glycogen

Summary

Top Publications

  1. pmc Development of a transformation system for Chlamydia trachomatis: restoration of glycogen biosynthesis by acquisition of a plasmid shuttle vector
    Yibing Wang
    Molecular Microbiology Group, University of Southampton Medical School, Southampton General Hospital, Southampton, United Kingdom
    PLoS Pathog 7:e1002258. 2011
  2. pmc Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila
    Balázs Erdi
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest, Hungary
    Autophagy 8:1124-35. 2012
  3. ncbi Glycogen and its metabolism: some new developments and old themes
    Peter J Roach
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biochem J 441:763-87. 2012
  4. ncbi Requirement of glycogenolysis for uptake of increased extracellular K+ in astrocytes: potential implications for K+ homeostasis and glycogen usage in brain
    Junnan Xu
    Department of Clinical Pharmacology, China Medical University, No 92 Beier Road, Heping District, Shenyang, People s Republic of China
    Neurochem Res 38:472-85. 2013
  5. pmc Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila
    Kanyan Xu
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Metab 8:289-300. 2008
  6. pmc Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
    Edward J McManus
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee, Scotland
    EMBO J 24:1571-83. 2005
  7. ncbi Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake
    Jennifer A Calvo
    Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
    J Appl Physiol (1985) 104:1304-12. 2008
  8. pmc Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder--murine Pompe disease
    Nina Raben
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Autophagy 6:1078-89. 2010
  9. pmc Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1
    Tengfei Zhang
    State Key Lab of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 20032, China
    Cell Metab 15:75-87. 2012
  10. ncbi Unexpected and widespread connections between bacterial glycogen and trehalose metabolism
    Govind Chandra
    Departments of Biological Chemistry and Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
    Microbiology 157:1565-72. 2011

Detail Information

Publications316 found, 100 shown here

  1. pmc Development of a transformation system for Chlamydia trachomatis: restoration of glycogen biosynthesis by acquisition of a plasmid shuttle vector
    Yibing Wang
    Molecular Microbiology Group, University of Southampton Medical School, Southampton General Hospital, Southampton, United Kingdom
    PLoS Pathog 7:e1002258. 2011
    ..trachomatis to synthesise and accumulate glycogen within inclusions...
  2. pmc Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila
    Balázs Erdi
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest, Hungary
    Autophagy 8:1124-35. 2012
    ..Loss of Rack1 led to attenuated autophagic response to starvation, and glycogen stores were decreased 11.8-fold in Rack1 mutant cells...
  3. ncbi Glycogen and its metabolism: some new developments and old themes
    Peter J Roach
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biochem J 441:763-87. 2012
    b>Glycogen is a branched polymer of glucose that acts as a store of energy in times of nutritional sufficiency for utilization in times of need...
  4. ncbi Requirement of glycogenolysis for uptake of increased extracellular K+ in astrocytes: potential implications for K+ homeostasis and glycogen usage in brain
    Junnan Xu
    Department of Clinical Pharmacology, China Medical University, No 92 Beier Road, Heping District, Shenyang, People s Republic of China
    Neurochem Res 38:472-85. 2013
    ..This will allow Kir1.4-mediated release and reuptake by the less powerful neuronal Na(+),K(+)-ATPase...
  5. pmc Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila
    Kanyan Xu
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Metab 8:289-300. 2008
    ..tissues, in particular in the fat body, also display increased food consumption but have decreased levels of glycogen and a higher sensitivity to starvation...
  6. pmc Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
    Edward J McManus
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee, Scotland
    EMBO J 24:1571-83. 2005
    The inactivation of glycogen synthase kinase (GSK)3 has been proposed to play important roles in insulin and Wnt signalling...
  7. ncbi Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake
    Jennifer A Calvo
    Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
    J Appl Physiol (1985) 104:1304-12. 2008
    ..Thus this study demonstrates that upregulation of PGC-1alpha in muscle in vivo is sufficient to greatly improve exercise performance under various exercise paradigms as well as increase peak oxygen uptake...
  8. pmc Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder--murine Pompe disease
    Nina Raben
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Autophagy 6:1078-89. 2010
    ..disease, a lysosomal storage disorder in which acid alphaglucosidase, the enzyme involved in the breakdown of glycogen, is deficient or absent. Clinically the disease manifests as a cardiac and skeletal muscle myopathy...
  9. pmc Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1
    Tengfei Zhang
    State Key Lab of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 20032, China
    Cell Metab 15:75-87. 2012
    b>Glycogen phosphorylase (GP) catalyzes the rate-limiting step in glycogen catabolism and plays a key role in maintaining cellular and organismal glucose homeostasis...
  10. ncbi Unexpected and widespread connections between bacterial glycogen and trehalose metabolism
    Govind Chandra
    Departments of Biological Chemistry and Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
    Microbiology 157:1565-72. 2011
    b>Glycogen, a large α-glucan, is a ubiquitous energy storage molecule among bacteria, and its biosynthesis by the classical GlgC-GlgA pathway and its degradation have long been well understood - or so we thought...
  11. pmc Regulation of glycogen metabolism in yeast and bacteria
    Wayne A Wilson
    Biochemistry and Nutrition Department, Des Moines University, Des Moines, IA, USA
    FEMS Microbiol Rev 34:952-85. 2010
    ..b>Glycogen biosynthesis is a main strategy for such metabolic storage, and a variety of sensing and signaling mechanisms ..
  12. ncbi Global regulation by the small RNA-binding protein CsrA and the non-coding RNA molecule CsrB
    T Romeo
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center at Fort Worth, 76107 2699, USA
    Mol Microbiol 29:1321-30. 1998
    ..b>Glycogen synthesis and catabolism, gluconeogenesis, glycolysis, motility, cell surface properties and adherence are ..
  13. ncbi CsrA regulates glycogen biosynthesis by preventing translation of glgC in Escherichia coli
    Carol S Baker
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    Mol Microbiol 44:1599-610. 2002
    ..CsrA binding to glgCAP transcripts inhibits glycogen metabolism by promoting glgCAP mRNA decay...
  14. ncbi The evolution of glycogen and starch metabolism in eukaryotes gives molecular clues to understand the establishment of plastid endosymbiosis
    Steven Ball
    Unite de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS USTL, Batiment C9, Cite Scientifique, F 59655 Villeneuve d Ascq, France
    J Exp Bot 62:1775-801. 2011
    Solid semi-crystalline starch and hydrosoluble glycogen define two distinct physical states of the same type of storage polysaccharide...
  15. ncbi From bacterial glycogen to starch: understanding the biogenesis of the plant starch granule
    Steven G Ball
    Laboratoire de Chimie Biologique, UMR 8576 du CNRS, Universite des Sciences et Technologies de Lille, Bâtiment C9 Cité Scientifique, France
    Annu Rev Plant Biol 54:207-33. 2003
    ..Plant starch metabolism can be distinguished from that of bacterial glycogen by the presence of multiple forms of enzyme activities for each step of the pathway...
  16. pmc Identification and molecular characterization of csrA, a pleiotropic gene from Escherichia coli that affects glycogen biosynthesis, gluconeogenesis, cell size, and surface properties
    T Romeo
    Department of Microbiology and Immunology, University of North Texas, Fort Worth 76107 2699
    J Bacteriol 175:4744-55. 1993
    ..metabolic pathways that is transcriptionally activated in the stationary phase is the pathway for biosynthesis of glycogen. To identify factors that regulate glycogen biosynthesis in trans, a collection of transposon mutants was ..
  17. ncbi Astrocyte glycogen and brain energy metabolism
    Angus M Brown
    School of Biomedical Sciences, Queens Medical Centre, University of Nottingham, Nottingham, NG7 2UH, United Kingdom
    Glia 55:1263-71. 2007
    The brain contains glycogen but at low concentration compared with liver and muscle. In the adult brain, glycogen is found predominantly in astrocytes...
  18. ncbi Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt
    Cora Weigert
    Dept of Internal Medicine, Div of Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry, Univ of Tübingen, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    Am J Physiol Endocrinol Metab 289:E251-7. 2005
    Previous studies showed an insulin-"desensitizing" action of IL-6 on glycogen synthesis in hepatocytes. We recently found no inhibition of the proximal steps of the insulin signal cascade in human skeletal muscle cells...
  19. pmc Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice
    Tounkang Sambou
    Université Paul Sabatier Toulouse III 118, route de Narbonne, 31062 Toulouse Cedex 04, France
    Mol Microbiol 70:762-74. 2008
    Mycobacterium tuberculosis and other pathogenic mycobacterial species produce large amounts of a glycogen-like alpha-glucan that represents the major polysaccharide of their outermost capsular layer...
  20. ncbi Glycogen in Bacillus subtilis: molecular characterization of an operon encoding enzymes involved in glycogen biosynthesis and degradation
    J A Kiel
    Department of Genetics, State University of Groningen, Haren, The Netherlands
    Mol Microbiol 11:203-18. 1994
    Although it has never been reported that Bacillus subtilis is capable of accumulating glycogen, we have isolated a region from the chromosome of B. subtilis containing a glycogen operon...
  21. ncbi Glycogen is a preferred glutamate precursor during learning in 1-day-old chick: biochemical and behavioral evidence
    Marie E Gibbs
    Department of Anatomy and Cell Biology, Monash University, Clayton, Victoria, Australia
    J Neurosci Res 85:3326-33. 2007
    ..of biochemical events, including glutamate release, increase in forebrain level of glutamate and utilization of glycogen and glucose...
  22. pmc Brain glycogen content and metabolism in subjects with type 1 diabetes and hypoglycemia unawareness
    GULIN OZ
    Department of Radiology, Center for Magnetic Resonance Research, Medical School, University of Minnesota, Minneapolis, Minnesota, USA
    J Cereb Blood Flow Metab 32:256-63. 2012
    Supercompensated brain glycogen may contribute to the development of hypoglycemia unawareness in patients with type 1 diabetes by providing energy for the brain during periods of hypoglycemia...
  23. ncbi Physiological control of liver glycogen metabolism: lessons from novel glycogen phosphorylase inhibitors
    Loranne Agius
    Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne NE24HH, UK
    Mini Rev Med Chem 10:1175-87. 2010
    Liver glycogen is synthesized in the postprandial state in response to elevated concentrations of glucose and insulin or by activation of neuroendocrine signals and it is degraded in the postabsorptive state in response to changes in the ..
  24. ncbi Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content
    C Keller
    The Copenhagen Muscle Research Centre, Department of Infectious Diseases, University of Copenhagen, Denmark
    FASEB J 15:2748-50. 2001
    ..of 180 min of two-legged dynamic knee extensor with either normal or low (~60% of control) pre-exercise muscle glycogen levels. Increases in plasma IL-6 during exercise were significantly higher (P<0...
  25. ncbi Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells
    Elena Favaro
    Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Cell Metab 16:751-64. 2012
    ..Hypoxia in tumors represents a hostile environment that can encourage these transformations. We report that glycogen metabolism is upregulated in tumors in vivo and in cancer cells in vitro in response to hypoxia...
  26. pmc Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress
    Kwai Wa Cheng
    Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    EMBO Mol Med 4:125-41. 2012
    ..Unexpectedly, Rab25 induced the accumulation of glycogen in epithelial cancer cells, a process not previously identified...
  27. ncbi The effect of the acanthocephalan parasite Pomphorhynchus laevis on the lipid and glycogen content of its intermediate host Gammarus pulex
    S J Plaistow
    Equipe Ecologie Evolutive, UMR CNRS 5561 Biogeosciences, Universite de Bourgogne, 6 Boulevard Gabriel, 21000 Dijon, France
    Int J Parasitol 31:346-51. 2001
    ..presence of the acanthocephalan parasite, Pomphorhynchus laevis, and inter-individual variation in the lipid and glycogen content of its crustacean host, Gammarus pulex (Amphipoda)...
  28. pmc Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1
    Nuria Pescador
    Departamento de Bioquimica, Universidad Autonoma de Madrid, Madrid, Spain
    PLoS ONE 5:e9644. 2010
    ..Here we show that oxygen regulates the expression of the muscle glycogen synthase (GYS1). Hypoxic GYS1 induction requires HIF activity and a Hypoxia Response Element within its promoter...
  29. pmc The molecular basis of glycogen breakdown and transport in Streptococcus pneumoniae
    D Wade Abbott
    Biochemistry and Microbiology, University of Victoria, PO Box 3055 STN CSC, Victoria, BC, Canada V8W 3P6
    Mol Microbiol 77:183-99. 2010
    ..We show that of the commonly occurring exogenous alpha-glucans, S. pneumoniae TIGR4 is only able to grow on glycogen in a MalX- and SpuA-dependent manner...
  30. ncbi Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle
    Michale Bouskila
    Am J Physiol Endocrinol Metab 294:E28-35. 2008
    Insulin promotes dephosphorylation and activation of glycogen synthase (GS) by inactivating glycogen synthase kinase (GSK) 3 through phosphorylation...
  31. ncbi PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism
    J A Printen
    Department of Physiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Science 275:1475-8. 1997
    ..A PP1C-targeting protein expressed in 3T3-L1 adipocytes (called PTG, for protein targeting to glycogen) was cloned and characterized. PTG was expressed predominantly in insulin-sensitive tissues...
  32. pmc Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG)
    Carolyn A Worby
    Department of Pharmacology, University of California at San Diego, La Jolla, California 92093 0721, USA
    J Biol Chem 283:4069-76. 2008
    ..A hallmark of LD is the accumulation of insoluble glycogen in the cytoplasm of cells from most tissues...
  33. ncbi Glycogen synthase kinase 3: a key regulator of cellular fate
    J E Forde
    Biomedical Sciences Building, Cardiff School of Biosciences, Museum Avenue, CF10 3US, Cardiff, UK
    Cell Mol Life Sci 64:1930-44. 2007
    The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified as a key regulator of insulin-dependent glycogen synthesis...
  34. ncbi AMPK: a key sensor of fuel and energy status in skeletal muscle
    D Grahame Hardie
    Division of Molecular Physiology, University of Dundee, Dundee, Scotland
    Physiology (Bethesda) 21:48-60. 2006
    ..Recent work using a muscle-specific knockout of the upstream kinase, LKB1, has confirmed that the LKB1-->AMPK cascade is the signaling pathway responsible for many of these effects...
  35. ncbi Clinical outcomes after long-term treatment with alglucosidase alfa in infants and children with advanced Pompe disease
    Marc Nicolino
    Division of Pediatric Endocrinology, Diabetology and Metabolism, Hopital Debrousse, University Lyon, Lyon, France
    Genet Med 11:210-9. 2009
    ..A clinical trial was conducted to evaluate the safety and efficacy of alglucosidase alfa in infants and children with advanced Pompe disease...
  36. ncbi Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle
    Michale Bouskila
    University of Dundee, Scotland, UK
    Cell Metab 12:456-66. 2010
    b>Glycogen synthase (GS), a key enzyme in glycogen synthesis, is activated by the allosteric stimulator glucose-6-phosphate (G6P) and by dephosphorylation through inactivation of GS kinase-3 with insulin...
  37. ncbi Functional significance of brain glycogen in sustaining glutamatergic neurotransmission
    Helle M Sickmann
    Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Neurochem 109:80-6. 2009
    The involvement of brain glycogen in sustaining neuronal activity has previously been demonstrated...
  38. ncbi Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells
    R B Ceddia
    Department of Biology, York University, Toronto, ON, M3J 1P3, Canada
    Diabetologia 48:132-9. 2005
    ..The aim of this study was to determine whether adiponectin elicits glucose uptake via increased GLUT4 translocation and to investigate the metabolic fate of glucose in skeletal muscle cells treated with globular adiponectin...
  39. ncbi n-3 fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed a high-fat diet
    O Kuda
    Department of Adipose Tissue Biology, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Diabetologia 52:941-51. 2009
    ..We hypothesised that a combined treatment with a DHA and EPA concentrate (DHA/EPA) and rosiglitazone would correct, by complementary additive mechanisms, impairments of lipid and glucose homeostasis in obesity...
  40. ncbi Autophagy-assisted glycogen catabolism regulates asexual differentiation in Magnaporthe oryzae
    Yi Zhen Deng
    Fungal Patho Biology Group, Temasek Life Sciences Laboratory and Department of Biological Sciences, 1 Research Link, National University of Singapore, Singapore
    Autophagy 5:33-43. 2009
    ..Comparative proteomics based identification and characterization of Gph1, a glycogen phosphorylase that catalyzes glycogen breakdown, indicated that autophagy-assisted glycogen homeostasis is likely ..
  41. ncbi Early postexercise muscle glycogen recovery is enhanced with a carbohydrate-protein supplement
    John L Ivy
    Exercise Physiology and Metabolism Laboratory, Department of Kinesiology and Health Education, University of Texas at Austin, Austin, Texas 78712, USA
    J Appl Physiol 93:1337-44. 2002
    ..that a carbohydrate-protein (CHO-Pro) supplement would be more effective in the replenishment of muscle glycogen after exercise compared with a carbohydrate supplement of equal carbohydrate content (LCHO) or caloric ..
  42. ncbi Training with low muscle glycogen enhances fat metabolism in well-trained cyclists
    Carl J Hulston
    School of Sport and Exercise Sciences, University of Birmingham, Birmingham, United Kingdom
    Med Sci Sports Exerc 42:2046-55. 2010
    To determine the effects of training with low muscle glycogen on exercise performance, substrate metabolism, and skeletal muscle adaptation.
  43. pmc Chronic treatment with the AMP-kinase activator AICAR increases glycogen storage and fatty acid oxidation in skeletal muscles but does not reduce hyperglucagonemia and hyperglycemia in insulin deficient rats
    Kaio F Vitzel
    Muscle Health Research Center School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    PLoS ONE 8:e62190. 2013
    This study tested whether the glycogen-accumulating effect of chronic in vivo pharmacological 5'AMP-activated protein kinase (AMPK) activation could improve glycemic control under conditions of insulin deficiency...
  44. ncbi Freeze tolerance and accumulation of cryoprotectants in the enchytraeid Enchytraeus albidus (Oligochaeta) from Greenland and Europe
    Stine Slotsbo
    National Environmental Research Institute, University of Aarhus, Department of Terrestrial Ecology, Silkeborg, Denmark
    Cryobiology 57:286-91. 2008
    ..When frozen, E. albidus responded by catabolising glycogen to glucose, which likely acted as a cryoprotectant...
  45. pmc The pharmacological chaperone AT2220 increases recombinant human acid α-glucosidase uptake and glycogen reduction in a mouse model of Pompe disease
    Richie Khanna
    Amicus Therapeutics Inc, Cranbury, New Jersey, United States of America
    PLoS ONE 7:e40776. 2012
    ..deficiency in the enzyme acid α-glucosidase (GAA), and is characterized by progressive accumulation of lysosomal glycogen primarily in heart and skeletal muscles...
  46. pmc Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo
    Vincent S Tagliabracci
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 104:19262-6. 2007
    ..Lafora bodies, deposits of abnormally branched, insoluble glycogen-like polymers, form in neurons, muscle, liver, and other tissues...
  47. ncbi Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
    M P Coghlan
    Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Essex, UK
    Chem Biol 7:793-803. 2000
    b>Glycogen synthase kinase-3 (GSK-3) is a serine/threonine protein kinase, the activity of which is inhibited by a variety of extracellular stimuli including insulin, growth factors, cell specification factors and cell adhesion...
  48. ncbi Impaired glycogen synthesis causes metabolic overflow reactions and affects stress responses in the cyanobacterium Synechocystis sp. PCC 6803
    Marianne Gründel
    Humboldt Universitat zu Berlin, Institute of Biology Biochemistry of Plants, Chausseestrasse 117, Berlin, Germany
    Microbiology 158:3032-43. 2012
    The biosynthesis of glycogen or starch is one of the main strategies developed by living organisms for the intracellular storage of carbon and energy...
  49. pmc Glycogen and maltose utilization by Escherichia coli O157:H7 in the mouse intestine
    Shari A Jones
    Advanced Center for Genome Technology, University of Oklahoma, Norman, Oklahoma 73019, USA
    Infect Immun 76:2531-40. 2008
    ..e., maltose, maltodextrin, and glycogen, is important for Escherichia coli colonization of the intestine...
  50. pmc The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor
    Andrew McBride
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Cell Metab 9:23-34. 2009
    AMPK beta subunits contain a conserved domain that causes association with glycogen. Although glycogen availability is known to affect AMPK regulation in vivo, the molecular mechanism for this has not been clear...
  51. ncbi Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen
    Wee Kian Yeo
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia
    Exp Physiol 95:351-8. 2010
    ..programme in which selected high-intensity interval training (HIT) sessions were commenced with low muscle glycogen content increased the maximal activities of several oxidative enzymes that promote endurance adaptations to a ..
  52. pmc High density lipoprotein (HDL) promotes glucose uptake in adipocytes and glycogen synthesis in muscle cells
    Qichun Zhang
    Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing, People s Republic of China
    PLoS ONE 6:e23556. 2011
    ..This investigation was designed to determine the effects and mechanisms of HDL on glucose uptake in adipocytes and glycogen synthesis in muscle cells.
  53. pmc A signalling role for muscle glycogen in the regulation of pace during prolonged exercise
    H G L Rauch
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Sports Science Institute, Boundary Road, Newlands, Cape Town 7700, South Africa
    Br J Sports Med 39:34-8. 2005
    In this study we examined the pacing strategy and the end muscle glycogen contents in eight cyclists, once when they were carbohydrate loaded and once when they were non-loaded.
  54. ncbi Chocolate milk and endurance exercise recovery: protein balance, glycogen, and performance
    William R Lunn
    Exercise Science Department, Southern Connecticut State University, Moore Field House, Room 169, New Haven, CT 06515, USA
    Med Sci Sports Exerc 44:682-91. 2012
    This study examined effects of fat-free chocolate milk (MILK) consumption on kinetic and cellular markers of protein turnover, muscle glycogen, and performance during recovery from endurance exercise.
  55. pmc Molecular mechanism by which AMP-activated protein kinase activation promotes glycogen accumulation in muscle
    Roger W Hunter
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, UK
    Diabetes 60:766-74. 2011
    ..AMPK) promotes glucose transport and glycolysis for ATP production, while it is thought to inhibit anabolic glycogen synthesis by suppressing the activity of glycogen synthase (GS) to maintain the energy balance in muscle...
  56. pmc Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
    Claude Knauf
    UMR 5018, Universite Paul Sabatier, IFR31, Toulouse, France USA
    J Clin Invest 115:3554-63. 2005
    ..of the specific GLP-1 receptor antagonist exendin 9-39 (Ex9) increased muscle glucose utilization and glycogen content...
  57. pmc Toll-like receptor 2 activation by Chlamydia trachomatis is plasmid dependent, and plasmid-responsive chromosomal loci are coordinately regulated in response to glucose limitation by C. trachomatis but not by C. muridarum
    CATHERINE M O'CONNELL
    Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Infect Immun 79:1044-56. 2011
    ..muridarum. As observed with plasmid-deficient C. muridarum, CTD153 displayed impaired accumulation of glycogen within inclusions...
  58. pmc Crystal structure of full-length Mycobacterium tuberculosis H37Rv glycogen branching enzyme: insights of N-terminal beta-sandwich in substrate specificity and enzymatic activity
    Kuntal Pal
    Department of Biological Sciences, National University of Singapore, Singapore 117543
    J Biol Chem 285:20897-903. 2010
    ..We have assayed the amylase activity with amylose and starch as substrates and the glycogen branching activity using amylose as a substrate for MtbGlgBWT and the N1 domain-deleted (the first 108 residues ..
  59. pmc Autophagy and mitochondria in Pompe disease: nothing is so new as what has long been forgotten
    Nina Raben
    NIAMS, NIH, Bethesda, MD 20892 1820, USA
    Am J Med Genet C Semin Med Genet 160:13-21. 2012
    ..recent data provide strong evidence for the role of autophagy in the pathogenesis of Pompe disease, a lysosomal glycogen storage disease caused by deficiency of acid alpha-glucosidase (GAA)...
  60. pmc Roles of two protein phosphatases, Reg1-Glc7 and Sit4, and glycogen synthesis in regulation of SNF1 protein kinase
    Amparo Ruiz
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 108:6349-54. 2011
    ..The SNF1 β-subunit contains a glycogen-binding domain that has been implicated in glucose inhibition of Snf1 Thr210 phosphorylation...
  61. ncbi Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?
    S Patel
    Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Biochem Soc Trans 32:803-8. 2004
    b>Glycogen synthase kinase-3 is an unusual protein serine/threonine kinase that, unlike most of its 500-odd relatives in the genome, is active under resting conditions and is inactivated upon cell stimulation...
  62. ncbi Inhibition of glycogenolysis in astrocytes interrupts memory consolidation in young chickens
    Marie E Gibbs
    Department of Anatomy and Cell Biology, Monash University, Clayton, Australia
    Glia 54:214-22. 2006
    ..glycolysis; however, the metabolic inhibitor used, iodoacetate, inhibits pyruvate formation from both glucose and glycogen. At specific time points after training transient reductions in brain glycogen content occur, mirrored by ..
  63. pmc The NDR kinase DBF-2 is involved in regulation of mitosis, conidial development, and glycogen metabolism in Neurospora crassa
    Efrat Dvash
    Department of Plant Pathology and Microbiology, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    Eukaryot Cell 9:502-13. 2010
    ..demonstrate that DBF-2 is involved in three fundamental processes in a filamentous fungus: cell cycle regulation, glycogen biosynthesis, and conidiation...
  64. pmc PCB 126 and other dioxin-like PCBs specifically suppress hepatic PEPCK expression via the aryl hydrocarbon receptor
    Wenshuo Zhang
    Department of Medicine, Kovler Center for Biomedical Discovery, The University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e37103. 2012
    ..Overnight treatment with PCB 126 reduced hepatic glycogen stores in a dose-dependent manner...
  65. pmc The imprinted Phlda2 gene regulates extraembryonic energy stores
    S J Tunster
    Genetics Division, Cardiff School of Biosciences, Cardiff University, Cardiff, Wales CF10 3AX, United Kingdom
    Mol Cell Biol 30:295-306. 2010
    ..of the imprinted Phlda2 gene characterized by a dramatically reduced junctional zone and a decrease in stored glycogen. In addition, glycogen cells do not migrate into the maternal decidua in a timely fashion, but instead, Tpbpa-..
  66. ncbi Photoperiodic regulation of glycogen metabolism, glycolysis, and glutamine synthesis in tanycytes of the Siberian hamster suggests novel roles of tanycytes in hypothalamic function
    Kanishka Nilaweera
    Rowett Institute for Nutrition and Health, University of Aberdeen, Aberdeen, United Kingdom
    Glia 59:1695-705. 2011
    ..This analysis revealed upregulation in expression of genes involved in glycogen and glucose metabolism in short photoperiod and localized to the tanycyte layer of the third ventricle...
  67. ncbi Regulation of glycogen synthase activity and phosphorylation by exercise
    Jakob N Nielsen
    Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Proc Nutr Soc 63:233-7. 2004
    b>Glycogen synthase (GS) catalyses the rate-limiting step of UDP-glucose incorporation into glycogen...
  68. pmc Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: Identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1
    Sixin Jiang
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 413:420-5. 2011
    b>Glycogen, a branched polymer of glucose, acts as an intracellular carbon and energy reserve in many tissues and cell types. An important pathway for its degradation is by transport to lysosomes in an autophagy-like process...
  69. ncbi Resveratrol ameliorates diabetes-related metabolic changes via activation of AMP-activated protein kinase and its downstream targets in db/db mice
    Gyeong Min Do
    Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Republic of Korea
    Mol Nutr Food Res 56:1282-91. 2012
    ..This study investigated the effects of resveratrol (RV) on diabetes-related metabolic changes in a spontaneous model of type 2 diabetes, as well as activation of AMP-activated protein kinase (AMPK) and downstream targets...
  70. ncbi Quantifying hepatic glycogen synthesis by direct and indirect pathways in rats under normal ad libitum feeding conditions
    Ana F Soares
    Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal
    Magn Reson Med 61:1-5. 2009
    Hepatic glycogen synthesis from intact hexose (direct pathway) relative to that from gluconeogenic precursors (indirect pathway) was quantified in ad libitum-fed rats...
  71. ncbi Neuron-glia metabolic coupling and plasticity
    Pierre J Magistretti
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Switzerland and Centre de Neurosciences Psychiatriques, CHUV, Departement de Psychiatrie, Site de Cery, CH1008 Prilly Lausanne, Switzerland
    J Exp Biol 209:2304-11. 2006
    ..In addition, marked variations in the expression of genes involved in glial glycogen metabolism are observed during the sleep-wake cycle, with in particular a marked induction of expression of the ..
  72. pmc PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance
    Sean M Crosson
    Department of Medicine, Life Sciences Institute, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 0650, USA
    J Clin Invest 111:1423-32. 2003
    Protein targeting to glycogen (PTG) is a scaffolding protein that targets protein phosphatase 1alpha (PP1alpha) to glycogen, and links it to enzymes involved in glycogen synthesis and degradation...
  73. ncbi Glycogen hyperphosphorylation underlies lafora body formation
    Julie Turnbull
    Department of Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Neurol 68:925-33. 2010
    b>Glycogen, the largest cytosolic macromolecule, acquires solubility, essential to its function, through extreme branching. Lafora bodies are aggregates of polyglucosan, a long, linear, poorly branched, and insoluble form of glycogen...
  74. pmc AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTG-protein phosphatase 1 holoenzyme, and accelerates its down-regulation by the laforin-malin complex
    Santiago Vernia
    Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas CSIC and CIBER de Enfermedades Raras CIBERER, Jaime Roig 11, Valencia 46010, Spain
    J Biol Chem 284:8247-55. 2009
    R5/PTG is one of the glycogen targeting subunits of type 1 protein phosphatase, a master regulator of glycogen synthesis...
  75. ncbi Postexercise muscle glycogen recovery enhanced with a carbohydrate-protein supplement
    John M Berardi
    Exercise Nutrition Research Laboratory, Faculty of Health Sciences, School of Kinesiology, The University of Western Ontario, Ontario, Canada
    Med Sci Sports Exerc 38:1106-13. 2006
    ..assessed whether liquid carbohydrate-protein (C+P) supplements, ingested early during recovery, enhance muscle glycogen resynthesis versus isoenergetic liquid carbohydrate (CHO) supplements, given early or an isoenergetic solid meal ..
  76. pmc Last step in the conversion of trehalose to glycogen: a mycobacterial enzyme that transfers maltose from maltose 1-phosphate to glycogen
    Alan D Elbein
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 285:9803-12. 2010
    ..show that Mycobacterium smegmatis has an enzyme catalyzing transfer of maltose from [(14)C]maltose 1-phosphate to glycogen. This enzyme was purified 90-fold from crude extracts and characterized...
  77. pmc Effects of larval growth condition and water availability on desiccation resistance and its physiological basis in adult Anopheles gambiae sensu stricto
    Fred Aboagye-Antwi
    Centre for Applied Entomology and Parasitology, School of Life Sciences, Keele University, Keele, Staffordshire, UK
    Malar J 9:225. 2010
    ..Natural populations of the malaria mosquito Anopheles gambiae s.s. are exposed to large seasonal and daily fluctuations in relative humidity and temperature, which makes coping with drought a crucial aspect of their ecology...
  78. pmc Regulation of glucose and glycogen metabolism during and after exercise
    Thomas E Jensen
    Molecular Physiology Group, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    J Physiol 590:1069-76. 2012
    Utilization of carbohydrate in the form of intramuscular glycogen stores and glucose delivered from plasma becomes an increasingly important energy substrate to the working muscle with increasing exercise intensity...
  79. ncbi Potential mechanism(s) involved in the regulation of glycogen synthesis by insulin
    A K Srivastava
    Research Center, CHUM, Hotel Dieu Campus, Montreal, Quebec, Canada
    Mol Cell Biochem 182:135-41. 1998
    Stimulation of glycogen synthesis is one of the major physiological responses modulated by insulin...
  80. pmc Molecular analysis of GPH1, the gene encoding glycogen phosphorylase in Saccharomyces cerevisiae
    P K Hwang
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0448
    Mol Cell Biol 9:1659-66. 1989
    In yeast cells, the activity of glycogen phosphorylase is regulated by cyclic AMP-mediated phosphorylation of the enzyme. We have previously cloned the gene for glycogen phosphorylase (GPH1) in Saccharomyces cerevisiae...
  81. pmc ADP-glucose pyrophosphorylase, a regulatory enzyme for bacterial glycogen synthesis
    Miguel A Ballicora
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Microbiol Mol Biol Rev 67:213-25, table of contents. 2003
    ..In bacteria and plants, the synthesis of glycogen and starch occurs by utilizing ADP-glucose as the glucosyl donor for elongation of the alpha-1,4-glucosidic chain...
  82. ncbi Immunocytochemical localization of glycogen phosphorylase isozymes in rat nervous tissues by using isozyme-specific antibodies
    Brigitte Pfeiffer-Guglielmi
    Physiologisch Chemisches Institut der Universität and Institut für Organische Chemie der Universität, Tubingen, Germany
    J Neurochem 85:73-81. 2003
    Isozyme-specific antibodies were raised against peptides from the low-homology regions of the sequences of rat glycogen phosphorylase BB and MM isozymes by immunization of rabbits and guinea pigs...
  83. pmc MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST)
    Peter C M van Zijl
    Division of Magnetic Resonance Research, Neurology Section, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:4359-64. 2007
    Detection of glycogen in vivo would have utility in the study of normal physiology and many disorders...
  84. ncbi Glycogen branches out: new perspectives on the role of glycogen metabolism in the integration of metabolic pathways
    Cynthia C Greenberg
    Department of Medicine, Committee on Molecular Metabolism and Nutrition, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Endocrinol Metab 291:E1-8. 2006
    b>Glycogen is the storage form of carbohydrate for virtually every organism from yeast to primates. Most mammalian tissues store glucose as glycogen, with the major depots located in muscle and liver...
  85. pmc Gain-of-function R225W mutation in human AMPKgamma(3) causing increased glycogen and decreased triglyceride in skeletal muscle
    Sheila R Costford
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 2:e903. 2007
    ..Here we report the first gain-of-function mutation in the muscle-specific regulatory gamma(3) subunit in humans...
  86. pmc The Saccharomyces SHP1 gene, which encodes a regulator of phosphoprotein phosphatase 1 with differential effects on glycogen metabolism, meiotic differentiation, and mitotic cell cycle progression
    S Zhang
    Department of Microbiology and Immunology, State University of New York Health Science Center at Brooklyn 11203 2098
    Mol Cell Biol 15:2037-50. 1995
    ..phosphatase 1 (PP1) catalytic subunit encoded by the Saccharomyces GLC7 gene is involved in control of glycogen metabolism, meiosis, translation, chromosome segregation, cell polarity, and G2/M cell cycle progression...
  87. ncbi A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle
    D Milan
    Laboratoire de Genetique Cellulaire, Institut National de la Recherche Agronomique INRA, 31326 Castanet Tolosan, France
    Science 288:1248-51. 2000
    A high proportion of purebred Hampshire pigs carries the dominant RN- mutation, which causes high glycogen content in skeletal muscle. The mutation has beneficial effects on meat content but detrimental effects on processing yield...
  88. ncbi Selective suppression of AMP-activated protein kinase in skeletal muscle: update on 'lazy mice'
    J Mu
    Department of Medicine, Howard Hughes Medical Institute, University of Pennsylvania Medical School, Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104 6148, USA
    Biochem Soc Trans 31:236-41. 2003
    ..These same mice could not maintain sufficient glycogen in their skeletal muscle and it was rapidly depleted when the animals were subjected to mild exercise...
  89. pmc Conditional essentiality of the csrA gene in Escherichia coli
    Johan Timmermans
    Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Gosselies, Belgium
    J Bacteriol 191:1722-4. 2009
    ..Deletion of the glgCAP operon in the csrA::cat mutant restored the ability to grow on LB and on synthetic medium containing glycolytic carbon sources, showing that growth inhibition is due to an excess of glycogen synthesis.
  90. pmc Glycogen synthase localization and activity in rat skeletal muscle is strongly dependent on glycogen content
    J N Nielsen
    Copenhagen Muscle Research Centre, Department of Human Physiology, University of Copenhagen, Denmark
    J Physiol 531:757-69. 2001
    1. The influence of muscle glycogen content on glycogen synthase (GS) localization and GS activity was investigated in skeletal muscle from male Wistar rats. 2...
  91. ncbi The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle
    Brian R Barnes
    Department of Surgical Sciences and the Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Biol Chem 279:38441-7. 2004
    ..missense mutation (R225Q) in pig PRKAG3, encoding the muscle-specific gamma3 isoform, causes a marked increase in glycogen content...
  92. ncbi Recombinant human acid alpha-glucosidase enzyme therapy for infantile glycogen storage disease type II: results of a phase I/II clinical trial
    A Amalfitano
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Genet Med 3:132-8. 2001
    PURPOSE: Infantile glycogen storage disease type II (GSD-II) is a fatal genetic muscle disorder caused by deficiency of acid alpha-glucosidase (GAA)...
  93. ncbi Control of glucose utilization in working perfused rat heart
    Y Kashiwaya
    National Institute on Alcoholism and Alcohol Abuse, Rockville, Maryland 20895
    J Biol Chem 269:25502-14. 1994
    ..05 unit/ml), or both. Net glycogen breakdown occurred in the glucose group only and was converted to net glycogen synthesis in the presence of all ..
  94. ncbi Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle
    Jorgen F P Wojtaszewski
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 284:E813-22. 2003
    ..The experiment was performed twice, once in a glycogen-loaded (glycogen concentration approximately 900 mmol/kg dry wt) and once in a glycogen-depleted (glycogen ..
  95. ncbi Generalized glycogen storage and cardiomegaly in a knockout mouse model of Pompe disease
    A G Bijvoet
    Department of Clinical Genetics, Erasmus University, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Hum Mol Genet 7:53-62. 1998
    b>Glycogen storage disease type II (GSDII; Pompe disease), caused by inherited deficiency of acid alpha-glucosidase, is a lysosomal disorder affecting heart and skeletal muscles...
  96. ncbi Catalytic isoforms Tpk1 and Tpk2 of Candida albicans PKA have non-redundant roles in stress response and glycogen storage
    Romina Giacometti
    Catedra de Microbiologia, Facultad de Agronomia, Universidad de Buenos Aires, IBYF CONICET, Avda San Martin 4453, C1417DSE Buenos Aires, Argentina
    Yeast 26:273-85. 2009
    ..albicans PKA in response to saline, heat and oxidative stresses as well as in glycogen storage. To fine-tune the analysis, we performed the studies on several C...
  97. ncbi The genotype-phenotype correlation in Pompe disease
    Marian Kroos
    Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Am J Med Genet C Semin Med Genet 160:59-68. 2012
    Pompe disease is an autosomal recessive lysosomal glycogen storage disorder that is caused by acid α-glucosidase (GAA) deficiency and is due to pathogenic sequence variations in the corresponding GAA gene...
  98. ncbi Role of insulin on exercise-induced GLUT-4 protein expression and glycogen supercompensation in rat skeletal muscle
    Chia Hua Kuo
    Department of Kinesiology and Health Education, University of Texas at Austin, Austin, Texas 78712, USA
    J Appl Physiol 96:621-7. 2004
    The purpose of this study was to investigate the role of insulin on skeletal muscle GLUT-4 protein expression and glycogen storage after postexercise carbohydrate supplementation...
  99. ncbi Physiological and biochemical changes in summer and winter diapause and non-diapause pupae of the cabbage armyworm, Mamestra brassicae L. during long-term cold acclimation
    Lei Ding
    Faculty of Agriculture, Department of Bioprocess Engineering, Yamagata University, Tsuruoka 997 8555, Japan
    J Insect Physiol 49:1153-9. 2003
    ..During cold acclimation, glycogen content remained at higher levels in WD and SD than in ND...
  100. ncbi Determinants of the nucleocytoplasmic shuttling of muscle glycogen synthase
    Emili Cid
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Spain
    FEBS J 272:3197-213. 2005
    Muscle glycogen synthase (MGS) presents a nuclear speckled pattern in primary cultured human muscle and in 3T3-L1 cells deprived of glucose and with depleted glycogen reserves...
  101. ncbi Placental glycogen stores are increased in mice with H19 null mutations but not in those with insulin or IGF type 1 receptor mutations
    Diego R Esquiliano
    Endocrine Division, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Placenta 30:693-9. 2009
    The function of glycogen in the placenta remains controversial. Whether it is used as a source of fuel for placental consumption or by the fetus in times of need has yet to be determined...

Research Grants73

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..eNOS) and 5'-adenosine monophosphate-activated protein kinase (AMPK), and enhances glucose disposal and glycogen storage by preventing desensitization of adrenergic receptor actions via suppression of insulin clearance and by ..
  3. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
    ..2) Identify metabolic signals (e.g., NADH/NAD, glycogen, fatty acid oxidation products) associated with effective IF regimens...
  4. Genetic and physiological causes of inherited Vascular and Metabolic Diseases
    Arya Mani; Fiscal Year: 2013
    ..The mechanisms of insulin resistance caused by LRP6 mutation are not known. Defect in glycogen synthesis of the skeletal muscle is thought to be one of the major causes of insulin resistance...
  5. Molecular Regulation of Progesterone Synthesis
    John S Davis; Fiscal Year: 2013
    ..test the overall hypothesis that activation of protein kinase A inhibits the intracellular signaling intermediate glycogen synthase kinase 3 (GSK3), which contributes to the steroidogenic response to LH by increasing the availability of ..
  6. New insights in mechanisms of renal injury
    Balakuntalam S Kasinath; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Our objective is to investigate the role of glycogen synthase kinase 3beta (GSK 3beta) in diabetic nephropathy. The rationale is based on our preliminary data: 1...
  7. Regulation of myocardial growth and death by GSK-3
    Junichi Sadoshima; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glycogen synthase kinase-3 (GSK-3), a serine/threonine kinase, plays an important role in regulating growth and death of cardiomyocytes...
  8. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
    ..that stimulates the serine/threonine kinase Akt2, leading to increased glucose uptake, glucose oxidation and glycogen synthesis. Insulin- stimulated Akt2 activation also may result in altered lipid metabolism...
  9. ER stress: role in myocyte apoptosis and myocardial remodeling
    Krishna Singh; Fiscal Year: 2013
    ..Recently, we provided evidence that activation of glycogen synthase kinase-32 (GSK-32) plays a pro-apoptotic role in 2-AR- stimulated apoptosis via the involvement of ..
  10. The genetics and pathophysiology of impaired Wnt signaling in metabolic syndrome
    Arya Mani; Fiscal Year: 2012
    ..knockout mice on Western diet has demonstrated increased glucose stimulated insulin levels and reduced hepatic glycogen content...
  11. Extracellular ubiquitin: role in myocyte apoptosis and myocardial remodeling
    Krishna Singh; Fiscal Year: 2010
    ..We have shown that ?-AR-stimulated apoptosis is mediated via the activation of glycogen synthase kinase-3? (GSK-3?) and JNK-dependent mitochondrial death pathway in adult rat ventricular myocytes (..
  12. Cell stress, development, and stimulant-induced behavior: Regulation by GSK3
    Marjelo A Mines; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Glycogen synthase kinase-3 (GSK3) has widespread regulatory effects on cell signaling pathways and behavioral phenotypes associated with psychiatric diseases...
  13. Neuroprotection by IFN-beta in AIDS
    Marcus Kaul; Fiscal Year: 2013
    ..IFN? induces neuroprotective ?-chemokines and NGF, increases activity of Akt, reduces activity of p38 MAPK and glycogen synthase kinase (GSK) 32 and hyperphosphorylation of tau, and thus protects neurons and their dendrites and ..
  14. Molecular Pathological Mechanism & Potential Therapeutics of Lafora Disease
    YAN NONE LIU; Fiscal Year: 2010
    ..of progressive myoclonus epilepsy (PME), severe neurological deterioration, and the accumulation of starch-like glycogen inclusion bodies (LB) mainly in the brain, muscle, and liver...
  15. Role of Matrix Metalloproteinase-1 in Endothelial Cell Senescence
    Catherine D Mao; Fiscal Year: 2010
    ..used to treat bipolar disorder as well as to activate the oncogenic 2-catenin signaling pathway via inhibition of glycogen synthase kinase (GSK)-32...
  16. Mechanisms of Airway Smooth Muscle Hypertrophy
    Marc B Hershenson; Fiscal Year: 2013
    ..expression on neonatal lung mesenchymal stromal cell proliferation and differentiation, as well as the roles of glycogen synthase kinase (GSK)-3[unreadable] and [unreadable]-catenin in myofibroblastic differentiation in vitro...
  17. Interactions Between Depression, Neuroinflammation and Glycogen Synthase Kinase-3
    Eleonore Beurel; Fiscal Year: 2011
    ..b>Glycogen synthase kinase-3 (GSK3) recently was found to be a powerful regulator of cytokine production in the periphery...
  18. INSULIN ACTION IN MUSCLE AND FAT CELLS
    JAMES CARLTON GARRISON; Fiscal Year: 2010
    ..Glucose transport and oxidation, lipid and glycogen synthesis, GLUT4 translocation, and several parameters of insulin signaling will be measured after increasing or ..
  19. Cannabinoid regulation of glycogen synthase kinase-3
    Cecilia J Hillard; Fiscal Year: 2013
    ..b>Glycogen synthase kinase 3 (GSK-3) is emerging as an important regulatory kinase in the limbic brain;over-activity of GSK-..
  20. Glutamate-Glutamine Metabolism in Primary Human Brain Tumors
    Anne Williamson; Fiscal Year: 2010
    ..2, we propose that changing the fuel balance to one favoring fatty acids and ketone bodies with reduced glucose/glycogen availability will reduce extracellular glutamate release by increasing glutamate oxidation and thus reducing the ..
  21. Gluconeogenesis and Glycogenolysis - Role and Regulation
    Alan D Cherrington; Fiscal Year: 2013
    ..and its indirect effects mediated by insulin acton in the brain, 2) to determine the mechanism by which liver glycogen loading enhances the hormonal response to insulin induced hypoglycemia, and 3) to determine the physiologic basis ..
  22. GSK3beta, a mediator of ethanol neurotoxicity
    Xianglin Shi; Fiscal Year: 2013
    ..The loss of CNS neurons may underlie many of the behavioral deficits observed in FASD. Glycogen synthase kinase 3[unreadable] (GSK3[unreadable]), a serine/threonine kinase, is an important mediator of neuron ..
  23. Adipose Stem Cell Therapy for Krabbe Disease
    Bruce Bunnell; Fiscal Year: 2009
    Krabbe's disease is a life threatening, inherited glycogen storage disease resulting from mutations in the enzyme galactocerebrosidase (GALC)...
  24. SECRETION AND BIOSYNTHESIS OF INSULIN
    Michael L McDaniel; Fiscal Year: 2012
    ..Recent studies have determined that inhibition of glycogen synthase kinase-3 (GSK-3) &tuberous sclerosis complex 2 (TSC2) are required for mTOR activation...
  25. ELEVATED CALCIUM AND MYOCARDIAL ISCHEMIC INJURY
    Charles Steenbergen; Fiscal Year: 2013
    ..b>Glycogen Synthase Kinase-32 (GSK-32) is also implicated as a critical element in many cardioprotective pathways...
  26. Transcriptional Regulation of Metabolic and Hepatic Homeostasis by FoxO Signaling
    Shaodong Guo; Fiscal Year: 2013
    ..In the fasting liver, glucagon stimulates gluconeogenesis, degrades macromolecules including glycogen, lipid, and protein, and promotes the autophagic pathway that regulates cellular organelle turnover...
  27. Interactions Between Depression, Neuroinflammation and Glycogen Synthase Kinase-3
    Eleonore Beurel; Fiscal Year: 2013
    ..b>Glycogen synthase kinase-3 (GSK3) recently was found to be a powerful regulator of cytokine production in the periphery...
  28. GSK3: immunoregulator in experimental autoimmune encephalomyelitis (EAE)
    Patrizia De Sarno; Fiscal Year: 2012
    ..Other cell types involved in the disease are dendritic cells, macrophages, and microglia. The enzyme glycogen synthase kinase-3 (GSK3) is a critical regulator of a variety of cellular functions, and we and others now report ..
  29. Control of Breathing and Pompe Disease
    David D Fuller; Fiscal Year: 2013
    ..resulting from mutations in the gene for acid ?-glucosidase (GAA) - an enzyme necessary to degrade lysosomal glycogen. Hypoventilation is a hallmark feature of Pompe disease and work from the first cycle of this grant demonstrated ..
  30. Mechanisms of Fatty-Acid Inhibition of the Insulin Gene
    Vincent Poitout; Fiscal Year: 2013
    ..Our working hypothesis is that PASK phosphorylates, and thereby inactivates, glycogen synthase kinase (GSK) 3[unreadable] which alleviates proteasomal degradation of Pdx-1 and MafA...
  31. Targeting stress-mediated pathways in the treatment of muscle insulin resistance
    Paige C Geiger; Fiscal Year: 2013
    ..In Specific Aim 2, we will determine the extent to which glycogen synthase kinase-3 (GSK-3) and JNK signaling pathways modulate HSP expression in insulin-resistant skeletal muscle...
  32. Regulation of Hepatic Carbohydrate Metabolism by STBD1
    Alan Cheng; Fiscal Year: 2012
    ..In skeletal and cardiac muscle, insulin stimulates glycogen accumulation through a coordinate increase in glucose transport and regulation of glycogen metabolizing enzymes, ..
  33. The Role of HIF-1 in Neurogenic and Behavior Responses to Antidepressants.
    W TIMOTHY O'BRIEN; Fiscal Year: 2013
    ..It is a noteworthy coincidence that inhibition of glycogen synthase kinase-3 (GSK-3) is a common molecular consequence of treatment with diverse classes of antidepressants ..
  34. The role of phosphorylation of Ulk1 by GSK-3b in myocardial autophagy and aging
    Peiyong Zhai; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glycogen syntheses kinase-3b (GSK-3b) is a ubiquitously expressed serine/heroine protein kinase that has multiple functions in cells, including growth, death and metabolism...
  35. Novel Model Systems Link Floridean Starch Metabolism to Lafora Disease
    Matthew S Gentry; Fiscal Year: 2010
    ..how laforin, the only phosphatase in Kingdom Animalia with a carbohydrate binding domain, regulates changes in glycogen metabolism in vertebrates and invertebrates...
  36. Fundamental mechanisms of protein kinase activation loop autophosphorlyation
    Vaughn Cleghon; Fiscal Year: 2013
    ..DYRKs and glycogen synthase kinase 3 (GSK3) enzymes are dual-specificity kinases that autophosphorylate their activation loop on an ..
  37. Cytochrome P4501B1 and basal liver PPARa activity
    COLIN ROBERT JEFCOATE; Fiscal Year: 2013
    ..serum extracts will focus on establishing that Cyp1b1 deletion increases mitochondrial fatty acid oxidation and glycogen synthesis, while lowering oxidative stress...
  38. Interstitial Cells of Cajal in Diabetic Gastropathy
    TAMAS ORDOG; Fiscal Year: 2013
    ..Our second specific aim is to determine the role and molecular mechanisms-of-action of glycogen synthase kinase 3 (Gsk3) as an extrinsic factor in regulating ICC-SC through stem cell factor expression in ..
  39. Imaging Biomarkers for Evaluating Mitochondrial Function in Diabetes
    Geoffrey David Clarke; Fiscal Year: 2013
    ..that affects liver, muscle and fat tissue by stimulating glucose uptake from blood and promoting its storage as glycogen in liver and muscle...
  40. The role of inflammatory cytokines in the regulation of hepatic insulin signaling
    Daniel Okin; Fiscal Year: 2013
    ..and in vivo] chronic TNF? on [hepatocyte insulin-signaling and functional response including gluconeogenesis, glycogen synthesis, and lip genesis]...
  41. Microtubule dynamics during cell polarity and migration
    Torsten Wittmann; Fiscal Year: 2012
    ..This association of CLASPs along lamella microtubules is decreased through phosphorylation by glycogen synthase kinase 3? (GSK3?), an emerging integrator of cell polarity pathways...
  42. Discovery of Novel Antitumor Agents Effective Against Pancreatic Cancer
    Amy E Wright; Fiscal Year: 2012
    ..Our initial targets will be: the serine/threonine glycogen synthase kinase-32 (GSK-32) which has been shown to activate nuclear factor-kB (NF-kB) transcription in ..
  43. An investigation of the mechanisms by which down-regulation of lipoprotein lipase
    Jheem D Medh; Fiscal Year: 2013
    ..insulin-regulated metabolic pathways including the oxidation and synthesis of fatty acids, and the synthesis of glycogen. In addition to its lipolytic function, LPL is also a ligand for lipoprotein receptors, This is an additional ..
  44. Functional Characterization of CCDC130 Gene
    Deepak Kumar; Fiscal Year: 2012
    ..protein (b) induced by Insulin-like growth factor (IGF-1)/insulin signaling (c) a putative target for Glycogen Synthase Kinase (GSK-3), Casein kinase 1 (CK1) and Casein kinase 2 (CK2) (d) down regulated in colon cancer and (..
  45. Vaginal microbiota, immune responses and vulvovaginal symptoms during menopause
    Rebecca M Brotman; Fiscal Year: 2013
    ..women approach menopause, decreased estrogen levels are accompanied by changes in the vagina including decreased glycogen accumulation in the epithelium, increased pH, and deterioration of vaginal tissues, which lead to symptoms of ..
  46. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    Scot R Kimball; Fiscal Year: 2010
    ..The second is the phosphorylation of elF2Be through activation of glycogen synthase kinase-3p (GSKSfi)...
  47. Signaling pathways regulated by GSK3 in hematopoietic stem cell
    Jian Huang; Fiscal Year: 2012
    ..The signaling pathways that regulate HSC self-renewal and differentiation are not well understood. Glycogen synthase kinase-3 (GSK3), a negative regulator of canonical Wnt signaling and a downstream target of ..
  48. MULTI-TISSUE MULTI-TRACER METABOLIC PHENOTYPING OF DIABETES WITH PRE-CLINICAL PET
    KOORESH ISAAC SHOGHI; Fiscal Year: 2013
    ..and triglycerides synthesis (storage), 18FTHA for fatty acid oxidation;[11C]Glucose for glucose oxidation and glycogen synthesis, 18FDG for glucose utilization, and [11C]Lactate as a potential imaging marker for gluconeogenesis...
  49. Mechanism of Gli3 processing in Hedgehog signaling
    Baolin Wang; Fiscal Year: 2013
    ..Gli3 processing requires C-terminal phosphorylation by protein kinase A (PKA), glycogen synthase kinase 3 (GSK3), and casein kinase 1 (CK1), and subsequent ubiquitination by SCFTrCP E3 ubiquitin ligase...
  50. Suicide Endophenotypes and Molecular Mechanisms of Lithium Action
    Todd D Gould; Fiscal Year: 2013
    ..studies indicate that lithium may exert some of its mood stabilizing effects through inhibition of the enzyme glycogen synthase kinase-3! (GSK-3!)...
  51. Postnatal Serotonin Deficits in Behavioral Pathogenesis: A Novel Genetic Approach
    MEREDITH SORENSON WHITNEY; Fiscal Year: 2013
    ..the effect of postnatal 5-HT deficiency on two post-synaptic mechanisms involved in 5-HT-related behaviors, glycogen synthase kinase-[unreadable] (GSK3 [unreadable]) signaling and glucocorticoid receptor expression...
  52. Molecular mechanisms of Myotonic Dystrophy 1
    Lubov T Timchenko; Fiscal Year: 2012
    ..Searching for the mechanisms of the reduction of cyclin D3 in DM1, we found that the active glycogen synthase kinase 3? (GSK3?) is increased in DM1 muscle biopsies and in muscle of the DM1 mouse model (HSALR mice)...
  53. A Kinase-Substrate Crosslinker For Mapping Signaling Pathways in Reverse
    Kevan M Shokat; Fiscal Year: 2012
    ..We propose to identify the kinases which phosphorylate Glycogen Synthase Kinase- 32 (GSK-32) at it's inhibitory Ser-9 residue, a subject of much study and debate in ..
  54. Regulation of Renal Response to Vasopressin by Glycogen Synthase
    Reena Rao; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glycogen synthase kinase 3 (GSK3) is a family of serine/threonine protein kinases that consists of two isoforms, GSK3a and GSK3[unreadable]...
  55. Regulation of energy balance in Drosophila
    John B Thomas; Fiscal Year: 2012
    ..dTORC mutant flies are sensitive to starvation and have significantly lower glycogen and lipid stores compared to wild type...
  56. REGULATION OF HEPATIC AND PERIPHERAL GLUCOSE METABOLISM
    Ralph A DeFronzo; Fiscal Year: 2013
    ..examine the effect of sustained hyperglycemia (+25 mg/dl) on whole body insulin sensitivity, insulin signaling, glycogen synthesis, glucose oxidation, and mitochondria function...
  57. Targeting Hexokinase II in Chemotherapy
    John G Pastorino; Fiscal Year: 2012
    ..The localization of HXK II to mitochondria is controlled in part by the activity of the PBR and glycogen synthase kinase 3P (GSKP)...
  58. STEROID CONTROL OF EPITHELIAL CELL-CELL INTERACTIONS
    Gary L Firestone; Fiscal Year: 2011
    ..is to test the hypothesis that the functional coordination of ubiquitin-proteasome mediated degradation of GSK3 (Glycogen Synthase Kinase-3), a multifunctional serine/threonine kinase, and of CAS (Cellular Apoptosis Susceptibility gene)..
  59. Liver Glucose Flux in Obesity and Diabetes
    Masakazu Shiota; Fiscal Year: 2013
    ..to hyperglycemia with a failure to suppress net hepatic glucose production and increase glucose hepatic flux to glycogen associated with a failure to accelerate glucokinase (GK) catalyzed glucose phosphorylation...
  60. The distinct roles of AMPK in neurons and astrocytes following stroke
    Jun Li; Fiscal Year: 2013
    ..gene expression, reducing energy storage and increasing energy production (glycolysis, fatty acid oxidation and glycogen utilization)...
  61. GLUT8 Overexpression in Cardioprotection
    Maureen J Charron; Fiscal Year: 2010
    ..hearts that unexpectedly take up more than normal amounts of glucose and exhibit increased glycolysis and glycogen synthesis...
  62. Regulating Hematopoietic Stem Cell Homeostasis through GSK-3
    Wei Tong; Fiscal Year: 2013
    ..b>Glycogen synthase kinase-3 (GSK-3) negatively regulates multiple signaling pathways in hematopoiesis, including Wnt ..
  63. DiosMemTM, a natural gamma-secretase inhibitor, opposes AD pathogenesis
    Jun Tan; Fiscal Year: 2009
    ..Among the many promising potential candidates are the glycogen synthase kinase 3 (GSK-3) inhibitors...
  64. Glycogen synthase kinase-3beta: a setpoint for dopamine dysfunction in neuroAIDS
    Seth Perry; Fiscal Year: 2009
    ..Separately, we have found significant roles for glycogen kinase three-beta (GSK-3beta) in models of HAND, and others'have implicated GSK-3beta in controlling alpha-..
  65. Liver Glycogen in Control of Plasma Glucose
    Katarina Borer; Fiscal Year: 2009
    ..We hypothesize that inadequate hepatic glycogen recovery due to preferential muscle glucose uptake during and after exercise is responsible for EAAF and is ..
  66. GLUCONEOGENESIS & DE NOVO LIPOGENESIS IN CYSTIC FIBROSIS
    DANA HARDIN; Fiscal Year: 2000
    ..We recently reported significantly lower rates of glucose oxidation (glycogen storage) during hyperinsulinemia in CF subjects...
  67. SUBCELLULAR EFFECTS OF METABOLIC HORMONES ON RAT LIVER
    ROBERT CARDELL; Fiscal Year: 1991
    ..in this application is to provide new morphological information related to subcellular mechanisms of hepatic glycogen metabolism through the use of light and electron microscopy autoradiographs and immunocytochemistry using ..
  68. GLYCOGEN METABOLISM AND SIGNAL TRANSDUCTION IN YEAST
    Peter Roach; Fiscal Year: 2005
    ..signal transduction in the yeast Saccharomyces cerevisiae by analysis of the nutritional controls that govern glycogen storage...
  69. Insulin and Oocyte Chromatin Segregation
    Gary Smith; Fiscal Year: 2009
    ..Insulin's terminal signaling enzyme is glycogen synthase kinase-3 (GSK-3)...
  70. INBORN ERRORS OF CARBOHYDRATE METABOLISM
    HENRI GERY HERS; Fiscal Year: 1991
    ..glucokinase, a further investigation of the role of fructose 2,6-bisphosphate in biology and various aspects of glycogen metabolism. We will also try to detect inborn errors of metabolism related to each of these specific subjects...
  71. Carbohydrate Metabolic Pathways
    Faramarz Ismail Beigi; Fiscal Year: 2007
    ..3) To quantitate simultaneous hepatic glycogen synthesis and breakdown, i.e. cycling in type 2 diabetes...
  72. Effect of hepatic glycogen level on hepatic glucose uptake and disposition
    JASON WINNICK; Fiscal Year: 2009
    ..Elevation of muscle glycogen reduces glucose uptake and glycogen synthesis, however the effect of hepatic glycogen level on hepatic glucose ..
  73. Discovery of potent, and selective allosteric inhibitors of GSK-3b
    JEN PAN; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The serine/threonine kinase glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator for multiple cellular pathways that include insulin signaling and glycogen synthesis, neurotrophic ..