997..Furthermore, mechanisms regulating the Mdm2-induced degradation of p53 may play a role in controlling the extent and duration of the p53 response...
- Cystatin CDavid J Newman
South West Thames Institute for Renal Research, St Helier Hospital, Carshalton, Surrey, UK
Ann Clin Biochem 39:89-104. 2002....
- Conversion of Bcl-2 to a Bax-like death effector by caspasesE H Cheng
Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD 21205, USA
Science 278:1966-8. 1997..Cleavage-resistant mutants of Bcl-2 had increased protection from interleukin-3 withdrawal and Sindbis virus-induced apoptosis. Thus, cleavage of Bcl-2 by caspases may ensure the inevitability of cell death...
- Survivin expression in human osteosarcoma is a marker for survivalK Trieb
Department of Orthopedics, University of Colorado Health Sciences Center, Denver
Eur J Surg Oncol 29:379-82. 2003..Survivin is a member of the inhibitor of apoptosis (IAP) protein gene family and is expressed both during normal fetal development and in human cancer...
- Prevention of lymphocyte cell death in sepsis improves survival in miceR S Hotchkiss
Department of Anesthesiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 96:14541-6. 1999..Caspase inhibitors may represent a treatment strategy in this highly lethal disorder...
- The cysteine protease activity of Colorado potato beetle (Leptinotarsa decemlineata Say) guts, which is insensitive to potato protease inhibitors, is inhibited by thyroglobulin type-1 domain inhibitorsK Gruden
Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia
Insect Biochem Mol Biol 28:549-60. 1998..This demonstrated the potential of equistatin to protect crops from insect attack...
- C-Terminal extension of a plant cysteine protease modulates proteolytic activity through a partial inhibitory mechanismSruti Dutta
Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Kolkata, India
FEBS J 278:3012-24. 2011..These data suggest that the CT-extension has an inhibitory role in the proteolytic activity of ervatamin-C but does not have a major role either in stabilizing the enzyme or in its folding mechanism...
- Tigutcystatin, a cysteine protease inhibitor from Triatoma infestans midgut expressed in response to Trypanosoma cruziDiego S Buarque
Department of Biochemistry, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, 04044 020 Sao Paulo, SP, Brazil
Biochem Biophys Res Commun 413:241-7. 2011..cruzi. Together, these results indicate that Tigutcystatin may be involved in modulation of T. cruzi in intestinal tract by inhibiting parasite cysteine proteases, which represent the virulence factors of this protozoan...
- α-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPBKoen Steert
Department of Medicinal Chemistry, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
ChemMedChem 5:1734-48. 2010..8; however, in vitro whole-organism screening against a panel of protozoan parasites did not fully correlate with the observed inhibition of the cysteine protease...
- The role of cysteine proteinases and their inhibitors in the host-pathogen cross talkNatasa Kopitar-Jerala
Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
Curr Protein Pept Sci 13:767-75. 2012..In this review, I provide an update on the most recent developments regarding the role of proteinases and their inhibitors in the initiation and regulation of immune responses...
- The specificity of trichomonad cysteine proteinases analysed using fluorogenic substrates and specific inhibitorsM J North
Department of Biological and Molecular Sciences, School of Natural Sciences, University of Stirling, U K
Mol Biochem Parasitol 39:183-93. 1990..vaginalis and T. foetus. The information on the specificities will be useful for assessing the features required in proteinase inhibitors if they are to be of potential value as antitrichomonal agents...
- Proteolysis of human monocyte CD14 by cysteine proteinases (gingipains) from Porphyromonas gingivalis leading to lipopolysaccharide hyporesponsivenessS Sugawara
Department of Microbiology and Immunology, Tohoku University School of Dentistry, Sendai, Japan
J Immunol 165:411-8. 2000..These results suggest that gingipains preferentially cleave monocyte CD14, resulting in attenuation of the cellular recognition of bacteria, and as a consequence sustain chronic inflammation...
- Expression of survivin correlated with vessel invasion is a marker of poor prognosis in small adenocarcinoma of the lungMizuki Ikehara
Department of Thoracic Oncology, Kanagawa Cancer Center, Asahi ku, Yokohama 241 0815, Japan
Oncol Rep 9:835-8. 2002..014; Wilcoxon test, p=0.021). It can be concluded that the expression of survivin in tumor cells is a factor of poor prognosis in patients with small adenocarcinoma of the lung...
- Orally bioavailable cathepsin K inhibitors with pyrrolopyrimidine scaffoldNaoki Teno
Novartis Institutes for BioMedical Research, Tsukuba, Ibaraki, Japan
Curr Top Med Chem 10:752-66. 2010..This article constitutes a near comprehensive review of the published scientific literature on small molecule non-peptidic inhibitors for cathepsin K developed by Novartis...
- Phylogenomic analysis of the cystatin superfamily in eukaryotes and prokaryotesDusan Kordis
Department of Biochemistry and Molecular and Structural Biology, J, Stefan Institute, Ljubljana, Slovenia
BMC Evol Biol 9:266. 2009..Our aim has been to obtain a comprehensive insight into their origin, distribution, diversity, evolution and classification in Eukaryota, Bacteria and Archaea...
- PROTEASE INHIBITORS--NOVEL DRUG THERAPY FOR T GONDIISharon Reed; Fiscal Year: 2001..of cystine proteinases and their role in peptide degradation and evaluating the effect of specific cysteine proteinase inhibitors on parasite survival and identify their site of action...
- CYSTATIN C EFFECT ON B16 MELANOMA METASTASISJames Cox; Fiscal Year: 2001..The overall goal of this project is to elucidate steps by which natural cysteine proteinase inhibitors, the cystatins, may act as antimetastatic agents...
- DESIGN AND SYNTHESIS OF CYSTEINE PROTEINASE INHIBITORSDANIEL RICH; Fiscal Year: 1992..Develop a 3- dimensional model for the human cysteine proteinases, cathepsin B, H, and L, for which X-ray crystal structures are not available...
- REGULATION OF INDUCIBLE RAT SALIVARY CYSTATINGurrinder Bedi; Fiscal Year: 1990b>Cysteine proteinase inhibitors of the cystatin superfamily are grouped into three families on the basis of their molecular structure...
- PROTEASE INHIBITORS IN HUMAN BLADDER CANCER INVASIONBrian Liu; Fiscal Year: 1993..In this proposal, we will determine the effects of cysteine proteinase inhibitors in inhibiting the activity of plasma membrane bound cathepsin B at a biochemical level using enzyme ..
- MOLECULAR ANALYSIS OF HUMAN SALIVARY CYSTATIN GENESDouglas Dickinson; Fiscal Year: 1991..The type 2 cystatins are a group of cysteine proteinase inhibitors that are major protein constituents of saliva...
- CHARACTERIZATION OF TUMOR CYSTEINE INHIBITORSBonnie Sloane; Fiscal Year: 1992..is to determine the role(s) of cysteine proteinases (in particular cathepsin B) and endogenous low Mr cysteine proteinase inhibitors (CPI) in tumor cell metastasis. Increases activities of several cysteine proteinases, e.g...
- Host Protein Degradation by Schistosome ParasitesJames McKerrow; Fiscal Year: 2007..abstract_text> ..
- Targeting Cysteine Proteases: Antiparasitic ChemotherapyJames McKerrow; Fiscal Year: 2008..No Abstract Provided. ..
- Clinical & Molecular Studies of Drug Resistant MalariaPhilip Rosenthal; Fiscal Year: 2008..abstract_text> ..
- Water-Soluble and Metabolically Stable Calpain Inhibitors as CardioprotectantsISAAC DONKOR; Fiscal Year: 2008..Furthermore, the proposed studies will provide mechanistic insight into the mode of action of calpain inhibitors as cardioprotectants. ..
- High Throughput Assay for Screening Compounds(RMI)James McKerrow; Fiscal Year: 2005..Computational and informatics capability is in place to acquire, store and cross-reference this data, and provide access to the scientific community through an open-source website. ..
- Chemoprevention Potential of Calpain InhibitorsISAAC DONKOR; Fiscal Year: 2007..The proposal is significant and innovative because it seeks to investigate calpain as a pharmacological target for the discovery of a new class of chemoprevention agents. [unreadable] [unreadable] [unreadable]..
- Targeting Calpain for Novel Anticancer AgentsISAAC DONKOR; Fiscal Year: 2005..Additionally, the compounds are useful biomedical tools for investigating the intracellular roles of Calpain due to their metabolic stability. The compounds are also potential anticancer agents. ..
- Falcipain Cysteine Proteases of Malaria ParasitesPhilip Rosenthal; Fiscal Year: 2005..Experiments designed to accomplish these aims should improve our understanding of the biology of malaria parasites and aid in the characterization of falcipains as potential drug targets. ..
- Resistance of Malaria Parasites to Artemisinin-Based Combination TherapiesPhilip Rosenthal; Fiscal Year: 2008..abstract_text> ..
- ROLE OF PROTEASOMAL DYSFUNCTION IN PARKINSON'S DISEASEKEVIN MCNAUGHT; Fiscal Year: 2008..These studies will test our hypothesis that inadequate proteasomal function underlies both vulnerability and degeneration of the SNc in sporadic Parkinson's disease. ..
- PROBING THE S' SUBSITES OF CALPAINISAAC DONKOR; Fiscal Year: 2002..Selected potent and cell permeable inhibitors will be tested in the rat isolated heart ischemia model for cardioprotective effect. ..
- EVALUATION OF FALCIPAIN AS AN ANTIMALARIAL DRUG TARGETPhilip Rosenthal; Fiscal Year: 2003..This evaluation is also likely to identify specific falcipain inhibitors with potent antimalarial activity that will be ready for initial testing against human malaria. ..
- IMPACT OF AH RECEPTOR DEGRADATION IN VIVO AND IN VITRORICHARD POLLENZ; Fiscal Year: 2005..abstract_text> ..
- Serpin Protease Inhibitors & Opioid NeuropeptidesVivian Hook; Fiscal Year: 2006..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..
- Beta-Secretase Assays to Discover Drugs for Alzheimer'sGregory Hook; Fiscal Year: 2004..ActiveSite Biotech is in a position to exclusively sell, license, or partner lead drug inhibitors resulting from the Phase II study. ..
- BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDESVivian Hook; Fiscal Year: 2009..These findings will enhance our knowledge of the complexity of the endogenous opioid system. ..
- Proteomics/Genomics of Opiate Analgesia and AddictionVivian Hook; Fiscal Year: 2004..Elucidation of distinct pathways will be significant, since it could allow future design of opiate drug regimens that provide effective analgesia, without the tolerance and dependence of addiction. ..
- Inhibitors of beta-Amyloid Production in Alzheimer'sGregory Hook; Fiscal Year: 2007..Specifically, we will assess the affects of these peptidomimetics on beta-amyloid secretion in primary neuronal cultures and in vivo. ..
- POMC Processing and Beta-Endorphine-Related Opioid PeptidesVivian Y H Hook; Fiscal Year: 2010..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
- Gamma Secretase Assays to Discover Drugs for Alzheimer'sGregory Hook; Fiscal Year: 2006..Results will likely identify novel lead compounds for future pre-clinical animal studies for development of effective drugs for AD. ..
- INTEGRATED DNA SEQUENCING SYSTEMVivian Hook; Fiscal Year: 2002..abstract_text> ..
- SCREENS TO IDENTIFY GAIN OF FUNCTION AH RECEPTOR MUTANTS INVOLVED IN DEGRADATIONRICHARD POLLENZ; Fiscal Year: 2008..e. steroid hormone receptors). [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- The Role of MicroRNA in HepatocarcinogenesisKalpana Ghoshal; Fiscal Year: 2007..Further, this proposal fits well with the mission/goals set forth by multiple institutes that include NCI, NIDDK and NIAAA n the etiology, prevention and treatment of hepatocellular carcinomas. [unreadable] [unreadable] [unreadable]..
- Proteasome function in the aging retinaDeborah A Ferrington; Fiscal Year: 2010..Results from these experiments will help verify that immunoproteasome is an essential component of the retinal stress response and plays a fundamental role in maintaining retinal health. ..
- Safety of Lung Delivered Tissue Plasminogen ActivatorKATHLEEN STRINGER; Fiscal Year: 2006..The proposed Phase II project will complement and extend our Phase I work and will facilitate the development of a promising new, greatly needed therapeutic for the treatment of ARDS. ..
- High Resolution Hybrid FT-ICR Mass SpectrometerJoseph Loo; Fiscal Year: 2006..The instrument will be a centerpiece and will be supported and administered by the newly-created Molecular Instrumentation Center at UCLA, and it will serve researchers from across the institution. [unreadable] [unreadable] [unreadable]..
- DYSKINESIAS IN LENTI-GDNF TREATED PARKINSONIAN MONKEYSJeffrey Kordower; Fiscal Year: 2006..This application will determine whether potent dopaminergic gene therapies influence dyskinesias in the best animal model of PD. ..
- CELL PATHOLOGY IN KIDNEY HYPOXIA. ROLE OF BAXPothana Saikumar; Fiscal Year: 2007..In vivo gene silencing of Bax will be attempted in efforts to block up regulation of Bax and thereby prevent cell injury in the ischemic kidney. ..
- Role of Survivin in Blood Stem Cell Cycle and ApoptosisLOUIS PELUS; Fiscal Year: 2007....
- Macromolecular Therapy for Improved Treatment of Rheumatoid ArthritisDong Wang; Fiscal Year: 2009..Eventually, this novel delivery system would lead to improved efficacy and safety profiles for treatment of rheumatoid arthritis and other inflammatory joint disorders. ..
- Reconstitution of Protective CMV Immunity and Immune Regulation After HAARTAdriana Weinberg; Fiscal Year: 2008..These analyses will define the role of TREG in the inadequate CMV immune reconstitution of HAART recipients. [unreadable] [unreadable] [unreadable] [unreadable]..
- Structural examination of serpin-protein interactionsPETER GETTINS; Fiscal Year: 2009..Dudley Strickland. ..
- Center for Nutrient-Gene Interaction in Cancer Preventi*Stephen Barnes; Fiscal Year: 2008..In addition to the main projects, the Center will organize a competitive Pilot Project/Developmental program for the evaluation of new ideas and methods pertinent to the overall development of the Center. ..
- TH and GTPCHI gene therapy for Parkinson's diseaseJeffrey H Kordower; Fiscal Year: 2010..These studies will determine the safety and efficacy of gene delivery of LDOPA and determine whether this approach is appropriate for clinical trials. ..
- MAPK/PKR Modulation of Diaphragm WeaknessGerald S Supinski; Fiscal Year: 2010..We will both characterize the effects of inflammation on DISC formation, localization, and autocatalytic activity and determine if these alterations can be blocked by inhibition of p38, JNK, and/or PKR signaling pathways. ..
- Hollings Cancer Center Planning GrantAndrew Kraft; Fiscal Year: 2005..abstract_text> ..
- LENTIVIRAL GENE TRANSFER INTO PANCREATIC BETA-CELLSMark Segal; Fiscal Year: 2003....
- Sex in Viral MyocarditisSally Huber; Fiscal Year: 2004..These studies may provide new insights as to how viruses affect developing host defense responses and how hormones can modulate this initial response. ..
- Conference on Photodynamic TherapyDavid Kessel; Fiscal Year: 2002..The most recent PDT meeting, sponsored by the International Photodynamic Assn, has more than 600 participants. ..
- TISSUE TRANSGLUTAMINASE: A ROLE IN HUNTINGTON'S DISEASEMathieu Lesort; Fiscal Year: 2004....
- Cathepsin B in Progression of Prostatic Lesion to CancerAKHOURI SINHA; Fiscal Year: 2004....
- MUTUAL REGULATION OF P53, MDM2 AND NFKB:Muxiang Zhou; Fiscal Year: 2004....
- VISUAL CYCLE PROTEINSJohn Crabb; Fiscal Year: 2002..The proposed studies will lead to a better understanding of the structure, function and regulation of CRALBP and the visual disorders with which at may be associated. ..
- Novel Signaling Targets in GI Neuroendocrine TumorsHerbert Chen; Fiscal Year: 2005..The possibility that raf-l-mediated hormone suppression could be induced by a soluble factor would provide a plausible, therapeutic delivery method. ..
- MOLECULAR INTERACTIONS OF FIBRINOLYSISJohn Anagli; Fiscal Year: 2005..This project can provide a foundation at the molecular level for rational development of therapeutic agents to modulate PAI-1 activity. ..
- Suppression of Breakthrough Bleeding in LNG-IUS UsersOv Slayden; Fiscal Year: 2006..The proposal brings basic scientists and clinicians together for a "bench to bedside" approach that will advance women's health and improve contraceptive technology. ..
- Retinal Cell Death in Diabetic RetinopathySusanne Mohr; Fiscal Year: 2006..abstract_text> ..
- Calcium-activated protease in cataract formationThomas Shearer; Fiscal Year: 2006..unreadable] [unreadable] 3. Define the roles of calpain 10 in human lens. [unreadable] [unreadable] These studies will provide a rational basis for the use of protease inhibitors to prevent cataracts. ..
- CONNEXIN32 MUTATIONS IN CHARCOT-MARIE-TOOTH-X DISEASELINDA MUSIL; Fiscal Year: 2004..These studies will elucidate the causes of phenotypic diversity in CMTX as well as provide the first molecular insights into the quality control mechanisms that govern the fidelity of connexin assembly into gap junctional channels. ..
- Tenth International Congress on Ceroid LipofuscinosesGlyn Dawson; Fiscal Year: 2005....
- 9.4 Tesla Fourier Transform Mass SpectrometerStephen Barnes; Fiscal Year: 2002..Overall, the FT-MS instrument will sustain the high quality of biomedical research that is a hallmark of UAB. ..
- CDI and Gamma Delta+ in Viral MyocarditisSally Huber; Fiscal Year: 2005..abstract_text> ..
- INVESTIGATING THE MECHANISMS OF PRB TUMOR SUPPRESSIONArnab Chakravarti; Fiscal Year: 2003..Specific Aim number 3: To determine whether the deregulation of E2F dependent transcription is correlated with the tumorigenic potential of RB -/- cells in-vivo. ..
- 25-hydroxy-D3 as a possible chemopreventive agent for breast cancerXinjian Peng; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- MINORITY PREDOCTORAL FELLOWSHIP PROGRAMMelanie Mediavilla Varela; Fiscal Year: 2008..These studies will provide insights into the mechanisms underlying prostate tumor resistance to cell death and lead to development of novel therapeutic strategies for PCa. [unreadable] [unreadable] [unreadable]..
- Caspase Mediated Diaphragmatic DysfunctionGERALD SUPINSKI; Fiscal Year: 2009..These experiments will use both transgenic animal models and C2C12 cells to assess the effect of genetic and chemical inhibition of superoxide/nitric oxide on caspase responses. ..
- Divalent Metal Transporter: Role in Manganese ToxicityJEROME ROTH; Fiscal Year: 2004....
- Anti-Leukemic Activity of the Novel Triterpeniod CDDOMichael Andreeff; Fiscal Year: 2004..The long-term goal of our proposed mechanistic and efficacy studies is to determine the potential of CDDO as a novel anti-leukemia and anti-tumor agent. ..
- DIAPHRAGMATIC DYSFUNCTION IN SEPSISGERALD SUPINSKI; Fiscal Year: 2001..These data suggest that the proposed experiments should provide important information regarding the pathogenesis of sepsis-induced muscle dysfunction. ..
- A sensitive triple quadrupole mass spectrometerStephen Barnes; Fiscal Year: 2004..It is anticipated that a commercial nanospray interface for use in nanoLC-MS analysis will be available by the fall of 2003. ..
- GLUTATHIONE TRANSFERASES AND OXIDATIVE STRESS TOXICOLOGYPiotr Zimniak; Fiscal Year: 2005..The proposed work is intended to advance the understanding of the physiological and toxicological consequences of oxidative stress, as mediated by 4-HNE. ..
- MECHANISMS OF TRANSFORMATION OF HEMATOPOIETIC CELLSJAMES MC CUBREY; Fiscal Year: 2001..An understanding of how these signal transduction and apoptotic pathways impinge upon one another will further our comprehension of the consequences of abnormal oncogene activation and tumor progression. ..