trisaccharides

Summary

Summary: Oligosaccharides containing three monosaccharide units linked by glycosidic bonds.

Top Publications

  1. ncbi Synthesis of Neu5Ac- and Neu5Gc-alpha-(2-->6')-lactosamine 3-aminopropyl glycosides
    A A Sherman
    N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow
    Carbohydr Res 330:445-58. 2001
  2. pmc The Galalpha1,3Galbeta1,4GlcNAc-R (alpha-Gal) epitope: a carbohydrate of unique evolution and clinical relevance
    Bruce A Macher
    Department of Chemistry and Biochemistry, Science 246, 1600 Holloway Ave, San Francisco State University, San Francisco, CA 94132, USA
    Biochim Biophys Acta 1780:75-88. 2008
  3. ncbi Conformational studies of Lewis X and Lewis A trisaccharides using NMR residual dipolar couplings
    Hugo F Azurmendi
    Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Biopolymers 63:89-98. 2002
  4. ncbi Comprehensive profiles of human milk oligosaccharides yield highly sensitive and specific markers for determining secretor status in lactating mothers
    Sarah M Totten
    Department of Chemistry, University of California, Davis, California 95616, United States
    J Proteome Res 11:6124-33. 2012
  5. ncbi Analysis of the role of pglI in pilin glycosylation of Neisseria meningitidis
    Matthew J Warren
    Department of Microbiology and Parasitology, School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
    FEMS Immunol Med Microbiol 41:43-50. 2004
  6. pmc Structure and binding analysis of Polyporus squamosus lectin in complex with the Neu5Ac{alpha}2-6Gal{beta}1-4GlcNAc human-type influenza receptor
    Renuka Kadirvelraj
    Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA
    Glycobiology 21:973-84. 2011
  7. pmc The principal fucosylated oligosaccharides of human milk exhibit prebiotic properties on cultured infant microbiota
    Zhuo Teng Yu
    Department of Pediatric Gastroenterology and Nutrition, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02129, USA
    Glycobiology 23:169-77. 2013
  8. ncbi Increased immunogenicity of tumor-associated antigen, mucin 1, engineered to express alpha-gal epitopes: a novel approach to immunotherapy in pancreatic cancer
    Takashi Deguchi
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    Cancer Res 70:5259-69. 2010
  9. ncbi Synthesis of the milk oligosaccharide 2'-fucosyllactose using recombinant bacterial enzymes
    C Albermann
    Institut für Chemische Mikrobiologie, Bergische Universitat GH, FB9, Gauss Strasse 20, D 42097, Wuppertal, Germany
    Carbohydr Res 334:97-103. 2001
  10. ncbi Antibacterial to antifungal conversion of neamine aminoglycosides through alkyl modification. Strategy for reviving old drugs into agrofungicides
    Cheng Wei T Chang
    Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA
    J Antibiot (Tokyo) 63:667-72. 2010

Detail Information

Publications232 found, 100 shown here

  1. ncbi Synthesis of Neu5Ac- and Neu5Gc-alpha-(2-->6')-lactosamine 3-aminopropyl glycosides
    A A Sherman
    N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow
    Carbohydr Res 330:445-58. 2001
    ..In the trisaccharides, obtained by glycosylation with donor 4, the 5-(N-tert-butoxycarbonylacetamido) moiety in the neuraminic acid ..
  2. pmc The Galalpha1,3Galbeta1,4GlcNAc-R (alpha-Gal) epitope: a carbohydrate of unique evolution and clinical relevance
    Bruce A Macher
    Department of Chemistry and Biochemistry, Science 246, 1600 Holloway Ave, San Francisco State University, San Francisco, CA 94132, USA
    Biochim Biophys Acta 1780:75-88. 2008
    ..This review covers these topics and new avenues of clinical importance related to this unique antigen/antibody system (alpha-gal epitope/anti-Gal) in improving the efficacy of viral vaccines and in immunotherapy against cancer...
  3. ncbi Conformational studies of Lewis X and Lewis A trisaccharides using NMR residual dipolar couplings
    Hugo F Azurmendi
    Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Biopolymers 63:89-98. 2002
    ..Monte Carlo simulations were used to generate models for the trisaccharides, and orientations of each model were sought that could reproduce the experimental residual dipolar coupling ..
  4. ncbi Comprehensive profiles of human milk oligosaccharides yield highly sensitive and specific markers for determining secretor status in lactating mothers
    Sarah M Totten
    Department of Chemistry, University of California, Davis, California 95616, United States
    J Proteome Res 11:6124-33. 2012
    ..Also in this study, four specific fucosylated structures (2'FL, LNFP I, LDFT, and LNDFH I) were determined to be specific and sensitive glycan markers for rapidly determining secretor status without the need for serological testing...
  5. ncbi Analysis of the role of pglI in pilin glycosylation of Neisseria meningitidis
    Matthew J Warren
    Department of Microbiology and Parasitology, School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
    FEMS Immunol Med Microbiol 41:43-50. 2004
    ..These data, in conjunction with homology with well-characterised acyltransferases suggests a specific role for pglI in the biosynthesis of the basal 2,4-diacetamido-2,4,6-trideoxyhexose residue of the pilin-linked glycan...
  6. pmc Structure and binding analysis of Polyporus squamosus lectin in complex with the Neu5Ac{alpha}2-6Gal{beta}1-4GlcNAc human-type influenza receptor
    Renuka Kadirvelraj
    Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA
    Glycobiology 21:973-84. 2011
    ....
  7. pmc The principal fucosylated oligosaccharides of human milk exhibit prebiotic properties on cultured infant microbiota
    Zhuo Teng Yu
    Department of Pediatric Gastroenterology and Nutrition, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02129, USA
    Glycobiology 23:169-77. 2013
    ..Thus, these simple glycans could mediate beneficial effects of human milk on infant health...
  8. ncbi Increased immunogenicity of tumor-associated antigen, mucin 1, engineered to express alpha-gal epitopes: a novel approach to immunotherapy in pancreatic cancer
    Takashi Deguchi
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    Cancer Res 70:5259-69. 2010
    ..The results suggested that vaccination using cells engineered to express alpha-gal epitopes is a novel strategy for treatment of pancreatic cancer...
  9. ncbi Synthesis of the milk oligosaccharide 2'-fucosyllactose using recombinant bacterial enzymes
    C Albermann
    Institut für Chemische Mikrobiologie, Bergische Universitat GH, FB9, Gauss Strasse 20, D 42097, Wuppertal, Germany
    Carbohydr Res 334:97-103. 2001
    ..The isolation of 2'-fucosyllactose was accomplished by anion-exchange chromatography and gel filtration to give 65% yield...
  10. ncbi Antibacterial to antifungal conversion of neamine aminoglycosides through alkyl modification. Strategy for reviving old drugs into agrofungicides
    Cheng Wei T Chang
    Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA
    J Antibiot (Tokyo) 63:667-72. 2010
    ..In addition, this strategy is an example of reviving a clinically obsolete drug by simple chemical modification to yield a new application...
  11. ncbi Enzymatic synthesis and identification of two trisaccharides produced from lactulose by transgalactosylation
    Cristina Martinez-Villaluenga
    Instituto de Fermentaciones Industriales, Consejo Superior de Investigaciones Cientificas, Juan de la Cierva, 3, Madrid 28006, Spain
    J Agric Food Chem 56:557-63. 2008
    ..During hydrolysis of lactulose, the formation of two novel trisaccharides was followed by high-performance anion-exchange chromatography with pulsed amperometric detection (HPAEC-PAD)...
  12. ncbi Identification of Bacillus selenitireducens MLS10 maltose phosphorylase possessing synthetic ability for branched α-D-glucosyl trisaccharides
    Takanori Nihira
    Faculty of Agriculture, Niigata University, Niigata 950 2181, Japan
    Carbohydr Res 360:25-30. 2012
    ..65 from Bacillus selenitireducens MLS10, which possesses synthetic ability for α-D-glucosyl disaccharides and trisaccharides through the reverse phosphorolysis with β-D-glucose 1-phosphate as the donor...
  13. ncbi Marine bacterial sulfated fucoglucuronomannan (SFGM) lyase digests brown algal SFGM into trisaccharides
    Takeshi Sakai
    Takara Shuzo Co, Ltd, Biomedical Group, Zaifu cho 82 4, Hirosaki Shi, Aomori ken, 036 8216, Japan
    Mar Biotechnol (NY) 5:70-8. 2003
    Three kinds of trisaccharides were prepared by digesting fucoidan from the brown alga Kjellmaniella crassifolia, with the extracellular enzymes of the marine bacterium Fucobacter marina...
  14. ncbi Production of Lewis x tetrasaccharides by metabolically engineered Escherichia coli
    Claire Dumon
    Centre de Recherches sur les Macromolecules Vegetales, ICMG, FR CNRS UJF 2607, B P 53, 38041 Grenoble Cedex 9, France
    Chembiochem 7:359-65. 2006
    ..meningitidis lgtA gene for beta-3 N-acetylglucosaminyltransferase...
  15. pmc Whole cell biosynthesis of a functional oligosaccharide, 2'-fucosyllactose, using engineered Escherichia coli
    Won Heong Lee
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Microb Cell Fact 11:48. 2012
    ....
  16. ncbi Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor
    M Mayer
    Institute of Organic Chemistry, University of Hamburg, Martin Luther King Pl 6, 20146 Hamburg, Germany
    J Am Chem Soc 123:6108-17. 2001
    ..Analysis of STD NMR experiments performed under competitive conditions proved that the two saccharides studied bind at the same receptor site, thereby ruling out unspecific binding...
  17. ncbi Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor
    F A Quiocho
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Structure 5:997-1015. 1997
    ....
  18. pmc Immunogenicity of influenza virus vaccine is increased by anti-gal-mediated targeting to antigen-presenting cells
    Ussama M Abdel-Motal
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, LRB, Worcester, MA 01605, USA
    J Virol 81:9131-41. 2007
    ..We suggest that a similar method for increasing immunogenicity may be applicable to avian influenza vaccines...
  19. ncbi Identification of a novel gene involved in pilin glycosylation in Neisseria meningitidis
    M P Jennings
    Department of Microbiology, The University of Queensland, Brisbane, Australia
    Mol Microbiol 29:975-84. 1998
    ....
  20. ncbi Comparison of the MTT1- and MAL31-like maltose transporter genes in lager yeast strains
    Judith Dietvorst
    Section Molecular and Developmental Genetics, Institute of Biology Leiden, Leiden University, Leiden, The Netherlands
    FEMS Microbiol Lett 310:152-7. 2010
    ..As the promoter regions of the MTT1 and MAL31 genes are identical, small differences in the protein sequence may be responsible for the different properties of these genes...
  21. ncbi Site-specific discrimination by cyanovirin-N for alpha-linked trisaccharides comprising the three arms of Man(8) and Man(9)
    Carole A Bewley
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0820, USA
    J Mol Biol 322:881-9. 2002
    ..CVN affinity and selectivity, we have characterized by NMR and ITC the binding of CVN to three synthetic trisaccharides representing the full-length D1, D2 and D3 arms of mammalian oligomannosides...
  22. ncbi Accelerated healing of skin burns by anti-Gal/alpha-gal liposomes interaction
    Uri Galili
    Department of Surgery, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Burns 36:239-51. 2010
    ..Since anti-Gal is abundant in all humans, it is suggested that treatment with alpha-gal liposomes will be effective also in patients with burns and other skin wounds...
  23. ncbi Anti-Gal-mediated targeting of human B lymphoma cells to antigen-presenting cells: a potential method for immunotherapy using autologous tumor cells
    Olivier Manches
    Research and Development Laboratory, EFS Rhone Alpes, Grenoble, EA 2021, France
    Haematologica 90:625-34. 2005
    ..Anti-Gal constitutes 1% of IgG in human serum and interacts specifically with the alpha-gal epitope (Galalpha1-3Galphalbeta1-4GlcNAc-R)...
  24. ncbi Anomeric information obtained from a series of synthetic trisaccharides using energy resolved mass spectra
    Shusaku Daikoku
    Mitsubishi Kagaku Institute of Life Sciences, Machida shi, Tokyo, Japan
    J Mass Spectrom 42:714-23. 2007
    ..The trisaccharides used in the analysis consisted of L-fucose, D-galactose and D-glucose, in which individual glycosidic linkages ..
  25. pmc Maltotriose utilization by industrial Saccharomyces strains: characterization of a new member of the alpha-glucoside transporter family
    Madalena Salema-Oom
    Instituto Superior de Ciências da Saúde Sul, 2829 511 Caparica, Portugal
    Appl Environ Microbiol 71:5044-9. 2005
    ..Interestingly, Mty1p displays higher affinity for maltotriose than for maltose, a new feature among all the alpha-glucoside transporters described so far...
  26. ncbi Analysis of a series of isomeric oligosaccharides by energy-resolved mass spectrometry: a challenge on homobranched trisaccharides
    Shusaku Daikoku
    Mitsubishi Kagaku Institute of Life Sciences MITILS, Minamiooya 11, Machida shi, Tokyo 194 8511 Japan
    Rapid Commun Mass Spectrom 23:3713-9. 2009
    ..In our endeavor to address the issue, we analyzed a series of homo-substituted trisaccharides consisting only of glucose by collision-induced dissociation (CID), especially energy-resolved mass ..
  27. ncbi Maltotriose utilization in lager yeast strains: MTT1 encodes a maltotriose transporter
    J Dietvorst
    Institute of Biology Leiden, Leiden University, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands
    Yeast 22:775-88. 2005
    ..Introduction of MTT1 or MTT1alt into lager strain A15 raised maltotriose uptake by about 17% or 105%, respectively...
  28. pmc Unraveling the difference between invertases and fructan exohydrolases: a single amino acid (Asp-239) substitution transforms Arabidopsis cell wall invertase1 into a fructan 1-exohydrolase
    Katrien Le Roy
    Laboratory of Molecular Plant Physiology, Institute of Botany and Microbiology, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Plant Physiol 145:616-25. 2007
    ..The presence or absence of such an Asp-239 homolog is proposed as a reliable determinant to discriminate between real invertases and defective invertases/FEHs...
  29. ncbi Selective binding of the scavenger receptor C-type lectin to Lewisx trisaccharide and related glycan ligands
    Peter J Coombs
    Glycobiology Institute, Department of Biochemistry, University of Oxford, UK
    J Biol Chem 280:22993-9. 2005
    ..These studies suggest that SRCL might be involved in selective clearance of specific desialylated glycoproteins from circulation and/or interaction of cells bearing Lewis(x)-type structures with the vascular endothelium...
  30. pmc Structural basis for the recognition of blood group trisaccharides by norovirus
    Sheng Cao
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China
    J Virol 81:5949-57. 2007
    ..a recombinant P protein of a GII-4 strain norovirus, VA387, was cocrystallized with synthetic type A or B trisaccharides. Based on complex crystal structures observed at a 2...
  31. ncbi Characterization of oligosaccharides from the chondroitin/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced trisaccharides and hexasaccharides
    Thomas N Huckerby
    Department of Biological Sciences, Lancaster University, UK
    FEBS J 272:6276-86. 2005
    ..studied include a disaccharide and hexasaccharides from chondroitin ABC lyase digestion as well as trisaccharides already present in some commercial preparations...
  32. ncbi Separation of sodiated isobaric disaccharides and trisaccharides using electrospray ionization-atmospheric pressure ion mobility-time of flight mass spectrometry
    Brian H Clowers
    Department of Chemistry, Washington State University, Pullman, Washington 99164, USA
    J Am Soc Mass Spectrom 16:660-9. 2005
    A series of isobaric disaccharide-alditols, four derived from O-linked glycoproteins, and select trisaccharides were rapidly resolved using tandem high resolution atmospheric pressure ion-mobility time-of-flight mass spectrometry...
  33. ncbi Alterations in serum anti-alpha-galactosyl antibodies in patients with Crohn's disease and ulcerative colitis
    Mariadomenica D'Alessandro
    Dipartimento di Chirurgia Generale Paride Stefanini, Universita degli Studi La Sapienza, Rome, Italy
    Clin Immunol 103:63-8. 2002
    ....
  34. pmc Molecular analysis of maltotriose active transport and fermentation by Saccharomyces cerevisiae reveals a determinant role for the AGT1 permease
    Sergio L Alves
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, SC 88040 900, Brazil
    Appl Environ Microbiol 74:1494-501. 2008
    ..cerevisiae yeasts, highlighting the importance of this permease for breeding and/or selection programs aimed at improving sluggish maltotriose fermentations...
  35. ncbi Gas chromatographic-mass spectrometric method for the qualitative and quantitative determination of disaccharides and trisaccharides in honey
    M L Sanz
    Instituto de Quimica Organica General, Juan de la Cierva, 3, E 28006 Madrid, Spain
    J Chromatogr A 1059:143-8. 2004
    An improved method has been developed to identify and quantify honey disaccharides and trisaccharides by gas chromatography and mass spectrometry...
  36. pmc Structural characterization of a lectin from the mushroom Marasmius oreades in complex with the blood group B trisaccharide and calcium
    Elin M Grahn
    Department of Chemistry, University of Oslo, Norway
    J Mol Biol 390:457-66. 2009
    ..Also, in this work, Ca(2+) was included in the crystals, and binding of Ca(2+) to the MOA homodimer altered the conformation of the C-terminal domain by opening up the cleft containing a putative catalytic site...
  37. ncbi A maltooligosaccharide-forming amylase gene from Brachybacterium sp. strain LB25: cloning and expression in Escherichia coli
    Noriyuki Doukyu
    Bio Nano Electronic Research Center, Toyo University, Saitama, Japan
    Biosci Biotechnol Biochem 72:2444-7. 2008
    ..The amylase gene was expressed in Escherichia coli, but the specific activity of the recombinant amylase was lower than that of the amylase purified from strain LB25...
  38. ncbi Open-to-closed transition in apo maltose-binding protein observed by paramagnetic NMR
    Chun Tang
    Laboratory of Chemical Physics, Building 5, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0520, USA
    Nature 449:1078-82. 2007
    ..Using ensemble simulated annealing refinement against the PRE data we are able to determine a <r(-6)> ensemble average structure of the minor apo species and show that it is distinct from the sugar-bound state...
  39. ncbi Effective treatment of preexisting melanoma with whole cell vaccines expressing alpha(1,3)-galactosyl epitopes
    Gabriela R Rossi
    NewLink Genetics Corp, ISU Research Park, Ames, Iowa and Iowa Cancer Research Foundation, Urbandale, Iowa 50010 8646, USA
    Cancer Res 65:10555-61. 2005
    ..Vaccination with B16alphagal induced strong long-lasting cell-mediated antitumor immunity extended to B16Null. These data formed the basis for the testing of this therapeutic strategy in human clinical trials currently under way...
  40. ncbi Synthesis of cross-reactive carbohydrate determinants fragments as tools for in vitro allergy diagnosis
    Mayeul Collot
    Ecole Normale Superieure, Departement de Chimie, Universite Paris 6, UMR CNRS 7203, 24 rue Lhomond, 75005 Paris, France
    Bioorg Med Chem 19:1306-20. 2011
    ..The results showed the potential utility of these xylosylated and fucosylated oligosaccharide fragments in determining CCD antibody epitopes...
  41. ncbi Enzymatic synthesis of blood group A and B trisaccharide analogues
    N O Seto
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ont
    Carbohydr Res 324:161-9. 2000
    ..4% that of UDP-GalNAc and the rate of transfer with UDP-Glc by the B enzyme was 0.01% that of UDP-Gal, these cloned enzymes could be used for the enzymatic synthesis of blood group A and B trisaccharide analogs 4 and 5...
  42. ncbi Reduction of anti-Galalpha1,3Gal antibodies by infusion of types 2 and 6 gal trisaccharides conjugated to poly-L-lysine
    K Kuwaki
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Xenotransplantation 11:210-5. 2004
    ..There remain small fractions of antibody that are unadsorbed, particularly of IgG, probably due to their low affinity and distribution in both the intra- and extra-vascular compartments...
  43. ncbi Unusual conformational behavior of trisaccharides containing N-acetylglucosamine
    Liang Liao
    Department of Chemistry, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Carbohydr Res 340:2826-32. 2005
    Protected trisaccharides containing N-acetylglucosamine can adopt unexpected conformations through the formation of hydrogen bonds involving the amide group...
  44. ncbi Preparation of partially benzylated mono-, di-, and trisaccharides by selective cleavage of the beta-fructofuranosidic linkage in fully benzylated sucrose and sucrose-related oligosaccharides under acidic conditions
    Takashi Yamanoi
    The Noguchi Institute, Tokyo, Japan
    Carbohydr Res 343:1366-72. 2008
    Several partially benzylated mono-, di-, and trisaccharides having an anomeric hydroxyl group were successfully prepared by selective cleavage of the beta-fructofuranosidic linkage in fully benzylated sucrose and sucrose-related ..
  45. ncbi Chemo-enzymatic synthesis of conformationally constrained oligosaccharides
    M Carmen Galan
    Complex Carbohydrate Research Center, University of Georgia, 220 Riverbend Road, Athens, GA 30602, USA
    Org Biomol Chem 1:3891-9. 2003
    ..ST6GalI) or recombinant human fucosyltransferase V (FucT-V) to give conformationally constrained trisaccharides 5 and 6, respectively...
  46. ncbi MM3 potential energy surfaces of trisaccharides. II. Carrageenan models containing 3,6-anhydro-D-galactose
    Carlos A Stortz
    Departamento de Quimica Organica CIHIDECAR, Fac Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina
    Biopolymers 70:227-39. 2003
    The adiabatic potential energy surfaces (PES) of six trisaccharides-namely 3,6-An-alpha-D-Galp-(1-->3)-beta-D-Galp-(1-->4)-3,6-An-alpha-D-Galp, beta-D-Galp-(1-->4)-3,6-An-alpha-D-Galp-(1-->3)-beta-D-Galp, and their derivatives ..
  47. ncbi Fast and efficient synthesis of a novel homologous series of L-fucosylated trisaccharides using the Helix pomatia alpha-(1-->2)-L-galactosyltransferase
    Angela Michelle Scheppokat
    Institut fur Organische Chemie, Universitat Hamburg, Martin Luther King Platz 6, D 20146 Hamburg, Germany
    Carbohydr Res 338:2083-90. 2003
    ..The homologous series of trisaccharides thus produced were fully characterised by NMR analysis of their peracetates.
  48. ncbi Highly efficient synthesis of alternate alpha- and beta-(1-->3)-linked glucose hepta- and octasaccharides
    Ying Zeng
    Research Center for Eco Environmental Sciences, Academia Sinica, Chinese Academy of Sciences, P O Box 2871, Beijing 100085, PR China
    Carbohydr Res 338:2047-56. 2003
    ....
  49. pmc One-pot synthesis of oligosaccharides by combining reductive openings of benzylidene acetals and glycosylations
    Yusuf Vohra
    Complex Carbohydrate Research Center, The University of Georgia, 315 Riverbend Road, Athens, Georgia 30602, USA
    Org Lett 10:3247-50. 2008
    ..glycosylations of trichloroacetimidates with reductive opening of benzylidene acetals with triflic acid and triethylsilane as one-pot procedures provides access to a wide range of disaccharides and 2,4- and 3,4-branched trisaccharides.
  50. ncbi First synthesis of the beta-D-rhamnosylated trisaccharide repeating unit of the O-antigen from Xanthomonas campestris pv. campestris 8004
    Emiliano Bedini
    Dipartimento di Chimica Organica e Biochimica, Universita di Napoli Federico II, Complesso Universitario Monte Santangelo, Via Cintia 4, 80126 Napoli, Italy
    J Org Chem 70:8064-70. 2005
    ....
  51. ncbi Carbohydrate and protein-based inhibitors of porcine pancreatic alpha-amylase: structure analysis and comparison of their binding characteristics
    M Machius
    Max Planck Institut fur Biochemie, Martinsried, Germany
    J Mol Biol 260:409-21. 1996
    ....
  52. ncbi Synthesis of GDP-5-thiosugars and their use as glycosyl donor substrates for glycosyltransferases
    Osamu Tsuruta
    Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama 226 8501, Japan
    J Org Chem 68:6400-6. 2003
    ..These findings for GDP-5-thiosugars together with previous demonstrations of enzymatic transfer from UDP-5-thiosugars will allow the production of panels of oligosaccharide analogues with hydrolase-resistant properties...
  53. ncbi Sequencing and characterization of oligosaccharides using infrared multiphoton dissociation and boronic acid derivatization in a quadrupole ion trap
    Michael Pikulski
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712 0165, USA
    J Am Soc Mass Spectrom 18:2094-106. 2007
    ..We demonstrate this approach for two series of oligosaccharides, the lacto-N-fucopentaoses (LNFPs) and the lacto-N-difucohexaoses (LNDFHs)...
  54. ncbi Characterization of the recognition of blood group B trisaccharide derivatives by the lectin from Marasmius oreades using frontal affinity chromatography-mass spectrometry
    Brian P Rempel
    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2
    Glycoconj J 19:175-80. 2002
    ..Since the solution NMR structure and crystal structure of the B-trisaccharide are known [3], we propose the specific surface of the trisaccharide that is recognized by the lectin...
  55. ncbi Synthesis of S-linked thiooligosaccharide analogues of Nod factors: synthesis of new protected thiodisaccharide and thiotrisaccharide intermediates
    Latino Loureiro Morais
    Laboratoire de Chimie des Hétérocycles et des Glucides, Ecole Nationale Supérieure de Chimie de Clermont Ferrand, BP 187, F 63174, Aubiere, France
    Carbohydr Res 338:1369-79. 2003
    ..The work described here shows that thiodisaccharide glycosyl donors behave quite differently from the analogous O-disaccharide used previously to synthesize nodulation factors...
  56. ncbi Lactones of disialyl lactose: characterisation by NMR and mass spectra
    Geoffrey Ge Pan
    Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Carbohydr Res 341:730-7. 2006
    ....
  57. ncbi Synthesis of oligosaccharides as potential inhibitors of mycobacterial arabinosyltransferases. Di- and trisaccharides containing C-5 modified arabinofuranosyl residues
    Oana M Cociorva
    Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH 43210, USA
    Carbohydr Res 339:853-65. 2004
    ..Deprotection of the glycosylation products afforded the azido, fluoro, or methoxy analogs directly. The amino derivatives were obtained in one additional step by reduction of the azido compounds...
  58. ncbi Synthesis and conformational analysis of novel N(OCH3)-linked disaccharide analogues
    Francesco Peri
    Department of Biotechnology and Biosciences, University of Milano Bicocca, 20126 Milan, Italy
    Chemistry 10:1433-44. 2004
    ..It appears that N(OMe)-linked disaccharide analogues exhibit a slightly different conformational behavior to their parent natural disaccharides...
  59. ncbi Chemoenzymatic synthesis of 6omega -modified maltooligosaccharides from cyclodextrin derivatives
    Carole Fraschini
    Centre de Recherches sur les Macromolecules Vegetales CERMAV CNRS, FR CNRS 2607, BP 53, 38041 Grenoble Cedex 9, France
    Carbohydr Res 340:1893-9. 2005
    ..These results provided new information about the specificity of the catalytic sites of CGTase and amyloglucosidase. They also offered new ways for the synthesis of regioselectively modified maltooligosaccharides...
  60. ncbi Affinity and kinetics of sialyl Lewis-X and core-2 based oligosaccharides binding to L- and P-selectin
    Mark E Beauharnois
    Department of Chemical and Biological Engineering, State University of New York, Buffalo, New York 14260, USA
    Biochemistry 44:9507-19. 2005
    ..Similar binding kinetics are expected for sLe(X)-selectin interactions. Taken together, our study provides new insight into the kinetics and mechanisms of carbohydrate interaction with selectins...
  61. ncbi Sensitization with xenogeneic tissues alters the heavy chain repertoire of human anti-Galalpha1-3Gal antibodies
    Paul B Yu
    Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA
    Transplantation 80:102-9. 2005
    ..We asked how sensitization with the carbohydrate Galalpha1-3Gal modifies antibody heavy chain use...
  62. ncbi A tetrahydro beta-carboline trisaccharide from Palicourea coriacea (Cham.) K. Schum
    Claudia A do Nascimento
    Instituto de Quimica, Universidade Federal de Goias, Campus Samambaia, 74001 970 Goiânia GO, Brazil
    Carbohydr Res 343:1104-7. 2008
    ..A new tetrahydro beta-carboline alkaloid that has an oligosaccharide unit was isolated from the root extracts of the Palicourea coriacea. The structure was elucidated using spectral methods, including 2D NMR: COSY, HMQC, HMBC and NOESY...
  63. ncbi Synthesis of an alpha-linked dimer of the trisaccharide repeating unit of the exopolysaccharide produced by Pediococcus damnosus 2.6
    Aixiao Li
    Research Center for Eco Environmental Sciences, Academia Sinica, PO Box 2871, Beijing 100085, China
    Carbohydr Res 339:2499-506. 2004
    ..Condensation of 12 with 24 furnished only the alpha-linked hexasaccharide 25, and its deprotection gave the free hexaoside 27...
  64. ncbi NMR study on the hydroxy protons of the Lewis X and Lewis Y oligosaccharides
    Somer Bekiroglu
    Department of Chemistry, Swedish University of Agricultural Sciences, PO Box 7015, SE 750 07 Uppsala, Sweden
    Carbohydr Res 339:2465-8. 2004
    ..The inter-residue NOEs involving the exchangeable NH and OH protons confirmed the stacking interaction between the Fucp linked to the GlcpNAc and the Galp residues in Lewis X and Lewis Y...
  65. ncbi Synergistic interactions between the genetically modified bacterial polysaccharide P2 and carob or konjac mannan
    Michael Ridout
    Institute of Food Research, Food Material Science, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Carbohydr Res 339:2233-9. 2004
    ..The former site of acetylation inhibits helix formation for P2. It is suggested that this site of acetylation also inhibits formation of the mixed helix, explaining the enhanced gelation of mixtures on deacetylation...
  66. ncbi Enzymatic synthesis of complex glycosaminotrioses and study of their molecular recognition by hevein domains
    Nuria Aboitiz
    Centro de Investigaciones Biologicas, CSIC, Ramiro de Maeztu 9, Madrid, Spain
    Org Biomol Chem 2:1987-94. 2004
    ..By using NMR and molecular modeling as major tools we have demonstrated that trisaccharides containing GalNAc and ManNAc residues are also recognized by hevein domains...
  67. ncbi An improvement in the bending ability of a hinged trisaccharide with the assistance of a sugar-sugar interaction
    Hideya Yuasa
    Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 B3 Nagatsutacho, Midoriku, Yokohama 226 8501, Japan
    Chemistry 11:6478-90. 2005
    Hinged di- and trisaccharides incorporating 2,4-diamino-beta-D-xylopyranoside as a hinge unit (Hin) were synthesized...
  68. ncbi The fucose-binding lectin from Ralstonia solanacearum. A new type of beta-propeller architecture formed by oligomerization and interacting with fucoside, fucosyllactose, and plant xyloglucan
    Nikola Kostlánová
    National Centre for Biomolecular Research and Department of Biochemistry, Masaryk University, Brno 611 37, Czech Republic
    J Biol Chem 280:27839-49. 2005
    ..Crystals were also obtained for a mutated lectin complexed with a fragment of xyloglucan, a fucosylated polysaccharide from the primary cell wall of plants, which may be the biological target of the lectin...
  69. ncbi Oligosaccharides implicated in recognition are predicted to have relatively ordered structures
    Andrew Almond
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    Biochemistry 43:5853-63. 2004
    ..Such a conclusion is crucial for understanding how these molecules interact with proteins and impart their recognition properties...
  70. ncbi Chemoenzymatic synthesis of the sialyl-alpha-(2-->3')-lactosamine trisaccharide with a 3-aminopropyl group as a spacer at the reducing end
    Indrani Choudhury Mukherjee
    Laboratory of Advanced Bioelectronics, National Institute of Advanced Industrial Science and Technology AIST, Central 5, 1 1 1 Higashi, Tsukuba, 305 8565, Ibaraki, Japan
    Carbohydr Res 338:1265-70. 2003
    ....
  71. ncbi Structural analysis of a chimeric bacterial alpha-amylase. High-resolution analysis of native and ligand complexes
    A M Brzozowski
    Department of Chemistry, Structural Biology Laboratory, University of York, Heslington, UK
    Biochemistry 39:9099-107. 2000
    ....
  72. ncbi Mild one-pot preparation of glycosyl bromides
    Mo Hunsen
    Department of Chemistry, Kenyon College, Gambier, OH 43022, USA
    Carbohydr Res 340:2670-4. 2005
    ..Mild one-pot protocols for the preparation of glycosyl bromides and alkyl bromides via in situ generation of HBr is reported here...
  73. ncbi Solid-phase synthesis of complex oligosaccharides using a novel capping reagent
    Xiangyang Wu
    Fachbereich Chemie, Universitat Konstanz, Fach M 725, D 78457 Konstanz, Germany
    J Org Chem 69:1853-7. 2004
    ..In this way, the target molecules could be efficiently obtained with little byproduct formation, and hence final purification was convenient...
  74. ncbi Thermodynamic evidence for Ca2+-mediated self-aggregation of Lewis X gold glyconanoparticles. A model for cell adhesion via carbohydrate-carbohydrate interaction
    Jesus M de la Fuente
    Grupo de Carbohidratos, Laboratory of Glyconanotechnology, IIQ CSIC, Americo Vespucio 49, 41092 Seville, Spain
    J Am Chem Soc 127:6192-7. 2005
    ..The relevance of this result to cell-cell adhesion process mediated by carbohydrate-carbohydrate interactions is discussed...
  75. ncbi Synthesis and structural analysis of five novel oligosaccharides prepared by glucosyltransfer from beta-D-glucose 1-phosphate to isokestose and nystose using Thermoanaerobacter brockii kojibiose phosphorylase
    Hideki Okada
    Department of Food Production and Utility Development, Graduate School of Dairy Science Research, Rakuno Gakuen University, Ebetsu 069 8501, Japan
    Carbohydr Res 338:879-85. 2003
    ..1H, 13C NMR signals of each saccharide were assigned using 2D-NMR techniques, including COSY, HSQC, HSQC-TOCSY, HMBC, CH(2)-selected E-HSQC, and CH(2)-selected E-HSQC-TOCSY...
  76. ncbi Synthesis and inhibitory activity of a di- and a trisaccharide corresponding to an erythrocyte glycolipid responsible for the nor polyagglutination
    Ulrika Westerlind
    Department of Chemistry, Swedish University of Agricultural Sciences, PO Box 7015, S 750 07, Uppsala, Sweden
    Carbohydr Res 337:1517-22. 2002
    ..Both the synthesized oligosaccharides inhibited specifically human anti-NOR antibodies, the trisaccharide being 300 times more active than the disaccharide...
  77. ncbi Application of the anomeric samarium route for the convergent synthesis of the C-linked trisaccharide alpha-D-Man-(1-->3)-[alpha-D-Man-(1-->6)]-D-Man and the disaccharides alpha-D-Man-(1-->3)-D-Man and alpha-D-Man-(1-->6)-D-Man
    Lise Munch Mikkelsen
    Department of Chemistry, University of Aarhus, Langelandsgade 140, 8000 Aarhus C, Denmark
    J Org Chem 67:6297-308. 2002
    ....
  78. ncbi Large-scale chemical and chemo-enzymatic synthesis of a spacer-containing Pk-trisaccharide
    Vivekanand P Kamath
    Department of Research and Process Development, SYNSORB Biotech Inc, 201, 1204 Kensington Road Calgary, Canada AB T2E 6J7
    Carbohydr Res 339:1141-6. 2004
    ....
  79. ncbi A conformational dynamics study of alpha-l-Rhap-(1-->2)[alpha-l-Rhap-(1-->3)]-alpha-l-Rhap-OMe in solution by NMR experiments and molecular simulations
    Robert Eklund
    Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S 10691 Stockholm, Sweden
    J Phys Chem B 109:19936-45. 2005
    ....
  80. ncbi Differential expression of an alpha-galactosyl-containing trisaccharide on high- and low-malignant murine sarcoma cells: identification and regulation
    James Varani
    Departments of Pathology, The University of Michigan Medical School, Ann Arbor 48109, USA
    Clin Exp Metastasis 19:1-8. 2002
    ..These studies also identify a mechanism to account for surface carbohydrate differences between the high- and low-malignant cells...
  81. ncbi 23Na NMR study of the interaction between hyaluronan and the bications Ca(++), Mg(++) and Cu(++)
    M Adrian-Scotto
    Laboratoire de Biophysique, Universite de Nice Sophia Antipolis, Parc Valrose 06108 Nice Cedex 2, France
    J Biomol Struct Dyn 19:715-24. 2002
    ....
  82. ncbi The mannose/N-acetylgalactosamine-4-SO4 receptor displays greater specificity for multivalent than monovalent ligands
    D S Roseman
    Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    J Biol Chem 276:17052-7. 2001
    ..8 and 16.2 microm, respectively. Multivalent conjugates of the same GalNAc-4-SO4- and GalNAc-3-SO4-bearing trisaccharides (6.7 mol of trisaccharide/mol of bovine serum albumin) have K(i) values of 0.013 and 0...
  83. ncbi A novel disaccharide substrate having 1,2-oxazoline moiety for detection of transglycosylating activity of endoglycosidases
    M Fujita
    Graduate School of Engineering, Tohoku University, Sendai, Miyagi, Japan
    Biochim Biophys Acta 1528:9-14. 2001
    ..Based on these results, a new mechanism including an oxazolinium ion intermediate has been proposed for the endoglycosidase-catalyzed hydrolysis or transglycosylation...
  84. ncbi Tolerization of Gal alpha 1,3Gal-reactive B cells in pre-sensitized alpha 1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism
    H Ohdan
    Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
    Xenotransplantation 8:227-38. 2001
    ..The absence of B cells with receptors recognizing Gal in mixed chimeras suggests a role for clonal deletion/receptor editing in the maintenance of B cell tolerance...
  85. ncbi Oligosaccharide synthesis with glycosyl phosphate and dithiophosphate triesters as glycosylating agents
    O J Plante
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 123:9545-54. 2001
    ..The procedures outlined here provide the basis for the assembly of complex oligosaccharides in solution and by automated solid-phase synthesis with glycosyl phosphate building blocks exclusively or in concert with other donors...
  86. ncbi Natural and recombinant A and B gene encoded glycosyltransferases
    M M Palcic
    Department of Chemistry, University of Alberta, Edmonton, Alberta Canada T6G 2G2
    Transfus Med 11:315-23. 2001
    ..These studies have shown that donor specificity is attributed to the last two amino acids. Mutants have also been produced with greatly enhanced turnover rates as well as hybrid A/B enzymes that catalyse both reactions efficiently...
  87. ncbi Synthesis and conformational analysis of an alpha-D-mannopyranosyl-(1-->2)-alpha-D-mannopyranosyl-(1-->6)-alpha-D-mannopyranose mimic
    Silvia Mari
    Centro de Investigaciones Biologicas, Departamento de Estructura y Functión de Proteínas, CSIC, C Ramiro de Maeztu 9, 28040 Madrid, Spain
    Carbohydr Res 342:1859-68. 2007
    ..The three-dimensional structure of the molecule was investigated by NMR spectroscopy supported by molecular modelling and was compared to the known features of the natural mannotrioside...
  88. ncbi Pyruvated galactose and oligosaccharides from Erwinia chrysanthemi Ech6 extracellular polysaccharide
    B Y Yang
    Department of Biochemistry, College of Medicine, University of Iowa, Iowa City 52242, USA
    Carbohydr Res 331:59-67. 2001
    ..Y.; Gray, J. S. S.; Montgomery, R. Int. J. Biol. Macromol., 1994, 16, 306-312]...
  89. ncbi Structural basis for the recognition of complex-type biantennary oligosaccharides by Pterocarpus angolensis lectin
    Lieven Buts
    Laboratorium voor Ultrastructuur, Vrije Universiteit Brussel and Department of Molecular and Cellular Interactions, Vlaams Interuniversitair Instituut voor Biotechnologie, Belgium
    FEBS J 273:2407-20. 2006
    ..The core mannose and the GlcNAc beta(1-2)Man moiety on the 1-3 arm on the other hand occupy a series of subsites distinct from those of con A...
  90. ncbi Determination of the site-specific oligosaccharide distribution of the O-glycans attached to the porcine submaxillary mucin tandem repeat. Further evidence for the modulation of O-glycans side chain structures by peptide sequence
    Thomas A Gerken
    Department of Pediatrics, W A Bernbaum Center for Cystic Fibrosis Research, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 277:7736-51. 2002
    ....
  91. ncbi Synthesis of oligosaccharides corresponding to Streptococcus pneumoniae type 9 capsular polysaccharide structures
    Mia Alpe
    Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S 106 91, Stockholm, Sweden
    Carbohydr Res 337:1715-22. 2002
    Two trisaccharides, alpha-D-Galp-(1-->3)-beta-D-ManpNAc-(1-->4)-beta-D-Glcp and alpha-D-Glcp-(1-->3)-beta-D-ManpNAc-(1-->4)-beta-D-Glcp, corresponding to structures from Streptococcus pneumoniae capsular polysaccharides type 9A, L, V and ..
  92. ncbi The hexopyranosyl residue that is C-glycosidically linked to the side chain of tryptophan-7 in human RNase Us is alpha-mannopyranose
    T de Beer
    Bijvoet Center, Department of Bio Organic Chemistry, Utrecht University, The Netherlands
    Biochemistry 34:11785-9. 1995
    ..Furthermore, the nuclear magnetic resonance (NMR) data indicate that the mannopyranose moiety in a glycopeptide derived from RNase U(s) adopts several conformations on the NMR time scale...
  93. ncbi Parasite glycoconjugates. Part 16: Synthesis of a disaccharide and phosphorylated di- and tri-saccharides from Leishmania lipophosphoglycan
    Andrew J Ross
    Faculty of Life Sciences, Division of Biological Chemistry and Molecular Microbiology, University of Dundee, UK
    Carbohydr Res 341:1954-64. 2006
    ..The phosphosaccharides were synthesised using the H-phosphonate method for phosphorylation...
  94. ncbi Synthesis of a core trisaccharide as a versatile building block for N-glycans and glycoconjugates
    Carlo Unverzagt
    Institut fur Organische Chemie und Biochemie, Technische Universitat Munchen, Lichtenbergstrasse 4, 85748 Garching, Germany
    Chemistry 9:1369-76. 2003
    ..The benzylidene protection of the beta-mannoside and the azido group at the reducing end of the core trisaccharide allow modular synthesis of N-glycans and their glycoconjugates...
  95. ncbi Study of interhalogens/silver trifluoromethanesulfonate as promoter systems for high-yielding sialylations
    Andréas Meijer
    Organic and Bioorganic Chemistry, Center for Chemistry and Chemical Engineering, Lund University, P O Box 124, SE 221 00 Lund, Sweden
    J Org Chem 67:7407-12. 2002
    ..By combining these observations, we were able to increase the yield of the model reaction to 97%...
  96. ncbi Identification of a disaccharide (Xyl-Glc) and a trisaccharide (Xyl2-Glc) O-glycosidically linked to a serine residue in the first epidermal growth factor-like domain of human factors VII and IX and protein Z and bovine protein Z
    H Nishimura
    Department of Biology, Faculty of Science, Kyushu University 33, Fukuoka, Japan
    J Biol Chem 264:20320-5. 1989
    ..Whether these carbohydrate moieties contribute to the biological activities of these proteins is unknown...
  97. ncbi Synthetic heparin pentasaccharide depolymerization by heparinase I: molecular and biological implications
    A N Daud
    Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA
    Clin Appl Thromb Hemost 7:58-64. 2001
    ....
  98. ncbi Deconjugation and degradation of flavonol glycosides by pig cecal microbiota characterized by Fluorescence in situ hybridization (FISH)
    Eva Maria Hein
    Institute of Food Chemistry, University of Munster, Corrensstrasse 45, 48149 Munster, Germany
    J Agric Food Chem 56:2281-90. 2008
    ..The intestinal metabolism of di- and trisaccharides was much slower compared to the monoglycosides...
  99. ncbi Efficient chemoenzymatic oligosaccharide synthesis by reverse phosphorolysis using cellobiose phosphorylase and cellodextrin phosphorylase from Clostridium thermocellum
    Hiroyuki Nakai
    Enzyme and Protein Chemistry, Department of Systems Biology, Technical University of Denmark, Søltofts Plads, Building 224, DK 2800 Kgs Lyngby, Denmark
    Biochimie 92:1818-26. 2010
    ..disaccharides with β-(1→4)- regioselectivity from five monosaccharides as well as branched β-glucosyl trisaccharides with β-(1→4)-regioselectivity from three (1→6)-linked disaccharides...
  100. ncbi Comparative study of blood group-recognizing lectins toward ABO blood group antigens on neoglycoproteins, glycoproteins and complex-type oligosaccharides
    T Matsui
    Division of Biomedical Polymer Science, Institute for Comprehensive Medical Science, Fujita Health Univeristy, Toyoake, Aichi, Japan
    Biochim Biophys Acta 1525:50-7. 2001
    ..Human serum albumin conjugated with A- and B-trisaccharides was clearly recognized by Helix pomatia (HPA), Phaseolus lunatus, Dolichos biflorus agglutinins, and Griffonia ..
  101. ncbi Identification and quantitative analysis of stage-specific carbohydrates in loblolly pine (Pinus taeda) zygotic embryo and female gametophyte tissues
    Gerald S Pullman
    Institute of Paper Science and Technology, Georgia Institute of Technology, Atlanta, GA 30332 0620, USA
    Tree Physiol 28:985-96. 2008
    Stage-specific analyses of starch and 18 sugars, including pentoses, hexoses, disaccharides, trisaccharides, oligosaccharides and sugar alcohols, were made throughout seed development for zygotic embryo and female gametophyte (FG) tissues ..

Research Grants35

  1. Photocrosslinking characterization of heat-labile toxin glycoreceptors
    Amberlyn M Wands; Fiscal Year: 2013
    ..capable of binding the blood group A and B antigens, primarily through direct contacts with these terminal trisaccharides. Currently, the role that these non-GM1a ligands play in LTB cell-surface binding/pathogenesis is still ..
  2. FCR DEFICIENT MICE SUSCEPTIBILITY TO PATHOGENS
    JEFFREY VICTOR RAVETCH; Fiscal Year: 2012
    ..SIGN R1, bind to high mannose oligosaccharides, as well as fucose containing glycans, such as the Lewisx trisaccharides. These binding specificities underlie the ability of these molecules to interact with the envelope ..
  3. SYNTHESES APPLICATIONS OF ALPHA GALACTOSYL EPITOPES
    Peng Wang; Fiscal Year: 2002
    ..The most common alpha-Gal epitopes are disaccharide alpha Gal1-3Gal1 (1), trisaccharides alphaGal1-3betaGal1-4betaGlcNAc (2) and alphaGal1-3betaGal1-4betaGlc (3), and pentasaccharide alphaGal1-..
  4. 9-0 ACETYLATED SIALIC ACIDS ON T CELLS
    Laura Martin; Fiscal Year: 2002
    ..These mice are deficient in the sialylated cell-surface trisaccharides produced by each enzyme, and exhibit aspects of immunodeficiency and aberrant T cell survival...
  5. Synthesis of Papulacandins A-D; New Antifungal Analogs
    GEORGE O DOHERTY; Fiscal Year: 2005
    ..synthetic approach to the papulacandin ring system, which should allow for easy access to these di and trisaccharides. In addition, this approach will allow simple access to unnatural analogs of this class of natural products ..
  6. Xenograft-like rejection of tumors in a-gal glycolipids
    URI GALILI GALILI; Fiscal Year: 2010
    ..We will study this treatment in a unique mouse model that simulates the pertinent human immunological parameters. Success in the studies in the mouse model will enable us to apply this treatment to cancer patients. ..
  7. INCREASE/gp120 IMMUNOGENICITY/LINKED ALPHA-GAL EPITOPES
    Uri Galili; Fiscal Year: 2005
    ..We will then also collaborate with a group studying immune responses in monkeys to determine the efficacy of this vaccine in a primate model. ..
  8. PREVENTING ANTI-GAL PRODUCTION AGAINST XENOGRAFTS
    Uri Galili; Fiscal Year: 2003
    ..Success in these studies will help in planning effective treatments for preventing anti-Gal response in primate xenografts recipients. | ..
  9. Role of C-type lectin receptors in food allergy
    Shau Ku Huang; Fiscal Year: 2008
    ..Moreover, binding and functional assays will be performed to investigate the ability of food allergens to target CLRs and modulate DC functions. [unreadable] [unreadable] [unreadable]..
  10. Novel Ribostamycins and SAR Study of Ring III Aminosugar
    Cheng Wei Chang; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  11. International Network and Registry for TMA
    Howard Trachtman; Fiscal Year: 2007
    ..These include essential hypertension, diabetes, hyperlipidemia, myocardial infarction, and chronic kidney disease. [unreadable] [unreadable]..
  12. Epigenetic Alterations in Homeotic Genes
    Fumiichiro Yamamoto; Fiscal Year: 2005
    ..Both the constitutive and inducible expression systems will be used to examine the tumor suppressor function of these homeotic genes. ..
  13. Mechanisms of MMP-3 Action in Acute Lung Injury
    James Varani; Fiscal Year: 2005
    ..These studies will provide an overall understanding of the mechanism(s) by which MMP-3 contributes to acute lung injury. ..
  14. Human monoclonal antibody therapy for HUS
    Howard Trachtman; Fiscal Year: 2004
    ..abstract_text> ..
  15. Male Fertility & Protein Expression in Spermatogenesis
    PAUL RICK; Fiscal Year: 2004
    ..abstract_text> ..
  16. BIOSYNTHESIS OF ENTEROBACTERIAL COMMON ANTIGEN
    PAUL RICK; Fiscal Year: 2004
    ..Such information will also provide a rationale for the development of new antimicrobial agents. ..
  17. Mechanobiology and Regenerative Medicine
    Michael S Sacks; Fiscal Year: 2010
    ..A timeline for completion of these studies, hypotheses to drive the specific aims, alternative approaches for completion of the work, and quantitative criteria for success are provided. ..
  18. Cell Recruitment Induced by ECM Scaffold Degradation
    Stephen F Badylak; Fiscal Year: 2010
    ..The objectives of the studies, the hypothesis upon which the experimental design is based, and a timeline for completion of the studies are presented. ..
  19. SQUAMOUS EPITHELIAL CELL INVASION IN ORGAN CULTURE
    James Varani; Fiscal Year: 2001
    ..abstract_text> ..
  20. TOPICAL RETINOIDS FOR DIABETIC FOOT ULCERS
    James Varani; Fiscal Year: 2003
    ..abstract_text> ..
  21. Rotavirus VP4: Structure and function
    Stephen Harrison; Fiscal Year: 2007
    ..abstract_text> ..
  22. Array-based methylation analysis using anti-5mC antibody
    Fumiichiro Yamamoto; Fiscal Year: 2007
    ..We will evaluate the sensitivity, specificity, and reproducibility of the method, using BAG clone microarrays, DNA fragment microarrays, and oligonucleotide microarrays. [unreadable] [unreadable] [unreadable]..
  23. NEW STRATEGIES FOR GLYCOCONJUGATE SYNTHESIS
    Frank McDonald; Fiscal Year: 2005
    ....
  24. ORIGIN OF CELLS THAT REPOPULATE RESORBABLE ECM SCAFFOLDS
    Stephen Badylak; Fiscal Year: 2003
    ..abstract_text> ..
  25. Regulation of neuronal stem cell death
    Erhard Bieberich; Fiscal Year: 2006
    ..In conclusion, this study will identify mechanisms for regulation of apoptosis by ceramide that are critical for normal brain development and/or the etiology of subsequent, pathological disorders in adulthood. ..
  26. Novel Therapies for Resistant FSGS
    Howard Trachtman; Fiscal Year: 2006
    ..The infrastructure that is established for the performance of this R21/R33 project should prove useful for the efficient assessment of additional novel therapies that will be developed in the future for patients with primary FSGS. ..
  27. New Aminoglycosides to Treat Drug-Resistant Bacteria
    STEVEN SUCHECK; Fiscal Year: 2003
    ..aeruginosa, Enterococci sp., E.coli, and S. aureus. iv) Identify a few promising lead compounds for advancement into in vivo efficacy studies, safety studies and ultimately clinical development. ..
  28. MULTICENTER TRIAL OF SYNSORB PK IN E COLI RELATED HUS
    Howard Trachtman; Fiscal Year: 2003
    ..The outcome of this trial may justify the use of SYNSORB PK as a safe therapy to ameliorate D+HUS. ..
  29. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 2006
    ..As in the past, secreted recombinant proteins with novel structural attributes will be characterized and utilized for collaborative studies of SP-D function. [unreadable] [unreadable]..
  30. Cellular Remodeling of ECM Scaffolds
    Stephen Badylak; Fiscal Year: 2009
    ..We have identified clearly defined specific aims with quantifiable end points and an efficient three year timeline to conduct this work. ..
  31. Mechanisms of ECM Scaffold Remodeling
    Stephen Badylak; Fiscal Year: 2006
    ..The work will be conducted by an experienced interdisciplinary team of scientists and a timeline is presented for completion of the work. ..
  32. ORIGIN OF CELLS THAT REPOPULATE RESORBABLE ECM SCAFFOLDS
    Stephen Badylak; Fiscal Year: 2001
    ..abstract_text> ..
  33. Novel Antirivals for Hantavirus Pulmonary Syndrome
    JEFFREY ARTERBURN; Fiscal Year: 2003
    ..abstract_text> ..