antimetabolites

Summary

Summary: Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033)

Top Publications

  1. pmc A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus
    Xiao lei Zhang
    Department of Cell Biology and Anatomy, New York Medical College, Basic Sciences Building, Room 217, Valhalla, NY 10595, USA
    Neuropharmacology 55:1238-50. 2008
  2. pmc Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites
    Ryan Montano
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Mol Cancer Ther 11:427-38. 2012
  3. ncbi Ex vivo application of carbon monoxide in University of Wisconsin solution to prevent intestinal cold ischemia/reperfusion injury
    A Nakao
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pennsylvania, USA
    Am J Transplant 6:2243-55. 2006
  4. ncbi Effect of 2-deoxy-D-glucose on various malignant cell lines in vitro
    Xiao Dong Zhang
    Groupe Régional d Etudes sur le Cancer Grecan, Unité Biologie et Thérapies Innovantes des Cancers Localement Agressifs, CLCC François Baclesse, Caen, France
    Anticancer Res 26:3561-6. 2006
  5. pmc 2-deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines
    O Zagorodna
    Department of Pathology, University of Iowa, Iowa City, IA 52242, USA
    Oncogene 31:2738-49. 2012
  6. ncbi RS 67333 and D-cycloserine accelerate learning acquisition in the rat
    V Lelong
    , Laboratoire de Pharmacologie, , UFR des Sciences Pharmaceutiques, , 14032 Caen Cedex, France
    Neuropharmacology 41:517-22. 2001
  7. ncbi 5-Aminolaevulinic acid methyl ester transport on amino acid carriers in a human colon adenocarcinoma cell line
    O A Gederaas
    Institute of Laboratory Medicine, Department of Clinical Chemistry, Medical Faculty, Norwegain University of Science and Technology, Trondheim, Norway
    Photochem Photobiol 73:164-9. 2001
  8. pmc Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine
    Donald Lavelle
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Blood 119:1240-7. 2012
  9. ncbi Different substrate recognition motifs of human and trypanosome nucleobase transporters. Selective uptake of purine antimetabolites
    Lynsey J M Wallace
    Institute of Biomedical and Life Sciences, Division of Infection and Immunity, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
    J Biol Chem 277:26149-56. 2002
  10. ncbi Effects of single prolonged stress and D-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD
    Shigeto Yamamoto
    Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima, Japan
    Neuropsychopharmacology 33:2108-16. 2008

Detail Information

Publications247 found, 100 shown here

  1. pmc A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus
    Xiao lei Zhang
    Department of Cell Biology and Anatomy, New York Medical College, Basic Sciences Building, Room 217, Valhalla, NY 10595, USA
    Neuropharmacology 55:1238-50. 2008
    ..Our data suggest that GLYX-13 may have unique therapeutic potential as a learning and memory enhancer because of its ability to simultaneously enhance LTP and suppress LTD...
  2. pmc Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites
    Ryan Montano
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Mol Cancer Ther 11:427-38. 2012
    ..Delayed administration of SCH900776 may be more effective than concurrent treatment. SCH900776 is currently in phase I clinical trials, and these results provide the rationale and schedule for future clinical trials...
  3. ncbi Ex vivo application of carbon monoxide in University of Wisconsin solution to prevent intestinal cold ischemia/reperfusion injury
    A Nakao
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pennsylvania, USA
    Am J Transplant 6:2243-55. 2006
    ..The study suggests that ex vivo CO delivery into UW solution would be a simple and innovative therapeutic strategy to prevent transplant-induced I/R injury...
  4. ncbi Effect of 2-deoxy-D-glucose on various malignant cell lines in vitro
    Xiao Dong Zhang
    Groupe Régional d Etudes sur le Cancer Grecan, Unité Biologie et Thérapies Innovantes des Cancers Localement Agressifs, CLCC François Baclesse, Caen, France
    Anticancer Res 26:3561-6. 2006
    ..Although cancer cells have been reported to be strongly dependent on glycolysis (Warburg effect), very few reports have studied the inhibitory effects of 2-DG on cancer...
  5. pmc 2-deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines
    O Zagorodna
    Department of Pathology, University of Iowa, Iowa City, IA 52242, USA
    Oncogene 31:2738-49. 2012
    ..Bcl-2 inhibition combined with 2DG may be an effective therapeutic strategy for lymphoma...
  6. ncbi RS 67333 and D-cycloserine accelerate learning acquisition in the rat
    V Lelong
    , Laboratoire de Pharmacologie, , UFR des Sciences Pharmaceutiques, , 14032 Caen Cedex, France
    Neuropharmacology 41:517-22. 2001
    ..These data suggest that RS 67333 and D-cycloserine can improve the learning rate in a high demand memory task and confirm that selective 5-HT(4) receptor ligands may provide novel approaches for the development of cognitive enhancers...
  7. ncbi 5-Aminolaevulinic acid methyl ester transport on amino acid carriers in a human colon adenocarcinoma cell line
    O A Gederaas
    Institute of Laboratory Medicine, Department of Clinical Chemistry, Medical Faculty, Norwegain University of Science and Technology, Trondheim, Norway
    Photochem Photobiol 73:164-9. 2001
    ..In conclusion, the cellular uptake of 5-ALA-ME into WiDr cells seems to be due to active transport mechanisms, involving transporters of nonpolar amino acids...
  8. pmc Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine
    Donald Lavelle
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Blood 119:1240-7. 2012
    ..Combining oral THU with oral DAC changes DAC pharmacology in a manner that may facilitate accessible noncytotoxic DNMT1-targeted therapy...
  9. ncbi Different substrate recognition motifs of human and trypanosome nucleobase transporters. Selective uptake of purine antimetabolites
    Lynsey J M Wallace
    Institute of Biomedical and Life Sciences, Division of Infection and Immunity, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
    J Biol Chem 277:26149-56. 2002
    The therapeutic index of antimetabolites such as purine analogues is in large part determined by the extent to which it is selectively accumulated by the target cell...
  10. ncbi Effects of single prolonged stress and D-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD
    Shigeto Yamamoto
    Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima, Japan
    Neuropsychopharmacology 33:2108-16. 2008
    ..These findings suggest that DCS, irrespective of its mechanistic involvement in the enhancement of fear extinction, may help to reverse hippocampal plasticity, and thus reverse the NMDA compensatory alterations...
  11. pmc The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy
    Hagir B Suliman
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 117:3730-41. 2007
    ..These findings imply that the therapeutic index of anthracycline cancer chemotherapeutics can be improved by the protection of cardiac mitochondrial biogenesis...
  12. ncbi [Optimal immunosuppressive therapy based on pharmacokinetics and pharmacodynamics of antimetabolites in clinical practice]
    Takafumi Naito
    Department of Hospital Pharmacy, Hamamatsu University School of Medicine, Shizuoka, Japan
    Yakugaku Zasshi 130:1695-700. 2010
    ..The IMPDH activity might be a useful marker reflecting a long-term exposure by MPA. Our findings in this review would contribute to optimal dosing of MMF in immunosuppressive regimen including a calcineurin inhibitor...
  13. pmc Carbon monoxide protects against ventilator-induced lung injury via PPAR-gamma and inhibition of Egr-1
    Alexander Hoetzel
    Department of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 177:1223-32. 2008
    ..Ventilator-induced lung injury (VILI) leads to an unacceptably high mortality. In this regard, the antiinflammatory properties of inhaled carbon monoxide (CO) may provide a therapeutic option...
  14. ncbi D-cycloserine into the BLA reverses the impairing effects of exposure to stress on the extinction of contextual fear, but not conditioned taste aversion
    Irit Akirav
    Department of Psychology, University of Haifa, Haifa 31905, Israel
    Learn Mem 16:682-6. 2009
    ..This may suggest that the dysfunctional extinction of fear and taste aversion following exposure to a stressful experience may be modulated by different mechanisms...
  15. ncbi Stimulation of alpha-1 adrenergic receptors facilitates spatial learning in rats
    T Puumala
    A I Virtanen Institute, University of Kuopio, Finland
    Eur Neuropsychopharmacol 8:17-26. 1998
    ..In addition, these results suggest that D-cycloserine may be effective in alleviating states of central cholinergic hypofunction...
  16. pmc Gene set analysis of purine and pyrimidine antimetabolites cancer therapies
    Brooke L Fridley
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Pharmacogenet Genomics 21:701-12. 2011
    ..Application of such methods to pharmacogenomic studies may enable the detection of more subtle effects of multiple genes in the same pathway that may be missed by assessing each gene individually...
  17. ncbi Allopurinol safely and effectively optimizes tioguanine metabolites in inflammatory bowel disease patients not responding to azathioprine and mercaptopurine
    M P Sparrow
    Section of Gastroenterology, University of Chicago Medical Center, Chicago, IL 60637, USA
    Aliment Pharmacol Ther 22:441-6. 2005
    ....
  18. pmc Antibiotic evaluation and in vivo analysis of alkynyl Coenzyme A antimetabolites in Escherichia coli
    Andrew C Mercer
    Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0358, USA
    Bioorg Med Chem Lett 18:5991-4. 2008
    ..Our findings suggest that a secondary structure-activity relationship is an important factor in the antibiotic activity of these compounds...
  19. ncbi 2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure
    Mireia Garriga-Canut
    Department of Neurology, Medical Science Center, Room 1715, University of Wisconsin Madison, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Nat Neurosci 9:1382-7. 2006
    ..The metabolic regulation of neuronal genes by CtBP will open avenues of therapy for neurological disorders and cancer...
  20. ncbi Use of carbon monoxide as a therapeutic agent: promises and challenges
    Roberta Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, HA1 3UJ, Harrow, Middlesex, UK
    Intensive Care Med 34:649-58. 2008
    ....
  21. ncbi Carbon monoxide inhalation rescues mice from fulminant hepatitis through improving hepatic energy metabolism
    Tung Yu Tsui
    Department of Surgery, University of Regensburg Medical Centre, Regensburg, Germany, and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Shock 27:165-71. 2007
    ..Up to 90% of mice given CO survived for more than 7 days, whereas control mice died within 12 h. The data provide novel insight of CO-mediated cytoprotection...
  22. ncbi Carbon monoxide can prevent acute lung injury observed after ischemia reperfusion of the lower extremities
    Cherif Boutros
    Laboratory of the Study of Cardiac Grafts and Protheses, Broussias Hospital, Paris, France
    J Surg Res 143:437-42. 2007
    ..The aim of this study was to assess the role of exogenous administration of the end-products of heme oxygenase reaction, carbon monoxide, and bilirubin, in the severity of ALI...
  23. ncbi Immunomodulatory therapy for ocular inflammatory disease: a basic manual and review of the literature
    Annabelle A Okada
    Department of Ophthalmology, Kyorin University School of Medicine, 6 20 2, Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Ocul Immunol Inflamm 13:335-51. 2005
    ..Immunomodulatory agents include the broad categories of antimetabolites (azathioprine, methotrexate, mycophenolate mofetil), alkylating agents (cyclophosphamide, chlorambucil), T-..
  24. ncbi The role of antimetabolites in filtration surgery for neovascular glaucoma: intermediate-term follow-up
    Dario Sisto
    Department of Ophthalmology and Otorhinolaryngology, University of Bari, Bari, Italy
    Acta Ophthalmol Scand 85:267-71. 2007
    To compare the intermediate-term efficacy of 5-fluorouracil (5-FU) and Mitomycin C (MMC) as adjunctive antimetabolites in neovascular glaucoma (NVG) filtration surgery.
  25. ncbi The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites
    Daniel Broderick Longley
    Department of Oncology, Cancer Research Centre, Queen s University Belfast, Belfast, Northern Ireland
    Clin Cancer Res 10:3562-71. 2004
    ..Our results indicate that Fas is an important mediator of apoptosis in response to both 5-FU and antifolates...
  26. pmc A randomised, prospective study comparing trabeculectomy augmented with antimetabolites with a viscocanalostomy technique for the management of open angle glaucoma uncontrolled by medical therapy
    D P S O'Brart
    Department of Ophthalmology, St Thomas s Hospital, London SE1 7EH, UK
    Br J Ophthalmol 86:748-54. 2002
    ..To compare trabeculectomy with viscocanalostomy for the control of intraocular pressure (IOP) in open angle glaucoma (OAG) uncontrolled by medical therapy...
  27. pmc Trabeculectomy and antimetabolites
    S Fraser
    Br J Ophthalmol 88:855-6. 2004
  28. ncbi Adjuvant clodronate treatment does not reduce the frequency of skeletal metastases in node-positive breast cancer patients: 5-year results of a randomized controlled trial
    T Saarto
    Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
    J Clin Oncol 19:10-7. 2001
    ..However, clodronate seems to have a negative effect on DFS by increasing the development of nonskeletal metastases...
  29. ncbi Randomized, placebo-controlled trial of clodronate in patients with primary operable breast cancer
    Trevor Powles
    Royal Marsden National Health Service Trust, Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK
    J Clin Oncol 20:3219-24. 2002
    ..Given to patients with primary breast cancer, clodronate might reduce the subsequent incidence of bone metastases...
  30. ncbi Cell lineage and differentiation in taste buds
    Hirohito Miura
    Department of Oral Physiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Arch Histol Cytol 69:209-25. 2006
    ..Problems in the application of NCAM for the type III cell marker are also discussed...
  31. ncbi Management of primary pterygia using free conjunctival and limbal-conjunctival autografts without antimetabolites
    Luis F Mejía
    Cornea Service, Instituto de Ciencias de la Salud CES, Medellin, Colombia
    Cornea 24:972-5. 2005
    To report the incidence of recurrence after primary pterygium surgery using either a free conjunctival or limbal-conjunctival autograft without antimetabolites.
  32. pmc Identification of the biosynthetic gene cluster for the Pseudomonas aeruginosa antimetabolite L-2-amino-4-methoxy-trans-3-butenoic acid
    Xiaoyun Lee
    Département de Microbiologie Fondamentale, Universite de Lausanne, Lausanne, Switzerland
    J Bacteriol 192:4251-5. 2010
    ..Overexpression of this cluster in strain PA7, a natural AMB-negative isolate, led to AMB overproduction...
  33. ncbi Observations on the use of allopurinol in combination with azathioprine or mercaptopurine
    J A Duley
    Aliment Pharmacol Ther 22:1161-2. 2005
  34. pmc Selective modulation of some forms of schaffer collateral-CA1 synaptic plasticity in mice with a disruption of the CPEB-1 gene
    Juan M Alarcon
    College of Physicians and Surgeons of Columbia University, Columbia University, New York, New York 10032, USA
    Learn Mem 11:318-27. 2004
    ..These data suggest that CPEB-1 contributes in the translational control of mRNAs that is critical only for some selected forms of LTP and LTD...
  35. pmc Dynamics of subgenomic hepatitis C virus replicon RNA levels in Huh-7 cells after exposure to nucleoside antimetabolites
    Lieven J Stuyver
    Pharmasset, Inc, Tucker, Georgia 30084, USA
    J Virol 77:10689-94. 2003
    Treatment with antimetabolites results in chemically induced low nucleoside triphosphate pools and cell cycle arrest in exponentially growing cells...
  36. ncbi A strong nerve dependence of sonic hedgehog expression in basal cells in mouse taste bud and an autonomous transcriptional control of genes in differentiated taste cells
    Hirohito Miura
    National Food Research Institute, 2 1 12 Kannondai, Tsukuba shi, Ibaraki 305 8642, Japan
    Chem Senses 29:823-31. 2004
    ..These results suggest that most Shh-expressing cells are not mitotically active, but that Shh-expressing cells may be in the early transient developmental state of taste cells in taste buds...
  37. ncbi d-Cycloserine: effects on long-term retention of a conditioned response and on memory for contextual attributes
    C Land
    Department of Psychology, Kent State University, Kent, Ohio, 44242, USA
    Neurobiol Learn Mem 72:158-68. 1999
    ..Taken together, these data suggest that DCS may enhance retention of fear and slow the forgetting of stimulus attributes...
  38. ncbi Carbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs
    Ulrich Goebel
    Department of Anesthesiology and Critical Care Medicine, University Medical Center Freiburg, Germany
    Anesthesiology 108:1025-36. 2008
    ..The authors hypothesized that inhaled carbon monoxide before initiation of CPB would reduce inflammatory response in the lungs...
  39. ncbi D-cycloserine facilitates procedural learning but not declarative learning in healthy humans: a randomized controlled trial of the effect of D-cycloserine and valproic acid on overnight properties in the performance of non-emotional memory tasks
    Kenichi Kuriyama
    Department of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
    Neurobiol Learn Mem 95:505-9. 2011
    ....
  40. pmc Medial prefrontal cortex activation facilitates re-extinction of fear in rats
    Chun hui Chang
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1043, USA
    Learn Mem 18:221-5. 2011
    ..Although neither drug facilitated extinction, they both facilitated the subsequent re-extinction of fear when animals were trained in a drug-free state, suggesting that activating the IL primes behavioral extinction...
  41. ncbi Wound modulation after trabeculectomy by different formulations of antimetabolites in rabbits
    D W Lu
    Department of Ophthalmology, Tri Service General Hospital, Taipei, Taiwan, Republic of China
    J Ocul Pharmacol Ther 16:529-38. 2000
    ..9% NaCl solution. Our study suggested that the use of 5-FU microparticles in promoting the success of trabeculectomy in rabbits is dose-dependent, and its effect is less potent than a single intraoperative application of MMC...
  42. ncbi Problem of dural scarring in recording from awake, behaving monkeys: a solution using 5-fluorouracil
    R L Spinks
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, United Kingdom
    J Neurophysiol 90:1324-32. 2003
    ..It is also possible that this technique may be useful in other situations where there is dural scarring after surgical intervention or injury...
  43. ncbi Ovarian carcinoma cells with low levels of beta-F1-ATPase are sensitive to combined platinum and 2-deoxy-D-glucose treatment
    Emma Hernlund
    Department of Oncology Pathology, Cancer Center Karolinska R8, Karolinska Institutet, Stockholm, Sweden
    Mol Cancer Ther 8:1916-23. 2009
    ..The findings validate targeting cancer cell glucose metabolism for potentiating platinum chemotherapy in EOC and indicate that reduced beta-F1-ATPase/oxidative phosphorylation distinguishes cells that are amenable to this strategy...
  44. ncbi Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites
    Yong Mei Zhang
    Protein Science Division, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 279:50969-75. 2004
    ..Thus, the pantothenamides are pro-antibiotics that inhibit fatty acid synthesis and bacterial growth because of the covalent modification of ACP...
  45. ncbi Bisphosphonates and tumor burden
    Gregory R Mundy
    J Clin Oncol 20:3191-2. 2002
  46. ncbi Loss of atm sensitises p53-deficient cells to topoisomerase poisons and antimetabolites
    A Fedier
    Department of Obstetrics and Gynaecology, Division of Gynaecology, University Hospital of Zurich, Switzerland
    Ann Oncol 14:938-45. 2003
    ..In addition to a profound cancer predisposition, another hallmark of ataxia-telangiectasia is radiosensitivity. Recently, p53-null mouse fibroblasts have been reported to be radiosensitised by the concurrent loss of ATM...
  47. ncbi Restraint stress affects hippocampal cell proliferation differently in rats and mice
    Megan J Bain
    Department of Psychology, Life Sciences Centre, Dalhousie University, Halifax, NS, Canada B3H 4J1
    Neurosci Lett 368:7-10. 2004
    ..Hippocampal cell proliferation appears to respond differently to restraint stress in these species...
  48. ncbi Electroconvulsive seizure treatment increases cell proliferation in rat frontal cortex
    Torsten M Madsen
    Laboratory of Molecular Psychiatry, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 30:27-34. 2005
    ..It is possible that increased proliferation of these cell types in the frontal cortex could reverse the loss of glial cell number and the reduced volume that has been reported in the frontal cortex of depressed patients...
  49. ncbi Induced spreading depression activates persistent neurogenesis in the subventricular zone, generating cells with markers for divided and early committed neurons in the caudate putamen and cortex
    Hiroji Yanamoto
    Laboratory for Cerebrovascular Disorders, Research Institute of National Cardiovascular Center, Japan
    Stroke 36:1544-50. 2005
    ..We determined whether spreading depression, a common epiphenomenon of these conditions, stimulates persistent neurogenesis...
  50. ncbi Voluntary exercise alters the cytoarchitecture of the adult dentate gyrus by increasing cellular proliferation, dendritic complexity, and spine density
    Brennan D Eadie
    Division of Neuroscience, University of British Columbia, Vancouver V6T 1Z4, British Columbia, Canada
    J Comp Neurol 486:39-47. 2005
    ..These results suggest that exercise may be an effective component of therapeutic regimes aimed at improving the functioning of individuals with neuropathologies that involve the degradation of cells in the hippocampus...
  51. pmc Selective impairment of hippocampal neurogenesis by chronic alcoholism: protective effects of an antioxidant
    Daniel G Herrera
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:7919-24. 2003
    ..Moreover, these findings suggest that the impaired neurogenesis may be a mechanism mediating cognitive deficits observed in alcoholism...
  52. ncbi Cerebellar granular cell cultures as an in vitro model for antidepressant drug-induced neurogenesis
    M Zusso
    Department of Pharmacology and Anesthesiology, University of Padova, Italy
    Crit Rev Neurobiol 16:59-65. 2004
    ..These findings suggest that round cells in CGC possess the features and potentials of neural precursors, able to differentiate in mature neural cells upon a pharmacological simulum...
  53. ncbi Urothelial carcinogenesis in the urinary bladder of male rats treated with muraglitazar, a PPAR alpha/gamma agonist: Evidence for urolithiasis as the inciting event in the mode of action
    Mark A Dominick
    Department of Drug Safety Evaluation, Bristol Myers Squibb Co, Evansville, Indiana 47721, USA
    Toxicol Pathol 34:903-20. 2006
    ....
  54. ncbi Sex differences in cell proliferation, cell death and defensive behavior following acute predator odor stress in adult rats
    Erin M Falconer
    Department of Psychology, University of British Columbia, Vancouver, Canada
    Brain Res 975:22-36. 2003
    ..This is the first demonstration of a sex difference in cell proliferation and death in the adult dentate gyrus in response to stress...
  55. ncbi Functional manipulations of acetylcholinesterase splice variants highlight alternative splicing contributions to murine neocortical development
    Amir Dori
    Department of Neurosurgery, Soroka University Medical Center, Beer Sheva, Israel
    Cereb Cortex 15:419-30. 2005
    ..Our findings attribute to alternative splicing events an interactive major role in neocortical development...
  56. ncbi Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocam
    D J David
    Center for Neurobiology and Behavior, Columbia University, New York, New York, USA
    J Pharmacol Exp Ther 321:237-48. 2007
    ....
  57. pmc Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neurons
    G C Harburg
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Neuroscience 144:77-87. 2007
    ..These findings indicate that MOR may play a role in regulating progenitor cell survival and more generally encourage further exploration of how MOR activation can influence hippocampal structure and function...
  58. ncbi Expression of the transcription factor Pax 6 in the adult rat dentate gyrus
    Juan Nacher
    Neurobiology, Cell Biology Department, Universitat de Valencia, Burjassot, Spain
    J Neurosci Res 81:753-61. 2005
    ..However, the expression of Pax 6 in astrocytes and certain mature neurons may indicate the existence of other roles for this transcription factor in this telencephalic region...
  59. ncbi Less neurogenesis and inflammation in the immature than in the juvenile brain after cerebral hypoxia-ischemia
    Lin Qiu
    Institute of Neuroscience and Physiology, Goteborg University, Goteborg, Sweden
    J Cereb Blood Flow Metab 27:785-94. 2007
    ..In summary, contrary to what has been generally assumed, our results indicate that the juvenile brain has a greater capacity for neurogenesis after injury than the immature brain...
  60. ncbi Fibronectin and neuroprotective effect of granulocyte colony-stimulating factor in focal cerebral ischemia
    Zhao Yanqing
    Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
    Brain Res 1098:161-9. 2006
    ....
  61. ncbi The relationship between the termination of cell proliferation and expression of heat-shock protein-25 in the rat developing tooth germ
    Naohiro Nakasone
    Division of Anatomy and Cell Biology of the Hard Tissue, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Eur J Oral Sci 114:302-9. 2006
    ..Thus, HSP-25 protein is suggested to act as a switch between cell proliferation and terminal cyto-differentiation during odontogenesis...
  62. pmc Inflammation is detrimental for neurogenesis in adult brain
    Christine T Ekdahl
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, Biomedical Center A 11, Lund, Sweden
    Proc Natl Acad Sci U S A 100:13632-7. 2003
    ..Our data raise the possibility that suppression of hippocampal neurogenesis by activated microglia contributes to cognitive dysfunction in aging, dementia, epilepsy, and other conditions leading to brain inflammation...
  63. ncbi Seizures, not hippocampal neuronal death, provoke neurogenesis in a mouse rapid electrical amygdala kindling model of seizures
    P D Smith
    Centre for Clinical Neurosciences and Neurological Research, St Vincent s Hospital, Melbourne, Victoria, Australia
    Neuroscience 136:405-15. 2005
    ..To address this we derived a rapid electrical amygdala kindling model in mice known to be resistant to seizure-induced neuronal death as an experimental model of focal seizures and to analyze subsequent neurogenesis...
  64. ncbi Discovery of novel hippocampal neurogenic agents by using an in vivo stable isotope labeling technique
    Mahalakshmi Shankaran
    KineMed, Inc, 5980 Horton Street, Suite 400, Emeryville, CA 94608, USA
    J Pharmacol Exp Ther 319:1172-81. 2006
    ..In conclusion, stable isotope labeling is an efficient, high-throughput in vivo method for measuring hippocampal progenitor cell proliferation that can be used to screen for novel neurogenic drugs...
  65. ncbi Overexpression of p27 Kip 1, probability of cell cycle exit, and laminar destination of neocortical neurons
    T Tarui
    Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cereb Cortex 15:1343-55. 2005
    ..Moreover, they operate prior to postproliferative mechanisms necessary to neocortical laminar assembly...
  66. ncbi PSA-NCAM expression in the rat medial prefrontal cortex
    E Varea
    Neurobiology, Cell Biology Department, Universitat de Valencia, Dr Moliner, 50, 46100 Burjassot, Valencia, Spain
    Neuroscience 136:435-43. 2005
    ....
  67. ncbi Regulation of nestin expression after cortical ablation in adult rat brain
    A G Douen
    Trillium Medical Centre, Mississauga, Ontario, Canada
    Brain Res 1008:139-46. 2004
    ..Confocal microscopy detected several BrdU-positive cells expressing nestin. Taken together, the data support a potential role for nestin reexpression in brain repair...
  68. ncbi A possible role for dopamine D3 receptor stimulation in the induction of neurogenesis in the adult rat substantia nigra
    J M Van Kampen
    Department of Pharmacology, Dalhousie University, Tupper Medical Building, 5850 College Street, Halifax, Nova Scotia, Canada B3H 1X5
    Neuroscience 136:381-6. 2005
    ....
  69. ncbi Sexually dimorphic neurogenesis is topographically matched with the anterior accessory olfactory bulb of the adult rat
    P Peretto
    Department of Animal and Human Biology, University of Turin, Via Accademia Albertina 13, 10123 Turin, Italy
    Cell Tissue Res 306:385-9. 2001
    ..Moreover, we demonstrated that the rate of neurogenesis in the anterior AOB of the two sexes was significantly different...
  70. ncbi Time- and dose-related effects of estradiol and diethylstilbestrol on the morphology and function of the fetal rat testis in culture
    Julie Lassurguere
    GERM INSERM U 435, Universite de Rennes I, Campus de Beaulieu, Bretagne, France
    Toxicol Sci 73:160-9. 2003
    ....
  71. ncbi Rosmarinic acid from Perillae Herba produces an antidepressant-like effect in mice through cell proliferation in the hippocampus
    Naoki Ito
    Department of Clinical Research, Oriental Medicine Research Center, Kitasato University, Tokyo, Japan
    Biol Pharm Bull 31:1376-80. 2008
    ..However, locomotor activities were not affected. These results suggest that RA produces an antidepressant-like effect at least in part via the proliferation of newborn cells in the dentate gyrus of the hippocampus...
  72. ncbi The olfactory conditioning in the early postnatal period stimulated neural stem/progenitor cells in the subventricular zone and increased neurogenesis in the olfactory bulb of rats
    K So
    Department of Neurobiology and Behavior, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    Neuroscience 151:120-8. 2008
    ..These results suggest that olfactory conditioning during the early postnatal period temporally stimulates neurogenesis in the olfactory bulb of rats...
  73. ncbi Inhibition of neuronal nitric oxide synthase enhances cell proliferation in the dentate gyrus of the adrenalectomized rat
    C Park
    Department of Anatomy, College of Medicine, Kyunghee University, Hoeki-Dong 1, Dongdaemun-gu, 130-701, Seoul, South Korea
    Neurosci Lett 309:9-12. 2001
    ..These results indicate that NO may be involved in the cell proliferation in the dentate gyrus of the adrenalecomized rat and that serotonin may mediate the regulatory effect of NO on the cell proliferation in rat dentate gyrus...
  74. ncbi Effects of the ketogenic diet on neurogenesis after kainic acid-induced seizures in mice
    Young Se Kwon
    Department of Pediatrics, College of Medicine, Inha University, Incheon, Republic of Korea
    Epilepsy Res 78:186-94. 2008
    ..In conclusion, our results suggest that the KD enhances neurogenesis, which may be related to its beneficial effects on epilepsy...
  75. ncbi Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury
    Hongtao Wu
    Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA
    J Neurotrauma 25:130-9. 2008
    ....
  76. ncbi Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia
    R L Zhang
    Department of Neurology, Henri Ford Health Sciences Center, Detroit, MI 48202, USA
    Neuroscience 105:33-41. 2001
    ..From these data we suggest that focal cerebral ischemia induces transient and regional specific increases in cell proliferation in the ipsilateral hemisphere and that proliferating progenitor cells may exist in the adult cortex...
  77. ncbi The expression of mRNAs for the proteasome complex is developmentally regulated in the rat mesencephalon
    B F El-Khodor
    Department of Neurology, College of Physicians and Surgeons, Columbia University, Black Building, 650 West 168th Street, New York, NY 10032, USA
    Brain Res Dev Brain Res 129:47-56. 2001
    ..Thus, PA28-alpha and RC6 are developmentally regulated, and they may therefore play a role in developmental cell death or differentiation in neurons of the SN...
  78. ncbi Further evidence for an antidepressant potential of the selective sigma1 agonist SA 4503: electrophysiological, morphological and behavioural studies
    Guillaume Lucas
    Centre de Recherche Fernand Seguin, Universite de Montreal, Montreal, Quebec, Canada
    Int J Neuropsychopharmacol 11:485-95. 2008
    ..Further, the fact that the functional changes occurred within a short time-frame (2-3 d) suggest that this antidepressant potential might have a rapid onset of action...
  79. ncbi Postischemic exercise decreases neurogenesis in the adult rat dentate gyrus
    Yoshiki Yagita
    Stroke Division, Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Neurosci Lett 409:24-9. 2006
    ..These findings suggest that running exercise has a negative effect on neurogenesis in the ischemic hippocampus. This may be important with respect to assessment of therapeutic approaches for functional recovery after stroke...
  80. ncbi Gender and strain influence on neurogenesis in dentate gyrus of young rats
    E Perfilieva
    Institute of Clinical Neuroscience, , Sweden
    J Cereb Blood Flow Metab 21:211-7. 2001
    ..No sex or strain difference was observed in the relative ratio of neurogenesis and gliogenesis...
  81. ncbi Enhanced neurogenesis after transient global ischemia in the dentate gyrus of the rat
    N J Kee
    Department of Physiology, University of Toronto, ON, Canada
    Exp Brain Res 136:313-20. 2001
    ..Additional physiological stimulation after ischemia may be exploited to stimulate maturation of new neurons and to offer new therapeutic strategies for promoting recovery of neuronal circuitry in the injured brain...
  82. ncbi A single peripheral injection of basic fibroblast growth factor (bFGF) stimulates granule cell production and increases cerebellar growth in newborn rats
    Y Cheng
    Department of Neuroscience and Cell Biology, UMDNJ/Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurobiol 46:220-9. 2001
    ..We conclude that a single postnatal injection of bFGF increases granule neuron number and enhances cerebellar growth following mitotic stimulation...
  83. ncbi Insulin-like growth factor I improves aspects of mycophenolate mofetil-impaired anastomotic healing in an experimental model
    R A Inglin
    Department of Visceral and Transplantation Surgery, Inselspital, University of Berne, CH 3010 Berne, Switzerland
    Br J Surg 95:793-8. 2008
    ..Mycophenolate mofetil (MMF) has been found to impair the healing of colonic anastomoses in rats. This study examined whether insulin-like growth factor (IGF) I prevents MMF impairment of anastomotic healing...
  84. ncbi The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats
    Andrew G Foley
    School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Neuropharmacology 54:1166-74. 2008
    ....
  85. pmc Capsaicin-induced neuronal death and proliferation of the primary sensory neurons located in the nodose ganglia of adult rats
    K Czaja
    Department of Veterinary, Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman, WA 99163 6520, USA
    Neuroscience 154:621-30. 2008
    ..The adult nodose ganglion, therefore, provides a novel system for studying neural plasticity and adult neurogenesis after peripheral injury of primary sensory neurons...
  86. ncbi Developmental exposure to 3,4-methylenedioxymethamphetamine results in downregulation of neurogenesis in the adult mouse hippocampus
    K O Cho
    Department of Pharmacology, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Socho gu, Seoul, 137 701, Korea
    Neuroscience 154:1034-41. 2008
    ..Our results suggest that developmental exposure to MDMA can result in decreases in the proliferation and survival of mature newborn cells in the adult dentate gyrus...
  87. ncbi The total flavonoids extracted from Xiaobuxin-Tang up-regulate the decreased hippocampal neurogenesis and neurotrophic molecules expression in chronically stressed rats
    Lei An
    Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
    Prog Neuropsychopharmacol Biol Psychiatry 32:1484-90. 2008
    ..o.) exerted same effects. In conclusion, the increase of neurogenesis, as well as expression of BDNF and pCREB in hippocampus may be one of the molecular and cellular mechanisms underlying the antidepressant action of XBXT-2...
  88. ncbi Electroacupuncture attenuates the decrease of hippocampal progenitor cell proliferation in the adult rats exposed to chronic unpredictable stress
    Qiong Liu
    Institute of Acupuncture Research WHO Collaborating Center for Traditional Medicine, Institutes of Brain Science, Fudan University, Shanghai 200032, China
    Life Sci 81:1489-95. 2007
    ..The study demonstrated a potential antidepressant-like effect of EA treatment on CUS induced depression model rats, which might be mediated by up-regulating the hippocampal progenitor cell proliferation...
  89. ncbi Hippocampal granule neuron production and population size are regulated by levels of bFGF
    Yinghong Cheng
    Department of Neuroscience and Cell Biology UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Eur J Neurosci 15:3-12. 2002
    ..P., Black, I.B. & DiCicco-Bloom, E. (1999) J. Neurosci., 19, 6006], these observations suggest distinct, stage-specific roles of bFGF in the dentate gyrus granule cell lineage...
  90. ncbi Intrathecal administration of epidermal growth factor and fibroblast growth factor 2 promotes ependymal proliferation and functional recovery after spinal cord injury in adult rats
    Atsuhiro Kojima
    Division of Neurosurgery, University of Toronto and Toronto Western Institute, Ontario, Canada
    J Neurotrauma 19:223-38. 2002
    ..The exact mechanism for improved functional recovery after EGF plus FGF2 is not known...
  91. ncbi Changes in skin during distraction osteogenesis of the tibia in Sprague-Dawley rats: verification of epidermal proliferation by immunohistochemical methods
    Hak Chang
    Department of Plastic and Reconstructive Surgery, Research Institute of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Jongno gu, Korea
    Scand J Plast Reconstr Surg Hand Surg 41:97-102. 2007
    ..Although the physical properties of the skin can accommodate a lengthened bone, our results suggest that distraction osteogenesis stimulates epidermal proliferation, which might lead to an increase in the amount of skin...
  92. ncbi NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus
    Juan Nacher
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neurobiol Aging 24:273-84. 2003
    ..Injection of the NMDA receptor antagonist to aged rats increases significantly the number of proliferating cells, new neurons and radial glia-like cells in the hippocampus...
  93. ncbi Granule neurons generated during development extend divergent axon collaterals to hippocampal area CA3
    Nicholas B Hastings
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    J Comp Neurol 452:324-33. 2002
    ..We conclude that a proportion of the hippocampal mossy fiber projection extends septotemporally divergent axon collaterals to hippocampal area CA3...
  94. ncbi Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus
    Mi Hyeon Jang
    Department of Physiology, College of Medicine, Kyung Hee University, 1 Hoigi dong, Dongdaemoon gu, Seoul 130 701
    Neuroreport 13:1509-13. 2002
    ....
  95. ncbi Traumatic brain injury induced cell proliferation in the adult mammalian central nervous system
    S Chirumamilla
    The Department of Pediatric Critical Care, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Neurotrauma 19:693-703. 2002
    ..Taken together, these experiments demonstrate the compensatory capacity of the adult brain to injury and should lead to a new generation of studies aimed at enhancing the neuronal proliferative response...
  96. ncbi Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus
    Owain W Howell
    Division of Clinical Neurosciences, University of Southampton, Room LD70, D Level, South Academic Block, Southampton General Hospital, Southampton SO16 6YD, UK
    Neurobiol Dis 26:174-88. 2007
    ..We confirm an effect on proliferation in the cSVZ/SCZ of Y(1) receptor(-/-) mice and demonstrate a significant reduction in basal and seizure-induced proliferation in the DG of NPY(-/-) mice...
  97. ncbi Cyclosporine affects the proliferation and differentiation of neural stem cells in culture
    Jiasong Guo
    Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Neuroreport 18:863-8. 2007
    ..Cyclosporine also affected the differentiation of neural stem cells, which mainly increased astrocyte genesis and decreased neuron differentiation...
  98. ncbi Migrating neuroblasts of the rostral migratory stream are putative targets for the action of nitric oxide
    María Gutierrez-Mecinas
    Departamento de Biologia Celular, Facultad de Ciencias Biologicas, Universidad de Valencia, Street Dr Moliner 50, E 46100 Burjasot, Spain
    Eur J Neurosci 26:392-402. 2007
    ..In turn, cGMP might induce the opening of cyclic nucleotide-gated ion channels, which are present in these cells...
  99. ncbi Acute alcohol intoxication decreases cell proliferation and nitric oxide synthase expression in dentate gyrus of rats
    Mi Hyeon Jang
    Department of Physiology, College of Medicine, Kyung Hee University, 1 Hoigi dong, Dongdaemun Gu, Seoul 130 701, South Korea
    Toxicol Lett 133:255-62. 2002
    ....
  100. ncbi Experience-dependent cell survival in the maternal rat brain
    Emis M Akbari
    Department of Psychology, University of Toronto at Mississauga, Mississauga, ON, Canada
    Behav Neurosci 121:1001-11. 2007
    ..The results suggest that early preweaning maternal isolation alters the structural plasticity that occurs following a postpartum maternal experience...
  101. ncbi Effects of Puerariae radix on cell proliferation and nitric oxide synthase expression in dentate gyrus of alcohol-intoxicated Sprague-Dawley rats
    Mi Hyeon Jang
    Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea
    Jpn J Pharmacol 88:355-8. 2002
    ..It is possible that nitric oxide, which might play an important role in the regulation of cell proliferation, is a major target of the toxic effects of alcohol...

Research Grants62

  1. Suppression of Ocular Scarring - Controlled Delivery of an ALK-5 Inhibitor
    Hiroshi Nakamura; Fiscal Year: 2013
    ..As subconjunctival anti-scarring treatments, antimetabolites, generally 5-fluorouracil (5-FU) and mitomycin-C (MMC), are commonly used to reduce post-operative scarring ..
  2. Validation and Development of WEE1 as a therapeutic target in AML
    Christopher C Porter; Fiscal Year: 2013
    ..survival, acting inS phase to ensure accurate DNA replication, and that combining inhibition of Wee1 with antimetabolites will be more effective in eliminating leukemia cells than antimetabolites alone...
  3. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2009
    ..Treatment of ALL requires a maintenance phase of approximately two years composed of oral administration of antimetabolites [6-Mercaptopurine (6MP) and methotrexate (MTX)] in order to achieve durable remissions...
  4. Alternative antiviral drug targets for human cytomegalovirus infection
    Sunwen Chou; Fiscal Year: 2013
    ..of cell culture conditions on in vitro maribavir susceptibility, and the synergistic effect of cellular antimetabolites, suggested that use of maribavir in combination with cellular kinase inhibitors may be beneficial...
  5. Pharmacogenetics of Tamoxifen and Chemotherapies and Risk of Contralateral Breast
    Jane C Figueiredo; Fiscal Year: 2010
    ..e., CYP3A5, GSTM1, GSTP1, GSTT1);anthracyclines (i.e., CYP3A5, MDR1, GSTM1, GSTP1, GSTT1) and antimetabolites (i.e., DHFR, TS, MTHFR) ...
  6. Mechanisms of Cytotoxicity and Radiosensitization for Antimetabolites
    Donna S Shewach; Fiscal Year: 2013
    ..We now propose that these mechanisms can be generalized to other antimetabolites that produce alterations in deoxynucleotide pools and function as radiosensitizers, such as hydroxyurea (..
  7. Pharmacogenomics of a Cytidine Analogue, Gemcitabine
    Liewei Wang; Fiscal Year: 2010
    ..Cancer Research training in pharmacogenomics -- with an emphasis on the pharmacogenomics of purine antimetabolites such as 6-mercaptopurine...
  8. Human Folylpolyglutamate Synthetase and Cancer Therapeutics
    Richard G Moran; Fiscal Year: 2013
    ..synthetase is an enzyme that metabolizes the naturally occurring folate cofactors and all classical folate antimetabolites to forms that contain 5-6 glutamic acid residues per molecule...
  9. First-line Antimetabolites as Steroid-sparing Treatment (FAST) Uveitis Trial
    Nisha Acharya; Fiscal Year: 2013
    ..These include the antimetabolites, calcineurin inhibitors, alkylating agents, and biologic drugs...
  10. ANTITUMOR DRUG EFFECTS ON PHOSPHATIDYLINOSITIDE TURNOVER
    JOHANNA STOECKLER; Fiscal Year: 1990
    ..b>Antimetabolites that deplete cellular GTP, i.e., selenazofurin and mycophenolic acid, or that form GTP analogs, i.e...
  11. Mechanisms of Sensitivity to Cell Cycle Checkpoint Kinase Inhibitors
    ALAN R EASTMAN; Fiscal Year: 2013
    ..Accordingly, Chk1 inhibitors can dramatically sensitize cells to antimetabolites such as hydroxyurea and gemcitabine...
  12. MOLECULAR MODE OF ACTION OF BACTERIAL ENTEROTOXINS
    JOHNNY PETERSON; Fiscal Year: 1999
    ..b>Antimetabolites (e.g., actinomycin D and cycloheximide) and nonsteroidal anti-inflammatory drugs (e.g...
  13. ANTIMETOBOLITES AND NUCLEAR MATRIX-BOUND DNA REPLICATION
    Daniel Fernandes; Fiscal Year: 1991
    ..Since many antimetabolites used in cancer chemotherapy induce strand-breaks, fragmentations, and other alterations in DNA, it seems ..
  14. MOLECULAR CORRELATES OF METHOTREXATE IN CHILDHOOD ALL
    Larry Matherly; Fiscal Year: 2007
    ..The focus is on methotrexate (MTX) and 6-mercaptopurine (6-MP), antimetabolites that continue to be cornerstones of modern treatment protocols for ALL, and on critical unanswered questions ..
  15. MECHANISMS OF ANTIFOLATE EFFICACY IN ARTHRITIS
    Sarah Morgan; Fiscal Year: 2000
    ..The information obtained from the proposed research will enhance the understanding of the biochemical action of antifolates/antimetabolites that are effective in the treatment of human and animal arthritis.
  16. HYDROXYUREA SYNERGY WITH OTHER ANTICANCER DRUGS IN VIVO
    William Vaughan; Fiscal Year: 1990
    ..potentiate the antineoplastic activity of several classes of antineoplastic drugs including other antimetabolites, alkylating agents, and drugs which intercalate DNA or interfere with topoisomerase II function...
  17. TRANSGLUTAMINASE INHIBITORS AND SOLID PHASE SUBSTRATES
    MARY TRAWICK; Fiscal Year: 1991
    ..active-site directed glutamine residues are replaced by residues that are glutamine analogs, derivatives, or antimetabolites. Selection of glutamine analogs is based on the results of inhibitor studies carried out in a model system ..
  18. HOST/TUMOR RESPONSE TO BUDR/IUDR ADMINISTRATION
    PHILIP STETSON; Fiscal Year: 1992
    ..that the unique approach taken in this proposal to evaluate host vs tumor response to administration of these antimetabolites, will provide the necessary insight into the biological variables pertinent to the efficient development of ..
  19. DEVELOPMENT OF A NOVEL GLAUCOMA IMPLANT
    Abdul Ahmed; Fiscal Year: 2004
    ..Although antimetabolites have improved success rates for trabeculectomy, their use is associated with unpredictable control of flow, ..
  20. Regulation of ATPase II and Clearance of Cancer Cells
    Probal Banerjee; Fiscal Year: 2004
    ..and test a novel strategy of removing cancer cells through phagocytosis without attempting to kill them with antimetabolites. In this strategy we will selectively ablate ATPase II expression in the cancer cells by using ATPase II-..
  21. MODULATION OF NUCLEOSIDE TRANSPORT IN CHEMOTHERAPY
    Judith Belt; Fiscal Year: 2000
    ..this project has been that selective chemotherapy using nucleoside transport inhibitors in combination with antimetabolites can be developed based on the nucleoside transport properties of the tumor and the dose-limiting normal ..
  22. Trabecular Bypass Stent and Applicator
    GREGORY SMEDLEY; Fiscal Year: 2002
    ..After failure of conservative therapy, trabeculectomy with or without antimetabolites is used to lower lop...
  23. Novel therapies for biliary cancers in BK5.erbB-2 mice
    John DiGiovanni; Fiscal Year: 2007
    ..synthesis in tumor cells which overexpress these genes, thereby increasing incorporation of clinically used antimetabolites. Our hypothesis is that inhibition of specific genes either at the DNA or protein level and/or induction of ..
  24. CLINICAL BIOCHEMICAL PHARMACOLOGY IN CANCER THERAPEUTICS
    Patrick Creaven; Fiscal Year: 1991
    ..Determinants of response to cytosine arabinoside (Ara-C) including high dose Ara- C and related antimetabolites will be evaluated in patients receiving this drug for the teatment of ANLL...
  25. Development of a micropump for the glaucomatous eye
    DAVID HAFFNER; Fiscal Year: 2005
    ..After failure of conservative therapy, trabeculectomy with or without antimetabolites is used to lower IOP...
  26. TRIPTYCENE ANALOGS--NOVEL BIFUNCTIONAL ANTICANCER DRUGS
    Jean Pierre Perchellet; Fiscal Year: 2004
    ..use of bifunctional TT2 analogs with antileukemic activity in the nM range in vitro might provide a considerable advantage in polychemotherapy to potentiate the action of antimetabolites and sensitize MDR tumor cells.
  27. Salvage Transporter as a Target for Drug Discovery
    Joanne Wang; Fiscal Year: 2004
    DESCRIPTION (provided by applicant) Antimetabolites targeting the key enzymes of purine de novo synthesis are important drugs used in cancer chemotherapy...
  28. Caudal Brain Stem Lactate Availability Regulates Feeding
    Karen Briski; Fiscal Year: 2004
    ..and hyperglycemia occur in response to fourth ventricular administration of glucose uptake inhibitors or antimetabolites. These findings suggest that decreased glucose oxidation (and consequent diminished generation of metabolic ..
  29. RATIONAL APPROACHES TO COMBINATION CHEMOTHERAPY
    ALEXANDER BLOCH; Fiscal Year: 1980
    ..induced perturbations in deoxyribonucleoside pools in determining the mechanism of action and interaction of antimetabolites; d) to evaluate the relationship between inbalances in the deoxynucleoside triphosphate pools and the ..
  30. Treatment of proliferative vitreoretinopathy by inhibition of migration
    Eugene Levin; Fiscal Year: 2009
    ..Attempts to treat PVR have involved the use of antimetabolites and steroids...
  31. Inhibition of Migration for PVR Treatment
    Eugene Levin; Fiscal Year: 2005
    ..Attempts to treat PVR have involved the use of antimetabolites and steroids...
  32. CORRELATIONS OF NEW AND OLD CELL KINETIC PARAMETERS
    Claudio Nicolini; Fiscal Year: 1980
    OBJECTIVES: By means of flow and static cytometry determine effects of other DNA antimetabolites (such as hydroxyurea) and antimitotic poisons (such as vincristine) on: a) the cell kinetics and the progression of cells through the cycle, ..
  33. Fatty Acid Synthase in Prostate Tumorigenesis
    BETH PFLUG; Fiscal Year: 2007
    ..Specific Aim 3. To determine the effects of FAS antimetabolites on inhibition of the development and metastatic spread of androgen-dependent and -independent prostate cancer ..
  34. PERCUTANEOUS ABSORPTION AND EFFECTS OF ANTIMETABOLITES
    JOSEPH WALTER; Fiscal Year: 1980
    ....
  35. INTERNATIONAL SYMPOSIUM ON POLYAMINES IN CANCER
    Kenji Nishioka; Fiscal Year: 1991
    ..in mammalian cells, polyamines in transformation, polyamines in carcinogenesis and chemoprevention, polyamine antimetabolites in vitro and in vivo tumor models, and clinical studies of polyamine antimetabolites in cancer...
  36. P-31 MRS: CHEMOTHERAPY RESPONSE PREDICTOR
    Jeffrey Evelhoch; Fiscal Year: 1991
    ..e., DNA-binder-intercalators, alkylating agents and antimetabolites) and a new antitumor agent of unknown mechanism will be identified by using sets of tumors that contain one ..
  37. Incorporation of microRNA expression in pharmacogenetic prediction models
    Rong Stephanie Huang; Fiscal Year: 2010
    ..we will focus on two classes of cytotoxic agents: platinating agents (cisplatin and carboplatin) and antimetabolites (capecitabine and Ara-C), of which significant inter-ethnic differences in cellular sensitivity have been ..
  38. EFFECTS OF ANTIMETABOLITES ON RNA METABOLISM
    BRUCE DOLNICK; Fiscal Year: 1992
    ..3. Study the effect of FUra pretreatment on methotrexate cytotoxicity in cells expressing mRNAs with altered 3' noncoding regions to correlate alterations in mRNA half life with DHFR drug responsiveness...
  39. Structure and Mechanism of Yeast Orotate PRTase
    RONALD MCCLARD; Fiscal Year: 2002
    ..In general, mechanistic/structural studies such as these, often offer a powerful means to the rational design of antimetabolites - perhaps anticancer agents.
  40. LIPOSOMES AS ARTIFICIAL VESICLES FOR DRUG DELIVERY
    ZOLTAN TOKES; Fiscal Year: 1980
    ..In addition, liposomes containing the active phosphorylated forms of antimetabolites are used in efforts to circumvent drug resistance resulting from diminished rates of intracellular ..
  41. HYPOXIC CELL SELECTIVE CHEMOTHERAPEUTIC AGENTS
    Alan Sartorelli; Fiscal Year: 1991
    ..agents of the quinone and nitroimidazole classes and hydroxylamino derivatives of purine and pyrimidine antimetabolites; (c) ascertain the cytotoxic properties of these agents toward neoplastic cell in vitro under both aerobic ..
  42. Protein interactions in purine synthesis
    TIMOTHY LANGSTON; Fiscal Year: 2007
    ..In the process of studying folate antimetabolites, this lab identified, characterized and purified the tri-functional enzyme...
  43. POLYAMINES, POLYAMINE ANTIMETABOLITES AND CELL GROWTH
    LAURENCE MARTON; Fiscal Year: 1980
    ..The effect of polyamine antimetabolites on cell cycle traverse will be studied also...
  44. DESIGN & SYNTHESIS OF DDATHF ANALOGS AS ANTITUMOR AGENT
    Edward Taylor; Fiscal Year: 1991
    This proposal describes a series of synthetic studies on deazatetrahydrofolates, a new class of folate antimetabolites which inhibit de novo purine biosynthesis and have shown extraordinarily potent and selective antitumor activity...
  45. THYMUS DNA POLYMERASE--ASSOCIATED REGULATORY PROTEIN
    Enrico Mihich; Fiscal Year: 1980
    ..the importance and function of this protein with respect to the relationship between deoxyribonucleoside triphosphate pools and DNA synthesis, the mechanism of action of antimetabolites and a potentially critical role in DNA replication.
  46. QUALITY OF LIFE AND COST EFFECTIVENESS IN CMV RETINITIS
    John Kempen; Fiscal Year: 2002
    ..Subanalyses will assess what factors other than treatment strategy are associated with improved QOL and cost-effectiveness. ..
  47. The Role of Acetylcholine Dysfunction in Diencephalic Amnesia
    Lisa M Savage; Fiscal Year: 2010
    ..Such experiments are critical to understanding the role of acetylcholine dysfunction in amnesia and thus the development of pharmacotherapeutics. ..
  48. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    LAURA NGWENYA; Fiscal Year: 2005
    ..It has been established that cognitive decline occurs with age. This proposed investigation will determine if there are changes in adult cell genesis that could be important in the neurobiological basis of age-related cognitive decline. ..
  49. Context Effects in De Novo Fear Conditioning in Humans
    Michael Otto; Fiscal Year: 2006
    ..abstract_text> ..
  50. Stress, Distress Intolerance, and Drug Dependence
    Michael Otto; Fiscal Year: 2008
    ..abstract_text> ..
  51. COGNITIVE ASSESSMENTS IN THE MOUSE
    Michela Gallagher; Fiscal Year: 2002
    ..The models will be developed using F1 hybrids of C57B/6 129svImJ mice and comparisons with the inbred parent strains will also be made. ..
  52. Apoptosis and Renewal of Neural Progenitor Cells
    Pasko Rakic; Fiscal Year: 2010
    ..These studies will enhance our understanding of neural plasticity and functional recovery after brain injury. ..
  53. Parental Expression of Immune Responses In Pediatric Crohn's Disease
    Marla Dubinsky; Fiscal Year: 2008
    ..unreadable] [unreadable]..