free radical scavengers

Summary

Summary: Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.

Top Publications

  1. ncbi Phenyl N-tert-butylnitrone, a free radical scavenger, reduces mechanical allodynia in chemotherapy-induced neuropathic pain in rats
    Hee Kee Kim
    Department of Anesthesiology, Perioperative Medicine, and Pain Management, University of Miami, LM Miller School of Medicine, 1011 Northwest 15th Street, Miami, Florida 33136, USA
    Anesthesiology 112:432-9. 2010
  2. ncbi Neuroprotective effects of resveratrol on cerebral ischemia-induced neuron loss mediated by free radical scavenging and cerebral blood flow elevation
    Kwok Tung Lu
    Department of Life Science, National Taiwan Normal University, Taipei, Taiwan
    J Agric Food Chem 54:3126-31. 2006
  3. ncbi Polyphenols enhance total oxidant-scavenging capacities of human blood by binding to red blood cells
    Erez Koren
    Department of Pharmaceutics, School of Pharmacy, Hadassah Faculty of Medicine, Hebrew University, Ein Kerem Campus, Jerusalem 91120, Israel
    Exp Biol Med (Maywood) 235:689-99. 2010
  4. ncbi Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers
    T C Dinis
    Laboratorio de Bioquimica, Faculdade de Farmacia, Universidade de Coimbra, Portugal
    Arch Biochem Biophys 315:161-9. 1994
  5. ncbi Antioxidant activity of food constituents: an overview
    Ilhami Gulcin
    Department of Chemistry, Ataturk University, 25240 Erzurum, Turkey
    Arch Toxicol 86:345-91. 2012
  6. ncbi Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant
    Sabine Heumüller
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Hypertension 51:211-7. 2008
  7. ncbi Free radical scavenging properties of wheat extracts
    Liangli Yu
    Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, Colorado 80523, USA
    J Agric Food Chem 50:1619-24. 2002
  8. ncbi Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2, Ohno Higashi, Osakasayama, Osaka 589 8511, Japan
    Neurochem Res 35:348-55. 2010
  9. ncbi Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain
    Ning Zhang
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo 113 0033, Japan
    Stroke 36:2220-5. 2005
  10. ncbi Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke
    Mushfiquddin Khan
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci Res 76:519-27. 2004

Detail Information

Publications328 found, 100 shown here

  1. ncbi Phenyl N-tert-butylnitrone, a free radical scavenger, reduces mechanical allodynia in chemotherapy-induced neuropathic pain in rats
    Hee Kee Kim
    Department of Anesthesiology, Perioperative Medicine, and Pain Management, University of Miami, LM Miller School of Medicine, 1011 Northwest 15th Street, Miami, Florida 33136, USA
    Anesthesiology 112:432-9. 2010
    ..Free radicals have been implicated in many neurodegenerative diseases. The current study tests the hypothesis that a free radical scavenger plays an important role in reducing chemotherapy-induced neuropathic pain...
  2. ncbi Neuroprotective effects of resveratrol on cerebral ischemia-induced neuron loss mediated by free radical scavenging and cerebral blood flow elevation
    Kwok Tung Lu
    Department of Life Science, National Taiwan Normal University, Taipei, Taiwan
    J Agric Food Chem 54:3126-31. 2006
    ..The results demonstrated that a single infusion of resveratrol could elicit neuroprotective effects on cerebral ischemia-induced neuron damage through free radical scavenging and cerebral blood elevation due to NO release...
  3. ncbi Polyphenols enhance total oxidant-scavenging capacities of human blood by binding to red blood cells
    Erez Koren
    Department of Pharmaceutics, School of Pharmacy, Hadassah Faculty of Medicine, Hebrew University, Ein Kerem Campus, Jerusalem 91120, Israel
    Exp Biol Med (Maywood) 235:689-99. 2010
    ..Further studies are needed to determine the faith of polyphenols in the circulation and their sequestration in the spleen...
  4. ncbi Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers
    T C Dinis
    Laboratorio de Bioquimica, Faculdade de Farmacia, Universidade de Coimbra, Portugal
    Arch Biochem Biophys 315:161-9. 1994
    ..Such a stabilization is not possible with salicylate and is decreased in acetaminophen by an electron withdrawing effect of the p-acetyl...
  5. ncbi Antioxidant activity of food constituents: an overview
    Ilhami Gulcin
    Department of Chemistry, Ataturk University, 25240 Erzurum, Turkey
    Arch Toxicol 86:345-91. 2012
    ..In addition, there are given some chemical and kinetic basis and technical details of the used methods...
  6. ncbi Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant
    Sabine Heumüller
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Hypertension 51:211-7. 2008
    ..These observations indicate that apocynin predominantly acts as an antioxidant in endothelial cells and vascular smooth muscle cells and should not be used as an NADPH oxidase inhibitor in vascular systems...
  7. ncbi Free radical scavenging properties of wheat extracts
    Liangli Yu
    Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, Colorado 80523, USA
    J Agric Food Chem 50:1619-24. 2002
    ..The TPC were 487.9 +/- 927.8 microg gallic acid equivalents/g of grain. No correlation was observed between TPC and radical scavenging capacities for DPPH* and ABTS*+ (p = 0.15 and p > 0.5, respectively)...
  8. ncbi Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2, Ohno Higashi, Osakasayama, Osaka 589 8511, Japan
    Neurochem Res 35:348-55. 2010
    ..In summary, edaravone treatment improved cerebral dysfunction following TBI, suggesting its potential as an effective clinical therapy...
  9. ncbi Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain
    Ning Zhang
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo 113 0033, Japan
    Stroke 36:2220-5. 2005
    ....
  10. ncbi Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke
    Mushfiquddin Khan
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci Res 76:519-27. 2004
    ..These results indicate that in a rat model of experimental stroke, administration of NAC even after ischemia onset protected the brain from free radical injury, apoptosis, and inflammation, with a wide treatment window...
  11. ncbi N-acetylcysteine versus AScorbic acid for preventing contrast-Induced nephropathy in patients with renal insufficiency undergoing coronary angiography NASPI study-a prospective randomized controlled trial
    Sang Ho Jo
    Department of Internal Medicine, Seoul National University College of Medicine Cardiovascular Center, Seoul National University Hospital, Korea
    Am Heart J 157:576-83. 2009
    ..There has been no study comparing the efficacy of N-acetylcysteine (NAC) and ascorbic acid that have potential for CIN prevention in patients with renal insufficiency...
  12. ncbi Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo
    Yuta Inokuchi
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
    J Pharmacol Exp Ther 329:687-98. 2009
    ..These findings suggest that oxidative stress plays a pivotal role in retinal damage and that edaravone may be a candidate for the effective treatment of retinal diseases...
  13. ncbi Administration of edaravone, a free radical scavenger, during t-PA infusion can enhance early recanalization in acute stroke patients--a preliminary study
    Kazumi Kimura
    Department of Stroke Medicine, Kawasaki Medical School, Japan
    J Neurol Sci 313:132-6. 2012
    ..The aim of the present study was to investigate whether administration of edaravone during t-PA infusion can enhance early recanalization in acute stroke patients...
  14. ncbi Cytotoxic and antioxidant triterpene saponins from Butyrospermum parkii (Sapotaceae)
    Leon A Tapondjou
    Department of Chemistry, Faculty of Science, University of Dschang, Box 183, Dschang, Cameroon
    Carbohydr Res 346:2699-704. 2011
    ....
  15. pmc Antioxidant and free radical scavenging activity of Spondias pinnata
    Bibhabasu Hazra
    Division of Molecular Medicine, Bose Institute, P 1 12 CIT Scheme VIIM, Kolkata 700054, India
    BMC Complement Altern Med 8:63. 2008
    ..Current research is directed towards finding naturally-occurring antioxidants of plant origin. The aim of the present study was to evaluate the in vitro antioxidant activities of Spondias pinnata stem bark extract...
  16. ncbi Erythritol is a sweet antioxidant
    Gertjan J M den Hartog
    Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    Nutrition 26:449-58. 2010
    ..g., by the diet. Erythritol, a simple polyol, could be such a compound. It is orally available, well tolerated, and its chemical structure resembles that of mannitol, a well-known hydroxyl radical (HO*) scavenger...
  17. pmc Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats
    Guo hua Wang
    Department of Neuropharmacology, Institute of Nautical Medicine, Nantong University, Nantong, Jiangsu, China
    J Neurotrauma 28:2123-34. 2011
    ..The likely mechanism is via inhibiting oxidative stress, leading to a decreased inflammatory response and glial activation, and thereby reducing neuronal death and improving neurological function...
  18. ncbi Microbial and host cells acquire enhanced oxidant-scavenging abilities by binding polyphenols
    Isaac Ginsburg
    The Faculty of Dental Medicine, Institute for Dental Sciences, Hebrew University, Hadassah Medical Center, P O Box 12065, Jerusalem 91120, Israel
    Arch Biochem Biophys 506:12-23. 2011
    ..In addition to their antioxidant and metal chelating properties, polyphenols may also act as signaling agents capable of affecting metabolic, inflammatory, autoimmune, carcinogenic and aging processes...
  19. ncbi Cisplatin-evoked DNA fragmentation in normal and cancer cells and its modulation by free radical scavengers and the tyrosine kinase inhibitor STI571
    Katarzyna Wozniak
    Department of Molecular Genetics, University of Lodz, Banacha 12 16, 90 237 Lodz, Poland
    Chem Biol Interact 147:309-18. 2004
    ....
  20. ncbi Beyond neurological disease: new targets for edaravone (Review)
    Kiyoshi Kikuchi
    Department of Neurosurgery, Yame Public General Hospital, Yame 834 0034, Japan
    Int J Mol Med 28:899-906. 2011
    ....
  21. pmc Antioxidant activities and phenolic contents of the methanol extracts of the stems of Acokanthera oppositifolia and Adenia gummifera
    Adeolu A Adedapo
    Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Ibadan, Nigeria
    BMC Complement Altern Med 8:54. 2008
    ..Antioxidants thus play an important role of protecting the human body against damage by the free radicals. Plants containing phenolic compounds have been reported to possess strong antioxidant properties...
  22. ncbi Effect of a free radical scavenger, edaravone, in the treatment of patients with aneurysmal subarachnoid hemorrhage
    Akira Munakata
    Department of Neurosurgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Neurosurgery 64:423-8; discussion 428-9. 2009
    ..This study therefore investigated the effect of a new free radical scavenger, edaravone, in the treatment of patients with aneurysmal SAH...
  23. ncbi Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and anti-inflammatory properties
    A Reum Kim
    Division of Food Science and Biotechnology, Pukyong National University, Busan 608 737
    J Agric Food Chem 57:3483-9. 2009
    ..In conclusion, these results suggest that phlorofucofuroeckol A has a potential for functional foods with antioxidant and anti-inflammatory activities...
  24. ncbi Phase II, randomized, controlled trial of high-dose N-acetylcysteine in high-risk cardiac surgery patients
    Michael Haase
    Department of Intensive Care, Austin Hospital, University of Melbourne, Australia
    Crit Care Med 35:1324-31. 2007
    ..To assess the effect of high-dose N-acetylcysteine on renal function in cardiac surgery patients at higher risk of postoperative renal failure...
  25. ncbi Antioxidant property of an ethanol extract of the stem of Opuntia ficus-indica var. saboten
    Jeong Chae Lee
    Division of Biological Sciences and the Research Center for Bioactive Materials, Chonbuk National University, Chonju 561 756, Korea
    J Agric Food Chem 50:6490-6. 2002
    ..Finally, the OFS extract was characterized as containing a high amount of phenolics (180.3 mg/g), which might be the active compounds responsible for the antioxidant properties of the OFS extract...
  26. ncbi On-line HPLC-DPPH screening method for evaluation of radical scavenging phenols extracted from apples (Malus domestica L.)
    Donata Bandoniene
    Institute of Food Chemistry and Technology, Graz University of Technology, Petersgasse 12, A 8010 Graz, Austria
    J Agric Food Chem 50:2482-7. 2002
    ....
  27. ncbi Antioxidative activity and safety of the 50 ethanolic extract from red bean fermented by Bacillus subtilis IMR-NK1
    Yun Chin Chung
    Department of Food and Nutrition, Providence University, 200 Chungchi Road, Shalu, Taichung, 433 Taiwan, Republic of China
    J Agric Food Chem 50:2454-8. 2002
    ..No mutagenicity or toxicity effect toward all tester strains was found in the 50% ethanolic extract of fermented red bean by means of the Ames test. The results suggested that the 50% ethanolic extract was safe in genotoxicity...
  28. ncbi Edaravone mimics sphingosine-1-phosphate-induced endothelial barrier enhancement in human microvascular endothelial cells
    Kazuyoshi Omori
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Am J Physiol Cell Physiol 293:C1523-31. 2007
    ....
  29. ncbi Melatonin as a radioprotective agent: a review
    - Vijayalaxmi
    Department of Radiation Oncology, The University of Texas Health Science Center, San Antonio, 78229, USA
    Int J Radiat Oncol Biol Phys 59:639-53. 2004
    ..The potential use of melatonin for protecting individuals from radiation terrorism is also considered...
  30. ncbi In vitro antioxidant and free radical scavenging activity of Cyperus rotundus
    R Yazdanparast
    Institute of Biochemistry and Biophysics, The University of Tehran, Tehran, Iran
    J Med Food 10:667-74. 2007
    ..These results clearly established the antioxidative potency of C. rotundus, which may account for some of the medical claims attributed to this plant...
  31. ncbi A comparative study on phenolic profiles and antioxidant activities of legumes as affected by extraction solvents
    B J Xu
    Dept of Cereal and Food Sciences, North Dakota State Univ, Fargo, ND 58105, USA
    J Food Sci 72:S159-66. 2007
    ..High correlations between phenolic compositions and antioxidant activities of legume extracts were observed. The information is of interest to the nutraceutical food/ingredient industries since legumes are a rich source of antioxidants...
  32. ncbi Standard vs double dose of N-acetylcysteine to prevent contrast agent associated nephrotoxicity
    Carlo Briguori
    Laboratory of Interventional Cardiology, Vita e Salute University School of Medicine, University of Milan, Milan, Italy
    Eur Heart J 25:206-11. 2004
    ..We tested whether a double dose of NAC is more effective to prevent CAN...
  33. pmc Beneficial effects of n-acetylcysteine on ischaemic brain injury
    S Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C Valeria, Italy
    Br J Pharmacol 130:1219-26. 2000
    ..6. Histological observations of the pyramidal layer of CA1 showed a reduction of neuronal loss in animals that received NAC. 7. These results show that NAC improves brain injury induced by transient cerebral ischaemia...
  34. pmc Intracellular ROS protection efficiency and free radical-scavenging activity of curcumin
    Abolfazl Barzegar
    Research Institute for Fundamental Sciences RIFS, University of Tabriz, Tabriz, Iran
    PLoS ONE 6:e26012. 2011
    ..Therfore, since curcumin is inherently a lipophilic compound, because of its superb intracellular ROS scavenging activity, it can be used as an effective antioxidant for ROS protection within the polar cytoplasm...
  35. doi Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxides
    Junping Chen
    Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Nat Nanotechnol 1:142-50. 2006
    ..The use of nanoceria particles as a direct therapy for multiple diseases represents a novel strategy and suggests that they may represent a unique platform technology...
  36. ncbi Iron chelation improves endothelial function in patients with coronary artery disease
    S J Duffy
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    Circulation 103:2799-804. 2001
    ..These results suggest that iron availability contributes to impaired nitric oxide action in atherosclerosis...
  37. ncbi Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense
    Hyuncheol Oh
    Laboratory of Cell Signaling Regulation, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305 333, South Korea
    J Ethnopharmacol 95:421-4. 2004
    ..8 +/- 0.4 microM and 22.7 +/- 2.8 microM, respectively). These results support the use of this plant for the treatment of hepatitis in oriental traditional medicine...
  38. ncbi Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging
    J E Slemmer
    Department of Biology, University of Prince Edward Island, Charlottetown, PE, Canada
    Curr Med Chem 15:404-14. 2008
    ..In particular, we demonstrate how antioxidants derived from natural products, as well as long-term dietary alterations, may prove to be effective scavengers of ROS and RNS...
  39. ncbi Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage
    Perla D Maldonado
    Department of Biology, Universidad Nocional Autonoma de Mexico, Mexico D F, Mexico
    Free Radic Biol Med 35:317-24. 2003
    ..In conclusion, SAC ameliorates the GM-induced ARF by a mechanism related, at least in part, to its ability to decrease oxidative stress and to preserve antioxidant enzymes activity in renal cortex...
  40. ncbi X-ray crystal structure and antioxidant activity of salidroside, a phenylethanoid glycoside
    Peizhong Yu
    Department of Chemistry of Natural Drugs, School of Pharmacy, Fudan University, Shanghai 200032, PR China
    Chem Biodivers 4:508-13. 2007
    ..e., tyrosol (=4-(2-hydroxyethyl)phenol; 2)...
  41. ncbi Aged garlic extract attenuates gentamicin induced renal damage and oxidative stress in rats
    Perla D Maldonado
    Department of Biology, Faculty of Chemistry, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 D F, Mexico, Mexico
    Life Sci 73:2543-56. 2003
    ..These data suggest that AGE may be a useful agent for the prevention of GM-nephrotoxicity...
  42. ncbi Antioxidant activity of leaf extracts from Bauhinia monandra
    A C C Argolo
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Pernambuco, s n Cidade Universitária, Pernambuco, Brazil
    Bioresour Technol 95:229-33. 2004
    ..The results indicate that the extracts of B. monandra have a very potent antioxidant activity, compared with the pure catechins used as positive controls and with other plant extracts...
  43. ncbi Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective
    D Venkat Ratnam
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research NIPER, Phase X, S A S Nagar, Mohali, Punjab, India
    J Control Release 113:189-207. 2006
    ..Results from several studies conducted across the globe are positive and provided us with new anticipation for the improvement of human healthcare...
  44. ncbi Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica
    Jing Wang
    Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China
    Int J Biol Macromol 42:127-32. 2008
    ..Available data obtained with in vitro models suggested that the ratio of sulfate content/fucose was an effective indicator to antioxidant activity of the samples...
  45. ncbi Ferulic acid provides neuroprotection against oxidative stress-related apoptosis after cerebral ischemia/reperfusion injury by inhibiting ICAM-1 mRNA expression in rats
    Chin Yi Cheng
    Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan
    Brain Res 1209:136-50. 2008
    ....
  46. ncbi Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator
    Kenji Yagi
    Department of Neurosurgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Stroke 40:626-31. 2009
    ..Patients with acute infarct benefit from the neuroprotective drug edaravone, a free radical scavenger. We examined the mechanisms by which edaravone may help to suppress rtPA-induced brain hemorrhage...
  47. ncbi N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency
    Kondala R Atkuri
    Department of Genetics, School of Medicine, Stanford University, B007 Beckman Center, 279 Campus Drive, Stanford University, CA 94305 5318, United States
    Curr Opin Pharmacol 7:355-9. 2007
    ....
  48. ncbi Anti- and pro-oxidant activity of rutin and quercetin derivatives
    Marc Kessler
    Laboratoire de Chimie Therapeutique, Faculté de Pharmacie de Strasbourg, 74 route du Rhin, BP 24, F 67401 Illkirch, France
    J Pharm Pharmacol 55:131-42. 2003
    ..This unexpected behaviour could explain, in part, the observed toxicity of some flavonoids in-vivo...
  49. ncbi Antioxidant activity of anthocyanins and their aglycons
    Marja P Kähkönen
    Department of Applied Chemistry and Microbiology, Division of Food Chemistry, P O Box 27, FIN 00014 University of Helsinki, Finland
    J Agric Food Chem 51:628-33. 2003
    ..In LDL the aglycons showed in general higher activities than the glycosides. In bulk oil, to the contrary, the glycosides were more effective than the aglycons...
  50. ncbi Antioxidant activity of sulfated polysaccharide fractions extracted from Undaria pinnitafida in vitro
    Tingting Hu
    School of Life Sciences, Anhui University, Feixi Street, Hefei 230039, PR China
    Int J Biol Macromol 46:193-8. 2010
    ..Available data obtained by in vitro models suggested that the correlation between the sulfate content and antioxidant activity was positive...
  51. pmc Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro
    Brian J Lee
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Brain Res 1307:22-7. 2010
    ..Edaravone significantly ameliorated this response. These data suggest that free radical scavengers are effective in all cell types of the neurovascular unit, and should still be considered as a potential ..
  52. ncbi Biochemical effects of some pesticides on lipid peroxidation and free-radical scavengers
    B D Banerjee
    Department of Biochemistry, University College of Medical Sciences and Guru Teg Bahadur Hospital, University of Delhi, Shahdara, India
    Toxicol Lett 107:33-47. 1999
    ..Increased lipid peroxidation, coupled with altered levels of GSH and OFR scavenging enzymes in the blood are discussed in the light of oxidative stress...
  53. ncbi Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain
    Toru Yamashita
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Cereb Blood Flow Metab 29:715-25. 2009
    ....
  54. ncbi Cytotoxic prenylflavanones from Taiwanese propolis
    Chia Nan Chen
    Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan 100, Republic of China
    J Nat Prod 66:503-6. 2003
    ..Furthermore, both propolin A (2) and B (3) are potential antioxidant agents and show strong scavenging effects against most types of free radicals...
  55. ncbi A role for superoxide in gentamicin-mediated nephropathy in rats
    Salvatore Cuzzocrea
    Institute of Pharmacology, University of Messina, Torre Biologica Policlinico Universitario, Via C Valeria Gazzi, 98100 Messina, Italy
    Eur J Pharmacol 450:67-76. 2002
    ....
  56. ncbi Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis
    D C Hooper
    Department of Microbiology and Immunology, Kimmel Cancer Institute, and the Biotechnology Foundation Laboratories, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    FASEB J 14:691-8. 2000
    ....
  57. ncbi Free radical scavenging abilities of flavonoids as mechanism of protection against mutagenicity induced by tert-butyl hydroperoxide or cumene hydroperoxide in Salmonella typhimurium TA102
    R Edenharder
    Department of Hygiene and Environmental Medicine, University of Mainz, Obere Zahlbacher Strasse 67, D 55131 Mainz, Germany
    Mutat Res 540:1-18. 2003
    ..From these results we conclude that in the Salmonella/reversion assay with strain TA102 antimutagenic activities of flavonoids against the peroxide mutagens CHP and BHP are mainly caused by radical scavenging effects...
  58. ncbi Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid)
    Ilhami Gulcin
    Faculty of Arts and Sciences, Department of Chemistry, Ataturk University, TR 25240 Erzurum, Turkey
    Toxicology 217:213-20. 2006
    ..In addition, caffeic acid is an effective ABTS(+) scavenging, DPPH scavenging, superoxide anion radical scavenging, total reducing power and metal chelating on ferrous ions activities...
  59. ncbi Screening of plant extracts for antioxidant activity: a comparative study on three testing methods
    Irina I Koleva
    Laboratory of Organic Chemistry, Wageningen University, Dreijenplein 8, 6703 HB Wageningen, The Netherlands
    Phytochem Anal 13:8-17. 2002
    ..Being rapid, simple and independent of sample polarity, the DPPH method is very convenient for the quick screening of many samples for radical scavenging activity...
  60. ncbi Antioxidant activity of different sulfate content derivatives of polysaccharide extracted from Ulva pertusa (Chlorophyta) in vitro
    Huimin Qi
    Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China
    Int J Biol Macromol 37:195-9. 2005
    ..Thirdly, HU4 (sulfate content, 30.8%) and HU5 (sulfate content, 32.8%) showed more pronounce chelating ability on ferrous ion at high concentration than other samples...
  61. ncbi Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury
    P Zhang
    Department of Anesthesiology, Second Affiliated Hospital of Xi an Jiaotong University School of Medicine, 157 West 5 road, Xi an, Shaanxi 710004, China
    Neuroscience 201:297-306. 2012
    ..05). These findings indicate that administration with edaravone, via repressing HIF-1α signaling pathway, inhibits SVZ neurogenesis in rats after cerebral ischemia-reperfusion injury...
  62. ncbi Antioxidant activity of L-adrenaline: a structure-activity insight
    Ilhami Gulcin
    Ataturk University, Faculty of Sciences, Department of Chemistry, TR 25240 Erzurum, Turkey
    Chem Biol Interact 179:71-80. 2009
    ..Moreover, this study will bring an innovation for further studies related to antioxidant properties of L-adrenaline. According to present study, L-adrenaline had effective in vitro antioxidant and radical scavenging activity...
  63. ncbi Attenuation of radiation-induced genomic instability by free radical scavengers and cellular proliferation
    C L Limoli
    Department of Radiology, University of California, San Francisco, CA, USA
    Free Radic Biol Med 31:10-9. 2001
    ..the mechanisms of radiation-induced chromosomal instability, cells were irradiated in the presence of the free radical scavengers DMSO, glycerol, or cysteamine, in the presence of DMSO while frozen, or held in confluence arrest post-..
  64. pmc Global inhibition of reactive oxygen species (ROS) inhibits paclitaxel-induced painful peripheral neuropathy
    Mehmet Fidanboylu
    Wolfson Centre for Age Related Diseases, Centre for Integrative Biomedicine, King s College London, London, United Kingdom
    PLoS ONE 6:e25212. 2011
    ..These data suggest that ROS play a causal role in the development and maintenance of paclitaxel-induced pain, but such effects cannot be attributed to superoxide radicals alone...
  65. ncbi Exploring Equisetum arvense L., Equisetum ramosissimum L. and Equisetum telmateia L. as sources of natural antioxidants
    Dubravka Stajner
    Faculty of Agriculture, University of Novi Sad, Trg Dositeja Obradovica 8, 21000 Novi Sad, Serbia and Montenegro
    Phytother Res 23:546-50. 2009
    ..9% indicating that Equisetum telmateia could be a useful source of antioxidants with huge scavenging ability...
  66. ncbi Antioxidant activity and protective effect against plasmid DNA strand scission of leaf, bark, and heartwood extracts from Acacia catechu
    Sanjay Guleria
    Div of Biochemistry and Plant Physiology, SK Univ of Agricultural Sciences and Technology, Chatha 180 009, Jammu, India
    J Food Sci 76:C959-64. 2011
    ..Furthermore, the ethyl acetate and acetone fractions of heartwood significantly protected pBR322 supercoiled plasmid DNA against strand scission induced by hydroxyl radicals in a Fenton's reaction mixture...
  67. ncbi Electrocardiographic and biochemical evidence for the cardioprotective effect of antioxidants in acute doxorubicin-induced cardiotoxicity in the beagle dogs
    Yanfei Xin
    State Key Laboratory of Safety Evaluation for New Drugs, Center of Safety Evaluation, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang 310013, China
    Biol Pharm Bull 34:1523-6. 2011
    ..All these results confirm and extend previous observations in rats concerning the effectiveness of LBP or EDA against DOX-induced cardiomyopathy...
  68. ncbi Donor antioxidant strategy prolongs cardiac allograft survival by attenuating tissue dendritic cell immunogenicity(†)
    M Jurewicz
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital, Boston, MA, USA
    Am J Transplant 11:348-55. 2011
    ..These data for the first time establish a basis for donor anti-ischemic strategies, which in the ever-expanding marginal donor pools, can be instituted to promote engraftment...
  69. ncbi Antioxidant and free radical scavenging activities of Terminalia chebula
    Hua Yew Cheng
    Graduate Institute of Pharmaceutical Science, Kaohsiung Medical University, Taiwan
    Biol Pharm Bull 26:1331-5. 2003
    ..chebula exhibited antioxidant activity at different magnitudes of potency. The antioxidant activity of each pure compound was derived from different pathways and was suggested to be specific...
  70. ncbi C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation
    Yuji Miyazaki
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Arterioscler Thromb Vasc Biol 31:1124-32. 2011
    ..To investigate whether and how the endoplasmic reticulum (ER) stress-induced, CCAAT/enhancer-binding protein-homologous protein (CHOP)-mediated pathway regulates myocardial ischemia/reperfusion injury...
  71. ncbi Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4
    Kiyoshi Kikuchi
    Division of Laboratory and Vascular Medicine, Field of Cardiovascular and Respiratory Disorders, Department of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Biochem Biophys Res Commun 390:1121-5. 2009
    ..In light of observations that edaravone specifically inhibited AQP4 in a rat transient focal ischemia model, we propose that edaravone might reduce cerebral edema through the inhibition of AQP4 expression following cerebral infarction...
  72. ncbi Oral administration of copper to rats leads to increased lymphocyte cellular DNA degradation by dietary polyphenols: implications for a cancer preventive mechanism
    Husain Y Khan
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, India
    Biometals 24:1169-78. 2011
    ..In this context, it may be noted that cancer cells are under considerable oxidative stress and increasing such stress to cytotoxic levels could be a successful anticancer approach...
  73. ncbi Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo
    Jun ichi Oyama
    Department of Cardiovascular, Respiratory, and Geriatric Medicine, Kyushu University Hospital at Beppu and Medical Institute of Bioregulation, Kyushu University, Oita, Japan
    Heart Vessels 25:379-85. 2010
    ..Therefore, the current results suggest that scavenging free radicals has a beneficial effect for patients with coronary endothelial dysfunction...
  74. pmc Nanoceria exhibit redox state-dependent catalase mimetic activity
    Talib Pirmohamed
    Burnett School of Biomedical Science, 4000 Central Florida Blvd, Bldg 20 Room 124, Orlando, Florida, USA
    Chem Commun (Camb) 46:2736-8. 2010
    ..Surprisingly, the catalase mimetic activity correlates with a reduced level of cerium in the +3 state, in contrast to the relationship between surface charge and superoxide scavenging properties...
  75. ncbi Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs
    Esaú Floriano-Sánchez
    Escuela Superior de Medicina del Instituto Politecnico Nacional, Plan de San Luis y Salvador Díaz Mirón S N, Col Casco de Santo Tomas, Mexico, Mexico
    Free Radic Res 40:523-33. 2006
    ..It is concluded that NDGA is a potent in vitro scavenger of ONOO(-), (1)O(2), OH(v), and HOCl and is able to prevent lung tyrosine nitration in vivo...
  76. ncbi The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells
    Kiyoshi Kikuchi
    Division of Laboratory and Vascular Medicine, Field of Cardiovascular and Respiratory Disorders, Department of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Science, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    J Pharmacol Exp Ther 329:865-74. 2009
    ..Furthermore, edaravone (3-30 microM) blocked HMGB1-triggered apoptosis in PC12 cells. Our findings suggest a novel neuroprotective mechanism for edaravone that abrogates the release of HMGB1...
  77. ncbi Modification of fibrin structure as a possible cause of thrombolytic resistance
    Boguslaw Lipinski
    Department of Genetics and Epidemiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    J Thromb Thrombolysis 29:296-8. 2010
    ..resistance of thrombi older than 3 h to proteolytic degradation may be abrogated by the administration of free radical scavengers, particularly those that can be neutralized by virtue of aromatic hydroxylation, such as salicylates and ..
  78. ncbi TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion
    Mahmoud M Khattab
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
    Eur J Pharmacol 548:167-73. 2006
    ..This raises the chances for considering pharmacologic interventions that interrupt superoxide anion and peroxynitrite stress for putative alternative agents as anti-inflammatory analgesic new medical strategies...
  79. ncbi Antioxidative activities of oolong tea
    Qin Yan Zhu
    Departments of Nutrition and Internal Medicine, University of California, Davis, California 95616 8669, USA
    J Agric Food Chem 50:6929-34. 2002
    ..The present results support the concept that oolong tea contains several low molecular weight antioxidants that may have health promotion activities...
  80. ncbi Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B
    Guang Rong Zhao
    Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, P O Box 6888, Tianjin 300072, PR China
    Food Chem Toxicol 46:73-81. 2008
    ..Their radical scavenging and antioxidant properties might have potential applications in food and healthcare industry...
  81. ncbi Nitric oxide reduces seed dormancy in Arabidopsis
    Paul C Bethke
    Department of Plant and Microbial Biology, 111 Koshland Hall, University of California, Berkeley, CA 94720 3102, USA
    J Exp Bot 57:517-26. 2006
    ..It was confirmed that NO plays a role in reducing seed dormancy by using purified NO gas, and a model to explain how nitrogen-containing compounds may break dormancy in Arabidopsis is presented...
  82. ncbi Alkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stress
    Jorge Garrido
    CIQ Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169 007 Porto, Portugal
    Biochimie 94:961-7. 2012
    ..These compounds could have useful applications in conditions where oxidative stress plays a pathogenic role...
  83. ncbi Curcumin: from ancient medicine to current clinical trials
    H Hatcher
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cell Mol Life Sci 65:1631-52. 2008
    ....
  84. ncbi The lipophilic multifunctional antioxidant edaravone (radicut) improves behavior following embolic strokes in rabbits: a combination therapy study with tissue plasminogen activator
    Paul A Lapchak
    University of California San Diego, Department of Neuroscience, 9500 Gilman Drive MTF316, La Jolla, CA 92093 0624, USA
    Exp Neurol 215:95-100. 2009
    ..Edaravone can also be administered with a thrombolytic to improve behavior...
  85. ncbi Natural antioxidants: fascinating or mythical biomolecules?
    Ashwell R Ndhlala
    Research Centre for Plant Growth and Development, School of Biological and Conservation Sciences, University of KwaZulu Natal Pietermaritzburg, Private Bag X01, Scottsville 3209, South Africa
    Molecules 15:6905-30. 2010
    ....
  86. ncbi In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice
    Ning Liu
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Brain Res 1397:66-75. 2011
    ....
  87. ncbi Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury
    B J Day
    Department of Biochemistry, Duke University, Durham, North Carolina 27710, USA
    Arch Biochem Biophys 347:256-62. 1997
    ..These data suggest that manganic porphyrins may be useful therapeutics against disease states associated with the overproduction of reactive oxygen species...
  88. ncbi Edaravone, a free radical scavenger, ameliorates experimental autoimmune encephalomyelitis
    Masayuki Moriya
    Department of Neurology D 4, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Neurosci Lett 440:323-6. 2008
    ..A reduction of both the cellular infiltration and the expression of iNOS may therefore underlie the mechanisms of the beneficial effect of edaravone on EAE...
  89. ncbi Edaravone, a free radical scavenger, in the treatment of idiopathic sudden sensorineural hearing loss with profound hearing loss
    Hajime Sano
    Department of Otolaryngology, Kitasato University, School of Medicine, 1 15 1 Kitasato Sagamihara, Kanagawa 228 8555, Japan
    Auris Nasus Larynx 37:42-6. 2010
    ..The aim of this study was to investigate whether edaravone could improve treatment result in idiopathic sudden sensorineural hearing loss (ISSHL) patients with severe hearing loss...
  90. ncbi Edaravone alleviates delayed neuronal death and long-dated cognitive dysfunction of hippocampus after transient focal ischemia in Wistar rat brains
    L Jiao
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
    Neuroscience 182:177-83. 2011
    ....
  91. ncbi Tronchuda cabbage (Brassica oleracea L. var. costata DC): scavenger of reactive nitrogen species
    Carla Sousa
    REQUIMTE Servico de Farmacognosia, Faculdade de Farmacia, Universidade do Porto, R Anibal Cunha Porto, Portugal
    J Agric Food Chem 56:4205-11. 2008
    ..Among the compounds tested, sinapic acid showed the strongest antioxidant activity against both species...
  92. ncbi Free radical scavengers can differentially modulate the genotoxicity of amsacrine in normal and cancer cells
    Janusz Blasiak
    Department of Molecular Genetics, University of Lodz, Lodz, Poland
    Mutat Res 535:25-34. 2003
    ..Amifostine may potentate DNA-damage effect of amsacrine in cancer cells and decrease this effect in normal cells and Vitamin C can be considered as a protective agent against DNA damage in normal cells...
  93. ncbi Polyphenol contents and antioxidant activity of lyophilized aqueous extract of propolis from Erzurum, Turkey
    Ilhami Gulcin
    Faculty of Sciences, Department of Chemistry, TAtatürk University, R 25240 Erzurum, Turkey
    Food Chem Toxicol 48:2227-38. 2010
    ..This study will bring an innovation for further studies with regard to the antioxidant properties of LAEP...
  94. pmc A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy?
    Paul A Lapchak
    Department of Neurology, Cedars Sinai Medical Center, 8730 Alden Drive, Thalians E216, Los Angeles, CA 90048, USA
    Expert Opin Pharmacother 11:1753-63. 2010
    ..With almost 17 years of edaravone clinical experience, a few adverse events--including acute renal failure--have been noted...
  95. pmc Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma
    Colleen G Le Prell
    Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109 0506, USA
    Free Radic Biol Med 42:1454-63. 2007
    ..of this safe and effective antioxidant intervention that attenuates NIHL provides a compelling rationale for human trials in which free radical scavengers are used to eliminate this single major cause of acquired hearing loss.
  96. ncbi Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage
    Takehiro Nakamura
    Department of Neurobiology, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Miki, Kagawa 761 0793, Japan
    Stroke 39:463-9. 2008
    ..Our previous studies have demonstrated that oxidative DNA injury occurs in the brain after intracerebral hemorrhage (ICH). We therefore examined whether edaravone, a free-radical scavenger, could reduce ICH-induced brain injury...
  97. ncbi Antigenotoxic and free radical scavenging activities of extracts from Moricandia arvensis
    I Skandrani
    Unité de Pharmacognosie Biologie Moléculaire 99 UR 07 03, Faculté de Pharmacie de Monastir, Monastir, Tunisia
    Drug Chem Toxicol 30:361-82. 2007
    ..In addition, these two extracts showed important free radical scavenging activity toward the DPPH. radical, whereas the chloroform extract exhibited the highest value of TEAC against ABTS+. radical...
  98. ncbi Free radical scavenging and antiatherogenic activities of Sesamum indicum seed extracts in chemical and biological model systems
    Nishant P Visavadiya
    BRD School of Biosciences, Sardar Patel Maidan, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India
    Food Chem Toxicol 47:2507-15. 2009
    ..The IC(50) values of both extracts were compared with respective antioxidant standards. Overall, ethanolic extract of S. indicum possess strong antioxidant capacity and offering effective protection against LDL oxidation susceptibility...
  99. ncbi Short-term type 1 diabetes alters the mechanism of endothelium-dependent relaxation in the rat carotid artery
    C H Leo
    School of Medical Sciences, RMIT Univ, PO Box 71, Bundoora, Victoria 3083, Australia
    Am J Physiol Heart Circ Physiol 299:H502-11. 2010
    ..In early diabetes, nitrosothiol-mediated opening of K(+) channels may act in conjunction with NO stimulation of sGC to maintain endothelium-dependent relaxation despite the increase in vascular superoxide levels...
  100. ncbi Effect of the free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), on hypoxia-ischemia-induced brain injury in neonatal rats
    Tomoaki Ikeda
    Department of Obstetrics and Gynecology, Miyazaki Medical College, 5200 Kihara, Kiyotake cho, Miyazaki 889 16, Japan
    Neurosci Lett 329:33-6. 2002
    ..The administration of MCI-186 significantly attenuated damage, in a dose-dependent manner. These results indicate that MCI-186 is a promising candidate for the treatment of neonatal hypoxic-ischemic encephalopathy...
  101. ncbi Flavonoid baicalein attenuates activation-induced cell death of brain microglia
    Kyoungho Suk
    Department of Anatomy and Neurobiology, College of Medicine, Gyeongsang National University, 92 Chilam dong, Jinju, Kyungnam 660 751, Korea
    J Pharmacol Exp Ther 305:638-45. 2003
    ..Also, the AICD-inhibiting effects of baicalein were specific for the inflammatory stimulus that activated microglia...

Research Grants63

  1. Roles of Nitric Oxide and Superoxide in Cystitis
    ANTHONY JOHN KANAI; Fiscal Year: 2013
    ..We developed a mitochondrial targeting strategy (U.S. Patent 11/565,779) for NOS antagonists and free radical scavengers, and mouse models where the bladder or descending colon is withdrawn through a small incision and ..
  2. Crystal Associated Renal Inflammation and Treatment Options
    Saeed R Khan; Fiscal Year: 2012
    ..Treatments with anti-oxidants, free radical scavengers, or angiotensin receptor blockers reduce CaOx crystal deposition in the kidneys of experimental animals...
  3. Mechanisms of Virus Induced Motor Neuron Injury and Treatment of Viral Myelitis
    STEPHANIE ANNE SCHITTONE; Fiscal Year: 2010
    ..examined further in reovirus spinal cord injury by treating mice with specific inhibitors of caspase and free radical scavengers in Aim 3...
  4. Signal Transduction in the Heart after Cancer Therapy
    KATHLEEN LOUISE GABRIELSON; Fiscal Year: 2012
    ..Additionally, we will determine the role of free radical scavengers on erbB2 expression and the role of erbB2 pathway inhibition on cellular protection during oxidative ..
  5. Acid-sensing channels as novel target for brain ischemia
    Zhigang Xiong; Fiscal Year: 2009
    ..However, the recent clinical trials using glutamate antagonists and most recently free radical scavengers, have failed to show protection against ischemic injury...
  6. SKIN REACTION TO LIGHT--NORMAL, PHOTOSENSITIVITY, CANCER
    MADHUKAR PATHAK; Fiscal Year: 1992
    ..lysyl hydroxylase, desmosine, isodesmosine, and proteoglycans and evaluation of the role of certain free radical scavengers and antioxidants (e.g...
  7. Development of RLIP767 as a Radiation Countermeasure
    Charles Casey Cunningham; Fiscal Year: 2010
    ..Most therapeutic agents are free radical scavengers which must be present in high concentrations as exposure occurs, making their use as treatments ..
  8. Development of "Active" Biomaterial Scaffolds for Islet Transplantation
    EILEEN PEDRAZA; Fiscal Year: 2010
    ..This research is a significant and necessary step to advancing current therapeutic methods for treating Type 1 diabetes mellitus (T1DM). It will improve the success and efficacy of current and future therapeutic diabetes treatment. ..
  9. Cerium oxide nanoparticles for the treatment of traumatic brain injury
    Beverly A Rzigalinski; Fiscal Year: 2011
    ..reduction of free radical activity thus remains an important avenue of treatment for TBI, yet traditional free radical scavengers may be limited by poor brain penetration, extensive dosing requirements, or both...
  10. ISCHEMIA-REPERFUSION INJURY AFTER LUNG TRANSPLANTATION
    Joel Cooper; Fiscal Year: 1991
    ..Based on preliminary work, testable preservation techniques will include calcium-channel blockers, oxygen free radical scavengers, and flushing with electrolyte solutions of extracellular composition...
  11. OXIDATIVE STRESS IN SEIZURE INDUCED NEURONAL INJURY
    WOLF DIETRICH DETTBARN; Fiscal Year: 1999
    ..in the activities of cytochrome c oxidase and xanthine oxidase, (3) determining whether antioxidants and free radical scavengers prevent increases in F2-isoprostanes and injury such as the endogenous vitamin E and glutathione, ..
  12. MOLECULAR MECHANISMS OF ANTICARCINOGENESIS
    Thomas Kensler; Fiscal Year: 1991
    ..Antioxidants have two major modes of action: (1) inducers of carcinogen detoxication enzymes and (2) free radical scavengers. These mechanisms will be examined in two model systems for experimental carcinogenesis...
  13. NATIONAL ACUTE BRAIN INJURY STUDY--HYPOTHERMIA
    Guy Clifton; Fiscal Year: 1999
    ..A third factor for increasing the sample size is the disappointing results from other multicenter head injury trials. ..
  14. OXYGEN RADICALS AND CARDIAC ADAPTATIONS TO ISCHEMIA
    Roberto Bolli; Fiscal Year: 1999
    ..The oxyradical hypothesis of late preconditioning will be tested by determining whether free radical scavengers prevent late preconditioning and, conversely, whether a free radical-generating system induces late ..
  15. Anti-oxidative gene therapy for liver transplantation
    Jian Wu; Fiscal Year: 2006
    ..To combat these ROS, free radical scavengers, such as superoxide dismutase (SOD) and catalase play crucial roles in the attenuation of hepatic I/R ..
  16. CEREBRAL BLOOD FLOW AND METABOLISM DURING INFANT CPR
    Charles Schleien; Fiscal Year: 1990
    ..In aim 4, we will determine how free radical scavengers can best be administered during CPR to inhibit free radical appearance and whether these agents during ..
  17. DOPAMINE IN NEONATAL HYPOXIC-ISCHEMIC BRAIN INJURY
    Francis Filloux; Fiscal Year: 1992
    ..The ability of dopamine antagonists versus free radical scavengers to protect neurons in culture from excess dopamine will be determined...
  18. CEREBRAL ISCHEMIA AND FREE OXYGEN RADICALS
    Jeffrey Kirsch; Fiscal Year: 1991
    ..times to determine whether changing the interval of ischemia or the administration of oxygen derived free radical scavengers (e.g. superoxide dismutase) has an effect on post ischemic sequela...
  19. EFFICACY OF MOUSE SPERM CRYOPRESERVATION
    LARRY MOBRAATEN; Fiscal Year: 2001
    ..Various modifications of IVF such as addition of free radical scavengers to the culture medium and removal of the zona pellucida from oocytes will be tested for ability to ..
  20. FREE RADICAL AND PEROXIDATIVE DAMAGE IN SPINE
    Danxia Liu; Fiscal Year: 2000
    ..The measurements will be made specific by administering free radical scavengers or inhibitors through the dialysis fiber or cannula...
  21. MYOCARDIAL MEMBRANE PATHOPHYSIOLOGY
    KAREN BURTON; Fiscal Year: 1990
    ..Specific interventions including free radical scavengers, such as superoxide dismutase, catalase and Alpha-tocopheral, and phospholipase inhibitors, such as ..
  22. NITRIC OXIDE AND SHEAR STRESS IN ATHEROGENESIS
    ANTONIO CAYATTE; Fiscal Year: 1999
    ..monocyte adhesion regulated by cytokines and lyso-PC, using inhibitors of NO to prevent its production free radical scavengers to prevent NO inactivation by cytokine-induced free radical generation and NO donors to determine ..
  23. ACUTE REPAIR OF SPINAL INJURY WITH FUSOGENS
    Richard Borgens; Fiscal Year: 2002
    ..They further intend to test PEG derivatives that further reduce nerve fiber destruction (by complexed free radical scavengers) and facilitate nerve impulse conduction (by complexed potassium channel blockers)...
  24. Radical Scavengers for Brain Ischemia Reperfusion injury
    Howard Elford; Fiscal Year: 2003
    ..These compounds are very effective free radical scavengers. They have been shown to reduce inflammatory injury, to lower the level of deleterious cytokines, to ..
  25. PANCREATIC PRESERVATION FOR CLINICAL TRANSPLANTATION
    FOLKERT BELZER; Fiscal Year: 1991
    ..for optimal preservation, and v) how drugs affect preservation quality including antioxidants and oxygen free radical scavengers. This study ill make available a preservation solution effective for relatively long-term storage of ..
  26. Acid-sensing channels as novel target for brain ischemia
    Zhigang Xiong; Fiscal Year: 2010
    ..However, the recent clinical trials using glutamate antagonists and most recently free radical scavengers, have failed to show protection against ischemic injury...
  27. Development and Testing of a Neuroprotective Solution
    Yanming Wang; Fiscal Year: 2003
    ..date, a broad spectrum of compounds with disparate mechanisms of action have been considered, from oxygen free radical scavengers, calcium channel blockers, glutamate receptor antagonists to monoclonal antibodies that attempt to ..
  28. NITRITE/COLLAGEN REACTIONS IN AGING AND SMOKING
    David Paik; Fiscal Year: 2003
    ..Finally, we will examine the effectiveness of free radical scavengers such as vitamins A, C and E to modulate these reactions in vitro...
  29. 'Novel Cancer Drugs to Prevent Doxorubicin Toxicity'
    Howard Elford; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATIONS: MFH's anticancer drugs, Didox and Trimidox, are strong free radical scavengers and Fe chelafors, properties which should protect against the cardiotoxicity that limits the usefulness ..
  30. CARDIAC PROTEIN SYNTHESIS: ISCHEMIA, OVERLOAD & ETHANOL
    SIDNEY SCHREIBER; Fiscal Year: 1991
    ..and evaluate methods to restore or preserve protein synthesis during reperfusion with agents as free radical scavengers, polyamines and stimulants of protein synthesis...
  31. THERAPEUTIC EFFECT OF EMFS ON NEURAL PROCESSES/FUNCTIONS
    JEREMY TUTTLE; Fiscal Year: 2004
    ..The results of these largely exploratory experiments will outline likely basic biological processes capable of responding to EMF with a desirable therapeutic effect. ..
  32. FREE RADICAL INJURY IN REVERSIBLE BRAIN ISCHEMIA
    NINA SOLENSKI; Fiscal Year: 2000
    ..free radicals in ischemic neuronal death would lead to the development of highly specific exogenous free radical scavengers or the ability to pharmacologically manipulate known modulatory factors...
  33. NITRIC OXIDE PRODUCTION IN CARDIAC ALLOGRAFT REJECTION
    T Ferguson; Fiscal Year: 1999
    ....
  34. NITROGENOUS LIGANDS AND HEPATIC MONOOXYGENASES
    HOWARD SHERTZER; Fiscal Year: 1980
    ..using these substrates; and e) influence the effects of sulfhydryl reagents, sulfhydryl inhibitors, and free radical scavengers on enzyme activity and substrate binding...
  35. MICROVASCULAR CHARACTERISTICS OF DIABETES MELLITUS
    HAROLD BOHLEN; Fiscal Year: 2002
    ..If oxidants initially destroy nitric oxide during hyperglycemia, pretreatment with oxygen free radical scavengers will maintain the nitric oxide concentration during the early phase of hyperglycemia...
  36. FREE RADICALS AND MUSCLE DYSFUNCTION IN HEART FAILURE
    GERALD SUPINSKI; Fiscal Year: 2005
    ..free radicals in inducing muscle weakness and excessive fatiguability by determining if administration of free radical scavengers to heart failure animals preserves normal muscle function...
  37. VASCULAR ADAPTATION IN PATHOPHYSIOLOGY
    JOSEPH UNTHANK; Fiscal Year: 2007
    ..Specific enzymes, enzyme inhibitors, and free radical scavengers will be used to determine the role of NO and reactive oxygen species...
  38. ORGAN CULTURE TECHNOLOGY FOR IN VITRO TOXICOLOGY
    RICHARD SPALL; Fiscal Year: 1991
    ..They would be cultured in media that also contain protective agents (antioxidants and free radical scavengers)...
  39. ANTINEOPLASTIC POLYAMINE ANALOGUES
    Patrick Woster; Fiscal Year: 2004
    ..has led to the discovery that the natural polyamines may have the important function of acting as free radical scavengers in protecting chromatin from reactive oxygen species attack...
  40. MEASUREMENT OF FREE RADICAL GENERATION IN THE HEART
    Jay Zweier; Fiscal Year: 1991
    ..generation in the heart have been indirect, documenting beneficial effects of the administration of free radical scavengers. There has been a great need for a technique which is capable of directly detecting and quantitating free ..
  41. TOXIC OXYGEN SPECIES MEDIATE ACUTE LUNG INJURY
    Gerald Rosen; Fiscal Year: 1993
    ..4. Cellular metabolism of free radicals will be studied using free radical scavengers and by liposome mediated augmentation of intracellular antioxidant defenses. 5...
  42. Programmed Cell Death and DNA Damage Signals
    Janice Naegele; Fiscal Year: 2006
    ..Our fourth aim will extend these studies to ask whether exogenous growth factors or free radical scavengers can delay or prevents downstream apoptotic signaling in NHEJ deficient mice.
  43. OXIDATIVE STRESS AND CATARACT FORMATION
    Shambhu D Varma; Fiscal Year: 2010
    ..Along with monitoring inhibition of lens opacification, mechanism of action of EP will be ascertained at the levels of morphology, histology, tissue metabolism and apoptotic changes. ..
  44. MICROGLIAL ACTIVATION IN TRAUMATIC BRAIN INJURY
    Beverly Rzigalinski; Fiscal Year: 2004
    ....
  45. Nanoparticles As Promoters of Cell Longevity
    Beverly Rzigalinski; Fiscal Year: 2006
    ..These studies will provide substantial insight into the pathology of aging and age-associated disorders and initiate a nanotechnological approach to pharmacotherapy. ..
  46. HYDROXYNONENAL MODIFICATION OF SUPEROXIDE DISMUTASE
    Kenneth Hensley; Fiscal Year: 2002
    ..abstract_text> ..
  47. CALCIUM AND THE PATHOPHYSIOLOGY OF THE ADULT HEART CELL
    ROBERT HAWORTH; Fiscal Year: 2001
    ....
  48. Transplantation of Reduced-Size Fatty Livers
    Zhi Zhong; Fiscal Year: 2010
    ....
  49. Mechanisms of In Vivo Ethanol-Induced Mitochondrial Depolarization
    Zhi Zhong; Fiscal Year: 2010
    ....
  50. Endothelial Dysfunction in Intestinal Radiation Toxicity
    Martin Hauer Jensen; Fiscal Year: 2009
    ..This project may thus facilitate development of specific strategies to minimize intestinal radiation toxicity, thereby making radiation therapy safer and more effective. ..
  51. p38 MAP Kinase and Akt Interaction in HUVEC
    Shehla Pervin; Fiscal Year: 2008
    ..This investigation could help us understand the mechanisms by which the mortality rate of male fetus and neonates is higher than female. [unreadable] [unreadable] [unreadable]..
  52. REVERSAL OF DNA DAMAGE BY ALTERNATIVE EXCISION REPAIR
    PAUL DOETSCH; Fiscal Year: 2005
    ..Biochemical characterization of the components of the AER pathway and potentially related pathways will continue as well as studies aimed at determining the range of organisms which utilize Uve1p-like proteins for DNA repair. ..
  53. MOLECULAR PATHOGENESIS OF RADIATION ENTEROPATHY
    Martin Hauer Jensen; Fiscal Year: 2005
    ..This project may facilitate development of specific strategies to minimize intestinal radiation toxicity, thereby making radiation therapy safer and more effective. ..
  54. CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING
    Michael Cohen; Fiscal Year: 2006
    ..Finally, I will see if NECA's salvage of myocardium at reperfusion translates into rapid functional benefits. It is hoped that the potential of this new pharmacologic approach can be defined. ..
  55. GENETIC DETERMINANTS OF MULTISTEP ORAL TUMORIGENESIS
    Walter Hittelman; Fiscal Year: 2006
    ..abstract_text> ..
  56. MICROVASCULAR OCCLUSION IN ACUTE FOCAL CEREBRAL ISCHEMIA
    Gregory Del Zoppo; Fiscal Year: 2004
    ..These studies are a direct extension of completed work of this proposal, and are expected to add greatly to the understanding of how vascular ischemia affects neuron integrity with testable treatment strategies. ..
  57. A tyrosinase-targeted drug design for the treatment of melanoma
    Majid Moridani; Fiscal Year: 2007
    ..In this work we will be developing novel phenol based drugs for treatment of melanoma. [unreadable] [unreadable] [unreadable]..
  58. Winship Cancer Institute, Emory University
    PAUL DOETSCH; Fiscal Year: 2007
    ..abstract_text> ..
  59. Novel Neuroprotectants for TBI
    Edward Hall; Fiscal Year: 2008
    ..Thousands experience long lasting brain injury that interferes with their ability to lead productive and full lives. We plan to test a promising new class of therapeutics for traumatic brain injury. [unreadable] [unreadable] [unreadable]..
  60. Role of Oxidatve Stress in Chronic Beryllium Disease
    Brian Day; Fiscal Year: 2006
    ..These studies have the potential to further define the etiology of CBD, risk factors, and suggest novel approaches to prevent and treat this disease. ..
  61. Pharmacotherapy for Minor Depression
    Andrew Nierenberg; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  62. Improving Survival For Small-For-Size Liver Grafts
    Zhi Zhong; Fiscal Year: 2004
    ..This work will develop mechanism-based strategies to increase the use and improve the outcome of partial livers for transplantation in the clinic. ..