ascorbic acid

Summary

Summary: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.

Top Publications

  1. ncbi Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis
    Goran Bjelakovic
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    JAMA 297:842-57. 2007
  2. pmc Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells
    Matthias Stadtfeld
    Massachusetts General Hospital Center for Regenerative Medicine, Harvard Stem Cell Institute, Boston, Massachusetts, USA
    Nat Genet 44:398-405, S1-2. 2012
  3. ncbi Dietary ascorbate intake affects steady state tissue concentrations in vitamin C-deficient mice: tissue deficiency after suboptimal intake and superior bioavailability from a food source (kiwifruit)
    Margreet C M Vissers
    Free Radical Research Group, University of Otago, Christchurch, New Zealand
    Am J Clin Nutr 93:292-301. 2011
  4. pmc Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues
    Qi Chen
    Molecular and Clinical Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:13604-9. 2005
  5. ncbi Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals
    Ruichuan Yin
    The State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    J Am Chem Soc 135:10396-403. 2013
  6. pmc Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 300:2123-33. 2008
  7. pmc Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice
    Christopher P Corpe
    Molecular and Clinical Nutrition Section, Digestive Diseases Branch, Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, NIH, Bethesda, Maryland, USA
    J Clin Invest 120:1069-83. 2010
  8. pmc A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Arch Intern Med 167:1610-8. 2007
  9. ncbi Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes
    Tomosaburo Takahashi
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 107:1912-6. 2003
  10. ncbi Effect of ascorbic acid intake on nonheme-iron absorption from a complete diet
    J D Cook
    Department of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Am J Clin Nutr 73:93-8. 2001

Detail Information

Publications379 found, 100 shown here

  1. ncbi Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis
    Goran Bjelakovic
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    JAMA 297:842-57. 2007
    ..Antioxidant supplements are used for prevention of several diseases...
  2. pmc Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells
    Matthias Stadtfeld
    Massachusetts General Hospital Center for Regenerative Medicine, Harvard Stem Cell Institute, Boston, Massachusetts, USA
    Nat Genet 44:398-405, S1-2. 2012
    ..Here, we show that reprogramming in the presence of ascorbic acid attenuates hypermethylation of Dlk1-Dio3 by enabling a chromatin configuration that interferes with binding of ..
  3. ncbi Dietary ascorbate intake affects steady state tissue concentrations in vitamin C-deficient mice: tissue deficiency after suboptimal intake and superior bioavailability from a food source (kiwifruit)
    Margreet C M Vissers
    Free Radical Research Group, University of Otago, Christchurch, New Zealand
    Am J Clin Nutr 93:292-301. 2011
    ..How dietary intake affects tissue concentrations is difficult to monitor and has generally been based on the measurement of plasma concentrations...
  4. pmc Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues
    Qi Chen
    Molecular and Clinical Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:13604-9. 2005
    Human pharmacokinetics data indicate that i.v. ascorbic acid (ascorbate) in pharmacologic concentrations could have an unanticipated role in cancer treatment...
  5. ncbi Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals
    Ruichuan Yin
    The State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    J Am Chem Soc 135:10396-403. 2013
    ..Here, we demonstrate that a vital nutrient ascorbic acid (AA), or vitamin C (Vc), can directly enhance the catalytic activity of Tet dioxygenases for the oxidation of ..
  6. pmc Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 300:2123-33. 2008
    ..However, few long-term trials have evaluated men at initially low risk of cardiovascular disease, and no previous trial in men has examined vitamin C alone in the prevention of cardiovascular disease...
  7. pmc Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice
    Christopher P Corpe
    Molecular and Clinical Nutrition Section, Digestive Diseases Branch, Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, NIH, Bethesda, Maryland, USA
    J Clin Invest 120:1069-83. 2010
    ..These findings indicate a key role for Slc23a1 in renal ascorbate absorption and perinatal survival and reveal regulation of vitamin C biosynthesis in mice...
  8. pmc A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Arch Intern Med 167:1610-8. 2007
    ..Few trials have examined interactions among antioxidants, and, to our knowledge, no previous trial has examined the individual effect of ascorbic acid (vitamin C) on CVD.
  9. ncbi Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes
    Tomosaburo Takahashi
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 107:1912-6. 2003
    ..In appropriate culture conditions, ES cells can differentiate into specialized cells, including cardiac myocytes, but the efficiency is typically low and the process is incompletely understood...
  10. ncbi Effect of ascorbic acid intake on nonheme-iron absorption from a complete diet
    J D Cook
    Department of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Am J Clin Nutr 73:93-8. 2001
    b>Ascorbic acid has a pronounced enhancing effect on the absorption of dietary nonheme iron when assessed by feeding single meals to fasting subjects...
  11. pmc Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials
    Stephen P Juraschek
    Johns Hopkins School of Medicine, Johns Hopkins Bloomberg School of Public Health, and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Am J Clin Nutr 95:1079-88. 2012
    ..However, evidence for blood pressure-lowering effects of vitamin C in clinical trials is inconsistent...
  12. ncbi SVCT1 and SVCT2: key proteins for vitamin C uptake
    I Savini
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Amino Acids 34:347-55. 2008
    ..Regulation at mRNA or protein level may serve for preferential accumulation of ascorbic acid at sites where it is needed...
  13. ncbi A family of mammalian Na+-dependent L-ascorbic acid transporters
    H Tsukaguchi
    Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 399:70-5. 1999
    Vitamin C (L-ascorbic acid) is essential for many enzymatic reactions, in which it serves to maintain prosthetic metal ions in their reduced forms (for example, Fe2+, Cu+), and for scavenging free radicals in order to protect tissues ..
  14. pmc Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer
    Daniel A Monti
    Myrna Brind Center of Integrative Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e29794. 2012
    Preclinical data support further investigation of ascorbic acid in pancreatic cancer. There are currently insufficient safety data in human subjects, particularly when ascorbic acid is combined with chemotherapy.
  15. ncbi Dietary vitamin C and E modulates oxidative stress induced-kidney and lens injury in diabetic aged male rats through modulating glucose homeostasis and antioxidant systems
    Dilek Ozkaya
    Deparment of Ophthalmology, Medical Faculty, Suleyman Demirel University, Isparta, Turkey
    Cell Biochem Funct 29:287-93. 2011
    ..VCE ameliorated also diabetes-induced histopathological changes in kidney. In conclusion, we observed that VCE supplementation is beneficial towards kidney and lens of aged diabetic rats by modulating oxidative and antioxidant systems...
  16. pmc Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice
    Ester Zito
    University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Cambridge, UK
    Mol Cell 48:39-51. 2012
    ..Tissue ascorbic acid content was lower in mutant mice, and ascorbic acid supplementation improved procollagen maturation and ..
  17. pmc The missing step of the L-galactose pathway of ascorbate biosynthesis in plants, an L-galactose guanyltransferase, increases leaf ascorbate content
    William A Laing
    Horticultural and Food Research Institute of New Zealand, PB 92160, Auckland 1142, New Zealand
    Proc Natl Acad Sci U S A 104:9534-9. 2007
    ..enzyme that converts GDP-L-galactose to L-galactose-1-phosphate is unknown in the L-galactose pathway of ascorbic acid biosynthesis and a possible candidate identified through map-based cloning is the uncharacterized gene ..
  18. ncbi Authors' perspective: What is the optimum intake of vitamin C in humans?
    Balz Frei
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Crit Rev Food Sci Nutr 52:815-29. 2012
    ....
  19. ncbi Vitamin C suppresses TNF alpha-induced NF kappa B activation by inhibiting I kappa B alpha phosphorylation
    Juan M Carcamo
    Program in Molecular Pharmacology and Chemistry and Department of Clinical Chemistry, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 451, New York, New York 10021, USA
    Biochemistry 41:12995-3002. 2002
    ..Vitamin C is an important antioxidant, and most cells accumulate ascorbic acid (AA) intracellularly by transporting the oxidized form of the vitamin, dehydroascorbic acid (DHA)...
  20. ncbi Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase
    Nermin Kuzkaya
    Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:22546-54. 2003
    ..We confirmed that ONOO- uncouples eNOS by oxidation of tetrahydrobiopterin and that ascorbate does not fully protect BH4 from oxidation but recycles BH3. radical back to BH4...
  21. ncbi Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man
    M Nishikimi
    Institute of Applied Biochemistry, Yagi Memorial Park, Gifu, Japan
    J Biol Chem 269:13685-8. 1994
    Man is among the exceptional higher animals that are unable to synthesize L-ascorbic acid because of their deficiency in L-gulono-gamma-lactone oxidase, the enzyme catalyzing the terminal step in L-ascorbic acid biosynthesis...
  22. ncbi GDP-D-mannose 3,5-epimerase (GME) plays a key role at the intersection of ascorbate and non-cellulosic cell-wall biosynthesis in tomato
    Louise Gilbert
    Institut National de la Recherche Agronomique INRA, Universite de Bordeaux, Unité Mixte de Recherche 619 sur la Biologie du Fruit, Institut Fédératif de Recherche 103, BP 81, F 33883 Villenave d Ornon Cedex, France
    Plant J 60:499-508. 2009
    ....
  23. ncbi Reduction of graphene oxide via L-ascorbic acid
    Jiali Zhang
    National Key Laboratory of Micro Nano Fabrication Technology, Research Institute of Micro Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, PR China
    Chem Commun (Camb) 46:1112-4. 2010
    We demonstrated that the individual graphene oxide sheets can be readily reduced under a mild condition using L-ascorbic acid (L-AA)...
  24. pmc Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy
    Yoshitaka Kondo
    Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Proc Natl Acad Sci U S A 103:5723-8. 2006
    ..The lactonase reaction with l-gulono-gamma-lactone is the penultimate step in l-ascorbic acid (AA) biosynthesis, and the essential role of SMP30 in this synthetic process was verified here by a ..
  25. pmc Antioxidants prevent health-promoting effects of physical exercise in humans
    Michael Ristow
    Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena D 07743, Germany
    Proc Natl Acad Sci U S A 106:8665-70. 2009
    ..Supplementation with antioxidants may preclude these health-promoting effects of exercise in humans...
  26. ncbi The role of L-ascorbic acid recycling in responding to environmental stress and in promoting plant growth
    Daniel R Gallie
    Department of Biochemistry, University of California, Riverside, CA 92521 0129, USA
    J Exp Bot 64:433-43. 2013
    L-Ascorbic acid (Asc) is the most abundant water-soluble antioxidant in plants. It serves as a cofactor for enzymes involved in photosynthesis, hormone biosynthesis, and the regeneration of antioxidants such as α-tocopherol...
  27. pmc Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations
    Anitra C Carr
    Centre for Free Radical Research, Department of Pathology, University of Otago, Christchurch, Christchurch, New Zealand
    Am J Clin Nutr 97:800-7. 2013
    ..Vitamin C may also protect these metabolically active cells from oxidative stress...
  28. ncbi Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials
    Jens Lykkesfeldt
    Department of Disease Biology, University of Copenhagen, Denmark
    Br J Nutr 103:1251-9. 2010
    ..The present review discusses the relevance of the available literature on vitamin C supplementation and proposes guidelines for future randomised intervention trials...
  29. pmc Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries
    Mark Levine
    Molecular and Clinical Nutrition Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1372, USA
    Adv Nutr 2:78-88. 2011
    ..The effects of pharmacologic ascorbate should be further studied in diseases, such as cancer and infections, which may respond to generation of reactive oxygen species via H(2)O(2)...
  30. pmc Ascorbic acid: chemistry, biology and the treatment of cancer
    Juan Du
    Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, IA, USA
    Biochim Biophys Acta 1826:443-57. 2012
    ..Both the names ascorbic acid and vitamin C reflect its antiscorbutic properties due to its role in the synthesis of collagen in connective ..
  31. ncbi Human vitamin C (L-ascorbic acid) transporter SVCT1
    Y Wang
    Membrane Biology Program and Renal Division, Department of Pathology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Biochem Biophys Res Commun 267:488-94. 2000
    In human, vitamin C (l-ascorbic acid) is an essential micronutrient required for an array of biological functions including enzymatic reactions and antioxidation...
  32. pmc Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against paraquat-induced oxidative damage in lung
    Fiona Edith Harrison
    Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 7:e35623. 2012
    ..The SVCT2-Tg mouse shows increased SVCT2 mRNA levels in all organs tested and correspondingly increased ascorbic acid (ASC) levels in all organs except liver...
  33. pmc Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer
    Michael Graham Espey
    Molecular and Clinical Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 50:1610-9. 2011
    ..These data support the testing of pharmacologic ascorbate in adjunctive treatments for cancers prone to high failure rates with conventional therapeutic regimens, such as pancreatic cancer...
  34. pmc Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2
    Fiona E Harrison
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6303, USA
    Free Radic Biol Med 46:719-30. 2009
    ....
  35. ncbi Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells
    Helen J Knowles
    Cancer Research United Kingdom Molecular Oncology Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS
    Cancer Res 63:1764-8. 2003
    ..These results indicate that both ascorbate and iron availability have major effects on HIF, and imply that the system is commonly regulated by limiting hydroxylase activity under normoxic tissue culture conditions...
  36. ncbi Relations of serum ascorbic acid and alpha-tocopherol to diabetic retinopathy in the Third National Health and Nutrition Examination Survey
    Amy E Millen
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison 53705 2397, USA
    Am J Epidemiol 158:225-33. 2003
    The protective relation of ascorbic acid and alpha-tocopherol to the development of diabetic retinopathy has not been thoroughly evaluated in epidemiologic studies...
  37. pmc Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells
    Nan Cao
    Key Laboratory of Stem Cell Biology, Shanghai Institutes for Biological Sciences SIBS, Chinese Academy of Sciences CAS and Shanghai Jiao Tong University School of Medicine SJTUSM, Shanghai, China
    Cell Res 22:219-36. 2012
    ..we systematically screened sixteen cardiomyocyte inducers on various murine (m) iPSCs and found that only ascorbic acid (AA) consistently and robustly enhanced the cardiac differentiation of eleven lines including eight without ..
  38. pmc Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing
    Iratxe Eskurza
    Department of Integrative Physiology, University of Colorado at Boulder, UCB 354, Boulder, CO 80309, USA
    J Physiol 556:315-24. 2004
    ..Brachial artery flow-mediated dilatation was determined at baseline and after ascorbic acid (vitamin C) intravenous infusion and chronic supplementation (500 mg day(-1) for 30 days) in three groups of ..
  39. ncbi Vitamin C. Biosynthesis, recycling and degradation in mammals
    Carole L Linster
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Brussels, Belgium
    FEBS J 274:1-22. 2007
    ..The last step in the pathway of vitamin C synthesis is the oxidation of l-gulonolactone to l-ascorbic acid by l-gulonolactone oxidase, an enzyme associated with the endoplasmic reticulum membrane and deficient in man, ..
  40. pmc Expression profiling of ascorbic acid-related genes during tomato fruit development and ripening and in response to stress conditions
    Eugenia Ioannidi
    Group of Biotechnology of Pharmaceutical Plants, Division of Pharmacognosy Pharmacology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece
    J Exp Bot 60:663-78. 2009
    ..The data suggest that L-galactose-1-phosphate phosphatase could play an important role in regulating ascorbic acid accumulation during tomato fruit development and ripening.
  41. ncbi The biosynthetic pathway of vitamin C in higher plants
    G L Wheeler
    School of Biological Sciences, University of Exeter, Hatherly Laboratories, UK
    Nature 393:365-9. 1998
    Vitamin C (L-ascorbic acid) has important antioxidant and metabolic functions in both plants and animals, but humans, and a few other animal species, have lost the capacity to synthesize it...
  42. ncbi Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival
    Sotiria Sotiriou
    Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Med 8:514-7. 2002
    The only proven requirement for ascorbic acid (vitamin C) is in preventing scurvy, presumably because it is a cofactor for hydroxylases required for post-translational modifications that stabilize collagen...
  43. ncbi Those confounded vitamins: what can we learn from the differences between observational versus randomised trial evidence?
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, UK
    Lancet 363:1724-7. 2004
  44. pmc Immunocytochemical determination of the subcellular distribution of ascorbate in plants
    Bernd Zechmann
    Institute of Plant Sciences, University of Graz, Schubertstrasse 51, Graz, Austria
    Planta 233:1-12. 2011
    ..First, preadsorption of the ascorbate antisera with ascorbic acid or dehydroascorbic acid resulted in the reduction of the labeling to background levels...
  45. ncbi 6-Bromo-6-deoxy-L-ascorbic acid: an ascorbate analog specific for Na+-dependent vitamin C transporter but not glucose transporter pathways
    Christopher P Corpe
    Molecular and Clinical Nutrition Section, Digestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892 1372, USA
    J Biol Chem 280:5211-20. 2005
    ..As a new step to resolve this issue, we identified and tested 6-bromo-6-deoxy-L-ascorbic acid as a specific candidate for SVCTs...
  46. pmc Antioxidant vitamins and their use in preventing cardiovascular disease
    Dan Farbstein
    Technion Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Molecules 15:8098-110. 2010
    ..We provide one example of how pharmacogenomics may be used to identify a sub-population which may indeed benefit from antioxidant supplementation...
  47. ncbi Gold kiwifruit consumed with an iron-fortified breakfast cereal meal improves iron status in women with low iron stores: a 16-week randomised controlled trial
    Kathryn Beck
    Institute of Food, Nutrition and Human Health, Massey University, Private Bag 102 904, North Shore Mail Centre, 0745 Auckland, New Zealand
    Br J Nutr 105:101-9. 2011
    b>Ascorbic acid, and more recently, the carotenoids lutein and zeaxanthin have been shown to enhance Fe absorption...
  48. pmc Low levels of vitamin C in dialysis patients is associated with decreased prealbumin and increased C-reactive protein
    Kunying Zhang
    Renal Division, Department of Medicine, Peking University First Hospital, Peking, PR China
    BMC Nephrol 12:18. 2011
    ..We hypothesized that vitamin C had anti-inflammation effect because of its electron offering ability. The current study was designed to test the relationship of plasma vitamin C level and some inflammatory markers...
  49. ncbi Paraquat-induced oxidative stress in drosophila melanogaster: effects of melatonin, glutathione, serotonin, minocycline, lipoic acid and ascorbic acid
    Ernesto Bonilla
    Neurochemistry Section, Instituto de Investigaciones Clinicas Dr Americo Negrette, Universidad del Zulia, Apartado 23, Maracaibo, Venezuela
    Neurochem Res 31:1425-32. 2006
    The efficacy of melatonin, glutathione, serotonin, minocycline, lipoic acid and ascorbic acid in counteracting the toxicity of paraquat in Drosophila melanogaster was examined...
  50. ncbi Decreased expression of the vitamin C transporter SVCT1 by ascorbic acid in a human intestinal epithelial cell line
    Lauren MacDonald
    Centre for Nutrition and Food Safety, School of Biomedical and Life Sciences, University of Surrey, Guildford, UK
    Br J Nutr 87:97-100. 2002
    Vitamin C (ascorbic acid) is an essential nutrient that is involved in a number of cellular processes. However, unlike most mammals, man is unable to synthesize vitamin C and it must therefore be acquired from the diet...
  51. pmc Breathing-in epigenetic change with vitamin C
    Asun Monfort
    Wellcome Trust, Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    EMBO Rep 14:337-46. 2013
    ..The available data suggest a link between dioxygenase function and stem cell differentiation, which is exposed to environmental influence and is relevant for human disease...
  52. ncbi Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function
    Alexander J Michels
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Annu Rev Nutr 33:45-70. 2013
    ..We conclude that future epidemiological studies should take into account genetic variation in order to successfully determine the role of vitamin C nutriture or supplementation in human vitamin C status and chronic disease risk. ..
  53. ncbi Vitamin C pharmacokinetics: implications for oral and intravenous use
    Sebastian J Padayatty
    National Institute of Diabetes and Digestive and Kidney Diseases, the National Cancer Institut, and the Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1372, USA
    Ann Intern Med 140:533-7. 2004
    ..Early clinical studies of vitamin C in patients with terminal cancer suggested clinical benefit, but 2 double-blind, placebo-controlled trials showed none. However, these studies used different routes of administration...
  54. ncbi Plasma concentrations of ascorbic acid and C-reactive protein, and risk of future coronary artery disease, in apparently healthy men and women: the EPIC-Norfolk prospective population study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Br J Nutr 96:516-22. 2006
    High plasma concentrations of ascorbic acid, a marker of fruit and vegetable intake, are associated with low risk of coronary artery disease. Whether this relationship is explained by a reduction in systemic inflammation is unclear...
  55. ncbi L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin
    R Heller
    Center of Vascular Biology and Medicine, Friedrich Schiller University of Jena, D 99089 Erfurt, Germany
    J Biol Chem 276:40-7. 2001
    b>Ascorbic acid has been shown to stimulate endothelial nitric oxide (NO) synthesis in a time- and concentration-dependent fashion without affecting NO synthase (NOS) expression or l-arginine uptake...
  56. ncbi Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition
    K T Khaw
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, UK
    Lancet 357:657-63. 2001
    b>Ascorbic acid (vitamin C) might be protective for several chronic diseases. However, findings from prospective studies that relate ascorbic acid to cardiovascular disease or cancer are not consistent...
  57. pmc Low vitamin C and increased oxidative stress and cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2
    F E Harrison
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 49:821-9. 2010
    ....
  58. pmc Effects of vitamins C and E and beta-carotene on the risk of type 2 diabetes in women at high risk of cardiovascular disease: a randomized controlled trial
    Yiqing Song
    Division of Preventive Medicine and Cardiology Division, Harvard School of Public Health, Boston, MA 02215, USA
    Am J Clin Nutr 90:429-37. 2009
    ..Vitamin C, vitamin E, and beta-carotene are major antioxidants and as such may protect against the development of type 2 diabetes via reduction of oxidative stress...
  59. ncbi Failure of ascorbic acid to prevent contrast-media induced nephropathy in patients with renal dysfunction
    A Boscheri
    Department of Internal Medicine and Cardiology, University of Technology, Dresden, Germany
    Clin Nephrol 68:279-86. 2007
    ..We sought to evaluate the efficacy of the antioxidant ascorbic acid as an adjunct to hydration in limiting the incidence of contrast induced nephrotoxicity after coronary ..
  60. ncbi Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects
    Julien Verrax
    PMNT Unit, Louvain Drug Research Institute, Universite Catholique de Louvain, 1200 Bruxelles, Belgium
    Free Radic Biol Med 47:32-40. 2009
    ..Taken together, these results confirm that oral and parenteral administration of ascorbate are not comparable, the latter resulting in pharmacologic concentrations of ascorbate that exhibit interesting anticancer properties...
  61. pmc A randomized steady-state bioavailability study of synthetic versus natural (kiwifruit-derived) vitamin C
    Anitra C Carr
    Centre for Free Radical Research, Department of Pathology and Biomedical Science, University of Otago, Christchurch, PO Box 4345, Christchurch 8140, New Zealand
    Nutrients 5:3684-95. 2013
    ..Overall, our study showed comparable bioavailability of synthetic and kiwifruit-derived vitamin C. ..
  62. ncbi Enhancing ascorbate in fruits and tubers through over-expression of the L-galactose pathway gene GDP-L-galactose phosphorylase
    Sean Bulley
    The New Zealand Institute for Plant and Food Research Limited, Auckland, New Zealand
    Plant Biotechnol J 10:390-7. 2012
    ..In both strawberry and tomato, an increase in polyphenolic content was associated with increased ascorbate. These results show that GGP can be used to raise significantly ascorbate concentration in commercially significant edible crops...
  63. pmc Candidate genes and quantitative trait loci affecting fruit ascorbic acid content in three tomato populations
    Rebecca Stevens
    Institut National de la Recherche Agronomique, UR1052, Unité de Génétique et Amélioration des Fruits et Légumes, Domaine St Maurice BP94, 84143 Montfavet, France
    Plant Physiol 143:1943-53. 2007
    Fresh fruit and vegetables are a major source of ascorbic acid (vitamin C), an important antioxidant for the human diet and also for plants. Ascorbic acid content in fruit exhibits a quantitative inheritance...
  64. pmc The ascorbic acid content of tomato fruits is associated with the expression of genes involved in pectin degradation
    Antonio Di Matteo
    Department of Soil, Plant, Environment and Animal Sciences, University of Naples Federico II, Via Universita 100, 80055 Portici, Italy
    BMC Plant Biol 10:163. 2010
    High levels of ascorbic acid (AsA) in tomato fruits provide health benefits for humans and also play an important role in several aspects of plant life...
  65. pmc The transcription factor ABI4 Is required for the ascorbic acid-dependent regulation of growth and regulation of jasmonate-dependent defense signaling pathways in Arabidopsis
    Pavel I Kerchev
    Centre for Plant Sciences, Faculty of Biology, University of Leeds, Leeds LS2 9JT, UK
    Plant Cell 23:3319-34. 2011
    ..characterized in the Arabidopsis thaliana vitamin c defective1 (vtc1) and vtc2 mutants, which are defective in ascorbic acid synthesis and show a slow growth phenotype together with enhanced abscisic acid (ABA) levels relative to the ..
  66. pmc Vitamin C: update on physiology and pharmacology
    J Mandl
    Department of Medical Chemistry, Molecular Biology and Patobiochemistry, Semmelweis University Budapest, Budapest, Hungary
    Br J Pharmacol 157:1097-110. 2009
    Although ascorbic acid is an important water-soluble antioxidant and enzyme cofactor in plants and animals, humans and some other species do not synthesize ascorbate due to the lack of the enzyme catalyzing the final step of the ..
  67. ncbi Pharmacokinetics of vitamin C: insights into the oral and intravenous administration of ascorbate
    Jorge Duconge
    Department of Pharmaceutical Sciences, Suite 413C, School of Pharmacy, Medical Sciences Campus, University of Puerto Rico, PO Box 365067, San Juan, PR 00936 5067
    P R Health Sci J 27:7-19. 2008
    ..This review describes the current state-of-the-art in oral and intravenous vitamin C pharmacokinetics. In addition, the governmental recommendations of dose and frequency of vitamin C intake will also be addressed...
  68. pmc HIF-dependent antitumorigenic effect of antioxidants in vivo
    Ping Gao
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cancer Cell 12:230-8. 2007
    ..These findings challenge the paradigm that antioxidants diminish tumorigenesis primarily through decreasing DNA damage and mutations and provide significant support for a key antitumorigenic effect of diminishing HIF levels...
  69. ncbi Ascorbic acid: metabolism and functions of a multi-facetted molecule
    N Smirnoff
    Hatherly Laboratories, School of Biological Sciences, University of Exeter, UK
    Curr Opin Plant Biol 3:229-35. 2000
    b>Ascorbic acid (vitamin C) is the most abundant antioxidant in plants...
  70. ncbi Ascorbic acid supplementation could affect passive avoidance learning and memory in rat
    Siamak Shahidi
    Department of Physiology, Hamadan University of Medical Sciences, Hamedan, Iran
    Brain Res Bull 76:109-13. 2008
    b>Ascorbic acid (vitamin C) is required for health and, in particular, its supplementation has beneficial effects in some pathological conditions...
  71. pmc Translocation and the alternative D-galacturonate pathway contribute to increasing the ascorbate level in ripening tomato fruits together with the D-mannose/L-galactose pathway
    Adebanjo Ayobamidele Badejo
    Department of Applied Bioscience and Biotechnology, Faculty of Life and Environmental Science, Shimane University, 1060 Nishikawatsu, Matsue, Shimane 690 8504, Japan
    J Exp Bot 63:229-39. 2012
    The D-mannose/L-galactose pathway for the biosynthesis of vitamin C (L-ascorbic acid; AsA) has greatly improved the understanding of this indispensable compound in plants, where it plays multifunctional roles...
  72. ncbi Comparison of the total phenolic and ascorbic acid content of freeze-dried and air-dried marionberry, strawberry, and corn grown using conventional, organic, and sustainable agricultural practices
    Danny K Asami
    Department of Food Science and Technology, University of California Davis, 95616, USA
    J Agric Food Chem 51:1237-41. 2003
    ..In all samples, freeze-drying preserved higher levels of TPs in comparison with air-drying...
  73. ncbi Plasma concentrations of carotenoids and vitamin C are better correlated with dietary intake in normal weight than overweight and obese elderly subjects
    Jesus Vioque
    Departamento Salud Pública, Campus San Juan, Universidad Miguel Hernandez, Elche Alicante, Ctra Valencia s n, 03550 Alicante, Spain
    Br J Nutr 97:977-86. 2007
    ..The present data suggest that plasma carotenoids and vitamin C may be good markers of dietary intake in elderly subjects, but not so for alpha-carotene, beta-carotene and lutein + zeaxanthin in obese subjects...
  74. ncbi Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise
    A Childs
    Biochemistry of Aging Laboratory, Center for Exercice Science, College of Human Performance, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 31:745-53. 2001
    ..This acute human inflammatory model strongly suggests that vitamin C and NAC supplementation immediately post-injury, transiently increases tissue damage and oxidative stress...
  75. ncbi Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participants of the European Prospective Investigation into Cancer Norfolk prospective population study
    Phyo K Myint
    Department of Public Health and Primary Care, University of Cambridge, United Kingdom
    Am J Clin Nutr 87:64-9. 2008
    ..Although clinical trials showed no significant benefit of vitamin C supplementation in reducing stroke risk, they were not able to examine the relation between plasma vitamin C concentrations and stroke risk in a general population...
  76. ncbi Protective effect of vitamin C on 8-hydroxy-2'-deoxyguanosine level in peripheral blood lymphocytes of chronic hemodialysis patients
    Der Cherng Tarng
    Faculty of Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
    Kidney Int 66:820-31. 2004
    ....
  77. ncbi Engineering increased vitamin C levels in plants by overexpression of a D-galacturonic acid reductase
    Fernanda Agius
    Departamento de Biologia Molecular y Bioquimica, Universidad de Malaga, 29071 Malaga, Spain
    Nat Biotechnol 21:177-81. 2003
    L-Ascorbic acid (vitamin C) in fruits and vegetables is an essential component of human nutrition. Surprisingly, only limited information is available about the pathway(s) leading to its biosynthesis in plants...
  78. ncbi A pilot clinical study of continuous intravenous ascorbate in terminal cancer patients
    Hugh D Riordan
    Biocommunication Research Institute, Center for the Improvement of Human Functioning, 3100 North Hillside Avenue, Wichita, KS 67219, USA
    P R Health Sci J 24:269-76. 2005
    ..These data suggest that intravenous vitamin C therapy for cancer is relatively safe, provided the patient does not have a history of kidney stone formation...
  79. ncbi Effect of high dose vitamin C supplementation on muscle soreness, damage, function, and oxidative stress to eccentric exercise
    S C Bryer
    Exercise and Sport Science Dept, University of North Carolina Greensboro, 27402 6170, USA
    Int J Sport Nutr Exerc Metab 16:270-80. 2006
    ..These data suggest that vitamin C pretreatment can reduce MS, delay CK increase, and prevent blood glutathione oxidation with little influence on muscle function loss...
  80. ncbi Changes in oxidative processes and components of the antioxidant system during tomato fruit ripening
    Ana Jimenez
    John Innes Centre, Norwich Research Park, Colney, UK
    Planta 214:751-8. 2002
    ..Changes in the activities of superoxide dismutase, catalase and the enzymes involved in the ascorbate-glutathione cycle during ripening indicated that the antioxidative system plays a fundamental role in the ripening of tomato fruits...
  81. ncbi Phase I clinical trial of i.v. ascorbic acid in advanced malignancy
    L J Hoffer
    Montreal Centre for Experimental Therapeutics in Cancer, Lady Davis Institute for Medical Research, McGill University and the Jewish General Hospital, Montreal, Quebec, Canada
    Ann Oncol 19:1969-74. 2008
    b>Ascorbic acid is a widely used and controversial alternative cancer treatment...
  82. pmc Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells
    Satya S Pathi
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    Nutr Cancer 63:1133-42. 2011
    b>Ascorbic acid (vitamin C) inhibits cancer cell growth, and there is a controversy regarding the cancer chemoprotective effects of pharmacologic doses of this compound that exhibits prooxidant activity...
  83. pmc Low ascorbic acid in the vtc-1 mutant of Arabidopsis is associated with decreased growth and intracellular redistribution of the antioxidant system
    S D Veljovic-Jovanovic
    Center for Multidisciplinary Studies, University of Belgrade, Kneza Viseslava 1a, 11030 Belgrade, Yugoslavia
    Plant Physiol 127:426-35. 2001
    b>Ascorbic acid has numerous and diverse roles in plant metabolism...
  84. ncbi Orange juice improved lipid profile and blood lactate of overweight middle-aged women subjected to aerobic training
    Nancy Preising Aptekmann
    Food and Nutrition Department, Faculty of Pharmaceutical Sciences, Sao Paulo State University UNESP, Araraquara, Brazil
    Maturitas 67:343-7. 2010
    ..This study investigated how consumption of orange juice associated with aerobic training affected serum lipids and physical characteristics of overweight, middle-aged women...
  85. ncbi Haptoglobin genotype modifies the association between dietary vitamin C and serum ascorbic acid deficiency
    Leah E Cahill
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Am J Clin Nutr 92:1494-500. 2010
    ..The capacity of Hp2 to inhibit oxidation and vitamin C depletion is less than that of Hp1, but the influence on vitamin C requirements remains unknown...
  86. pmc Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2
    Anika E Wagner
    Institute of Human Nutrition and Food Science, Christian Albrechts University of Kiel, Germany
    BMC Complement Altern Med 11:1. 2011
    Both resveratrol and vitamin C (ascorbic acid) are frequently used in complementary and alternative medicine...
  87. ncbi Evaluation of antioxidant drugs for the treatment of ochronotic alkaptonuria in an in vitro human cell model
    Laura Tinti
    Sezione di Reumatologia, Dipartimento di Medicina Clinica e Scienze Immunologiche, Universita degli Studi di Siena, Policlinico Le Scotte, Siena, Italy
    J Cell Physiol 225:84-91. 2010
    ..propose a new treatment for AKU using the antioxidant N-acetylcysteine (NAC) administered in combinations with ascorbic acid (ASC) since it has been proven that NAC counteracts the side-effects of ASC...
  88. ncbi Light affects ascorbate content and ascorbate-related gene expression in tomato leaves more than in fruits
    Capucine Massot
    INRA UR 1115 Plantes et Systèmes de Culture Horticoles, Domaine St Paul, Site Agroparc, 84914, Avignon, France
    Planta 235:153-63. 2012
    ..This study provides a new hypothesis on the role of GME1 in addition to VTC2 in light-regulated AsA biosynthesis...
  89. ncbi Lipid peroxidation and antioxidant status in preeclampsia: a systematic review
    Sajal Gupta
    Glickman Urological and Kidney Institute, Cleveland, OH 44195, USA
    Obstet Gynecol Surv 64:750-9. 2009
    ..Preeclampsia is characterized by increased lipid peroxidation and diminished antioxidant capacity; however, there is no consensus as to the extent of these conditions...
  90. pmc Aortic wall damage in mice unable to synthesize ascorbic acid
    N Maeda
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 97:841-6. 2000
    By inactivating the gene for L-gulono-gamma-lactone oxidase, a key enzyme in ascorbic acid synthesis, we have generated mice that, like humans, depend on dietary vitamin C...
  91. ncbi The influence of organic and conventional cultivation systems on the nutritional value and content of bioactive compounds in selected tomato types
    Ewelina Hallmann
    WULS SGGW, Faculty of Human Nutrition and Consumer Sciences, Department of Functional Food and Commodity, Division of Organic Food, Warsaw, Poland
    J Sci Food Agric 92:2840-8. 2012
    ..The experiment was carried out in two growing seasons of 2008 and 2009, and in three organic and three conventional farms...
  92. ncbi Selective ascorbate toxicity in malignant mesothelioma: a redox Trojan mechanism
    Elia Ranzato
    Department of Environment and Life Sciences, DISAV, University of Piemonte Orientale Amedeo Avogadro, Viale T Michel 11, Alessandria, Italy
    Am J Respir Cell Mol Biol 44:108-17. 2011
    ..This explains the selective toxicity of ascorbate in MMe cells, and suggests its possible use in the clinical treatment of malignant mesothelioma...
  93. ncbi Tomato fruit ascorbic acid content is linked with monodehydroascorbate reductase activity and tolerance to chilling stress
    R Stevens
    INRA, UR1052, Unité de Génétique et Amélioration des Fruits et Légumes, Domaine St Maurice BP94, 84143 Montfavet, France
    Plant Cell Environ 31:1086-96. 2008
    ..trait loci (QTL) mapping is a step towards the identification of factors regulating traits such as fruit ascorbic acid content...
  94. pmc Supplementation with vitamins C and E during pregnancy for the prevention of preeclampsia and other adverse maternal and perinatal outcomes: a systematic review and metaanalysis
    Agustin Conde-Agudelo
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Am J Obstet Gynecol 204:503.e1-12. 2011
    ..To determine whether supplementation with vitamins C and E during pregnancy reduces the risk of preeclampsia and other adverse maternal and perinatal outcomes...
  95. ncbi Melatonin and vitamin C increase umbilical blood flow via nitric oxide-dependent mechanisms
    Avnesh S Thakor
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    J Pineal Res 49:399-406. 2010
    ..Fetal NO blockade prevented the increase in umbilical blood flow induced by melatonin or vitamin C. Antioxidant treatment could be a useful clinical tool to increase or maintain umbilical blood flow in complicated pregnancy...
  96. ncbi Overexpression of SlGMEs leads to ascorbate accumulation with enhanced oxidative stress, cold, and salt tolerance in tomato
    Chanjuan Zhang
    The National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China
    Plant Cell Rep 30:389-98. 2011
    ..1.3.18) catalyses the conversion of GDP-D-mannose to GDP-L-galactose, an important step in the ascorbic acid (AsA) biosynthesis pathway in higher plants...
  97. ncbi Nutrients and their role in host resistance to infection
    Catherine J Field
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada
    J Leukoc Biol 71:16-32. 2002
    ....
  98. ncbi Ascorbic acid depletion enhances expression of the sodium-dependent vitamin C transporters, SVCT1 and SVCT2, and uptake of ascorbic acid in livers of SMP30/GNL knockout mice
    Akiko Amano
    Cellular Genetics, Graduate School of Science and Engineering, Tokyo Metropolitan University, Tokyo 192 0397, Japan
    Arch Biochem Biophys 496:38-44. 2010
    In this study, we examined whether ascorbic acid (AA) and dehydroascorbic acid (DHA), the oxidized form of AA, levels in tissues regulate the AA transporters, sodium-dependent vitamin C transporters (SVCT) 1 and SVCT2 and DHA ..
  99. pmc Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs
    Anja Frömberg
    Institute of Pharmacology, Faculty of Medicine, Philipps University Marburg, Karl von Frisch Strasse 1, 35032 Marburg, Germany
    Cancer Chemother Pharmacol 67:1157-66. 2011
    While the benefits of ascorbic acid (vitamin C, ascorbate) as an essential nutrient are well established, its effects on tumor cells and in tumor treatment are controversial...
  100. ncbi Time course of vitamin C distribution and absorption after oral administration in SMP30/GNL knockout mice
    Mizuki Iwama
    Department of Geriatrics and Vascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Nutrition 27:471-8. 2011
    ..Because vitamin C (VC) has multiple metabolic and antioxidant functions, we investigated the movement of VC throughout the tissues of senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice...
  101. ncbi Proteomic and redox-proteomic evaluation of homogentisic acid and ascorbic acid effects on human articular chondrocytes
    Daniela Braconi
    Dipartimento di Biologia Molecolare, Universita degli Studi di Siena, Via Fiorentina 1, 53100 Siena SI, Italy
    J Cell Biochem 111:922-32. 2010
    ..on articular cells, we carried out a proteomic and redox-proteomic analysis to investigate how HGA and ascorbic acid (ASC) affect the human chondrocytic protein repertoire...

Research Grants65

  1. Pilot and definitive studies to evaluate Insertional Mutagenesis
    LU TAYLOR; Fiscal Year: 2012
    ..multiple analyte profiles (MAPs);N-acetyl-p-Aminophenol(APAP);Nitrosodimethylamine;Anthraquinone;Aflatoxin B1;Ascorbic acid;l-tryptophan;Methlyeugenol;Senna;PolyBrominated diphenyl ether congeners;PBDE-47;Carcinogen and Non-carcinogen;..
  2. Studies to Evaluate the Toxicological Potential of Test Articles
    LU TAYLOR; Fiscal Year: 2010
    ..multiple analyte profiles (MAPs);N-acetyl-p-Aminophenol(APAP);Nitrosodimethylamine;Anthraquinone;Aflatoxin B1;Ascorbic acid;l-tryptophan;Methlyeugenol;Senna;PolyBrominated diphenyl ether congeners;PBDE-47;Carcinogen and Non-carcinogen;..
  3. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-CCC-Lead
    CYNTHIA T MCEVOY; Fiscal Year: 2013
    ..compliance, including urine cotinines levels, smoking questionnaires, pill counts and fasting plasma ascorbic acid levels. Pulmonary function tests will be done at 3 months of age and will measure forced expiratory flows...
  4. A Thioredoxin Mimetic for Radiocontrast Nephropathy
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..R-901 exhibits in vitro potency 450- and 50-fold >than N-acetylcysteine (NAC) and ascorbic acid, respectively, and in vivo potency substantially greater than NAC...
  5. Resuscitation of smoke inhalation and burn injury with a thioredoxin mimetic
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..R-901 exhibits in vitro potency 450- and 50-fold >than N-acetylcysteine (NAC) and ascorbic acid, respectively, and in vivo potency substantialy greater than NAC...
  6. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-DCC
    Cynthia D Morris; Fiscal Year: 2013
    ..compliance, including urine cotinines levels, smoking questionnaires, pill counts and fasting plasma ascorbic acid levels. Pulmonary function tests will be done at 3 months of age and will measure forced expiratory flows...
  7. Vascular effects of dietary salt in humans with salt-resistant BP
    William B Farquhar; Fiscal Year: 2013
    ..condition, and that the dietary salt-induced decline in cutaneous vasodilation will be attenuated by local ascorbic acid infusion providing functional evidence for a role of oxidative stress...
  8. Local Vasoconstriction in Postural Tachycardia Syndrome
    Julian M Stewart; Fiscal Year: 2013
    ..and losartan improve cutaneous NO and will correlate skin responses with systemic responses to intravenous ascorbic acid and oral losartan in later experiments...
  9. ASCORBATE-INDUCED RADIOSENSITIZATION IN PANCREATIC CANCER
    Joseph J Cullen; Fiscal Year: 2013
    ..Intravenous ascorbate (i.e., ascorbic acid, vitamin C), but not oral ascorbate, produces high plasma concentrations, which are in the range that are ..
  10. Quercitrin functions as an antioxidant and protects UV-induced carcinogenesis
    Zhuo Zhang; Fiscal Year: 2012
    ..Our preliminary studies show that this compound displayed a stronger antioxidant activity than that of ascorbic acid over the same concentration range. It blocked TPA-induced neoplastic transformation in JB6 P+ cells...
  11. Nrf1 Molecular Pathway, Vitamin C Deficiency, and Spontaneous Fractures
    Subburaman Mohan; Fiscal Year: 2013
    ..are studying a mutant mouse with deletion of gulunolactone oxidase gene, which is involved in the synthesis of ascorbic acid (AA) that develops spontaneous fractures (sfx) at the very early age of 5-7 wks...
  12. Oxidative stress in regional cerebral blood flow alterations after cardiac arrest
    Mioara D Manole; Fiscal Year: 2012
    ..nitrosative stress will also be quantified: we will measure 3-nitrotyrosine by ELISA and immunofluorescence, ascorbic acid by high liquid field chromatography, and reduced glutathione by fluorescence...
  13. Reduced Inflammatory Suppression of EDD with Habitual Exercise in Older Adults
    Douglas R Seals; Fiscal Year: 2010
    ..The effects of oxidative stress will be assessed by the increase in EDD in response to acute administration of ascorbic acid (vitamin C), a potent antioxidant...
  14. AMINO-CARBONYL REACTIONS IN THE AGING HUMAN LENS
    Vincent M Monnier; Fiscal Year: 2013
    ..by applicant): The focus of our research is to investigate the hypothesis that amino-carbonyl reactions from ascorbic acid play a role in nuclear sclerosis of the aging lens...
  15. Aging, Sleep Apnea, and Vascular Control During Systemic Hypoxia
    Frank A Dinenno; Fiscal Year: 2013
    ..and prostaglandins to this response, and whether acute improvements in endothelium-dependent vasodilation via ascorbic acid infusion augments local hypoxia- induced vasodilation in older healthy and older OSA humans;and (4) we will ..
  16. Targeting beta-catenin in liver pathology: Novel Interactions, Novel Paradigms
    SATDARSHAN SINGH MONGA; Fiscal Year: 2013
    ..humans and primates, rodents synthesize vitamin C in the hepatocytes and regular mouse chow is devoid of ascorbic acid. We hypothesize that increased HCC and oxidative stress in Hep- [unreadable] -Cat KO is due to compromised ..
  17. Optimizing Normal Collagen Replacement in Osteogenesis Imperfecta
    Sarah L Dallas; Fiscal Year: 2013
    ..fusion protein have shown that it behaves similarly to the wild type form, is secreted upon addition of ascorbic acid, co-precipitates with collagen [unreadable]1 chains, and is assembled into banded collagen fibril arrays...
  18. Alpha-Synuclein-Metal Complexes and Oxidative Stress in Parkinson's Disease
    Feimeng Zhou; Fiscal Year: 2012
    ..g., dopamine, glutathione, and ascorbic acid) in the development of oxidative stress and damage...
  19. Weight Loss, Inflammation, and Vascular Endothelial Function in Older Adults
    Douglas R Seals; Fiscal Year: 2010
    ..Intravenous infusion of ascorbic acid, a potent antioxidant, will be used to determine the effects of oxidative stress on EDD...
  20. Vitamin C and cognition in Alzheimer's disease
    Fiona Edith Harrison; Fiscal Year: 2013
    ..In the current application we propose to investigate the role of vitamin C (ascorbic acid;ASC) in the development of neuropathology and cognitive deficits in a mouse model of AD...
  21. ASCORBIC ACID FUNCTION AND METABOLISM
    James M May; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Plasma and cell levels of vitamin C, or ascorbic acid, are decreased about 50% in persons with type II diabetes in sub-optimal glycemic control, despite presumably adequate dietary intakes...
  22. Intermittent Hypoxia: A Model to Study Circulatory Control in Humans
    Urs A Leuenberger; Fiscal Year: 2012
    ..Because the antioxidant ascorbic acid attenuates the sympatho- excitatory effect of intermittent hypoxia, oxidative stress may be responsible...
  23. Vitamin E Requirements in Women,Obese Women and Diabetic Obese Women
    Maret G Traber; Fiscal Year: 2013
    ..Our working hypothesis is that alpha-tocopherol concentrations are maintained by adequate vitamin C (ascorbic acid) concentrations...
  24. Role of Rab proteins in hSVCT1 cell biology in intestinal epithelial cells
    Veedamali S Subramanian; Fiscal Year: 2010
    ..Vitamin C (ascorbic acid) is essential for normal human growth and development...
  25. Reactive Oxygen Species in Intermittent Hypoxia induced Sympathoexcitation
    PETER BERNARD RAVEN; Fiscal Year: 2012
    ..In contrast ascorbic acid (AA) is a water-soluble antioxidant which does not cross the BBB effectively...
  26. Enhancing Dietary Iron and Zinc Bioavailability in Indian Children
    Steven A Abrams; Fiscal Year: 2010
    ..The proposed modification is the inclusion of ~ 20 mg ascorbic acid from fruits and vegetables which will be served with each meal...
  27. Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury (CITRIS-ALI)
    Jonathon D Truwit; Fiscal Year: 2013
    ..This application presents new data showing that parenterally infused high dose ascorbic acid (vitamin C) disrupts multiple proinflammatory/procoagulant cascades that lead to lung injury in septic humans ..
  28. Biological Mechanisms of Vascular Dysfunction with Age and Estrogen Deficiency
    KERRIE MOREAU; Fiscal Year: 2013
    ..Aim 3 will examine the co-administration of BH4 and an anti-oxidant (ascorbic acid;AA) for the restoration of EDD...
  29. Biomarkers of Oxidative Stress in Parkinson's Disease
    M Flint Beal; Fiscal Year: 2010
    ..We will measure plasma levels of 8-OHdG, malondialdehyde, ascorbic acid, uric acid, oxidized and reduced CoQ10, and oxidized and reduced glutathione...
  30. Exercise and Vascular Function in Chronic Kidney Disease
    David G Edwards; Fiscal Year: 2013
    ..hypothesize that oxidative stress will be reduced, and that cutaneous vasodilation will be unaffected by local ascorbic acid infusion following exercise training...
  31. MAILLARD REACTIONS AND OXIDATION IN CATARACTOGENESIS
    Ram H Nagaraj; Fiscal Year: 2012
    ..We will determine how this recently discovered pathway, through which sugars and ascorbic acid modify proteins, contributes to lens aging and cataract formation...
  32. Codrugs of Lipoic Acid and Tocopherol/Tocopheramine for Use as Photoprotective Ag
    Martha A Hass; Fiscal Year: 2011
    ..In addition, TOC and LA interact directly or through endogenous ascorbic acid (ASC) to enhance and prolong their antioxidant effects when delivered to the skin in combination...
  33. Arsenic-induced apoptosis in myeloma
    Lawrence H Boise; Fiscal Year: 2013
    ..in a phase I/II clinical trial to test the safety and efficacy of the combination of arsenic trioxide and ascorbic acid in refractory/relapsed myeloma...
  34. Osteogenic Repair from Human Pluripotent Stem Cells
    Dan S Kaufman; Fiscal Year: 2013
    ..Specifically, osteoinductive including dexamethasone, ascorbic acid, rhFGF-9, rhBMP-2, Wnt3a and rapamycin will be used to stimulate RUNX2-mCit expression...
  35. Protein disulfide isomerases: A new class of antithrombotic targets
    Bruce Furie; Fiscal Year: 2013
    ..A pharmacokinetic study with quercetin and isoquercetin in the presence and absence of ascorbic acid will be performed to determine optimal delivery...
  36. Targeting the choroid plexus for drug translocation into CSF
    Andrew Baird; Fiscal Year: 2010
    ..and CSF that acts as a heretofore unrecognized focal gateway that can deliver naturally occurring agents like ascorbic acid into the brain, and specifically into CSF...
  37. METABOLISM AND NUTRITION OF IRON AND OTHER TRACE METALS
    PAUL SALTMAN; Fiscal Year: 1993
    ..Fe(lll) and Cu(ll) complexes in the presence of ascorbic acid generate hydroxyl free radicals (OH)...
  38. Liver SVCT Systems: Vitamin C Uptake, Roles & Regulation
    Jack C Reidling; Fiscal Year: 2010
    ..b>Ascorbic acid (vitamin C) is a required essential micronutrient and effective antioxidant in humans...
  39. Ocular Disposition of Antimicrobial Agents
    Ashim K Mitra; Fiscal Year: 2010
    ..and glutamate prodrugs), peptide (valine, valine-valine and glycine-valine prodrugs) and ascorbate (ascorbic acid prodrugs) transporters expressed on the cornea and to evaluate these conjugates with respect to their b) ..
  40. Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer
    Joseph J Cullen; Fiscal Year: 2010
    Intravenous ascorbate (ascorbic acid, vitamin C), but not oral ascorbate, produces high plasma concentrations in the range that is cytotoxic to pancreatic cancer cells...
  41. ROLE OF CHLORIDE IN SODIUM-DEPENDENT HYPERTENSION
    Theodore Kurtz; Fiscal Year: 1990
    ....
  42. Improving Graft Patency: A Novel L-Ascorbic Acid ePTFE Modification
    ELAINE KATHRYN GREGORY; Fiscal Year: 2013
    ..The studies described in this proposal will enable us to optimize this graft and investigate the safety and efficacy of this technology in vivo, hastening further preclinical investigation. ..
  43. Bioactivity and Vitamins in Flash-heated Breastmilk
    Caroline Chantry; Fiscal Year: 2005
    ..available aliquots of heated and unheated milk we will measure and compare: a) concentrations of vitamins A, ascorbic acid, thiamine, riboflavin, pyridoxine, folate and B12, known to be relatively heat-sensitive; b) concentration and ..
  44. ENZYMES IN ANIMAL METABOLISM OF OXALATE DERIVATIVES
    Gordon Hamilton; Fiscal Year: 1990
    ..and (5) explore whether oxalyl thiolesters may be intermediates in the metabolism of aromatic amino acids and ascorbic acid (vitamin C) to oxalate...
  45. Mechanisms of PCP genotoxicity & antioxidant modulation
    BENZHAN ZHU; Fiscal Year: 2002
    ..2) Can dietary antioxidants, viz., lipoic acid and ascorbic acid, protect against cytotoxicity and genotoxicity induced by PCP metabolites? Cytotoxic and genotoxic effects of ..
  46. MODULATION OF IRON METABOLISM BY BIOACTIVE MOLECULES
    Kenneth Bridges; Fiscal Year: 2000
    b>Ascorbic acid (vitamin C) is crucial to health and well-being. Scurvy (extreme vitamin deficiency) markedly disturbs iron metabolism and storage, and produces the "classical" findings of perifollicular hemorrhages and "cork-screw" hair...
  47. VITAMIN DELIVERY BY PLACENTA
    Richard Rose; Fiscal Year: 1990
    ..will be directed at understanding the transfer of nicotinic acid, Riboflavin, pantothenic acid, thiamine, ascorbic acid and the product of ascorbic acid oxidation, dehydroascorbic acid...
  48. MECHANISM OF CELL INTOXICATION BY HYBRIN TOXINS
    Ta Min Chang; Fiscal Year: 1993
    ..This information will be very useful for future formulation of more efficient therapeutic hybrid toxins...
  49. LUNG SURFACE ANTIOXIDANT KINETICS MEDIATE OXIDANT INJURY
    Edward Postlethwait; Fiscal Year: 2003
    ..a complex mixture that contains significant concentrations of small molecular weight antioxidants, principally ascorbic acid (AH2), glutathione (GSH), and uric acid (UA), that directly react with O3 and NO2 during their absorption...
  50. NUTRITIONAL PREVENTION OF POLYPS IN THE LARGE BOWEL
    Edward Bresnick; Fiscal Year: 1992
    ..design with the test treatments consisting of (1) 30 mg of beta-carotene daily, (2) the combination of 1 gram ascorbic acid and 400 mg alpha tocopherol daily, (3) both treatments (i.e...
  51. CHEMISTRY AND BIOLOGY OF THE ELASTIN GENE
    JEFFREY DAVIDSON; Fiscal Year: 1999
    ..by blotting and in situ hybridization reveal the complex influence of cytokines, glucocorticoids, and ascorbic acid on elastin expression...
  52. ORAL CONTRACEPTIVES: EFFECT ON VITAMIN C METABOLISM
    K Lei; Fiscal Year: 1980
    ..will identify which of these steroids, or the combined components, are responsible for the reduced tissue ascorbic acid levels established in women and quinea pigs...
  53. NOREPINEPHRINE BIOSYNTHESIS--ROLE OF ASCORBATE
    Kandatege Wimalasena; Fiscal Year: 2000
    ..The role of ascorbic acid (Asc) in the biosynthesis of both catecholamine neurotransmitters and neuropeptide hormones and thus, in ..
  54. GONADOTROPIN - CONTROL OF THE OVARY
    A Midgley; Fiscal Year: 1991
    ..steroid secretion (by solid phase immunoassay), release of protons and electroactive molecules, presumably ascorbic acid (by ion selective potentiometry and amperometric cyclic voltammetry), and morphology (by light and electron ..
  55. Improved polymer gels for radiation dosimetry by MRI
    John Gore; Fiscal Year: 2005
    ..These use a novel initiator system based on copper ion and ascorbic acid which combines with and requires molecular oxygen to start polymerization when the gel is irradiated...
  56. ADVANCED BIOSENSORS FOR THE MEASUREMENT OF CHOLESTEROL
    Paul Hale; Fiscal Year: 1991
    ..negative formal potentials, the sensors can be operated at a potential where common interferents, such as ascorbic acid and uric acid, are not detected...
  57. INTESTINAL METAPLASIA, ASCORBATE, AND H PYLORI
    Julie Parsonnet; Fiscal Year: 1993
    ..Dietary ascorbic acid appears to protect against this malignancy. Recently, H...
  58. Behavioral factors and dietary change in WHTFSMP
    Alok Bhargava; Fiscal Year: 2003
    ..intakes of carbohydrate, saturated, monounsaturated, and polyunsaturated fats, fiber, calcium, a-carotene and ascorbic acid using the data at baseline, six and 12 months from the Control and Intervention groups of the WHTFSMP...
  59. DEHYDROASCORBIC ACID AS THERAPY FOR ISCHEMIC STROKE
    Thomas Boyd; Fiscal Year: 2001
    ..with a rapid increase in free radical content in the brain and a depletion of natural antioxidants such as ascorbic acid. Delivery of ascorbic acid to the site of ischemic injury is limited by its inability to cross the blood-brain ..
  60. MATERNAL ASCORBIC ACID INTAKE AND FETAL DEVELOPMENT
    DEBORAH KIPP; Fiscal Year: 1993
    ..Since ascorbic acid (AA) directly influences collagen production, an inadequate intake of AA by the dam may result in an ..
  61. CHARACTERIZATION OF HUMAN PLACENTAL GLUCOSE TRANSPORT
    ROLF INGERMANN; Fiscal Year: 1990
    ..In contrast, the reversibly reduced form of vitamin C, L-ascorbic acid, does not appear to cross this membrane by the glucose transporter but does not synthesize vitamin C, ..
  62. ELECTROCHEMISTRY-EPR OF BIOLOGICAL ELECTRON TRANSFER
    Ralph Adams; Fiscal Year: 1992
    ..maps of the concentrations of norepinephrine (NE), dopamine (DA), 5-hydroxytryptamine (5-HT) and ascorbic acid (AA) in thalamus, frontal cortex and cingulate cortex will be developed by gridding coronal slices of brain ..
  63. Potential Brain Therapeutics
    Anastasios Raptis; Fiscal Year: 2004
    ..Among these antioxidants, tumeric, neem, guggul, alpha-tocopherol, Beta-carotene, and ascorbic acid have been shown to have a special relevance in maintaining the redox equilibrium in various cell types, ..
  64. Mechanisms of Hypertension in Chronic Kidney Disease
    Crystal Gadegbeku; Fiscal Year: 2009
    ..NO, b) reduced by supplementation with the NO precursor, L-arginine, c) reduced by the anti-oxidant, ascorbic acid, d) reduced by the combination of L-arginine and ascorbic acid, synergistically. 2...
  65. HYALURONIC ACID AND ARTHRITIS
    ENDRE BALAZS; Fiscal Year: 1980
    ..The effect of various agents (lectins, ascorbic acid, and Na-hyaluronate of different molecular sizes) on the quantitative and qualitative aspects of hyaluronic ..