dermatan sulfate

Summary

Summary: A naturally occurring glycosaminoglycan found mostly in the skin and in connective tissue. It differs from CHONDROITIN SULFATE A (see CHONDROITIN SULFATES) by containing IDURONIC ACID in place of glucuronic acid, its epimer, at carbon atom 5. (from Merck, 12th ed)

Top Publications

  1. pmc Dermatan sulfate epimerase 1-deficient mice have reduced content and changed distribution of iduronic acids in dermatan sulfate and an altered collagen structure in skin
    Marco Maccarana
    Department of Experimental Medical Science, Biomedical Center D12, Lund University, SE 221 84 Lund, Sweden
    Mol Cell Biol 29:5517-28. 2009
  2. ncbi Functions of chondroitin sulfate/dermatan sulfate chains in brain development. Critical roles of E and iE disaccharide units recognized by a single chain antibody GD3G7
    Anurag Purushothaman
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 282:19442-52. 2007
  3. pmc Mice deficient in N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase are unable to synthesize chondroitin/dermatan sulfate containing N-acetylgalactosamine 4,6-bissulfate residues and exhibit decreased protease activity in bone marrow-derived mast cells
    Shiori Ohtake-Niimi
    Department of Chemistry, Aichi University of Education, Igaya cho, Kariya, Aichi 448 8542, Japan
    J Biol Chem 285:20793-805. 2010
  4. ncbi Mouse development is not obviously affected by the absence of dermatan sulfate epimerase 2 in spite of a modified brain dermatan sulfate composition
    Barbara Bartolini
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Glycobiology 22:1007-16. 2012
  5. pmc Sugar-coating wound repair: a review of FGF-10 and dermatan sulfate in wound healing and their potential application in burn wounds
    Jennifer K Plichta
    Department of Surgery, Burn and Shock Trauma Institute, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Burn Care Res 33:299-310. 2012
  6. pmc Iduronic acid in chondroitin/dermatan sulfate: biosynthesis and biological function
    Anders Malmstrom
    Department of Experimental Medical Science, Biomedical Center D12, Lund University, Lund, Sweden
    J Histochem Cytochem 60:916-25. 2012
  7. ncbi The binding properties of minimal oligosaccharides reveal a common heparan sulfate/dermatan sulfate-binding site in hepatocyte growth factor/scatter factor that can accommodate a wide variety of sulfation patterns
    Jon A Deakin
    Cancer Research UK Glyco Oncology Group, School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Rd, Manchester M20 4BX, United Kingdom
    J Biol Chem 284:6311-21. 2009
  8. ncbi Fibroblast invasive migration into fibronectin/fibrin gels requires a previously uncharacterized dermatan sulfate-CD44 proteoglycan
    Richard A F Clark
    Department of Dermatology, School of Medicine, SUNY at Stony Brook, New York, 11794 8165, USA
    J Invest Dermatol 122:266-77. 2004
  9. ncbi Platelet derived growth factor BB is a ligand for dermatan sulfate chain(s) of small matrix proteoglycans from normal and fibrosis affected fascia
    Ewa M Kozma
    Department of Clinical Chemistry and Laboratory Diagnostics, Medical University of Silesia, Jednosci 8, 41 200 Sosnowiec, Poland
    Biochimie 91:1394-404. 2009
  10. ncbi Vascular dermatan sulfate and heparin cofactor II
    Douglas M Tollefsen
    Washington University Medical School, St Louis, MO, USA
    Prog Mol Biol Transl Sci 93:351-72. 2010

Detail Information

Publications304 found, 100 shown here

  1. pmc Dermatan sulfate epimerase 1-deficient mice have reduced content and changed distribution of iduronic acids in dermatan sulfate and an altered collagen structure in skin
    Marco Maccarana
    Department of Experimental Medical Science, Biomedical Center D12, Lund University, SE 221 84 Lund, Sweden
    Mol Cell Biol 29:5517-28. 2009
    b>Dermatan sulfate epimerase 1 (DS-epi1) and DS-epi2 convert glucuronic acid to iduronic acid in chondroitin/dermatan sulfate biosynthesis...
  2. ncbi Functions of chondroitin sulfate/dermatan sulfate chains in brain development. Critical roles of E and iE disaccharide units recognized by a single chain antibody GD3G7
    Anurag Purushothaman
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 282:19442-52. 2007
    Chondroitin sulfate (CS) and dermatan sulfate (DS) have been implicated in the processes of neural development in the brain...
  3. pmc Mice deficient in N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase are unable to synthesize chondroitin/dermatan sulfate containing N-acetylgalactosamine 4,6-bissulfate residues and exhibit decreased protease activity in bone marrow-derived mast cells
    Shiori Ohtake-Niimi
    Department of Chemistry, Aichi University of Education, Igaya cho, Kariya, Aichi 448 8542, Japan
    J Biol Chem 285:20793-805. 2010
    Chondroitin sulfate (CS) and dermatan sulfate (DS) containing N-acetylgalactosamine 4,6-bissulfate (GalNAc(4,6-SO(4))) show various physiological activities through interacting with numerous functional proteins...
  4. ncbi Mouse development is not obviously affected by the absence of dermatan sulfate epimerase 2 in spite of a modified brain dermatan sulfate composition
    Barbara Bartolini
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Glycobiology 22:1007-16. 2012
    b>Dermatan sulfate epimerase 2 (DS-epi2), together with its homolog DS-epi1, transform glucuronic acid into iduronic acid in DS polysaccharide chains. Iduronic acid gives DS increased chain flexibility and promotes protein binding...
  5. pmc Sugar-coating wound repair: a review of FGF-10 and dermatan sulfate in wound healing and their potential application in burn wounds
    Jennifer K Plichta
    Department of Surgery, Burn and Shock Trauma Institute, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Burn Care Res 33:299-310. 2012
    ..b>Dermatan sulfate (DS) is the most abundant glycosaminoglycan in human wound fluid and has been postulated to be directly ..
  6. pmc Iduronic acid in chondroitin/dermatan sulfate: biosynthesis and biological function
    Anders Malmstrom
    Department of Experimental Medical Science, Biomedical Center D12, Lund University, Lund, Sweden
    J Histochem Cytochem 60:916-25. 2012
    The ability of chondroitin/dermatan sulfate (CS/DS) to convey biological information is enriched by the presence of iduronic acid...
  7. ncbi The binding properties of minimal oligosaccharides reveal a common heparan sulfate/dermatan sulfate-binding site in hepatocyte growth factor/scatter factor that can accommodate a wide variety of sulfation patterns
    Jon A Deakin
    Cancer Research UK Glyco Oncology Group, School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Rd, Manchester M20 4BX, United Kingdom
    J Biol Chem 284:6311-21. 2009
    Heparan sulfate (HS)/heparin and dermatan sulfate (DS) both bind with high affinity to hepatocyte growth factor/scatter factor (HGF/SF) and function as necessary co-factors in vitro...
  8. ncbi Fibroblast invasive migration into fibronectin/fibrin gels requires a previously uncharacterized dermatan sulfate-CD44 proteoglycan
    Richard A F Clark
    Department of Dermatology, School of Medicine, SUNY at Stony Brook, New York, 11794 8165, USA
    J Invest Dermatol 122:266-77. 2004
    ..Here we examined another family of cell surface receptors: the proteoglycans. We found that dermatan sulfate was required for fibroblast migration into a fibronectin/fibrin gel...
  9. ncbi Platelet derived growth factor BB is a ligand for dermatan sulfate chain(s) of small matrix proteoglycans from normal and fibrosis affected fascia
    Ewa M Kozma
    Department of Clinical Chemistry and Laboratory Diagnostics, Medical University of Silesia, Jednosci 8, 41 200 Sosnowiec, Poland
    Biochimie 91:1394-404. 2009
    Structural requirements of the short isoform of platelet derived growth factor BB (PDGF-BB) to bind dermatan sulfate (DS)/chondroitin sulfate (CS) are unknown...
  10. ncbi Vascular dermatan sulfate and heparin cofactor II
    Douglas M Tollefsen
    Washington University Medical School, St Louis, MO, USA
    Prog Mol Biol Transl Sci 93:351-72. 2010
    ..The rate of complex formation increases more than 1000-fold in the presence of dermatan sulfate (DS)...
  11. pmc Chondroitin sulfate "wobble motifs" modulate maintenance and differentiation of neural stem cells and their progeny
    Anurag Purushothaman
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 287:2935-42. 2012
    Chondroitin sulfate/dermatan sulfate (CS/DS) proteoglycans, major components of the central nervous system, have the potential to interact with a wide range of growth factors and neurotrophic factors that influence neuronal migration, ..
  12. ncbi Dermatan sulfate reduces monocyte chemoattractant protein 1 and TGF-β production, as well as macrophage recruitment and myofibroblast accumulation in mice with unilateral ureteral obstruction
    C L R Belmiro
    Laboratorio de Bioquimica e Biologia Celular de Glicoconjugados, Programa de Glicobiologia, Instituto de Bioquimica Medica, Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Brasil
    Braz J Med Biol Res 44:624-33. 2011
    ..Heparin and dermatan sulfate (DS) bind and block P- and L-selectin function in vitro...
  13. ncbi Extracellular matrix adhesion-promoting activities of a dermatan sulfate proteoglycan-associated protein (22K) from bovine fetal skin
    K Lewandowska
    Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106
    J Cell Sci 99:657-68. 1991
    A 22 x 10(3) Mr protein (abbreviated 22K) that copurifies with dermatan sulfate proteoglycans (DS-PGs) following the biochemical fractionation of bovine fetal skin has been evaluated for adhesion-promoting activity in vitro using Balb/c ..
  14. ncbi Plasma and urinary levels of dermatan sulfate and heparan sulfate derived disaccharides after long-term enzyme replacement therapy (ERT) in MPS I: correlation with the timing of ERT and with total urinary excretion of glycosaminoglycans
    Minke H de Ru
    Department of Pediatrics, Amsterdam Lysosome Centre Sphinx, Academic Medical Center, University Hospital of Amsterdam, Amsterdam, The Netherlands
    J Inherit Metab Dis 36:247-55. 2013
    ..type I (MPS I) results in a defective breakdown of the glycosaminoglycans (GAGs) heparan sulfate and dermatan sulfate, which leads to a progressive disease...
  15. ncbi Antithrombotic activity of dermatan sulfate in heparin cofactor II-deficient mice
    Cristina P Vicente
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Blood 104:3965-70. 2004
    Heparin cofactor II (HCII) is a plasma protein that inhibits thrombin rapidly in the presence of dermatan sulfate or heparin...
  16. pmc Characterization of the interaction of interleukin-8 with hyaluronan, chondroitin sulfate, dermatan sulfate and their sulfated derivatives by spectroscopy and molecular modeling
    Annelie Pichert
    Institute of Medical Physics and Biophysics, University of Leipzig, Hartelstr 16 18, D 04107 Leipzig, Germany
    Glycobiology 22:134-45. 2012
    ..However, the extracellular matrix contains other GAGs, such as hyaluronic acid (HA), dermatan sulfate (DS) and chondroitin sulfate (CS), which have so far not been characterized in terms of their distinct ..
  17. ncbi Biosynthesis of chondroitin/dermatan sulfate
    Jeremiah E Silbert
    Department of Veterans Affairs Medical Center, Bedford, Massachusetts 01730, USA
    IUBMB Life 54:177-86. 2002
    Chondroitin sulfate and dermatan sulfate are synthesized as galactosaminoglycan polymers containing N-acetylgalactosmine alternating with glucuronic acid...
  18. ncbi Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis
    Tadahisa Mikami
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 278:36115-27. 2003
    4-O-Sulfation of GalNAc is a high frequency modification of chondroitin sulfate and dermatan sulfate (DS), and three major GalNAc 4-O-sulfotransferases including dermatan 4-O-sulfotransferase-1 (D4ST-1) and chondroitin 4-O-..
  19. ncbi Chondroitin/dermatan sulfate in the central nervous system
    Kazuyuki Sugahara
    Frontier Research Center for Post Genomic Science and Technology, Hokkaido University Graduate School of Life Science, Kita ku, Sapporo, Hokkaido 001 0021, Japan
    Curr Opin Struct Biol 17:536-45. 2007
    ..By contrast, chondroitin sulfate side chains often form hybrid chains with dermatan sulfate and serve as a neural stem cell marker and neurogenic/neuritogenic molecules involved in neural stem cell ..
  20. ncbi Binding of a large chondroitin sulfate/dermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44
    H Kawashima
    Department of Bioregulation, Biomedical Research Center, Osaka University Graduate School of Medicine 2 2, Yamada oka, Suita 565 0871, Japan
    J Biol Chem 275:35448-56. 2000
    ..Thus, proteoglycans sufficiently modified with the appropriate glycosaminoglycans should be able to bind L-selectin, P-selectin, and/or CD44...
  21. pmc Two dermatan sulfate epimerases form iduronic acid domains in dermatan sulfate
    Benny Pacheco
    Department of Experimental Medical Science, Biomedical Center D12, Lund University, Tornavagen 10, SE 221 84 Lund, Sweden
    J Biol Chem 284:9788-95. 2009
    A second dermatan sulfate epimerase (DS-epi2) was identified as a homolog of the first epimerase (DS-epi1), which was previously described by our group...
  22. ncbi Oversulfated dermatan sulfate exhibits neurite outgrowth-promoting activity toward embryonic mouse hippocampal neurons: implications of dermatan sulfate in neuritogenesis in the brain
    Megumi Hikino
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 278:43744-54. 2003
    ..In this study, we assessed neuritogenic potencies of various oversulfated dermatan sulfate (DS) preparations purified from hagfish notochord, the bodies of two kinds of ascidians and embryonic sea ..
  23. ncbi Modern developments in mass spectrometry of chondroitin and dermatan sulfate glycosaminoglycans
    Eugen Sisu
    Department of Biochemistry, Victor Babes University of Medicine and Pharmacy, 300054, Timisoara, Romania
    Amino Acids 41:235-56. 2011
    Chondroitin sulfate (CS) and dermatan sulfate (DS) are special types of glycosaminoglycan (GAG) oligosaccharides able to regulate vital biological functions that depend on precise motifs of their constituent hexose sequences and the ..
  24. ncbi Loss of dermatan sulfate epimerase (DSE) function results in musculocontractural Ehlers-Danlos syndrome
    Thomas Muller
    Department of Pediatrics I, Division of Human Genetics, Innsbruck Medical University, Anichstrasse 35, Innsbruck, Austria
    Hum Mol Genet 22:3761-72. 2013
    The sulfated polysaccharide dermatan sulfate (DS) forms proteoglycans with a number of distinct core proteins. Iduronic acid-containing domains in DS have a key role in mediating the functions of DS proteoglycans...
  25. ncbi Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development
    Beata Filipek-Gorniok
    Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
    Dev Dyn 242:964-75. 2013
    Chondroitin/dermatan sulfate (CS/DS) proteoglycans present in the extracellular matrix have important structural and regulatory functions.
  26. pmc A tandem mass spectrometric approach to determination of chondroitin/dermatan sulfate oligosaccharide glycoforms
    May Joy C Miller
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, R 806, Boston, MA 02118, USA
    Glycobiology 16:502-13. 2006
    b>Dermatan sulfate (DS) chains are variants of chondroitin sulfate (CS) that are expressed in mammalian extracellular matrices and are particularly prevalent in skin...
  27. ncbi Characterization of the dermatan sulfate proteoglycans, DS-PGI and DS-PGII, from bovine articular cartilage and skin isolated by octyl-sepharose chromatography
    H U Choi
    Orthopedic Research Laboratories, Montefiore Medical Center, Bronx, New York 10467
    J Biol Chem 264:2876-84. 1989
    Two forms of dermatan sulfate proteoglycans, called DS-PGI and DS-PGII, have been isolated from both bovine fetal skin and calf articular cartilage and characterized...
  28. pmc Allelic variation of the Lyme disease spirochete adhesin DbpA influences spirochetal binding to decorin, dermatan sulfate, and mammalian cells
    Vivian M Benoit
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Infect Immun 79:3501-9. 2011
    ..protein A (DbpA) promotes bacterial binding to the proteoglycan decorin and to the glycosaminoglycan (GAG) dermatan sulfate. To assess allelic variation of DbpA in GAG-, decorin-, and cell-binding activities, we expressed dbpA ..
  29. ncbi Endocytosis of the dermatan sulfate proteoglycan decorin utilizes multiple pathways and is modulated by epidermal growth factor receptor signaling
    David Denis Sofeu Feugaing
    Department of Obstetrics and Gynecology, Domagkstr 11, Munster University Hospital, D 48149 Munster, Germany
    Biochimie 89:637-57. 2007
    ..Of note, lipid-raft-dependent EGFR signaling modulates decorin uptake, suggesting the presence of a potential feedback regulation mechanism for desensitization of signaling events mediated by decorin...
  30. ncbi Matrix localization of tissue factor pathway inhibitor-2/matrix-associated serine protease inhibitor (TFPI-2/MSPI) involves arginine-mediated ionic interactions with heparin and dermatan sulfate: heparin accelerates the activity of TFPI-2/MSPI toward plas
    Y Liu
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, 77030, USA
    Arch Biochem Biophys 370:112-8. 1999
    ..We found that TFPI-2/MSPI bound specifically to heparin and dermatan sulfate. Interaction of these two glycosaminoglycans (GAGs) with TFPI-2/MSPI involved one or more common protein ..
  31. ncbi Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum. Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases
    Chie Mitsunaga
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 281:18942-52. 2006
    Chondroitin sulfate/dermatan sulfate (CS/DS) chains regulate the development of the central nervous system in vertebrates...
  32. pmc Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma
    Martin A Thelin
    Department of Experimental Medical Science, Biomedical Center D12, Lund University, Lund, Sweden
    Cancer Res 72:1943-52. 2012
    ..Chondroitin/dermatan sulfate (CS/DS) proteoglycans, which occur both in the matrix and at the cell surface, play important roles in these ..
  33. ncbi Demonstration of the pleiotrophin-binding oligosaccharide sequences isolated from chondroitin sulfate/dermatan sulfate hybrid chains of embryonic pig brains
    Xingfeng Bao
    Department of Biochemistry, Kobe Pharmaceutical University, 4 19 1, Motoyama kita machi, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 280:35318-28. 2005
    Mammalian brains contain significant amounts of chondroitin sulfate (CS), dermatan sulfate (DS), and CS/DS hybrid chains...
  34. pmc Secondary storage of dermatan sulfate in Sanfilippo disease
    William C Lamanna
    Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California 92093 0687, USA
    J Biol Chem 286:6955-62. 2011
    ..In this article, we describe the accumulation of dermatan sulfate as a novel secondary metabolite in Sanfilippo...
  35. ncbi Structural and conformational aspects of the anticoagulant and anti-thrombotic activity of heparin and dermatan sulfate
    Benito Casu
    Ronzoni Institute for Chemical and Biochemical Research, Milan, Italy
    Curr Pharm Des 10:939-49. 2004
    Heparin and other iduronic acid-containing glycosaminoglycans (GAG) such as dermatan sulfate exert their anticoagulant properties primarily by accelerating the rate of inhibition of the natural protease inhibitors antithrombin III (AT, ..
  36. pmc FGF-10 and specific structural elements of dermatan sulfate size and sulfation promote maximal keratinocyte migration and cellular proliferation
    Katherine A Radek
    Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA
    Wound Repair Regen 17:118-26. 2009
    ..b>Dermatan sulfate (DS) exhibited greater potency than heparan sulfate or other chondroitin sulfates found in wounds...
  37. ncbi Dermatan sulfate binds and potentiates activity of keratinocyte growth factor (FGF-7)
    Janet M Trowbridge
    Division of Dermatology, Department of Medicine, University of California and Veterans Affairs Medical Center, San Diego, California 92161, USA
    J Biol Chem 277:42815-20. 2002
    ..In this investigation we compared the relative activity of heparan sulfate and chondroitin sulfate B (dermatan sulfate), glycosaminoglycans that are present in wounds...
  38. ncbi Evaluation of heparin cofactor II-thrombin complex as a biomarker on blood spots from mucopolysaccharidosis I, IIIA and IIIB mice
    Kia Langford-Smith
    MPS Stem Cell Research Group, Faculty of Medical and Human Sciences, University of Manchester, 3 721 Stopford Building, Manchester M13 9PT, UK
    Mol Genet Metab 99:269-74. 2010
    ..With careful sample preparation, HCII-T ELISA could prove to be a useful biomarker for both newborn screening and measurement of treatment outcomes in selected MPS diseases...
  39. ncbi Molecular cloning and expression of a second chondroitin N-acetylgalactosaminyltransferase involved in the initiation and elongation of chondroitin/dermatan sulfate
    Toru Uyama
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 278:3072-8. 2003
    ..for understanding the biosynthetic mechanisms leading to the selective chain assembly of chondroitin/dermatan sulfate on the linkage region tetrasaccharide common to various proteoglycans containing chondroitin/dermatan sulfate ..
  40. ncbi Structural and sequence motifs in dermatan sulfate for promoting fibroblast growth factor-2 (FGF-2) and FGF-7 activity
    Kristen R Taylor
    Division of Dermatology, University of California, San Diego and Veterans Affairs Medical Center, San Diego, CA 92161, USA
    J Biol Chem 280:5300-6. 2005
    ..In contrast, although dermatan sulfate participates in many of the same biological processes as heparin and heparan sulfate, the interactions of ..
  41. ncbi Novel 70-kDa chondroitin sulfate/dermatan sulfate hybrid chains with a unique heterogeneous sulfation pattern from shark skin, which exhibit neuritogenic activity and binding activities for growth factors and neurotrophic factors
    Chilkunda D Nandini
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 280:4058-69. 2005
    Chondroitin sulfate (CS) and dermatan sulfate (DS) hybrid chains of proteoglycans are critical in growth factor binding, neuritogenesis, and brain development...
  42. ncbi Chondroitin sulfate/dermatan sulfate hybrid chains from embryonic pig brain, which contain a higher proportion of L-iduronic acid than those from adult pig brain, exhibit neuritogenic and growth factor binding activities
    Xingfeng Bao
    Department of Biochemistry, Kobe Pharmaceutical University, Japan
    J Biol Chem 279:9765-76. 2004
    We have shown that over-sulfated chondroitin sulfate/dermatan sulfate (CS/DS) chains from various marine organisms exhibit growth factor binding activities and neurite outgrowth-promoting activities in embryonic mouse hippocampal neurons ..
  43. ncbi Sulfotransferases in glycosaminoglycan biosynthesis
    Marion Kusche-Gullberg
    Department of Medical Biochemistry and Microbiology, The Biomedical Center, Box 582, SE 751 23, Uppsala, Sweden
    Curr Opin Struct Biol 13:605-11. 2003
    ..Gene targeting in mice as well as studies in Drosophila melanogaster and Caenorhabditis elegans have shown that dysfunction or lack of glycosaminoglycan sulfotransferases may result in severely disturbed embryonic development...
  44. ncbi Potential therapeutic application of chondroitin sulfate/dermatan sulfate
    Shuhei Yamada
    Laboratory of Proteoglycan Signaling and Therapeutics, Frontier Research Center for Post Genomic Science and Technology, Hokkaido University Graduate School of Life Science, Nishi 11 choume, Kita 21 jo, Kita ku, Sapporo, Hokkaido 001 0021, Japan
    Curr Drug Discov Technol 5:289-301. 2008
    ..Major GAGs include heparin (Hep)/heparan sulfate, and chondroitin sulfate (CS)/dermatan sulfate (DS)...
  45. ncbi Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate
    Toru Uyama
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 277:8841-6. 2002
    ..of chondroitin sulfate and is the key enzyme responsible for the selective chain assembly of chondroitin/dermatan sulfate on the linkage region tetrasaccharide common to various proteoglycans containing chondroitin/dermatan sulfate ..
  46. ncbi Improved metabolic correction in patients with lysosomal storage disease treated with hematopoietic stem cell transplant compared with enzyme replacement therapy
    Robert F Wynn
    Department of Haematology and BMT, Royal Manchester Children s Hospital, Manchester, United Kingdom
    J Pediatr 154:609-11. 2009
    ..These data might support the wider application of hematopoietic stem cell transplant in the treatment of lysosomal storage disorders...
  47. ncbi Neuritogenic activity of chondroitin/dermatan sulfate hybrid chains of embryonic pig brain and their mimicry from shark liver. Involvement of the pleiotrophin and hepatocyte growth factor signaling pathways
    Fuchuan Li
    Graduate School of Life Science, Hokkaido University, Sapporo 001 0021, Japan
    J Biol Chem 282:2956-66. 2007
    Accumulating evidence suggests the involvement of chondroitin sulfate (CS) and dermatan sulfate (DS) hybrid chains in the brain's development and critical roles for oversulfated disaccharides and IdoUA residues in the growth factor-..
  48. ncbi A unique dermatan sulfate-like glycosaminoglycan from ascidian. Its structure and the effect of its unusual sulfation pattern on anticoagulant activity
    M S Pavão
    Departamento de Bioquimica, Universidade Federal do Rio de Janeiro, Brazil
    J Biol Chem 270:31027-36. 1995
    A dermatan sulfate, similar to the mammalian glycosaminoglycans but not identical with any of them, has been isolated from the body of the ascidian Ascidia nigra...
  49. ncbi Compositional and structural alterations of chondroitin and dermatan sulfates during the progression of atherosclerosis and aneurysmal dilatation of the human abdominal aorta
    Achilleas D Theocharis
    Laboratory of Biochemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Department of Chemistry, University of Patras, 26110 Patras, Greece
    Biochimie 84:667-74. 2002
    ..in the concentration and the structural characteristics of galactosaminoglycans--chondroitin sulfate (CS) and dermatan sulfate (DS)--during the progression of atherosclerosis and aneurysmal dilatation of the human abdominal aorta...
  50. ncbi A functional dermatan sulfate epitope containing iduronate(2-O-sulfate)alpha1-3GalNAc(6-O-sulfate) disaccharide in the mouse brain: demonstration using a novel monoclonal antibody raised against dermatan sulfate of ascidian Ascidia nigra
    Xingfeng Bao
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Japan
    J Biol Chem 280:23184-93. 2005
    Oversulfated chondroitin sulfate (CS), dermatan sulfate (DS), and CS/DS hybrid structures bind growth factors, promote the neurite outgrowth of hippocampal neurons in vitro, and have been implicated in the development of the brain...
  51. ncbi Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2
    Marco Maccarana
    Department of Experimental Medical Science, Lund University, BMC C13, SE 221 84 Lund, Sweden
    J Biol Chem 281:11560-8. 2006
    ..1.3.19) that converts D-glucuronic acid to L-iduronic acid residues in dermatan sulfate biosynthesis...
  52. ncbi Hepatocyte growth factor/scatter factor binds with high affinity to dermatan sulfate
    M Lyon
    Cancer Research Campaign and University of Manchester, Department of Medical Oncology, Christie Hospital National Health Service Trust, Manchester M20 4BX, United Kingdom
    J Biol Chem 273:271-8. 1998
    ..by affinity chromatography that hepatocyte growth factor/scatter factor (HGF/SF) binds strongly to dermatan sulfate (DS), with a similar ionic strength dependence to that previously seen with heparan sulfate (HS)...
  53. ncbi Additive thrombin inhibition by fast moving heparin and dermatan sulfate explains the anticoagulant effect of sulodexide, a natural mixture of glycosaminoglycans
    Benilde Cosmi
    Divisione di Angiologia e Malattie della Coagulazione, Policlinico S Orsola Malpighi, Universita degli Studi di Bologna, Bologna, Italy
    Thromb Res 109:333-9. 2003
    The aim of the study was to evaluate the mechanism of the anticoagulant action of sulodexide, a mixture of glycosaminoglycans (GAGs) composed of dermatan sulfate (DS) and fast moving heparin (FMH), in vitro.
  54. ncbi Effects of low molecular weight heparin in obstructed kidneys: decrease of collagen, fibronectin and TGF-beta, and increase of chondroitin/dermatan sulfate proteoglycans and macrophage infiltration
    Inah M D Pecly
    Laboratório de Tecido Conjuntivo, Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Brazil
    Nephrol Dial Transplant 21:1212-22. 2006
    ..Here we investigate molecular and cellular events involved in the protective effects of heparin in the progression of renal disease after unilateral ureteral obstruction...
  55. ncbi Detection and quantification of sulfated disaccharides from keratan sulfate and chondroitin/dermatan sulfate during chick corneal development by ESI-MS/MS
    Yuntao Zhang
    Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    Invest Ophthalmol Vis Sci 46:1604-14. 2005
    To identify and quantify changes in keratan sulfate (KS) and chondroitin/dermatan sulfate (CS/DS) sulfated disaccharides in the developing chick cornea using electrospray ionization tandem mass spectrometry (ESI-MS/MS).
  56. ncbi The management of patients with heparin-induced thrombocytopenia who require anticoagulant therapy
    Kathryn Hassell
    University of Colorado Health Sciences Center, 4200 East Ninth Ave, C 222, Denver, CO 80262, USA
    Chest 127:1S-8S. 2005
    ..Except for a few clinical situations, it is generally possible to avoid heparin reexposure in patients with a history of HIT...
  57. ncbi Combining (1)H NMR spectroscopy and chemometrics to identify heparin samples that may possess dermatan sulfate (DS) impurities or oversulfated chondroitin sulfate (OSCS) contaminants
    Qingda Zang
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    J Pharm Biomed Anal 54:1020-9. 2011
    ..In addition, naturally occurring dermatan sulfate (DS) was found to be present in these and other heparin samples as an impurity due to incomplete purification...
  58. ncbi Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate
    Benny Pacheco
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Glycobiology 19:1197-203. 2009
    Chondroitin/dermatan sulfate is a highly complex linear polysaccharide ubiquitously found in the extracellular matrix and at the cell surface...
  59. ncbi Heparan sulfate and dermatan sulfate derived disaccharides are sensitive markers for newborn screening for mucopolysaccharidoses types I, II and III
    Jessica de Ruijter
    Department of Pediatrics and Amsterdam Lysosome Centre Sphinx, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Mol Genet Metab 107:705-10. 2012
    ....
  60. ncbi cDNA clone to chick corneal chondroitin/dermatan sulfate proteoglycan reveals identity to decorin
    W Li
    Department of Ophthalmology, Eye and Ear Institute of Pittsburgh, University of Pittsburgh School of Medicine, Pennsylvania 15213
    Arch Biochem Biophys 296:190-7. 1992
    ..A 19-amino-acid match with sequence from the N-terminus of core protein from the corneal chondroitin/dermatan sulfate proteoglycan confirmed the clone as a corneal proteoglycan and the homology with human and bovine decorin ..
  61. ncbi Antithrombotic and anticomplementary properties of a very low molecular mass dermatan sulfate
    María Fabiana Alberto
    Academia Nacional de Medicina, Avenida Las Heras 3092, C1425AUM Ciudad Autónoma de Buenos Aires, Argentina
    Thromb Res 122:109-16. 2008
    b>Dermatan sulfate, a sulfated glycosaminoglycan, acts as an anticoagulant by accelerating the inhibition of thrombin by heparin cofactor II.
  62. ncbi Heparin cofactor IIOslo. Mutation of Arg-189 to His decreases the affinity for dermatan sulfate
    M A Blinder
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 264:5128-33. 1989
    Heparin and dermatan sulfate increase the rate of inhibition of thrombin by heparin cofactor II (HCII) approximately 1000-fold by providing a catalytic template to which both the inhibitor and the proteinase bind...
  63. ncbi Embryos of the sea urchin Strongylocentrotus purpuratus synthesize a dermatan sulfate enriched in 4-O- and 6-O-disulfated galactosamine units
    A C Vilela-Silva
    , , Caixa Postal 68041, Rio de Janeiro, RJ, 21941-590, Brazil
    Glycobiology 11:433-40. 2001
    ..after fertilization this polysaccharide disappears, but 24 h later the embryos synthesize high amounts of dermatan sulfate concomitantly with the mesenchyme blastula-early gastrula stage when the larval gut is forming...
  64. ncbi Low molecular mass dermatan sulfate modulates endothelial cells proliferation and migration
    Rita Yanina Rasente
    Biological Science Department, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina
    Carbohydr Res 356:233-7. 2012
    Low molecular mass dermatan sulfate, obtained by depolymerization, induced the entrance in S phase of mitosis, enhanced the activity of matrix metalloproteinase-2, and could modulate cell migration of endothelial cells, through mechanisms ..
  65. ncbi Primary mesenchyme cell migration requires a chondroitin sulfate/dermatan sulfate proteoglycan
    M C Lane
    Department of Biology, University of Iowa, Iowa City 52242
    Dev Biol 143:389-97. 1991
    ..affects the synthesis by the primary mesenchyme cells of a very large, cell surface chondroitin sulfate/dermatan sulfate proteoglycan...
  66. ncbi Dermatan sulfate and heparan sulfate as a biomarker for mucopolysaccharidosis I
    Shunji Tomatsu
    Department of Pediatrics, Saint Louis University, St Louis, MO 63104, USA
    J Inherit Metab Dis 33:141-50. 2010
    ..disorder caused by deficiency of alpha-L-iduronidase leading to accumulation of its catabolic substrates, dermatan sulfate (DS) and heparan sulfate (HS), in lysosomes...
  67. ncbi The amino acid tryptophan prevents the biosynthesis of dermatan sulfate
    Christine Herzog
    Institute of Physiological Chemistry and Pathobiochemistry, University Hospital Munster, 48149 Munster, Germany
    Mol Biosyst 7:2872-81. 2011
    ..As a consequence of the conversion of chondroitin sulfate (CS) to dermatan sulfate (DS), the glycosaminoglycans become more flexible and enable DS to perform more sophisticated signaling ..
  68. ncbi Dermatan sulfate epimerase 2 is the predominant isozyme in the formation of the chondroitin sulfate/dermatan sulfate hybrid structure in postnatal developing mouse brain
    Chizuru Akatsu
    Laboratory of Proteoglycan Signaling and Therapeutics, Hokkaido University Graduate School of Life Science, Sapporo, Japan
    Glycobiology 21:565-74. 2011
    Chondroitin sulfate (CS) and dermatan sulfate (DS) are expressed in significant amounts in the brain and play important roles in the development of the central nervous system in mammals...
  69. ncbi beta-Amyloid fibrillation and/or hyperhomocysteinemia modify striatal patterns of hyaluronic acid and dermatan sulfate: Possible role in the pathogenesis of Alzheimer's disease
    S Genedani
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Italy
    Curr Alzheimer Res 7:150-7. 2010
    ..8%) in the hyaluronic acid (HA) percentage and an increase (+14.5%) in the dermatan sulfate (DS) with a total charge density increasing of 14.9%. A significant decrease (-19...
  70. ncbi Characterization and binding activity of the chondroitin/dermatan sulfate chain from Endocan, a soluble endothelial proteoglycan
    Stéphane Sarrazin
    Institut de Biologie Structurale, UMR 5075 CNRS CEA UJF, 41 Rue Horowitz, 38027 Grenoble, France
    Glycobiology 20:1380-8. 2010
    Endocan is a recently identified soluble chondroitin/dermatan sulfate (CS/DS) proteoglycan...
  71. ncbi The secreted serine protease xHtrA1 stimulates long-range FGF signaling in the early Xenopus embryo
    Shirui Hou
    Department of Developmental Biochemistry, Institute of Biochemistry and Cell Biology, Georg August University Gottingen, 37077 Gottingen, Germany
    Dev Cell 13:226-41. 2007
    ..Xenopus Biglycan, Syndecan-4, and Glypican-4 are proteolytic targets of xHtrA1 and that heparan sulfate and dermatan sulfate trigger posteriorization, mesoderm induction, and neuronal differentiation via the FGF signaling pathway...
  72. pmc The dermatan sulfate proteoglycan decorin modulates α2β1 integrin and the vimentin intermediate filament system during collagen synthesis
    Oliver Jungmann
    Insitute of Physiological Chemistry and Pathobiochemistry, University Hospital Munster, Munster, Germany
    PLoS ONE 7:e50809. 2012
    Decorin, a small leucine-rich proteoglycan harboring a dermatan sulfate chain at its N-terminus, is involved in regulating matrix organization and cell signaling...
  73. ncbi Effect of dermatan sulfate glycosaminoglycans on the quasi-static material properties of the human medial collateral ligament
    Trevor J Lujan
    Department of Bioengineering, University of Utah, 50 South Central Campus Drive, Room 2480, Salt Lake City, UT 84112, USA
    J Orthop Res 25:894-903. 2007
    The glycosaminoglycan of decorin, dermatan sulfate (DS), has been suggested to contribute to the mechanical properties of soft connective tissues such as ligaments and tendons...
  74. ncbi Ascidian dermatan sulfates attenuate metastasis, inflammation and thrombosis by inhibition of P-selectin
    E O Kozlowski
    Institute of Physiology, University of Zürich and Zürich Center for Integrative Human Physiology, Zurich, Switzerland
    J Thromb Haemost 9:1807-15. 2011
    ..P-selectin-mediated platelet-tumor cell and tumor cell-endothelium interactions facilitate the initial steps of metastasis...
  75. ncbi Recent advances in the structural study of functional chondroitin sulfate and dermatan sulfate in health and disease
    Christina Malavaki
    Laboratory of Proteoglycan Signaling and Therapeutics, Hokkaido University Graduate School of Life Science, Sapporo, Japan
    Connect Tissue Res 49:133-9. 2008
    Chondroitin sulfate (CS) dermatan sulfate (DS), and CS/DS hybrid chains are biologically active like heparan sulfate, and structurally the most complex species of the glycosaminoglycan family along with heparan sulfate...
  76. pmc Vascular dermatan sulfate regulates the antithrombotic activity of heparin cofactor II
    Li He
    Division of Hematology, Washington University Medical School, 660 South Euclid Ave, St Louis, MO 63110, USA
    Blood 111:4118-25. 2008
    ..b>Dermatan sulfate (DS) and heparan sulfate (HS) increase the rate of inhibition of thrombin by HCII in vitro, but it is unknown ..
  77. ncbi Differential gene expression of multiple chondroitin sulfate modification enzymes among neural stem cells, neurons and astrocytes
    Shinobu Yamauchi
    Department of Legal Medicine, Dokkyo Medical University, 880 Kita Kobayashi, Mibu, Tochigi 321 0293, Japan
    Neurosci Lett 493:107-11. 2011
    Chondroitin sulfate/dermatan sulfate (CS/DS) polysaccharides have been reported to play a crucial role in the proliferation and maintenance of neural stem cells (NSCs)...
  78. pmc Dermatan sulfate interacts with dead cells and regulates CD5(+) B-cell fate: implications for a key role in autoimmunity
    Julia Y Wang
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Pathol 178:2168-76. 2011
    ..This study demonstrates that dermatan sulfate (DS) expands the B-1a cell population and augments the specific antibody response to an antigen when it is in ..
  79. ncbi The catalytic machinery of chondroitinase ABC I utilizes a calcium coordination strategy to optimally process dermatan sulfate
    Vikas Prabhakar
    Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Biochemistry 45:11130-9. 2006
    The chondroitinases are bacterial lyases that specifically cleave chondroitin sulfate and/or dermatan sulfate glycosaminoglycans...
  80. ncbi N-Acetylgalactosamine 4,6-O-sulfate residues mediate binding and activation of heparin cofactor II by porcine mucosal dermatan sulfate
    Anna Margrét Halldórsdóttir
    Division of Laboratory Medicine, Department of Pathology and Immunology, Campus Box 8118, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Glycobiology 16:693-701. 2006
    b>Dermatan sulfate (DS) accelerates the inhibition of thrombin by heparin cofactor II (HCII)...
  81. ncbi Regulation of the chondroitin/dermatan fine structure by transforming growth factor-beta1 through effects on polymer-modifying enzymes
    Kerstin Tiedemann
    Physiological Sciences, Lund University, BMC B11, S 221 84 Lund, Sweden
    Glycobiology 15:1277-85. 2005
    The chondroitin/dermatan sulfate proteoglycans (CS/DSPGs), biglycan, decorin, and versican play several important roles in extracellular matrix influencing matrix organization, cell proliferation, and recruitment...
  82. ncbi Effects of glycosaminoglycans on cell proliferation of normal osteoblasts and human osteosarcoma cells depend on their type and fine chemical compositions
    D Nikitovic
    Department of Histology, School of Medicine, University of Crete, 71003 Heraklion, Greece
    Anticancer Res 25:2851-6. 2005
    ..This effect is closely related to the fine chemical structure of GAGs, i.e. the presence of L-iduronic acid and the degree of sulphation...
  83. ncbi Anti-tumor activities of chondroitinase AC and chondroitinase B: inhibition of angiogenesis, proliferation and invasion
    E M Denholm
    Department of Cellular Biology, IBEX Pharmaceuticals, Inc, 5485 Pare, H4P 1P7, Montreal, Quebec, Canada
    Eur J Pharmacol 416:213-21. 2001
    ..chondroitinase AC and chondroitinase B, were utilized to examine the roles of chondroitin sulfates and dermatan sulfate in tumor metastasis and angiogenesis...
  84. ncbi Dermatan sulfate is the predominant antithrombotic glycosaminoglycan in vessel walls: implications for a possible physiological function of heparin cofactor II
    Ana M F Tovar
    Laboratório de Tecido Conjuntivo, Hospital Universitário Clementino Fraga Filho and Instituto de Bioquímica Médica, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Caixa Postal 68041, Rio de Janeiro, RJ, 21941 590, Brazil
    Biochim Biophys Acta 1740:45-53. 2005
    ..We observed that dermatan sulfate is the major anticoagulant and antithrombotic among the vessel wall glycosaminoglycans while the bulk of ..
  85. pmc Exogenous addition of a C-xylopyranoside derivative stimulates keratinocyte dermatan sulfate synthesis and promotes migration
    Jun Muto
    Division of Dermatology, University of California, San Diego and Veterans Affairs San Diego Health Care System, San Diego, California, United States of America
    PLoS ONE 6:e25480. 2011
    As C-Xyloside has been suggested to be an initiator of glycosaminoglycan (GAG) synthesis, and GAGs such as Dermatan sulfate (DS) are potent enhancers of fibroblast growth factor (FGF)--10 action, we investigated if a C-Xylopyranoside ..
  86. ncbi Molecular basis for the susceptibility of fibrin-bound thrombin to inactivation by heparin cofactor ii in the presence of dermatan sulfate but not heparin
    P C Liaw
    McMaster University and the Henderson Research Centre, Hamilton, Ontario L8V 1C3, Canada
    J Biol Chem 276:20959-65. 2001
    ..antithrombin and heparin.heparin cofactor II complexes, indirect studies in plasma systems suggest that the dermatan sulfate.heparin cofactor II complex can inhibit fibrin-bound thrombin...
  87. ncbi Validation of disaccharide compositions derived from dermatan sulfate and heparan sulfate in mucopolysaccharidoses and mucolipidoses II and III by tandem mass spectrometry
    Shunji Tomatsu
    Department of Pediatrics, Saint Louis University, St Louis, MO, United States
    Mol Genet Metab 99:124-31. 2010
    ..MPS and ML II and III patients can not properly degrade dermatan sulfate (DS) and/or heparan sulfate (HS)...
  88. ncbi The preferred pathway of glycosaminoglycan-accelerated inactivation of thrombin by heparin cofactor II
    Ingrid M Verhamme
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2561, USA
    J Biol Chem 279:9785-95. 2004
    ..T) inactivation by the serpin, heparin cofactor II (HCII), is accelerated by the glycosaminoglycans (GAGs) dermatan sulfate (DS) and heparin (H). Equilibrium binding and thrombin inactivation kinetics at pH 7...
  89. ncbi Dermatan sulfate domains defined by the novel antibody GD3A12, in normal tissues and ovarian adenocarcinomas
    Gerdy B ten Dam
    Department of Biochemistry 280, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, PO Box 9101, 6500HB Nijmegen, The Netherlands
    Histochem Cell Biol 132:117-27. 2009
    b>Dermatan sulfate (DS) expression in normal tissue and ovarian cancer was investigated using the novel, phage display-derived antibody GD3A12 that was selected against embryonic glycosaminoglycans (GAGs)...
  90. ncbi Determination of oversulfated chondroitin sulfate and dermatan sulfate impurities in heparin by capillary electrophoresis
    Govert W Somsen
    Department of Biomedical Analysis, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    J Chromatogr A 1216:4107-12. 2009
    ..the reliable quantification of OSCS in heparin samples, but also allows determination of the common impurity dermatan sulfate (DS)...
  91. ncbi Identification of chondroitin/dermatan sulfotransferases in the protochordate, Ciona intestinalis
    Akira Tetsukawa
    Department of Applied Science, Faculty of Science, Kochi University, 2 5 1 Akebono cho, Kochi shi, Kochi 780 8520, Japan
    Comp Biochem Physiol B Biochem Mol Biol 157:205-12. 2010
    ..Region-specific expression in the epidermis was also observed. The present study provides useful information for further comparative and functional analyses of sulfotransferases and proteoglycans in chordate embryos...
  92. pmc The chondroitin/dermatan sulfate synthesizing and modifying enzymes in laryngeal cancer: expressional and epigenetic studies
    Dimitrios Kalathas
    1Department of Chemistry, Laboratory of Biochemistry, Section of Organic Chemistry and Natural Products, Karatheodori str, University of Patras, Patras, 26500, Greece
    Head Neck Oncol 2:27. 2010
    ..The most characteristics are in chondroitin/dermatan sulfate fine structure and proportion, which might be due to differential expression of the enzymes involved in their ..
  93. pmc Electron detachment dissociation of dermatan sulfate oligosaccharides
    Jeremy J Wolff
    Department of Chemistry, University of Georgia, Athens, Georgia 30602, USA
    J Am Soc Mass Spectrom 19:294-304. 2008
    ..application of electron detachment dissociation (EDD) Fourier transform mass spectrometry to the analysis of dermatan sulfate (DS) oligosaccharides up to 10 residues long...
  94. ncbi Characterization of chondroitin sulfate and dermatan sulfate proteoglycans of extracellular matrices of human umbilical cord blood vessels and Wharton's jelly
    Manojkumar Valiyaveettil
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Glycoconj J 21:361-75. 2004
    The chondroitin sulfate/dermatan sulfate proteoglycans (CS/DSPGs) of the human umbilical cord vein, arteries and Wharton's jelly matrices were characterized and localized by immunohistochemical analysis...
  95. ncbi Biochemical monitoring after haemopoietic stem cell transplant for Hurler syndrome (MPSIH): implications for functional outcome after transplant in metabolic disease
    H Church
    Willink Unit for Biochemical Genetics, Department of Paediatrics, Royal Manchester Children s Hospital, Manchester, UK
    Bone Marrow Transplant 39:207-10. 2007
    ....
  96. pmc Human proteins with affinity for dermatan sulfate have the propensity to become autoantigens
    Jung Hyun Rho
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Pathol 178:2177-90. 2011
    ..and in a companion article in this issue, we show that affinity of self molecules to the glycosaminoglycan dermatan sulfate (DS) is a common property of autoantigens and leads to a specific autoreactive B-1a cell response...
  97. pmc Placental dermatan sulfate: isolation, anticoagulant activity, and association with heparin cofactor II
    Tusar K Giri
    Hematology Division, Campus Box 8125, Washington University Medical School, 660 South Euclid Ave, St Louis, MO 63110, USA
    Blood 107:2753-8. 2006
    ..b>Dermatan sulfate (DS) specifically activates HCII and is abundant in the placenta, but the locations of DS and HCII in the ..
  98. ncbi Dermatan sulfate proteoglycan and glycosaminoglycan synthesis is induced in fibroblasts by transfer to a three-dimensional extracellular environment
    Phillip H A Lee
    Division of Dermatology, University of California San Diego, 92161, USA
    J Biol Chem 279:48640-6. 2004
    ..switching NIH3T3 fibroblasts from growth on type 1 collagen in monolayer to a collagen gel might influence dermatan sulfate expression...
  99. ncbi Keratan sulfate and dermatan sulfate proteoglycans associate with type VI collagen in fetal rabbit cornea
    T Takahashi
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts
    J Histochem Cytochem 41:1447-57. 1993
    Keratan sulfate proteoglycan (KSPG) and dermatan sulfate proteoglycan (DSPG) are associated with collagen fibrils in adult rabbit cornea...
  100. ncbi Anticoagulant dermatan sulfate proteoglycan (decorin) in the term human placenta
    M A Delorme
    The Department of Medicine, University of Western Ontario, London, Canada
    Thromb Res 90:147-53. 1998
    ..cofactor II complexes suggests that the site of the additional thrombin generation is relatively rich in dermatan sulfate. We postulated that the site of thrombin generation may be the placenta since endogenous thrombin generation ..
  101. ncbi Inhibition of human dermal fibroblast proliferation by removal of dermatan sulfate
    E M Denholm
    Department of Cellular Biology, IBEX Pharmaceuticals, Inc, 5485 Pare, H4P 1P7, Montreal, Quebec, Canada
    Eur J Pharmacol 400:145-53. 2000
    In the current study, a glycosaminoglycan lyase, chondroitinase B, was used to study the role of dermatan sulfate proteoglycans on human dermal fibroblast proliferation...

Research Grants62

  1. Retroviral Vector-mediated Liver Gene Therapy for MPS I
    Katherine P Ponder; Fiscal Year: 2013
    ..a-L-iduronidase (IDUA) activity, which results in the accumulation of the glycosaminoglycans heparan and dermatan sulfate. The severe form, known as Hurler syndrome, causes bone and joint abnormalities, pulmonary and cardiac ..
  2. STRUCTURE AND FUNCTION OF HEPARIN COFACTOR II
    Douglas M Tollefsen; Fiscal Year: 2010
    Heparin cofactor II (HCII) is an inhibitor of thrombin in plasma that can be activated by dermatan sulfate (DS) proteoglycans on vascular smooth muscle cells and fibroblasts...
  3. The role of Histidine rich protein II in cerebral malaria
    Priya Pal; Fiscal Year: 2013
    ..laboratory show that HRPII binds to soluble glycosaminoglycans (GAGs) such as heparin, heparan sulfate, and dermatan sulfate with high affinity...
  4. A collagen wound dressing augmented with a proteoglycan mimic to enhance chronic
    Kate Stuart; Fiscal Year: 2013
    ..The molecule, inspired by the native proteoglycan decorin, is composed of a dermatan sulfate (DS) backbone with attached collagen binding peptides (SILY)...
  5. Improved Therapeutics for Drug Eluting Stents
    Alyssa Panitch; Fiscal Year: 2013
    ..couple release of this drug from a DES with a temporary monolayer coating of blood vessel with peptidoglycan (dermatan sulfate (DS)) conjugated with collagen-binding eicosapeptide, RRANAALKAGELYKSILYGC (abbreviated SILY)) that prevents ..
  6. GENETIC MODULATION OF BLOOD AND VASCULAR GLYCOSYLATION
    NISSI MARY VARKI; Fiscal Year: 2012
    ..Sias) and the Glycosaminoglycan (GAG) chains Hyaluronan (HA), Heparan sulfate (HS) and Chondrotin suflate/Dermatan sulfate (CS/DS)...
  7. Newborn Screening and Biomarkers for Mucopolysaccharidoses
    Shunji Tomatsu; Fiscal Year: 2013
    ..methods for MPS are designed to measure urinary total GAGs (heparan sulfate: HS, keratan sulfate: KS, dermatan sulfate: DS, chondroitin sulfate: CS) and cannot be applied to NBS blood samples...
  8. Glycan Modulation of Inflammatory Responses
    Ajit P Varki; Fiscal Year: 2013
    ..acids (Sias) and the glycosaminoglycans (GAGs), hyaluronan (HA), heparan sulfate (HS) and chondroitin sulfate/dermatan sulfate (CS/DS)...
  9. Autoantibodies Against Thrombin in Lupus Atherosclerosis
    MAUREEN A MCMAHON; Fiscal Year: 2010
    ..Of note, inactivation of thrombin by HCII is enhanced by more than 1,000-fold after binding to dermatan sulfate (DS), which is the predominant antithrombotic glycosaminoglycan in arterial walls...
  10. BIOSYNTHESIS OF COMPLEX CARBOHYDRATES IN BRAIN
    LENNART RODEN; Fiscal Year: 1993
    ..the first category include two serine-linked pentasaccharides from the linkage regions of chondroitin sulfate/dermatan sulfate and heparin/heparan sulfate, respectively...
  11. MUCOPOLYSACCHARIDOSES AND CATHEPSIN K
    Dieter Bromme; Fiscal Year: 2007
    ..Depending on the enzyme deficiency, affected cells accumulate dermatan sulfate, heparan sulfate, chondroitin sulfate, keratan sulfate or combinations thereof and the clinical phenotype ..
  12. MOLECULAR STUDIES OF CORNEAL TRANSPARENCY
    John Hassell; Fiscal Year: 2003
    ..primarily of collagens I, V, & VI and of proteoglycans bearing keratan sulfate (KS) and chondroitin/dermatan sulfate side chains...
  13. Substrate Reduction Therapy Strategies for Treatment of Mucopolysaccharidoses
    William C Lamanna; Fiscal Year: 2012
    ..which heparan sulfate storage in MPSIIIa cells results in the dramatic secondary accumulation of chondoitin/dermatan sulfate. In the first aim of this project we will further characterize the secondary storage of chondroitin/dermatan ..
  14. CARBOHYDRATE-CONTAINING MACROMOLECULES IN AGING BRAIN
    ERIC BRUNNGRABER; Fiscal Year: 1980
    ..choloride and analyzed to distinguish between the levels of chondroitin 4- and 5-sulfate, heparan sulfate, dermatan sulfate, hyaluronic acid and chondroitin...
  15. Antithrombotic Activity of Ascidian Glycosaminoglycans
    DOUGLAS TOLLEFSEN; Fiscal Year: 2004
    ..b>Dermatan sulfate is a related polymer that specifically activates HCII...
  16. GLUCOSAMINE IN CARTILAGE HOMEOSTASIS AND DEGRADATION
    ALEXANDER SHIKHMAN; Fiscal Year: 2004
    ..on production of glycosaminoglycans, including hyaluronic acid, chondroitin-6 sulfate, chondroitin-4 sulfate, dermatan sulfate, and keratan sulfate, in cultured human chondrocytes isolated from normal and osteoarthritic joints; 2) to ..
  17. DbpA/B proteins of Borrelia burgdorferi & Lyme arthritis
    Nikhat Parveen; Fiscal Year: 2005
    ..Decorin binding lipoproteins DbpA and DbpB of B. burgdorferi show affinity for heparin and dermatan sulfate GAGs in addition to the proteoglycan decorin...
  18. FIBRONECTIN--PROTEOGLYCAN BINDING IN ADHESION SITES
    LLOYD CULP; Fiscal Year: 1993
    ..to the tumor-progressing phenotype and/or the state of the oncogene. We will also test whether dermatan sulfate PG inhibits attachment or facilitates detachment of tumor cells on FN more or less effectively than 3T3 cells ..
  19. Electrochemically Guided Collagen Synthesis for Functional Tissue Engineering
    Ozan Akkus; Fiscal Year: 2009
    ..The viscoelastic properties of oriented constructs will be modified by decorin mimics consisting of dermatan sulfate attached to peptide motifs which selectively bind to type I collagen molecules...
  20. HYALURONAN MATRIX ASSEMBLY IN CUMULUS-OOPHORUS EXPANSION
    Vincent Hascall; Fiscal Year: 2000
    ..We have also shown that the cells synthesize a large chondroitin/dermatan sulfate proteoglycan and approximately 45 kDa protein that are incorporated into the matrix during COC expansion...
  21. Dermatan sulfate and its role in tissue repair
    Katherine Radek; Fiscal Year: 2009
    GAGs have emerged as critical signaling molecules in an array of cell signaling events. Although dermatan sulfate (DS) is the most abundant GAG in the skin and in wound fluid, this represents an area of wound healing which remains to be ..
  22. PROTEOGLYCANS OF ORAL TISSUES
    Firoz Rahemtulla; Fiscal Year: 1990
    ..Monoclonal and polyclonal antibodies will be prepared against dermatan sulfate proteoglycans of soft connective tissues and heparan sulfate proteoglycans synthesized by keratinocytes...
  23. PROTEOGLYCANS WOUND REPAIR AND INFLAMMATION
    Richard Gallo; Fiscal Year: 2005
    ..In addition wound derived GAGs, namely, dermatan sulfate, are responsible for activation of the growth factor FGF-2...
  24. DERMATAN SULFATE CATABOLISM
    Arvan Fluharty; Fiscal Year: 1980
    ..characterize the degradative pathway of the glycosaminoglucuronoglycan (acid mucopolysaccharide), dermatan sulfate. Mixed mucopolysaccharides labeled biosynthetically with a radioactive tracer are treated with a series of ..
  25. Heparin Cofactor II Activation Mechanism
    Miriam Foshay; Fiscal Year: 2004
    ..Heparin and dermatan sulfate accelerate its rate of inhibition 10[3] to 10[4]-fold through an allosteric mechanism that is only partly ..
  26. REGULATION OF DERMATAN SULFATE FORMATION BY CHONDROCYTES
    Robert Kokenyesi; Fiscal Year: 1999
    ..The distinctive functions of dermatan sulfate proteoglycans in regulation of collagen fibrillogenesis, compared with that for space filling and water ..
  27. Clinically relevant large animal model of rotator cuff injury and repair
    Kathleen Derwin; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  28. A role for intrinsic tendon cells in overuse injury
    Kathleen Derwin; Fiscal Year: 2005
    ..A role for intrinsic tendon cells in the pathogenesis of tendon overuse injury would be implied by a lower damage threshold in vital tendon. ..
  29. Bioreactor Organ Cultures of Serotonergic Valvulopathies
    KATHRYN GRANDE ALLEN; Fiscal Year: 2007
    ..In the future, similar methods can be used to screen potentially damaging drugs and to understand other valve diseases - both essential to public health. [unreadable] [unreadable]..
  30. Fibronectin peptides for treatment of burns
    Richard Clark; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  31. Bioactive signal gradients to engineer TMJ condyle osteochondral constructs
    MICHAEL DETAMORE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  32. SERPIN-PROTEASE REACTION, HYDRATION AND GEOMETRY CHANGES
    Maria McGee; Fiscal Year: 2002
    ..This information will serve to develop therapies to prevent and control thromboembolic complications of cardiovascular disease. ..
  33. EUKARYOTIC HYALURONAN SYNTHASES
    PAUL DEANGELIS; Fiscal Year: 2001
    ..The essential residues identified in aim 3 will also be confirmed by mutagenesis studies. The enzymological and structural information may allow the generation of a working model describing the catalytic mechanism of these enzymes. ..
  34. Mechanisms of Hemostatic Protease Inhibition by Serpins
    Ingrid M Verhamme; Fiscal Year: 2010
    ..Thrombin localized on fibrin (Fbn) and the glycosaminoglycans (GAGs) dermatan sulfate (DS)and heparin, reacts with HCII and platelet PAI-1, in GAG-accelerated mechanisms different from thrombin ..
  35. ENZYMATIC DEGRADATION OF GLYCOSAMINOGLYCANS
    Ram Sasisekharan; Fiscal Year: 2010
    ..We believe that our study would truly accelerate the progress of understanding GAG-structure-function relationships in fundamental biological processes-a research area that is gaining increasing importance. ..
  36. A Thermo Electron LTQ Mass Spectrometer
    Joseph Zaia; Fiscal Year: 2006
    ..The salary for the instrument operator will be provided by the Dean of BU School of Medicine. [unreadable] [unreadable]..
  37. DERIVATIZED HYALURONAN FOR WOUND HEALING
    Richard Clark; Fiscal Year: 2001
    ..Finally it will be determined whether hyaluronan constructs that are optimal in vitro for cell migration are also optimal in vivo for cutaneous wound healing. ..
  38. Structure-Activity Relationships of LMWHs
    Ram Sasisekharan; Fiscal Year: 2008
    ..anti-Xa and anti-IIa and their pharmacokinetic in vivo elimination ..
  39. Functional Roles of Cell Phenotypes in Myxomatous Mitral Valve Disease
    KATHRYN GRANDE ALLEN; Fiscal Year: 2007
    ..To understand why the valve changes, we plan to grow cells from mitral valves in an incubator and use stretching conditions to mimic the circumstances of the disease. [unreadable] [unreadable] [unreadable]..
  40. Tissue Engineering Analysis of PG-Dependent Biomechanics
    KATHRYN GRANDE ALLEN; Fiscal Year: 2007
    ..This basic research will improve our understanding of biomechanics, development, and the growth of replacement tissues. [unreadable] [unreadable] [unreadable]..
  41. Hyperglycemia, Aldose Reducatse & Murine Atherosclerosis
    Ira Goldberg; Fiscal Year: 2005
    ..This is significant because it will provide for a model to study this complication and suggest a therapeutic target for prevention of diabetic macrovascular disease. ..
  42. OPTIMIZING MANAGEMENT OF TRANSIENT ISCHEMIC ATTACKS
    S Johnston; Fiscal Year: 2005
    ..This research will provide important results for clinicians and policy makers, and will foster the applicant's development as a health services researcher in cerebrovascular disease. ..
  43. FMRI in Pre-Symptomatic PS1-related Alzheimer's Disease
    John Ringman; Fiscal Year: 2005
    ..UCI, with its strong dementia research program, growing MRI capabilities and opportunity to collaborate at the nearby UCLA Brain Imaging Center, is an excellent environment for this endeavor. ..
  44. Treatment of Hyperglycemia Ischemic Stroke(THIS)Trial
    Askiel Bruno; Fiscal Year: 2004
    ..Additional measurements will include vital signs, serum electrolytes, hemoglobin A-1C, and a global test for multiple clinical outcomes at 3 months. ..
  45. Collagen-binding proteins in softening of uterine cervix
    Robert Kokenyesi; Fiscal Year: 2003
    ....
  46. MIDCAREER INVESTIGATOR AWARD IN CEREBROVASCULAR RESEARCH
    Larry Goldstein; Fiscal Year: 2004
    ....
  47. Heparin like Glycosaminoglycan Oligosaccharides
    Ram Sasisekharan; Fiscal Year: 2004
    ..Similar technologies for DNA and proteins include things like gene chips that have revolutionized the study of these molecules. We hope advancements, like out technology, will do the same thing for HLGAGs. ..
  48. Database for Glycan Structures
    Ram Sasisekharan; Fiscal Year: 2005
    ..This forms the framework for the present STTR grant application as a fast-track Phases I and II grant application that is highly integrated towards addressing the requirements of the glycomics field. ..
  49. Correction of neural abnormalities in Hurler syndrome
    Pankaj Gupta; Fiscal Year: 2003
    ....
  50. Correction of Hurler syndrome by multipotent stem cells
    Pankaj Gupta; Fiscal Year: 2007
    ..If MAPC transplantation is of benefit in the Hurler model, similar strategies may be developed for treating diverse neurodegenerative disorders. ..
  51. Oligosaccharides Regulating Cell Function
    Ram Sasisekharan; Fiscal Year: 2006
    ..This grant application represents a high risk/high reward undertaking aimed at developing LMP as an effective treatment for of debilitating diseases caused by the deregulation of apoptosis, such as cancer. [unreadable] [unreadable]..
  52. Glycosaminoglycan-Protein Binding
    Joseph Zaia; Fiscal Year: 2006
    ..abstract_text> ..
  53. AMPHETAMINE ENHANCED STROKE RECOVERY--BURKE SRCI GROUP
    Larry Goldstein; Fiscal Year: 2002
    ..However the treatment duration will be increased to a total of 10 sessions. ..
  54. Failure of Axon Repair in Chronic MS Lesions
    Raymond Sobel; Fiscal Year: 2006
    ..Moreover, they will be important for understanding results of stem cell-based therapies of MS lesions which require recapitulation of developmental processes that are dependent on the CNS ECM and eph/Eph signaling. ..
  55. TMJ Bioengineering Conference
    MICHAEL DETAMORE; Fiscal Year: 2006
    ..abstract_text> ..
  56. Consensus Conference Grant
    Kathryn Hassell; Fiscal Year: 2006
    ..abstract_text> ..
  57. Molecular Principles of FGF-HSGAG Interactions
    Ram Sasisekharan; Fiscal Year: 2006
    ..abstract_text> ..
  58. ATHEROGENICITY OF APOB CONTAINING LIPOPROTEINS
    Ira Goldberg; Fiscal Year: 2003
    ..Moreover, the experiments are significant for our understanding of atherosclerosis development and may demonstrate molecular methods to alter apoB retention that could be used in treatment and preventative therapies. ..