hexuronic acids

Summary

Summary: Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.

Top Publications

  1. pmc Proteolytic regulation of alginate overproduction in Pseudomonas aeruginosa
    F Heath Damron
    Department of Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, VA, USA
    Mol Microbiol 84:595-607. 2012
  2. pmc ClpXP proteases positively regulate alginate overexpression and mucoid conversion in Pseudomonas aeruginosa
    Dongru Qiu
    Department of Biochemistry and Microbiology, Joan C Edwards School of Medicine at Marshall University, Huntington, WV 25755 9320, USA
    Microbiology 154:2119-30. 2008
  3. pmc Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients
    D W Martin
    Department of Microbiology, University of Texas Health Science Center, San Antonio 78284 7758
    Proc Natl Acad Sci U S A 90:8377-81. 1993
  4. ncbi The second messenger bis-(3'-5')-cyclic-GMP and its PilZ domain-containing receptor Alg44 are required for alginate biosynthesis in Pseudomonas aeruginosa
    Massimo Merighi
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Mol Microbiol 65:876-95. 2007
  5. ncbi The exopolysaccharide alginate protects Pseudomonas aeruginosa biofilm bacteria from IFN-gamma-mediated macrophage killing
    Jeff G Leid
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA
    J Immunol 175:7512-8. 2005
  6. pmc Regulated proteolysis controls mucoid conversion in Pseudomonas aeruginosa
    Dongru Qiu
    Department of Biochemistry and Microbiology, Joan C Edwards School of Medicine, Marshall University, Huntington, WV 25755 9320, USA
    Proc Natl Acad Sci U S A 104:8107-12. 2007
  7. pmc Role of exopolysaccharides in Pseudomonas aeruginosa biofilm formation and architecture
    Aamir Ghafoor
    Institute of Molecular Biosciences, Massey University, Private Bag 11222, Palmerston North, New Zealand
    Appl Environ Microbiol 77:5238-46. 2011
  8. ncbi Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review
    Meera George
    Polymer Section, Chemical Science Division, Regional Research Laboratory CSIR, Trivandrum 695 019, India
    J Control Release 114:1-14. 2006
  9. pmc Identification of AlgR-regulated genes in Pseudomonas aeruginosa by use of microarray analysis
    Stephen E Lizewski
    Department of Microbiology and Immunology, Program in Molecular Pathogenesis and Immunity, Louisiana Center for Lung Biology and Immunotherapy, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112 2699, USA
    J Bacteriol 186:5672-84. 2004
  10. pmc MucR, a novel membrane-associated regulator of alginate biosynthesis in Pseudomonas aeruginosa
    Iain D Hay
    Institute of Molecular Biosciences, Massey University, Private Bag 11222, Palmerston North, New Zealand
    Appl Environ Microbiol 75:1110-20. 2009

Research Grants

  1. Application of alginate for endovascular embolization
    Timothy Becker; Fiscal Year: 2005
  2. Targeted Integration of Tissue Engineered Cartilage
    Jennifer Elisseeff; Fiscal Year: 2004
  3. 2005 Summer Bioengineering Conference
    Jennifer Wayne; Fiscal Year: 2005
  4. Cardiovascular Effects of lyengar Yoga
    Raymond Townsend; Fiscal Year: 2006
  5. Localized gene expression within P. aeruginosa biofilms
    Michael Franklin; Fiscal Year: 2006
  6. Islet Transplantation - Protection by Immunobarriers
    Gordon Weir; Fiscal Year: 2007
  7. Food Rheology and Feeding in Lean and Obese Humans
    Richard Mattes; Fiscal Year: 2007
  8. Role of OxyR in P. aeruginosa Biofilm Resistance to H202
    DANIEL HASSETT; Fiscal Year: 2007
  9. Application of ALGEL for embolization of aneurysms
    Timothy Becker; Fiscal Year: 2004
  10. In Vivo Survival of an Engineered Cartilage Construct
    Jennifer Wayne; Fiscal Year: 2004

Detail Information

Publications294 found, 100 shown here

  1. pmc Proteolytic regulation of alginate overproduction in Pseudomonas aeruginosa
    F Heath Damron
    Department of Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, VA, USA
    Mol Microbiol 84:595-607. 2012
    ..aeruginosa to respond to environmental stress conditions by overproduction of alginate. The goal of this review is to illuminate the pathways leading to RIP that have been identified and proposed...
  2. pmc ClpXP proteases positively regulate alginate overexpression and mucoid conversion in Pseudomonas aeruginosa
    Dongru Qiu
    Department of Biochemistry and Microbiology, Joan C Edwards School of Medicine at Marshall University, Huntington, WV 25755 9320, USA
    Microbiology 154:2119-30. 2008
    ..The ClpXP and ClpP2 proteins appear to be part of a proteolytic network that degrades the cytoplasmic portion of truncated MucA proteins to release the sequestered AlgU, which drives alginate biosynthesis...
  3. pmc Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients
    D W Martin
    Department of Microbiology, University of Texas Health Science Center, San Antonio 78284 7758
    Proc Natl Acad Sci U S A 90:8377-81. 1993
    ....
  4. ncbi The second messenger bis-(3'-5')-cyclic-GMP and its PilZ domain-containing receptor Alg44 are required for alginate biosynthesis in Pseudomonas aeruginosa
    Massimo Merighi
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Mol Microbiol 65:876-95. 2007
    ..Alg44 appears to be an essential component of the alginate biosynthetic apparatus, where, following binding of c-di-GMP, it controls polymerization or transport of the polysaccharide...
  5. ncbi The exopolysaccharide alginate protects Pseudomonas aeruginosa biofilm bacteria from IFN-gamma-mediated macrophage killing
    Jeff G Leid
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA
    J Immunol 175:7512-8. 2005
    ..aeruginosa biofilm bacteria from the human immune system...
  6. pmc Regulated proteolysis controls mucoid conversion in Pseudomonas aeruginosa
    Dongru Qiu
    Department of Biochemistry and Microbiology, Joan C Edwards School of Medicine, Marshall University, Huntington, WV 25755 9320, USA
    Proc Natl Acad Sci U S A 104:8107-12. 2007
    ..These results suggest that AlgU is regulated similarly to E. coli sigma(E) except that the amino acid triad signals from MucE and other envelope proteins that activate AlgW are slightly different from those activating DegS...
  7. pmc Role of exopolysaccharides in Pseudomonas aeruginosa biofilm formation and architecture
    Aamir Ghafoor
    Institute of Molecular Biosciences, Massey University, Private Bag 11222, Palmerston North, New Zealand
    Appl Environ Microbiol 77:5238-46. 2011
    ..Overall, this study demonstrated that the various exopolysaccharides and eDNA interactively contribute to the biofilm architecture of P. aeruginosa...
  8. ncbi Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review
    Meera George
    Polymer Section, Chemical Science Division, Regional Research Laboratory CSIR, Trivandrum 695 019, India
    J Control Release 114:1-14. 2006
    ..The favourable properties like biocompatibility, biodegradability, pH sensitiveness, mucoadhesiveness, etc. has enabled these polymers to become the choice of the pharmacologists as oral delivery matrices for proteins...
  9. pmc Identification of AlgR-regulated genes in Pseudomonas aeruginosa by use of microarray analysis
    Stephen E Lizewski
    Department of Microbiology and Immunology, Program in Molecular Pathogenesis and Immunity, Louisiana Center for Lung Biology and Immunotherapy, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112 2699, USA
    J Bacteriol 186:5672-84. 2004
    ....
  10. pmc MucR, a novel membrane-associated regulator of alginate biosynthesis in Pseudomonas aeruginosa
    Iain D Hay
    Institute of Molecular Biosciences, Massey University, Private Bag 11222, Palmerston North, New Zealand
    Appl Environ Microbiol 75:1110-20. 2009
    ..Overall, experimental evidence was provided suggesting that MucR specifically regulates alginate biosynthesis by activation of alginate production through generation of a localized c-di-GMP pool in the vicinity of Alg44...
  11. ncbi Cell wall-inhibitory antibiotics activate the alginate biosynthesis operon in Pseudomonas aeruginosa: Roles of sigma (AlgT) and the AlgW and Prc proteases
    Lynn F Wood
    Department of Microbiology and Immunology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA 23298 0678, USA
    Mol Microbiol 62:412-26. 2006
    ..In addition, a mutation in gene PA3257 (prc), encoding a Prc-like protease, resulted in poor induction of PalgD-cat by D-cycloserine, suggesting that it also plays a role in the response to cell wall stress...
  12. ncbi Alginate hydrogels as biomaterials
    Alexander D Augst
    Division of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA
    Macromol Biosci 6:623-33. 2006
    ..Micro-CT images of bone-like constructs that result from transplantation of osteoblasts on gels that degrade over a time frame of several months leading to improved bone formation...
  13. ncbi Multiscale requirements for bioencapsulation in medicine and biotechnology
    Paul De Vos
    University Hospital Groningen, Section of Medical Biology, Transplantation Biology and Immunoendocrinology, Hanzeplein 1, 9700RB Groningen, The Netherlands
    Biomaterials 30:2559-70. 2009
    ..For adequate reproducibility and for understanding variations in outcome of biocapsules it is advisable if not mandatory to include the characterization processes presented in this review in future studies...
  14. ncbi Chitosan-sodium alginate nanoparticles as submicroscopic reservoirs for ocular delivery: formulation, optimisation and in vitro characterisation
    Sanjay K Motwani
    Department of Pharmaceutics, New Delhi, India
    Eur J Pharm Biopharm 68:513-25. 2008
    ..Box-Behnken experimental design thus facilitated the optimisation of mucoadhesive nanoparticulate carrier systems for prolonged ocular delivery of the drug...
  15. ncbi Different mutations in mucA gene of Pseudomonas aeruginosa mucoid strains in cystic fibrosis patients and their effect on algU gene expression
    Giovanna Pulcrano
    Department of Molecular and Cellular Biology and Pathology, University of Naples, Federico II, Naples, Italy
    New Microbiol 35:295-305. 2012
    ..Analysis of algU expression disclosed that the length significantly affects the expression of genes involved in the production of alginate and in the motility and hence survival of P. aeruginosa strains in cystic fibrosis lungs...
  16. ncbi Characterisation of freeze-dried wafers and solvent evaporated films as potential drug delivery systems to mucosal surfaces
    Joshua S Boateng
    Department of Pharmaceutical Sciences, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, John Arbuthnott Building, 27 Taylor Street, Glasgow G4 0NR, UK
    Int J Pharm 389:24-31. 2010
    ....
  17. ncbi Poly-L-Lysine induces fibrosis on alginate microcapsules via the induction of cytokines
    B L Strand
    Department of Biotechnology, Norwegian University of Science and Technology, Trondheim
    Cell Transplant 10:263-75. 2001
    ..By combining soluble PLL and alginate both the toxic and TNF-inducing effects of PLL were reduced. The implications of these data are to use alginate microcapsules with low amounts of PLL for transplantation purposes...
  18. pmc Characterization of a locus determining the mucoid status of Pseudomonas aeruginosa: AlgU shows sequence similarities with a Bacillus sigma factor
    D W Martin
    Department of Microbiology, University of Texas Health Science Center, San Antonio 78284 7758
    J Bacteriol 175:1153-64. 1993
    ....
  19. ncbi Pseudomonas aeruginosa AlgZ, a ribbon-helix-helix DNA-binding protein, is essential for alginate synthesis and algD transcriptional activation
    P J Baynham
    Department of Microbiology and Immunology, Medical Center Boulevard, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mol Microbiol 33:1069-80. 1999
    ..The cloning of algZ is a crucial step in determining the mechanism of algD activation...
  20. pmc Lipotoxin F of Pseudomonas aeruginosa is an AlgU-dependent and alginate-independent outer membrane protein involved in resistance to oxidative stress and adhesion to A549 human lung epithelia
    F Heath Damron
    Department of Biochemistry and Microbiology, Marshall University, Huntington, WV 25755 9320, USA
    Microbiology 155:1028-38. 2009
    ..LptF also contributed to adhesion to A549 human lung epithelial cells. Our data suggest that LptF is an outer membrane protein that may be important for P. aeruginosa survival in harsh environments, including lung colonization in CF...
  21. ncbi Mass transfers in a fluidized bed bioreactor using alginate beads for a future bioartificial liver
    B David
    Universite de Technologie de Compiegne, Laboratoire de Biomécanique et génie Biomédical, Compiegne, France
    Int J Artif Organs 27:284-93. 2004
    ..The shear enhanced diffusion coefficient for VitB12 was 20 times higher in the fluidized bed bioreactor than under batch conditions, proving the efficiency of such a device...
  22. ncbi Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin
    Biji Balakrishnan
    Division of Polymer Chemistry, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Satelmond Palace Campus, Trivandrum, Kerala 695 012, India
    Biomaterials 26:6335-42. 2005
    ..These in situ forming hydrogels fulfil many critical elements desirable in a wound dressing material...
  23. ncbi Sustained function of alginate-encapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient
    D Jacobs-Tulleneers-Thevissen
    Diabetes Research Center, Brussels Free University, Laarbeeklaan 103, 1090, Brussels, Belgium
    Diabetologia 56:1605-14. 2013
    ..This study examined in immunodeficient mice whether alginate-encapsulated graft function was inferior to that of free grafts of the same size and composition...
  24. ncbi Physicochemical model of alginate-poly-L-lysine microcapsules defined at the micrometric/nanometric scale using ATR-FTIR, XPS, and ToF-SIMS
    Susan K Tam
    Groupe de Recherche en Biomatériaux Biomécanique, Ecole Polytechnique de Montreal, C P 6079, Succ Centre Ville, Que, Canada
    Biomaterials 26:6950-61. 2005
    ..This physicochemical model of APA microcapsules could explain their immunogenicity and will play an important role in the optimization of the microcapsule design...
  25. ncbi Alginate-encapsulated HepG2 cells in a fluidized bed bioreactor maintain function in human liver failure plasma
    Sam M Coward
    Centre for Hepatology, Royal Free Hospital and UCL Medical School, London, UK
    Artif Organs 33:1117-26. 2009
    ....
  26. ncbi Perfusion of 3D encapsulated hepatocytes--a synergistic effect enhancing long-term functionality in bioreactors
    Rui M Tostões
    Animal Cell Technology Laboratory, IBET ITQB UNL, Oeiras, Portugal
    Biotechnol Bioeng 108:41-9. 2011
    ....
  27. ncbi Characterization of copper adsorption onto an alginate encapsulated magnetic sorbent by a combined FT-IR, XPS, and mathematical modeling study
    Soh Fong Lim
    Division of Environmental Science and Engineering, Department of Chemical and Biomolecular Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore
    Environ Sci Technol 42:2551-6. 2008
    ..The model is capable of describing and predicting effects of various key operational parameters on the adsorption process, such as initial pH, metal concentration, and dosage of sorbent...
  28. pmc Co-regulation of {beta}-lactam resistance, alginate production and quorum sensing in Pseudomonas aeruginosa
    Deepak Balasubramanian
    Department of Biological Sciences, College of Arts and Science, Florida International University, Miami, FL 33199, USA
    J Med Microbiol 60:147-56. 2011
    ....
  29. pmc Chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells in self-gelling alginate discs reveals novel chondrogenic signature gene clusters
    Sarah Roxana Herlofsen
    Norwegian Center for Stem Cell Research, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway
    Tissue Eng Part A 17:1003-13. 2011
    ..Analysis of the signature chondrogenic clusters, including novel potential marker genes identified here, may provide a better understanding of how the stem cell fate could be directed to produce perfect hyaline cartilage implants...
  30. ncbi Alginate-based microcapsules for immunoisolation of pancreatic islets
    Paul De Vos
    Department of Pathology and Laboratory Medicine, Division of Medical Biology, University Hospital of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Biomaterials 27:5603-17. 2006
    ..New approaches in which newly discovered inflammatory responses are silenced bring the technology of transplantation of immunoisolated cells close to clinical application...
  31. ncbi Enhancing the vascularization of three-dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheres
    Anat Perets
    Department of Biomedical Engineering, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Biomed Mater Res A 65:489-97. 2003
    ..The control over bFGF delivery and localizing its effects to areas of need, may aid in the wider application of bFGF in therapeutic angiogenesis as well as in tissue engineering...
  32. pmc The Pseudomonas aeruginosa sensor kinase KinB negatively controls alginate production through AlgW-dependent MucA proteolysis
    F Heath Damron
    Department of Biochemistry, Joan C Edwards School of Medicine at Marshall University, Huntington, West Virginia 25755 9320, USA
    J Bacteriol 191:2285-95. 2009
    ..Our results also indicate that AlgW-mediated MucA degradation required algB and rpoN in the kinB mutant. Collectively, these studies indicate that KinB is a negative regulator of alginate production in wt mucA strain PAO1...
  33. ncbi Enhanced antiproliferative activity of carboplatin-loaded chitosan-alginate nanoparticles in a retinoblastoma cell line
    Suphiya Parveen
    Laboratory of Nanomedicine, Institute of Life Sciences, Nalco Square, Chandrasekharpur, Bhubaneswar 751 023, Orissa, India
    Acta Biomater 6:3120-31. 2010
    ..In conclusion, biodegradable chitosan nanoparticles could be used as an effective ocular drug delivery system for sustained intracellular delivery of carboplatin for the treatment of retinoblastoma...
  34. ncbi Local endostatin treatment of gliomas administered by microencapsulated producer cells
    T A Read
    Department of Anatomy and Cell Biology, University of Bergen, Norway
    Nat Biotechnol 19:29-34. 2001
    ..The present work may thus provide the basis for new therapeutic approaches toward brain tumors...
  35. ncbi Effect of injectable alginate implant on cardiac remodeling and function after recent and old infarcts in rat
    Natali Landa
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer 52621, Israel
    Circulation 117:1388-96. 2008
    ..We hypothesized that injection of in situ-forming alginate hydrogel into recent and old infarcts would provide a temporary scaffold and attenuate adverse cardiac remodeling and dysfunction...
  36. ncbi Alginate production affects Pseudomonas aeruginosa biofilm development and architecture, but is not essential for biofilm formation
    Andres Plata Stapper
    Department of Biological Sciences, Florida International University, Miami, FL 33199, USA
    J Med Microbiol 53:679-90. 2004
    ..Furthermore, this study showed that phenotypically distinguishable biofilms can be quantitatively differentiated...
  37. pmc Regulation of mouse follicle development by follicle-stimulating hormone in a three-dimensional in vitro culture system is dependent on follicle stage and dose
    Pamela K Kreeger
    Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Biol Reprod 73:942-50. 2005
    ..The culture system can be adapted to each stage of development, which will be especially critical for translation to human follicles that have a longer developmental period...
  38. pmc The quest for targeted delivery in colon cancer: mucoadhesive valdecoxib microspheres
    Naveen K Thakral
    Centre for Biomedical Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, India
    Int J Nanomedicine 6:1057-68. 2011
    ..4 across Caco-2 cell monolayers were conducted. The microspheres were found to exhibit slower and delayed drug release and lower intracellular concentration of valdecoxib...
  39. ncbi Chitosan-alginate multilayer beads for controlled release of ampicillin
    Anil K Anal
    Bioprocess Technology Program, Asian Institute of Technology, Klong Luang, Bangkok 12120, Thailand
    Int J Pharm 290:45-54. 2005
    ..It is concluded that chitosan-alginate multilayer beads, cross-linked with polyphosphate offer an opportunity for controlled gastrointestinal passage of compounds with low molecular weight like ampicillin...
  40. ncbi Preparation of coated nanoparticles for a new mucosal vaccine delivery system
    Olga Borges
    Leiden Amsterdam Center for Drug Research, Division of Pharmaceutical Technology, P O Box 9502, 2300 RA Leiden, The Netherlands
    Int J Pharm 299:155-66. 2005
    ..The optimisation of the coating process resulted in 35% (w/w) for the loading capacity of the coated particles. SEM investigations confirmed a suitable size of the coated nanoparticles for the uptake by M-cells...
  41. ncbi Identification of a periplasmic AlgK-AlgX-MucD multiprotein complex in Pseudomonas aeruginosa involved in biosynthesis and regulation of alginate
    Iain David Hay
    Institute of Molecular Biosciences, Massey University, Palmerston North, New Zealand
    Appl Microbiol Biotechnol 93:215-27. 2012
    ..Overall, this study provided experimental evidence for the proposed periplasmic multiprotein complex and established a link of a constituent of this complex, MucD, to transcriptional regulation of alginate biosynthesis genes...
  42. ncbi Hollow chitosan-alginate multilayer microcapsules as drug delivery vehicle: doxorubicin loading and in vitro and in vivo studies
    Qinghe Zhao
    Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China
    Nanomedicine 3:63-74. 2007
    ..The results showed that the encapsulated DOX had better efficacy than that of the free drug in terms of tumor inhibition in a 4-week in vivo culture period...
  43. ncbi Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces
    Joshua S Boateng
    Department of Pharmaceutical Sciences, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Drug Dev Ind Pharm 35:986-96. 2009
    ..CMC films prepared at 45 degrees C and 6% RH produced suitable films at the fastest rate while films containing equal quantities of glycerol and CMC possessed an ideal balance between flexibility and rigidity...
  44. ncbi A novel system for three-pulse drug release based on "tablets in capsule" device
    Bin Li
    Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210038, PR China
    Int J Pharm 352:159-64. 2008
    ..However, lactose favored it. The results reveal that programmed drug delivery to achieve pulsatile drug release for three times daily can be obtained from these tablets in capsule system by systemic formulation approach...
  45. ncbi Injectable bone using chitosan-alginate gel/mesenchymal stem cells/BMP-2 composites
    Dong Joon Park
    Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, South Korea
    J Craniomaxillofac Surg 33:50-4. 2005
    ..This study was performed to investigate whether or not chitosan-alginate gel/mesenchymal stem cells/bone morphogenetic protein-2 composites are potentially injectable materials for new bone formation...
  46. pmc Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis
    Nadine Hoffmann
    Department of Bacteriology, Institute for Medical Microbiology and Immunology, Panum Institute, University of Copenhagen, Copenhagen DK 2200, Denmark
    Infect Immun 73:2504-14. 2005
    ..Therefore, the mouse model provides an improved method for evaluating the interaction between mucoid P. aeruginosa, the host, and antibacterial therapy...
  47. ncbi Preparation and evaluation of alginate-chitosan microspheres for oral delivery of insulin
    Yueling Zhang
    National Key Lab of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, PR China
    Eur J Pharm Biopharm 77:11-9. 2011
    ..Therefore, the alginate-chitosan microspheres were found to be promising vectors showing a good efficiency in oral administration of protein or peptide drugs...
  48. ncbi Molecular characterization of Alg8, a putative glycosyltransferase, involved in alginate polymerisation
    Uwe Remminghorst
    Institute of Molecular Biosciences, Massey University, Private Bag 11222, Palmerston North, New Zealand
    J Biotechnol 140:176-83. 2009
    ..The role of these amino acid residues with respect to the catalysed alginate polymerisation reaction was discussed with the aid of the recently developed structural model of Alg8...
  49. ncbi Drug carrier systems based on collagen-alginate composite structures for improving the performance of GDNF-secreting HEK293 cells
    M Lee
    Medical Engineering Program, Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region, China
    Biomaterials 30:1214-21. 2009
    ..This study contributes towards the development of cell-based GDNF delivery devices for the future therapeutics of neurodegenerative diseases...
  50. ncbi Manipulating the molecular weight of alginate produced by Azotobacter vinelandii in continuous cultures
    Alvaro Díaz-Barrera
    Escuela de Ingeniería Bioquímica, Pontificia Universidad Cato lica de Valparaíso, Av Brasil 2147, Casilla 4059, Valparaiso, Chile
    Bioresour Technol 101:9405-8. 2010
    ..42 g g(-1) h(-1). The manipulation of the D can be used to select the molecular weight of alginate in continuous culture...
  51. ncbi Follicle-like model by granulosa cell encapsulation in a barium alginate-protamine membrane
    D Vigo
    Dipartimento di Scienze e Tecnologie Veterinarie per la Sicurezza Alimentare, Milan, Italy
    Tissue Eng 11:709-14. 2005
    ..The encapsulated 3D culture system appears to be a promising way of obtaining in vitro maturation and development of follicles and oocytes...
  52. pmc Vanadate and triclosan synergistically induce alginate production by Pseudomonas aeruginosa strain PAO1
    F Heath Damron
    Department of Biochemistry and Microbiology, Joan C Edwards School of Medicine at Marshall University, Huntington, WV 25755 9320, USA
    Mol Microbiol 81:554-70. 2011
    ..Altogether, these findings suggest a model of alginate induction and the PIA-AMV medium may be suitable for examining early lung colonization phenotypes in CF before the selection of the mucA mutants...
  53. ncbi Alginate microsphere-collagen composite hydrogel for ocular drug delivery and implantation
    Wenguang Liu
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada, K1H8M5
    J Mater Sci Mater Med 19:3365-71. 2008
    ....
  54. ncbi Layer by layer chitosan/alginate coatings on poly(lactide-co-glycolide) nanoparticles for antifouling protection and Folic acid binding to achieve selective cell targeting
    Jie Zhou
    Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
    J Colloid Interface Sci 345:241-7. 2010
    ..For the HepG2 cell line significantly less uptake of PLGA NPs coated with Chi/Alg than the bare NPs was observed but the uptake increased after attachment of FA molecules...
  55. ncbi Superior cell delivery features of poly(ethylene glycol) incorporated alginate, chitosan, and poly-L-lysine microcapsules
    Tasima Haque
    Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, Quebec H3A 2B4, Canada
    Mol Pharm 2:29-36. 2005
    ..The study revealed the potential of using PEG-incorporated alginate, chitosan, and PLL microcapsules for encapsulating live cells producing proteins and hormones for therapy...
  56. pmc In vitro release kinetics and bioavailability of gastroretentive cinnarizine hydrochloride tablet
    Ramesh C Nagarwal
    Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India
    AAPS PharmSciTech 11:294-303. 2010
    ..Batch no. HP1 of floating tablet in rabbits demonstrated that the floating tablet CNZ could be a 24-h sustained release formulation...
  57. ncbi An appropriate selection of a 3D alginate culture model for hepatic Huh-7 cell line encapsulation intended for viral studies
    Nhu Mai Tran
    Biomechanics and Bioengineering, Unité Mixte de Recherche CNRS 7338, University of Technology of Compiegne, Compiegne, France
    Tissue Eng Part A 19:103-13. 2013
    ....
  58. ncbi Cell response to the exposure to chitosan-TPP//alginate nanogels
    Catherine A Schütz
    Institut d Ingénierie Biologique et Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Federale de Lausanne, EPFL SV IBI LMRP, Station 15, CH 1015, Lausanne, Switzerland
    Biomacromolecules 12:4153-61. 2011
    ..The results identify fungal chitosan as an alternative to animal chitosan in particular if biomedical/pharmaceutical applications are intended...
  59. ncbi Alginate-encapsulated human hepatoblastoma cells in an extracorporeal perfusion system improve some systemic parameters of liver failure in a xenogeneic model
    Tony M Rahman
    Center for Hepatology, Royal Free and University College Medical School, London, UK
    Artif Organs 28:476-82. 2004
    ..Such encapsulated cells have the potential to be developed for extracorporeal liver support systems for acute liver failure...
  60. pmc Functional characterization of AlgL, an alginate lyase from Pseudomonas aeruginosa
    Emma K Farrell
    Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
    Biochemistry 51:10259-66. 2012
    ..Rapid-mixing chemical quench studies revealed that there was no lag in dimer or trimer production, indicating that AlgL operates as an exopolysaccharide lyase...
  61. ncbi A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and algT/U activity results in the loss of alginate production
    Robert Sautter
    Department of Biological Sciences, College of Arts and Sciences, Florida International University, Miami, FL 33199, USA
    Gene 498:242-53. 2012
    ..PA3257 encodes a putative periplasmic protease. Mutation of PA3257 resulted in decreased algT/U expression. Thus, inhibition of algT/U is a primary mechanism for alginate synthesis suppression...
  62. ncbi Microencapsulation peptide and protein drugs delivery system
    Chuanyun Dai
    Key Laboratory of Biomechanics and Tissue Engineering under the State Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR China
    Colloids Surf B Biointerfaces 41:117-20. 2005
    ..Then discusses how these advances may be applied to resolve the challenges face the development of microcapsule for the controllable delivery of protein drugs...
  63. ncbi Evaluation of various parameters of calcium-alginate immobilization method for enhanced alkaline protease production by Bacillus licheniformis NCIM-2042 using statistical methods
    Ravichandra Potumarthi
    Bioengineering and Environmental Centre, Indian Institute of Chemical Technology CSIR, Tarnaka, Hyderabad, India
    Bioresour Technol 99:1776-86. 2008
    ..Cross-sectional scanning electron microscope images have shown the growth pattern of B. licheniformis in Ca-alginate immobilized beads...
  64. ncbi Alginate acetylation influences initial surface colonization by mucoid Pseudomonas aeruginosa
    Petra Tielen
    Department of Aquatic Microbiology, Biofilm Centre, University of Duisburg Essen, Geibelstrasse 41, 47057 Duisburg, Germany
    Microbiol Res 160:165-76. 2005
    ..aeruginosa, thereby determining the architecture of the mature biofilm...
  65. pmc Purification and characterization of phosphomannomutase/phosphoglucomutase from Pseudomonas aeruginosa involved in biosynthesis of both alginate and lipopolysaccharide
    R W Ye
    Department of Microbiology and Immunology, University of Illinois, College of Medicine, Chicago 60612
    J Bacteriol 176:4851-7. 1994
    ..This evidence suggests that AlgC functions as PMM and PGM in vivo, converting phosphomannose and phosphoglucose in the biosynthesis of both alginate and LPS...
  66. pmc The NtrC family regulator AlgB, which controls alginate biosynthesis in mucoid Pseudomonas aeruginosa, binds directly to the algD promoter
    Andrew J Leech
    Department of Microbiology and Immunology, P O Box 980678, Medical College of Virginia Campus of Virginia Commonwealth University, 1101 E Marshall St, 5 047 Sanger Hall, Richmond, VA 23298 0678, USA
    J Bacteriol 190:581-9. 2008
    ..Thus, AlgB belongs to a subclass of NtrC family proteins that can activate promoters which utilize a sigma factor other than sigma(54), in this case to stimulate transcription from the sigma(22)-dependent PalgD promoter...
  67. ncbi Alginate/chitosan particulate systems for sodium diclofenac release
    M L González-Rodríguez
    Departamento de Farmacia y Tecnología Farmacacéutica, Facultad de Farmacia, C Profesor Garcia Gonzalez s n, Universidad de Sevilla, 41012, Sevilla, Spain
    Int J Pharm 232:225-34. 2002
    ..4 and 7.2. The alginate/chitosan ratio and the nature of the gelifying cation allow a control of the release rate of the drug. The release mechanism was briefly discussed...
  68. ncbi pH sensitive alginate-guar gum hydrogel for the controlled delivery of protein drugs
    M George
    Polymer Section, Chemical Science Division, Regional Research Laboratory CSIR, Trivandrum 19, Trivandrum 695 019, India
    Int J Pharm 335:123-9. 2007
    ..4. Presence of guar gum and glutaraldehyde crosslinking increases entrapment efficiency and prevents the rapid dissolution of alginate in higher pH of the intestine, ensuring a controlled release of the entrapped drug...
  69. ncbi Alginate-folic acid-modified chitosan nanoparticles for photodynamic detection of intestinal neoplasms
    Shu Jyuan Yang
    Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 10051, Taiwan
    Biomaterials 32:2174-82. 2011
    ..These studies demonstrate that the alginate incorporated and folic acid-conjugated chitosan nanoparticles are excellent vectors for colorectal-specific delivery of 5-ALA for fluorescent endoscopic detection...
  70. pmc Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function
    M Hentzer
    Department of Microbiology, Technical University of Denmark, 2800 Lyngby, Denmark
    J Bacteriol 183:5395-401. 2001
    ..These results suggest that an important consequence of the conversion to mucoidy is an altered biofilm architecture that shows increasing resistance to antimicrobial treatments...
  71. ncbi Biocompatibility and physicochemical characteristics of alginate-polycation microcapsules
    S K Tam
    Laboratoire d innovation et d analyse de bioperformance, Institut de Génie Biomédical, Ecole Polytechnique, Montreal, Quebec, Canada
    Acta Biomater 7:1683-92. 2011
    ..Thus, alginate-polycation interactions for membrane formation are more important for biocompatibility than either the quantity of polycation at the surface or the alginate coating...
  72. ncbi Alginate/poly (lactic-co-glycolic acid)/calcium phosphate cement scaffold with oriented pore structure for bone tissue engineering
    Xiaopeng Qi
    Key Laboratory of Specially Functional Materials, Ministry of Education, South China University of Technology, Guangzhou 510641, China
    J Biomed Mater Res A 89:980-7. 2009
    ..Alginate/PLGA/CPC scaffold preserved the open directional macropores and might be a potential scaffold for bone tissue engineering...
  73. ncbi Inhibition of in vitro chondrogenesis in RGD-modified three-dimensional alginate gels
    John T Connelly
    George W Woodruff School of Mechanical Engineering, Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332, USA
    Biomaterials 28:1071-83. 2007
    ..These results provide new insights into the role of cell-matrix interactions in regulating chondrogenesis and highlight the importance of choosing appropriate biomaterials for tissue engineering therapies...
  74. pmc Microencapsulation of islets within alginate/poly(ethylene glycol) gels cross-linked via Staudinger ligation
    K K Hall
    Department of Biomedical Engineering, College of Engineering, University of Miami, 1450 NW 10th Avenue, Miami, FL 33136, USA
    Acta Biomater 7:614-24. 2011
    ..The remarkable improved stability, as well as demonstrated cellular compatibility, of XAlgPEG hydrogels makes them an appealing option for a wide variety of tissue engineering applications...
  75. ncbi Alginate-based encapsulation of cells: past, present, and future
    Heiko Zimmermann
    Lehrstuhl fur Biotechnologie, Biozentrum, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Curr Diab Rep 7:314-20. 2007
    ..Focus on the development of good manufacturing practice-conforming microfluidic chip technology for generation of immunoisolated transplants and on cryopreservation technology will bring the cell-based therapy to the market and clinics...
  76. ncbi Delivery of neurotrophin-3 to the cochlea using alginate beads
    Farnoosh Noushi
    University of Melbourne, Department of Otolaryngology, East Melbourne, Australia
    Otol Neurotol 26:528-33. 2005
    ..The aim of this study was to design a novel cochlear neurotrophin (NT) delivery system for the rescue of auditory neurons after ototoxicity-induced deafening...
  77. ncbi Physical and biological properties of barium cross-linked alginate membranes
    Heiko Zimmermann
    Abteilung Kryobiophysik and Kryotechnologie, Fraunhofer Institut für Biomedizinische Technik, D 66386 St Ingbert, Germany
    Biomaterials 28:1327-45. 2007
    ..Murine L929 cells adhere strongly to the rough surface of crystal-bombarded membranes. NaCl-mediated membrane swelling can be prevented by partial replacement of salt with sorbitol allowing cell culture on the membranes...
  78. ncbi Alg44, a unique protein required for alginate biosynthesis in Pseudomonas aeruginosa
    Uwe Remminghorst
    Institute of Molecular Biosciences, Massey University, Private Bag 11222, Palmerston North, New Zealand
    FEBS Lett 580:3883-8. 2006
    ..The corresponding 42.6 kDa protein was purified and identified by MALDI/TOF-MS analysis. Alg44 might be directly involved in alginate polymerization presumably by exerting a regulatory function...
  79. ncbi Human hepatocyte cell lines proliferating as cohesive spheroid colonies in alginate markedly upregulate both synthetic and detoxificatory liver function
    M Khalil
    Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    J Hepatol 34:68-77. 2001
    ..CONCLUSION: Hepatocyte cell-lines, proliferating in alginate express a range of liver-specific functions at levels approaching those found in vivo, relevant to their use in liver support systems...
  80. ncbi Alginate/chitosan nanoparticles are effective for oral insulin delivery
    B Sarmento
    Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha 164, 4050 047, Porto, Portugal
    Pharm Res 24:2198-206. 2007
    ..To evaluate the pharmacological activity of insulin-loaded alginate/chitosan nanoparticles following oral dosage in diabetic rats...
  81. ncbi Effects of alginate inclusion on the vector properties of chitosan-based nanoparticles
    Kimberly L Douglas
    Department of Biomedical Engineering, McGill University, 3775 University St, Montreal, QC, Canada H3A 2B4
    J Control Release 115:354-61. 2006
    ..Overall, alginate inclusion improved the vector properties of chitosan-based nanoparticles, demonstrating superior transfection ability while maintaining biocompatibility and low toxicity...
  82. ncbi The effect of injected RGD modified alginate on angiogenesis and left ventricular function in a chronic rat infarct model
    Jiashing Yu
    University of California Berkeley and University of California San Francisco Joint Bioengineering Graduate Group, Berkeley San Francisco, CA, United States
    Biomaterials 30:751-6. 2009
    ..These results suggest that in situ use of modified polymers may influence the tissue microenvironment and serve as a potential therapeutic agent for patients with chronic heart failure...
  83. ncbi L-Ascorbate biosynthesis in peach: cloning of six L-galactose pathway-related genes and their expression during peach fruit development
    Tsuyoshi Imai
    National Institute of Fruit Tree Science, Fujimoto, Tsukuba, Ibaraki 305 8605, Japan
    Physiol Plant 136:139-49. 2009
    ..g. AsA III and IV). On the basis of these findings, we discuss the regulation of AsA biosynthesis in peach fruit...
  84. ncbi A novel class of amitogenic alginate microcapsules for long-term immunoisolated transplantation
    U Zimmermann
    Lehrstuhl fur Biotechnologie, Biozentrum, Universitat Wurzburg, Germany
    Ann N Y Acad Sci 944:199-215. 2001
    ..Transplantation studies in rats demonstrated that these capsules were functional over a period of more than two years...
  85. ncbi Preparation of dual crosslinked alginate-chitosan blend gel beads and in vitro controlled release in oral site-specific drug delivery system
    Yongmei Xu
    College of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, China
    Int J Pharm 336:329-37. 2007
    ..35, 1.96, 1.76% (in SGF 4 h), 82.86, 78.83, 52.91% (in SIF 3 h) and 97.84, 96.81, 87.26% (in SCF 3 h), which suggested that the dual crosslinked beads have potential small intestine or colon site-specific drug delivery property...
  86. ncbi Swelling studies and in vitro release of verapamil from calcium alginate and calcium alginate-chitosan beads
    George Pasparakis
    Department of Materials Science, University of Patras, 26504 Patras, Greece
    Int J Pharm 323:34-42. 2006
    ..The results were analyzed by using a semi-empirical equation and it was found that the drug release mechanisms were either "anomalous transport" or "case-II transport"...
  87. ncbi D-galacturonic acid catabolism in microorganisms and its biotechnological relevance
    Peter Richard
    VTT Technical Research Centre of Finland, PO Box 1000, 02044 VTT, Espoo, Finland
    Appl Microbiol Biotechnol 82:597-604. 2009
    ..In this paper, we review the microbial pathways for the catabolism of D-galacturonic acid that would be relevant for the microbial conversion to useful products...
  88. ncbi The Pseudomonas aeruginosa RpoS regulon and its relationship to quorum sensing
    Martin Schuster
    Department of Microbiology, W M Keck Microbial Communities and Cell Signaling Program, University of Iowa, Iowa City 52242, USA
    Mol Microbiol 51:973-85. 2004
    ..The transcription profiling results have allowed us to build a model that accommodates previous seemingly conflicting reports...
  89. pmc Calcium alginate microencapsulation of ovarian follicles impacts FSH delivery and follicle morphology
    Matthew Heise
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Reprod Biol Endocrinol 3:47. 2005
    ..Therefore, the objective of this study is to support three-dimensional follicle architecture during in vitro growth of ovarian follicles through encapsulation in calcium alginate, while maintaining responsiveness to FSH stimulation...
  90. ncbi Preparation of alginate-quaternary ammonium complex beads and evaluation of their antimicrobial activity
    Yoon Seok Kim
    Department of Microbiology, Chungnam National University, Daejeon 305 764, South Korea
    Int J Biol Macromol 41:36-41. 2007
    ..The present results indicate that these SA-TSA complex beads are a new type of insoluble cationic polymer that can kill or remove microorganisms in water by mere contact without releasing the reactive agent...
  91. ncbi Microencapsulation of a recombinant aminopeptidase (PepN) from Lactobacillus rhamnosus S93 in chitosan-coated alginate beads
    Sorayya Azarnia
    Department of Food Science and Agricultural Chemistry, McGill University, Ste Anne de Bellevue, QC, Canada
    J Microencapsul 25:46-58. 2008
    ..Increasing the CaCl2 concentration over 0.1 M neither affected the EE nor the ER. Increasing hardening time beyond 10 min led to a decrease in EE and the alginate:enzyme ratio (3 : 1) was optimal to prevent the ER...
  92. ncbi Insulin encapsulation in reinforced alginate microspheres prepared by internal gelation
    Catarina M Silva
    Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Rua do Norte, 3000 295 Coimbra, Portugal
    Eur J Pharm Sci 29:148-59. 2006
    ..Increasing the additive polymer concentration in the alginate matrix and/or chitosan-coating the blended alginate microspheres did not promote a sustained release of insulin from microspheres at pH 6.8...
  93. pmc A mutation in algN permits trans activation of alginate production by algT in Pseudomonas species
    J B Goldberg
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115 5899
    J Bacteriol 175:1303-8. 1993
    ..stutzeri, and P. fluorescens. Transconjugants of these species carrying algT DNA (with a deletion of algN) from pJF15 showed a mucoid phenotype and increased production of uronic acid-containing polymers that resembled alginate...
  94. pmc Quantitative assessment of islets of Langerhans encapsulated in alginate
    Amy S Johnson
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    Tissue Eng Part C Methods 17:435-49. 2011
    ....
  95. ncbi Anti-inflammatory effect with high intensity focused ultrasound-mediated pulsatile delivery of diclofenac
    Chih Yu Wang
    Department of Biomedical Engineering, I Shou University, Taiwan, ROC
    Biomaterials 33:1547-53. 2012
    ..60% higher). In addition, because of their heat conducting properties, gold nanoparticles encapsulated in the diclofenac-loaded microcapsules resulted in better drug release efficiency, but tended to depress the anti-inflammation effect...
  96. ncbi Survivability of probiotics encapsulated in alginate gel microbeads using a novel impinging aerosols method
    Asma Sohail
    School of Agriculture and Food Sciences, University of Queensland, St Lucia 4072, Australia
    Int J Food Microbiol 145:162-8. 2011
    ....
  97. ncbi Proteomic analysis of calcium alginate-immobilized Saccharomyces cerevisiae under high-gravity fermentation conditions
    Trong Khoa Pham
    Biological and Environmental Systems Group, Department of Chemical and Process Engineering, The University of Sheffield, Mappin Street, Sheffield S1 3JD, UK
    J Proteome Res 7:515-25. 2008
    ..The upregulation of ribosomal, heat-shock proteins and proteins involved in cell viability confirmed that protein biosynthesis was accelerated and revealed likely mechanisms for improving cellular viability...
  98. ncbi Alginate as a macroaffinity ligand and an additive for enhanced activity and thermostability of lipases
    S Sharma
    Chemistry Department, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi 110016, India
    Biotechnol Appl Biochem 33:161-5. 2001
    ..Furthermore, alginate was also found to protect the enzyme against thermoinactivation...
  99. ncbi Study of phenol biodegradation using Bacillus amyloliquefaciens strain WJDB-1 immobilized in alginate-chitosan-alginate (ACA) microcapsules by electrochemical method
    Daban Lu
    Department of Chemistry, Lanzhou University, Lanzhou, 730000, People s Republic of China
    Biodegradation 23:209-19. 2012
    ..This microorganism has the potential for the efficient treatment of organic pollutants in wastewater...
  100. pmc The pathway via D-galacturonate/L-galactonate is significant for ascorbate biosynthesis in Euglena gracilis: identification and functional characterization of aldonolactonase
    Takahiro Ishikawa
    Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane 690 8504, Japan
    J Biol Chem 283:31133-41. 2008
    ..The identification of aldonolactonase provides the first insight into the biosynthesis of AsA via uronic acids as the intermediate in photosynthetic algae including Euglena...
  101. ncbi FT-IR spectra of alginic acid block fractions in three species of brown seaweeds
    David Leal
    Departamento de Ciencias del Ambiente, Facultad de Quimica y Biologia, Universidad de Santiago de Chile, USACH, Av L B O Higgins 3363, Correo 33, Santiago, Chile
    Carbohydr Res 343:308-16. 2008
    ....

Research Grants33

  1. Application of alginate for endovascular embolization
    Timothy Becker; Fiscal Year: 2005
    ..The project team includes a core group of physicians, consultants, suppliers, and business alliances that has the technical, medical, and business expertise to make this project successful. ..
  2. Targeted Integration of Tissue Engineered Cartilage
    Jennifer Elisseeff; Fiscal Year: 2004
    ..Tissue integration will be monitored by morphological, biochemical, and mechanical analysis. ..
  3. 2005 Summer Bioengineering Conference
    Jennifer Wayne; Fiscal Year: 2005
    ..We expect to increase industrial participation in presentations and exhibits. The Summer Bioengineering Conference plays an important role in advancing the bioengineering field. ..
  4. Cardiovascular Effects of lyengar Yoga
    Raymond Townsend; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  5. Localized gene expression within P. aeruginosa biofilms
    Michael Franklin; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  6. Islet Transplantation - Protection by Immunobarriers
    Gordon Weir; Fiscal Year: 2007
    ..This work should serve as a guide for the encapsulation and transplantation of xenogeneic islets cells or insulin-producing cells that should eventually be produced from precursor/stem cells. ..
  7. Food Rheology and Feeding in Lean and Obese Humans
    Richard Mattes; Fiscal Year: 2007
    ..abstract_text> ..
  8. Role of OxyR in P. aeruginosa Biofilm Resistance to H202
    DANIEL HASSETT; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  9. Application of ALGEL for embolization of aneurysms
    Timothy Becker; Fiscal Year: 2004
    ..We feel that it is highly likely that ALGEL will turn out to be a clinically useful material. ..
  10. In Vivo Survival of an Engineered Cartilage Construct
    Jennifer Wayne; Fiscal Year: 2004
    ..Success of these in-vivo, dynamic models will provide a useful means for regenerating cartilage on articular surfaces subjected to severe mechanical loads. It can help pave the way for many clinical applications. ..
  11. Genetic basis of P. aeruginosa lung infections in mice
    Hongwei Yu; Fiscal Year: 2004
    ..The discovery of the mouse susceptibility gene may lead to the identification of the human homologue (lung-specific modifier gene) presumed to mediate susceptibility in the initial phase of infection. ..
  12. IRON, FUR AND ALGINATE PRODUCTION IN P AERUGINOSA
    DANIEL HASSETT; Fiscal Year: 2002
    ..Information derived from the studies proposed herein will advance the current knowledge about the role of these factors in the pathogenesis of P. aeruginosa infections in CF. ..
  13. CHONDROPROTECTIVE EFFECTS OF SUPEROXIDE DISMUTASE
    Constance Chu; Fiscal Year: 2002
    ..These studies will also serve to improve understanding of the relative roles of NO and peroxynitrite on the pathophysiology of arthritis. ..
  14. Proteogenome of Anaerobic P. aeruginosa in CF Mucus
    DANIEL HASSETT; Fiscal Year: 2003
    ..Our LONG TERM GOAL is to identify cellular targets that inhibit or significantly compromise the denitrification process that is occurring by P. aeruginosa in the CF airways. ..
  15. Exocyclic C-C Modifications of Aromatic Polyketides
    JON THORSON; Fiscal Year: 2008
    ..A particular focus of the final diversification strategies presented will be focused upon conjugation of these highly reactive antitumor antibiotics with known tumor-directing peptides. ..
  16. DIETARY SALT INTAKE AND THE METABOLIC EFFECTS OF INSULIN
    Raymond Townsend; Fiscal Year: 2003
    ..If increased salt intake improves insulin sensitivity this should prompt a re-evaluation of the benefits of recommending a lower sodium intake in normotensive people. ..
  17. B.pseudomallei bioterrorism and quorum sensing
    DANIEL HASSETT; Fiscal Year: 2003
    ..These studies will provide important information that will lead to countermeasures against a potential bioterrorist attack using the potentially lethal gram-negative bacterium, B. pseudomallei. ..
  18. GDF-5 Regulation in Intervertebral Disc Degeneration
    Xudong Li; Fiscal Year: 2008
    ..If successful in achieving meaningful repair, this project will help investigators make significant strides towards enabling disc repair in humans. [unreadable] [unreadable] [unreadable]..
  19. The influence of ischemic microenvironment and stem cell differentiation
    Randall Lee; Fiscal Year: 2008
    ..unreadable] Specific aim 2: To test the hypothesis that the microenvironment influences SC differentiation, angiogenesis and LV remodeling. [unreadable] [unreadable] [unreadable]..
  20. Improved efficacy of cochlear implants by directed regrowth of the auditory nerve
    JENNIFER CHIKAR; Fiscal Year: 2007
    ..The intent of this study is to improve the perception of sound from the implant and potentially provide the cochlear implant user with the ability to hear more complex sounds. [unreadable] [unreadable] [unreadable]..
  21. HEDONICS AND DIETARY INTAKE OF FAT
    Richard Mattes; Fiscal Year: 2008
    ..This will be explored through stable isotope tracer studies for Aim 3. The proposed work will hold important public health, clinical, commercial and basic biological implications. [unreadable] [unreadable]..
  22. Engineering and Integration of Osteochondral Tissue
    Jennifer Elisseeff; Fiscal Year: 2008
    ..Specific aim 3. Chemical attachment of hydrogels to cartilage for improved tissue-implant integration in the joint. ..
  23. Cellular Mechanisms Controlling Dog Oocyte Maturation
    Nucharin Songsasen; Fiscal Year: 2008
    ....
  24. AOSSM Post-Joint Injury Osteoarthritis Conference
    Constance Chu; Fiscal Year: 2008
    ..This symposium will bring doctors and scientists together to develop research plans to find new methods to prevent this from happening. [unreadable] [unreadable] [unreadable] [unreadable]..
  25. Development of a Multi-phased Scaffold for Soft Tissue to Bone Integration
    Helen Lu; Fiscal Year: 2006
    ..abstract_text> ..
  26. MECHANISTIC STUDIES OF PROKARYOTIC MANNOSYLTRANSFERASES
    JON THORSON; Fiscal Year: 2002
    ....
  27. Age-Related Differences in Cartilage OP-1
    Susan Chubinskaya; Fiscal Year: 2005
    ..This study will contribute to the understanding of the mechanisms of cartilage repair/anabolism. ..
  28. GENE EXPRESSION OF P AERUGINOSA DURING BIOFILM DEVELOPME
    Michael Franklin; Fiscal Year: 2004
    ..This information will provide important targets for anti-microbials , either through inhibition of sgis required for biofilm development, or through aberrant induction of genes normally repressed during biofilm growth. ..
  29. EFFECTS OF ALGINATE COMPOSITION ON ENCAPSULATED CELLS
    Ioannis Constantinidis; Fiscal Year: 2004
    ..Furthermore, the proposed NMR experiments will enhance our understanding of the capabilities of NMR to monitor a tissue-engineered construct in vitro and in vivo. ..
  30. PROTEASE SECRETION IN PSEUDOMONAS AERUGINOSA
    DENNIS OHMAN; Fiscal Year: 2003
    ..It also provides a model system for understanding a major pathway of protein export in gram-negative bacteria. ..
  31. Tissue Engineering in Congenital Craniofacial Defects
    Jennifer Elisseeff; Fiscal Year: 2009
    ..Normal and mutant mouse cell lines will be used in addition to a clonally-derived mouse mesenchymal stem cell line. Tissue development will be assessed by radiographic and histological analyses. ..
  32. Biomaterials as Decorporation Agents for Radionuclides
    TATIANA LEVITSKAIA; Fiscal Year: 2008
    ..abstract_text> ..