sialic acids

Summary

Summary: A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues.

Top Publications

  1. pmc Multifarious roles of sialic acids in immunity
    Ajit Varki
    Glycobiology Research and Training Center, Department of Medicine, University of California at San Diego, La Jolla, 92093 0687, USA
    Ann N Y Acad Sci 1253:16-36. 2012
  2. ncbi Sialic acids as regulators of molecular and cellular interactions
    Roland Schauer
    Biochemisches Institut, Christian Albrechts Universitat, Olshausenstr 40, D 24098 Kiel, Germany
    Curr Opin Struct Biol 19:507-14. 2009
  3. pmc Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids
    Zhongcheng Zou
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 6:e24559. 2011
  4. ncbi Hypersialylation of beta1 integrins, observed in colon adenocarcinoma, may contribute to cancer progression by up-regulating cell motility
    Eric C Seales
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Cancer Res 65:4645-52. 2005
  5. pmc Sialic acids in human health and disease
    Ajit Varki
    Glycobiology Research and Training Center, Departments of Medicine and Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093 0687, USA
    Trends Mol Med 14:351-60. 2008
  6. ncbi Polysialic acid-neural cell adhesion molecule in brain plasticity: from synapses to integration of new neurons
    Eduardo Gascon
    Department of Neuroscience, University of Geneva Medical School, 1, rue Michel Servet, CH 1211, Geneva, Switzerland
    Brain Res Rev 56:101-18. 2007
  7. ncbi alpha 2-6-Linked sialic acids on N-glycans modulate carcinoma differentiation in vivo
    Maria Hedlund
    Glycobiology Research and Training Center, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0687, USA
    Cancer Res 68:388-94. 2008
  8. pmc Alpha2,3 and alpha2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6
    Zhijian Wu
    Gene Therapy Center, CB 7352, 7119 Thurston Building, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7352, USA
    J Virol 80:9093-103. 2006
  9. ncbi Sialic acids in T cell development and function
    Shuguang Bi
    Department of Pathology and Laboratory Medicine, UCLA School of Medicine, 10833 LeConte Ave, Los Angeles, CA 90095, USA
    Biochim Biophys Acta 1790:1599-610. 2009
  10. pmc Human and avian influenza viruses target different cell types in cultures of human airway epithelium
    Mikhail N Matrosovich
    Institute of Virology, Philipps University, 35037 Marburg, Germany
    Proc Natl Acad Sci U S A 101:4620-4. 2004

Detail Information

Publications309 found, 100 shown here

  1. pmc Multifarious roles of sialic acids in immunity
    Ajit Varki
    Glycobiology Research and Training Center, Department of Medicine, University of California at San Diego, La Jolla, 92093 0687, USA
    Ann N Y Acad Sci 1253:16-36. 2012
    b>Sialic acids are a diverse family of monosaccharides widely expressed on all cell surfaces of vertebrates and so-called "higher" invertebrates, and on certain bacteria that interact with vertebrates...
  2. ncbi Sialic acids as regulators of molecular and cellular interactions
    Roland Schauer
    Biochemisches Institut, Christian Albrechts Universitat, Olshausenstr 40, D 24098 Kiel, Germany
    Curr Opin Struct Biol 19:507-14. 2009
    The wide occurrence of sialic acids (Sia) in various chemical forms linked as monomers or polymers in an outstanding position in a multitude of complex carbohydrates of animals and microorganisms renders them as most versatile function ..
  3. pmc Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids
    Zhongcheng Zou
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 6:e24559. 2011
    ....
  4. ncbi Hypersialylation of beta1 integrins, observed in colon adenocarcinoma, may contribute to cancer progression by up-regulating cell motility
    Eric C Seales
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Cancer Res 65:4645-52. 2005
    ..Collectively, these findings suggest that beta1 hypersialylation may augment colon tumor progression by altering cell preference for certain extracellular matrix milieus, as well as by stimulating cell migration...
  5. pmc Sialic acids in human health and disease
    Ajit Varki
    Glycobiology Research and Training Center, Departments of Medicine and Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093 0687, USA
    Trends Mol Med 14:351-60. 2008
    ..Most soluble secreted proteins are also similarly decorated with such glycans. Sialic acids are a diverse family of sugar units with a nine-carbon backbone that are typically found attached to the ..
  6. ncbi Polysialic acid-neural cell adhesion molecule in brain plasticity: from synapses to integration of new neurons
    Eduardo Gascon
    Department of Neuroscience, University of Geneva Medical School, 1, rue Michel Servet, CH 1211, Geneva, Switzerland
    Brain Res Rev 56:101-18. 2007
    ..In this review, we discuss the role and mode of actions of PSA-NCAM in structural plasticity as well as its potential link to cognitive processes...
  7. ncbi alpha 2-6-Linked sialic acids on N-glycans modulate carcinoma differentiation in vivo
    Maria Hedlund
    Glycobiology Research and Training Center, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0687, USA
    Cancer Res 68:388-94. 2008
    b>Sialic acids on vertebrate cell surfaces mediate many biological roles. Altered expression of certain sialic acid types or their linkages can have prognostic significance in human cancer...
  8. pmc Alpha2,3 and alpha2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6
    Zhijian Wu
    Gene Therapy Center, CB 7352, 7119 Thurston Building, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7352, USA
    J Virol 80:9093-103. 2006
    ..binds to NeuAcalpha2-3GalNAcbeta1-4GlcNAc, as well as two glycoproteins with alpha2,3 and alpha2,6 N-linked sialic acids. Taken together, competition, genetic, inhibitor, enzymatic reconstitution, and glycan array experiments ..
  9. ncbi Sialic acids in T cell development and function
    Shuguang Bi
    Department of Pathology and Laboratory Medicine, UCLA School of Medicine, 10833 LeConte Ave, Los Angeles, CA 90095, USA
    Biochim Biophys Acta 1790:1599-610. 2009
    ..One type of specific modification of cell surface glycans is decoration of glycan termini by sialic acids. On T cells, these terminal sialic acid residues are involved in almost every aspect of T cell fate and ..
  10. pmc Human and avian influenza viruses target different cell types in cultures of human airway epithelium
    Mikhail N Matrosovich
    Institute of Virology, Philipps University, 35037 Marburg, Germany
    Proc Natl Acad Sci U S A 101:4620-4. 2004
    ..This pattern correlated with the predominant localization of receptors for human viruses (2-6-linked sialic acids) on nonciliated cells and of receptors for avian viruses (2-3-linked sialic acids) on ciliated cells...
  11. ncbi Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule
    Birgit Weinhold
    Zelluläre Chemie, Zentrum Biochemie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Biol Chem 280:42971-7. 2005
    ....
  12. ncbi Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity
    Graziella Di Cristo
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11734, USA
    Nat Neurosci 10:1569-77. 2007
    ..The developmental and activity-dependent decline of PSA expression therefore regulates the timing of the maturation of GABAergic inhibition and the onset of ocular dominance plasticity...
  13. ncbi p75 neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells
    Kaylene M Young
    Queensland Brain Institute, The University of Queensland, Brisbane QLD 4072, Australia
    J Neurosci 27:5146-55. 2007
    ....
  14. ncbi Development of sensitive chemical and immunochemical methods for detecting sulfated sialic acids and their application to glycoconjugates from sea urchin sperm and eggs
    Nao Yamakawa
    Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan
    Biochimie 89:1396-408. 2007
    ..Thus, 8-O-sulfation is dependent on the species, gametic cell-type, site-localization of the eggs, and glycoconjugates...
  15. pmc Molecular mechanism underlying sialic acid as an essential nutrient for brain development and cognition
    Bing Wang
    School of Molecular Bioscience, University of Sydney, Australia
    Adv Nutr 3:465S-72S. 2012
    ..A diet rich in Sia also increases the level of Sia in the brains of postnatal piglets, the expression level of 2 learning-related genes, and enhances learning and memory...
  16. ncbi Amygdalar expression of proteins associated with neuroplasticity in major depression and suicide
    Marissa E Maheu
    Douglas Mental Health University Institute, Verdun, QC, Canada Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
    J Psychiatr Res 47:384-90. 2013
    ..The purpose of the present study was to investigate whether the expression of proteins involved in neuroplasticity is altered in the amygdala of individuals with depression...
  17. ncbi Chronic stress induces changes in the structure of interneurons and in the expression of molecules related to neuronal structural plasticity and inhibitory neurotransmission in the amygdala of adult mice
    Javier Gilabert-Juan
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Dpt, Universitat de Valencia, Spain
    Exp Neurol 232:33-40. 2011
    ..The addition of PSA to NCAM by St8SiaII may be involved in these changes...
  18. ncbi The human polyomavirus, JCV, uses serotonin receptors to infect cells
    Gwendolyn F Elphick
    Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    Science 306:1380-3. 2004
    ..A tagged 5HT2A receptor colocalized with labeled JCV in an endosomal compartment following internalization. Serotonin receptor antagonists may thus be useful in the treatment of progressive multifocal leukoencephalopathy...
  19. ncbi Alpha2,6-sialylation of cell-surface N-glycans inhibits glioma formation in vivo
    H Yamamoto
    Chicago Institute for Neurosurgery and Neuroresearch, Chicago, Illinois 60614, USA
    Cancer Res 61:6822-9. 2001
    Human gliomas express very high levels of cell-surface alpha2,3-linked terminal sialic acids on glycoproteins bearing N-linked oligosaccharides, most notably on alpha3beta1 integrin, which is the predominant integrin found in these tumors...
  20. ncbi Morpho-functional characterization of neuronal cells at different stages of maturation in granule cell layer of adult rat dentate gyrus
    Patrizia Ambrogini
    Istituto di Scienze Fisiologiche, Universita degli Studi di Urbino, Carlo Bo, Crocicchia, I 61029 Urbino, Italy
    Brain Res 1017:21-31. 2004
    ..Finally, cells showing electrophysiological, synaptic, and morphological features of mature granule, expressing the mature neuron marker NeuN, were identified...
  21. ncbi Expression of PSA-NCAM and synaptic proteins in the amygdala of psychiatric disorder patients
    Emilio Varea
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Dpt, Universitat de Valencia, Spain
    J Psychiatr Res 46:189-97. 2012
    ..These results indicate that inhibitory and excitatory amygdaloid circuits are affected in these disorders and that abnormal PSA-NCAM expression in depressive and bipolar patients may underlie these alterations...
  22. pmc Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin
    Emma Byres
    Protein Crystallography Unit and ARC Centre of Excellence for Structural and Functional Microbial Genomics, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Nature 456:648-52. 2008
    ..Ironically, foods rich in Neu5Gc are the most common source of STEC contamination. Thus a bacterial toxin's receptor is generated by metabolic incorporation of an exogenous factor derived from food...
  23. ncbi Effects of chronic stress on contextual fear conditioning and the hippocampal expression of the neural cell adhesion molecule, its polysialylation, and L1
    C Sandi
    Department of Psychobiology, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria s n, 28040, Madrid, Spain
    Neuroscience 102:329-39. 2001
    ..They also indicate that cell adhesion molecules might play a role in the structural remodelling that occurs in the hippocampus as a consequence of chronic stress exposure...
  24. ncbi Alterations in the expression of PSA-NCAM and synaptic proteins in the dorsolateral prefrontal cortex of psychiatric disorder patients
    Javier Gilabert-Juan
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Dpt, Universitat de Valencia, Spain
    Neurosci Lett 530:97-102. 2012
    ....
  25. ncbi Diversity in cell surface sialic acid presentations: implications for biology and disease
    Nissi M Varki
    Department of Pathology, Glycobiology Research and Training Center, University of California at San Diego, La Jolla, CA 92093 0687, USA
    Lab Invest 87:851-7. 2007
    b>Sialic acids (Sias) are typically found as terminal monosaccharides attached to cell surface glycoconjugates...
  26. ncbi Occurrence of sialic acids in healthy humans and different disorders
    P Sillanaukee
    Pharmacia and Upjohn AB Diagnostics, Uppsala, Sweden
    Eur J Clin Invest 29:413-25. 1999
    ..To become clinically useful, however, the existing SA determination assays need to be considerably refined to reduce interferences, to be specific for certain SA forms, and to be more easy to use...
  27. pmc Ectopic expression of polysialylated neural cell adhesion molecule in adult macaque Schwann cells promotes their migration and remyelination potential in the central nervous system
    C Bachelin
    Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, Universite Pierre et Marie Curie Paris 6, UMR S975, Paris, France
    Brain 133:406-20. 2010
    ..These results underline the potential therapeutic benefit to genetically modify Schwann cells to overcome their poor migration capacity and promote their repair potential in demyelinating disorders of the central nervous system...
  28. ncbi The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors
    Ian C Schoenhofen
    Institute for Biological Sciences, National Research Council, Ottawa, Ontario, K1A 0R6 Canada
    Glycobiology 19:715-25. 2009
    ....
  29. ncbi Non-granule PSA-NCAM immunoreactive neurons in the rat hippocampus
    Juan Nacher
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, York Avenue 1230, New York, NY 10021, USA
    Brain Res 930:1-11. 2002
    ..The presence of the polysialylated form of NCAM in these neurons could indicate that they are undergoing continuous remodeling during adulthood and may have an important role in hippocampal structural plasticity...
  30. ncbi Bactericidal monoclonal antibodies that define unique meningococcal B polysaccharide epitopes that do not cross-react with human polysialic acid
    D M Granoff
    Chiron Vaccines, Emeryville, CA 94608, USA
    J Immunol 160:5028-36. 1998
    ..These Abs may be useful for the identification of molecular mimetics capable of eliciting protective Abs specific to the bacteria, without the risk of evoking autoimmune disease...
  31. ncbi The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) is expressed in a subpopulation of mature cortical interneurons characterized by reduced structural features and connectivity
    Maria Angeles Gomez-Climent
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Department of Cell Biology, Universitat de Valencia, 46100 Burjassot, Spain
    Cereb Cortex 21:1028-41. 2011
    ..These data indicate that PSA-NCAM expression is important for the connectivity of interneurons in the adult cerebral cortex and that its regulation may play an important role in the structural plasticity of inhibitory networks...
  32. ncbi 9- O-acetylated sialic acids enhance entry of virulent Leishmania donovani promastigotes into macrophages
    A Ghoshal
    Infectious Disease and Immunology Division, Indian Institute of Chemical Biology, Jadavpur, Kolkata, India
    Parasitology 136:159-73. 2009
    Distribution of 9-O-acetylated sialic acids (9-O-AcSA) on Leishmania donovani has been previously reported...
  33. pmc Advances in the biology and chemistry of sialic acids
    Xi Chen
    Department of Chemistry, University of California, Davis, California 95616, USA
    ACS Chem Biol 5:163-76. 2010
    b>Sialic acids are a subset of nonulosonic acids, which are nine-carbon alpha-keto aldonic acids...
  34. pmc Glycan analysis and influenza A virus infection of primary swine respiratory epithelial cells: the importance of NeuAc{alpha}2-6 glycans
    Allen C Bateman
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Biol Chem 285:34016-26. 2010
    ....
  35. ncbi Role of sialic acid-containing molecules in paramyxovirus entry into the host cell: a minireview
    Enrique Villar
    Departamento de Bioquimica y Biologia Molecular, Edificio Departamental, Universidad de Salamanca, Plaza Doctores de la Reina s n, Lab 108, Salamanca 37007, Spain
    Glycoconj J 23:5-17. 2006
    ..In spite of all these data, the exact nature of paramyxovirus receptors, apart from their sialylated nature, and the mechanism(s) of viral attachment to the cell surface are poorly understood...
  36. ncbi UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation
    O T Keppler
    Applied Tumor Virology Program, Tumor Immunology Program, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Science 284:1372-6. 1999
    ..UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell lines and a critical regulator of the function of specific cell surface adhesion molecules...
  37. ncbi Pseudaminic acid, the major modification on Campylobacter flagellin, is synthesized via the Cj1293 gene
    Scarlett Goon
    Enteric Diseases Department, Naval Medical Research Center, Silver Spring, MD 20910, USA
    Mol Microbiol 50:659-71. 2003
    ..Collectively, the data indicate that Cj1293 is essential for Pse5Ac7Ac biosynthesis from UDP-GlcNAc, and that glycosylation is required for flagella biogenesis in campylobacters...
  38. pmc Polysialic acid neural cell adhesion molecule (PSA-NCAM) is an adverse prognosis factor in glioblastoma, and regulates olig2 expression in glioma cell lines
    Marie Claude Amoureux
    Université de la Méditerranée CNRS UMR6216, Institut de Biologie du Developpement de Marseille Luminy, Marseille, France
    BMC Cancer 10:91. 2010
    ..Here, we studied its expression in GBM and evaluated its prognosis value for overall survival (OS) and disease free survival (DFS)...
  39. pmc Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation
    Jafar Mahdavi
    Department of Odontology Oral Microbiology, Umea University, SE 901 87 Umea, Sweden
    Science 297:573-8. 2002
    ..The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection...
  40. ncbi PSA-NCAM expression in the human prefrontal cortex
    Emilio Varea
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Department, Universitat de Valencia, Dr Moliner 50, Burjassot 46100, Spain
    J Chem Neuroanat 33:202-9. 2007
    ..Since this molecule has been linked to the neuronal remodeling found in experimental models of depression, it may also participate in the structural plasticity described in the PFC of depressed patients...
  41. ncbi Distribution of PSA-NCAM expression in the amygdala of the adult rat
    J Nacher
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Neuroscience 113:479-84. 2002
    ..PSA-NCAM expression in the lateral amygdala could indicate its participation in the plastic events that lead to the generation of emotional memories such as those related to fear conditioning...
  42. pmc Detection of influenza viruses resistant to neuraminidase inhibitors in global surveillance during the first 3 years of their use
    Arnold S Monto
    University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Antimicrob Agents Chemother 50:2395-402. 2006
    ..The frequency of variants with decreased sensitivity to the NAIs did not increase significantly during this period, but continued surveillance is required, especially in regions with higher NAI use...
  43. ncbi Direct evidence that neural cell adhesion molecule (NCAM) polysialylation increases intermembrane repulsion and abrogates adhesion
    Colin P Johnson
    Department of Chemistry, University of Illinois at Urbana Champaign, Illinois 61801, USA
    J Biol Chem 280:137-45. 2005
    ..These findings agree qualitatively with independent reports based on cell adhesion studies and reveal the likely molecular mechanism by which NCAM polysialylation regulates cell adhesion and intermembrane space...
  44. ncbi Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat
    M Sairanen
    Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, P O Box 56, 00014 University of Helsinki, Helsinki, Finland
    Neuroscience 144:368-74. 2007
    ..Taken together, the results of the present study suggest that antidepressant treatment increases synaptic plasticity and connectivity in brain regions associated with mood disorders...
  45. pmc Reduced susceptibility to colitis-associated colon carcinogenesis in mice lacking plasma membrane-associated sialidase
    Kazunori Yamaguchi
    Division of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, Natori, Japan
    PLoS ONE 7:e41132. 2012
    b>Sialic acids are acidic monosaccharides that bind to the sugar chains of glycoconjugates and change their conformation, intermolecular interactions, and/or half-life...
  46. ncbi Protein sialylation by sialyltransferase involves radiation resistance
    Minyoung Lee
    Division of Radiation Effect, Korea Institute of Radiological and Medical Sciences, Seoul, Korea
    Mol Cancer Res 6:1316-25. 2008
    ..However, removal of sialic acids by neuraminidase 2 or knockdown of expression by short interfering RNA targeting ST6Gal I restored radiation-..
  47. ncbi Neural cell adhesion molecule-associated polysialic acid inhibits NR2B-containing N-methyl-D-aspartate receptors and prevents glutamate-induced cell death
    Martin S L Hammond
    Zentrum für Molekulare Neurobiologie Hamburg and Institut für Neurophysiologie und Pathophysiologie, Universitatsklinikum Hamburg Eppendorf, 20246 Hamburg, Germany
    J Biol Chem 281:34859-69. 2006
    ..These observations indicate that the cell adhesion molecule-associated glycan polysialic acid is able to prevent excitotoxicity via inhibition of NR2B subunit-containing NMDA receptors...
  48. ncbi Quantum dots with phenylboronic acid tags for specific labeling of sialic acids on living cells
    Aiping Liu
    School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore
    Anal Chem 83:1124-30. 2011
    b>Sialic acids with a nine-carbon backbone are commonly found at the terminal position of the glycans structures on cell membranes...
  49. ncbi Biosynthesis and production of polysialic acids in bacteria
    Miguel Angel Ferrero
    Departamento de Biologia Molecular, Universidad de Leon, Campus de Vegazana, 24071, Leon, Spain
    Appl Microbiol Biotechnol 86:1621-35. 2010
    ..In vivo PA production is affected by different physical and chemical factors. The temperature of cellular growth strictly regulates PA genesis through a molecular complex and multifactorial mechanism that operate to transcription level...
  50. pmc Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophrenia
    Ryo Isomura
    Bioscience and Biotechnology Center, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 286:21535-45. 2011
    ....
  51. pmc Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase
    Miriam Cohen
    Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla 92093, California, USA
    Virol J 10:321. 2013
    Influenza A virus (IAV) neuraminidase (NA) cleaves sialic acids (Sias) from glycans. Inhibiting NA with oseltamivir suppresses both viral infection, and viral release from cultured human airway epithelial cells...
  52. ncbi Sialylated ligands on pathogenic Trypanosoma cruzi interact with Siglec-E (sialic acid-binding Ig-like lectin-E)
    Hanna Erdmann
    Department of Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Cell Microbiol 11:1600-11. 2009
    ..Indeed, Siglec-E interacted with the pathogenic Tulahuen strain, but showed a diminished binding to the Tehuantepec strain. Ligation of Siglec-E on DC using antibodies confirmed this inhibitory effect on DC function...
  53. ncbi O-acetylation and de-O-acetylation of sialic acids in human colorectal carcinoma
    Yanqin Shen
    Biochemisches Institut, Christian Albrechts Universitat zu Kiel, Germany
    Eur J Biochem 271:281-90. 2004
    A decrease in the level of O-acetylated sialic acids observed in colorectal carcinoma may lead to an increase in the expression of sialyl Lewis(X), a tumor-associated antigen, which is related to progression of colorectal cancer to ..
  54. pmc Sialylation of beta1 integrins blocks cell adhesion to galectin-3 and protects cells against galectin-3-induced apoptosis
    Ya Zhuo
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 283:22177-85. 2008
    ..Removal of alpha2-6 sialic acids from ST6Gal-I expressors by neuraminidase treatment restores gal-3 binding...
  55. ncbi Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus
    James Stevens
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 312:404-10. 2006
    ....
  56. ncbi Chronic restraint stress down-regulates amygdaloid expression of polysialylated neural cell adhesion molecule
    M I Cordero
    Department of Biological Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, UK
    Neuroscience 133:903-10. 2005
    ..Furthermore, these finding provide the first clear evidence that life experiences can regulate the expression of polysialylated neural cell adhesion molecule in the amygdaloid complex...
  57. ncbi Brain development needs sugar: the role of polysialic acid in controlling NCAM functions
    Martina Muhlenhoff
    Institute of Cellular Chemistry, OE 4330, Hannover Medical School, D 30625 Hannover, Germany
    Biol Chem 390:567-74. 2009
    ....
  58. ncbi Inhibitors of sialyltransferases: potential roles in tumor growth and metastasis
    N B Drinnan
    Alchemia Pty Ltd, 3 Hi Tech Court, Brisbane Technology Park, Eight Mile Plains, Qld 4113, Australia
    Mini Rev Med Chem 3:501-17. 2003
    ..Over the years attempts have been made to synthesize inhibitors of sialyltransferases in a effort to assist in the validation or dissolution of these enzymes as potential therapeutic targets...
  59. ncbi The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis
    Emma C Nilsson
    Department of Clinical Microbiology, Division of Virology, Umea University, Umea, Sweden
    Nat Med 17:105-9. 2011
    ..binds a branched hexasaccharide that is present in the GD1a ganglioside and that features two terminal sialic acids. Soluble GD1a glycan and GD1a-binding antibodies efficiently prevented Ad37 virions from binding and infecting ..
  60. pmc A sialylated glycan microarray reveals novel interactions of modified sialic acids with proteins and viruses
    Xuezheng Song
    Department of Biochemistry and The Glycomics Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 286:31610-22. 2011
    ..we describe studies on sialic acid recognition using a novel sialylated glycan microarray containing modified sialic acids presented on different glycan backbones...
  61. ncbi O-acetylation of sialic acids in N-glycans of Atlantic salmon (Salmo salar) serum is altered by handling stress
    Xin Liu
    Institute for Biological Sciences, National Research Council Canada, Ontario, Canada
    Proteomics 8:2849-57. 2008
    O-acetylation is one of the major modifications of sialic acids that significantly alters biological properties of the parent molecule...
  62. ncbi Estrogens regulate posttranslational modification of neural cell adhesion molecule during the estrogen-induced gonadotropin surge
    Orkun Tan
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York 10016, USA
    Endocrinology 150:2783-90. 2009
    ..05), indicating that these enzymes are regulated by estrogens. These results support estrogen-regulated formation and extrusion of hydrophilic PSA-NCAM into perineural spaces in the PVA as part of the mechanism of EISP...
  63. ncbi Polysialic acid in the plasticity of the developing and adult vertebrate nervous system
    Urs Rutishauser
    Department of Cell Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Neurosci 9:26-35. 2008
    ..The ability of PSA to increase the plasticity of neural cells is being exploited to improve the repair of adult CNS tissue...
  64. ncbi Impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid synthesis during postnatal mouse brain development
    Imke Oltmann-Norden
    Institute of Cellular Chemistry, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Biol Chem 283:1463-71. 2008
    ....
  65. pmc Sialic acid functions in enterovirus 70 binding and infection
    David A Alexander
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Virol 76:11265-72. 2002
    ..Treatment of cells with metabolic inhibitors of glycosylation excluded a role for the N-linked oligosaccharides of glycoproteins but suggested that O-linked glycosylation is important for EV70 binding...
  66. pmc Viruses and sialic acids: rules of engagement
    Ursula Neu
    Interfaculty Institute of Biochemistry, University of Tubingen, Hoppe Seyler Str 4, D 72076 Tubingen, Germany
    Curr Opin Struct Biol 21:610-8. 2011
    ..An improved understanding of the principles that govern the recognition of sialic acid and sialylated oligosaccharides would also advance efforts to develop efficient antiviral agents...
  67. ncbi N-glycolylneuraminic acid deficiency in humans
    A Varki
    Glycobiology Research and Training Center and Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0687, USA
    Biochimie 83:615-22. 2001
    ..This review provides an update on this matter, and considers a variety of other old and new questions that arise from it...
  68. pmc Developmental regulation of neural cell adhesion molecule in human prefrontal cortex
    E T Cox
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuroscience 162:96-105. 2009
    ....
  69. ncbi Polysialylation of NCAM is upregulated by hyperthermia and participates in heat shock preconditioning-induced neuroprotection
    V Duveau
    Universite Bordeaux 2, CNRS UMR 5227 Mouvement, Adaptation, Cognition, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France
    Neurobiol Dis 26:385-95. 2007
    ..The upregulation of PSA-NCAM by hyperthermia may have a significant impact on hippocampal plasticity, permitting induction of the complex molecular cascade responsible for neuroprotection...
  70. ncbi Cutting edge: an inducible sialidase regulates the hyaluronic acid binding ability of CD44-bearing human monocytes
    S Katoh
    Third Department of Internal Medicine, Miyazaki Medical College, Japan
    J Immunol 162:5058-61. 1999
    ..Monocytes may be capable of enzymaticly remodeling cell surface CD44, altering their ability to interact with the extracellular matrix...
  71. ncbi Orally active neurotrophin-enhancing agent protects against dysfunctions of the peripheral nerves in hyperglycemic animals
    Bunpei Kakinoki
    Research Laboratory I, Pharmaceutical Research Unit, Research and Development Division, Mitsubishi Pharma Corporation, 1000, Kamoshida cho, Aoba ku, Yokohama 227 0033, Japan
    Diabetes 55:616-21. 2006
    ..Thus, the orally active neurotrophin enhancer provides a new option for the clinical treatment of diabetic peripheral neuropathy...
  72. ncbi The role of polysialic acid in migration of olfactory bulb interneuron precursors in the subventricular zone
    H Hu
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Neuron 16:735-43. 1996
    ....
  73. ncbi Sialyltransferase ST8Sia-II assembles a subset of polysialic acid that directs hippocampal axonal targeting and promotes fear behavior
    Kiyohiko Angata
    Glycobiology Program, Cancer Research Center, The Burnham Institute, La Jolla, CA 92037, USA
    J Biol Chem 279:32603-13. 2004
    ..This genetic partitioning of PSA formation engenders discrete neurological processes and reveals that this post-translational modification forms the predominant basis for the multiple functions attributed to the NCAM glycoprotein...
  74. ncbi Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis
    Mai Zhang
    Glycobiology Research and Training Center, Departments of Medicine and Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0687, USA
    Glycobiology 14:939-49. 2004
    ..CD22 recognizes alpha2-6-linked sialic acids (Sias) via an amino-terminal Ig-like domain...
  75. ncbi Polysialic acid regulates the clustering, migration, and neuronal differentiation of progenitor cells in the adult hippocampus
    Alison Burgess
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada M5G 1L9
    Dev Neurobiol 68:1580-90. 2008
    ....
  76. ncbi Histochemical analysis of sialic acids in the epididymis of the rat
    T Ueda
    2nd Department of Anatomy, Nagoya City University Medical School, Nagoya, Japan
    Histochem Cell Biol 109:399-407. 1998
    A variety of sialic acids contained in the rat epididymis were histochemically examined by means of lectin and pre-lectin methods by light microscopy...
  77. pmc Generation and characterization of variants of NWS/G70C influenza virus after in vitro passage in 4-amino-Neu5Ac2en and 4-guanidino-Neu5Ac2en
    J L McKimm-Breschkin
    Biomolecular Research Institute, Parkville, Australia
    Antimicrob Agents Chemother 40:40-6. 1996
    ..Compensating mutations resulting in a weakly binding hemagglutinin thus seem to be circumventing the inhibition of the neuraminidase by allowing the virus to be released from cells with less dependence on the neuraminidase...
  78. ncbi Infection with human H1N1 influenza virus affects the expression of sialic acids of metaplastic mucous cells in the ferret airways
    S Kirkeby
    Dental School, Faculty of Health Sciences, University of Copenhagen, Denmark
    Virus Res 144:225-32. 2009
    Glycans terminating in sialic acids serve as receptors for influenza viruses...
  79. ncbi Different polysialic acid-neural cell adhesion molecule expression patterns in distinct types of mossy fiber boutons in the adult hippocampus
    T Seki
    Department of Anatomy, Juntendo University, School of Medicine, Tokyo, Japan
    J Comp Neurol 410:115-25. 1999
    ....
  80. ncbi Divergent impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid expression in immature neurons and interneurons of the adult cerebral cortex
    J Nacher
    Cell Biology Department, Universitat de Valencia, Burjassot, Spain
    Neuroscience 167:825-37. 2010
    ..However, many of the immature granule neurons showed aberrant locations and morphology, suggesting a role of ST8SiaII in their terminal differentiation...
  81. ncbi Neural cell adhesion molecule-associated polysialic acid regulates synaptic plasticity and learning by restraining the signaling through GluN2B-containing NMDA receptors
    Gaga Kochlamazashvili
    Zentrum fur Molekulare Neurobiologie Hamburg, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    J Neurosci 30:4171-83. 2010
    ....
  82. pmc Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition
    Biswajit Khatua
    Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, Kolkata, India
    FEBS Lett 584:555-61. 2010
    ..of Pseudomonas aeruginosa (PA) in immunocompromised hosts prompted us to explore the potential role of sialic acids (Sia) in this phenomenon...
  83. ncbi Sialic acids in different Leishmania sp., its correlation with nitric oxide resistance and host responses
    Angana Ghoshal
    Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, A Unit of Council of Scientific and Industrial Research C S I R, Govt of India, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700 032, India
    Glycobiology 20:553-66. 2010
    The presence of different derivatives of sialic acids (SA) on Leishmania donovani instigated us to investigate their status on different strains of Leishmania sp. causing different forms of the disease...
  84. ncbi Learning under stress: a role for the neural cell adhesion molecule NCAM
    Reto Bisaz
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    Neurobiol Learn Mem 91:333-42. 2009
    ....
  85. ncbi O-acetylation of sialic acids is required for the survival of lymphoblasts in childhood acute lymphoblastic leukemia (ALL)
    Shyamasree Ghosh
    Immunobiology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Kolkata 700 032, India
    Glycoconj J 24:17-24. 2007
    ..Taken together, it may be hypothesized that Neu5,9Ac(2)-GPs and their antibodies play a prominent role in promoting the survival of lymphoblasts in ALL...
  86. ncbi Identification of sialic acids on Leishmania donovani amastigotes
    Anil K Chava
    Immunobiology Division, Indian Institute of Chemical Biology, 4, S C Mullick Road, Jadavpur, 700 032 Kolkata, India
    Biol Chem 385:59-66. 2004
    ..agglutinin (MAA), and various Siglecs, showed the presence of both (alpha2 --> 6)- and (alpha2 --> 3)-linked sialic acids; their binding was reduced after sialidase pretreatment...
  87. ncbi Hippocampal up-regulation of NCAM expression and polysialylation plays a key role on spatial memory
    Cesar Venero
    Department of Psychobiology, Universidad Nacional de Educacion a Distancia, Juan del Rosal 10, Madrid, Spain
    Eur J Neurosci 23:1585-95. 2006
    ..Therefore, our findings highlight NCAM as a learning-modulated molecule critically involved in the hippocampal remodeling processes underlying spatial memory formation...
  88. ncbi Improving the therapeutic efficacy of peptides and proteins: a role for polysialic acids
    Gregory Gregoriadis
    School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Int J Pharm 300:125-30. 2005
    ..It is anticipated that polysialylation will lead to a new generation of peptide and protein constructs with significantly improved pharmacological profiles...
  89. ncbi Upregulation of polysialylated neural cell adhesion molecule in the dorsal hippocampus after contextual fear conditioning is involved in long-term memory formation
    Miguel A Lopez-Fernandez
    Brain Mind Institute, Swiss Federal Institute of Technology, CH 1015 Lausanne, Switzerland
    J Neurosci 27:4552-61. 2007
    ....
  90. ncbi Sulfonation and sialylation of gonadotropins in women during the menstrual cycle, after menopause, and with polycystic ovarian syndrome and in men
    Leif Wide
    Department of Medical Sciences, University Hospital, SE 751 85 Uppsala, Sweden
    J Clin Endocrinol Metab 92:4410-7. 2007
    ..These charge alterations may reflect differences in the number of two negatively charged residues on the gonadotropins: sialic acid and sulfonated N-acetylgalactosamine, residues that modulate the half-life of the gonadotropins in blood...
  91. ncbi PSA-NCAM modulates BDNF-dependent survival and differentiation of cortical neurons
    L Vutskits
    Department of Morphology, University of Geneva Medical School, 1 rue Michel Servet, CH-1211 Geneva 4, Switzerland
    Eur J Neurosci 13:1391-402. 2001
    ..These data suggest that PSA-NCAM, previously shown to modulate cell migration and plasticity, is needed for an adequate sensitivity of neurons to BDNF...
  92. ncbi Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus
    Kara Pham
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Eur J Neurosci 17:879-86. 2003
    ..These studies may help us understand the basis for hippocampal shrinkage and raise questions about the ultimate reversibility of the effects of chronic stress...
  93. ncbi Characterization of the N-acetyl-5-neuraminic acid-binding site of the extracytoplasmic solute receptor (SiaP) of nontypeable Haemophilus influenzae strain 2019
    Jason W Johnston
    Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 283:855-65. 2008
    ..The decreased ability of H. influenzae to import sialic acid had negative effects on resistance to complement-mediated killing and viability of biofilms in vitro, confirming the importance of sialic acid transport to the bacterium...
  94. ncbi Polysialylated neural cell adhesion molecule is involved in induction of long-term potentiation and memory acquisition and consolidation in a fear-conditioning paradigm
    Oleg Senkov
    Center for Molecular Neurobiology, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
    J Neurosci 26:10888-109898. 2006
    ..In conclusion, our data support the view that polysialylated NCAM is involved in both formation and late consolidation of contextual memory...
  95. ncbi Imbalance of neural cell adhesion molecule and polysialyltransferase alleles causes defective brain connectivity
    Herbert Hildebrandt
    Institute of Cellular Chemistry, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Brain 132:2831-8. 2009
    ....
  96. pmc Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure
    Amanda L Lewis
    Glycobiology Research and Training Center, Departments of Pediatrics, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:13552-7. 2009
    b>Sialic acids (Sias) are nonulosonic acid (NulO) sugars prominently displayed on vertebrate cells and occasionally mimicked by bacterial pathogens using homologous biosynthetic pathways...
  97. pmc Capsule switching of Neisseria meningitidis
    J S Swartley
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
    Proc Natl Acad Sci U S A 94:271-6. 1997
    ..As vaccine development progresses and broader immunization with capsular polysaccharide conjugate vaccines becomes a reality, the ability to switch capsular types may have important implications for the impact of these vaccines...
  98. ncbi Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon
    E Varea
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Department, Universitat de Valencia, Spain
    Eur Neuropsychopharmacol 17:546-57. 2007
    ..The expression of these molecules is also affected in the entorhinal, the visual and the somatosensory cortices...
  99. ncbi A small-molecule modulator of poly-alpha 2,8-sialic acid expression on cultured neurons and tumor cells
    L K Mahal
    Department of Chemistry, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA
    Science 294:380-1. 2001
    ..Modulation of PSA expression by chemical means has a role complementary to genetic and biochemical approaches in the study of complex PSA-mediated events...
  100. ncbi Chronic fluoxetine treatment increases the expression of PSA-NCAM in the medial prefrontal cortex
    Emilio Varea
    Cell Biology Department, Neurobiology Unit, Program in Basic and Applied Neurosciences, Universitat de Valencia, Burjassot, Spain
    Neuropsychopharmacology 32:803-12. 2007
    ..This modulation may mediate the structural plasticity of this cortical region and opens new perspectives on the study of the molecular bases of depression...
  101. ncbi Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning
    H Cremer
    Institute for Genetics, University of Cologne, Germany
    Nature 367:455-9. 1994
    ..The animals showed deficits in spatial learning when tested in the Morris water maze, whereas activity and motor abilities appeared normal...

Research Grants63

  1. Regulation of the Poly Sialic Virulence Factor
    ERIC ROSS VIMR; Fiscal Year: 2013
    ..involved in the reciprocal addition (NeuD) or subtraction (NeuA*) of O- acetyl esters to or from monomeric sialic acids prior to their incorporation into polysialic acid...
  2. The Endothelial Glycocalyx: Its Structure and Function and as a Mechanotransducer
    John M Tarbell; Fiscal Year: 2013
    ..coated with a glycocalyx of membrane-bound macromolecules comprised of sulfated proteoglycans, hyaluronic acid, sialic acids, glycocproteins and plasma proteins that adhere to this surface matrix...
  3. Oligosaccharies of Normal and Malignant Cells
    Ajit P Varki; Fiscal Year: 2013
    ..b>Sialic acids (Sias) are attached to underlying glycans in various linkages, and can be modified in several ways...
  4. Multi-ligand merozoite invasion blocking malaria vaccine
    B Kim Lee Sim; Fiscal Year: 2013
    ..A well-studied Pf ligand is EBA-175 that binds its receptor sialic acids on glycophorin A. Antibodies to EBA-175 can block parasite invasion...
  5. BIOLOGY OF SIALIC ACIDS AND THEIR SUBSTITUTIONS
    Ajit P Varki; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Sialic Acids (Sias) are molecules attached to the outer ends of sugar chains (glycans) on cell surface and secreted molecules of vertebrates...
  6. Excessive Lysosomal Exocytosis Triggers Pathogenic Mechanisms in Sialidosis Mice
    ALESSANDRA D'AZZO; Fiscal Year: 2013
    ..NEU1 initiates the hydrolysis of sialo-glycoconjugates by removing their terminal sialic acids. The loss of NEU1 activity results in oversialylation of its substrates, which in turn, can change their ..
  7. GENETIC MODULATION OF BLOOD AND VASCULAR GLYCOSYLATION
    NISSI MARY VARKI; Fiscal Year: 2012
    ..to focus on two major types of anionic glycans at the outermost aspects of the cell surface glycocalyx - Sialic Acids (Sias) and the Glycosaminoglycan (GAG) chains Hyaluronan (HA), Heparan sulfate (HS) and Chondrotin suflate/..
  8. Regulation of the Poly Sialic Virulence Factor
    Eric Vimr; Fiscal Year: 2009
    ..involved in the reciprocal addition (NeuD) or subtraction (NeuA*) of O- acetyl esters to or from monomeric sialic acids prior to their incorporation into polysialic acid...
  9. Super-resolution studies of the entry mechanisms of influenza viruses
    Xiaowei Zhuang; Fiscal Year: 2013
    ..While influenza virus binds to cells through cell-surface sialic acids, various experiments suggest that influenza virus entry may require specific protein receptors in addition to ..
  10. Novel Approaches for Structural Determination of Cancer Stem Cell Glycans
    Kristina Hakansson; Fiscal Year: 2012
    ..A second challenge is the determination of saccharide branching and specific linkage. Also, sialic acids and sulfate groups are extremely labile, further compromising ionization and rendering sulfate localization ..
  11. Microbial Recognition of Sialic Acid Diversity in the Salivary Proteome
    STEFAN HANS KLAUS RUHL; Fiscal Year: 2013
    ..there exists additional not yet well understood complexity in the structural presentation or substitution of sialic acids on salivary glycoproteins that are likely to influence adhesin-mediated bacterial binding by both, commensal ..
  12. Glycan Diversity and Anti-Glycan Antibodies as Barriers to Gene Flow
    Pascal Gagneux; Fiscal Year: 2013
    ..Mammalian glycans commonly terminate in sugars called sialic acids (Sias). The two most common Sias are N-Acetylneuraminic acid (Neu5Ac) and N- Glycolylneuraminic acid (Neu5Gc)...
  13. Virion Sialic Acid and HSV Ocular Infection
    Curtis R Brandt; Fiscal Year: 2011
    ..we described a peptide, TAT-C, that inhibits HSV-1 infection and preliminary data suggests TAT-C binds to sialic acids on viral envelope proteins...
  14. Metabolic Engineering with Bioorthogonal Chemical Reporters
    Carolyn R Bertozzi; Fiscal Year: 2013
    ..We performed non-invasive imaging of sialic acids in healthy mice by metabolic labeling with N-azidoacetylmannosamine (ManNAz) followed by sequential injection ..
  15. Glycan Modulation of Inflammatory Responses
    Ajit P Varki; Fiscal Year: 2013
    ..A particular focus is on roles of two major types of anionic glycans: sialic acids (Sias) and the glycosaminoglycans (GAGs), hyaluronan (HA), heparan sulfate (HS) and chondroitin sulfate/..
  16. The Promotion of Inflammation by Bacterial Sialidases After Influenza Infection
    NICHOLAS KORTEN BROWN; Fiscal Year: 2013
    ..Since the interaction depends on sialic acids on CD24 and is susceptible to bacterial sialidase cleavage, I hypothesize that sialidase encoded by bacteria ..
  17. Proof-of-Principle Studies of DAS181 for Parainfluenza Virus Infection
    Fang Fang; Fiscal Year: 2010
    ..of a sialidase catalytic domain fused with an epithelium-anchoring sequence which functions by eliminating sialic acids on the airway epithelium...
  18. NMR of cell surface oligosaccharides
    James H Prestegard; Fiscal Year: 2012
    ..forms, remodeling of glycan residues on siglecs to improve glycan homogeneity and add isotopically labeled sialic acids, development of new NMR resonance assignment strategies for these labeled glycans, collection and ..
  19. Anti-GM1b IgM for Detection of Localized Prostate Cancer
    Mepur Ravindranath; Fiscal Year: 2005
    ..ceramide-mediated apoptosis by glycosylating ceramides and storing them as gangliosides (lactosylceramides with sialic acids) suggests that gangliosides (Ggs) may be valuable targets for diagnostic and therapeutic explorations...
  20. Falciparum malaria invasion ligand DNA/protein vaccine
    David Narum; Fiscal Year: 2002
    ..Pf invades erythrocytes (RBCs) by attaching to surface receptors, one of which includes sialic acids. We identified a novel erythrocyte binding protein-2 (EBP2) and the putative domain of the RBC receptor-binding ..
  21. ENZYMIC AND NON-ENZYMIC GLYCOSYL TRANSFER
    Michael Sinnott; Fiscal Year: 1993
    ..SNi) mechanism, and reactions of derivatives with a carboxylic acid attached to the reaction center (not only sialic acids but also glycosides of 3-deoxy-D-manno-2-octulosonic acid (KDO)...
  22. REDOX GLYCOSIDATION
    ANTHONY BARRETT; Fiscal Year: 1992
    ..Secondly the method is of little use in the elaboration of many biologically active materials, for example, the sialic acids. There is a need for a simple and general procedure to readily assemble oligosaccharides from aldose and ketose ..
  23. Plant-produced Asialo-erythropoietin and its Antiapoptotic Functions
    Jiahua Xie; Fiscal Year: 2012
    ..we are taking the distinct advantage of plant expression systems, which is the lack of the capacity to add sialic acids, to genetically modify plants for asialo-rhuEPO - a special glycoprotein without sialic acids...
  24. IMMUNE RESPONSES TO CLYCOSYLATION-MODIFIED SIV VACCINES
    David Montefiori; Fiscal Year: 1993
    ..mannosidase I inhibitor) and swainsonine (mannosidase II inhibitor) or by enzymatic removal of sialic acids using neuraminidase...
  25. SIALIC ACID MODULATION REGULATES NEUTROPHIL DIAPEDESIS
    Alan Cross; Fiscal Year: 2002
    DESCRIPTION (Adapted from the applicant's abstract): Sialic acids are amino sugars that are present on mammalian cells as glycoconjugates and impart to these cells a negative surface charge...
  26. FALCIPARUM MALARIA INVASION LIGAND VACCINE NE
    B Sim; Fiscal Year: 1999
    ..The parasite invades erythrocytes by attaching to surface receptors, one of which is sialic acids on glycophorin A. The 175 kD P...
  27. PATHOGENESIS OF PNEUMOCYSTIS CARINII PNEUMONIA
    MIERCIO PEREIRA; Fiscal Year: 1999
    ..The role of sialic acids and sialic-acid -binding proteins (i...
  28. RECOMBINANT MALARIA INVASION LIGAND PROTEIN VACCINE
    B Sim; Fiscal Year: 2001
    ..Pf invades erythrocytes (RBCs) by attaching to surface receptors, one of which includes sialic acids on glycophorinA...
  29. MECHANISMS OF THE VOLTAGE-DEPENDENT SODIUM CHANNEL
    S Levinson; Fiscal Year: 2000
    ..Specifically, it has been shown that the removal of sialic acids from channels results in a reduction in the voltage and calcium sensitivity of sodium channel gating...
  30. 9-0 ACETYLATED SIALIC ACIDS ON T CELLS
    Laura Martin; Fiscal Year: 2002
    Our long term goal is to elucidate the role of 9-O-acetylated sialic acids in T cells, both in normal physiology and in the setting of immune-mediated diseases and malignancy...
  31. GLYCOCONJUGATES IN VIRAL PATHOGENESIS
    GILLIAN AIR; Fiscal Year: 2007
    ..Influenza viruses bind to sialic acids through the viral hemagglutmin glyeoprotein (HA), and new virions are released by the sialidase activity of the ..
  32. Dietary Modulation of Sialic Acid Modifications
    Eric I Park; Fiscal Year: 2010
    b>Sialic acids are a diverse family of carbohydrate moieties that are common modifications found on proteins and lipids. Serum sialoproteins are important mediators of inflammation, a process that has been linked to colon cancer...
  33. GLYCOTRANSFERASES AND COLORECTAL CANCER METASTASIS
    Peter Thomas; Fiscal Year: 1999
    ..from human colorectal cancer cell lines in nude mouse models is related to the presence of 1) Cell surface sialic acids, 2) alpha2,6 sialyltransferase activity, and 3) that inhibitors of sialic acid incorporation will inhibit ..
  34. Sialic Acid O-Acetylation in GBS Pathogenesis & Immunity
    Victor Nizet; Fiscal Year: 2010
    ..expertise in GBS molecular genetics and pathogenesis, GBS epidemiology, the biochemistry and cell biology of sialic acids, and the glycobiology of bacterial capsules to comprehensively address the significance of the discovery of CPS ..
  35. ANALYSIS OF THE 85-KD SIALIDASE FAMILY OF T CRUZI
    Stuart Kahn; Fiscal Year: 1992
    ..Specifically, the effect on cell surface sialic acids of granulocytes, monocytes, macrophages, lymphocytes, and high endothelial venules will be studied...
  36. Comparative Study of Influenza Vaccines in Adults
    ARNOLD MONTO; Fiscal Year: 2006
    ..Results will help to determine how the vaccine may be used as part of the strategy to combat influenza in varying situations. [unreadable] [unreadable]..
  37. Reducing Transmission of Influenza by Face Masks
    ARNOLD MONTO; Fiscal Year: 2008
    ..Such a reduction could have a major public health impact during a pandemic. In the second year, the study can be expanded or modified based on findings in the first. ..
  38. NUCLEOTIDE DONORS AFFECTING GLYCOSYLATION PATHWAYS
    Ajit Varki; Fiscal Year: 2003
    ....
  39. Mechanisms of influenza NA drug resistance
    Jennifer L McKimm Breschkin; Fiscal Year: 2010
    ....
  40. A Rapid Immunoassay for Detection of Yersinia Pathogens
    John Glass; Fiscal Year: 2002
    ..Furthermore, this prototype assay will be reduced to a production model, validated for regulatory approval, and finalized for manufacture through a joint venture partner. ..
  41. Unique Neisseria Meningitidis B Capsular Epitopes
    GREGORY MOE; Fiscal Year: 2009
    ..Thus, this proposal offers a novel approach to develop a protective PS-based vaccine that avoids safety concerns of eliciting autoantibodies and for understanding structural differences between group B capsular and host PSA antigens. ..
  42. LECTIN-LIKE PROPERTIES OF AMELOGENINS
    RAJESWARI RAVINDRANATH; Fiscal Year: 2004
    ..These experiments are a logical extension of the newly identified lectin-like properties of amelogenins (Ravindranath et al. Submitted), which are postulated to play a functional role in normal enamel biomineralization. ..
  43. MIMETICS OF CAPSULAR EPITOPES OF NEISSERIA MENINGITIDIS
    GREGORY MOE; Fiscal Year: 2004
    ..The results also may identify new candidate molecules for inclusion in a future vaccine for prevention of NmB disease. ..
  44. Biliary oxysterols and cholangiocarcinoma
    RAHUL P KUVER; Fiscal Year: 2010
    ..abstract_text> ..
  45. Cortical Plasticity after Hemispherectomy
    Gary Mathern; Fiscal Year: 2006
    ..abstract_text> ..
  46. VIRAL EVASION AND HIV ENTRY-BLOCKING STRATEGIES
    Dennis Burton; Fiscal Year: 2004
    ..The studies will reveal how HIV-1 can evade entry-blocking strategies, and may provide important information for vaccine design. ..
  47. Nontypeable Haemophilus influenzae & host cell signaling
    WILLIAM SWORDS; Fiscal Year: 2003
    ..abstract_text> ..
  48. MEASLES VIRUS AND ITS CELLULAR RECEPTOR CD46
    Thilo Stehle; Fiscal Year: 2003
    ..They are also likely to provide insights into strategies for vaccine and drug design against paramyxoviruses such as respiratory syncytial virus in general. ..
  49. Role of hyaluronan in developing and adult CNS
    Yu Yamaguchi; Fiscal Year: 2005
    ..The insight derived from these studies could lead to the development of hyaluronan based therapeutic approaches for neurodegenerative and demyelinating diseases. ..
  50. A SARS-CoV Spike Protein Vaccine
    B Sim; Fiscal Year: 2005
    ..abstract_text> ..
  51. Biofilm formation by Neisseria gonorrhoeae
    Michael A Apicella; Fiscal Year: 2010
    ..This will be accomplished by studying the subproteomes of the cytoplasmic fraction, inner and outer membranes. ..
  52. Regulation of Signal Transduction on Vesicles
    Hung Teh Kao; Fiscal Year: 2007
    ..The results will contribute not only to a better understanding of the molecular basis of neural development, but could also provide insights into the pharmacological treatment of neuropsychiatric diseases. ..
  53. Development of Guinea Pig as Mamalian for Influenza Virus Transmission
    Peter Palese; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  54. STUDY OF FC RECEPTOR GENES: MACROPHAGES AND LYMPHOCYTES
    Jeffrey Ravetch; Fiscal Year: 2007
    ..unreadable]..
  55. Glycosaminoglycan-Protein Binding
    Joseph Zaia; Fiscal Year: 2006
    ..abstract_text> ..
  56. Plasmodium vivax recombinant CS protein vaccine
    B Sim; Fiscal Year: 2006
    ..abstract_text> ..
  57. COOPERATIVE HUMORAL & CELLULAR IMMUNITY AGAINST HIV/SIV
    Dennis Burton; Fiscal Year: 2005
    ..This will provide us with the first opportunity to look at the effects of potent human mAbs on established infection in the presence of functional T cells. ..
  58. TRANSFECTANT INFLUENZA VIRUSES IN CANCER THERAPY
    Adolfo Garcia Sastre; Fiscal Year: 2002
    ..The proposed research may advance the field of cancer therapy towards possible novel ways to treat human tumors and prolong survival of cancer patients. ..