dextrans

Summary

Summary: A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.

Top Publications

  1. ncbi Recent advances in iron oxide nanocrystal technology for medical imaging
    Claire Corot
    Guerbet Research, BP 57400, 95943 Roissy CDG, France
    Adv Drug Deliv Rev 58:1471-504. 2006
  2. ncbi Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers
    Matthew R Dreher
    Department of Biomedical Engineering, Duke University, Durham, NC, USA
    J Natl Cancer Inst 98:335-44. 2006
  3. ncbi Superparamagnetic iron oxide nanoparticle probes for molecular imaging
    Daniel L J Thorek
    Cellular and Molecular Imaging Group, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Ann Biomed Eng 34:23-38. 2006
  4. pmc Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy
    Carlos Tassa
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Acc Chem Res 44:842-52. 2011
  5. ncbi Characterization of biophysical and metabolic properties of cells labeled with superparamagnetic iron oxide nanoparticles and transfection agent for cellular MR imaging
    Ali S Arbab
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, National Institutes of Health, 10 Center Dr, Rm B1N256, Bethesda, MD 20892, USA
    Radiology 229:838-46. 2003
  6. ncbi Cell tagging with clinically approved iron oxides: feasibility and effect of lipofection, particle size, and surface coating on labeling efficiency
    Lars Matuszewski
    Department of Clinical Radiology, University Hospital Muenster, Albert Schweitzer Strasse 33, D 48129 Muenster, Germany
    Radiology 235:155-61. 2005
  7. ncbi Ferucarbotran (Resovist): a new clinically approved RES-specific contrast agent for contrast-enhanced MRI of the liver: properties, clinical development, and applications
    Peter Reimer
    Department of Radiology, Stadtisches Klinikum Karlsruhe, Moltkestrasse 90, 76133 Karlsruhe, Germany
    Eur Radiol 13:1266-76. 2003
  8. doi A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxide nanoparticles
    Morteza Mahmoudi
    Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Tehran, Iran
    Colloids Surf B Biointerfaces 75:300-9. 2010
  9. doi Effect of crowding by dextrans on the hydrolysis of N-Succinyl-L-phenyl-Ala-p-nitroanilide catalyzed by α-chymotrypsin
    Isabel Pastor
    Department of Physical Chemistry, University of Barcelona UB, Barcelona, Spain
    J Phys Chem B 115:1115-21. 2011
  10. pmc Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis
    Dimitrios Karussis
    Department of Neurology, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem IL 91120, Israel
    Arch Neurol 67:1187-94. 2010

Detail Information

Publications417 found, 100 shown here

  1. ncbi Recent advances in iron oxide nanocrystal technology for medical imaging
    Claire Corot
    Guerbet Research, BP 57400, 95943 Roissy CDG, France
    Adv Drug Deliv Rev 58:1471-504. 2006
    ..Stem cell migration and immune cell trafficking, as well as targeted iron oxide nanoparticles for molecular imaging studies, are at the stage of proof of concept, mainly in animal models...
  2. ncbi Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers
    Matthew R Dreher
    Department of Biomedical Engineering, Duke University, Durham, NC, USA
    J Natl Cancer Inst 98:335-44. 2006
    ..We investigated how molecular weight influences the accumulation of a model macromolecular drug carrier, dextran covalently linked to a fluorophore, in tumors...
  3. ncbi Superparamagnetic iron oxide nanoparticle probes for molecular imaging
    Daniel L J Thorek
    Cellular and Molecular Imaging Group, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Ann Biomed Eng 34:23-38. 2006
    ..In this article, we attempt to illustrate the broad utility of SPIO in molecular imaging, including some of the recent developments, such as the transformation of SPIO into an activatable probe termed the magnetic relaxation switch...
  4. pmc Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy
    Carlos Tassa
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Acc Chem Res 44:842-52. 2011
    ..Finally, the targeted delivery of a photodynamic therapy agent as part of a theranostic nanoparticle successfully increased local cell toxicity and minimized systemic side effects...
  5. ncbi Characterization of biophysical and metabolic properties of cells labeled with superparamagnetic iron oxide nanoparticles and transfection agent for cellular MR imaging
    Ali S Arbab
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, National Institutes of Health, 10 Center Dr, Rm B1N256, Bethesda, MD 20892, USA
    Radiology 229:838-46. 2003
    ..To evaluate the effect of using the ferumoxides-poly-l-lysine (PLL) complex for magnetic cell labeling on the long-term viability, function, metabolism, and iron utilization of mammalian cells...
  6. ncbi Cell tagging with clinically approved iron oxides: feasibility and effect of lipofection, particle size, and surface coating on labeling efficiency
    Lars Matuszewski
    Department of Clinical Radiology, University Hospital Muenster, Albert Schweitzer Strasse 33, D 48129 Muenster, Germany
    Radiology 235:155-61. 2005
    ..To evaluate the effect of lipofection, particle size, and surface coating on labeling efficiency of mammalian cells with superparamagnetic iron oxides (SPIOs)...
  7. ncbi Ferucarbotran (Resovist): a new clinically approved RES-specific contrast agent for contrast-enhanced MRI of the liver: properties, clinical development, and applications
    Peter Reimer
    Department of Radiology, Stadtisches Klinikum Karlsruhe, Moltkestrasse 90, 76133 Karlsruhe, Germany
    Eur Radiol 13:1266-76. 2003
    ....
  8. doi A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxide nanoparticles
    Morteza Mahmoudi
    Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Tehran, Iran
    Colloids Surf B Biointerfaces 75:300-9. 2010
    ..A new procedure is proposed to examine the in vitro toxicity of nanoparticles in a more rigorous manner, which gives an improvement in the relationship between in vivo and in vitro toxicity studies...
  9. doi Effect of crowding by dextrans on the hydrolysis of N-Succinyl-L-phenyl-Ala-p-nitroanilide catalyzed by α-chymotrypsin
    Isabel Pastor
    Department of Physical Chemistry, University of Barcelona UB, Barcelona, Spain
    J Phys Chem B 115:1115-21. 2011
    ..rates of the hydrolysis of N-succinyl-L-phenyl-Ala-p-nitroanilide catalyzed by α-chymotrypsin, by adding dextrans of various molecular weights to the reaction solutions...
  10. pmc Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis
    Dimitrios Karussis
    Department of Neurology, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem IL 91120, Israel
    Arch Neurol 67:1187-94. 2010
    ....
  11. doi Magnetic resonance imaging overestimates ferumoxide-labeled stem cell survival after transplantation in the heart
    John Terrovitis
    Johns Hopkins University, Division of Cardiology, Department of Medicine, Rutland Ave, Baltimore, MD 21205, USA
    Circulation 117:1555-62. 2008
    ..We sought to determine the relationship between the persistence of iron-dependent MRI signals and cell survival 3 weeks after injection of syngeneic or xenogeneic ferumoxides-labeled stem cells (cardiac-derived stem cells) in rats...
  12. ncbi Factors regulating macrophage endocytosis of nanoparticles: implications for targeted magnetic resonance plaque imaging
    Walter J Rogers
    Department of Radiology, University of Virginia Health System, 409 Lee Street Box 801339, Charlottesville, VA 22908, USA
    Atherosclerosis 178:67-73. 2005
    ..We describe the extent to which endogenous and exogenous factors regulate Mphi uptake of SPIO particles...
  13. doi Encapsulation of superparamagnetic nanoparticles into red blood cells as new carriers of MRI contrast agents
    Antonella Antonelli
    Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino PU, Italy
    Nanomedicine (Lond) 6:211-23. 2011
    ..In this article, we report the encapsulation of different magnetic nanoparticles into human erythrocytes to increase their blood circulation time...
  14. pmc A phase 2 study of (99m)Tc-tilmanocept in the detection of sentinel lymph nodes in melanoma and breast cancer
    Stanley P L Leong
    California Pacific Medical Center and Sutter Pacific Medical Foundation and Research Institute, University of California, San Francisco, CA, USA
    Ann Surg Oncol 18:961-9. 2011
    ..This novel molecular species provides the basis for potentially enhanced SLN mapping reliability...
  15. ncbi Chondrogenic differentiation of mesenchymal stem cells is inhibited after magnetic labeling with ferumoxides
    Jeff W M Bulte
    Blood 104:3410-2; author reply 3412-3. 2004
  16. pmc A receptor-targeted fluorescent radiopharmaceutical for multireporter sentinel lymph node imaging
    Derek K Emerson
    Moores UCSD Cancer Center, Department of Radiology, Department of Surgery, and UCSD In Vivo Cancer and Molecular Imaging Center, University of California, San Diego, 3855 Health Sciences Dr, La Jolla, CA 92093
    Radiology 265:186-93. 2012
    ..To determine the imaging and receptor-binding properties of a multireporter probe designed for sentinel lymph node (SLN) mapping via nuclear and fluorescence detection...
  17. ncbi Lymphoseek: a molecular radiopharmaceutical for sentinel node detection
    Anne M Wallace
    Department of Surgery, University of California, San Diego Comprehensive Cancer Center, USA
    Ann Surg Oncol 10:531-8. 2003
    ..We conducted a phase I clinical trial in which Lymphoseek was compared with filtered [(99m)Tc]sulfur colloid (fTcSC) for sentinel node detection in patients with breast cancer...
  18. doi In vivo mononuclear cell tracking using superparamagnetic particles of iron oxide: feasibility and safety in humans
    Jennifer M J Richards
    Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Circ Cardiovasc Imaging 5:509-17. 2012
    ....
  19. doi Simulation and experimental studies on magnetic hyperthermia with use of superparamagnetic iron oxide nanoparticles
    Kenya Murase
    Division of Medical Technology and Science, Faculty of Health Science, Department of Medical Physics and Engineering, Graduate School of Medicine, Osaka University, 1 7 Yamadaoka, Suita, Osaka, Japan
    Radiol Phys Technol 4:194-202. 2011
    ..There was a tendency for the temperature rise to saturate with increasing f. In conclusion, this study will be useful for investigating the feasibility of MH with Resovist® and optimizing the parameters for it...
  20. doi Dynamic colocalization microscopy to characterize intracellular trafficking of nanomedicines
    Dries Vercauteren
    Laboratory of General Biochemistry and Physical Pharmacy, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    ACS Nano 5:7874-84. 2011
    ..Colocalization of polyplexes with the autophagy marker LC3 suggests for the first time that the process of xenophagy could play an important role in the persistent endosomal entrapment of nanomedicines...
  21. pmc Ultrasmall superparamagnetic iron oxides (USPIOs): a future alternative magnetic resonance (MR) contrast agent for patients at risk for nephrogenic systemic fibrosis (NSF)?
    Edward A Neuwelt
    Department of Neurology and Neurosurgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    Kidney Int 75:465-74. 2009
    ..We conclude that for both CNS MR imaging and MR angiography, USPIO agents like ferumoxytol are a viable option for patients at risk for NSF...
  22. pmc Surgical wound healing using hemostatic gauze scaffold loaded with nanoparticles containing sustained-release granulocyte colony-stimulating factor
    Weien Yuan
    Department of Neurology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China
    Int J Nanomedicine 6:3139-49. 2011
    ....
  23. doi Dextran-doxorubicin/chitosan nanoparticles for solid tumor therapy
    Savita Bisht
    Department of Chemistry, University of Delhi, Delhi, India
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 1:415-25. 2009
    ..The cardiotoxicity of doxorubicin can be minimized by coupling the drug with dextran and encapsulating it in chitosan nanoparticles...
  24. ncbi Comparison of three fluid solutions for resuscitation in dengue shock syndrome
    Bridget A Wills
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 353:877-89. 2005
    ..Although volume replacement is recognized as the critical therapeutic intervention, World Health Organization management guidelines remain empirical rather than evidence-based...
  25. doi Synthesis and antitumor activity of stearate-g-dextran micelles for intracellular doxorubicin delivery
    Yong Zhong Du
    College of Pharmaceutical Sciences, Zhejiang University, 388 Yuhangtang Road, Hangzhou 310058, P R China
    ACS Nano 4:6894-902. 2010
    ..In vivo antitumor activity results showed that Dex-SA/DOX micelles treatments effectively suppressed the tumor growth and reduced the toxicity against animal body compared with commercial doxorubicin injection...
  26. ncbi Capacity of human monocytes to phagocytose approved iron oxide MR contrast agents in vitro
    Stephan Metz
    Department of Diagnostic Radiology, Technical University Munich, Munich, Germany
    Eur Radiol 14:1851-8. 2004
    ..In vitro labeling of human monocytes for MR imaging is most effectively obtained with the approved SPIO Ferucarbotran. Potential subsequent in vivo cell tracking applications comprise, e.g. specific targeting of inflammatory processes...
  27. ncbi Identifying inflamed carotid plaques using in vivo USPIO-enhanced MR imaging to label plaque macrophages
    Rikin A Trivedi
    University Department of Radiology, Addenbrooke s Hospital, Cambridge, UK
    Arterioscler Thromb Vasc Biol 26:1601-6. 2006
    ..We set out to evaluate the use of a macrophage labeling agent to identify carotid plaque inflammation by in vivo magnetic resonance imaging (MRI)...
  28. pmc The influence of ferucarbotran on the chondrogenesis of human mesenchymal stem cells
    Tobias D Henning
    Department of Radiology, UCSF Medical Center, University of California, San Francisco, CA 94143 0628, USA
    Contrast Media Mol Imaging 4:165-73. 2009
    ..Magnetic labeling of hMSC with ferucarbotran inhibits chondrogenesis in a dose-dependent manner when using simple incubation techniques. When decreasing the incubation time to 4 h, inhibition of chondrogenesis was not significant...
  29. doi Highly specific dual enzyme-mediated payload release from peptide-coated silica particles
    Paul D Thornton
    School of Chemical Sciences, Dublin City University, Dublin 9, Ireland
    J Am Chem Soc 132:2024-8. 2010
    ..Specific enzymatic hydrolysis of the peptide shell removes the bulky peptide-terminated Fmoc groups, permitting the selective release of previously entrapped guest molecules...
  30. ncbi Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution
    C Chouly
    Laboratoire de Biophysique, Faculte de Medecine, Angers, France
    J Microencapsul 13:245-55. 1996
    ..It was up to 3 X lower for electrically neutral particles than for charged particles. Coated particles presented higher vascular persistence. The diagnostic potential for liver, lymph node or vascular imaging were discussed...
  31. ncbi A model of lysosomal metabolism of dextran coated superparamagnetic iron oxide (SPIO) nanoparticles: implications for cellular magnetic resonance imaging
    Ali S Arbab
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, Maryland, USA
    NMR Biomed 18:383-9. 2005
    ..The studies presented represent a first step in identifying the important cellular environmental parameters affecting the integrity of FE-TA complexes...
  32. ncbi Macrophage endocytosis of superparamagnetic iron oxide nanoparticles: mechanisms and comparison of ferumoxides and ferumoxtran-10
    Isabelle Raynal
    Guerbet Research Department, Roissy CDG Cedex, France
    Invest Radiol 39:56-63. 2004
    ....
  33. ncbi Intraocular distribution of 70-kDa dextran after subconjunctival injection in mice
    Tae Woo Kim
    Glaucoma Center, University of California San Diego, La Jolla, California 9209 0946, USA
    Invest Ophthalmol Vis Sci 43:1809-16. 2002
    ..To investigate the intraocular distribution kinetics of 70-kDa dextran after subconjunctival injection...
  34. ncbi Real-time imaging of convection-enhanced delivery of viruses and virus-sized particles
    Nicholas J Szerlip
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 107:560-7. 2007
    ....
  35. doi Labeling of human mesenchymal stromal cells with superparamagnetic iron oxide leads to a decrease in migration capacity and colony formation ability
    Richard SchAfer
    Institute of Clinical and Experimental Transfusion Medicine, University Hospital Tubingen, Germany
    Cytotherapy 11:68-78. 2009
    ....
  36. doi A half century of experimental neuroanatomical tracing
    Jose L Lanciego
    Center for Applied Medical Research CIMA and CIBERNED, Neurosciences, Basal Ganglia Laboratory, University of Navarra, Pio XII Ave 55 Edificio CIMA, 31008 Pamplona, Navarra, Spain
    J Chem Neuroanat 42:157-83. 2011
    ....
  37. ncbi Preparation of dextran glassy particles through freezing-induced phase separation
    Weien Yuan
    Shanghai JiaoTong University School of Pharmacy, 800 Dongchuan Road, Shanghai 200240, China
    Int J Pharm 339:76-83. 2007
    ..This particulate system and its forming process may have wide applications in formulating variety of pharmaceutical dosage forms and medical devices containing delicate biotech therapeutics...
  38. doi Development of protein delivery microsphere system by a novel S/O/O/W multi-emulsion
    Weien Yuan
    Shanghai Jiaotong University, School of Pharmacy, 800 Dongchuan Road, Shanghai 200240, People s Republic of China
    Eur J Pharm Sci 36:212-8. 2009
    ..The dextran glassy particles can stabilize proteins in the PLGA matrix, which is the major advantage of this novel protein sustained-release system over preparation for the PLGA microspheres using W/O/W double-emulsion method...
  39. ncbi Effect of human stem cells labeled with ferumoxides-poly-L-lysine on hematologic and biochemical measurements in rats
    Gene T Yocum
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Radiology 235:547-52. 2005
    ....
  40. ncbi A novel approach with magnetic resonance imaging used for the detection of lung allograft rejection
    S Kanno
    Department of Biological Sciences and Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, and the Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    J Thorac Cardiovasc Surg 120:923-34. 2000
    ..Although various techniques have been explored for the detection and quantification of allograft transplant rejection, a practical and reliable method that is noninvasive is still elusive...
  41. doi The promotion of human mesenchymal stem cell proliferation by superparamagnetic iron oxide nanoparticles
    Dong Ming Huang
    Center for Nanomedicine Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli 350, Taiwan
    Biomaterials 30:3645-51. 2009
    ..Also, Ferucarbotran can accelerate cell cycle progression, which may be mediated by the free iron (Fe) released from lysosomal degradation and involves the alteration of Fe on the expression of the protein regulators of the cell cycle...
  42. doi Blood-brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE
    Jami Bennett
    University of British Columbia, Biomedical Research Centre, Vancouver, British Columbia, Canada
    J Neuroimmunol 229:180-91. 2010
    ....
  43. ncbi New patterns of intracortical projections after focal cortical stroke
    S T Carmichael
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neurobiol Dis 8:910-22. 2001
    ..Thus, after focal cortical stroke, the peri-infarct cortex is structurally abnormal, loses thalamic connections, and develops new horizontal cortical connections by axonal sprouting...
  44. doi Resuscitation with hypertonic saline-dextran reduces serum biomarker levels and correlates with outcome in severe traumatic brain injury patients
    Andrew J Baker
    Brain Injury Laboratory, Cara Phelan Centre for Trauma Research, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Neurotrauma 26:1227-40. 2009
    ..Pre-hospital resuscitation with HSD is associated with a reduction in serum S100B, NSE, and MBP concentrations, which are correlated with better outcome after severe TBI...
  45. ncbi Preparation of magnetically labeled cells for cell tracking by magnetic resonance imaging
    Jeff W M Bulte
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Methods Enzymol 386:275-99. 2004
  46. doi Effects of iron oxide incorporation for long term cell tracking on MSC differentiation in vitro and in vivo
    Eric Farrell
    Department of Orthopaedics, Erasmus MC, University Medical Centre, Room Ee1651a, Dr Molewaterplein 50, 3015GE Rotterdam, The Netherlands
    Biochem Biophys Res Commun 369:1076-81. 2008
    ..This study demonstrates long term MSC traceability using SPIO and MRI, uninhibited multilineage MSC differentiation following SPIO labeling, though with subtle but significant phenotypical alterations...
  47. ncbi MRI of transplanted pancreatic islets
    Daniel Jirak
    Department of Radiodiagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Magn Reson Med 52:1228-33. 2004
    ..This study, therefore, represents a promising step toward possible clinical application in human medicine...
  48. pmc Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O
    I Walev
    Institute of Medical Microbiology and Hygiene, Johannes Gutenberg University, 55101 Mainz, Germany
    Proc Natl Acad Sci U S A 98:3185-90. 2001
    ..botulinum C2-toxin resulted in enhanced secretion in cells. The presented method for introducing proteins into living cells should find multifaceted application in cell biology...
  49. pmc Physicochemical characterization of ultrasmall superparamagnetic iron oxide particles (USPIO) for biomedical application as MRI contrast agents
    Mariagrazia Di Marco
    Univ Paris Sud, Chatenay Malabry, France
    Int J Nanomedicine 2:609-22. 2007
    ..An extended characterization is therefore necessary to improve the understanding of the properties of USPIOs when dispersed in an aqueous environment and to set the specifications and limits for their conception...
  50. pmc Comparison of reporter gene and iron particle labeling for tracking fate of human embryonic stem cells and differentiated endothelial cells in living subjects
    Zongjin Li
    Department of Radiology and Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California 94305 5344, USA
    Stem Cells 26:864-73. 2008
    ..Furthermore, transplantation of predifferentiated rather than undifferentiated hES cells would be more suited for avoiding teratoma formation...
  51. ncbi Synthesis of ultrasmall superparamagnetic iron oxides using reduced polysaccharides
    Kenneth G Paul
    Advanced Magnetics, Inc, 61 Mooney Street, Cambridge, Massachusetts 02138 1038, USA
    Bioconjug Chem 15:394-401. 2004
    ..weight of the reduced polysaccharide has on particle synthesis; and (iv) the effectiveness of reduced and native dextrans in stabilizing a preformed magnetic sol...
  52. ncbi Effect of crowding by dextrans and Ficolls on the rate of alkaline phosphatase-catalyzed hydrolysis: a size-dependent investigation
    L Homchaudhuri
    Department of Chemistry, Indian Institute of Technology Guwahati, North Guwahati, Guwahati 781039, Assam, India
    Biopolymers 83:477-86. 2006
    ..of different sizes, shapes, and concentrations? Here, we mimic the cytosolic crowding in vitro, using dextrans and Ficolls, for the first time in a variety of sizes ranging from 15 to 500 kDa, in a concentration range 0-30% ..
  53. doi Neuroprotective effects and magnetic resonance imaging of mesenchymal stem cells labeled with SPION in a rat model of Huntington's disease
    Louise Moraes
    Centro de Ciencias da Saude, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil
    Stem Cell Res 9:143-55. 2012
    ..Our data highlight the potential of adult MSC to reduce brain damage under neurodegenerative diseases and indicate the use of nanoparticles in cell tracking, supporting their potential as valuable tools for cell therapy...
  54. pmc Contralesional axonal remodeling of the corticospinal system in adult rats after stroke and bone marrow stromal cell treatment
    Zhongwu Liu
    Neurology Research, E and R Building, Room 3056, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA
    Stroke 39:2571-7. 2008
    ..We investigated contralesional corticospinal tract remodeling in the brain and spinal cord in rats after stroke and treatment of bone marrow stromal cells...
  55. ncbi Rat intralaminar thalamic nuclei projections to the globus pallidus: a biotinylated dextran amine anterograde tracing study
    T Yasukawa
    Department of Anatomy and Neurobiology, College of Medicine, The University of Tennessee Memphis, Memphis, Tennessee 38163, USA
    J Comp Neurol 471:153-67. 2004
    ..Thus, each part of the ITN projecting to the sensorimotor, the association, and the limbic territories of the Str also projects to the corresponding functional territories of the GP...
  56. pmc Fast 18F labeling of a near-infrared fluorophore enables positron emission tomography and optical imaging of sentinel lymph nodes
    Richard Ting
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093, USA
    Bioconjug Chem 21:1811-9. 2010
    ..Facile incorporation of (18)F into a NIRF probe should promote many synergistic PET and NIRF combinations...
  57. ncbi Quantification of breast tumor microvascular permeability with feruglose-enhanced MR imaging: initial phase II multicenter trial
    Heike E Daldrup-Link
    Dept of Radiology, Univ Hosp, Technical Univ of Munich, Ismaningerstr 22, 81675 Munich, Germany
    Radiology 229:885-92. 2003
    ..To investigate use of the macromolecular contrast agent feruglose for differentiating and grading of human benign and malignant breast tumors on the basis of their microvascular characteristics...
  58. ncbi Superparamagnetic iron oxide labeling and transplantation of adipose-derived stem cells in middle cerebral artery occlusion-injured mice
    Henry E Rice
    Department of Surgery, Duke University Medical Center, Box 3815, Durham, NC 27710, USA
    AJR Am J Roentgenol 188:1101-8. 2007
    ..We hypothesized that we would successfully label adipose-derived stem cells and image them with MRI...
  59. doi A metabonomic analysis of organ specific response to USPIO administration
    Jianghua Feng
    Department of Electronic Science, Fujian Key Laboratory of Plasma and Magnetic Resonance, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005, China
    Biomaterials 32:6558-69. 2011
    ..Such a metabonomic strategy provides methodology for investigating the potential adverse biological effects of similar nanoparticles on the environmental and human health and assessing the drug interventions on the targeted organ...
  60. ncbi Fireworks in the primate retina: in vitro photodynamics reveals diverse LGN-projecting ganglion cell types
    Dennis M Dacey
    Department of Biological Structure, University of Washington, Seattle, WA 98175, USA
    Neuron 37:15-27. 2003
    ..Cells could also be targeted in vitro for intracellular recording and physiological analysis. The photodynamic process was also observed in pyramidal cells in a rat neocortical slice...
  61. doi Validation of in vitro cell culture models of the blood-brain barrier: tightness characterization of two promising cell lines
    Winfried Neuhaus
    Department of Medicinal Chemistry, University of Vienna, Pharmacy Center, Althanstrasse 14, A 1090 Vienna, Austria
    J Pharm Sci 97:5158-75. 2008
    ..Cell line ECV304 seemed to be suitable for TEER dependent transport studies, whereas PBMEC/C1-2 showed higher potential for P-gP studies...
  62. ncbi MR evaluation of the glomerular homing of magnetically labeled mesenchymal stem cells in a rat model of nephropathy
    Olivier Hauger
    Department of Radiology and Radiological Sciences, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Radiology 238:200-10. 2006
    ..To assess renal glomerular homing of intravenously injected superparamagnetic iron oxide (SPIO)-labeled mesenchymal stem cells (MSCs) at in vivo and ex vivo magnetic resonance (MR) imaging in an experimental rat model of mesangiolysis...
  63. ncbi Superparamagnetic iron oxide-enhanced magnetic resonance imaging of neuroinflammation in a rat model of radicular pain
    Daniel L J Thorek
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Imaging 10:206-14. 2011
    ..These findings suggest that SPIO-enhanced MRI may be a valuable tool to identify otherwise undetectable nerve root compression and enable improved patient management...
  64. pmc Labeling stem cells with superparamagnetic iron oxide nanoparticles: analysis of the labeling efficacy by microscopy and magnetic resonance imaging
    - Jasmin
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Methods Mol Biol 906:239-52. 2012
    ..g., protamine) are currently the preferred materials for cell labeling and tracking. Here we describe how to use superparamagnetic iron oxide nanoparticles to label cells and to monitor cell fate in several disease models...
  65. doi Preoperative sentinel lymph node mapping of the prostate using PET/CT fusion imaging and Ga-68-labeled tilmanocept in an animal model
    Sean P Stroup
    Division of Urology, Department of Surgery, UCSD Moores Cancer Center, University of California, San Diego, CA, USA
    Clin Exp Metastasis 29:673-80. 2012
    ..Gallium-68-labaled tilmanocept was highly specific for sentinel nodes. Image-guided tumor resection and lymphadenectomy may become a promising future application in urologic oncology and warrants further investigation...
  66. pmc Combined analysis of phase III trials evaluating [⁹⁹mTc]tilmanocept and vital blue dye for identification of sentinel lymph nodes in clinically node-negative cutaneous melanoma
    Vernon K Sondak
    H Lee Moffitt Cancer Center, Tampa, FL, USA
    Ann Surg Oncol 20:680-8. 2013
    ..99m)Tc]Tilmanocept is a CD206 receptor-targeted radiopharmaceutical designed for sentinel lymph node (SLN) identification. Two nearly identical nonrandomized phase III trials compared [(99m)Tc]tilmanocept to vital blue dye...
  67. ncbi MR contrast in mouse lymph nodes with subcutaneous administration of iron oxide particles: size dependency
    Yuki Mori
    Biofunctional Imaging Laboratory, Immunology Frontier Research Center, Annex 1F, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan
    Magn Reson Med Sci 10:219-27. 2011
    ..We investigated the spatiotemporal changes in signal in draining lymph nodes of mice to ascertain the size-dependent effects of variously sized particles of iron oxide used to enhance magnetic resonance (MR) lymphography...
  68. ncbi Influence of molecular weight on intracameral dextran movement to the posterior segment of the mouse eye
    Antje S Bernd
    Hamilton Glaucoma Center and Department of Ophthalmology, University of California San Diego, La Jolla, California 92093, USA
    Invest Ophthalmol Vis Sci 45:480-4. 2004
    ..In this study, the influence of molecular weight on the intraocular distribution of dextran molecules after intracameral injection in the mouse eye was investigated...
  69. doi Intravital microscopy at the single vessel level brings new insights of vascular modification mechanisms induced by electropermeabilization
    Elisabeth Bellard
    CNRS, Institut de Pharmacologie et de Biologie Structurale, BP 64182, 205 route de Narbonne, F 31077, Toulouse, France
    J Control Release 163:396-403. 2012
    ..These features were measured in C57Bl/6 mice via a dorsal skin fold window chamber, using fluorescently labeled dextrans of different sizes, intravital fluorescence microscopy imaging and specific image analysis...
  70. doi Can we accurately quantify nanoparticle associated proteins when constructing high-affinity MRI molecular imaging probes?
    Gabriella Rimkus
    Institute of Diagnostic and Interventional Radiology, University Hospital Jena, Germany
    Contrast Media Mol Imaging 6:119-25. 2011
    ..Additionally, the present protein coupling procedures can be drastically improved by our proposed protein quantification method...
  71. pmc Membrane disruption: an early event of hair cell apoptosis induced by exposure to intense noise
    Bo Hua Hu
    Center for Hearing and Deafness, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Brain Res 1239:107-18. 2008
    ..damage was assessed functionally, using membrane tracers with graded molecular sizes (propidium iodide and FITC-dextrans with molecular sizes of 3, 40, 500, and 2000 kDa), and morphologically, using DiO staining and semithin sections...
  72. doi Intraspinal rewiring of the corticospinal tract requires target-derived brain-derived neurotrophic factor and compensates lost function after brain injury
    Masaki Ueno
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Brain 135:1253-67. 2012
    ..Our findings establish the anatomical, functional and molecular basis for the intrinsic capacity of neurons to form compensatory neural network following injury...
  73. doi Preparing polymer-based sustained-release systems without exposing proteins to water-oil or water-air interfaces and cross-linking reagents
    Tuo Jin
    Shanghai JiaoTong University School of Pharmacy, China
    J Control Release 128:50-9. 2008
    ....
  74. pmc Complex comprised of dextran magnetite and conjugated cisplatin exhibiting selective hyperthermic and controlled-release potential
    Akinaga Sonoda
    Department of Radiology, Shiga University of Medical Science, Setatsukinowa cho, Otsu, Shiga, 520 2192, Japan
    Int J Nanomedicine 5:499-504. 2010
    ..The temperature in muscle tissue registered a maximum of 56°C after about 4 min. DM-Cis may represent a magnetically-accumulated anticancer drug with hyperthermic effects...
  75. doi Optimizing the deswelling process of organ-cultured corneas
    Armin H Wolf
    Department of Ophthalmology, Ludwig Maximilians Universitat, Muenchen, Germany
    Cornea 28:524-9. 2009
    ..We investigated the minimal deswelling time necessary and analyzed endothelial cell loss...
  76. doi Abdominal aortic aneurysm growth predicted by uptake of ultrasmall superparamagnetic particles of iron oxide: a pilot study
    Jennifer M J Richards
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Circ Cardiovasc Imaging 4:274-81. 2011
    ..Using MRI, we aimed to assess whether areas of cellular inflammation correlated with the rate of abdominal aortic aneurysm expansion...
  77. ncbi Gadolinium-DTPA-dextran: a macromolecular MR blood pool contrast agent
    Claude B Sirlin
    Department of Radiology, University of California, San Diego, 200 West Arbor Drive, San Diego, CA, USA
    Acad Radiol 11:1361-9. 2004
    ..The purpose of this study was to test gadolinium-diethylenetriaminepentaacetate-dextran ([Gd]DTPA-dextran) as a new water soluble macromolecular blood pool agent for MR imaging...
  78. pmc In vivo ocular fluorophotometry: delivery of fluoresceinated dextrans via transscleral diffusion in rabbits
    Damian E Berezovsky
    Department of Ophthalmology, Emory University, Atlanta, Georgia 30322, USA
    Invest Ophthalmol Vis Sci 52:7038-45. 2011
    To evaluate the transscleral delivery of fluoresceinated dextrans (FITC-D) with molecular mass up to 70 kDa to the rabbit posterior segment using sub-Tenon injections.
  79. doi Assessment of macrophage infiltration in a murine model of abdominal aortic aneurysm
    Gregory H Turner
    Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline, King of Prussia, Pennsylvania, USA
    J Magn Reson Imaging 30:455-60. 2009
    ..To evaluate the use of an ultrasmall superparamagnetic iron oxide (USPIO) contrast agent as a marker for the detection of macrophage in a preclinical abdominal aortic aneurysm animal (AAA) model...
  80. pmc In vivo molecular imaging and histological analysis of changes induced by electric pulses used for plasmid DNA electrotransfer to the skin: a study in a dorsal window chamber in mice
    Bostjan Markelc
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, 1000 Ljubljana, Slovenia
    J Membr Biol 245:545-54. 2012
    ..Therefore, using intravital microscopy in a dorsal window chamber in mice and fluorescently labeled dextrans, the effects of one HV and eight LV pulses on skin vasculature were investigated...
  81. pmc Sentinel lymph node accumulation of Lymphoseek and Tc-99m-sulfur colloid using a "2-day" protocol
    Anne M Wallace
    Department of Surgery, University of California, San Diego, CA 92103, USA Moores UCSD Cancer Center, University of California, La Jolla, CA 92093, USA
    Nucl Med Biol 36:687-92. 2009
    ..5+/-3.1%) was statistically equivalent (P=.213). When an intradermal injection is employed, Lymphoseek demonstrated faster injection site clearance than unfiltered [(99m)Tc]sulfur colloid and persistent SLN accumulation for at least 24 h...
  82. ncbi Instant MR labeling of stem cells using magnetoelectroporation
    P Walczak
    Russell H Morgan Department of Radiology and Radiological Science, MR Research Division, and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Magn Reson Med 54:769-74. 2005
    ..As MEP circumvents the use of secondary agents, obviating the need for clinical approval, MEP labeling may be ideally suitable for bedside implementation...
  83. pmc Sentinel lymph node mapping of breast cancer via intradermal administration of Lymphoseek
    Anne M Wallace
    Department of Surgery, Moores UCSD Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
    Nucl Med Biol 34:849-53. 2007
    ..7 h for fTcSC. The mean SLN uptake of Lymphoseek (1.1+/-.5%) and fTcSC (2.5+/-4.9%) was statistically equivalent (P=.28). When an intra dermal injection was employed, Lymphoseek demonstrated faster injection site clearance than fTcSC...
  84. ncbi Dextran-spermine polycation: an efficient nonviral vector for in vitro and in vivo gene transfection
    H Hosseinkhani
    Department of Biomaterials, Field of Tissue Engineering, Kyoto University, Kyoto, Japan
    Gene Ther 11:194-203. 2004
    ..This work offers a new biodegradable polycation based on natural components, which is capable of transfecting cells and tissues in vitro and in vivo...
  85. doi Kinetics of retinal vaso-obliteration and neovascularisation in the oxygen-induced retinopathy (OIR) mouse model
    C Lange
    Laboratory for Cell Biology, University Eye Hospital, 79106 Freiburg, Germany
    Graefes Arch Clin Exp Ophthalmol 247:1205-11. 2009
    ....
  86. doi Effects of glucose toxicity and islet purity on in vivo magnetic resonance imaging of transplanted pancreatic islets
    Natalia V Evgenov
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Transplantation 85:1091-8. 2008
    ..To fully interpret the imaging data, it is critical to investigate factors normally present during clinical transplantation and influencing MRI of transplanted islets...
  87. ncbi Budding and asymmetric protein microcompartmentation in giant vesicles containing two aqueous phases
    M Scott Long
    Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Am Chem Soc 130:756-62. 2008
    ..Budding in ATPS-containing GVs thus offers an experimental model system for investigating the effects of biochemical asymmetry on the length scale of single cells...
  88. doi Preparation of polysaccharide glassy microparticles with stabilization of proteins
    Weien Yuan
    Shanghai Jiaotong University, School of Pharmacy, Shanghai, 200240, China
    Int J Pharm 366:154-9. 2009
    ....
  89. doi MR imaging of iron phagocytosis in intraluminal thrombi of abdominal aortic aneurysms in humans
    Alain Nchimi
    Departments of Medical Imaging and Pathology, Centre Hospitalier Chrétien, rue de Hesbaye, 75, B 4000 Liege, Belgium
    Radiology 254:973-81. 2010
    ..To prospectively determine if superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging could help visualize leukocyte phagocytic activities in human abdominal aortic aneurysms (AAAs)...
  90. ncbi Reticular premotor neurons projecting to both facial and hypoglossal nuclei receive trigeminal afferents in rats
    C Dauvergne
    , EA3107, UP7, 2 place Jussieu, Case 7077, 75251 Cedex 05, Paris, France
    Neurosci Lett 311:109-12. 2001
    ..These neurons were mainly encountered ventral to the trigeminal motor nucleus and dorsal to the VII. Functionally, this region is known to be involved in eye protection mechanisms...
  91. ncbi Trigemino-reticulo-facial and trigemino-reticulo-hypoglossal pathways in the rat
    F Zerari-Mailly
    Laboratoire de Neuroanatomie Fonctionnelle des Systèmes Sensorimoteurs, 75251 Paris Cedex 05, France
    J Comp Neurol 429:80-93. 2001
    ..These experiments demonstrate the existence of trigeminal disynaptic influences, via reticular neurons of the pontomedullary reticular formation, in the control of orofacial motor behaviors...
  92. doi Magnetic resonance imaging and biological properties of pancreatic islets labeled with iron oxide nanoparticles
    Hoe Suk Kim
    Diagnostic Radiology, Seoul National University Hospital, Institute of Radiation Medicine, Medical Research Center, Seoul National University, 28, Yeongeon Dong, Jongno gu, Seoul 110 744, Republic of Korea
    NMR Biomed 22:852-6. 2009
    ..67 +/- 0.15 fold vs. unlabeled; p = 0.029). The findings of this study indicate that Resovist provides a satisfactory means to image islets and has no deleterious effect on islet function or gene expression...
  93. ncbi The in vitro effects of a bimodal contrast agent on cellular functions and relaxometry
    Cecilie Brekke
    NeuroImaging Research Group Department of Neurology, Institute of Psychiatry, King s College London, UK
    NMR Biomed 20:77-89. 2007
    ..Further in vivo testing will be required to ensure that cell labeling with gadolinium-based MRI contrast agents does not impair their ability to repair...
  94. ncbi Doxorubicin release from core-shell type nanoparticles of poly(DL-lactide-co-glycolide)-grafted dextran
    Young Il Jeong
    The Research Institute of Medical Sciences, Chonnam National University, Gwangju, Korea
    Arch Pharm Res 29:712-9. 2006
    ..Core-shell type nanoparticles of DexLG copolymer can be used as a colonic drug carrier. In conclusion, size, morphology, and molecular structure of DexLG nanoparticles are available to consider as an oral drug targeting nanoparticles...
  95. doi Semiquantitation of mouse dendritic cell migration in vivo using cellular MRI
    Gregory A Dekaban
    BioTherapeutics Research Group, University of Western Ontario, London, Ontario, Canada
    J Immunother 32:240-51. 2009
    ..These findings, together with ongoing preclinical studies, are key to gaining information critical for improving the efficacy of therapeutic vaccines for the treatment cancer, and potentially, chronic infectious diseases...
  96. ncbi Dextrans for targeted and sustained delivery of therapeutic and imaging agents
    R Mehvar
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, TX 79106, USA
    J Control Release 69:1-25. 2000
    b>Dextrans are glucose polymers which have been used for more than 50 years as plasma volume expanders. Recently, however, dextrans have been investigated for delivery of drugs, proteins/enzymes, and imaging agents...
  97. ncbi Paclitaxel delivery systems: the use of amino acid linkers in the conjugation of paclitaxel with carboxymethyldextran to create prodrugs
    Shu ichi Sugahara
    The Second Research Department of Central Technology Laboratory, AsahiKasei Corporation, Fuji, Shizuoka, Japan
    Biol Pharm Bull 25:632-41. 2002
    ....
  98. ncbi Magnetic resonance imaging tracking of human adipose derived stromal cells within three-dimensional scaffolds for bone tissue engineering
    C Lalande
    Universite Bordeaux, Bordeaux, France
    Eur Cell Mater 21:341-54. 2011
    ..In addition, the present findings evidenced that MRI is a reliable technique to validate cell-seeding procedures in 3D porous scaffolds, and to assess the fate of hADSCs transplanted in vivo...
  99. doi The inhibitory effect of superparamagnetic iron oxide nanoparticle (Ferucarbotran) on osteogenic differentiation and its signaling mechanism in human mesenchymal stem cells
    Ying Chun Chen
    Center for Nanomedicine Research, National Health Research Institutes, Zhunan, Miaoli County 350, Taiwan
    Toxicol Appl Pharmacol 245:272-9. 2010
    ....
  100. ncbi Comparison of SPIO and USPIO for in vitro labeling of human monocytes: MR detection and cell function
    Raoul D Oude Engberink
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    Radiology 243:467-74. 2007
    ....
  101. pmc Comparison of optical bioluminescence reporter gene and superparamagnetic iron oxide MR contrast agent as cell markers for noninvasive imaging of cardiac cell transplantation
    Ian Y Chen
    Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA
    Mol Imaging Biol 11:178-87. 2009
    ....

Research Grants74

  1. Role of stearoyl CoA desaturase-1 in TLR5 KO mice colitis and metabolic syndrome
    Matam Vijay Kumar; Fiscal Year: 2013
    ..Overall, our research proposal may help in designing oleate-rich dietary formulations and also clarify whether SCD-1 can be targeted to prevent colitis and metabolic diseases ! ..
  2. Role of the kallikrein-kinin system in diabetic retinopathy
    Edward P Feener; Fiscal Year: 2012
    ..These studies could reveal new therapeutic strategies to treat diabetic macular edema, a leading cause of vision loss. ..
  3. EPIMORPHIN DELETION ALTERS STEM CELL NICHE MYOFIBROBLAST SECRETION
    Anisa Shaker; Fiscal Year: 2012
    ..These studies may provide the basis for novel therapeutic approaches to inflammatory bowel disease and CAC. ..
  4. Treatment of Inflammatory Bowel Disease with Ceramidase Inhibitors
    Lynn W Maines; Fiscal Year: 2012
    ..Extensive work, including our Preliminary Studies, suggests that inhibition of neutral ceramidase may provide a new therapy for these diseases. The proposed studies will provide the first test of this hypothesis. ..
  5. Liver disease in CF: CFTR controls innate immunity in biliary epithelium
    Mario Strazzabosco; Fiscal Year: 2013
    ..It has been shown that portal endotoxemia, induced by oral administration of dextrans specifically causes biliary damage in Cftr-KO mice, but not in their wild type littermates4...
  6. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
    ..We are developing a novel drug that specifically blocks the inflammatory process in this condition. We will test this agent in a series of clinically-relevant animal models of autoimmune colitis. ..
  7. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..Translation: Ap is an expedient marker to analyze aging effects on ISF-CSF relationships, and the compromised solute clearance by malfunctioning barrier systems. This sheds light on neurodegeneration. ..
  8. COMBINATORIAL-DESIGNED NANO-PLATFORMS TO OVERCOME TUMOR DRUG RESISTANCE
    Zhenfeng Duan; Fiscal Year: 2013
    ..and cytotoxic drugs for maximum cell-kill effect. ..
  9. Eotaxin in Colitis and Colitis-Associated Carcinogenesis
    Lori A Coburn; Fiscal Year: 2013
    ..These studies will provide new mechanistic insights into the role of eotaxin-1 in IBD and associated carcinogenesis. ..
  10. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith T Wilson; Fiscal Year: 2013
    ..Through investigation of epithelial and immune function, these studies seek to provide new macronutrient- based strategies for treatment of IBD and prevention of colitis-associated dysplasia and carcinoma. ..
  11. Development of the orally delivered, non-absorbable ACE inhibitor enalaprilat for
    ELKE LIPKA; Fiscal Year: 2010
    ..The goal is the development of a medicine with proven safety that can be easily taken by mouth both during a flare-up of the disease as well as a maintenance treatment. ..
  12. A Novel Colon-specific Bi-functional Amebicidal Therapeutics: Gal-Dextran-MM
    Jeoung Soo Lee; Fiscal Year: 2010
    ..This project is focused on development of a novel colon-specific bi-functional amebicidal therapeutic, Galactose-Dextran-Metronidazole (Gal-Dextran-MM) prodrug, for treatment of amebiasis. ..
  13. Neurotoxicity of Magnetic Nanoparticles
    Veronica Shubayev; Fiscal Year: 2010
    ....
  14. Regulation of colitis by orphan nuclear receptor Nur77
    Dezheng Zhao; Fiscal Year: 2013
    ..Our studies have high impact by linking Nur77 to IBD pathogenesis and indicate vascular components of inflammation that could serve as therapeutic targets. ..
  15. Probiotics-derived soluble proteins regulate intestinal inflammation
    Fang Yan; Fiscal Year: 2013
    ..Our long-term goal is to use p40 as a novel therapeutic agent for human intestinal inflammatory disorders. ..
  16. Role of STAT3 in the pathogenesis of Inflammatory Bowel Disease
    Prema Robinson; Fiscal Year: 2013
    ....
  17. Milk osteopontin, a nutritional therapeutic intervention for alcoholic hepatitis
    Natalia Nieto; Fiscal Year: 2013
    ....
  18. The Role of a Novel Vitamin E Metabolite in Colon Cancer Prevention and Therapy
    Qing Jiang; Fiscal Year: 2012
    ....
  19. Intercellular networks and luminal acidification in the male reproductive tract
    Sylvie Breton; Fiscal Year: 2013
    ..Data generated here will provide novel insights into the male reproductive tract in particular, as well as the physiology of acid/base transporting epithelia in general. ..
  20. Thoroughfare Channels in CBF Autoregulation at High ICP
    Edwin M Nemoto; Fiscal Year: 2009
    ....
  21. Molecular Mechanisms Regulating Intestinal Homeostasis
    Vincent W Yang; Fiscal Year: 2013
    ....
  22. Using vitamin D glucuronide pro-drugs to prevent/treat colon cancer
    JESSE PAUL GOFF; Fiscal Year: 2013
    ..The strength of the current proposal is the ability to target delivery of high concentrations of 1,25- dihydroxyvitamin D3 directly to the colon so its effects on colon carcinogenesis can be assessed in the absence of hypercalcemia. ..
  23. Therapeutic Evaluation of Magnetic Nanoprobes Specific for Malignant Tumor Marker
    Rheal A Towner; Fiscal Year: 2010
    ..Studying a potentially effective anti- tumor therapeutic agent, as well as developing novel in vivo diagnostic and predictive procedures may significantly impact patient prognosis and survivability in the future. ..
  24. Eosinophil Peroxidase in Allergic Inflammation
    Arne Slungaard; Fiscal Year: 2012
    ..If these studies succeed, we will have discovered a simple, cheap and safe way to treat allergies. ..
  25. Contribution of occludin to intestinal homeostasis and disease
    Le Shen; Fiscal Year: 2013
    ....
  26. Mechanisms of Cardiac Function and Cerebral Vascular Control during Heat Stress
    Robert Matthew Brothers; Fiscal Year: 2010
    ..g., car accident) in which an individual is profusely bleeding while at the same time their internal temperature is elevated. ..
  27. Mechanism of H. pylori-induced risk reduction for inflammatory bowel disease
    Jay Luther; Fiscal Year: 2009
    ..Furthermore, by elucidating the mechanism by which H. pylori does protect against IBD, insight can be gained into the development of more effective treatment for inflammatory bowel disease. ..
  28. Mitochrondrial Regulation of Apoptosis
    Tomomi Kuwana; Fiscal Year: 2013
    ..Mapping the distribution of Bax along the edge of the pores will enable us to determine whether Bax pores are mainly lipidic or proteinaceous. ..
  29. Role of Claudin-2 in Inflammatory Diseases and Colon Cancer
    Amar B Singh; Fiscal Year: 2013
    ....
  30. 15-LOX-1 effects on colitis and colon cancer
    Imad Shureiqi; Fiscal Year: 2012
    ..This improved understanding is expected to facilitate the identification of molecular targets for new strategies for colon cancer prevention. ..
  31. REGULATION OF INTESTINAL EPITHELIAL CELL PROLIFERATION
    Vincent W Yang; Fiscal Year: 2013
    ..The results may demonstrate that KLF5 is a potential therapeutic target for diseases with increased proliferation such as colon cancer. ..
  32. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin V Terry; Fiscal Year: 2013
    ..a water maze task to measure extinction (a form of cognitive flexibility) and stereotaxic injections of traceable dextrans, immunohistochemistry, and mass spectrometry to determine OP effects on axonal transport in the brain and the ..
  33. S1P Lyase in colon cancer
    Julie D Saba; Fiscal Year: 2013
    ..In accomplishing these aims, we should achieve our two major goals: to elucidate the biology of SPL in colon cancer, and to develop chemopreventive strategies that work by reactivation of SPL. ..
  34. Protease Pathways in the Gastrointestinal Tract
    Toni M Antalis; Fiscal Year: 2010
    ..abstract_text> ..
  35. Preclinical Efficacy And Safety Evaluation Of Graphene Nanoparticle-based Magneti
    Balaji Sitharaman; Fiscal Year: 2013
    ..The GNP-Dex could also due to their high-efficacy be used in clinic for other applications as an alternative off-the-label MRI CA to currently existing gadolinium-basedT1 MRI CAs. ..
  36. The role of HIF2alpha in colon carcinogenesis
    Yatrik M Shah; Fiscal Year: 2013
    ..Ultimately these studies will determine if HIF2a is a potential therapeutic target in colon inflammation and may provide an alternative strategy for preventing and treating colon cancer. ..
  37. Src Family Kinases and Control of Epithelial Cell Paracellular Permeability
    KURT F AMSLER; Fiscal Year: 2012
    ....
  38. Neuronal Somatic Response to Traumatic Brain Injury
    John T Povlishock; Fiscal Year: 2010
    ..of initial and continued somatic membrane change via the uptake of intrathecally administered fluorescent dextrans, will be followed over a 24h period...
  39. Study of bone disease in Thalassemia
    Maria G Vogiatzi; Fiscal Year: 2010
    ..These factors include the anemia itself and increased tissue iron. This study will also determine new medical regimens for the treatment of the bone disease in thalassemia. ..
  40. SUSCEPTIBILILTY GENE-VIRUS INTERACTIONS IN INFLAMMATORY BOWEL DISEASE
    Herbert W Virgin; Fiscal Year: 2013
    ....
  41. Detection of plaque based macrophages with light
    MARC DAVID FELDMAN; Fiscal Year: 2013
    ..These studies will also be performed in collaboration with the Nanotechnology Characterization Laboratory (see letter of support). ..
  42. Organization of the Cortical Projection to the Basal Ganglia
    ANTON J REINER; Fiscal Year: 2012
    ....
  43. Celecoxib Derivative: Host Cell-Directed Inhibitors of Intracellular Pathogens
    Kristy M Ainslie; Fiscal Year: 2013
    ..These studies will help to develop and characterize a new broad spectrum antibiotic and delivery platform that targets host cells. ..
  44. Functional Study of Mucin MUC1
    Sandra J Gendler; Fiscal Year: 2013
    ..Results from these studies should give us clearer insight into the role of MUC1 in the epithelium and hematopoietic system in both inflammation and cancer signaling pathways. ..
  45. Inducible colon-specific transgenic mouse for cancer research
    James C Fleet; Fiscal Year: 2013
    ..While our interests are in using this model for colon cancer, this model will also be useful for researchers interested in inflammatory conditions of the lower bowel (i.e. IBD, Crohn's disease). 1 ..
  46. Progranulin Intervention in Inflammatory Bowel Diseases
    Chuanju Liu; Fiscal Year: 2013
    ....
  47. The role of the primary cilium in glomerular podocyte cells
    ROBERT JOHN KOLB; Fiscal Year: 2012
    ..These studies will increase our understanding of basic kidney functions and provide a thorough functional assessment for a newly discovered podocyte organelle, as it relates podocyte based glomerular diseases. ..
  48. Encapsulated Active Vitamin D Vaccine for the Treatment of Multiple Sclerosis
    Kristy M Ainslie; Fiscal Year: 2012
    ..If successful, we will take the data generated in this grant and apply for an R01. In addition, our nanoparticle system could be applied to other autoimmune diseases such as Type 1 diabetes and rheumatoid arthritis. ..
  49. Epithelial-mesenchymal interactions in gut morphogenesis
    Deborah C Rubin; Fiscal Year: 2010
    ....
  50. Understanding the Role of N-WASP in the Intestinal Epithelium
    John Garber; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The overall goal of this proposal is to further our understanding of the mechanism(s) that regulate intestinal epithelial structure and enable it to perform its barrier function in both health and disease ..
  51. PATHOGENESIS OF FEVER IN HUMANS
    CHARLES ANTHONY DINARELLO; Fiscal Year: 2013
    ..The project seeks to understand how inflammation caused by cytokines is controlled. This information will result in a better understanding of disease severity and possibly new anti-inflammatory therapies. ..
  52. Multimodal nanoagents for the detection and treatment of atherosclerosis
    Jason R McCarthy; Fiscal Year: 2010
    ....
  53. Indoleamine 2,3 Dioxygenase in Colitis Associated Cancer
    MATTHEW AARON CIORBA; Fiscal Year: 2013
    ..The relevance of this work is to clarifying the potential role of therapeutic agents directed at affecting IDO activity in both colitis and malignancy of the colon. ..
  54. Colorectal cancer chemoprevention with phytochemical combinations
    Swati Nagar; Fiscal Year: 2013
    ..Data from the proposed aims will form the basis of future studies to evaluate additional metabolizing enzymes and transporters that are modulated by phytochemicals. ..
  55. Exploring the role of the central amygdala in vocalization
    IAN CHRISTOPHER HALL; Fiscal Year: 2013
    ....
  56. Engineering Multifunctional Nanoparticles
    Sangeeta N Bhatia; Fiscal Year: 2010
    ..The combination of these technologies and investigators is expected to lead to the development of a new generation of nanodevices that will significantly advance both medical science and treatment of cancer. ..
  57. MION for Synchronized MRI and Drug Therapy of Brain Tumor
    Victor C Yang; Fiscal Year: 2010
    ..In this new R01 application, we plan to confirm the utility of this DDS in vivo using well-established rat glioma models. ..
  58. IL-22 pathway in IBD
    Atsushi Mizoguchi; Fiscal Year: 2013
    ..2), how IL-22BP is constitutively expressed in normal colon (Aim 2.1), how IL-22BP expression is reduced under intestinal inflammatory condition (Aim 2.2), and how the reduction levels are further modified (Aim 2.2). ..
  59. The Role of BVES in Intestinal Repair Programs and Inflammatory Bowel Disease
    Bobak Parang; Fiscal Year: 2013
    ..Our proposed studies will define the role of BVES in IBD pathology and injury repair programs. Importantly, clarifying the role of BVES could potentially create new avenues of therapy. ..
  60. Rehabilitative Training Effects on Corticofugal Plasticity after Cortical Damage
    STEPHANIE CHRISTINE JEFFERSON; Fiscal Year: 2013
    ..This work is pursued to obtain a basal understanding of the anatomical and behavioral substrates that may be targeted in order to facilitate behavioral recovery after brain damage. ..
  61. Evaluation of STAT2 in a Model of Sporadic Colorectal Cancer
    Ana M Gamero; Fiscal Year: 2012
    ..Significance: These results will provide insights into whether STAT2 is oncogenic and may serve as a biomarker and/or molecular target for the chemoprevention of colorectal cancer. ..
  62. Development of Xenopus as a Model to Study Congenital Heart Disease
    Ann F Ramsdell; Fiscal Year: 2011
    ..echocardiography, optical activation mapping) and additional embryological techniques (caged fluorescent dextrans, tissue grafting) for use in Xenopus...
  63. VON WILLEBRAND FACTOR, FIBRINOLYSIS, & THE ENDOTHELIUM
    Karen Hamilton; Fiscal Year: 1991
    ....
  64. The impact of Helicobacter pylori infection on inflammatory bowel disease suscept
    John Kao; Fiscal Year: 2009
    ..pylori eradication on the host susceptibility to IBD. The completion of this project will also offer a potential mechanism through which beneficial bacteria (e.g., probiotics) may help to prevent IBD flares. ..
  65. Osteocyte reaction to decreased bone fluid flow
    Shijing Qiu; Fiscal Year: 2003
    ..The spatial relationship between osteoclastic resorption and osteocyte degeneration will be determined in the sections with toluidine blue and TUNEL stain. ..
  66. Novel Intervention for Colitis
    MICHAEL VITEK; Fiscal Year: 2007
    ..So we propose to directly measure whether COG112 will exacerbate or ameliorate colitis in mouse models. [unreadable] [unreadable] [unreadable]..
  67. Migration of polyomavirus JC across the blood-brain-barrier
    Vivek Nerurkar; Fiscal Year: 2009
    ....
  68. CELLULAR REGULATION OF KIDNEY EPITHELIAL CELL POLARITY
    Dennis Brown; Fiscal Year: 2006
    ..abstract_text> ..
  69. INTRAVENOUS FLUID THERAPY AND HEAD INJURY
    Steven Shackford; Fiscal Year: 1990
    ..Such information may lead to a reduction in the morbidity and mortality of head injury...
  70. BLOOD TISSUE IRON DEPLETION BY EXTRACORPOREAL CHELATOR
    CLARA AMBRUS; Fiscal Year: 1991
    ..She will prepare a series of carboxymethyl-dextrans with increase content of acid gropus for the binding of large amounts of the desferrioxamine for iron chelators...
  71. LCDIO FOR LYMPH NODE MR IMAGING
    Ralph Weissleder; Fiscal Year: 2001
    ..abstract_text> ..
  72. CONTROL OF THE CIRCULATION DURING THERMAL STRESS
    DUANE PROPPE; Fiscal Year: 1991
    ..These renal flow studies will enhance understanding of control of a vascular bed that may be involved in producing some forms of hypertension...
  73. Molecular Pathogenesis of Vibrio vulnificus
    PAUL GULIG; Fiscal Year: 2007
    ..These studies will elucidate mechanisms of fulminating, invasive disease caused by V. vulnificus as related to rapid replication, evasion of defenses, and damage to host tissues. ..
  74. CENTER FOR THE STUDY OF EMOTION AND ATTENTION
    Peter Lang; Fiscal Year: 2009
    ..Finally, we will carry out brain imaging of odor-mediated fear retention, extinction, and conditioned inhibition in anesthetized rats usingfMRI in an 11 T magnet measured with blood pressure ..