hyaluronic acid


Summary: A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the umbilical cord, in vitreous humor, in synovial fluid, in pathologic joints, in group A and C hemolytic streptococci, and in Wharton's jelly. A high urinary level is found in PROGERIA.

Top Publications

  1. pmc Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4
    Christian Termeer
    Department of Dermatology, University of Freiburg, Freiburg D 79104, Germany
    J Exp Med 195:99-111. 2002
  2. ncbi CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow
    Abraham Avigdor
    Immunology Department, The Weizmann Institute of Science, Rehovot, Israel
    Blood 103:2981-9. 2004
  3. ncbi Hyaluronan: from extracellular glue to pericellular cue
    Bryan P Toole
    Department of Cell Biology and Anatomy, Medical University of South Carolina, 173 Ashley Avenue, Charleston, South Carolina 29425, USA
    Nat Rev Cancer 4:528-39. 2004
  4. doi Hyaluronan in human malignancies
    R K Sironen
    Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, P O Box 1627, FI 70211 Kuopio, Finland
    Exp Cell Res 317:383-91. 2011
  5. pmc Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
    Michael A Jacobetz
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK
    Gut 62:112-20. 2013
  6. pmc Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival
    P Auvinen
    Department of Oncology, Kuopio University Hospital, University of Kuopio, Kuopio, Finland
    Am J Pathol 156:529-36. 2000
  7. ncbi TSG-6 modulates the interaction between hyaluronan and cell surface CD44
    Jayne Lesley
    Molecular and Cell Biology Laboratory, The Salk Institute, San Diego, California 92186, USA
    J Biol Chem 279:25745-54. 2004
  8. doi Involvement of CD44, a molecule with a thousand faces, in cancer dissemination
    David Naor
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Semin Cancer Biol 18:260-7. 2008
  9. doi Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging
    Eun Kyung Lim
    Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120 749, South Korea
    Biomaterials 32:7941-50. 2011
  10. pmc Hyaluronan as an immune regulator in human diseases
    Dianhua Jiang
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Physiol Rev 91:221-64. 2011

Detail Information

Publications413 found, 100 shown here

  1. pmc Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4
    Christian Termeer
    Department of Dermatology, University of Freiburg, Freiburg D 79104, Germany
    J Exp Med 195:99-111. 2002
    Low molecular weight fragmentation products of the polysaccharide of Hyaluronic acid (sHA) produced during inflammation have been shown to be potent activators of immunocompetent cells such as dendritic cells (DCs) and macrophages...
  2. ncbi CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow
    Abraham Avigdor
    Immunology Department, The Weizmann Institute of Science, Rehovot, Israel
    Blood 103:2981-9. 2004
    ..We report that the adhesion receptor CD44 and its major ligand, hyaluronic acid (HA), are essential for homing into the bone marrow (BM) and spleen of nonobese diabetic/severe combined ..
  3. ncbi Hyaluronan: from extracellular glue to pericellular cue
    Bryan P Toole
    Department of Cell Biology and Anatomy, Medical University of South Carolina, 173 Ashley Avenue, Charleston, South Carolina 29425, USA
    Nat Rev Cancer 4:528-39. 2004
  4. doi Hyaluronan in human malignancies
    R K Sironen
    Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, P O Box 1627, FI 70211 Kuopio, Finland
    Exp Cell Res 317:383-91. 2011
    ..Furthermore, intracellular signaling and angiogenesis are affected by the degradation products of hyaluronan. Hyaluronan has also therapeutic implications since it is involved in multidrug resistance...
  5. pmc Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
    Michael A Jacobetz
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK
    Gut 62:112-20. 2013
    ..This study examines the role of an abundant extracellular matrix component, the megadalton glycosaminoglycan hyaluronan (HA), as a novel therapeutic target in PDA...
  6. pmc Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival
    P Auvinen
    Department of Oncology, Kuopio University Hospital, University of Kuopio, Kuopio, Finland
    Am J Pathol 156:529-36. 2000
    ..These results suggest that HA is directly involved in the spreading of breast cancer and may offer a potential target for new therapies...
  7. ncbi TSG-6 modulates the interaction between hyaluronan and cell surface CD44
    Jayne Lesley
    Molecular and Cell Biology Laboratory, The Salk Institute, San Diego, California 92186, USA
    J Biol Chem 279:25745-54. 2004
    ..The ability of TSG-6 to modulate the interaction of hyaluronan with CD44 has important implications for CD44-mediated cell activity at sites of inflammation, where TSG-6 is expressed...
  8. doi Involvement of CD44, a molecule with a thousand faces, in cancer dissemination
    David Naor
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Semin Cancer Biol 18:260-7. 2008
    ..cell line as a model for comprehensive in vitro and in vivo analyses of the interaction between CD44 and hyaluronic acid (HA), and its relevance to tumor dissemination...
  9. doi Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging
    Eun Kyung Lim
    Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120 749, South Korea
    Biomaterials 32:7941-50. 2011
    ..This suggests that HA-MNCs can be a potent cancer specific molecular imaging agent via targeted detection of CD44 with MR imaging...
  10. pmc Hyaluronan as an immune regulator in human diseases
    Dianhua Jiang
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Physiol Rev 91:221-64. 2011
    ..This review focuses on the role of hyaluronan as an immune regulator in human diseases...
  11. pmc Hyaluronan-CD44 interaction promotes c-Src-mediated twist signaling, microRNA-10b expression, and RhoA/RhoC up-regulation, leading to Rho-kinase-associated cytoskeleton activation and breast tumor cell invasion
    Lilly Y W Bourguignon
    Department of Medicine, Endocrine Unit 111N, University of California at San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 285:36721-35. 2010
    ..All of these events are critical prerequisite steps for the acquisition of metastatic properties by human breast cancer cells...
  12. doi The structure of glycosaminoglycans and their interactions with proteins
    Neha S Gandhi
    Western Australian Biomedical Research Institute, Curtin University of Technology, Perth, WA 6845, Australia
    Chem Biol Drug Des 72:455-82. 2008
    ..New approaches to the development of GAG mimetics as possible new glycotherapeutics are also briefly covered...
  13. ncbi Role of hyaluronic acid glycosaminoglycans in shear-induced endothelium-derived nitric oxide release
    Seiichi Mochizuki
    Department of Medical Engineering, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701 0192, Japan
    Am J Physiol Heart Circ Physiol 285:H722-6. 2003
    ..solution at a wide range of perfusion rates with and without pretreatment with hyaluronidase to degrade hyaluronic acid glycosaminoglycans within the glycocalyx layer...
  14. ncbi TSG-6: a multifunctional protein associated with inflammation
    Caroline M Milner
    MRC Immunochemistry Unit, Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK
    J Cell Sci 116:1863-73. 2003
    ..In addition, TSG-6 forms both covalent and non-covalent complexes with inter-alpha-inhibitor (a serine protease inhibitor present at high levels in serum) and potentiates its anti-plasmin activity...
  15. doi Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic® for tumor-targeted delivery of docetaxel
    Hyun Jong Cho
    College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea
    Biomaterials 32:7181-90. 2011
    b>Hyaluronic acid-ceramide (HA-CE)-based self-assembled nanoparticles were developed for intravenous docetaxel (DCT) delivery...
  16. doi Altered hyaluronan biosynthesis in cancer progression
    Naoki Itano
    Department of Molecular Oncology, Division of Molecular and Cellular Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Nagano 390 8621, Japan
    Semin Cancer Biol 18:268-74. 2008
  17. pmc Hyperproduction of hyaluronan in neu-induced mammary tumor accelerates angiogenesis through stromal cell recruitment: possible involvement of versican/PG-M
    Hiroshi Koyama
    Department of Molecular Oncology, Division of Molecular and Cellular Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Nagano, Japan
    Am J Pathol 170:1086-99. 2007
    ..Taken together, these results suggest that hyaluronan overproduction accelerates tumor angiogenesis through stromal reaction, notably in the presence of versican...
  18. ncbi PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization
    Antonietta Salustri
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, Rome 00133, Italy
    Development 131:1577-86. 2004
    ..Thus, PTX3 is a structural constituent of the cumulus oophorus extracellular matrix essential for female fertility...
  19. doi Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis
    Elizaveta Kon
    Biomechanics Laboratory III Clinic, Rizzoli Orthopaedic Institute, Bologna, Italy
    Arthroscopy 27:1490-501. 2011
    The aim of our study is to compare the efficacy of platelet-rich plasma (PRP) and viscosupplementation (hyaluronic acid [HA]) intra-articular injections for the treatment of knee cartilage degenerative lesions and osteoarthritis (OA).
  20. doi Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis--meta-analysis
    R R Bannuru
    Tufts Medical Center, Boston, MA, USA
    Osteoarthritis Cartilage 19:611-9. 2011
    To evaluate the therapeutic trajectory of intra-articular hyaluronic acid (IAHA) vs placebo for knee osteoarthritis (OA).
  21. pmc Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells
    Paul L Bollyky
    Benaroya Research Institute, Seattle, WA 98101, USA
    J Leukoc Biol 86:567-72. 2009
  22. ncbi Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3
    Susanna Karvinen
    Department of Anatomy, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    J Biol Chem 278:49495-504. 2003
  23. ncbi Heparanase, hyaluronan, and CD44 in cancers: a breast carcinoma perspective
    Martin Götte
    Department of Obstetrics and Gynecology, Munster University Hospital, Munster, Germany
    Cancer Res 66:10233-7. 2006
    ..These findings suggest that they may be used as prognostic factors and targets for breast cancer treatment...
  24. ncbi The hyaluronan receptor, CD44
    Clare M Isacke
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
    Int J Biochem Cell Biol 34:718-21. 2002
    ..This has important implication for understanding how mis-regulation of CD44 can contribute to disease pathologies...
  25. pmc The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells
    Sara R Hamilton
    London Regional Cancer Program, London Health Sciences Centre, and the University of Western Ontario, London, and Department of Cardiovascular Research, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 282:16667-80. 2007
    ..Therefore, an effect of CD44 on tumor cell motility may depend in part on its ability to partner with additional proteins, such as cell surface Rhamm...
  26. pmc Hyaluronic acid and thrombin upregulate MT1-MMP through PI3K and Rac-1 signaling and prime the homing-related responses of cord blood hematopoietic stem/progenitor cells
    Neeta Shirvaikar
    Canadian Blood Services R and D, Edmonton, Canada
    Stem Cells Dev 20:19-30. 2011
    ..We found that components of supernatants of leukapheresis products such as hyaluronic acid and thrombin (i) increase the secretion of proMMP-9 and transcription and protein synthesis of MT1-MMP in CB ..
  27. pmc NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury
    Kenshi Yamasaki
    Division of Dermatology, University of California, and Veterans Affairs San Diego Health Care System, San Diego, CA 92161, USA
    J Biol Chem 284:12762-71. 2009
    ..These findings support the hypothesis that hyaluronan works through IL-1beta and the cryopyrin system to signal sterile inflammation...
  28. pmc LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan
    S Banerji
    University of Oxford, Molecular Immunology Group, Nuffield Department of Medicine, John Radcliff Hospital, Headington, Oxford OX3 9DU, United Kingdom
    J Cell Biol 144:789-801. 1999
    ..Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves...
  29. pmc The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44
    H Morrison
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, and University of Karlsruhe, Institute of Genetics, 76021 Karlsruhe, Germany
    Genes Dev 15:968-80. 2001
    ..At low cell density, merlin is phosphorylated, growth permissive, and exists in a complex with ezrin, moesin, and CD44. These data indicate that merlin and CD44 form a molecular switch that specifies cell growth arrest or proliferation...
  30. ncbi Hyaluronan fragments: an information-rich system
    Robert Stern
    Department of Pathology and UCSF Comprehensive Cancer Center, School of Medicine, University of California San Francisco, 513 Parnassus Avenue, S 564, San Francisco, CA 94143 0511, USA
    Eur J Cell Biol 85:699-715. 2006
    ..The vast range of activities of hyaluronan polymers is reviewed here, in order to determine if patterns can be detected that would provide insight into their production and regulation...
  31. pmc Hyaluronan: a constitutive regulator of chemoresistance and malignancy in cancer cells
    Bryan P Toole
    Department of Cell Biology and Anatomy, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Semin Cancer Biol 18:244-50. 2008
    ..Antagonists of hyaluronan-CD44 interaction, especially small hyaluronan oligomers, may be useful in therapeutic strategies aimed at preventing tumor recurrence from these therapy-resistant sub-populations within malignant cancers...
  32. ncbi Regulation of lung injury and repair by Toll-like receptors and hyaluronan
    Dianhua Jiang
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Nat Med 11:1173-9. 2005
    ..Hyaluronan-TLR2 and hyaluronan-TLR4 interactions provide signals that initiate inflammatory responses, maintain epithelial cell integrity and promote recovery from acute lung injury...
  33. pmc Enhanced MSC chondrogenesis following delivery of TGF-β3 from alginate microspheres within hyaluronic acid hydrogels in vitro and in vivo
    Liming Bian
    Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104, United States
    Biomaterials 32:6425-34. 2011
    ..Here, we investigated the co-encapsulation of TGF-β3 containing alginate microspheres with human MSCs in hyaluronic acid (HA) hydrogels towards the development of implantable constructs for cartilage repair...
  34. doi The clinical application of autologous bioengineered skin based on a hyaluronic acid scaffold
    Nicolo Scuderi
    Department of Plastic and Reconstructive Surgery, University Sapienza, Rome, Italy
    Biomaterials 29:1620-9. 2008
    ..The organotypical cultures were designed including an engineered scaffold of a non-woven mesh of hyaluronic acid (HYAFF11)...
  35. ncbi Hyaluronan-cell interactions in cancer and vascular disease
    Bryan P Toole
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 277:4593-6. 2002
  36. pmc Regulation of colonic epithelial repair in mice by Toll-like receptors and hyaluronic acid
    Ling Zheng
    Division of Gastroenterology, Washington University, St Louis, Missouri, USA
    Gastroenterology 137:2041-51. 2009
    ..TLR4 ligands include bacterial lipopolysaccharide and hyaluronic acid, a component of the extracellular matrix...
  37. pmc Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors
    Shanthi Ganesh
    Department of Pharmaceutical Sciences, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Boston, MA 02115, USA
    Biomaterials 34:3489-502. 2013
    ..In the current study, we have engineered and screened a series of CD44 targeting hyaluronic acid (HA) based self-assembling nanosystems for targeted siRNA delivery...
  38. ncbi Hyaluronan: polysaccharide chaos to protein organisation
    A J Day
    Department of Biochemistry, University of Oxford, UK
    Curr Opin Struct Biol 11:617-22. 2001
    ..Various studies on hyaluronan-binding proteins suggest there is considerable diversity in their mode of interaction with hyaluronan, which might result in many different bound conformations of the polysaccharide...
  39. pmc Role of hyaluronan and hyaluronan-binding proteins in human asthma
    Jiurong Liang
    Division of Pulmonary, Allergy and Critical Care Medicine, Duke University School of Medicine, Durham, NC, USA
    J Allergy Clin Immunol 128:403-411.e3. 2011
    ..Hyaluronan fragments stimulate macrophages to produce inflammatory cytokines. We hypothesized that hyaluronan and its receptors would play a role in human asthma...
  40. ncbi Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis
    R C Savani
    Division of Neonatology, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:36770-8. 2001
    ..These data suggest that RHAMM and CD44, through interactions with their ligands, are both important to processes required for the formation of new blood vessels...
  41. ncbi The six hyaluronidase-like genes in the human and mouse genomes
    A B Csoka
    Department of Pathology, School of Medicine, University of California San Francisco, LR 101, 4 Koret Way, San Francisco, CA 94143 0506, USA
    Matrix Biol 20:499-508. 2001
    ..The two beta-exoglycosidases, beta-glucuronidase and beta-N-acetyl glucosaminidase, remove sugars from reducing termini of hyaluronan oligomers, and supplement the hyaluronidases in the catabolism of hyaluronan...
  42. doi Hyaluronic acid immobilized magnetic nanoparticles for active targeting and imaging of macrophages
    Medha Kamat
    Department of Chemistry, Michigan State University, East Lansing, 48824, United States
    Bioconjug Chem 21:2128-35. 2010
    ..In this manuscript, we have designed and synthesized iron oxide based magnetic nanoparticles bearing hyaluronic acid (HA) on the surface to target activated macrophages...
  43. doi Surface modification with fibrin/hyaluronic acid hydrogel on solid-free form-based scaffolds followed by BMP-2 loading to enhance bone regeneration
    Sun Woong Kang
    Department of Biomedical Science, CHA University, Seoul, Republic of Korea
    Bone 48:298-306. 2011
    ..In the present study, the surface of a scaffold fabricated using MHDS was coated with a mixture of fibrin and hyaluronic acid (HA) and used as a vehicle for delivery of both bone morphogenetic protein-2 (BMP-2) and adipose-derived ..
  44. ncbi Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2
    Kristen R Taylor
    Division of Dermatology, University of California, San Diego and Veterans Affairs Medical Center, San Diego, California 92161, USA
    J Biol Chem 282:18265-75. 2007
    ..Taken together, our results define a previously unknown mechanism for initiation of sterile inflammation that involves recognition of released hyaluronan fragments as an endogenous signal of tissue injury...
  45. pmc Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria
    J G Beeson
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Nat Med 6:86-90. 2000
    ..We report here that most P. falciparum isolates from infected placentae can bind to hyaluronic acid, a newly discovered receptor for parasite adhesion that is present on the placental lining...
  46. doi Adhesion, phenotypic expression, and biosynthetic capacity of corneal keratocytes on surfaces coated with hyaluronic acid of different molecular weights
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan, ROC
    Acta Biomater 8:1068-79. 2012
    In ophthalmology, hyaluronic acid (HA) is an important extracellular matrix (ECM) component and is appropriate for use in generating a microenvironment for cell cultivation...
  47. pmc Targeting the tumor microenvironment in cancer: why hyaluronidase deserves a second look
    Clifford J Whatcott
    Clinical Translational Research Division, The Translational Genomics Research Institute, Phoenix, Arizona, USA
    Cancer Discov 1:291-6. 2011
  48. doi Stimulating effects of Bacillus subtilis natto-fermented Radix astragali on hyaluronic acid production in human skin cells
    Mei Fang Hsu
    Institute of Food Science and Technology, National Taiwan University, P O Box 23 14, Taipei, Taiwan, ROC
    J Ethnopharmacol 125:474-81. 2009
    ..Radix astragali, a well-known Chinese herb, which has been traditionally used for skincare, and microbial fermentation is one of the conventional methods for processing Chinese herbs...
  49. pmc Hyaluronic acid hydrogels for biomedical applications
    Jason A Burdick
    Department of Bioengineering, University of Pennsylvania, Philadelphia, 19104, USA
    Adv Mater 23:H41-56. 2011
    b>Hyaluronic acid (HA), an immunoneutral polysaccharide that is ubiquitous in the human body, is crucial for many cellular and tissue functions and has been in clinical use for over thirty years...
  50. pmc Intra-articular injections for the treatment of osteoarthritis: focus on the clinical use of hyaluronic acid
    Tommaso Iannitti
    Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, UK
    Drugs R D 11:13-27. 2011
    ..The use of viscosupplementation, i.e. intra-articular (IA) hyaluronic acid (HA) drug therapy, to treat OA, is growing worldwide, due to important results obtained from several clinical ..
  51. pmc Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells
    Sharon Gerecht
    Harvard Massachusetts Institute of Technology, Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:11298-303. 2007
    ..b>Hyaluronic acid (HA) hydrogels were selected because of the role of HA in early development and feeder layer cultures of ..
  52. pmc Two novel functions of hyaluronidase-2 (Hyal2) are formation of the glycocalyx and control of CD44-ERM interactions
    Cecile Duterme
    Molecular Physiology Research Unit, University of Namur, 5000 Namur, Belgium
    J Biol Chem 284:33495-508. 2009
    ..These effects may be relevant to the purported in vivo tumor-suppressive activity of Hyal2...
  53. doi Nanocarriers for cytoplasmic delivery: cellular uptake and intracellular fate of chitosan and hyaluronic acid-coated chitosan nanoparticles in a phagocytic cell model
    Noha M Zaki
    Department of Pharmaceutics, Faculty of Pharmacy, Ain Shams University, Monazamet El Wehda El Afrikia St, El Abbassia, Cairo, Egypt
    Macromol Biosci 11:1747-60. 2011
    ..The surface decoration with HA profoundly influences the kinetics of cellular uptake, with an at least two orders of magnitude slower kinetics, but also the nature of the binding on the cellular surface...
  54. doi Extrinsic ageing in the human skin is associated with alterations in the expression of hyaluronic acid and its metabolizing enzymes
    T G Tzellos
    2nd Department of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Exp Dermatol 18:1028-35. 2009
    ..Glycosaminoglycans (GAG) and particularly hyaluronic acid (HA) are major components of the cutaneous extracellular matrix involved in tissue repair...
  55. pmc Higher levels of CRP, D-dimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or death
    David R Boulware
    University of Minnesota, Minneapolis, Minnesota, USA
    J Infect Dis 203:1637-46. 2011
    ..Substantial morbidity occurs during the first year of antiretroviral therapy (ART) in persons with advanced human immunodeficiency virus (HIV) disease despite HIV suppression. Biomarkers may identify high-risk groups...
  56. ncbi Hyaluronan binding by cell surface CD44
    J Lesley
    Cancer Biology Laboratory, The Salk Institute, San Diego, California 92186 5800, USA
    J Biol Chem 275:26967-75. 2000
    ..Kinetic studies of binding and dissociation of fluorescein-conjugated hyaluronan indicated that inducing mAb treatment had little effect on the binding kinetics, but dissociation from the cell surface was greatly delayed by inducing mAb...
  57. ncbi The link module from ovulation- and inflammation-associated protein TSG-6 changes conformation on hyaluronan binding
    Charles D Blundell
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford, United Kingdom
    J Biol Chem 278:49261-70. 2003
  58. ncbi Gelatin-chondroitin-hyaluronan tri-copolymer scaffold for cartilage tissue engineering
    Chih Hung Chang
    Institute of Biomedical Engineering, National Taiwan University, 7 Chung Shan South Road, Taipei 100, Taiwan, ROC
    Biomaterials 24:4853-8. 2003
    ..These results show that gelatin/chondroitin sulfate/hyaluronan tri-copolymer has potential for use as a cartilage tissue engineering scaffold...
  59. ncbi Crystal structure of hyaluronidase, a major allergen of bee venom
    Z Markovic-Housley
    Division of Structural Biology Biozentrum University of Basel CH 4056, Basel, Switzerland
    Structure 8:1025-35. 2000
    b>Hyaluronic acid (HA) is the most abundant glycosaminoglycan of vertebrate extracellular spaces and is specifically degraded by a beta-1,4 glycosidase...
  60. ncbi CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Florida 33101, USA
    J Biol Chem 276:7327-36. 2001
  61. ncbi CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Miami, Florida 33101, USA
    J Biol Chem 275:1829-38. 2000
    In this study we have explored the interaction between CD44 (the hyaluronic acid (HA)-binding receptor) and Tiam1 (a guanine nucleotide exchange factor) in metastatic breast tumor cells (SP1 cell line)...
  62. ncbi Inter-alpha-trypsin inhibitor, a covalent protein-glycosaminoglycan-protein complex
    Lisheng Zhuo
    Institute for Molecular Science of Medicine, Aichi Medical University, Nagakute, Aichi 480 1195, Japan
    J Biol Chem 279:38079-82. 2004
  63. pmc Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression
    Lilly Y W Bourguignon
    Department of Medicine, University of California at San Francisco and Endocrine Unit 111N, VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Semin Cancer Biol 18:251-9. 2008
    ..It could also serve as ground work for the future development of new drug targets to inhibit HA/CD44-mediated tumor metastasis and cancer progression...
  64. ncbi Measurement of serum hyaluronic acid in patients with chronic hepatitis C and its relationship to liver histology. Consensus Interferon Study Group
    J G McHutchison
    Division of Gastroenterology Hepatology, Scripps Clinic, La Jolla, California 92037, USA
    J Gastroenterol Hepatol 15:945-51. 2000
    ..have identified serum markers shown to correlate with liver histology, including procollogen III peptide and hyaluronic acid (HA)...
  65. ncbi Signaling properties of hyaluronan receptors
    Eva A Turley
    London Regional Cancer Center, University of Western Ontario, London N6A 4L6, Canada
    J Biol Chem 277:4589-92. 2002
  66. pmc Hyaluronan-dependent pericellular matrix
    Stephen P Evanko
    The Hope Heart Program, Benaroya Research Institute at Virginia Mason, 1201 9th Avenue, Seattle, WA 98101, USA
    Adv Drug Deliv Rev 59:1351-65. 2007
    ..The importance of the pericellular matrix in cellular mechanotransduction and the response to mechanical strain are also discussed...
  67. pmc Role of hyaluronan-mediated CD44 signaling in head and neck squamous cell carcinoma progression and chemoresistance
    Steven J Wang
    Department of Otolaryngology Head and Neck Surgery, University of California at San Francisco, San Francisco, California 94115, USA
    Am J Pathol 178:956-63. 2011
    ..Finally, EGFR-mediated pathways play major roles in the HA/CD44 promotion of chemoresistance in HNSCC. Understanding HA/CD44-mediated signaling pathways may lead to improved treatment of HNSCC...
  68. ncbi Hyaluronan and its catabolic products in tissue injury and repair
    Paul W Noble
    Yale University School of Medicine, Section of Pulmonary and Critical Care Medicine, Department of Medicine, VA Connecticut Healthcare System, LCI 105, 333 Cedar Street, New Haven, CT 06520, USA
    Matrix Biol 21:25-9. 2002
    ..The biological properties of these hyaluronan fragments appear to be distinct from the larger precursor molecules. This review examines the biological role of hyaluronan fragments in tissue injury and repair...
  69. doi Therapeutic trajectory of hyaluronic acid versus corticosteroids in the treatment of knee osteoarthritis: a systematic review and meta-analysis
    Raveendhara R Bannuru
    Tufts University School of Medicine, Boston, MA, USA
    Arthritis Rheum 61:1704-11. 2009
    To compare the efficacy of intraarticular hyaluronic acid with corticosteroids for knee osteoarthritis (OA).
  70. ncbi Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications
    Grigorij Kogan
    Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia
    Biotechnol Lett 29:17-25. 2007
    b>Hyaluronic acid (hyaluronan, HA) is a linear polysaccharide formed from disaccharide units containing N-acetyl-D-glucosamine and glucuronic acid...
  71. ncbi Regulation of MDR1 expression and drug resistance by a positive feedback loop involving hyaluronan, phosphoinositide 3-kinase, and ErbB2
    Suniti Misra
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 280:20310-5. 2005
    ..This pathway may also be important in progression of other malignant characteristics. These results illustrate the potential importance of hyaluronan as a therapeutic target in multidrug-resistant carcinomas...
  72. ncbi Resolution of lung inflammation by CD44
    Priit Teder
    Department of Medicine, Pulmonary and Critical Care Section, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 296:155-8. 2002
    ..This phenotype was partially reversed by reconstitution with CD44+ cells, thus demonstrating a critical role for this receptor in resolving lung inflammation...
  73. ncbi CD44 and its role in inflammation and inflammatory diseases
    Pauline Johnson
    Department of Microbiology and Immunology, 2350 Health Sciences Mall, University of British Columbia, Vancouver, B C, V6T 1Z3, Canada
    Inflamm Allergy Drug Targets 8:208-20. 2009
    ..Here we describe the contributions of CD44 and hyaluronan to an inflammatory response and discuss the role of CD44 in both promoting and resolving inflammation in various mouse models of inflammatory disease...
  74. doi Host tissue interaction, fate, and risks of degradable and nondegradable gel fillers
    Lise Hanne Christensen
    Department of Pathology, Bispebjerg Hospital, University Hospital, Copenhagen, Denmark
    Dermatol Surg 35:1612-9. 2009
    ..Most of the new ones are modified versions of the original collagen and hyaluronic acid gels...
  75. doi Silk fibroin/hyaluronan scaffolds for human mesenchymal stem cell culture in tissue engineering
    Marcos Garcia-Fuentes
    Drug Formulation and Delivery Group, Department of Chemistry and Applied Biosciences, ETH Zurich, CH 8093 Zurich, Switzerland
    Biomaterials 30:5068-76. 2009
    ..In conclusion, our data encourages further exploration of silk fibroin/hyaluronan scaffolds as biomimetic platform for mesenchymal stem cells in tissue engineering...
  76. pmc Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis
    Yoshikazu Hirose
    Laboratory of Cell Growth and Differentiation and Laboratory of Nuclear Signaling, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 109:4263-8. 2012
    b>Hyaluronic acid (HA) has been implicated in the proliferation and metastasis of tumor cells...
  77. ncbi The endothelial glycocalyx protects against myocardial edema
    Bernard M van den Berg
    Department of Medical Physics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Circ Res 92:592-4. 2003
    ..2- to 0.5-microm-thick carbohydrate layer and that its degradation instantly results in notable myocardial tissue edema...
  78. pmc Role of receptor for hyaluronic acid-mediated motility (RHAMM) in low molecular weight hyaluronan (LMWHA)-mediated fibrosarcoma cell adhesion
    Katerina Kouvidi
    Department of Histology Embryology, University of Crete, Heraklion 71003, Greece
    J Biol Chem 286:38509-20. 2011
    Hyaluronan (HA) modulates key cancer cell functions through interaction with its CD44 and receptor for hyaluronic acid-mediated motility (RHAMM) receptors...
  79. pmc Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation
    Russell M L Simpson
    Institute of Nephrology, Cardiff Institute of Tissue Engineering and Repair, Cardiff University Heath Park, United Kingdom
    Am J Pathol 175:1915-28. 2009
    ..In conclusion, the HA pericellular coat is integral but not sufficient to correct for the age-dependent defect in phenotypic conversion...
  80. pmc Acylation of CD44 and its association with lipid rafts are required for receptor and hyaluronan endocytosis
    Sai P Thankamony
    Department of Biochemistry, Rush Medical College, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Biol Chem 281:34601-9. 2006
    ..These results indicate that palmitoylation of CD44 is a critical driving determinant to CD44 association with lipid rafts and, concomitantly, the rates of hyaluronan endocytosis and CD44 turnover from cell surface...
  81. ncbi Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin
    M B Brown
    Department of Pharmacy, King s College London, Franklin Wilkins Building, 150 Stamford Street, London, SE1 9NN, UK
    J Eur Acad Dermatol Venereol 19:308-18. 2005
    b>Hyaluronic acid (HA) is a naturally occurring polyanionic, polysaccharide that consists of N-acetyl-D-glucosamine and beta-glucoronic acid...
  82. pmc Macromer density influences mesenchymal stem cell chondrogenesis and maturation in photocrosslinked hyaluronic acid hydrogels
    I E Erickson
    McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Osteoarthritis Cartilage 17:1639-48. 2009
    ..In this study, we investigated the ability of bone marrow derived mesenchymal stem cells (MSCs) to undergo chondrogenesis in crosslinked methacrylated hyaluronic acid hydrogels (MeHA) of different macromer concentrations (1, 2, and 5%).
  83. doi Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel
    Jing Li
    State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China
    Biomaterials 33:2310-20. 2012
    ..intracellular delivery system of paclitaxel (PTX) was successfully developed based on redox-sensitive hyaluronic acid-deoxycholic acid (HA-ss-DOCA) conjugates...
  84. pmc Quercetin inhibits IL-1β-induced inflammation, hyaluronan production and adipogenesis in orbital fibroblasts from Graves' orbitopathy
    Jin Sook Yoon
    Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
    PLoS ONE 6:e26261. 2011
    ..In conclusion, inhibition of inflammation, hyaluronan production, and adipogenesis by the natural plant product quercetin in vitro provides the basis for further study of its potential use in the treatment of GO...
  85. doi The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin
    Shu Liu
    Department of Biopharmaceutics, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    J Control Release 161:933-41. 2012
    The aim of the present study was to develop novel insulin-loaded microneedle arrays (MNs) fabricated from hyaluronic acid (HA), and characterize their applicability in the transdermal delivery of insulin...
  86. doi Hyaluronic acid derivative-based self-assembled nanoparticles for the treatment of melanoma
    Yu Jin Jin
    College of Pharmacy Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151 742, Republic of Korea
    Pharm Res 29:3443-54. 2012
    b>Hyaluronic acid-ceramide (HACE)-based nanoparticles (NPs) were developed for the targeted delivery of doxorubicin (DOX), and their antitumor efficacy for melanoma was evaluated.
  87. doi Hyaluronic acid-coated nanostructured lipid carriers for targeting paclitaxel to cancer
    Xiao Yan Yang
    The School of Pharmaceutical Science, Shandong University, 44 Wenhua Xi Road, Ji Nan, Shandong Province 250012, China
    Cancer Lett 334:338-45. 2013
    The aim of our study was to develop hyaluronic acid-coated, paclitaxel-loaded, nanostructured lipid carriers (HA-NLCs) prepared via electrostatic attraction for delivering paclitaxel (PTX) to tumors overexpressing CD44...
  88. doi Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: a systematic review and meta-analysis of randomized controlled trials
    Jeffrey Voigt
    Medical Device Consultants of Ridgewood, LLC, 99 Glenwood Road, Ridgewood, NJ 07450, USA
    Wound Repair Regen 20:317-31. 2012
    b>Hyaluronic acid (HA) is a polysaccharide common to most species and is found in many sites in the human body, including the skin and soft tissue...
  89. pmc Hyaluronan production increases the malignant properties of mesothelioma cells
    Y Li
    Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Box 575S 751 23 Uppsala, Sweden
    Br J Cancer 85:600-7. 2001
    ..These results provide evidence for an important role of hyaluronan in the aggressive spread of mesotheliomas in adjacent non-cancerous stromal tissues...
  90. ncbi Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice
    Csaba Fulop
    Section of Connective Tissue Biology, Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Development 130:2253-61. 2003
    ..These results provide clear evidence that TNFIP6 is a key catalyst in the formation of the cumulus extracellular matrix and indispensable for female fertility...
  91. doi The three-dimensional vascularization of growth factor-releasing hybrid scaffold of poly (epsilon-caprolactone)/collagen fibers and hyaluronic acid hydrogel
    Andrew K Ekaputra
    Graduate Program in Bioengineering, NUS Tissue Engineering Program, DSO Kent Ridge Building Level 4, 117510 Singapore
    Biomaterials 32:8108-17. 2011
    ..In an attempt to address these issues, a hybrid mesh of poly (ɛ-caprolactone)-collagen blend (PCL/Col) and hyaluronic acid (HA) hydrogel, Heprasil™ was created via a dual electrodeposition system...
  92. doi Oligosaccharides of hyaluronic acid increased epidermal cell stemness by modulation of integrin expression
    Hye Ryung Choi
    Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea
    J Cosmet Dermatol 11:290-6. 2012
    b>Hyaluronic acid (HA) is an abundant matrix component and is degraded into polymers of various sizes. These generated fragments appear to have properties that affect wound healing of the skin...
  93. pmc Hyaluronic acid promotes angiogenesis by inducing RHAMM-TGFβ receptor interaction via CD44-PKCδ
    Deokbum Park
    School of Biological Sciences, College of Natural Sciences, Kangwon National University, Chuncheon 200 701, Korea
    Mol Cells 33:563-74. 2012
    b>Hyaluronic acid (HA) has been shown to promote angiogenesis. However, the mechanism behind this effect remains largely unknown. Therefore, in this study, the mechanism of HA-induced angiogenesis was examined...
  94. pmc Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform
    Badriprasad Ananthanarayanan
    Department of Bioengineering and California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720, USA
    Biomaterials 32:7913-23. 2011
    ..To address this need, we synthesized brain-mimetic ECMs based on hyaluronic acid (HA) with a range of stiffnesses that encompasses normal and tumorigenic brain tissue and functionalized ..
  95. pmc Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme
    T D Camenisch
    Samuel C Johnson Medical Research Center, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    J Clin Invest 106:349-60. 2000
    ..They also reveal a previously unrecognized pathway for cell migration and invasion that is HA-dependent and involves Ras activation...
  96. ncbi Transperineal injection of hyaluronic acid in anterior perirectal fat to decrease rectal toxicity from radiation delivered with intensity modulated brachytherapy or EBRT for prostate cancer patients
    Pedro J Prada
    Department of Radiation Oncology, Hospital Central de Asturias, Oviedo, Spain
    Int J Radiat Oncol Biol Phys 69:95-102. 2007
    ..We began an investigational trial injecting hyaluronic acid (HA) in the perirectal fat to increase the distance between the prostate and the anterior rectal wall...
  97. ncbi Intracellular hyaluronan in arterial smooth muscle cells: association with microtubules, RHAMM, and the mitotic spindle
    Stephen P Evanko
    Hope Heart Program Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101 2795, USA
    J Histochem Cytochem 52:1525-35. 2004
    ..In permeabilized cells, fluorescein-hyaluronan bound to RHAMM-associated microtubules. These findings suggest novel functions for hyaluronan in cellular physiology...
  98. ncbi Hyaluronan synthesis and degradation in cartilage and bone
    E R Bastow
    Arthritis Research Group, University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, 3052, Victoria, Australia
    Cell Mol Life Sci 65:395-413. 2008
    ..The role and regulation of HA synthesis and degradation in cartilage, bone and skeletal development is discussed...
  99. doi Self-assembled hyaluronic acid nanoparticles for active tumor targeting
    Ki Young Choi
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 130 701, Republic of Korea
    Biomaterials 31:106-14. 2010
    b>Hyaluronic acid nanoparticles (HA-NPs), which are formed by the self-assembly of hydrophobically modified HA derivatives, were prepared to investigate their physicochemical characteristics and fates in tumor-bearing mice after systemic ..
  100. pmc Dynamic compressive loading enhances cartilage matrix synthesis and distribution and suppresses hypertrophy in hMSC-laden hyaluronic acid hydrogels
    Liming Bian
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Tissue Eng Part A 18:715-24. 2012
    ..distribution of cartilage specific matrix, and the hypertrophic differentiation of human MSCs encapsulated in hyaluronic acid (HA) hydrogels during long term culture...
  101. pmc Gene delivery through the use of a hyaluronate-associated intracellularly degradable crosslinked polyethyleneimine
    Peisheng Xu
    Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA
    Biomaterials 30:5834-43. 2009

Research Grants76

  1. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..We propose to develop anionic, partially lipophilic hyaluronic acid derivatives as a simple mechanistically-based treatment for this chronic extraordinarily common dental ..
  2. Role of CD44 in experimental Multiple Sclerosis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..unique CD44v isoforms which promote their interactions with ECs at the BBB via specific ligands, such as hyaluronic acid (HA) and/or osteopontin (OPN). Such an interaction would trigger EC injury and significant damage to the BBB...
  3. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2013
    ..family of 5 kDa semi-synthetic glycosaminoglycan ethers (SAGEs), derived from sulfation and alkylation of hyaluronic acid (HA), that are intrinsically non-anticoagulant...
  4. Alcohol &Antiretrovirals in HIV Infection, Oxidative Stress and Liver Disease
    Marianna K Baum; Fiscal Year: 2012
    ..Hepatocellular injury and function will be determined with plasma levels of ALT, AST, platelets, albumin, hyaluronic acid and total and conjugated bilirubin...
    Jason C Mills; Fiscal Year: 2013
    ..Thus, the experiments proposed may help us begin to understand stem cell response to injury in multiple tissues and diseases. Finally, our new finding that the key drug tamoxifen causes gastric toxicity warrants further study in humans. ..
  6. Effects of lymphangiogenesis stimulation on lung allograft rejection
    Souheil El-Chemaly; Fiscal Year: 2013
    ..In addition, it will pave the way for the development of novel strategies to tret acute rejection in lung transplant recipients. ..
  7. Mechanisms of oxidant-induced chronic bronchitis
    ROSANNA C MALBRAN FORTEZA; Fiscal Year: 2012
  8. Novel Glycosaminoglycan Ethers for Prevention of Metastasis
    Alana L Welm; Fiscal Year: 2011
    ..We propose to develop anionic, partially lipophilic hyaluronic acid derivatives as a synthetic, low anticoagulant, sulfated polysaccharide approach to inhibiting metastatic ..
  9. Immunoglobulin Activation of Fibroblasts
    Terry J Smith; Fiscal Year: 2012
    ..In this proposal, we identify abnormalities in human immune system that underlie development of TAO, and apply these insights to animal models in which treatments can be developed. ..
  10. Regulation of Tumor Associated Macrophages by TGF-beta
    Venkateshwar G Keshamouni; Fiscal Year: 2012
    ..in host derived molecules, including heat shock proteins, double stranded DNA from necrotic tumor cells and Hyaluronic acid that can potentially activate macrophage TLR signaling to trigger anti-tumoral responses...
  11. The Role of Beta-Arrestins 1 and 2 in Rheumatoid Arthritis
    Hongkuan Fan; Fiscal Year: 2010
    ..abstract_text> ..
  12. Leukemia Inhibitory Factor As a Mediator of Primate Ovulation &Oocyte Maturation
    Jon D Hennebold; Fiscal Year: 2013
    ..e., pre-hCG) will be directly exposed to LIF to determine a direct effect of this cytokine on promoting C-OE, reinitiation of meiosis, fertilization, and embryonic development. ..
  13. Novel Glycosaminoglycan Derivatives for Treatment of Bladder Inflammation
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..The ultimate goal of this proposal is to both gain a better understanding of bladder inflammatory pathogenesis, and to provide a safe and effective new treatment for the many patients who suffer from PBS/IC. ..
  14. Development of Cytokine-Inhibiting Gels for Treating Chronic Wounds
    Newell R Washburn; Fiscal Year: 2010
    ..pro-inflammatory cytokines, such as tumor necrosis factor- 1, which have been covalently attached to hyaluronic acid gels...
  15. The role of TNF-Alpha in cutaneous integrity
    Victoria P Werth; Fiscal Year: 2013
    ..This information will facilitate evaluation and development of potential interventions to prevent these extensive and destructive changes in skin. ..
  16. Processing and Preservation of Human Umbilical Cord Stem Cells for Cell Therapeut
    Alfred Bahnson; Fiscal Year: 2010
    ..Wharton's jelly (WJ) surrounds the cord vessels and consists of proteoglycans, collagen, hyaluronic acid and fibroblast-like cells...
  17. Impact of Insufficient Vascular EC-SOD in Pulmonary Hypertension
    EVA NOZIK GRAYCK; Fiscal Year: 2013
    ..These findings will have important implications in a wide range of lung diseases to ultimately improve health outcome for patients with these serious problems. ..
  18. N-acetylglucosamine signaling in fungi
    James B Konopka; Fiscal Year: 2012
    ..albicans and related yeasts will serve as important models for understanding how GlcNAc signaling contributes to human diseases and will also aid in the development of novel therapeutic approaches for pathogenic fungi. ..
  19. A Novel Approach for Biomaterials Assisted Regeneration of Pulp-Dentin Complex
    Satish Alapati; Fiscal Year: 2013
    ..parameters for a novel method to enrich progenitor cells for repair of dental pulp tissue;(2) synthesis of hyaluronic acid analogues that include progenitor pulp cells to promote their proliferation, differentiation, and ..
  20. Host-pathogen signaling in group A streptococcal infection
    Michael R Wessels; Fiscal Year: 2012
    ..regulation of more than 100 genes including those that direct synthesis of key virulence factors such as the hyaluronic acid capsule, streptolysin S, streptokinase, streptodornase, and proteins Mac and GRAB...
  21. Research on inhalation toxicology of environmental chemicals
    ROBERT O'CONNER; Fiscal Year: 2012
    ..abstract_text> ..
  22. Ferritin-Based Molecular Imaging of Cardiac Stem Cell Therapy
    Chun Yuan; Fiscal Year: 2010
    ..Specifically, we will test the ability of the hyaluronic acid-based hydrogel, Extracell, to promote the survival and expansion of hESC derived cardiomyocytes in the ..
    Carole R Mendelson; Fiscal Year: 2013
    ..We propose that these interrelated projects, carried out by a highly interactive research team, will achieve the long-range goals of this Program and contribute to a reduction in the incidence of preterm birth. ..
  24. ABCA3 and the Response to Lung Injury
    Rashmin C Savani; Fiscal Year: 2012
    ..Further, the findings emanating from these studies will be relevant to other severe conditions of the lung (e.g. cystic fibrosis) and liver (e.g. alpha-1-antitrypsin deficiency) that have similar mechanisms of disease. ..
  25. The Endothelial Glycocalyx: Its Structure and Function and as a Mechanotransducer
    John M Tarbell; Fiscal Year: 2013
    ..are coated with a glycocalyx of membrane-bound macromolecules comprised of sulfated proteoglycans, hyaluronic acid, sialic acids, glycocproteins and plasma proteins that adhere to this surface matrix...
  26. Mechanisms of Bladder Cancer Progression
    Vinata B Lokeshwar; Fiscal Year: 2013
    ..b>Hyaluronic acid (HA) is a glycosaminoglycan and HYAL1 is a tumor cell-derived hyaluronidase (HAase) that degrades HA into ..
  27. IDO-silencing Salmonella therapy for the treatment of primary and metastatic PDAC
    Don J Diamond; Fiscal Year: 2013
    ..The long-term objective is to develop shIDO-ST into a suitable, effective therapy for the treatment of patients with advanced inoperable PDAC. ..
  28. Regulation of smooth muscle cell function by CD44 in cardiovascular disease
    ELLEN PURE apos PURE'; Fiscal Year: 2012
    ..The proposed studies will define mechanisms that regulate smooth muscle cell growth and thus provide novel targets for treatment of atherosclerosis and restenosis. ..
  29. Cues for cell-mediated regeneration of elastin matrix in aortic aneurysms
    Anand Ramamurthi; Fiscal Year: 2012
  30. Invasion of glioblastoma multiforme (GBM) cells in organotypic brain slices
    ZEV ARI BINDER; Fiscal Year: 2013
    ..Finally, antibody-mediated inhibition of CD44 binding to hyaluronic acid will be used to determine the effect on cell motility, protrusion dynamics, microenvironment deformations, ..
  31. Invasion of C. neoformans into brain endothelial cells
    Ambrose Y Jong; Fiscal Year: 2012
    ..We demonstrated that C. neoformans CPS1 encoded hyaluronic acid synthase. We also verified that CPS1 was required for C...
  32. New probes for matrix metalloproteinase 13
    Gregg B Fields; Fiscal Year: 2013
    ..In addition, a unique mode of MMP inhibition will be identified. ..
  33. The Role of Acid-active Hyaluronidases in Sperm Function
    ..Of the 6 mammalian hyases that catalyze the breakdown of hyaluronic acid (HA) in the extracellular matrix, 5 are known to be abundantly expressed in the testis...
  34. TSG-6: Novel Regulator of Viral-Induced Hyaluronan Synthesis in Inflamed Airways
    Mark E Lauer; Fiscal Year: 2013
  35. Collagen I, Hyaluronan, and Aging
    May J Reed; Fiscal Year: 2011
    ..A better understanding of aged-related changes in HA in the extracellular matrix will allow for studies that exam the effect of utilizing endogenous and exogenous HA to modulate angiogenesis during tissue repair in vivo. ..
  36. CD44 &Stem Cell Marker (Nanog) in Head and Neck Cancer
    LILLY YW BOURGUIGNON; Fiscal Year: 2013
    ..Thus, this proposed project has potentially important clinical utility for the treatment of Veteran patients with HNSCC;and therefore, it is highly relevant to the VA patient care mission. ..
  37. Multivalent Conjugates of Sonic Hedgehog to Accelerate Diabetic Wound Healing
    WESLEY MICHAEL JACKSON; Fiscal Year: 2012
    ..this technology, we have conjugated Sonic hedgehog (Shh), an important angiogenic factor, to linear chains of hyaluronic acid (HyA), and by varying the ratio of Shh: HyA, we can modulate its ability to activate the Shh pathway...
  38. Cartilage Degeneration and Repair By ADAMTSs and Hyaluronan Binding Proteins
    Anna H Plaas; Fiscal Year: 2013
    ..To achieve these objectives we are using QPCR of fibrogenic and chondrogenic genes, siRNA silencing of gene expression, confocal and 2-photon microscopy of cells and ?CT for quantitative cartilage depth and surface analysis. ..
  39. Aryl Hydrocarbon Receptor Ligands and Thyroid Eye Disease
    Richard P Phipps; Fiscal Year: 2013
    NISSI MARY VARKI; Fiscal Year: 2012
    ..Many more opportunities for intellectual and practical collaborations and synergies have also emerged. These studies will reveal many important functions for glycans in health and disease. ..
  41. Host Defense Mechanisms in Chronic Lung Disease
    Jo Rae Wright; Fiscal Year: 2010
    ..abstract_text> ..
  42. HA in fungal allergic asthma
    Jane M Schuh; Fiscal Year: 2013
    ..The objective of this proposal is to show that changes in pulmonary hyaluronic acid (HA) influence the movement and the function of activated B lymphocytes in the allergic lung and that ..
  43. Asthma Inflammation Research (AIR)
    Serpil C Erzurum; Fiscal Year: 2013
    ..abstract_text> ..
  44. Mediators of Inflammation in Intestinal Injury
    William F Stenson; Fiscal Year: 2013
    ..We propose to treat these mice with intraperitoneal hyaluronic acid and quantify mesenchymal stem cell migration in the small intestine...
  45. Elastogenic Factor Functionalized Electrospun Scaffolds for in vivo Generation of
    CHRISTOPHER A BASHUR; Fiscal Year: 2013
    ..Aim 2C will determine graft patency through autologous transplantation in a rat aorta. The significance of this proposal is in engineering vascular tissue replacements with elastic matrix similar to native tissue. ..
  46. A zebrafish model for studying orbital development and disease
    Alon Kahana; Fiscal Year: 2012
    ..abstract_text> ..
  47. Development of a Biomimetic Vitreous Substitute
    Nathan Ravi; Fiscal Year: 2013
    ..is that we can accomplish this by using water-soluble thiolated synthetic analogues of the collagen and hyaluronic acid, the two primary components of the vitreous...
  48. Hyaluronan in Epidermal Injury Responses
    Edward Maytin; Fiscal Year: 2009
    ..Findings from the research could provide new approaches for dampening epidermal hyperplasia and reducing abnormal cornification, thus providing new opportunities to ameliorate several very common skin diseases. ..
  49. Rotator cuff repair using hyaluronan enriched fascia extracellular matrix
    KATHLEEN ANNE DERWIN; Fiscal Year: 2013
    ..abstract_text> ..
    Terry J Smith; Fiscal Year: 2013
    ..They should directly impact the field of TAO by defining potentially attractive therapeutic targets which can be tested in vitro and can be translated into clinical trials involving patients with this vexing disease. ..
  51. Vibratory Mechanotransduction
    Charles K Webb; Fiscal Year: 2010
    ..increases in the expression of extracellular matrix molecules with antiscarring activity, including hyaluronic acid, decorin, and fibromodulin...
  52. Hyaluronan facilitates hematopoietic recovery following ionizing irradiation
    Sophia K Khaldoyanidi; Fiscal Year: 2010
    ..Together, the obtained results will provide important information regarding the possibility to target the hematopoietic niche by using HA following different doses of ionizing irradiation. ..
  53. The A2a adenosine receptor modulates hyaluronan mediated lung inflammation
    MAUREEN RENEE HORTON; Fiscal Year: 2010
    ..We believe that these studies will provide the pre-clinical basis for the use of A2aR specific agonists in the treatment of inflammatory lung diseases such as idiopathic pulmonary fibrosis, chronic bronchitis and emphysema. ..
  54. Cartilage Innate Immunity in Osteoarthritis
    RU BRYAN; Fiscal Year: 2013
    ..There is a pressing need to identify mediators beyond IL-1 that drive OA progression, in order to develop true and effective disease modifying treatment of this disease. ..
  55. Matrix Regulation of Pulmonary Fibrosis
    PAUL WESLEY NOBLE; Fiscal Year: 2013
    ..4. Identify genomic signatures of matrix-invading fibroblasts from severe pulmonary fibrosis and elucidate the signaling pathways that regulate invasion. ..
  56. The role of the mitotic spindle protein RHAMM in early stage bladder cancer
    RANDOLPH STONE II; Fiscal Year: 2012
    ..One of these biomarkers, RHAMM (receptor for hyaluronic acid mediated motility, also called Hmmr), may also have oncogenic function and thereby play a role in UCC ..
  57. Hyaluronan and CD44 are Novel Targets for Acute Lung injury
    Patrick A Singleton; Fiscal Year: 2013
    ..These studies will yield novel mechanistic insights into HMW- HA's protection from ALI-associated pathobiology and inflammatory lung injury as well as provide novel therapeutic strategies to reduce ALI-mediated lung injury. ..
  58. Anti-angiogenesis of HC-HA Covalent Complex and PTX3 Purified from Fetal Membrane
    Scheffer C G Tseng; Fiscal Year: 2011
    ..Consequently, we may develop new therapeutics based on PTX3 bound to HC"HA to treat many diseases in and beyond ophthalmology where unwanted angiogenesis is detrimental to our vision and health. ..
  59. Multivalent Conjugates for Enhanced Bioactivity of Growth Factor Based Therapies
    KEVIN EDWARD HEALY; Fiscal Year: 2013
    ..Using this approach, w have conjugated Shh to linear chains of hyaluronic acid (HyA), and by varying the ratio of Shh:HyA, we can modulate its ability to activate the Shh pathway...
  60. Targeting Stromal Collagen in Pancreatic Cancer
    Daniel D Von Hoff; Fiscal Year: 2013
  61. CD44 Antagonists in Targeted and Combinational Therapy for Glioblastoma
    Qin Yu; Fiscal Year: 2013
    ..Therefore, this proposal has high biological and clinical relevance and significance, and translational potential. ..
  62. Biodegradable, hyaluronic acid-based microcarriers for mesenchymal stem cell prop
    ISAAC EDWARD ERICKSON; Fiscal Year: 2011
    ..The goal of this proposal is to determine the feasibility of preparing biodegradable and biocompatible microcarriers that can double as a substrate for expanding hMSC in a bioreactor and as a delivery vehicle for localized applications. ..
  63. Host Factors in Regulation of Inflammatory and Fibroproliferative Lung Disease
    PAUL WESLEY NOBLE; Fiscal Year: 2013
    ..Each of these projects shares the common theme that interactions of host factors regulates inflammatory and fibrotic lung diseases. ..
    STEVEN KINCAID; Fiscal Year: 1991
    ..Treatment of osteoarthritic joints with injections of hyaluronic acid has proven to provide short term improvement of clinical signs possibly because of its lubricating properties ..
    Ivo van de Rijn; Fiscal Year: 1999
    ..Group A and C streptococci have the ability to surround themselves with a capsule formed by hyaluronic acid which serves as a virulence factor...
  66. Hyaluronan/CD44 and the Early Endometriotic Lesion
    Robert Schenken; Fiscal Year: 2005
    ..The findings should enable us to predict a woman's risk of developing endometriosis based on endometrial cell CD44 characteristics and suggest new approaches to prevent the disease. ..
  67. Effects of Hyaluronan on Interstitial Convection
    MICHAEL FLESSNER; Fiscal Year: 2007
    ..The results of this research project will provide a basis for future work designed to preserve or enhance the transport characteristics of peritoneal tissue during chronic dialysis. ..
    PAUL KNEPPER; Fiscal Year: 2002
    ..studies and image analysis indicate that POAG is associated with a marked decrease in one glycosaminoglycan, hyaluronic acid, in the trabecular meshwork...
    David Pritchard; Fiscal Year: 1999
    ..In addition, the ability of passively administered antibody to the enzyme to abolish its invasion-enhancing effects will be assessed. ..
    Larry Sherman; Fiscal Year: 2002
    ..of IalphaI and PalphaI from the plasma into the follicle and their subsequent binding to newly synthesized hyaluronic acid (HA) and stabilization of the cumulus extracellular matrix (cECM)...
  71. Aerosolized hyaluronic acid as a treatment for COPD
    Gerard Turino; Fiscal Year: 2006
    ..dose, placebo-controlled clinical study to evaluate the safety of administering repeated doses of aerosolized hyaluronic acid (HA) twice daily over two weeks to subjects with chronic obstructive pulmonary disease (COPD)...
    Rosanna Forteza; Fiscal Year: 2005
    ..Thus, the results of this proposal will not only significantly advance our knowledge of airway biology and asthma, but may have important implications to other mucosal surfaces as well. ..
    RASHMIN SAVANI; Fiscal Year: 1999
    ..Success of this novel therapy would encourage us to examine its possible use in human disease. ..
  74. Growth Factor Treatment for Aged Vocal Folds
    Bernard Rousseau; Fiscal Year: 2010
    ..The goal of this research is to explore the use of growth factors for restoring the delicate balance among extracellular matrix components in the aged vocal fold. ..
  75. Hyaluronan and its Receptors in BPD
    RASHMIN SAVANI; Fiscal Year: 2006
    This proposal focuses on the role of the glycosaminoglycan hyaluronan (hyaluronic acid, HA) and the pulmonary collectins SP-A and SP-D in inflammation and Bronchopulmonary Dysplasia (BPD) in baboon models of preterm birth and ventilation...
  76. Hyaluronan Enriched Fascia ECM for Rotator Cuff Repair
    LIKANG CHIN; Fiscal Year: 2010
    ..Use of such a scaffold for rotator cuff augmentation could restore function of the tendon, alleviate patient pain, and consequently reduce medical costs and work-related losses. ..