dextran sulfate

Summary

Summary: Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4+ T-lymphocytes. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications.

Top Publications

  1. ncbi Chemically induced mouse models of intestinal inflammation
    Stefan Wirtz
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Mainz, Germany
    Nat Protoc 2:541-6. 2007
  2. pmc Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model
    Malin E V Johansson
    Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 5:e12238. 2010
  3. pmc Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis
    Boryana K Popivanova
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    J Clin Invest 118:560-70. 2008
  4. pmc Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis
    Philip Alex
    Div of Gastroenterology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Inflamm Bowel Dis 15:341-52. 2009
  5. pmc STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    Geethanjali Pickert
    Institute of Molecular Medicine, Johannes Gutenberg University of Mainz, 55131 Mainz, Germany
    J Exp Med 206:1465-72. 2009
  6. ncbi Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function
    E Cario
    Division of Gastroenterology and Hepatology, University Hospital of Essen and Medical School University of Duisburg Essen, Essen, Germany
    Gastroenterology 132:1359-74. 2007
  7. ncbi Iron supplementation increases disease activity and vitamin E ameliorates the effect in rats with dextran sulfate sodium-induced colitis
    Julie Carrier
    Department of Medicine, University of Toronto, Ontario M5G 2C4, Canada
    J Nutr 132:3146-50. 2002
  8. pmc Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis
    Yutao Yan
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    PLoS ONE 4:e6073. 2009
  9. pmc The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
    Md Hasan Zaki
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 32:379-91. 2010
  10. ncbi Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation
    Silvia Melgar
    AstraZeneca R and D Molndal, Dept of Integrative Pharmacology, GI Biology, SE 431 83 Molndal, Sweden
    Am J Physiol Gastrointest Liver Physiol 288:G1328-38. 2005

Detail Information

Publications302 found, 100 shown here

  1. ncbi Chemically induced mouse models of intestinal inflammation
    Stefan Wirtz
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Mainz, Germany
    Nat Protoc 2:541-6. 2007
    ..The procedures for the hapten models of colitis and acute DSS colitis can be accomplished in about 2 weeks but the protocol for chronic DSS colitis takes about 2 months...
  2. pmc Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model
    Malin E V Johansson
    Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 5:e12238. 2010
    ..b>Dextran Sulfate (DSS) in the drinking water is the most widely used animal model for experimental colitis...
  3. pmc Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis
    Boryana K Popivanova
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    J Clin Invest 118:560-70. 2008
    ..we used a mouse model of the disease whereby administration of azoxymethane (AOM) followed by repeated dextran sulfate sodium (DSS) ingestion causes severe colonic inflammation and the subsequent development of multiple tumors...
  4. pmc Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis
    Philip Alex
    Div of Gastroenterology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Inflamm Bowel Dis 15:341-52. 2009
    ....
  5. pmc STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    Geethanjali Pickert
    Institute of Molecular Medicine, Johannes Gutenberg University of Mainz, 55131 Mainz, Germany
    J Exp Med 206:1465-72. 2009
    ..In summary, our data suggest that intestinal epithelial STAT3 activation regulates immune homeostasis in the gut by promoting IL-22-dependent mucosal wound healing...
  6. ncbi Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function
    E Cario
    Division of Gastroenterology and Hepatology, University Hospital of Essen and Medical School University of Duisburg Essen, Essen, Germany
    Gastroenterology 132:1359-74. 2007
    ..The aim of this study was to determine the functional relevance of TLR2 to control tight junction (TJ)-associated intestinal epithelial barrier integrity to balance mucosal homeostasis against inflammatory stress-induced damage...
  7. ncbi Iron supplementation increases disease activity and vitamin E ameliorates the effect in rats with dextran sulfate sodium-induced colitis
    Julie Carrier
    Department of Medicine, University of Toronto, Ontario M5G 2C4, Canada
    J Nutr 132:3146-50. 2002
    ..This study was designed to determine in rats with dextran sulfate sodium (DSS)-induced colitis whether oral iron supplementation increases intestinal inflammation and ..
  8. pmc Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis
    Yutao Yan
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    PLoS ONE 4:e6073. 2009
    ..Murine colitis model induced by Dextran Sulfate Sodium (DSS) is an animal model of IBD that is commonly used to address the pathogenesis of IBD as well as to ..
  9. pmc The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
    Md Hasan Zaki
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 32:379-91. 2010
    ..Thus, the Nlrp3 inflammasome is critically involved in the maintenance of intestinal homeostasis and protection against colitis...
  10. ncbi Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation
    Silvia Melgar
    AstraZeneca R and D Molndal, Dept of Integrative Pharmacology, GI Biology, SE 431 83 Molndal, Sweden
    Am J Physiol Gastrointest Liver Physiol 288:G1328-38. 2005
    Exposure to dextran sulfate sodium (DSS) induces acute colitis, which is normally resolved after DSS removal...
  11. pmc Importance and regulation of the colonic mucus barrier in a mouse model of colitis
    J Petersson
    Department of Medical Cell Biology, Division of Integrative Physiology, Biomedical Center, Uppsala Univ, P O Box 571, SE 751 23 Uppsala, Sweden
    Am J Physiol Gastrointest Liver Physiol 300:G327-33. 2011
    ..Furthermore, the ability of bacteria to regulate the thickness of the colonic mucus was demonstrated...
  12. ncbi Cordyceps militaris extract suppresses dextran sodium sulfate-induced acute colitis in mice and production of inflammatory mediators from macrophages and mast cells
    Eun Su Han
    Department of Bioscience and Biotechnology, Konkuk University, 1 Hwayang dong, Kwangjin gu, Seoul 143 701, Republic of Korea
    J Ethnopharmacol 134:703-10. 2011
    ..Cordyceps militaris is a well-known medicinal mushroom used for treatment of asthma, and other bronchial and lung inflammatory diseases...
  13. ncbi GCMS-based metabolomic study in mice with colitis induced by dextran sulfate sodium
    Yuuki Shiomi
    Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Kobe, Japan
    Inflamm Bowel Dis 17:2261-74. 2011
    ....
  14. pmc Interferon-gamma (IFN-gamma)- and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)-induced colitis in mice
    F Obermeier
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Clin Exp Immunol 116:238-45. 1999
    ..The combination of anti-cytokine treatments had additive effects. TNF and IFN-gamma are involved in perpetuation of chronic DSS-induced colitis, and induction of excessive nitric oxide activity could be their common effector mechanism...
  15. pmc Dextran sodium sulfate (DSS) induces colitis in mice by forming nano-lipocomplexes with medium-chain-length fatty acids in the colon
    Hamed Laroui
    Department of Biology, Center Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, United States of America
    PLoS ONE 7:e32084. 2012
    ..The deleterious effect of DSS is localized principally in the distal colon, therefore it will be important to chemically modify DSS to develop materials beneficial to the colon without affecting colon-targeting specificity...
  16. ncbi An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression
    Clemens Neufert
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    Nat Protoc 2:1998-2004. 2007
    ..Different scoring systems including number of tumors and tumor size identify factors promoting or inhibiting tumor initiation and/or tumor progression, respectively...
  17. pmc Angiogenesis blockade as a new therapeutic approach to experimental colitis
    Silvio Danese
    Division of Gastroenterology, Istituto Clinico Humanitas, Rozzano, Milan 20089, Italy
    Gut 56:855-62. 2007
    ..Neoangiogenesis is a critical component of chronic inflammatory disorders. Inhibition of angiogenesis is an effective treatment in animal models of inflammation, but has not been tested in experimental colitis...
  18. pmc Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine
    Masayuki Fukata
    Inflammatory Bowel Disease Center, Division of Gastroenterology, New York, New York, USA
    Gastroenterology 131:862-77. 2006
    ..We wished to test the hypothesis that cyclooxygenase 2 (Cox-2)-derived prostaglandin E2 (PGE2) is important in TLR4-related mucosal repair...
  19. pmc Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease
    Mayumi Kawada
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, MA 02114, USA
    World J Gastroenterol 13:5581-93. 2007
    ..We also summarize some regulatory and pathogenic factors demonstrated by these models that can, hopefully, be exploited to develop future therapeutic strategies against IBD...
  20. pmc The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
    Kenji Kabashima
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    J Clin Invest 109:883-93. 2002
    ..We conclude that EP4 maintains intestinal homeostasis by keeping mucosal integrity and downregulating immune response...
  21. ncbi Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production
    B Siegmund
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1264-73. 2001
    ..the role of IL-18 in intestinal inflammation, the effect of neutralizing antimurine IL-18 antiserum in dextran sulfate sodium (DSS)-induced colitis in BALB/c and C57BL/6 mice was examined...
  22. ncbi Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease
    Anje A te Velde
    Center of Experimental and Molecular Medicine, AMC, Amsterdam, The Netherlands
    Inflamm Bowel Dis 13:325-30. 2007
    ..Mouse models of inflammatory bowel diseases (IBD) are used to unravel the pathophysiology of IBD and to study new treatment modalities, but their relationship to Crohn's disease (CD) or ulcerative colitis (UC) is speculative...
  23. pmc Protection of the intestinal mucosa by intraepithelial gamma delta T cells
    Yaping Chen
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:14338-43. 2002
    ..These results suggest that gammadelta IEL help preserve the integrity of damaged epithelial surfaces by providing the localized delivery of an epithelial cell growth factor...
  24. ncbi Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice
    Reiko Ito
    Department of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Biochem Biophys Res Commun 377:12-6. 2008
    ..The present results show that IL-17A plays a pivotal role in the pathogenesis of DSS-induced colitis, while MCP-1 and G-CSF may be crucially involved in the IL-17A-induced inflammation...
  25. ncbi Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism
    Philip Smith
    Institute of Molecular Medicine, St James s Hospital, Trinity College Dublin, Dublin 8, Ireland
    J Immunol 178:4557-66. 2007
    ..Therefore, we propose a new mechanism whereby a parasitic worm suppresses DSS-induced colitis via a novel colon-infiltrating macrophage population...
  26. pmc CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
    A Suzuki
    Institute of Life Science, Kurume University, Kurume 839-0861, Japan
    J Exp Med 193:471-81. 2001
    ..most strongly tyrosine phosphorylated in human ulcerative colitis and Crohn's disease patients as well as in dextran sulfate sodium (DSS)-induced colitis in mice...
  27. ncbi Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome
    Christian Bauer
    Medizinische Klinik Innenstadt, University of Munich, Ziemssenstr 1, D 80336 Munich, Germany
    Gut 59:1192-9. 2010
    ..Here, the role of the NLRP3 inflammasome in experimental colitis induced by dextran sodium sulfate (DSS) was examined...
  28. ncbi Interleukin-33 suppresses Notch ligand expression and prevents goblet cell depletion in dextran sulfate sodium-induced colitis
    Hirotsugu Imaeda
    Department of Medicine, Graduate School of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Japan
    Int J Mol Med 28:573-8. 2011
    ..IL-33-induced goblet cell hyperplasia, we investigated how IL-33 modulates the Notch signaling pathway in dextran sulfate sodium (DSS)-induced experimental colitis...
  29. ncbi Increased apoptosis and decreased proliferation of colonic epithelium in dextran sulfate sodium-induced colitis in mice
    Yoshio Araki
    Department of Pathology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Oncol Rep 24:869-74. 2010
    ..In animal models, the oral administration of dextran sulfate sodium (DSS) induces colitis, which exhibits several clinical and histological features similar to UC...
  30. ncbi Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis
    M Mahler
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Am J Physiol 274:G544-51. 1998
    b>Dextran sulfate sodium (DSS)-induced murine colitis represents an experimental model for human inflammatory bowel disease...
  31. ncbi Dysplasia and cancer in the dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: a study of histopathology, B-catenin and p53 expression and the role of inflammation
    H S Cooper
    Department of Pathology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Carcinogenesis 21:757-68. 2000
    ..and p53 along with the histopathology and inflammation scores as they relate to dysplasia and cancer in the dextran sulfate sodium (DSS) colitis model...
  32. ncbi Suppression of experimental colitis by intestinal mononuclear phagocytes
    Joseph E Qualls
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, College of Medicine, Lexington, KY 40536 0084, USA
    J Leukoc Biol 80:802-15. 2006
    ..study was to determine if intestinal mononuclear phagocytes (iMNP) serve a pathological or protective role in dextran sulfate sodium (DSS)-induced colitis in mice...
  33. ncbi Enhanced survival and mucosal repair after dextran sodium sulfate-induced colitis in transgenic mice that overexpress growth hormone
    K L Williams
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
    Gastroenterology 120:925-37. 2001
    ..Transgenic mice overexpressing GH (MT1-bGH-TG) were used to test whether increased plasma GH levels alter inflammation or crypt damage during dextran sodium sulfate (DSS)-induced colitis...
  34. ncbi Characterisation of acute murine dextran sodium sulphate colitis: cytokine profile and dose dependency
    B Egger
    Department of Visceral and Transplantation Surgery, University of Bern, Switzerland
    Digestion 62:240-8. 2000
    ..To clarify this important topic, we performed a dose and concentration dependency study of DSS in Balb/c mice. We also determined Th1 and Th2 cytokine levels to compare the cytokine profile to that from inflammatory bowel disease (IBD)...
  35. pmc In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy
    C Becker
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Gut 54:950-4. 2005
    ..In the past, mice had to be sacrificed in order to analyse colitis activity and tumour development. We have developed a safe method for high resolution endoscopic monitoring of living mice...
  36. ncbi Induction and activation of adaptive immune populations during acute and chronic phases of a murine model of experimental colitis
    Lindsay J Hall
    Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland
    Dig Dis Sci 56:79-89. 2011
    ..Despite its continuing importance as a model system for examining IBD pathogenesis, the mucosal and systemic immune responses have not been comprehensively documented...
  37. ncbi Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease
    Silvia Melgar
    Department of Integrative Pharmacology, AstraZeneca R and D Molndal, Sweden
    Int Immunopharmacol 8:836-44. 2008
    b>Dextran sulfate sodium (DSS)-induced colitis is one of the most frequently used rodent models for inflammatory bowel disease (IBD)...
  38. pmc Dextran sulfate sodium leads to chronic colitis and pathological angiogenesis in Endoglin heterozygous mice
    Mirjana Jerkic
    Molecular Structure and Function Program, Hospital for Sick Children, Toronto, Ontario, Canada
    Inflamm Bowel Dis 16:1859-70. 2010
    ..In this study we investigated its potential role in the regulation of inflammation by testing the response of Endoglin heterozygous (Eng(+/-)) mice to experimental colitis...
  39. ncbi Drug-loaded nanoparticles targeted to the colon with polysaccharide hydrogel reduce colitis in a mouse model
    Hamed Laroui
    Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 138:843-53.e1-2. 2010
    ..We engineered nanoparticles (NPs) to deliver an anti-inflammatory tripeptide Lys-Pro-Val (KPV) to the colon and assessed its therapeutic efficacy in a mouse model of colitis...
  40. ncbi Role of gamma delta T cells in the inflammatory response of experimental colitis mice
    Takahiro Tsuchiya
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    J Immunol 171:5507-13. 2003
    We examined the severity of experimental colitis induced by dextran sulfate sodium (DSS) using immunologically manipulated mice...
  41. pmc Temporal genomewide expression profiling of DSS colitis reveals novel inflammatory and angiogenesis genes similar to ulcerative colitis
    Kai Fang
    Department of Pathology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana 71103, USA
    Physiol Genomics 43:43-56. 2011
    ..This study provides a comprehensive view of DSS colitis changes in colon gene expression and identifies common molecules with clinical specimens that are interesting targets for further investigation...
  42. ncbi The absence of functional PI3Kgamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice
    Willemijn A van Dop
    Center for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands
    Immunol Lett 131:33-9. 2010
    ..These results suggest that PI3Kgamma plays a critical role in lamina propria leukocyte trafficking and that loss of PI3Kgamma-activity ameliorates DSS-induced colitis in mice...
  43. ncbi An orally active matrix metalloproteinase inhibitor, ONO-4817, reduces dextran sulfate sodium-induced colitis in mice
    Y Naito
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, 602 8566, Kyoto, Kawaramachi Hirokoji, Japan
    Inflamm Res 53:462-8. 2004
    ..A dextran sulfate sodium (DSS) colitis model was established to examine the effects of MMP inhibition, by an orally active MMP ..
  44. pmc MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model
    Caitlyn W Barrett
    Department of Medicine Gastroenterology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Cancer Res 71:1302-12. 2011
    ..This represents the first report functionally linking MTGR1 to intestinal tumorigenesis...
  45. ncbi N-acetylcysteine improves redox status, mitochondrial dysfunction, mucin-depleted crypts and epithelial hyperplasia in dextran sulfate sodium-induced oxidative colitis in mice
    Ilhem Amrouche-Mekkioui
    Faculte des Sciences Biologiques, Laboratoire de Biologie Cellulaire et Moleculaire, Université des Sciences et de Technologie Houari Boumédiène, BP 32, El Alia 16111, Bab Ezzouar, Alger, Algerie
    Eur J Pharmacol 691:209-17. 2012
    ..Male NMRI mice were given 5% dextran sulfate sodium (DSS) in drinking water for 5 days followed by 10 days of water, three times...
  46. pmc Tumor necrosis factor-α and Muc2 mucin play major roles in disease onset and progression in dextran sodium sulphate-induced colitis
    Poonam Dharmani
    Department of Microbiology, Immunology and Infectious Diseases, Gastrointestinal Research Group, Health Sciences Centre, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 6:e25058. 2011
    ..We conclude that early onset colitis is dependent on TNF-α that preceded depletion of adherent and goblet cell mucin prior to epithelial cell damage and these biomarkers can be used as therapeutic targets for UC...
  47. pmc Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation
    Nancy Liu
    Department of Orthopaedic Surgery, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
    Endocrinology 149:4799-808. 2008
    ..These data indicate that both local and endocrine synthesis of 1,25(OH)2D3 affect colitis in DSS-treated mice. Lack of Cyp27b1 exacerbates disease in this model, suggesting that similar effects may occur with vitamin D deficiency...
  48. ncbi PACAP provides colonic protection against dextran sodium sulfate induced colitis
    Yasu Taka Azuma
    Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Graduate School of Life and Environmental Science, Osaka Prefecture University, Sakai, Osaka, Japan
    J Cell Physiol 216:111-9. 2008
    ..PACAP-deficient (PACAP-/-) mice and wild-type control mice were challenged by colitis-inducing agent, dextran sulfate sodium (DSS)...
  49. ncbi Aggravation of intestinal inflammation by depletion/deficiency of gammadelta T cells in different types of IBD animal models
    Anja A Kuhl
    Medizinische Klinik I, and Institute of Pathology, Charite, University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin D 12200, Germany
    J Leukoc Biol 81:168-75. 2007
    ..Particularly, during the early phase of intestinal inflammation, gammadelta T cells appear to be important. The mechanism seems to involve the control of IFN-gamma production and epithelial regeneration...
  50. pmc Murine model of dextran sulfate sodium-induced colitis reveals Candida glabrata virulence and contribution of β-mannosyltransferases
    Samir Jawhara
    Universite Lille Nord de France, 59000 Lille, France
    J Biol Chem 287:11313-24. 2012
    ..glabrata, their role in C. glabrata colonization and virulence was investigated in a murine model of dextran sulfate sodium (DSS)-induced colitis. Five clustered genes of C...
  51. pmc ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival
    Yongqin Zhang
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University School of Medicine, Nashville, TN, USA
    Lab Invest 92:437-50. 2012
    ..In this study, mice bearing intestinal epithelial-specific deletion of ErbB2 or ErbB3 were treated with dextran sulfate sodium (DSS)...
  52. pmc L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis
    Lori A Coburn
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 7:e33546. 2012
    ..Using dextran sulfate sodium (DSS) as a murine colonic injury and repair model with similarities to human UC, we assessed the ..
  53. pmc Protective role of 1,25(OH)2 vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice
    Hongwei Zhao
    Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, NO, 215 Heping West Road, 050000, Shijiazhuang, China
    BMC Gastroenterol 12:57. 2012
    ..The purpose of this study is to investigate the possible protective effects of 1,25(OH)2D3 on mucosal injury and epithelial barrier disruption on dextran sulfate sodium (DSS)-induced acute colitis model.
  54. pmc TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation
    Hidetoshi Takedatsu
    Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California, USA
    Gastroenterology 135:552-67. 2008
    ..Expression of TL1A is increased in the mucosa of Crohn's disease patients and murine models of ileitis. The aim of this study was to determine the possible role of TL1A in chronic intestinal inflammation...
  55. pmc High-dose green tea polyphenols induce nephrotoxicity in dextran sulfate sodium-induced colitis mice by down-regulation of antioxidant enzymes and heat-shock protein expressions
    Hirofumi Inoue
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Japan
    Cell Stress Chaperones 16:653-62. 2011
    Previously, we reported that oral feeding of 1% green tea polyphenols (GTPs) aggravated the dextran sulfate sodium (DSS)-induced colitis in mice...
  56. pmc Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide
    C F Krieglstein
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    J Exp Med 194:1207-18. 2001
    ..oxidase, transgenic (Tg) mice that overexpress SOD, and their respective wild-type (WT) littermates were fed dextran sulfate sodium (DSS) in drinking water for 7 days to induce colitis...
  57. pmc Apple polyphenols require T cells to ameliorate dextran sulfate sodium-induced colitis and dampen proinflammatory cytokine expression
    Jerod A Skyberg
    Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, USA
    J Leukoc Biol 90:1043-54. 2011
    ..Collectively, these results show that oral administration of APP protects against experimental colitis and diminishes proinflammatory cytokine expression via T cells...
  58. pmc The noncommensal bacterium Methylococcus capsulatus (Bath) ameliorates dextran sulfate (Sodium Salt)-Induced Ulcerative Colitis by influencing mechanisms essential for maintenance of the colonic barrier function
    Charlotte R Kleiveland
    Department of Chemistry, Biotechnology and Food Science, The Norwegian University of Life Sciences, As, Norway
    Appl Environ Microbiol 79:48-56. 2013
    ..Brevibacillus agri, and Aneurinibacillus sp. At day 8, colitis was induced by 3.5% dextran sulfate sodium (DSS) ad libitum in the drinking water for 6 days...
  59. ncbi Genetic analysis of susceptibility to dextran sulfate sodium-induced colitis in mice
    M Mahler
    The Jackson Laboratory, Bar Harbor, Maine, 04609 1500, USA
    Genomics 55:147-56. 1999
    The genetic basis for differential sensitivity of inbred mice to inflammatory bowel disease induced by dextran sulfate sodium (DSS) is unknown. Susceptible C3H/HeJ were outcrossed to partially resistant C57BL/6J mice...
  60. pmc β-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARγ pathway
    Allisson Freire Bento
    Department of Pharmacology, Biological Sciences Center, Federal University of Santa Catarina Florianópolis, Santa Catarina, Brazil
    Am J Pathol 178:1153-66. 2011
    ..In this study, we examined the anti-inflammatory effect of BCP in dextran sulfate sodium (DSS)-induced colitis and analyzed whether this effect was mediated by CB2 and PPARγ...
  61. ncbi Amelioration of murine dextran sulfate sodium-induced colitis by nuclear factor-kappaB decoy oligonucleotides
    Jun Ying Xiang
    Department of Gastroenterology, West China Hospital, Sichuan University, Sichuan, China
    Am J Surg 197:797-805. 2009
    ..The purpose of the current study was to investigate the effects of NF-kappaB decoy oligonucleotides (ODNs) on an experimental model of UC...
  62. pmc Role of leptin receptor-induced STAT3 signaling in modulation of intestinal and hepatic inflammation in mice
    Melissa E Gove
    Kinesiology and Nutrition Department, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Leukoc Biol 85:491-6. 2009
    Leptin-deficient ob/ob mice are resistant to dextran sulfate sodium (DSS)-induced colitis and Concanavalin A (Con A)-induced hepatitis. However, the signal transduction pathways involved have not been identified...
  63. ncbi Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice
    J H Cox
    Department of Molecular Biology, Genentech, South San Francisco, California, USA
    Mucosal Immunol 5:99-109. 2012
    ..Here we investigate the consequence of IL-23R deletion in dextran sulfate sodium (DSS)-induced colitis...
  64. ncbi Protective effect of lactulose on dextran sulfate sodium-induced colonic inflammation in rats
    György Rumi
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmacological University, Yamashina, Kyoto, Japan
    Dig Dis Sci 49:1466-72. 2004
    ..The purpose of the study was to examine the effect of lactulose on an UC model induced by 3% dextran sulfate sodium (DSS) solution added to drinking water for 7 days in male Wistar rats...
  65. ncbi Therapeutic implications of the specific inhibition of causative matrix metalloproteinases in experimental colitis induced by dextran sulphate sodium
    K Kobayashi
    First Department of Internal Medicine, Sapporo Medical University, Sapporo 060 8543, Japan
    J Pathol 209:376-83. 2006
    ..We conclude that MMP-3 and MMP-10 play a causal role in excess tissue destruction in colitis. Specific inhibition of these MMPs should provide novel therapeutics against IBD...
  66. ncbi Therapeutic effect of blocking CXCR2 on neutrophil recruitment and dextran sodium sulfate-induced colitis
    Shukkur Muhammed Farooq
    Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
    J Pharmacol Exp Ther 329:123-9. 2009
    ..Antagonizing CXCR2 may form the basis for therapeutic drugs directed at controlling colitis...
  67. ncbi Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice
    Takahiro Ishikura
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Gastroenterol Hepatol 18:960-9. 2003
    ..However, the initial role of IL-18 during intestinal inflammation was unclear; therefore the susceptibility of IL-18 transgenic (Tg) mice to acute dextran sulfate sodium (DSS)-induced colitis was examined.
  68. ncbi Analysis of intestinal fibrosis in chronic colitis in mice induced by dextran sulfate sodium
    Kenji Suzuki
    Department of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata City, Niigata, Japan
    Pathol Int 61:228-38. 2011
    ..their role in intestinal fibrosis, we analyzed the lesions of chronic colitis in C57BL/6 (B6) mice induced by dextran sulfate sodium (DSS)...
  69. pmc Cathelicidin signaling via the Toll-like receptor protects against colitis in mice
    Hon Wai Koon
    Inflammatory Bowel Disease Center, Division of Digestive Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA
    Gastroenterology 141:1852-63.e1-3. 2011
    ..We examined whether macrophages express cathelicidin in colons of mice with experimental colitis and patients with inflammatory bowel disease, and we investigated its signaling mechanisms...
  70. ncbi Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice
    L J Saubermann
    Division of Gastroenterology and the Harvard Digestive Diseases Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Gastroenterology 119:119-28. 2000
    ..1(+) T cells. These NK T cells exhibit important immunoregulatory functions in several autoimmune disease models...
  71. ncbi Carbon monoxide liberated from carbon monoxide-releasing molecule exerts an anti-inflammatory effect on dextran sulfate sodium-induced colitis in mice
    Tomohisa Takagi
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Dig Dis Sci 56:1663-71. 2011
    ..The purpose of this investigation was to determine whether exogenous CO could modulate intestinal inflammation...
  72. ncbi Enhanced intestinal inflammation induced by dextran sulfate sodium in tumor necrosis factor-alpha deficient mice
    Yuji Naito
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    J Gastroenterol Hepatol 18:560-9. 2003
    ..To further define the role of TNF-alpha in intestinal inflammation, we studied the effects of dextran sulfate sodium (DSS) administration in mice with targeted deletions of TNF-alpha gene.
  73. ncbi Marginal zinc deficiency exacerbates experimental colitis induced by dextran sulfate sodium in rats
    Hitoshi Iwaya
    Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589 Japan
    J Nutr 141:1077-82. 2011
    ..We then evaluated whether MZD modulated dextran sulfate sodium (DSS)-induced colonic inflammation by administering 2% DSS to the MZD and ZA groups for 7 d...
  74. ncbi Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats
    Fumio Tanaka
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Life Sci 83:771-9. 2008
    ..We examined the therapeutic effects of exogenously administered MSCs in dextran sulfate sodium (DSS)-induced colitis in rats.
  75. pmc Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitis
    Udai P Singh
    Department of Pathology, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    J Pharmacol Exp Ther 332:829-39. 2010
    ..Furthermore, our results indicate that resveratrol may protect against colitis through up-regulation of SIRT1 in immune cells in the colon...
  76. ncbi In vitro effects of dextran sulfate sodium on a Caco-2 cell line and plausible mechanisms for dextran sulfate sodium-induced colitis
    Yoshio Araki
    First Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Shiga, Japan
    Oncol Rep 16:1357-62. 2006
    ..In an IBD animal model, the oral administration of polysaccharides such as dextran sulfate sodium (DSS) induces colitis, which exhibit several clinical and histological features for IBD...
  77. ncbi Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis
    Nicole Schmidt
    Max Planck Institute for Infection Biology, Chariteplatz 1, Berlin, Germany
    Gut 59:896-906. 2010
    ..The aim of this study was to explore whether modulation of the proteasomal activity is a suitable therapeutic approach to limit inflammation in colitis...
  78. ncbi Dextran sodium sulfate-induced colitis in germ-free IQI/Jic mice
    S Kitajima
    Center for Laboratory Animals, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan
    Exp Anim 50:387-95. 2001
    ..Furthermore, DSS may be highly toxic to GF mice, and when given at a concentration of 5% it causes massive bleeding into the intestinal lumen resulting in death prior to development of colitis...
  79. ncbi Serotonin has a key role in pathogenesis of experimental colitis
    Jean Eric Ghia
    Farncombe Family Digestive Health Research Institute, Department of Pathology and Molecular Medicine, McMaster University, Ontario, Canada
    Gastroenterology 137:1649-60. 2009
    ..We investigated the role of 5-HT in colonic inflammation in mice...
  80. ncbi The role of dendritic cells in the development of acute dextran sulfate sodium colitis
    Bradford E Berndt
    Gastroenterology Division, Department of Internal Medicine
    J Immunol 179:6255-62. 2007
    ..In this study, we investigate the role of DCs in the pathogenesis of a widely used colitis model, dextran sulfate sodium-induced colitis...
  81. ncbi Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model
    Satoshi Matsumoto
    Yakult Central Institute for Microbiological Research, Tokyo, Japan
    J Immunol 184:1543-51. 2010
    ..Treatment with soluble gp130Fc significantly reduced the CApC. IL-6 trans-signaling in epithelial cells induced by macrophage-derived IL-6/sIL-6R alpha plays a crucial role in the development of CAC...
  82. ncbi Loss of the tight junction protein ZO-1 in dextran sulfate sodium induced colitis
    Lisa S Poritz
    Department of Surgery and Department of Pathology, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Surg Res 140:12-9. 2007
    ..This study looked at the expression of the TJ protein ZO-1 and the corresponding permeability changes in dextran sulfate sodium (DSS) induced colitis in a mouse model.
  83. pmc Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency
    Daniel K Podolsky
    Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
    Gastroenterology 137:209-20. 2009
    ..The aim of this study was to determine whether Toll-like receptor (TLR) 2 and modulation of GC-derived trefoil factor (TFF) 3 are functionally linked in the intestine...
  84. ncbi Adenosine kinase inhibitor GP515 improves experimental colitis in mice
    B Siegmund
    Division of Clinical Pharmacology, Medizinische Klinik Innenstadt of the Ludwig Maximilians University, Munich, Germany
    J Pharmacol Exp Ther 296:99-105. 2001
    ..In the present study we investigated the effect of systemic GP515 in the nonacute model of dextran sulfate sodium (DSS)-induced colitis...
  85. ncbi The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model
    Jean Eric Ghia
    Intestinal Diseases Research Programme, Health Science Center, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Gastroenterology 131:1122-30. 2006
    ..The purpose of this study was to determine whether a similar vagus/macrophage axis modulates the inflammatory responses in the colon in mice...
  86. ncbi Treatment of murine colitis by Lactococcus lactis secreting interleukin-10
    L Steidler
    Department of Molecular Biology, Ghent University and Flanders Interuniversity Institute for Biotechnology, K L Ledeganckstraat 35, 9000 Gent, Belgium
    Science 289:1352-5. 2000
    ..administration of IL-10-secreting Lactococcus lactis caused a 50% reduction in colitis in mice treated with dextran sulfate sodium and prevented the onset of colitis in IL-10(-/-) mice...
  87. pmc Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury
    Monica Froicu
    Department of Veterinary and Biomedical Sciences, Pathobiology Graduate Program, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Immunol 8:5. 2007
    ..The active form of vitamin D (1,25(OH)2D3) has been shown to inhibit development of inflammatory bowel disease (IBD) in IL-10 KO mice. Here, the role of the vitamin D receptor (VDR) and 1,25(OH)2D3 in acute experimental IBD was probed...
  88. ncbi Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice
    Jiro Horino
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int Immunol 20:753-62. 2008
    ..In this study, we investigated the role of SOCS-1 in the development of murine dextran sulfate sodium (DSS)-induced colitis, a model of colitis resembling human IBD...
  89. ncbi Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
    Shin Maeda
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Science 307:734-8. 2005
    ..These effects are linked to increased susceptibility to bacterial-induced intestinal inflammation and identify NOD2 as a positive regulator of NF-kappaB activation and IL-1beta secretion...
  90. ncbi Dysplasia and carcinoma development in a repeated dextran sulfate sodium-induced colitis model
    Isao Okayasu
    Department of Pathology, School of Medicine, Kitasato University, Sagamihara Kanagawa, Japan
    J Gastroenterol Hepatol 17:1078-83. 2002
    ..In the present study, a dysplasia-carcinoma sequence in a novel repeated colitis model in mice is documented...
  91. ncbi A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate
    Takuji Tanaka
    The First Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293
    Cancer Sci 94:965-73. 2003
    ....
  92. ncbi Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection
    Maria Van Der Sluis
    Division of Neonatology, Department of Pediatrics, Erasmus MC and Sophia Children s Hospital, Rotterdam, The Netherlands
    Gastroenterology 131:117-29. 2006
    ..Expression of mucin MUC2, the structural component of the colonic mucus layer, is lowered in inflammatory bowel disease. Our aim was to obtain insight in the role of Muc2 in epithelial protection...
  93. pmc Activation of aryl hydrocarbon receptor (AhR) leads to reciprocal epigenetic regulation of FoxP3 and IL-17 expression and amelioration of experimental colitis
    Narendra P Singh
    Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States of America
    PLoS ONE 6:e23522. 2011
    ..In the current study, we investigated the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a potent AhR ligand, on epigenetic regulation leading to altered Treg/Th17 differentiation, and consequent suppression of colitis...
  94. ncbi Antisense oligonucleotide blockade of tumor necrosis factor-alpha in two murine models of colitis
    Kathleen J Myers
    Isis Pharmaceuticals, Carlsbad, California 92008, USA
    J Pharmacol Exp Ther 304:411-24. 2003
    ..In both the DSS and IL-10 -/- models, scrambled and mismatch control oligonucleotides were largely without effect, suggesting that ISIS 25302 was exerting its effects through a sequence-dependent antisense mechanism...
  95. pmc Comparative efficacies of 2 cysteine prodrugs and a glutathione delivery agent in a colitis model
    Helieh S Oz
    Center for the Oral Health Research and Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Transl Res 150:122-9. 2007
    ..These abnormalities were attenuated in prodrug-treated mice. In conclusion, these data strongly support the novel action of the PTCA against colitis, which further supports a possible therapeutic application for IBD patients...
  96. ncbi ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
    Tatsuo Hashimoto
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
    Nature 487:477-81. 2012
    ..These results provide a molecular explanation for how amino acid malnutrition can cause intestinal inflammation and diarrhoea...
  97. ncbi Role of TNF receptors, TNFR1 and TNFR2, in dextran sodium sulfate-induced colitis
    RoseMarie Stillie
    Department of Microbiology and Immunology, Dalhousie University, IWK Health Centre, Halifax, Nova Scotia, Canada
    Inflamm Bowel Dis 15:1515-25. 2009
    In this study we determined the consequence of the absence of each TNF receptor, TNFR1 or TNFR2, in the dextran sulfate sodium (DSS) model of colitis.
  98. pmc Functionally enhanced siRNA targeting TNFα attenuates DSS-induced colitis and TLR-mediated immunostimulation in mice
    Sandra M Ocampo
    Institute for Advanced Chemistry of Catalonia IQAC, Spanish Research Council CSIC, Barcelona, Spain
    Mol Ther 20:382-90. 2012
    ..Consequently, this strategy has potential implications for therapeutic intervention in IBD and other diseases...
  99. ncbi The interleukin-1 beta-converting enzyme inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and T helper 1 T-cell activation
    Florian Loher
    Division of Clinical Pharmacology, Medizinische Klinik Innenstadt of the University of Munich, Germany
    J Pharmacol Exp Ther 308:583-90. 2004
    ..In the present study, we investigated the effect of the specific ICE inhibitor pralnacasan in dextran sulfate sodium-induced murine colitis. Colitis was induced in BALB/c mice by 3...
  100. pmc The Wnt antagonist Dkk1 regulates intestinal epithelial homeostasis and wound repair
    Stefan Koch
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 141:259-68, 268.e1-8. 2011
    ..We investigated whether inhibition of Dkk1 affects the morphology and function of the adult intestine...
  101. ncbi Dextran sulfate sodium-induced colitis generates a transient thymic involution--impact on thymocyte subsets
    M Fritsch Fredin
    Department of Integrative Pharmacology, AstraZeneca R and D Molndal, Molndal, Sweden
    Scand J Immunol 65:421-9. 2007
    One of the most widely used animal models for inflammatory bowel disease (IBD) is the dextran sulfate sodium (DSS)-induced colitis...

Research Grants63

  1. Treatment of Inflammatory Bowel Disease with Ceramidase Inhibitors
    Lynn W Maines; Fiscal Year: 2012
    ..Each of the novel ceramidase inhibitors will be tested for efficacy in the dextran sulfate sodium (DSS) model of ulcerative colitis in mice, using a combination of clinical, morphological and ..
  2. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
    ..Specific Aims: Establish the pharmacodynamic profile of mR-421 in mice utilizing 1) a dextran sulfate sodium (DSS) model and 2) a dintrobenzenesulfonic (DNBS) model of intestinal inflammation Treatment with mR-..
  3. Eotaxin in Colitis and Colitis-Associated Carcinogenesis
    Lori A Coburn; Fiscal Year: 2013
    ..Eotaxin-1 has been shown to be increased in dextran sulfate sodium (DSS) induced colitis by my collaborator, and we now show for the first time that eotaxin-1 is ..
  4. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith T Wilson; Fiscal Year: 2013
    ..and oral L-Arg supplementation is effective as a treatment for epithelial injury and inflammation induced by dextran sulfate sodium (DSS), a model that mimics UC...
  5. Regulation of colitis by orphan nuclear receptor Nur77
    Dezheng Zhao; Fiscal Year: 2013
    ..To this end, we have shown that Nur77 is highly induced in acute trisnitrobenzene sulfonic acid (TNBS) and dextran sulfate sodium (DSS) experimental colitis...
  6. The Role of a Novel Vitamin E Metabolite in Colon Cancer Prevention and Therapy
    Qing Jiang; Fiscal Year: 2012
    ..in a mouse model, in which colon carcinogenesis is induced by azoxymethane (AOM) and is accelerated by dextran sulfate sodium (DSS)-caused colon inflammation...
  7. Molecular Mechanisms Regulating Intestinal Homeostasis
    Vincent W Yang; Fiscal Year: 2013
    ..In addition, it was shown recenty that KLF5 is necessary for mucosal healing in the dextran sulfate sodium (DSS) mouse model of colitis...
  8. Eosinophil Peroxidase in Allergic Inflammation
    Arne Slungaard; Fiscal Year: 2012
    ..precursors, cyanide-like compounds, ameliorates the severity of inflammatory bowel disease in a murine dextran sulfate model...
  9. Contribution of occludin to intestinal homeostasis and disease
    Le Shen; Fiscal Year: 2013
    ..epithelial cells or by gene knockout in mice, decreases TNF-induced epithelial apoptosis as well as dextran sulfate sodium-induced cell loss and, in vivo, intestinal inflammation...
  10. Mechanism of H. pylori-induced risk reduction for inflammatory bowel disease
    Jay Luther; Fiscal Year: 2009
    ..pylori DNA on mouse susceptibility to chronic dextran sulfate sodium-colitis. Briefly, by using H...
  11. The role of HIF2alpha in colon carcinogenesis
    Yatrik M Shah; Fiscal Year: 2013
    ..This will be examined in a well-characterized CAC model using azoxymethane (AOM) and dextran sulfate sodium (DSS) in mice that are disrupted for HIF2a or mice that overexpress HIF2a specifically in the colon...
  12. Inducible colon-specific transgenic mouse for cancer research
    James C Fleet; Fiscal Year: 2013
    ..Additional studies will be done in the presence of colonic inflammation induced by dextran sulfate sodium (DSS)...
  13. Progranulin Intervention in Inflammatory Bowel Diseases
    Chuanju Liu; Fiscal Year: 2013
    ..in our preliminary studies that the deletion of the PGRN gene renders B6 mice more susceptible to Dextran Sulfate Sodium (DSS) induction and to developing more severe colitis...
  14. Colorectal cancer chemoprevention with phytochemical combinations
    Swati Nagar; Fiscal Year: 2013
    ..Combinations with the highest predicted efficacy from Aim 1 will be tested in a dextran sulfate sodium + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (DSS/PhIP) colon adenocarcinoma mouse model, and ..
  15. A novel agent suppresses colitis and colon cancer
    Nengtai Ouyang; Fiscal Year: 2013
    ..In this proposal, we will further confirm and refine the inhibitory effect of the peptide in dextran sulfate sodium (DSS)-induced acute colitis mouse model...
  16. P53 inactivation on MDSC development and tumor progression
    Yan Cui; Fiscal Year: 2013
    ..in fibroblasts and myeloid precursors synergistically enhances chronic inflammation and tumorigenesis in the dextran sulfate sodium (DSS)-induced colon cancer, whereas targeted restoration of p53 in fibroblast or MDSC delays colon ..
  17. The impact of Helicobacter pylori infection on inflammatory bowel disease suscept
    John Kao; Fiscal Year: 2009
    ..2. To study the impact of H. pylori-induced Tregs on mouse susceptibility to chronic dextran sulfate sodium (DSS)-colitis. 2.1. To demonstrate the presence of extragastric H...
  18. PERIODONTAL DISEASES: B CELLS ACTIVATED BY MITOGENS
    JAMES CLAGETT; Fiscal Year: 1980
    ..Thus, selected PBAs such as dextran sulfate (DS), lipopolysaccharide (LPS) from gram-negative bacteria and AVIS can serve as useful functional markers...
  19. Novel Intervention for Colitis
    MICHAEL VITEK; Fiscal Year: 2007
    ..Specifically, we will employ the acute Citrobacter rodentium (C. rodentium) model, an acute Dextran Sulfate Sodium (DSS) model and a chronic DSS model of colitis...
  20. Metabolism and Carcinogenicity of Heterocyclic Amines
    TERRY ZENSER; Fiscal Year: 2007
    ..b>Dextran sulfate sodium (DSS)-induced colitis is an animal model for studying both inflammation and colitis-associated ..
  21. PATHOPHYSIOLOGY OF AIDS GLOMERULOPATHY
    Bryan Myers; Fiscal Year: 1992
    ..Fractional clearances of uncharged dextrans of graded size and of anionic dextran sulfate will be used to define the magnitude of injury to the size- and charge-selective barriers in the glomerular ..
  22. Early Events in Colitis-Associated Colorectal Cancer
    Wen Chi Chang; Fiscal Year: 2003
    ..The dextran sulfate sodium (DSS) model of induced colitis provides a unique opportunity to evaluate the spectrum of histological ..
  23. Importance of CD5 for the function of regulatory T cells
    Subbarao Bondada; Fiscal Year: 2009
    ..Moreover, our preliminary studies showed that in the dextran sulfate (DSS) induced model of colitis, CD5 knockout mice have a milder form of the disease which we hypothesize is ..
  24. A Novel Cytoprotective Peptide for GI Epithelial Cell
    FREDERICK TOBACK; Fiscal Year: 2005
    ..in human colonic epithelial cell (Caco-2/bbe) cultures subjected to injury by an oxidant, indomethacin, or dextran sulfate sodium (DSS) used to induce colitis in mice, Studies in cell culture indicate that this AMP peptide activates ..
  25. The role of glutathione peroxidase in the pathogenesis of intestinal cancer
    Fong Fong Chu; Fiscal Year: 2010
    ..3) To determine whether pro-oxidant bacteria, Enterococcus faecalis and pro-inflammatory dextran sulfate sodium can increase oxidative stress, gene mutations, and cancer in germ free and conventionally housed Gpx1/..
  26. The role of glutathione peroxidase in the chemopreventi*
    Fong Fong Chu; Fiscal Year: 2006
    ..We will determine the effect of Se-supplementation on chemical-, dextran sulfate sodium, induced colitis in mice expressing wildtype Gpx1 and Gpx2 alleles...
  27. Green Tea Polyphenols: A Novel Approach to IBD
    HELIEH OZ; Fiscal Year: 2005
    ..functional foods to pharmacological) and/or EGCG modulate intestinal injury and immune cell responses in the Dextran Sulfate Sodium (DSS) model of Ulcerative Colitis...
  28. ARTERIAL WALL PROTEOGLYCANS AND FOAM CELL FORMATION
    Parakat Vijayagopal; Fiscal Year: 1993
    ..by taking up several chemically and biologically modified forms of low density lipoprotein (LDL) and LDL-dextran sulfate complex by receptor-mediated processes...
  29. GLOMERULAR HYPERTENSION AND SIEVING OF MACROMOLECULES
    William Deen; Fiscal Year: 1993
    ..Fractional clearances of dextran, ficoll, and dextran sulfate will be measured in normal rats and in rats with various forms of glomerular injury, following chronic or ..
  30. Cytokines and Complement in Nephritis and Colitis
    Feng Lin; Fiscal Year: 2005
    ..that in the absence of DAF, tissue injury is greatly enhanced in nephrotoxic serum-induced nephritis and dextran sulfate sodium-induced colitis and in delayed, possibly NK cell-mediated allograft rejection...
  31. GLUTAMATE (AMPA) RECPTORS
    Vishnu Suppiramaniam; Fiscal Year: 2001
    ..During reconstitution experiments heparin and dextran sulfate induced AMPA channels of very high conductivity...
  32. SUPPRESSING HIV INFECTION BY SUBSTITUTED MONOSACCHARIDES
    Paul Gordon; Fiscal Year: 1990
    ..currently being developed by Kenwood Laboratories exhibit an anti-HIV action analogous to that of emergent dextran sulfate, one of the most potent of the above, without exhibiting the emergent dextran sulfate toxicity and with ..
  33. Peroxynitrite decomposition catalyst for bowel disease
    Andrew Salzman; Fiscal Year: 2003
    ..Using a murine dextran sulfate model of enterocolitis, we have determined that our lead peroxynitrite decomposition catalyst, FP15, ..
  34. PROTEASE INHIBITORS AND INFLAMMATION
    Jeffrey Ware; Fiscal Year: 1999
    ..agent in an in vivo model of inflammation in which ulcerative colitis (UC) was induced in mice by adding dextran sulfate sodium to the drinking water...
  35. EFFECT OF CELLULAR AGING ON ENZYME REGULATION
    Henry Paulus; Fiscal Year: 1980
    ..which involves studying the enzymes in intact cells made permeable to small molecules by the treatment with dextran sulfate. This permeable cell system will permit the study of enzymes at physiological concentrations in their natural ..
  36. SOCS2 and intestinal fibrosis
    Shira Fruchtman; Fiscal Year: 2003
    ..ablation of SOCS2 show more severe fibrosis than WT littermates after acute mucosal injury induced by sodium dextran sulfate (DSS) or colitis induced by trinitrobenzene sulfonic acid (TNBS)...
  37. Probiotics regulate intestinal epithelial cell homeostasis
    Fang Yan; Fiscal Year: 2008
    ..Genes regulated by LGG in colon cells will be identified using DNA microarray. These findings will have significant relevance to further understanding the probiotic regulation of intestinal health. ..
  38. Analysis of the Chemopreventive Activity of FGN 1
    MARGIE CLAPPER; Fiscal Year: 2004
    ....
  39. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  40. Chemoprevention of Colonic NOC Formation and Action
    SIDNEY MIRVISH; Fiscal Year: 2006
    ..Overall results will indicate how fecal NOC levels are controlled and can be reduced, and whether fecal NOC can induce colon cancer. [unreadable] [unreadable] [unreadable]..
  41. Tolerance induction in EAE by epicutaneous immunization
    MARGARET BYNOE; Fiscal Year: 2006
    ..Finally, we will carry out experiments to test whether epicutaneous immunization with autoantigenic peptides is capable of ameliorating EAE. ..
  42. CANDIDATE GENE FOR DIABETIC NEPHROPATHY--MEPRIN BETA
    JUDITH BOND; Fiscal Year: 2002
    ..These studies will establish whether the meprin-b gene is associated with susceptibility to DN in humans, and provide animal models to determine the role of this proteinase in normal kidney and in susceptibility to renal disease. ..
  43. SYNTHETIC GENE CARRIERS TO TREAT CYSTIC FIBROSIS
    FRANCIS SZOKA; Fiscal Year: 2001
    ..abstract_text> ..
  44. Regulatory Role of TNFR1 in Inflammatory Bowel Disease
    Emiko Mizoguchi; Fiscal Year: 2007
    ..We believe the data obtained from this study would provide an important rationale to develop new TNF related therapeutic approaches for human IBD. [unreadable] [unreadable] [unreadable]..
  45. Trichomonas Lipophosphoglycan in Regulation Immune Responses
    Raina Fichorova; Fiscal Year: 2008
    ..vaginalis infections and complications. [unreadable] [unreadable] [unreadable]..
  46. GLOBIN SWITCHING AND ERYTHROID DIFFERENTIATION
    Thalia Papayannopoulou; Fiscal Year: 2002
    ....
  47. REGULATION OF INTESTINAL EPITHELIAL CHEMOKINE SECRETION
    Andrew Gewirtz; Fiscal Year: 2002
    ..In addition to containing an extensive array of basic research equipment, this lab space contains a new thermostatted spectrofluorimeter to be used primarily by Dr. Gewirtz. ..
  48. Improved Secretin Analogs for the Treatment of Autism
    Richard Boismenu; Fiscal Year: 2002
    ..In principle, the technologies developed to generate a more stable and active secretin could be applied to other therapeutic peptides...
  49. Biocompatible Dendritic Polymers : In Vivo Applications
    FRANCIS SZOKA; Fiscal Year: 2002
    ..abstract_text> ..
  50. TNF Receptors of Colonic Epithelial Cells in IBD
    Emiko Mizoguchi; Fiscal Year: 2007
    ..Daniel K. Podolsky from the Division of Gastroenterology and by Dr. Atul K. Bhan from the Immunopathology Unit, both at Massachusetts General Hospital and Harvard Medical School. ..
  51. Role of ghrelin in intestinal inflammation
    Dezheng Zhao; Fiscal Year: 2008
    ....
  52. SUPPRESSION OF T CELL ACTIVATION BY DIETARY FATTY ACIDS
    ROBERT CHAPKIN; Fiscal Year: 2003
    ..g., rheumatoid arthritis), without compromising host defenses. ..
  53. Restoration of beta-catenin signaling by perillyl alcoh*
    Wen Chi Chang; Fiscal Year: 2005
    ..Results from the proposed research will determine the feasibility of developing POH as a chemopreventive agent for patients with colorectal cancer and provide the basis for future R01 funding. ..
  54. SPLICE VARIANTS OF THE HA RECEPTOR FOR ENDOCYTOSIS
    Edward Harris; Fiscal Year: 2005
    ..The significance of HARE isoforms is the potential to create a family of receptors that bind/internalize a host of different GAGs. ..
  55. MEPRINS-METALLOPROTEINASES OF THE KIDNEY AND INTESTINE
    Judith S Bond; Fiscal Year: 2010
    ....
  56. Stem Cells and Gastric Cancer
    TIMOTHY CRAGIN WANG; Fiscal Year: 2010
    ....
  57. MUTANT NOD2 IN INTESTINAL INFLAMMATION AND HOST DISEASE
    Lars Eckmann; Fiscal Year: 2010
    ..Together, the proposed studies are expected to yield important new insights into the physiological functions of mutant NOD2 as a mechanistic basis for designing new strategies in the treatment and prevention of CD. ..
  58. Biocompatible Dendritic Polymers for in vivo Applications
    FRANCIS SZOKA; Fiscal Year: 2009
    ..Completion of this research will enable a variety of substantially improved targeted therapies and diagnostic imaging applications that can be successfully applied to treat humans with cancer. ..
  59. Sphingosine Kinase Inhibitors as Anti-IBD Agents
    LYNN MAINES; Fiscal Year: 2007
    ..Upon the completion of these experiments, we will be ready to begin clinical testing of the single best drug candidate. [unreadable] [unreadable] [unreadable]..
  60. APC PATHWAY--A TARGET FOR CHEMOPREVENTIVE INTERVENTION
    Wen Chi Chang; Fiscal Year: 2005
    ..in nutritional biochemistry when combined with the proposed training in cancer prevention and molecular genetics will provide her with the unique ability to develop both natural and synthetic compounds as clinical chemopreventive agents ..
  61. HMG-CoA reductase inhibitor, tea polyphenols and pancreatic cancer prevention
    Guang Yu Yang; Fiscal Year: 2008
    ....
  62. MECHANISTIC STUDIES ON TEA AND CARCINOGENESIS
    Chung Yang; Fiscal Year: 2005
    ..The applicant and colleagues will address key issues concerning the bioavailability and bioactivities of O-methyl, glucuronide, and sulfate derivatives and two ring-fission metabolites of tea catechins. ..