chondroitin sulfates

Summary

Summary: Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate.

Top Publications

  1. pmc Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling
    Yasunori Shintani
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    EMBO J 25:3045-55. 2006
  2. ncbi Expression of multiple chondroitin/dermatan sulfotransferases in the neurogenic regions of the embryonic and adult central nervous system implies that complex chondroitin sulfates have a role in neural stem cell maintenance
    Kaoru Akita
    Department of Cell Morphology and Molecular Neurobiology, Faculty of Biology, Ruhr University Bochum, NDEF 05 594, Universitatsstrasse 150, D 44780 Bochum, Germany
    Stem Cells 26:798-809. 2008
  3. ncbi The structure of glycosaminoglycans and their interactions with proteins
    Neha S Gandhi
    Western Australian Biomedical Research Institute, Curtin University of Technology, Perth, WA 6845, Australia
    Chem Biol Drug Des 72:455-82. 2008
  4. ncbi Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis
    Michael Klüppel
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Development 132:3989-4003. 2005
  5. pmc Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA
    Anand Srivastava
    Institut Pasteur, Unité de Biologie des Interactions Hôte Parasite, Centre National de la Recherche Scientifique Unité de Recherche Associée 2581, 25 rue du Docteur Roux, F 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 107:4884-9. 2010
  6. pmc Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies
    Pongsak Khunrae
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    J Mol Biol 397:826-34. 2010
  7. ncbi Specific molecular interactions of oversulfated chondroitin sulfate E with various heparin-binding growth factors. Implications as a physiological binding partner in the brain and other tissues
    Sarama Sathyaseelan Deepa
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Japan
    J Biol Chem 277:43707-16. 2002
  8. ncbi Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta
    M Fried
    U S Army Medical Research Unit Kenya, Kisumu
    Science 272:1502-4. 1996
  9. pmc Plasmodium falciparum isolates from infected pregnant women and children are associated with distinct adhesive and antigenic properties
    J G Beeson
    The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria, Australia
    J Infect Dis 180:464-72. 1999
  10. ncbi VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum
    Michael F Duffy
    The Department of Medicine, The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Mol Biochem Parasitol 148:117-24. 2006

Detail Information

Publications329 found, 100 shown here

  1. pmc Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling
    Yasunori Shintani
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    EMBO J 25:3045-55. 2006
    ..These findings indicate that GAG modification of NRP1 plays a critical role in modulating VEGF signaling, and may provide new insights into physiological and pathological angiogenesis...
  2. ncbi Expression of multiple chondroitin/dermatan sulfotransferases in the neurogenic regions of the embryonic and adult central nervous system implies that complex chondroitin sulfates have a role in neural stem cell maintenance
    Kaoru Akita
    Department of Cell Morphology and Molecular Neurobiology, Faculty of Biology, Ruhr University Bochum, NDEF 05 594, Universitatsstrasse 150, D 44780 Bochum, Germany
    Stem Cells 26:798-809. 2008
    ..The synergistic activities of C/D-STs might allow for the adaptive modification of CS/DS proteoglycans with diversely sulfated CS/DS chains in the extracellular microenvironment that surrounds neural stem cells...
  3. ncbi The structure of glycosaminoglycans and their interactions with proteins
    Neha S Gandhi
    Western Australian Biomedical Research Institute, Curtin University of Technology, Perth, WA 6845, Australia
    Chem Biol Drug Des 72:455-82. 2008
    ..New approaches to the development of GAG mimetics as possible new glycotherapeutics are also briefly covered...
  4. ncbi Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis
    Michael Klüppel
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Development 132:3989-4003. 2005
    ..Our study demonstrates an important biological role of differential chondroitin sulfation in mammalian development...
  5. pmc Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA
    Anand Srivastava
    Institut Pasteur, Unité de Biologie des Interactions Hôte Parasite, Centre National de la Recherche Scientifique Unité de Recherche Associée 2581, 25 rue du Docteur Roux, F 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 107:4884-9. 2010
    ..These results have important consequences for the development of an effective vaccine and therapeutic inhibitors...
  6. pmc Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies
    Pongsak Khunrae
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    J Mol Biol 397:826-34. 2010
    ..The specificity of the binding and anti-adhesion potency of induced IgG, together with high-yield production, encourages the use of full-length PfEMP1 in vaccine development strategies...
  7. ncbi Specific molecular interactions of oversulfated chondroitin sulfate E with various heparin-binding growth factors. Implications as a physiological binding partner in the brain and other tissues
    Sarama Sathyaseelan Deepa
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Japan
    J Biol Chem 277:43707-16. 2002
    ..These findings suggest the possibility of CS-E being a binding partner, a coreceptor, or a genuine receptor for various Hep-binding growth factors in the brain and possibly also in other tissues...
  8. ncbi Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta
    M Fried
    U S Army Medical Research Unit Kenya, Kisumu
    Science 272:1502-4. 1996
    ..Thus, adhesion to CSA appears to select for a subpopulation of parasites that causes maternal malaria...
  9. pmc Plasmodium falciparum isolates from infected pregnant women and children are associated with distinct adhesive and antigenic properties
    J G Beeson
    The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria, Australia
    J Infect Dis 180:464-72. 1999
    ..The prevalence of agglutinating antibodies to pregnancy isolates was generally low, but it was highest in multigravidae who are likely to have had the greatest exposure...
  10. ncbi VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum
    Michael F Duffy
    The Department of Medicine, The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Mol Biochem Parasitol 148:117-24. 2006
    ....
  11. pmc Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development
    Yumi Watanabe
    Niigata University, Chuo Ku, Japan
    Biochem J 432:47-55. 2010
    ..Additionally, type-II collagen fibres in developing cartilage were abnormally aggregated and disarranged in the homozygous mutant mice. These results suggest that CSGalNAcT1 is required for normal CS production in developing cartilage...
  12. pmc Mice deficient in N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase are unable to synthesize chondroitin/dermatan sulfate containing N-acetylgalactosamine 4,6-bissulfate residues and exhibit decreased protease activity in bone marrow-derived mast cells
    Shiori Ohtake-Niimi
    Department of Chemistry, Aichi University of Education, Igaya cho, Kariya, Aichi 448 8542, Japan
    J Biol Chem 285:20793-805. 2010
    ..These observations suggest that CS containing GalNAc(4,6-SO(4)) residues in BMMCs may contribute to retain the active proteases in the granules of BMMCs but not for the maturation of BMMCs into connective tissue-type mast cells...
  13. ncbi Sulfation pattern of the fucose branch is important for the anticoagulant and antithrombotic activities of fucosylated chondroitin sulfates
    Shiguo Chen
    College of Biosystem Engineering and Food Science, Zhejiang University, Hangzhou 310029, China
    Biochim Biophys Acta 1830:3054-66. 2013
    The aim is to compare the structures, anticoagulant and antithrombotic activities of two fucosylated chondroitin sulfates isolated from sea cucumbers Isostichopus badionotus (fCS-Ib) and Pearsonothuria graeffei (fCS-Pg), which were known ..
  14. ncbi Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria
    Ali Salanti
    Centre for Medical Parasitology at the Institute for Medical Microbiology and Immunology, University of Copenhagen, Panum Institute 24 2, and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Denmark
    Mol Microbiol 49:179-91. 2003
    ..falciparum malaria. This var gene thus has the properties expected of a gene encoding the parasite adhesion molecule that initiates the pathology associated with PAM...
  15. ncbi Oversulfated chondroitin/dermatan sulfates containing GlcAbeta1/IdoAalpha1-3GalNAc(4,6-O-disulfate) interact with L- and P-selectin and chemokines
    Hiroto Kawashima
    Laboratory of Molecular and Cellular Recognition, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Japan
    J Biol Chem 277:12921-30. 2002
    ....
  16. pmc PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration
    Yingjie Shen
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Science 326:592-6. 2009
    ..These results indicate that PTPsigma can act as a receptor for CSPGs and may provide new therapeutic approaches to neural regeneration...
  17. ncbi N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice show better functional recovery after spinal cord injury
    Zenya Ito
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Neurosci 30:5937-47. 2010
    ..N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice are a good model to investigate the roles of keratan sulfate in the CNS...
  18. ncbi Chondroitin sulphate A (CSA)-binding of single recombinant Duffy-binding-like domains is not restricted to Plasmodium falciparum Erythrocyte Membrane Protein 1 expressed by CSA-binding parasites
    Mafalda Resende
    Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, CSS, Øster Farimagsgade 5 A, DK 1014 Copenhagen K, Denmark
    Int J Parasitol 39:1195-204. 2009
    ..The data suggest that the ability of single domains to bind CSA does not predict the functional capacity of the whole PfEMP1 and raises doubt whether the CSA-binding domains of native VAR2CSA have been correctly identified...
  19. ncbi Chondroitin sulfate and keratan sulfate are the major glycosaminoglycans present in the adult zebrafish Danio rerio (Chordata-Cyprinidae)
    Aline R C Souza
    Laboratório de Tecido Conjuntivo, Hospital Universitário Clementino Fraga Filho and Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Caixa Postal 68041, Rio de Janeiro, RJ, CEP 21941 590, Brazil
    Glycoconj J 24:521-30. 2007
    ..Detailed information about the structure and tissue localization of GAGs is important to understand the functions of these polymers in this model organism...
  20. ncbi Antiviral activity of chondroitin sulphate E targeting dengue virus envelope protein
    Daisuke Kato
    Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, and Global COE Program for Innovation in Human Health Sciences, 52 1 Yada, Suruga ku, Shizuoka shi, Shizuoka 422 8526, Japan
    Antiviral Res 88:236-43. 2010
    ..In conclusion, CSE showed antiviral activity as an entry inhibitor targeting E protein of dengue virus...
  21. ncbi Sulfation of chondroitin sulfate in human articular cartilage. The effect of age, topographical position, and zone of cartilage on tissue composition
    M T Bayliss
    Royal Veterinary College, Royal College Street, London NW1 OTU, United Kingdom
    J Biol Chem 274:15892-900. 1999
    ..Furthermore, these changes in composition are a consequence of both extracellular, post-translational processing of the core protein of aggrecan and changes in the sulfotransferase activity of the chondrocyte...
  22. pmc Nanoscale modification of porous gelatin scaffolds with chondroitin sulfate for corneal stromal tissue engineering
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, Republic of China
    Int J Nanomedicine 7:1101-14. 2012
    ..Porous membranes with a CS content of 0.112 ± 0.003 nmol per 10 mg scaffold may hold potential for use in corneal stromal tissue engineering...
  23. pmc Chondroitin-4-sulfation negatively regulates axonal guidance and growth
    Hang Wang
    Developmental Neurobiology Section, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 121:3083-91. 2008
    ..Thus, our findings show that specific sulfation along the carbohydrate backbone carries instructions to regulate neuronal function...
  24. pmc Chondroitin sulfate "wobble motifs" modulate maintenance and differentiation of neural stem cells and their progeny
    Anurag Purushothaman
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 287:2935-42. 2012
    ....
  25. pmc Evidence for the involvement of VAR2CSA in pregnancy-associated malaria
    Ali Salanti
    Centre for Medical Parasitology, Dept of Medical Microbiology and Immunology, Panum Institute 24 2, Blegdamsvej 3, 2200 Copenhagen, Denmark
    J Exp Med 200:1197-203. 2004
    ....
  26. ncbi Effects of oversulfated and fucosylated chondroitin sulfates on coagulation. Challenges for the study of anticoagulant polysaccharides
    Roberto J C Fonseca
    Laboratório de Tecido Conjuntivo, Hospital Universitário Clementino Fraga Filho and Programa de Glicobiologia, Instituto de Bioquimica Medica, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Thromb Haemost 103:994-1004. 2010
    ..These highly sulfated chondroitin sulfates activate factor XII in in vitro assays, based on kallikrein release...
  27. ncbi Specific interactions between human fibroblasts and particular chondroitin sulfate molecules for wound healing
    Xiao Hui Zou
    Women s Hospital, School of Medicine, Zhejiang University, China
    Acta Biomater 5:1588-95. 2009
    The chondroitin sulfates (CSs) constitute an important group of biomacromolecules in the extracellular matrix. However, limited information is available about their specific biological functions...
  28. ncbi Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence
    Tomoyuki Kaneiwa
    Laboratory of Proteoglycan Signaling and Therapeutics, Hokkaido University Graduate School of Life Science, Sapporo, Japan
    Glycobiology 20:300-9. 2010
    ..In addition, it may well be applicable to the treatment of acute spinal cord injuries as in the case of, or instead of, the bacterial CS lyase which has been used for recent clinical trials...
  29. pmc Fucosylated chondroitin sulfate inhibits plasma thrombin generation via targeting of the factor IXa heparin-binding exosite
    Yang Buyue
    Department of Medicine Hematology Oncology, University of Wisconsin Madison, Madison, WI 53706, USA
    Blood 114:3092-100. 2009
    ..Glycosaminoglycan-mediated intrinsic tenase inhibition is a novel antithrombotic mechanism with physiologic and therapeutic applications...
  30. pmc Contaminated heparin associated with adverse clinical events and activation of the contact system
    Takashi Kei Kishimoto
    Momenta Pharmaceuticals, the Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA
    N Engl J Med 358:2457-67. 2008
    ....
  31. ncbi Compositional and structural alterations of chondroitin and dermatan sulfates during the progression of atherosclerosis and aneurysmal dilatation of the human abdominal aorta
    Achilleas D Theocharis
    Laboratory of Biochemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Department of Chemistry, University of Patras, 26110 Patras, Greece
    Biochimie 84:667-74. 2002
    ....
  32. pmc Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11 gene expression in forming surface P-selectin ligands in aggressive breast cancer cells
    Craig A Cooney
    Department of Biochemistry and Molecular Biology, The University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Breast Cancer Res 13:R58. 2011
    ....
  33. pmc Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A
    Kavita Singh
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA
    Nat Struct Mol Biol 15:932-8. 2008
    ..The location of the CSA binding site is an important step forward in the molecular understanding of pregnancy-associated malaria and offers a new target for vaccine development...
  34. ncbi Immunomodulatory and anti-inflammatory effects of chondroitin sulphate
    Patrick du Souich
    Department of Pharmacology, Faculty of Medicine, University of Montreal, Quebec, Canada
    J Cell Mol Med 13:1451-63. 2009
    ....
  35. pmc Expression of genes encoding for proteins involved in heparan sulphate and chondroitin sulphate chain synthesis and modification in normal and malignant plasma cells
    Caroline Bret
    INSERM U847, Equipe Labellisée LIGUE 2006, Universite Montpellier, UFR Méldecine, Montpellier, France
    Br J Haematol 145:350-68. 2009
    ..This study provides an overall picture of the major genes encoding for proteins involved in heparan sulphate and chondroitin sulphate synthesis and modifications that can be implicated in normal and malignant plasma cells...
  36. pmc Strain-transcendent immune response to recombinant Var2CSA DBL5-ε domain block P. falciparum adhesion to placenta-derived BeWo cells under flow conditions
    Pablo Fernandez
    Unité de Biologie des Interactions Hôte Parasite, Institut Pasteur, Paris, France
    PLoS ONE 5:e12558. 2010
    ..The identification of var2CSA regions that could elicit broadly neutralizing and adhesion-blocking antibodies is a key step for the design of prophylactic vaccine strategies...
  37. ncbi Biosynthesis of chondroitin/dermatan sulfate
    Jeremiah E Silbert
    Department of Veterans Affairs Medical Center, Bedford, Massachusetts 01730, USA
    IUBMB Life 54:177-86. 2002
    ..All the enzymes in the pathway for synthesis have been cloned, with the exception of the glucuronyl to iduronyl epimerase involved in the formation of dermatan residues...
  38. pmc The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains
    Madeleine Dahlbäck
    Department of International Health, Immunology, University of Copenhagen and the Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen K, Denmark
    J Biol Chem 286:15908-17. 2011
    ..Furthermore, recombinant VAR2CSA subfragments containing this region elicit antibodies with high parasite adhesion blocking activity in animal immunization experiments...
  39. ncbi Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants
    Lea Barfod
    Centre for Medical Parasitology, Department of International Health, Immunology, and Microbiology, University of Copenhagen, Denmark
    J Immunol 185:7553-61. 2010
    ..We conclude that functionally important Ab epitopes are shared by the majority of polymorphic VAR2CSA variants, which supports the feasibility of VAR2CSA-based vaccines against placental malaria...
  40. pmc The primary structure of NG2, a novel membrane-spanning proteoglycan
    A Nishiyama
    La Jolla Cancer Research Foundation, California 92037
    J Cell Biol 114:359-71. 1991
    ..The sequence of NG2 does not show significant homology with any other known proteins, suggesting that NG2 is a novel species of integral membrane proteoglycan...
  41. ncbi Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate
    Takashi Sato
    Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology AIST, Open Space Laboratory C 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    J Biol Chem 278:3063-71. 2003
    ..Quantitative real-time PCR analysis revealed that CSGalNAcT-2 transcripts were highly expressed in the small intestine, leukocytes, and spleen, however, both CSGalNAcTs were ubiquitously expressed in various tissues...
  42. pmc Involvement of highly sulfated chondroitin sulfate in the metastasis of the Lewis lung carcinoma cells
    Fuchuan Li
    Graduate School of Life Science, Hokkaido University, Sapporo 001 0021, Japan
    J Biol Chem 283:34294-304. 2008
    ..These results suggest that the E-unit-containing epitopes are involved in the metastatic process and a potential target for the diagnosis and treatment of malignant tumors...
  43. pmc Cell surface chondroitin sulfate glycosaminoglycan in melanoma: role in the activation of pro-MMP-2 (pro-gelatinase A)
    Joji Iida
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Biochem J 403:553-63. 2007
    ..These results suggest that C4S, which is expressed on tumour cell surface, can function to bind to pro-MMP-2 and facilitate its activation by MT3-MMP-expressing tumour cells to enhance invasion and metastasis...
  44. ncbi Sulfation patterns of glycosaminoglycans encode molecular recognition and activity
    Cristal I Gama
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Nat Chem Biol 2:467-73. 2006
    ....
  45. ncbi Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization
    Hiroshi Kitagawa
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 278:23666-71. 2003
    ..Thus, the ChPF is required for chondroitin polymerizing activity of mammalian ChSy...
  46. ncbi Chondroitin/dermatan sulfate in the central nervous system
    Kazuyuki Sugahara
    Frontier Research Center for Post Genomic Science and Technology, Hokkaido University Graduate School of Life Science, Kita ku, Sapporo, Hokkaido 001 0021, Japan
    Curr Opin Struct Biol 17:536-45. 2007
    ....
  47. pmc Antibody GD3G7 selected against embryonic glycosaminoglycans defines chondroitin sulfate-E domains highly up-regulated in ovarian cancer and involved in vascular endothelial growth factor binding
    Gerdy B ten Dam
    Department of Biochemistry 280, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Pathol 171:1324-33. 2007
    ..In conclusion, antibody GD3G7 identified rare CS-E-like structures that were strongly expressed in ovarian adenocarcinomas. This antibody might therefore be instrumental for identifying tumor-related CS alterations...
  48. ncbi A simplified and sensitive fluorescent method for disaccharide analysis of both heparan sulfate and chondroitin/dermatan sulfates from biological samples
    Jon A Deakin
    Cancer Research UK Glyco Oncology Group, School of Cancer and Imaging Sciences, University of Manchester, Paterson Institute for Cancer Research, Manchester M20 4BX, UK
    Glycobiology 18:483-91. 2008
    ..This simplified method should find a widespread utility for analyzing glycosaminoglycans from limited animal and cell culture samples...
  49. ncbi Binding of a large chondroitin sulfate/dermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44
    H Kawashima
    Department of Bioregulation, Biomedical Research Center, Osaka University Graduate School of Medicine 2 2, Yamada oka, Suita 565 0871, Japan
    J Biol Chem 275:35448-56. 2000
    ..Thus, proteoglycans sufficiently modified with the appropriate glycosaminoglycans should be able to bind L-selectin, P-selectin, and/or CD44...
  50. ncbi Biochemical basis of the pharmacologic action of chondroitin sulfates on the osteoarticular system
    J P Bali
    Faculty of Pharmacy, University Montpellier I, France
    Semin Arthritis Rheum 31:58-68. 2001
    b>Chondroitin sulfates (CS) are involved in articular metabolism and could be used as therapeutic agents in degenerative articular diseases.
  51. ncbi Anti-inflammatory activity of chondroitin sulfate
    M Iovu
    Department of Pharmacology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada
    Osteoarthritis Cartilage 16:S14-8. 2008
    ..This review discusses the evidence supporting that CS pleiotropic effects in chondrocytes and synoviocytes are primarily due to a common mechanism, e.g., the inhibition of NF-kappaB nuclear translocation...
  52. ncbi Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human
    Shuichi Hiraoka
    Laboratory for Developmental Genetics, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehirocho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Nat Med 13:1363-7. 2007
    ..Our findings highlight the crucial role of NSTs in proteoglycan function and cartilage metabolism, thus revealing a new paradigm for skeletal disease and glycobiology...
  53. ncbi Receptor-binding residues lie in central regions of Duffy-binding-like domains involved in red cell invasion and cytoadherence by malaria parasites
    Alfredo Mayor
    Malaria Group, International Centre for Genetic Engineering and Biotechnology ICGEB, PO Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    Blood 105:2557-63. 2005
    ..Determination of functional regions within DBL domains is the first step toward understanding the structure-function bases for their interaction with diverse host receptors...
  54. pmc Identification and molecular analysis of glycosaminoglycans in cutaneous lupus erythematosus and dermatomyositis
    Laura M Chang
    Philadelphia VA Medical Center, Philadelphia, Pennsylvania, USA
    J Histochem Cytochem 59:336-45. 2011
    ..Based on their known immunomodulatory effects in other systems, HA and CS may thus participate in the pathophysiology of these inflammatory skin conditions...
  55. ncbi Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: a randomized, controlled trial
    Beat A Michel
    University Hospital Zurich, Zurich, Switzerland
    Arthritis Rheum 52:779-86. 2005
    ..To determine whether chondroitin sulfate (CS) is effective in inhibiting cartilage loss in knee osteoarthritis (OA)...
  56. ncbi Involvement of chondroitin sulfate E in the liver tumor focal formation of murine osteosarcoma cells
    - Basappa
    Graduate School of Life Science, Hokkaido University, Sapporo, Japan
    Glycobiology 19:735-42. 2009
    ..Thus, the present study reveals the significance of highly sulfated CS/DS structures in the liver colonization of osteosarcoma cells and also provides a framework for the development of GAG-based anticancer molecules...
  57. ncbi Chondroitinase ABC promotes compensatory sprouting of the intact corticospinal tract and recovery of forelimb function following unilateral pyramidotomy in adult mice
    Michelle L Starkey
    Regeneration Group, King s College London, Wolfson Centre for Age Related Diseases, Hodgkin Building, Guy s Campus, London Bridge, London, SE1 IUL, UK
    Eur J Neurosci 36:3665-78. 2012
    ..Enhancing compensatory sprouting using ChABC provides a route to restore function that could be applied to disorders such as spinal cord injury and stroke...
  58. pmc Inhibition of chondroitin-4-sulfate-specific adhesion of Plasmodium falciparum-infected erythrocytes by sulfated polysaccharides
    Katherine T Andrews
    The Australian Centre for International and Tropical Health and Nutrition, Infectious Diseases and Immunology Division, Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Australia
    Infect Immun 73:4288-94. 2005
    ..Therefore, the specific anti-adhesive capacity observed here seems to depend not only on the degree of charge and sulfation but also on a particular pattern of sulfation...
  59. ncbi Production of chondroitin sulfate and chondroitin
    Chiara Schiraldi
    Department of Experimental Medicine, Section of Biotechnology and Molecular Biology, Second University of Naples, via De Crecchio n degrees 7, 80138 Naples, Italy
    Appl Microbiol Biotechnol 87:1209-20. 2010
    ..In this paper we present an overview of the diverse applications and production methods of chondroitin reported so far in literature with a specific focus on novel microbial biotechnological approaches...
  60. ncbi Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1
    R Kokenyesi
    Joint Program in Neonatology, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 269:12304-9. 1994
    ..Thus, structural elements of the core protein other than the Ser-Gly attachment sites determine if a site will be glycanated and, if so, whether with chondroitin sulfate or heparan sulfate...
  61. ncbi Sulfation patterns and the amounts of chondroitin sulfate in the diamond squid, Thysanoteuthis rhombus
    Jun Ichi Tamura
    Department of Regional Environment, Faculty of Regional Sciences, Tottori University, Tottori, Japan
    Biosci Biotechnol Biochem 73:1387-91. 2009
    ..The arms, skin, and fin had non-sulfated chondroitin as the homogenous polymer. The skin and fin possessed larger amounts of chondroitin sulfate per unit of weight than the other tissues...
  62. ncbi Characterization of polyelectrolyte complexes between chondroitin sulfate and chitosan in the solid state
    Wen Bin Chen
    College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China
    J Biomed Mater Res A 75:128-37. 2005
    ..Furthermore, the swelling behavior of these complexes was pH dependent; this is a property that can potentially be exploited to control drug release from these complexes under specific pH conditions...
  63. pmc Exploiting enzyme specificities in digestions of chondroitin sulfates A and C: production of well-defined hexasaccharides
    Vitor H Pomin
    Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA
    Glycobiology 22:826-38. 2012
    ..In all, 15 CS hexasaccharides have been isolated and characterized. These serve as useful contributions to growing libraries of well-defined GAG oligosaccharides that can be used in further biophysical assays...
  64. pmc A tandem mass spectrometric approach to determination of chondroitin/dermatan sulfate oligosaccharide glycoforms
    May Joy C Miller
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, R 806, Boston, MA 02118, USA
    Glycobiology 16:502-13. 2006
    ..Decorin samples ranged from 30% CSB-like repeats for those samples from articular cartilage to 75% for those from sclera. These values agree with known levels of glucuronyl C5-epimerase in these tissues...
  65. ncbi Modulation of native chondroitin sulphate structure in tissue development and in disease
    B Caterson
    Division of Orthopaedic Surgery, University of North Carolina, Chapel Hill 27599 7055
    J Cell Sci 97:411-7. 1990
    ....
  66. ncbi Extracellular matrix in development of the intervertebral disc
    A J Hayes
    Connective Tissue Biology Group, School of Biosciences, Biomedical Sciences Building, Cardiff University, Museum Avenue, P.O. Box 911, Cardiff CF10 3US, UK
    Matrix Biol 20:107-21. 2001
    ....
  67. pmc Human genetic disorders caused by mutations in genes encoding biosynthetic enzymes for sulfated glycosaminoglycans
    Shuji Mizumoto
    Laboratory of Proteoglycan Signaling and Therapeutics, Graduate School of Life Science, Hokkaido University, Sapporo 001 0021 Japan
    J Biol Chem 288:10953-61. 2013
    ..This minireview focuses on growing glycobiological studies of recently described genetic diseases caused by disturbances in biosynthetic enzymes for sulfated GAGs...
  68. ncbi Effect of body temperature on chondroitinase ABC's ability to cleave chondroitin sulfate glycosaminoglycans
    Nicole J Tester
    Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida, USA
    J Neurosci Res 85:1110-8. 2007
    ..These findings are important for the design and interpretation of experimental and potential clinical studies involving Ch'ase ABC...
  69. ncbi Oversulfated chondroitin sulfate-E binds to BMP-4 and enhances osteoblast differentiation
    Tatsuya Miyazaki
    Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Sendai, Japan
    J Cell Physiol 217:769-77. 2008
    ..These results in the present study indicate that oversulfated CS, which possesses 4,6-disulfates in N-acetyl-galactosamine, binds to BMP-4 and promotes osteoblast differentiation and subsequent mineralization...
  70. ncbi Axonal regeneration of Clarke's neurons beyond the spinal cord injury scar after treatment with chondroitinase ABC
    Leung Wah Yick
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong
    Exp Neurol 182:160-8. 2003
    ..This result further suggests that CSPG is inhibitory to the regeneration of neurons in the spinal cord after traumatic injury...
  71. ncbi Human single-chain antibodies reactive with native chondroitin sulfate detect chondroitin sulfate alterations in melanoma and psoriasis
    Toon F C M Smetsers
    Department of Biochemistry, University Medical Centre, Nijmegen, NCMLS, HB Nijmegen, The Netherlands
    J Invest Dermatol 122:707-16. 2004
    ..In conclusion, human phage-display-derived anti-CS antibodies have been selected, characterized, and applied to detect CS alterations in skin conditions. Altered CS composition was detected in melanoma and psoriasis...
  72. ncbi Functions of chondroitin sulfate and heparan sulfate in the developing brain
    N Maeda
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo, 183 8526, Japan
    Neurochem Res 36:1228-40. 2011
    ..Recent studies have begun to reveal that the molecular interactions mediated by such glycosaminoglycan microdomains play critical roles in the various signaling pathways essential for the development of the brain...
  73. ncbi Quality of different chondroitin sulfate preparations in relation to their therapeutic activity
    Nicola Volpi
    Department of Biologia Animale, Biological Chemistry Section, University of Modena and Reggio Emilia, Modena, Italy
    J Pharm Pharmacol 61:1271-80. 2009
    ..We aim to review the quality control of chondroitin sulfate in pharmaceutical-grade preparations and nutraceuticals...
  74. ncbi Demonstration of the pleiotrophin-binding oligosaccharide sequences isolated from chondroitin sulfate/dermatan sulfate hybrid chains of embryonic pig brains
    Xingfeng Bao
    Department of Biochemistry, Kobe Pharmaceutical University, 4 19 1, Motoyama kita machi, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 280:35318-28. 2005
    ....
  75. ncbi Functions of chondroitin sulfate/dermatan sulfate chains in brain development. Critical roles of E and iE disaccharide units recognized by a single chain antibody GD3G7
    Anurag Purushothaman
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 282:19442-52. 2007
    ..Four discrete decasaccharide epitopic sequences were identified. The antibody GD3G7 has broad applications in investigations of CS/DS chains during the central nervous system's development and under various pathological conditions...
  76. ncbi Chondroitin sulfates are required for fibroblast growth factor-2-dependent proliferation and maintenance in neural stem cells and for epidermal growth factor-dependent migration of their progeny
    Swetlana Sirko
    Cell Morphology and Molecular Neurobiology, Ruhr University Bochum, Universitaetsstrasse, Bochum, Germany
    Stem Cells 28:775-87. 2010
    ..We conclude that neural stem/progenitor cell subpopulations reside in neurospheres that are distinguishable by their responsiveness to FGF-2 and EGF which is differentially regulated by CS-carbohydrate structures...
  77. ncbi Chondroitin sulfate characterized by the E-disaccharide unit is a potent inhibitor of herpes simplex virus infectivity and provides the virus binding sites on gro2C cells
    Kicki Bergefall
    Department of Clinical Virology, Goteborg University, Sweden
    J Biol Chem 280:32193-9. 2005
    ..Knowledge of the determinants of antiviral properties of CS-E will help in the development of inhibitors of herpes simplex virus infections in humans...
  78. pmc Oversulfated chondroitin sulfate interaction with heparin-binding proteins: new insights into adverse reactions from contaminated heparins
    Boyangzi Li
    Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Biochem Pharmacol 78:292-300. 2009
    ..In contrast to heparin, oversulfated chondroitin sulfate tightly binds factor XIIa suggesting a biochemical mechanism for the factor XIIa-based enhancement of vasoactive bradykinin production...
  79. ncbi Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum. Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases
    Chie Mitsunaga
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 281:18942-52. 2006
    ..These results suggest that the IdoUA-containing iA and iB units along with D/iD and E/iE units in the CS/DS hybrid play important roles in the formation of the cerebellar neural network during postnatal brain development...
  80. pmc The 3'-phosphoadenosine 5'-phosphosulfate transporters, PAPST1 and 2, contribute to the maintenance and differentiation of mouse embryonic stem cells
    Norihiko Sasaki
    Laboratory of Cell Biology, Department of Bioinformatics, Faculty of Engineering, Soka University, Hachioji, Tokyo, Japan
    PLoS ONE 4:e8262. 2009
    ..We propose that PAPST-dependent sulfation of HS or CS chains, which is regulated developmentally, regulates the extrinsic signaling required for the maintenance and normal differentiation of mESCs...
  81. ncbi Diversity in the degree of sulfation and chain length of the glycosaminoglycan moiety of urinary trypsin inhibitor isomers
    Ikuko Kakizaki
    Department of Biochemistry, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Biochim Biophys Acta 1770:171-7. 2007
    ..Our results demonstrate that UTI can vary in terms of both the degree of sulfation and the length of the low-sulfated chondroitin 4-sulfate chain...
  82. pmc Analysis of IgG with specificity for variant surface antigens expressed by placental Plasmodium falciparum isolates
    Ayman Khattab
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Malar J 3:21. 2004
    ....
  83. ncbi Chondroitin sulphate sulphation motif expression in the ontogeny of the intervertebral disc
    A J Hayes
    Connective Tissue Biology Laboratory and Cardiff Institute of Tissue Engineering and Repair, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, Wales, UK
    Eur Cell Mater 21:1-14. 2011
    ..Overall, our data suggests that differential sulphation of chondroitin correlates with significant events in development, growth and aging of the rat intervertebral disc...
  84. pmc Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma
    Martin A Thelin
    Department of Experimental Medical Science, Biomedical Center D12, Lund University, Lund, Sweden
    Cancer Res 72:1943-52. 2012
    ..Our findings show that IdoA in DS influences tumorigenesis by affecting cancer cell behavior. Therefore, downregulation of IdoA by DS-epi1 inhibitors may represent a new anticancer therapy...
  85. ncbi Development of a reconstructed cornea from collagen-chondroitin sulfate foams and human cell cultures
    N Engin Vrana
    METU, BIOMAT, Department of Biological Sciences, Biotechnology Research Unit, Ankara, Turkey
    Invest Ophthalmol Vis Sci 49:5325-31. 2008
    ....
  86. ncbi Serpin-independent anticoagulant activity of a fucosylated chondroitin sulfate
    Bianca F Glauser
    Laboratório de Tecido Conjuntivo, Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Ilha do Fundao, Caixa Postal 68041, Rio de Janeiro, RJ, 21941 590, Brazil
    Thromb Haemost 100:420-8. 2008
    ..In plasma systems, the serpin-independent anticoagulant effect of fucosylated chondroitin sulfate predominates over its serpin-dependent action. This glycosaminoglycan opens new avenues for the development of antithrombotic agents...
  87. ncbi Chondroitin sulfate functionalized liposomes for solid tumor targeting
    Rashmi Bagari
    Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr H S Gour Vishwavidyalaya, Sagar Madhya Pradesh, India
    J Drug Target 19:251-7. 2011
    ....
  88. ncbi Potential therapeutic application of chondroitin sulfate/dermatan sulfate
    Shuhei Yamada
    Laboratory of Proteoglycan Signaling and Therapeutics, Frontier Research Center for Post Genomic Science and Technology, Hokkaido University Graduate School of Life Science, Nishi 11 choume, Kita 21 jo, Kita ku, Sapporo, Hokkaido 001 0021, Japan
    Curr Drug Discov Technol 5:289-301. 2008
    ..Specific saccharide structures in CS/DS chains appear to be involved in tumor cell proliferation and metastasis. The detection and identification of such CS/DS saccharide sequences would be an important contribution to cancer therapy...
  89. pmc Composition of the endothelial glycocalyx and its relation to its thickness and diffusion of small solutes
    Lujia Gao
    Department of Bioengineering, The Pennsylvania State University, University Park, PA 16802, USA
    Microvasc Res 80:394-401. 2010
    ..This behavior suggests that the removal of heparan sulfate may cause a collapse of the glycocalyx which counters decreases in thickness by compacting the layer to maintain a constant resistance to filtration...
  90. ncbi Oversulfated chondroitin sulfate plays critical roles in the neuronal migration in the cerebral cortex
    Maki Ishii
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Musashidai, Fuchu, Tokyo 183 8526, Japan
    J Biol Chem 283:32610-20. 2008
    ..These results revealed that specific oversulfated structures in CS chains play critical roles in the migration of neuronal precursors during cortical development...
  91. ncbi Perineuronal net formation and structure in aggrecan knockout mice
    K A Giamanco
    Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Neuroscience 170:1314-27. 2010
    ..Together our work has served to assess the contribution of aggrecan to PNN formation while providing key evidence concerning the molecular composition of PNNs in addition to determining how these components ultimately form PNNs...
  92. ncbi Influence of glial-derived matrix molecules, especially chondroitin sulfates, on neurite growth and survival of cultured mouse embryonic motoneurons
    Alice Klausmeyer
    Department of Cellmorphology and Molecular Neurobiology, Laboratory of Molecular Cellbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany
    J Neurosci Res 89:127-41. 2011
    ..The results indicate that molecules of the ECM, especially chondroitin sulfates, play an important role as axon growth-promoting cues...
  93. ncbi Human milk glycosaminoglycans inhibit HIV glycoprotein gp120 binding to its host cell CD4 receptor
    D S Newburg
    Shriver Center for Mental Retardation, Waltham, MA 02254
    J Nutr 125:419-24. 1995
    ..We speculate that this human milk glycosaminoglycan could limit the rate of postnatal vertical transmission of HIV in breast-fed infants of HIV-infected mothers...
  94. ncbi Preparation of chondroitin sulfate nanocapsules for use as carries by the interfacial polymerization method
    Juqun Xi
    Department of Pharmacology, Medical School of Yangzhou University, Yangzhou, People s Republic of China
    Int J Biol Macromol 50:157-63. 2012
    ..The in vitro drug release of IND-loaded nanocapsules and IND/ChSMA self-assemblies were also carried out in simulated body fluid pH 7.4 at 37°C...
  95. pmc Structural interactions in chondroitin 4-sulfate mediated adherence of Plasmodium falciparum infected erythrocytes in human placenta during pregnancy-associated malaria
    Rajeshwara N Achur
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Biochemistry 47:12635-43. 2008
    ..These data have important implications for the development and evaluation of therapeutics and vaccine for placental malaria...
  96. pmc Chondroitin sulphate inhibits connective tissue mast cells
    T C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts, MA 02111, USA
    Br J Pharmacol 131:1039-49. 2000
    ..5. Chondroitin sulphate appears to be a potent mast cell inhibitor of allergic and nonimmune stimulation with potential clinical implications...
  97. ncbi Preparation and properties of chitosan chondroitin sulfate complex microcapsules
    Weiping Sui
    School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China
    Colloids Surf B Biointerfaces 65:69-73. 2008
    ..The results of the release kinetics experiments of the microcapsules showed that the drug released slightly faster in acid media than in alkali ones...
  98. pmc Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events
    Marco Guerrini
    Istituto di Ricerche Chimiche e Biochimiche G Ronzoni, Città Studi, via Giuseppe, Colombo 81, 20133 Milan, Italy
    Nat Biotechnol 26:669-75. 2008
    ..Our analysis suggests effective screening methods that can be used to determine whether or not heparin lots contain the contaminant reported here...
  99. ncbi The mobility of chondroitin sulfate in articular and artificial cartilage characterized by 13C magic-angle spinning NMR spectroscopy
    Holger A Scheidt
    Institute of Medical Physics and Biophysics, University of Leipzig, Härtelstrasse 16 18, Leipzig, Germany
    Biopolymers 93:520-32. 2010
    ..This could also be confirmed by macroscopic biomechanical elasticity measurements. Nevertheless, these results suggest that NMR is a useful tool for the investigation of the quality of artificially engineered tissue...
  100. ncbi Anti-arthritic action mechanisms of natural chondroitin sulfate in human articular chondrocytes and synovial fibroblasts
    Keisuke Imada
    Department of Biochemistry and Molecular Biology, Tokyo University of Pharmacy and Life Sciences, School of Pharmacy, Hachioji, Tokyo 192 0392, Japan
    Biol Pharm Bull 33:410-4. 2010
    ..It is noteworthy that CS is able to modulate the function of synovial fibroblasts as well as that of chondrocytes. Therefore, CS is very likely to be multifunctional chondroprotective material for degenerative arthritic diseases...
  101. ncbi Single, high-dose intraspinal injection of chondroitinase reduces glycosaminoglycans in injured spinal cord and promotes corticospinal axonal regrowth after hemisection but not contusion
    Tsutomu Iseda
    W M Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, USA
    J Neurotrauma 25:334-49. 2008
    ....

Research Grants67

  1. Parvalbumin-Containing Neurons in Schizophrenia
    Tsung Ung W Woo; Fiscal Year: 2013
    ..Findings of the proposed studies are expected to shed light on the conceptualization of treatment and prevention strategies that aim at fundamentally correcting the underlying neural circuit deficits. ..
  2. Glycosaminoglycans and Cell Traffic in the Lymphatic Microenvironment
    Mark M Fuster; Fiscal Year: 2012
    ..This work may lead to novel therapy to inhibit the spread, morbidity, and mortality of cancer in our Veteran population. ..
  3. Adhesion of Leptospira interrogans to Human Cell Surface Receptors
    Jenifer L Coburn; Fiscal Year: 2010
    ..abstract_text> ..
  4. Chondroitin Sulfate Proteoglycan and Myelination in Intraventricular Hemorrhage
    Praveen Ballabh; Fiscal Year: 2010
    ..To address these issues, we will use prematurely delivered rabbit pups as an experimental animal and will also use autopsy materials from premature infants with and without brain hemorrhage. ..
  5. Disruption of Extracellular Matrix-Glial Interactions in Schizophrenia
    Sabina Berretta; Fiscal Year: 2013
    ....
  6. HDAC6: a target for regeneration following injury in the nervous system
    BRETT CAMERON LANGLEY; Fiscal Year: 2013
    ..Our findings in this project could lead to new treatments for spinal cord injury and other central nervous system injuries and disease. ..
  7. Neurotransplantation and Training to Promote Recovery of Chronic SCI Cats
    Michel A Lemay; Fiscal Year: 2013
    ..This will be a novel application of neuroregeneration and neurorehabilitation techniques to increase our understanding of the potential for repair after SCI. ..
  8. Oligosaccharide moieties of human milk glycans that inhibit pathogens
    David S Newburg; Fiscal Year: 2013
    ..The availability of synthetic human milk glycans suitable for oral consumption that inhibit HIV or rotavirus could have large impact on these important threats to public health. ..
  9. Synthetic Oligosaccharides for Probing Infection and Innate Immunity
    Geert Jan Boons; Fiscal Year: 2013
    ..for the synthesis of libraries of lipopolysaccharides (LPS), glycosylphosphatidylinositol (GPI) anchors and chondroitin sulfates (CS), and employ the resulting compounds to examine in detail the molecular aspects of several infectious ..
  10. Interphotoreceptor Matrix Based Cell Delivery Vehicle for Retinal Regeneration
    Rebecca L Carrier; Fiscal Year: 2012
    ..Here, the natural structural and biochemical cues provided by native interphotoreceptor matrix (IPM) will be used to promote RPC survival and integration into adjacent host retina. ..
  11. Metabolic Engineering of Chinese Hamster Ovary Cells for Production of Heparin
    Susan T Sharfstein; Fiscal Year: 2011
    ..Scale-up the production and recovery of CHO cell metabolically engineered heparin while maintaining chemical and bioequivalence. ..
  12. FIBRONECTIN REGULATION OF CARCINOMA APOPTOSIS
    Yvonne Kapila; Fiscal Year: 2009
    ..These studies will help explain some of the cell-matrix interactions and signaling mechanisms that regulate tumor cell biology, and may provide insights into the pathogenesis of oral SCC. ..
  13. NG2 cell dynamics in the normal and injured adult central nervous system
    Ethan Hughes; Fiscal Year: 2012
    ....
  14. SEQUENCING THE POLYSACCHARIDE COMPONENT OF PROTEOGLYCANS
    Robert J Linhardt; Fiscal Year: 2012
    ..Currently it is difficult to analyze and not possible to sequence these complex polysaccharides. This has prevented a firm understanding of the structure- activity relationship of this important class of biomacromolecules. ..
  15. Extracellular anomalies in Schizophrenia: from molecules to symptoms
    Sabina Berretta; Fiscal Year: 2013
    ..Biopsy donors will be tested for olfactory functions and on psychiatric rating scales. BD subjects will be included to test whether CSPG abnormalities are specific to SZ or represent a shared feature among major psychoses. ..
  16. Hematopoietic Stem Cell Differentiation to Macrophages
    E Richard Stanley; Fiscal Year: 2013
    ..2. To define and compare the activities, expression patterns and regulation of IL-34 and CSF-1. 3. To establish the biological relationships between IL-34, CSF-1 and the CSF-1 receptor ..
  17. Bioengineered scaffolds for peripheral nerve repair
    Ravi V Bellamkonda; Fiscal Year: 2010
    ..This research will advance our understanding of the mechanisms of peripheral nerve regeneration, and develops technologies that are likely to improve clinical outcomes after peripheral nerve injury. ..
  18. Functional characterization of a novel gene for non-alcoholic fatty liver disease
    ALEXIS L GORDEN; Fiscal Year: 2011
    ..This research may lead to novel targets and strategies for prevention and treatment of NAFLD. ..
  19. Self-assembling Biomimetic Hydrogels with Bioadhesive Properties for Intervertebr
    ANDREA JENNIFER VERNENGO; Fiscal Year: 2013
    ....
  20. New probes for matrix metalloproteinase 13
    Gregg B Fields; Fiscal Year: 2013
    ..In addition, a unique mode of MMP inhibition will be identified. ..
  21. Role of NG2 in diabetic nephropathy
    Vesselina G Cooke; Fiscal Year: 2010
    ..Collectively these studies will elucidate novel mechanisms associated with early diabetic nephropathy and open new avenues to explore therapies. ..
  22. Pregnancy specific glycoprotein 1 activates transforming growth factor beta
    Gabriela S Dveksler; Fiscal Year: 2013
    ..This project will define the mechanism of action o PSG1 and address a possible novel mechanism of TGF-b1 and TGF-b2 activation. ..
  23. Chondrogenic composite grafts for the repair of cartilage defects
    Jie Song; Fiscal Year: 2010
    ..The successful development of viable synthetic cartilage constructs has significant social and economic implications, and contributes to improving the musculoskeletal health of the general population. ..
  24. Newborn Screening and Biomarkers for Mucopolysaccharidoses
    Shunji Tomatsu; Fiscal Year: 2013
    ..In addition to the NBS application we will measure GAGs as biomarkers for assessing disease severity and monitoring the effects of evolving therapies over a long clinical course. ..
  25. Chondroitin sulfate-fiber hydrogels for cartilage tissue engineering
    Jeannine Coburn; Fiscal Year: 2012
    ..Therefore, it is necessary to design new surgical interventions to enhance the current treatments with the use of biomaterials. ..
  26. Molecular Mechanisms of Plasmodium Falciparum Adherence to the Human Placenta
    Susan J Fisher; Fiscal Year: 2010
    ..Our proposed work will realistically aid the malaria field in identifying potential drug and vaccine targets. ..
  27. Small molecule protein-glycan inhib. as malaria transmission-blocking therapuetic
    RHOEL DAVID RAMOS DINGLASAN; Fiscal Year: 2013
    ....
  28. Controlled Release Scaffolds for Nerve Regeneration
    Lonnie D Shea; Fiscal Year: 2013
    ..Controllable systems such as this will identify the contribution of each component to functional outcome, and can be tuned to obtain the functionality necessary for translation to the clinic. ..
  29. Syndecan-1 and the Arterial Response to Injury
    Alexander W Clowes; Fiscal Year: 2013
    ....
  30. Targeting Pericytes in Cancer
    Raghu Kalluri; Fiscal Year: 2013
    ..Our proposal is designed to functionally determine the contribution of pericytes in primary tumor growth and metastasis, and identify new therapies to inhibit metastasis. ..
  31. Functional Testing of KLF7 in Spinal Cord Injury: An Optogenetic Approach
    Murray G Blackmore; Fiscal Year: 2013
    ....
  32. Genetic dissection of the role of chondroitin sulfate in cartilage
    Yu Yamaguchi; Fiscal Year: 2013
    ..By these studies, we wish to gain novel insight into the molecular mechanisms of cartilage degeneration in OA, and to translate our observations in mice into the identification of novel susceptibility genes for human OA. ..
  33. Resource for Integrated Glycotechnology
    James H Prestegard; Fiscal Year: 2011
    ..Technology is disseminated through extensive training programs and additional collaborations and service functions hosted by the Resource. ..
  34. Resource for Integrated Glycotechnology
    Kelley W Moremen; Fiscal Year: 2013
    ..Technology is disseminated through extensive training programs and additional collaborations and service functions hosted by the Resource. ..
  35. Glycan Modulation of Inflammatory Responses
    Ajit P Varki; Fiscal Year: 2013
    ..abstract_text> ..
  36. Physiologic Mechanisms of Action of APP and APLP2 in Axon Targeting
    Mark W Albers; Fiscal Year: 2013
    ..abstract_text> ..
  37. Targeting Endogenous Inhibitors to Enhance Spinal Axon Regeneration After Injury
    Ronald L Schnaar; Fiscal Year: 2012
    ..Destroying or blocking these molecules may permit axons to regenerate, greatly enhancing functional recovery. ..
  38. MECHANISMS IN THE REMODELING OF LUNG STRUCTURE
    Michael J Holtzman; Fiscal Year: 2012
    ..This application builds on a long history of productive research and collaboration related to mechanisms of lung remodeling and the response to pulmonary injury. ..
  39. Plasticity of intact circuits restores function after a spinal cord injury.
    WILLIAM BEN CAFFERTY; Fiscal Year: 2012
    ..abstract_text> ..
  40. Recovery of bladder reflexes and nerve regeneration after spinal cord injury
    Yu Shang Lee; Fiscal Year: 2013
    ..This multipartite strategy has the potential to lead to an unprecedented amount of functional plasticity/regeneration and bladder recovery after SCI. ..
  41. Cell-Cell Signaling in Development and Regeneration of Visual Connections
    John G Flanagan; Fiscal Year: 2013
    ..Further studies will provide improved understanding of these molecular interactions, with potential implications for development, degeneration and regeneration. ..
  42. PKC inhibition-mediated spinal cord regeneration
    Xiao Ming Xu; Fiscal Year: 2009
    ....
  43. PROTEOGLYCANS, SYNAPTIC PLASTICITY IN AGING AND DISEASE
    Paul E Gottschall; Fiscal Year: 2010
    ..Should synaptic remodeling be altered, due to diminished proteolytic cleavage of brevican, stimulation of proteolysis may be of therapeutic value. ..
  44. A chemical approach to elucidating the structure-function relationships of chondr
    Linda C Hsieh-Wilson; Fiscal Year: 2013
    ....
  45. Novel Method for Imaging Cartilage
    Ravinder Reddy Regatte; Fiscal Year: 2010
    ..The proposed R21 developmental project will allow us to establish a new method via chemical exchange dependent saturation transfer (CEST) contrast modality for detecting early degenerative changes in cartilage. ..
  46. Development of a Bioengineered Heparin from a Non-Animal Source
    Robert J Linhardt; Fiscal Year: 2013
    ..This process will improve the safety and uniformity of heparin and prevent future contamination or adulteration of this important drug that is administered to several hundred thousand patients each day in the US. ..
  47. Combinatorial targeting of melanoma initiating cells
    Soldano Ferrone; Fiscal Year: 2012
    ....
  48. BIOSYNTHESIS OF COMPLEX CARBOHYDRATES IN BRAIN
    LENNART RODEN; Fiscal Year: 1993
    ..of Munster, which demonstrate that a patient with a progeria-like syndrome is deficient in galactosyltransferase I. This finding is the first demonstration of a genetic defect in proteoglycan biosynthesis in humans...
  49. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2009
    ..Moreover these results will be broadly applicable to other CNS regions where work continues towards understanding the formation of boundaries and topographic maps. ..
  50. Therapeutic Targeting of Intracellular Mechanisms Involved in Glial Scar Formatio
    Damien D Pearse; Fiscal Year: 2013
    ....
  51. Mechanisms Underlying Inhibition of Regeneration in CNS Neurons
    ANDREA LYNN JOHNSTONE; Fiscal Year: 2010
    ....
  52. Polymer Membrane Ion/Gas/Polyion Sensors: New Frontiers
    Mark E Meyerhoff; Fiscal Year: 2013
    ....
  53. MUCOPOLYSACCHARIDOSES AND CATHEPSIN K
    Dieter Bromme; Fiscal Year: 2007
    ..Altogether, these studies should elucidate the impact of GAGs in MPS on bone resorption catalyzed by cathepsin K. ..
  54. Molecular Determinants of Adult CNS Axonal Growth
    Stephen M Strittmatter; Fiscal Year: 2010
    ..This work is critical to optimize the opportunity for development of clinical methods to increase axonal growth and improve functional recovery from neurological damage. ..
  55. NERVOUS TISSUE GLYCOCONJUGATES
    RICHARD MARGOLIS; Fiscal Year: 2000
    ..g.,following spinal cord injury or stroke), where there is experimental evidence that they may have therapeutic utility. ..
  56. PROTEOGLYCAN SYNTHESIS DURING DEVELOPMENT AND AGING
    Arnold Caplan; Fiscal Year: 1999
    ..chemical and structural information gained from the first experimental program to study subtle changes in chondroitin sulfates of chick aggrecan obtained from chick limb bud chondrocytes cultured and extracted at different ..
  57. PROTEOGLYCAN SYNTHESIS IN MUTANT MOUSE SYSTEMS
    Nancy B Schwartz; Fiscal Year: 2013
    ..2) Elucidate the mechanism by which absence of CSPG core protein or CS chains affects IHH and FGF signaling throughout growth development. ..
  58. Quantifying Axon Growth in Complex Environments
    Diane Hoffman Kim; Fiscal Year: 2010
    ..The proposed research seeks to solve this problem by quantifying how guidance cues, both individually and in combination, promote axon growth in an inhibitory environment such as a nerve injury site. ..
  59. TYPE IV COLLAGEN IN MELANOMA CELL INVASION & METASTASIS
    James McCarthy; Fiscal Year: 1999
    ..In addition, these studies may provide a first generation of structurally constrained compounds that could be useful in metastasis management in vivo. ..
  60. Characterization of Anticoagulant Heparin and Related Polysaccharides
    RAM contact SASISEKHARAN; Fiscal Year: 2010
    ..In this proposal we seek to build on our experience and expertise in employing robust analytical methods to structurally and functionally define heparin. ..
  61. CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    Steven Rosen; Fiscal Year: 2009
    ..As the molecular machinery of normal lymphocyte homing is elucidated, new targets for anti-inflammatory therapeutics are likely to emerge. ..
  62. PERLECAN AND CHONDROGENESIS
    Daniel Carson; Fiscal Year: 2004
    ..These studies provide novel opportunities to use perlecan or perlecan fragments as inducers of chondrogenesis for design of therapeutic strategies to replace damaged or surgically-removed cartilage. ..
  63. BIOCHEMISTRY OF MAST CELL SECRETORY GRANULE ENZYMES
    Lawrence Schwartz; Fiscal Year: 1999
    ....
  64. COMPLEX CARBOHYDRATES OF NERVOUS TISSUE
    RICHARD MARGOLIS; Fiscal Year: 2001
    ....
  65. MOLECULAR MECHANISMS IN METASTASIS--ROLE OF FIBRONECTIN
    LEO FURCHT; Fiscal Year: 2001
    ..The overall goal in these studies is to define the molecular mechanisms that regulate CSPG/alpha4beta1 integrin interactions and to evaluate their importance in tumor cell adhesion, invasion and metastasis. ..
  66. PROTEOGLYCANS IN THE PATHOGENESIS OF ATHEROSCLEROSIS
    Gerald Berenson; Fiscal Year: 1992
    ..These studies will help to clarify the role of PG in the pathogenesis of atherosclerosis...
  67. LEWIS X OLIGOSACCHARIDE IN THE EMBRVONIC CNS
    Paul Patterson; Fiscal Year: 1999
    ..If the available mice are not deficient in brain Lex , we will collaborate on cloning and disrupting a brain-enriched form of Fuc-T. ..